Title of Invention

INTRAVENOUS CARDIAC PACING SYSTEM WITH WIRELESS POWER SUPPLY

Abstract A cardiac pacemaker (10) includes a power transmitter (14) which periodically transmits a pulse of a radio frequency signal (16) to a vascular electrode-stent (20) that is implantable in a vein or artery of an animal. The vascular electrode-stent (20) employs energy from the radio frequency signal to charge a storage device (40) which serves as an electrical power supply. The vascular electrode-stent (20) also detects a cardiac signal emitted from the sinus node of the heart and responds thereto by applying a pulse of voltage from the storage device to a pair of electrodes (36, 44) implantable in the vascular system of the animal. Application of the voltage pulse to the electrodes is intended to stimulate contraction of the heart.
Full Text

Background of the Invention
1. Field of the Invention
[0001] The present invention relates to implantable medical devices which deliver
energy to heart tissue to stimulate cardiac contractions, and more particularly to such
cardiac pacing devices that are implantable in a vein or artery.
2. Description of the Related Art
[0002] A remedy for people with slowed or disrupted natural heart activity is to
implant a cardiac pacing device which is a small electronic apparatus that stimulates
the heart to beat at regular rates.
[0003] Typically the pacing device is implanted in the patient's chest and has
sensor electrodes that detect electrical impulses associated with in the heart contractions.
These sensed impulses are analyzed to determine when irregular cardiac activity occurs,
in which event a pulse generator is triggered to produce electrical pulses. Wires carry
these pulses to patch-type stimulation electrodes placed adjacent specific cardiac
muscles, which when electrically stimulated contract the heart chambers. It is important

that the stimulation electrodes be properly located to produce contraction of the heart
chambers.
[001] Modern cardiac pacing devices vary the stimulation to adapt the heart rate to the
patient's level of activity, thereby mimicking the heart's natural activity. The pulse
generator modifies that rate by tracking the activity of the sinus node of the heart or by
responding to other sensor signals that indicate body motion or respiration rate.
[002] U.S. Patent No. 6,445,953 describes a cardiac pacemaker that has a pacing
device, which can be located outside the patient, to detect abnormal electrical cardiac
activity. In that event, the pacing device emits a radio frequency signal, that is
received by a circuit mounted on a stent implanted in a vein or artery of the patient's
heart. Specifically, the radio frequency signal induces a voltage pulse in an antenna on
the stent and that pulse is applied across a pair of electrodes on the stent, thereby
stimulating adjacent muscles and contracting the heart. Although this cardiac pacing
apparatus offered several advantages over other types of pacemakers, it required
placement of sensing electrodes on the patient's chest in order for the external pacing
device to detect when the heart requires stimulation.
Summary of the Invention
[003] A cardiac pacing apparatus is provided to artificially stimulate contractions of a
heart in a human being. That apparatus includes a power transmitter which periodically
transmits a pulse of a radio frequency signal to a vascular electrode-stent that is
implanted preferably in a vein or artery of the human being.

[004] The vascular electrode-stent comprises a pickup device, such as a coil of wire
for example, for receiving the radio frequency signal and a cardiac signal emitted from
the sinus node of the heart. A pacing signal circuit is connected to the pickup device
and a pair of electrodes that are in contact with tissue of the human being. The pacing
signal circuit has an electrical storage device that is charged by electrical energy from
the radio frequency signal. In response to detecting the cardiac signal, the pacing
signal circuit applies a stimulation voltage pulse across the pair of electrodes to cause a
contraction of the heart.
[005] In a preferred embodiment of the vascular electrode-stent, the pacing signal
circuit includes a discriminator and a pulse circuit. The discriminator is connected to
the pickup device and controls charging of the electrical storage device in response to
detecting a pulse of the radio frequency signal. When the discriminator detects the
cardiac signal, a trigger signal is produced, which causes the pulse circuit to apply the
stimulation voltage pulse across the pair of electrodes.
Brief Description of the Accompanying Drawings
[006] FIGURE 1 is a representation of a cardiac pacing apparatus attached to a
medical patient;
[007] FIGURE 2 is a circuit diagram of a power transmitter for the cardiac pacing
apparatus;
[008] FIGURE 3 is an isometric cut-away view of cardiac blood vessels in which a
vascular electrode-stent and a second electrode have been implanted;

(0012] FIGURE 4 is a block diagram of an electrical circuit on the vascular
elcctrode-stent shown in Figure 2; and
[0013] FIGURES 5 A, B, and C are waveform diagrams of three electrical signals
in the cardiac pacing apparatus.
Detailed Description of the Invention
[0014] With initial reference to Figure I, a pacing apparatus 10 for electrically
stimulating a heart 12 to contract comprises a power transmitter 14 and a vascular
electrode-stent 20. The power transmitter 14 preferably is worn outside the patient's
body adjacent the chest and emits a radio frequency signal 16 which is received by the
vascular electrode-stent 20. Alternatively, the power transmitter 14 may be implanted in
the patient. As will be described in greater detail, receipt of radio frequency signal 16
provides electrical power for circuitry on the electrode-stent. The vascular electrode-
stent 20 is placed in an artery or vein 18 which carries blood through the heart in close
proximity to the sinus node. For example the vascular electrode-stent 20 may be
positioned in the artery.
[0015] Referring to Figure 2, the power transmitter 14 comprises a radio frequency
(RF) transmitter 22 connected to a timing circuit 24 and to an antenna 26. Both the RF
transmitter 22 and the timing circuit 24 are powered by a battery 28. The timing circuit
24 controls the RF transmitter 22 to emit periodic pulses of the radio frequency signal
16. For example, the pulses have relatively slow rising and falling edges, as shown in
Figure 4A, so that the signal level gradually increases and decreases.

[0016] As illustrated in Figure 3, the electrode-stent 20 includes a body 30 similar
to well-known expandable vascular stents that are employed to enlarge a restricted vein
or artery. Such vascular stents have a generally tubular shape that initially is collapsed
to a relatively small diameter enabling them to pass freely through blood vessels of a
patient. The procedure for implanting the electrode-stent 20 is similar to that used for
conventional vascular stents. For example, a balloon at the end of a standard catheter is
inserted into the vascular electrode-stent 20 in a collapsed configuration. That
assembly is inserted through an incision in a vein or artery near the skin of a patient and
pushed through the vascular system to the appropriate location proximate to the sinus
node of the heart 12. The balloon of the catheter then is inflated to expand the vascular
electrode-stent 20, thereby slightly enlarging the blood vessel 18 which embeds the
electrode-stent in the wall of the vein or artery. The balloon is deflated, the catheter is
removed from the patient, and the incision is closed. Alternatively, a self-expanding
stent may be utilized as the body 30. The slight enlargement of the blood vessel 18 and
the tubular design of the stent's body 30 allows blood to flow relatively unimpeded
through the vascular electrode-stent 20.
[0017] With reference to Figures 3 and 4, the vascular electrode-stent 20 has a
pacing signal circuit 32 and a pickup device 34 in the form of a wire coil wound
circumferentially around the body 30. A first electrode 36 in the form of a ring
encircles the body. The pacing signal circuit 32 includes a pulse discriminator 38
connected to the pickup device 34. As will be described, the pulse discriminator 38
distinguishes between electrical pulses induced in the pickup device by electrical
events at the sinus node of the heart and by the RF signal 16 from the power

transmitter 14. That distinguishing is based on the shape of the respective signal
waveform and the pulses of those waveforms as illustrated in Figure 4A for the RF
signal 16 and in Figure 4B for the cardiac signal from the sinus node. The RF signal
has relatively long duration pulses with gradually rising and falling edges. In
contrast, the electrical pulses of the cardiac signal are very short duration and rise and
fall quickly. The pulse discriminator 38 also is able to detect when both types of
pulses coincide in time.
[0018) Whenever an RF signal pulse is detected, the pulse discriminator 38 uses
the energy of that signal to charge a storage capacitor 40 which supplies electrical
power to the circuitry on the vascular electrode-stent 20. Other types of electrical
storage devices may be employed. The radio frequency signal supplies power to the
vascular electrode-stent, and unlike prior wireless pacemakers does not trigger cardiac
stimulation.
[0019] The sinus node of the heart 12 emits an electrical cardiac signal which
causes contraction of the heart chambers. The cardiac signal travels from cell to cell
in paths through the heart to muscles which contract the atria. This signal also
propagates along another path until reaching the atrioventricular (AV) node, which
is a cluster of cells situated in the center of the heart between the atria and ventricles.
The atrioventricular node serves as a gate that slows the electrical current before the
cardiac signal is permitted to pass to the ventricles. This delay ensures that the atria
have a chance to fully contract before the ventricles are stimulated.

[0020] Due to the placement of the vascular electrode-stent 20 in proximity to the
sinus node, emission of the cardiac signal also induces an electric current pulse in the
pickup device, or coil, 34 of the vascular electrode-stent 20, as depicted in Figure 4B.
The pulse discriminator 38 recognizes the rapid rise time of this pulse as being
produced by the cardiac signal, as compared to a RF signal pulse shown in Figure 4A.
When a cardiac signal pulse is detected, the pulse discriminator 38 issues a trigger
signal to a pulse circuit 42. The pulse circuit 42 is similar to circuits used in previous
cardiac pacing devices which generate voltage pulses for stimulating a contraction of
the heart, as shown in Figure 5C. Specifically, upon being triggered the pulse circuit 42
uses the charge on the capacitor 40 to produce a voltage pulse that is applied between
the first electrode 36, that extends around the stent body, and a second electrode 44,
which is remote from the vascular electrode-stent 20.
(0021) As shown in Figure 3, the second electrode 44 is secured to the wall of a
blood vessel 46 in another section of the heart and is connected to the pulse circuit 42
by a thin insulated wire 48 extending through the blood vessels. The relatively small
size of the second electrode 44 allows it to be placed into a significantly smaller blood
vessel 46 than the vascular electrode-stent 20. As a result, the second electrode 44 can
be placed is a greater variety of locations in the cardiac vascular system and in close
proximity to the muscles that contract the desired portion of the heart 12.
[0022] Depending upon whether the second electrode 44 is placed to stimulate
contraction of an atrium or a ventricle, the pulse circuit 42 delays a predefined amount of
time after receiving the trigger signal from the pulse discriminator 38 before applying
the voltage pulse to the first and second electrodes. Therefore, timing of muscle

stimulation corresponds to that which occurs with respect to naturally induced
contraction of the atrium or ventricle. The duration of that delay is programmed into the
pulse circuit 42 by the surgeon upon implantation and is a function of the location of the
second electrode.
[0023] In another version of the vascular electrode-stent 20, one or more additional
electrodes, such as a third electrode 50, can be implanted in other cardiac blood vessels
52 to stimulate further sections of the heart In this case, individual voltage pulses can be applied between the first electrode 36 and each of the additional electrodes 44 and
50 to separately stimulate contraction of those other sections of the heart. A stimulation pulse also may be applied between the second and third electrodes 44 and 50, without
using the first electrode 36.
[0024] The foregoing description was primarily directed to preferred embodiments
of the invention. Even though some attention was given to various alternatives within
the scope of the invention, it is anticipated that one skilled in the art will likely realize
additional alternatives that are now apparent from disclosure of embodiments of the
invention. Accordingly, the scope of the invention should be determined from the
following claims and not limited by the above disclosure.

We claim:
1. A cardiac pacing apparatus, for artificially stimulating contractions in a
heart of a human being, comprising:
a power transmitter which periodically transmits a pulse of a radio frequency
signal;
a first electrode and a second electrode for implantation in the human being;
and
a vascular electrode-stent for implantation in a blood vessel of the human
being and comprising a pickup device for receiving the radio frequency signal and a
cardiac signal emitted from a sinus node of the heart, and a pacing signal circuit
connected to the pickup device and having an electrical storage device, wherein the
pacing signal circuit comprises:
(a) a discriminator connected to the pickup device, and charging the electrical
storage device with electrical energy from the radio frequency signal in
response to detecting a pulse of the radio frequency signal, and producing
a trigger signal in response to detecting the cardiac signal; and
(b) a pulse circuit connected to the discriminator and the electrical storage
device, and in response to the trigger signal, applying a stimulation
voltage pulse across the first electrode and the second electrode to cause
a contraction of the heart.
2. The apparatus as claimed in claim 1 wherein the first electrode is mounted
on the vascular electrode-stent.

3. The apparatus as claimed in claim 1 wherein the electrical storage device is a
capacitor.
4. The apparatus as claimed in claim 1 wherein the pickup device comprises a
coil.

5. The apparatus as claimed in claim 1 wherein the discriminator distinguishes
between the radio frequency signal from the power transmitter and the cardiac signal
emitted from the sinus node based on differences in their signal waveforms.
6. The apparatus as claimed in claim 5 wherein each pulse of the radio
frequency signal from the power transmitter has a leading edge which is longer in
duration than a leading edge of the cardiac signal emitted from the sinus node.
7. The apparatus as claimed in claim 1 wherein pulses of the radio frequency
signal from the power transmitter and pulses of the cardiac signal emitted from the
sinus node are asynchronous.
8. The apparatus as claimed in claim 1 further comprising a third electrode for
implantation in the human being and connected to the vascular electrode-stent, wherein
the pacing signal circuit applies a voltage pulse to the third electrode.
9. The apparatus as claimed in claim 1 wherein the second electrode is
adapted for implantation in a blood vessel of the human being.

10. The apparatus as claimed in claim 1 wherein the vascular electrode-stent
comprises a body that is expandable within the blood vessel from a first cross-sectional
size to a second cross-sectional size.
11. The apparatus as claimed in claim 10 wherein the first electrode is a
conductive ring that encircles the body of the vascular electrode-stent.



ABSTRACT


INTRAVENOUS CARDIAC PACING SYSTEM
WITH WIRELESS POWER SUPPLY
A cardiac pacemaker (10) includes a power transmitter (14) which periodically
transmits a pulse of a radio frequency signal (16) to a vascular electrode-stent (20) that
is implantable in a vein or artery of an animal. The vascular electrode-stent (20)
employs energy from the radio frequency signal to charge a storage device (40) which
serves as an electrical power supply. The vascular electrode-stent (20) also detects a
cardiac signal emitted from the sinus node of the heart and responds thereto by applying
a pulse of voltage from the storage device to a pair of electrodes (36, 44) implantable in
the vascular system of the animal. Application of the voltage pulse to the electrodes is
intended to stimulate contraction of the heart.

Documents:

01225-kolnp-2006 abstract.pdf

01225-kolnp-2006 claims.pdf

01225-kolnp-2006 correspondence others.pdf

01225-kolnp-2006 description(complete).pdf

01225-kolnp-2006 drawings.pdf

01225-kolnp-2006 form-1.pdf

01225-kolnp-2006 form-3.pdf

01225-kolnp-2006 form-5.pdf

01225-kolnp-2006 international publication.pdf

01225-kolnp-2006 international search authority report.pdf

01225-kolnp-2006 pct form.pdf

01225-kolnp-2006-assignment.pdf

01225-kolnp-2006-correspondence others-1.1.pdf

01225-kolnp-2006-correspondence-1.2.pdf

01225-kolnp-2006-form-18.pdf

01225-kolnp-2006-priority document.pdf

1225-KOLNP-2006-(04-10-2012)-AMANDED PAGES OF SPECIFICATION.pdf

1225-KOLNP-2006-(04-10-2012)-CORRESPONDENCE.pdf

1225-KOLNP-2006-(27-09-2012)-CORRESPONDENCE.pdf

1225-KOLNP-2006-ABSTRACT.pdf

1225-KOLNP-2006-AMENDED CLAIMS.pdf

1225-kolnp-2006-ASSIGNMENT.pdf

1225-kolnp-2006-CANCELLED PAGES-1.1.pdf

1225-KOLNP-2006-CANCELLED PAGES.pdf

1225-kolnp-2006-CORRESPONDENCE.pdf

1225-kolnp-2006-DECISION.pdf

1225-KOLNP-2006-DESCRIPTION (COMPLETE).pdf

1225-KOLNP-2006-DRAWINGS.pdf

1225-kolnp-2006-EXAMINATION REPORT.pdf

1225-KOLNP-2006-FORM 1.pdf

1225-kolnp-2006-FORM 13-1.1.pdf

1225-KOLNP-2006-FORM 13.pdf

1225-kolnp-2006-FORM 18.pdf

1225-KOLNP-2006-FORM 2.pdf

1225-KOLNP-2006-FORM 3 1.1.pdf

1225-KOLNP-2006-FORM 3.pdf

1225-kolnp-2006-GPA.pdf

1225-kolnp-2006-GRANTED-ABSTRACT.pdf

1225-kolnp-2006-GRANTED-CLAIMS.pdf

1225-kolnp-2006-GRANTED-DESCRIPTION (COMPLETE).pdf

1225-kolnp-2006-GRANTED-DRAWINGS.pdf

1225-kolnp-2006-GRANTED-FORM 1.pdf

1225-kolnp-2006-GRANTED-FORM 2.pdf

1225-kolnp-2006-GRANTED-FORM 3.pdf

1225-kolnp-2006-GRANTED-FORM 5.pdf

1225-kolnp-2006-GRANTED-SPECIFICATION-COMPLETE.pdf

1225-kolnp-2006-INTERNATIONAL PUBLICATION.pdf

1225-kolnp-2006-INTERNATIONAL SEARCH REPORT & OTHERS.pdf

1225-kolnp-2006-OTHERS-1.1.pdf

1225-KOLNP-2006-OTHERS.pdf

1225-kolnp-2006-PETITION UNDER RULE 137-1.1.pdf

1225-KOLNP-2006-PETITION UNDER RULE 137.pdf

1225-KOLNP-2006-REPLY TO EXAMINATION REPORT 1.1.pdf

1225-kolnp-2006-REPLY TO EXAMINATION REPORT-1.1.pdf

1225-KOLNP-2006-REPLY TO EXAMINATION REPORT.pdf

abstract-01225-kolnp-2006.jpg


Patent Number 262603
Indian Patent Application Number 1225/KOLNP/2006
PG Journal Number 36/2014
Publication Date 05-Sep-2014
Grant Date 29-Aug-2014
Date of Filing 11-May-2006
Name of Patentee KENERGY, INC.
Applicant Address 2130 WEST COLUMBIA DRIVE, MEQUON, WI 53092
Inventors:
# Inventor's Name Inventor's Address
1 DENKER STEPHEN 2130 WEST COLUMBIA DRIVE, MEQUON, WI 53092
2 BEUTLER ARTHUR J. 5890 FLEMING COURT, GREENDALE, WI 53129
PCT International Classification Number A61N 1/18
PCT International Application Number PCT/US2004/036059
PCT International Filing date 2004-10-28
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 10/700,148 2003-11-03 U.S.A.