| Title of Invention | COMPOSITIONS AND METHODS FOR THE DELIVERY OF OXYGEN |
|---|---|
| Abstract | H-NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas O2 delivery. The engineered H-NOX proteins comprise mutations that impart altered O2 or NO ligand-binding relative to the corresponding wild-type H-NOX domain, and are operative as physiologically compatible mammalian blood O2 gas carriers. The invention also provides pharmaceutical compositions, kits, and methods that use wild-type or mutant H-NOX proteins for the treatment of any condition for which delivery of O2 is beneficial. |
| Full Text | COMPOSITIONS AND METHODS FOR THE DELIVERY OF OXYGEN |
|---|
2497-MUMNP-2008-ABSTRACT(7-3-2013).pdf
2497-MUMNP-2008-ASSIGNMENT(20-4-2009).pdf
2497-MUMNP-2008-CLAIMS(AMENDED)-(3-2-2014).pdf
2497-MUMNP-2008-CLAIMS(AMENDED)-(7-3-2013).pdf
2497-MUMNP-2008-CORRESPONDENCE (3-2-2014).pdf
2497-MUMNP-2008-CORRESPONDENCE(1-10-2012).pdf
2497-MUMNP-2008-CORRESPONDENCE(10-1-2012).pdf
2497-MUMNP-2008-CORRESPONDENCE(13-5-2009).pdf
2497-MUMNP-2008-CORRESPONDENCE(17-12-2008).pdf
2497-MUMNP-2008-CORRESPONDENCE(19-05-2010).pdf
2497-MUMNP-2008-CORRESPONDENCE(20-4-2009).pdf
2497-MUMNP-2008-CORRESPONDENCE(23-4-2009).pdf
2497-MUMNP-2008-CORRESPONDENCE(3-2-2014).pdf
2497-MUMNP-2008-CORRESPONDENCE(4-2-2013).pdf
2497-MUMNP-2008-CORRESPONDENCE(5-8-2013).pdf
2497-MUMNP-2008-CORRESPONDENCE(7-3-2013).pdf
2497-MUMNP-2008-FORM 1(3-2-2014).pdf
2497-MUMNP-2008-FORM 1(7-3-2013).pdf
2497-MUMNP-2008-FORM 13(7-3-2013).pdf
2497-MUMNP-2008-FORM 18(19-05-2010).pdf
2497-MUMNP-2008-FORM 2(TITLE PAGE)-(7-3-2013).pdf
2497-MUMNP-2008-FORM 3(1-10-2012).pdf
2497-MUMNP-2008-FORM 3(13-5-2009).pdf
2497-MUMNP-2008-FORM 3(3-2-2014).pdf
2497-MUMNP-2008-FORM 3(4-2-2013).pdf
2497-MUMNP-2008-MARKED COPY-(3-2-2014).pdf
2497-MUMNP-2008-OTHER DOCUMENT(3-2-2014).pdf
2497-MUMNP-2008-PCT-IB-301(17-12-2008).pdf
2497-MUMNP-2008-PCT-IB-326(23-4-2009).pdf
2497-MUMNP-2008-PCT-ISA-237(17-12-2008).pdf
2497-MUMNP-2008-PCT-ISA-237(23-4-2009).pdf
2497-MUMNP-2008-PCT-RO-101(17-12-2008).pdf
2497-MUMNP-2008-PETITION UNDER RULE-137(3-2-2014).pdf
2497-MUMNP-2008-POWER OF ATTORNEY(19-05-2010).pdf
2497-MUMNP-2008-POWER OF ATTORNEY(3-2-2014).pdf
2497-MUMNP-2008-REPLY TO EXAMINATION REPORT(7-3-2013).pdf
2497-MUMNP-2008-REPLY TO HEARING(3-2-2014).pdf
2497-MUMNP-2008-SECTION 8(2)-(4-2-2013).pdf
| Patent Number | 260925 | ||||||||||||||||||
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| Indian Patent Application Number | 2497/MUMNP/2008 | ||||||||||||||||||
| PG Journal Number | 22/2014 | ||||||||||||||||||
| Publication Date | 30-May-2014 | ||||||||||||||||||
| Grant Date | 28-May-2014 | ||||||||||||||||||
| Date of Filing | 20-Nov-2008 | ||||||||||||||||||
| Name of Patentee | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | ||||||||||||||||||
| Applicant Address | 1111 Franklin Street 12th Floor Oakland California 94607 United States of America | ||||||||||||||||||
Inventors:
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| PCT International Classification Number | C07K 14/00 | ||||||||||||||||||
| PCT International Application Number | PCT/US2007/012184 | ||||||||||||||||||
| PCT International Filing date | 2007-05-21 | ||||||||||||||||||
PCT Conventions:
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