Title of Invention	NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
Abstract	The present invention provides compounds for treating or preventing an HIV infection, or treating AIDs or ARC comprising administering a compound according to formula (I) where Ar5 R1, -R5,R11C and X1 are as defined herein.

Full Text

Non-Nucleoside Reverse Transcriptase Inhibitors The invention relates to the field of antiviral therapy and, in particular, to non-nucleoside compounds that inhibit HIV reverse transcriptase and are useful for treating Human Immunodeficiency Virus (HIV) mediated diseases. The invention provides novel N-phenyl phenylacetamide compounds according to formula I, for treatment or prophylaxis of HIV mediated diseases, AIDS or ARC, employing said compounds in monotherapy or in combination therapy. The human immunodeficiency virus HIV is the causative agent of acquired immunodeficiency syndrome (AIDS), a disease characterized by the destruction of the immune system, particularly of the CD4+ T-cell, with attendant susceptibility to opportunistic infections. HIV infection is also associated with a precursor AIDs-related complex (ARC), a syndrome characterized by symptoms such as persistent generalized lymphadenopathy, fever and weight loss. In common with other retroviruses, the HIV genome encodes protein precursors known as gag and gag-pol which are processed by the viral protease to afford the protease, reverse transcriptase (RT), endonuclease/integrase and mature structural proteins of the virus core. Interruption of this processing prevents the production of normally infectious virus. Considerable efforts have been directed towards the control of HIV by inhibition of vixally encoded enzymes. Currently available chemotherapy targets two crucial viral enzymes: HIV protease and HIV reverse transcriptase. (J. S. G. Montaner et at Antiretroviral therapy: 'the state of the art\ Biomed & Pharmacother. 1999 53:63- 72; R. W. Shafer and D. A. Vuitton, Highly active retroviral therapy (HAART) for the treatment of infection with human immunodeficiency virus typey Biomed. & Pharmacother. 1999 53 :73-86; E. De Clercq, New Developments in Anti-HIV Chemotherap. Curr. Med. Chem. 2001 8:1543-1572). Two general classes of RTI inhibitors have been identified: nucleoside reverse transcriptase inhibitors (NRTI) and non-nucleoside reverse transcriptase inhibitors. NRTIs typically are 2,,3,-dideoxynucleoside (ddN) analogs which must be phosphorylated prior to interacting with viral RT. The corresponding triphosphates function as competitive inhibitors or alternative substrates for viral RT. After incorporation into nucleic acids the nucleoside analogs terminate the chain elongation process. HIV reverse transcriptase has DNA editing capabilities which enable resistant strains to overcome the blockade by cleaving the nucleoside analog and continuing the elongation. Currently clinically used NRTls include zidovudine (AZT), didanosine (ddl), zalcitabine (ddC), stavudine (d4T), lamivudine (3TC) and tenofovir (PMPA). NNRTIs were first discovered in 1989. NNRTI are allosteric inhibitors which bind reversibly at a nonsubstrate-binding site on the HIV reverse transcriptase thereby altering the shape of the active site or blocking polymerase activity (R. W. Buckheit, Jr., Non-nucleoside reverse transcriptase inhibitors: perspectives for novel therapeutic compounds and strategies for treatment of HIV infection. Expert Opin. Investig Drugs 200110(8): 1423-1442; E. De Clercq The role of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV infection, Antiviral Res. 1998 38:153-179; E. De Clercq New Developments in Anti-HIV Chemotherapy, Current Medicinal Chem. 2001 8(13):1543-1572; G. Moyle, The Emerging Roles ofNon-Nucleoside Reverse Transcriptase Inhibitors in Antiviral Therapy, Drugs 2001 61 (l):19-26). Although over thirty structural classes of NNRTIs have been identified in the laboratory, only three compounds have been approved for HTV therapy: efavirenz, nevirapine and delavirdine. Initially viewed as a promising class of compounds, in vitro and in vivo studies quickly revealed the NNRTIs presented a low barrier to the emergence of drug resistant HIV strains and class-specific toxicity. Drug resistance frequently develops with only a single point mutation in the RT. While combination therapy with NRTIs, Pis and NNRTIs has, in many cases, dramatically lowered viral loads and slowed disease progression, significant therapeutic problems remain. (R. M. Gulick, Eur. Soc. Clin. Microbiol, and Inf. Dis. 2003 9(3):186-193) The cocktails are not effective in all patients, potentially severe adverse reactions often occur and the rapidly reproducing HIV virus has proven adroit at creating mutant drug-resistant variants of wild type protease and reverse transcriptase. There remains a need for safer drugs with activity against wild type and commonly occurring resistant strains of HTV. Certain N-phenyl phenylacetamide compounds have been found to have a variety of pharmacological properties. US 20030187068 (H. Miyachi etal) discloses N-phenyl phenylacetamide compounds which are peroxisome proliferators-activated receptor (PPARa) ligands. US 20030220241 (D. Defoe-Jones et al) disclose N-phenyl phenylacetamide compounds use to prepare protein conjugates with a prenyl protein transferase which are cleaved by prostate-specific antigen and are useful for treating cancer. W09917777 (J. S. Desolms et al) teach prenyl protein transferase compounds which include N-phenyl phenylacetamides. N-(substituted)phenyI 3-phenoxy-phenyiacetamide compounds have been disclosed in WO01/21596 (A. A. Mortlock et al)a$ inhibitors of aurora 2 kinase which are potentially useful in the treatment of proliferative diseases. N-phenyl 3-(substituted)phenoxy-phenylacetamide compounds have be disclosed in WO2000059930 as inhibitors of prenyl protein transferase. N-(substituted)phenyl3-phenoxy-phenylacetamide compounds have been disclosed in US2003011435 (K. Tani etal.) as EP4 receptor antagonists which are potentially useful in the suppression of TNF-a production and induction of IL-10 production. Benzanilide compounds have been disclosed in W09965874 (Y. Ohtake et al.) as vasopressin antagonists. N-phenyl phenylacetamide compounds 1 wherein R can be substituted aryl, X can be O, n can be 0, R4 and R5 can be hydrogen have been disclosed in W09315043 (T. Oe et al) as acetyl CoA cholesterol O-acyltransferase inhibitors useful for reducing blood lipid levels and for treating arteriosclerosis. N-Phenyl phenylacetamides have also been used as synthetic intermediates for the preparation of pharmacologically active compounds. N-(2-carboalkoxy-5-chloro-phenyl) phenylacetamides (A. Krexmeyer etal, J. Med, Chem. 1999 42:4394-4404; J. J. Kulagowski et at, I Med. Chem. 1994 37:1402-1405 K. Ackermann etaU WO 97/26244), N-(2-cyano-5-chloro-phenyl) phenylacetamides (M. Rowley etal> J. Med. Chem. 1997 40:4053-4068; R. W. Carling et aU I Med. Chem., 1997 40:754-765 and N-(2-nitrophenyl) phenylacetamides ( J. F. W. Keana et al, WO 96/22990) have been disclosed and utilized as intermediates for the synthesis of ligands for the glycine site on the N-methyl-D-aspartate (NMDA) receptor. NMDA ligands have been investigated for treating CNS disorders thought to be related neuronal death caused by over-stimulation of the post synaptic receptor sensitive to N-methyl-D-aspartic acid. Such disorders include Alzheimer's disease, epilepsy and cerebral ischemia. These compounds and indications are unrelated to the present invention. 2-Benzoyl phenyl-N-[phenyl] -acetamide compounds 2a and 2b have been shown to inhibit HTV-1 reverse transcriptase (P. G. Wyatt et al, J. Med. Chem. 1995 38(10):1657-1665). Further screening identified related compounds, eg. 2-benzoyl phenyloxy-N-[phenyl]-acetamide, 3a, and a sulfonamide derivative 3b which also inhibited reverse transcriptase (J. H. Chan et al, J. Med Chem. 2004 47(5):1175-1182; C. L. Webster et at, WO01/17982). wherein X1 is selected from the group consisting of -0-, -S -, -CH2-, -C(O)-; R1 and IT are each independently selected from the group consisting of hydrogen, Q.$ alkyl, Cushaloalkyl, C3-8 cycloalkyl, Q^ alkoxy, Q-g alkylthio, Q_6 alkylsulfinyl, C^ sulfonyl, Ci-6 haloalkoxy, Q.g haloalkylthio, halogen, amino, alkylamino, dialkylamino, acylamino, nitro and cyano; or together R and R are -0-CH=CH-or -O-CH2CH2-; R3 and R4 are independently selected from the group consisting of hydrogen, C\^ alkyl, C1.6 haloallcyl, Q.6 alkoxy, Q^ haloalkoxy Q^ alkylthio, Q-6 haloalkylthio, halogen, amino, nitro and cyano; R5 is selected from the group consisting of Q_6 alkyl, Q-6 haloalkyl, Q.g cycloalkyl, aryl or heteroaryl selected from the group consisting of pyridinyl, N-hydroxypyridine, pyrimidinyl, indole, pyrazinyl and pyrrolyl; wherein, said aryl and said heteroaryl are optionally substituted with one to three substituents independently selected from the group consisting of C^ alkyl, Q_6 alkenyl, Q_6 alkynyl, Q.6 haloalkyl, C3-8 cycloalkyl, Q.fi alkoxy, Q_6 alkylthio, Q_6 alkylsulfinyl, Q.6 sulfonyl, Q.$ haloalkoxy, Q_6 haloalkyithio, hydroxy, halogen, amino, Q-6 alkylamino, Q-6 dialkylamino, acylamino, acyl, Q-6 alkoxycarbonyl, carbamoyl, Q-e N-alkylcarbamoyl, Q.6N,N-diaIkylcarbamoyl, alkynol, -C^CCH2OH, -C^CCH2N(CH3)2, nitro and cyano, said alkyl and said cycloalkyl are optionally substituted with one or two substituents independently selected from the group consisting of alkyl, hydroxy, alkoxy, thiol, alkylthio, halogen, amino, alkylamino, dialkylamino, amino alkyl, alkylaminoalkyl, and dialkylamino; AT is phenyl optionally substituted with 1 to 3 substituents independently selected in each incidence is from the group consisting of Q,6 alkyl, Q.8 cycloalkyl, Q-3 haloalkyl, Q-6 alkoxy, Q.6 haloalkoxy, halogen, cyano, Q-6 alkylthio, Q_6 alkylsulfinyl, Q.6 sulfonyl, amino Q_e alkylsulfonyl, Q-6 haloalkoxy, Q.6 haloalkylthio, Q-6 acyl, nitro, Q-6 heteroalkyl, Q_6 heteroalkoxy, hydroxyl, -X2(CH2)pS(0)nNR8R^-(CH2)pCOOR1\--X2(CH2)pNHC(0)NHR8R9, X2(CH2)pCONR8R9,-S02R13> -NR8aR9a, X2(CH2)pNRnS(0)2NR8R9, -X2(CH2)pNHCOOR10, -X6(CH2)pCOOR10, -X2(CH2)pCN, -OR15 and C(=0)CH2N[(CH2)2]2X4; or, heteroaryl ring selected from the group consisting of pyridinyl, pyrazolyl and triazolyl said heteroaryl ring optionally substituted with one to three substituents selected from the group consisting of Q-6 alkyl, Q.6 alkoxy, Q-6 alkylthio, halogen, Q.6 aminoacyl cyano and NR8 R9 ; R8 and R9 taken independently, one of R8 and R9 is hydrogen or Q_6 alkyl and the other of R8 and R9 is selected from the group consisting of hydrogen, -C(=0)RU, -C(=0)CHR12NH2, -(CH2)2N[(CH2)2]20> COC02Me, C3-a cycloalkyl said cycloalkyl optionally substituted with one or two hydroxyl substituents, pyranyl, Q-6 alkyl and aryl said alkyl and said aryl groups optionally substituted with one or two substituents independently selected from the group consisting of hydroxy, Q-6 alkoxy, thiol, Q-6 alkylthio, Q-e alkylsulfinyl, Q-6 sulfonyl, and halogen; or, (ii) R8 and R9 taken together are (CH2)2-X5-(CH2)2 or -(CH2)0- optionally substituted with one or two substituents selected from the group consisting of halogen, hydroxyl andNRUaRub; R8a and R9a taken independently are selected from the group consisting of hydrogen, Q-6 alkyl, C(=0)C02Rn and S02R10, or (ii) taken together are (CH2)rS02, (CH2)2S(0)p(CH2)2; R10 is Ci-6 alkyl; R11 is hydrogen or Ci-6 alkyl; RUa, Rnb and Rllc are independently R11; R12 is the side chain of a naturally occurring a-amino acid; 5 R13 is Q.6 alkyl; -(CH2)sC02RnJ -(CH2)2CN, -(CH2)2NH2, -(CH2)uOH; R14 is Ci.6 alkyl, -(CH2)sNHRUaRllb, (CH2)sORn, -CH2CH(OH)CH3, CH2N[(CH2)2]20, -(CH2)2C02Ru, optionally substituted phenyl or pyridinyl; R15 is Ci-6 alkyl optionally substituted with one to three hydroxyl groups; X is -O- or a bond; 10 X4 is -O- or -NMe-; X5 is-0->-S(0)n-orNRn; X6 is O- or -S(0)n-; n is an integer from 0 to 2; o is an integer from 4 to 6; 15 p is an integer from 0 to 6; r is an integer from 3 to 4 s is an integer from 1 to 2; u is an integer from 2 to 3; and, hydrates, solvates and salts thereof; 20 for the manufacture of a medicament for treating an HIV infection, or preventing an HTV infection, or treating AIDS or ARC. Further objects of the present invention are: (ii) Use of compounds of formula I according to (i) wherein XI is selected from the group consisting of -O-, -S -, -CHo-, -C(O)-; R1 and R" are each independently selected from the group consisting of hydrogen, Cue alkyl, Q.6 haloalkyl, C3_8 cycloalkyl, Ci_6 alkoxy, Ci-6 alkylthio, Ci-6 alkylsulfinyl, Cu6 sulfonyl, Q.6 haloalkoxy, Cue haloalkylthio, halogen, amino, alkylamino, dialkylamino, acylamino, nitro and cyano; or together R1 and R2 are -0-CH=CH-or -O-CH2CH2S R3 and R4 are independently selected from the group consisting of hydrogen, Cue alkyl, Q_6 haloalkyl, Cue alkoxy, Cue haloalkoxy, Ci.6 alkylthio, Cue haloalkylthio, halogen, amino, nitro and cyano; R5 is selected from the group consisting of Ci_6 alkyl, Cu6 haloalkyl, C3.8 cycloalkyl, aryl or heteroaryl selected from the group consisting of pyridinyl, N-hydroxypyridine, pyrimidinyl, indole, pyrazinyl and pyrrolyl; wherein, said aryl and said heteroaryl are optionally substituted with one to three substituents independently selected from the group consisting of Q^ alkyl, C2-6 alkenyl, C2.6 alkynyl, Cue haloalkyl, C3.8 cycloalkyl, Cue alkoxy, Cue alkylthio, Q-6 alkylsulfinyl, Cue sulfonyl, Q_6 haloalkoxy, Q.6 haloalkylthio, hydroxy, halogen, amino, Cue alkylamino, Cue dialkylamino, acylamino, acyl, Cue alkoxycarbonyl, carbamoyl, Cue N-alkylcarbamoyl, Ci-6N,N-dialkylcarbamoyl, nitro and cyano, said alkyl and said cycloalkyl are optionally substituted with one or two substituents independently selected from the group consisting of alkyl, hydroxy, alkoxy, thiol, alkylthio, halogen, amino, alkylamino, dialkylamino, amino alkyl, alkylaminoalkyl, and dialkylamino; AT is phenyl optionally substituted with 1 to 3 substituents independently selected in each incidence is from the group consisting of C\.6 alkyl, C3.8 cycloalkyl, C1-3 haloalkyl, Q-6 alkoxy, Q_6 haloalkoxy, halogen, cyano, Q^ alkylthio, Q,6 alkylsulfinyl, Cue sulfonyl, amino C\^ alkylsulfonyl, Cue haloalkoxy, Q_6 haloalkylthio, Cu6 acyl, nitro, Q-6 heteroalkyl, Q^ heteroalkoxy, hydroxyl, -X2(CH2)pS(0)nNR8R9;-(CH2)pCOORn,--X2(CH2)pNHC(0)NHR8R9) X2(CH2)pCONR8R9,-S02R13, -NR8aR9a, X2(CH2)pNRnS(0)2NR8R9, -X2(CH2)pNHCOOR10, -X6(CH2)pCOOR10, -X2(CH2)PCN, -OR15 and C(=0)CH2N[(CH2)2]2X4;or, heteroaryl ring selected from the group consisting of pyridinyl, pyrazolyl and triazolyl said heteroaryl ring optionally substituted with one to three substituents selected from the group consisting of C\-6 alkyl, Q^ alkoxy, C\-6 alkylthio, halogen, Cue aminoacyl and NR8bR9b; R8 and R9 taken independently, one of R8 and R9 is hydrogen or Q_6 alkyl and the other of R8 and R is selected from the group consisting of hydrogen, -C(=0)R14, -C(=0)CHR12NH2, -(CH2)2N[(CH2)2]20> COC02Me, C3.8 cycloalkyl said cycloalkyl optionally substituted with one or two hydroxyl substituents, pyranyl, Q-g alkyl and aryl said alkyl and said aryl groups optionally substituted with one or two substituents independently selected from the group consisting of hydroxy, ds alkoxy, thiol, Cue alkylthio, Q_6 alkylsulfinyl, Ci-6 sulfonyl, and halogen; or, (ii) R8 and R9 taken together are (CH2)2-X5-(CH2)2 or -(CH2)0- optionally substituted with one or two substituents selected from the group consisting of halogen, hydroxyl andNRllaRub; R8a and R9a taken independently are selected from the group consisting of hydrogen, Cue alkyl, C(=0)C02Rn and S02R10, or (ii) taken together are (CH2)rS02> (CH2)2S(0)p(CH2)2; R10 is Ci-6 alkyl; Ru is hydrogen or Q-6 alkyl; Rlla, Rnb and RUc are independently R11; R12 is the side chain of a naturally occurring a-amino acid; R13 is Ci.6 alkyl; -(CH2)sC02Rn, -(CH2)2CN, -(CH2)2NH2> -(CH2)uOH; R14 is d.6 alkyl, -(CH2)sNHRIlaRub) (CH2)sORn, -CH2CH(OH)CH3, CH2N[(CH2)2]20, -(CH2)2C02Ru, optionally substituted phenyl or pyridinyl; R15 is Q-6 alkyl optionally substituted with one to three hydroxyl groups; X2 is -O- or a bond; X4 is -O- or -NMe-; X5 is-0-,-S(0)n-orNRn; X6 is O- or -S(0)n-; n is an integer from 0 to 2; o is an integer from 4 to 6; p is an integer from 0 to 6; r is an integer from 3 to 4 s is an integer from 1 to 2; u is an integer from 2 to 3; and, hydrates, solvates and salts thereof; for the manufacture of a medicament for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. (iii) Use of compounds of formula I according to (i) or (ii), wherein X1 is selected from the group consisting of -O, -S -, -CH2-, -C(O)-; Rl and Rx are each independently selected from the group consisting of hydrogen, Q_6 alkyl, C1-6 alkoxy and halogen; or together R and R are -0-CH=CH- or -0-CH2CH2-; R3 and R4 are independently selected from the group consisting of hydrogen and halogen; R5 is aryl or heteroaryl selected from the group consisting of pyridinyl, N- hydroxypyridine, pyrimidinyl, indole, pyrazinyl and pyrrolyl; wherein, said aryl and said heteroaryl are unsubstituted or substituted with one to three substituents independently selected from the group consisting of Q_6 alkyl, Q_e haloalkyl, Q_6 haloalkoxy, Q-ahaloalkoxy, halogen, -OCCH2OH, -C^CCH2N(CH3)2 and cyano. Ar is phenyl optionally substituted with 1 to 3 substituents independently selected from the group consisting of Q.6 alkyl, Q.s cycloalkyl, Q.3 haloalkyl, Q-e alkoxy, halogen, cyano, Q^ alkylsulfinyl, Q.6 sulfonyl, amino Q_6 alkylsulfonyl, Q.6 haloalkoxy, Q_6 haloalkylthio, Q_e acyl, nitro, Q-6 heteroalkyl, Q.6 heteroalkoxy, hydroxy!, -X2(CH2)PS(0)nNR8R9; -(CH2)pCOORn, -X2(CH2)pNHC(0)NHR8R9, X2(CH2)pCONR8R9)-S02R13, -NR8aR9a, X2(CH2)pNRnS(0)2NR8R9, -X2(CH2)pNHCOOR10, -X6(CH2)pCOOR10, -X2(CH2)PCN, -OR15 and C(=0)CH2N[(CH2)2]2X4; or, heteroaryl ring selected from the group consisting of pyridinyl, pyrazolyl and triazolyl said heteroaryl ring optionally substituted with one to three substituents selected from the group consisting of Ci-e alkyl, Q.6 alkoxy, Q_6 alkylthio, halogen, Q-6 aminoacyl, cyano and NR8bR9b; R8 and R9 taken independently, one of R8 and R9 is hydrogen or Q_6 alkyl and the other of R8 and R9 is selected from the group consisting of hydrogen, -C(=0)R14, -C(=0)CHR12NH2, -(CH2)2N[(CH2)2]20> COC02Me, C3-8 cycloalkyl said cycloalkyl optionally substituted with one or two hydroxyl substituents, pyranyl, Q. 6 alkyl and aryl said alkyl and said aryl groups optionally substituted with one or two substituents independently selected from the group consisting of hydroxy, Q_6 alkoxy, thiol, Q_6 alkylthio, Ci.6 alkylsulfinyl, Q.6 sulfonyl, and halogen; or, (ii) R8 and R9 taken together are (CH2)2-X5-(CH2)2 or -(CH2)0- optionally substituted with one or two substituents selected from the group consisting of halogen, hydroxyl and NRUaRnb; R8a and R9a taken independently are selected from the group consisting of hydrogen, Q_e alkyl, C(=0)C02Rn and S02R10, or (ii) taken together are (CH2)rS02, (CH2)2S(0)p(CH2)2; R10 is Q.6 alkyl; R11 is hydrogen or Q_e alkyl; Rlla, Rllb and RUc are independently R11; R12 is the side chain of a naturally occurring a-amino acid; R13 is Q-6 alkyl; -(CH2)sC02Rn, -(CH2)2CN, -(CH2)2NH2, -(CH2)uOH; R14 is Q.6 alkyl, -(CH2)sNHR1IaRub, (CH2)sORu, -CH2CH(OH)CH3, CH2N[(CH2)2]20, -(CH2)2C02Rn, optionally substituted phenyl or pyridinyl; R15 is Q-6 alkyl optionally substituted with one to three hydroxyl groups; X2 is-O- or a bond; X4 is -O- or -NMe-; X5 is -O-, -S(0)n- or NR11; X6 is O- or -S(0)n-; n is an integer from 0 to 2; o is an integer from 4 to 6; p is an integer from 0 to 6; r is an integer from 3 to 4 -S02NCH3COCH2CH3, -SO2NCH3COCH2OCH3, -SO2NCH3COCH2CH2OCH3, -S02NHCOCH2OCH3> -S02NHCOCH2OH, -S02NHCOCH2CH2COOH, -S02CH2CH2NH2, -S02CH2COOH» -S02CH2CH2COOH, -S02CH3, -SC^CKUCEkCN, -S02CH2CH2CH2OH, -0(CH2)3S02NH2> -OCH2COOH, -OCH2COOCH3, -OCH2CN, -OCH2CHOHCH2OH, -OCH2CH2CHOHCH2OH, -SCH2COOCH3, -COOCH3>-COOH,-COCH2( ^N-), -COCH2( ^°), -CH2COOCH3, -CH2COOH, -CH2CH2COOCH3, CH2CH2CH2COOCH3, -N(CH3)2> -NHCOCOOCH2CH3> -NHS02CH3 and -NCH3S02CH3; or heteroaryl ring selected from the group consisting of pyridinyl, pyrazolyl and triazolyl said heteroaryl is unsubstituted or substituted with one or two substituents selected from the group consisting of methyl, methoxy -SCH3) and -NHCOOCH3; Rlic is hydrogen or methyl; and hydrates, solvates and salts thereof. (v) Use of compound of formula I according to (i), which compound is: 2-[4-Chloro-3-(3-chloro-5-cyrano-phenoxy)-2-fluoro-phenyI]-N-(2-chloro-4-sulfamoyl-phenyl)-acetamide; 2-[4-chloro-3-(3«chloro-5-cyano-phenoxyr)-2-fluoro-phenyl]-N-(2-chloro-4-propionylsulfamoyl-phenyl)-acetamide; sodium salt; 2-[3-(3-chloro-5-cyano-phenoxy)-2-fluoro-4-methyl-phenyl]-N-(2-chloro-4-sulfamoyl-phenyl) - acetamide; 2-[4-bromo-3-(3-chloro-5-cyano«phenoxyr)-2-fluoro-phenyl]-N-(2-chloro-4-sulfamoyl-phenyl)-acetamide; 2-[4-bromo-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-chloro-4-propionylsulfamoyl-phenyl)-acetamide; sodium salt; N-(4-butyiylsiilfamoyl-2-cUoro-phenyl)-2-[4-chloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-acetamide; sodium salt; N- [4-( (S)-2-amino-3-methyl-butyrylsiilfamoyl)-2-chloro-phenyl] -2-[4-chloro-3-(3-chloro-5-c7ano-phenoxy)-2-fluoro-phenyl]-acetamide; sodium salt; N-(2-cMoro-4-sidfamoyl-pheny^ ethyl-2-fluoro-phenyl] -acetamide; 2-[3-(3-q^ano-5-dinuoromeuiyI-phenoxy)-4-etiiyI-2-fluoro-phenyl]-N-( 4-sulfamoyl-phenyl)-acetamide; 2-[4-bromo-3-(3-cUoro-5-c^ano-phenoxy,)-2-fluoro-phenyl]-N-(2-methyl«4-sulfamoyl-phenyl)-acetamide; 2-[4-bromo-3-(3-q^ano-5-difluoromethyl-phenoxy)-2"fluoro-phenyl]-N-(2-methyl-4-sulfamoyl-phenyl)-acetamide; 2-[4-bromo-3-(3-cyano-5-difluoromethyl-phenoxy)-2«fluoro-plienyi]-N-(2-cHoro-4-sulfamoyl-phenyl)-acetamide; 2-[4-chloro-3-(3-cyano-5-difluoromethyl-phenoxy)-2-fluoro-phenyl]-N-(2-methyl-4-sulfamoyl-phenyl)-acetamide; 2-[3-(3"cUoro-5-q^ano-phenox^)-2-fluoro-4-methoxy-phenyl]-N-(2"Chloro--4-sulfamoyl-phenyl)-acetamide; 2-[3-(3 2-[3-(3 wherein in each case the compound can either be a salt or a neutral form of the above. (vi) A compound according to formula la wherein X1 is -O-; R]andR2 are each independently selected from the group consisting of hydrogen, Q.6 alkyl, Ci-ehaloalkyl, C3.8 cycloalkyl, Q^ alkoxy, Q_6 alkylthio, C\.6 alkylsulfinyl, Q_6 sulfonyl, Q-e haloalkoxy, Q-e haloalkylthio, halogen, amino, alkylamino, dialkylamino, aminoacyl, nitro and cyano; or, (ii) together R1 and R2 are -0-CH=CH- or -0-CH2CH2- provided that R1 is not hydrogen; R and R are independently selected from the group consisting of hydrogen, Q.6 alkyl, Ci-6 haloalkyl, Q.6 alkoxy, Ci-6 haloalkoxy Ci_6 alkylthio, Cw haloalkylthio, halogen, amino, nitro and cyano; R5 is aryl substituted -with one to three substituents independently selected from the group consisting of C^ alkyl, C2.6 alkenyl, C2-6 alkynyl, -OCCH2OH, -CCH2NMe2, Cu haloalkyl, C3.8 cycloalkyl, cw alkoxy, Q* alkylthio, Cw alkylsulfinyl, Q^ sulfonyl, Q-e haloalkoxy, C^ haloalkylthio, hydroxy, halogen,, nitro and cyano> said alkyl and said cycloalkyl are optionally substituted with one or two substituents independently selected from the group consisting of alkyl, hydroxy, alkoxy, thiol, alkylthio, halogen, amino, alkylamino, dialkylamino, amino alkyl, alkylaminoalkyl, and dialkylamino; Ar is a substituted phenyl ring according to formula Ila with the proviso that R7a and R7c are not both hydrogen or if R7c is hydrogen, then R7a is chlorine: R7a is selected from the group consisting of hydrogen, Q-e alkyl, C1.3 haloalkyl, C1-6 alkoxy, Cue haloalkoxy, halogen and cyano; R7b is independently selected from the group consisting of Ci-6 haloalkyl, Q^ alkoxy, C1-6 alkylthio, Q.6 alkylsulfinyl, Ci-6 sulfonyl, amino C« alkylsulfonyl, S02NRUaRub, Cue haloalkoxy, Q_6 haloalkylthio, hydroxy, amino, Ci_6 alkylamino, C1-6 dialkylamino, aminoacyl, acyl, CONR8R9, nitro, cyano, Ci-6 heteroalkoxy, -X2(CH2)pS(0)2NR8R9, -X2(CH2)pNHC(0)NHR8R9, -X2(CH2)pNHS(0)2NR8R9 and -X2(CH2)pNHCOOR1Q; R7c is selected from the group consisting of Ci-6 heteroalkoxy, -S(0)2NR8R9, .X2CH2(CH2)pS(0)2NR8R9; -X2(CH2)pNHC(0)NHR8R9, X6(CH2)vCONR8R9, -S02R13, -NR8R9, X2(CH2)pNRnS(0)2NR8R9, -X2(CH2)pNHCOOR10, .X6(CH2)vCOOR10, -X6(CH2)VCN, -OR15 and C(=0)CH2N[(CH2)2]2X4; R8 and R9 taken independently, one of R8 and R9 is hydrogen or Q_6 alkyl and the other of R8 and R9 is selected from the group consisting of hydrogen, -C(=0)R14, -C(=0)CR12NH2, -(CH2)2N[(CH2)2]20, COC02Me, CM cycloalkyl said cycloalkyl optionally substituted with one or two hydroxyl substituents, pyranyl, Q.g alkyl and aryl said alkyl and said aryl groups optionally substituted with one or two substituents independently selected from the group consisting of hydroxy, Q-6 alkoxy, thiol, Q-6 alkylthio, Q_6 alkylsulfinyl, C^ sulfonyl, and halogen; or, taken together are (CH2)2-X5-(CH2)2, -(CH2)0- or (CH2)rS(0)n optionally substituted with one or two substituents selected from the group consisting of halogen, hydroxyl andNRmRub; R10 is CM alkyl; Ru is hydrogen or Q-6 alkyl; Rlla and Rnb are independently Ru; R12 is the sidechain of a naturally occurring D-amino acid; R13 is Q-6 alkyl; -(CH2)sC02Rn, -(CH2)2CN, -(CH2)2NH2, -(CH2)uOH; R14 is CM0 alkyl, -(CH2)sNHRUaRub, -(CH2),ORu, -CH2CH(OH)CH3, -CH2N[(CH2)2]20, -(CH2)2C02Ru, optionally substituted phenyl or pyridinyl; R15 is Q-6 alkyl substituted with one to three hydroxyl groups; X2 is -O- or a bond; X4 is -O- or -NMes X5 is-0-,-S(0)n~orNRu; X6 is -O- or -S(0)D-; m is an integer from 0 to 2; n is an integer from 0 to 2; o is an integer from 4 to 6; p is an integer from 0 to 6; r is an integer from 3 to 4 s is an integer from 1 to 2; u is an integer from 2 to 3; v is an integer from 2 to 6; and, hydrates, solvates, and acid addition salts or salts of the conjugate base thereof. (vii) Compound of formula la according to (vi), wherein X1 is -O-; Rl and R* are each independently selected from the group consisting of hydrogen* Cue alkyl, Q-6 alkoxy and halogen; or together R1 and R2 are -0-CH=CH-, provided that R1 is not hydrogen; R3 and R4 are independently selected from the group consisting of hydrogen, and halogen; R5 is aryl substituted with one to three substituents independently selected from the group consisting of CM alkyl, -OCCHaOH, -OCCH2NMe25 Q_6 haloalkyl, Ci-6 haloalkoxy, cyano and halogen; AT is a substituted phenyl ring according to formula Ila with the proviso that R7a and R7c are not both hydrogen or if R7c is hydrogen, then R7a is chlorine: R7a is selected from the group consisting of hydrogen, Q-6 alkyl, Q.3 haloalkyl, Q.6 alkoxy, Q-6 haloalkoxy, halogen and cyano; R7b is independentiy selected from the group consisting of Q-e haloalkyl, Q.$ alkoxy, Ci_6 alkylthio, Q-6 alkylsulfinyl, C^ sulfonyl, amino Ci-6 alkylsulfonyl, S02NRUaRub, Ci-6 haloalkoxy, Q.6 haloalkylthio, hydroxy, amino, Q_6 alkylamino, Ci-e dialkylamino, aminoacyl, acyl, CONR R , nitro, cyano, Q.6 heteroalkoxy, -X2(CH2)pS(0)2NR8R9, -X2(CH2)pNHC(0)NHR8R9> -X2(CH2)pNHS(0)2NR8R9 and -X2(CH2)PNHCOOR!0; R7c is selected from the group consisting of Ci_6 heteroalkoxy, -S(0)2NR8R9s -X2CH2(CH2)pS(0)2NR8R9; OC2(CH2)pNHC(0)NHR8R9, X6(CH2)vCONR8R9, -S02R13, -NR8R9, X2(CH2)pNRnS(0)2NR8R9, -X2(CH2)pNHCOOR10, Ot6(CH2)vCOOR10, -X6(CH2)VCN, -OR15 and C(=0)CH2N[(CH2)2]2X4; R8 and R9 taken independently, one of R8 and R9 is hydrogen or Q-e alkyl and the other of R8 and R9 is selected from the group consisting of hydrogen, -C(=0)R14, -C(=0)CR12NH2, -(CH2)2N[(CH2)2]20, COC02Me, C3.8 cycloalkyl said cycloalkyl optionally substituted with one or two hydroxy! substituents, pyranyl, Q.6 alkyl and aryl said alkyl and said aryl groups optionally substituted with one or two substituents independently selected from the group consisting of hydroxy, Ci-6 alkoxy, thiol, Q-6 alkylthio, Q-6 alkylsulfinyl, Q-g sulfonyl, and halogen; or, taken together are (CH2)2-X5-(CH2)2, -(CH2)0- or (CH2)rS(0)n optionaUy substituted with one or two substituents selected from the group consisting of halogen, hydroxyl and NRUaRub; R10 is Q.6 alkyl; R11 is hydrogen or Q-6 alkyl; RUa and Rnb are independently R11; R12 is the sidechain of a naturally occurring a-amino acid; R13 is CM alkyl; -(CH2)5C02Rn, -(CH2)2CN, -(CH2)2NH2, -(CH2)uOH; R14 is Cwo alkyl, -(CH2)sNHRIlaRub, -(CH2)sORu, -CH2CH(OH)CH3, -CH2N[(CH2)2]20, -(CH2)2C02Ru, optionally substituted phenyl or pyridinyl; R15 is Ci_6 alkyl substituted with one to three hydroxyl groups; X2 is -O- or a bond; X4 is -O- or -NMes X5 is-0-,-S(0)n-orNRn; X6 isO-or-S(0)n-; m is an integer from 0 to 2; n is an integer from 0 to 2; o is an integer from 4 to 6; p is an integer from 0 to 6; r is an integer from 3 to 4 s is an integer from 1 to 2; u is an integer from 2 to 3; v is an integer from 2 to 6; and, hydrates, solvates, and acid addition salts or salts of the conjugate base thereof. (viii) Compound of formula la according to (vi), wherein X1 is -0-; -S02NHCOCH2OH, -S02NHCOCH2CH2COOH, -S02CH2COOH, -SOsCH.CHzCOOH, -S02CH3, -S02CH2CH2NH2, -S02CH2CH2CN, -SOsCH.CH.CI^OH, Ru is hydrogen or methyl; and hydrates, solvates, and acid addition salts or salts of the conjugate base thereof. (xi) Compound of formula la according to claim 6, which is 2«[4-Chloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-chloro-4-sulfamoyl-phenyl) - acetamide; 2-[4-Chloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-chloro-4-propionylsulfamoyl-phenyl)-acetamide; sodium salt; 2-[3-(3-Chloro-5-cyano-phenoxy)-2-fluoro-4-methyl-phenyl]-N-(2-chloro-4-sulfamoyl-phenyl) -acetamide; 2-[4-Bromo-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-chloro-4-sulfamoyl-phenyl) -acetamide; 2-[4-Bromo-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-chloro-4-propionylsulfamoyl-phenyl)-acetamide; sodium salt; N-(4-Buiyrylsiilfamoyl-2-chloro-phenyl)-2-[4-chloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-acetamide; sodium salt; N-[4-((S)-2-Amino-3-methyl-butyrylsulfamoyl)-2-chloro-phenyl]-2-[4-chloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-acetamide; sodium salt; N-(2-Chloro-4-sulfamoyl-phenyl)-2-[3-(3-cyano-5-difluoromethyl-phenoxy)-4-ethyl-2-fluoro-phenyl] -acetamide; 2-[3-(3-Cyano-5-difluoromethyl-phenoxy)-4-ethyl-2-fluoro-phenyI]-N-(2-methyl-4-sulfamoyl-phenyl)-acetamide; 2-[4-Bromo-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-methyl-4-sulfamoyl-phenyl) - acetamide; 2-[4-lfromo-3-(3-cy7mo-5-uiflttorometh^^ methyl-4-sirtfamoyl-phenyl)-acetamide; 2«[4-Bromo-3-(3-cyano-5-difluoromethyl-phenoxy)-2-fluoro-phenyl]-N-(2-cMoro-4-sulfamoyl-phenyl)-acetamide; 2-[4-CUoro-3-(3-q^ano-5-difluorometiiyl-phenoxy)-2-fluoro-phenyl]-N-(2-methyl-4-sulfamoyl-phenyl)-acetamide; 2-[3-(3-Chloro-5-cyano-plienoxy)-2-fluoro--4-niethoxy-phenyl]-N-(2-cliloro«4-sulfamoyl-phenyl)-acetamide; 2-[3"(3-CUoro-5-q^ano-phenoxy)-2-fluoro-4-methoxy-phenyl]-N-(2-methyl-4-sulfamoyl-phenyl)-acetamide; or, 2-[3-(3-CUoro-5-cj^ano-phenoxy)-2-fluoro-4-metiiyl-phenyl]-N-(2-chloro-4-propionylsulfamoyl-phenyl)-acetamide; sodium salt. (x) Compound of formula la according to any one of claims (vi) to (ix) for use as medicament. (xi) Use of the compound of formula la according to any one of (vi) to (ix) for the manufacture of a medicament for the treatment of diseases mediated by the human immunodeficiency virus (HIV) (xii) A pharmaceutical composition comprising a pharmaceutically effective amount of compound or a pharmaceutically acceptable salt thereof as defined in any one of (i) to (xi) and a pharmaceutical inert carrier. (xiiii) A pharmaceutical composition according to (xii) for the use in the treatment of diseases mediated by the human immunodeficiency virus (HIV). i The phrase "a" or "an" entity as used herein refers to one or more of that entity, for example, a compound refers to one or more compounds or at least one compound. As such, the terms "a" (or "an"), "one or more", and "at least one" can be used interchangeably herein. The phrase "as defined hereinabove" refers to the first definition provided in the Summary of the Invention. The term "optional" or "optionally" as used herein means that a subsequently described event or circumstance may, but need not, occur, and that the description includes instances where the event or circumstance occurs and instances in which it does not For example, "optionally substituted" means that the moiety may be hydrogen or a substituent. The term "Ci-6 alkyl" as used herein denotes an unbranched or branched chain, saturated, monovalent hydrocarbon residue containing 1 to 6 carbon atoms. Examples of alkyl groups include, but are not limited to, lower alkyl groups include methyl, ethyl, propyl, i-propyl, n-butyl, i-butyl, t-butyl or pentyl, isopentyl, neopentyl, hexyl. The term "haloalkyl" as used herein denotes an unbranched or branched chain alkyl group as defined above wherein 1,2,3 or more hydrogen atoms are substituted by a halogen. Examples are 1-fluoromethyl, 1-chloromethyl, 1-bromomethyl, 1-iodomethyl, trifluoromethyl, trichloromethyl, tribromomethyl, triiodomethyl, 1-fluoroethyl, 1-chloroethyl, 1-bromoethyl, 1-iodoethyl, 2-fluoroethyl, 2-chloroethyl, 2-bromoethyl, 2-iodoethyl, 2,2-dichloroethyl, 3-bromopropyl or 2,2,2 -trifluoroethyL The term "C3-8 cycloalkyr as used herein denotes a saturated carbocyclic ring containing 3 to 8 carbon atoms, i.e. cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl or cyclooctyl. The term "aryl" as used herein means a monocyclic or polycyclic-aromatic group comprising carbon and hydrogen atoms. Examples of suitable aryl groups include, but are not limited to, phenyl, tolyl, indenyl, and 1- or 2-naphthyl, as well as benzo-fused carbocyclic moieties such as 5,6,7,8-tetrahydronaphthyL An aryl group can be unsubstituted or substituted with one or more suitable substituents which substituents include Q_6 alkyl, Ci_6 haloalkyl, C3.8 cycloalkyl, Q-6 alkoxy, Ci.6 alkylthio, Ci_6 alkylsulfinyl, Q_6 sulfonyl, C\.$ haloalkoxy, Ci-g haloalkylthio, halogen, amino, alkylamino, dialkylamino, aminoacyl, acyl, alkoxycarbonyl, carbamoyl, N-alkylcarbamoyl, N,N-dialkylcarbamoyl, nitro and cyano. A "heteroaryl group" or "heteroaromatic"as used herein means a monocyclic- or polycyclic aromatic ring comprising up to 15 carbon atoms, hydrogen atoms, and one or more heteroatoms, preferably, 1 to 3 heteroatoms, independently selected from nitrogen, oxygen, and sulfur. As well known to those skilled in the art, heteroaryl rings have less aromatic character than their all-carbon counter parts. Thus, for the purposes of the invention, a heteroaryl group need only have some degree of aromatic character. Illustrative examples of heteroaryl groups include, but are not limited to, pyridinyl, pyridine N-oxide, pyridazinyl, pyrimidyl, pyrazyl, triazinyl, pyrrolyl, pyrazolyl, imidazolyl, (1,2,3,)- and (l,2,4)-triazoIyl, pyrazinyl, pyrimidinyl, tetrazolyl, furyl, thienyl, isoxazolyl, thiazolyl, thienyl, isoxazolyl, indole, indole N-oxide, quinoline, quinoline N-oxide and oxazolyl. A heteroaryl group can be unsubstituted or substituted with one or more suitable substituents selected from hydroxy, oxo, cyano, alkyl, alkoxy, haloalkoxy, alkylthio, halo, haloalkyl, nitro, alkoxycarbonyl, amino, alkylamino, dialkylamino, aminoacyl, alkylsulfonyl, arylsulfinyl, alkoxycarbonyl, carbamoyl, N-alkylcarbamoyl, N,N-dialkylcarbamoyl, acyl unless otherwise indicated. The term "heterocyclyT means the monovalent saturated cyclic radical, consisting of one or more rings, preferably one to two rings, of three to eight atoms per ring, incorporating one or more ring heteroatoms (chosen from N,0 or S(0)o-2)> and which can optionally be substituted with one or more, preferably one to three substituents selected from hydroxy, oxo, cyano, alkyl, alkoxy, haloalkoxy, alkylthio, halo, haloalkyl, nitro, alkoxycarbonyl, amino, alkylamino, dialkylamino, aminoacyl, alkylsulfonyl, arylsulfinyl, alkoxycarbonyl, carbamoyl, N-alkylcarbamoyl, N,N-dialkylcarbamoyl, acyl unless otherwise indicated. Examples of heterocyclic radicals include, but are not limited to, furanyl, tetrahydropyranyl, tetrahydrothiophenyl and the like. A nitrogen atom in the heteroaryl ring can optionally be an N-oxide. The term "alkoxy group" as used herein means an -O-alkyl group, wherein alkyl is as defined above such as methoxy, ethoxy, n-propyloxy, i-propyloxy, «-butyloxy, i-butyloxy, f-butyloxy, pentyloxy, hexyloxy, heptyloxy including their isomers. The term "alkylthio group" as used herein means an -S-alkyl group, wherein alkyl is as defined above such as methylthio, ethylthio, n-propylthio, i-propylthio, n-butylthio, \-butylthio, t-butylthio, pentylthio including their isomers. The term "haloalkoxy group" as used herein means an -O-haloalkyl group, wherein haloalkyl is as defined above. Examples of haloalkoxy groups include, but are not limited to, 2,2,2-trifiuoroethoxy, difluoromethoxy and 1,1,1,3,3,3-hexafluoro-iso-propoxy. The term "haloalkthio group" as used herein means an -S-haloalky! group, wherein haloalkyl is as defined above. An example of haloalkthio group includes, but are not limited to, 2,2,2-trifluoroeththanthiol. The term "aryloxy group" as used herein means an O-aryl group wherein aryl is as defined above. An aryloxy group can be unsubstituted or substituted with one or more suitable substituents. Preferably, the aryl ring of an aryloxy group is a monocyclic ring, wherein the ring comprises 6 carbon atoms, referred to herein as "(C6) aryloxy". The term "optionally substituted aryloxy" means the aryl or group may be substituted with one to three groups selected from the group consisting of Q-e alkyl, Q-e haloalkyl, C3.s cycloalkyl, Ci.6 alkoxy, Ci.6 alkylthio, Q_6 alkylsulfinyl, Ci-6 sulfonyl, Ci-6 haloalkoxy, Q.6 haloalkylthio, halogen, amino, alkylamino, dialkylamino, aminoacyl, acyl, alkoxycarbonyl, carbamoyl, N-alkylcarbamoyl, N,N-dialkylcarbamoyl, nitro and cyano. The term "heteroaryloxy group" as used herein means an O-heteroaryl group, wherein heteroaryl is as defined above. The heteroaryl ring of a heteroaryloxy group can be unsubstituted or substituted with one or more suitable substituents. Examples of heteroaryl groups include, but are not limited to, 2-pyridyloxy, 3-pyrrolyloxy, 3-pyrazolyloxy, 2-imidazolyloxy, 3-pyrazinyloxy, and 4-pyrimidyloxy. The term "acyl" or "alkylcarbonyl" as used herein denotes a radical of formula C(=0)R wherein R is hydrogen, unbranched or branched alkyl containing 1 to 6 carbon atoms or a phenyl group. The term "alkoxycarbonyl" as used herein denotes a radical of formula C(=0)OR wherein R is, unbranched or branched alkyl as described above. The term "acylamino" as used herein denotes a radical of formula -NH-(acyl) where acyl is as defined herein. The term "arylboronic acid" as used herein denotes a radical of formula ArB(OH)2 wherein Ar is an optionally substituted aryl group as described above. The term "alkylene" as used herein denotes a divalent linear or branched saturated hydrocarbon radical, having from one to six carbons inclusive, unless otherwise indicated. Examples of alkylene radicals include, but are not limited to, methylene, ethylene, propylene, 2-methyl-propylene, butylene, 2-ethylbutylene. The term "arylalkyl" or "aralkyl" as used herein denotes the radical R'R"-, wherein R' is an aryl radical as defined herein, and R" is an alkylene radical as defined herein and the arylalkyl group is attached through the alkylene radical. Examples of arylalkyl radicals include, but are not limited to, benzyl, phenylethyl, 3-phenylpropyl. The term "halogen" as used herein means fluorine, chlorine, bromine, or iodine. Correspondingly, the meaning of the term "halo" encompasses fluoro, chloro, bromo, and iodo. The term "hydrohalic acid" refers to an acid comprised of hydrogen and a halogen. The term "alkylsulfinyl" as used herein means the radical -S(0)Rf, wherein R' is alkyl as defined herein. Examples of alkylaminosulfonyl include, but are not limited to methylsulfinyl and i5c?-propylsulfinyl. The term "alkylsulfonyl" as used herein means the radical -S(0)2R', wherein Rf is alkyl as defined herein. Examples of alkylaminosulfonyl include, but are not limited to methylsulfonyl and zso-propylsulfonyl. The terms "amino", "alkylamino" and "dialkylamino" as used herein refer to -NH2, -NHR and -NR2 respectively and R is alkyl as defined above. The two alkyl groups attached to a nitrogen in a dialkyl moiety can be the same or different. The terms "aminoalkyl", "alkylaminoalkyl" and "dialkylaminoalkyl" as used herein refer to NH2(CH2)n-, RHN(CH2)n-, and R2N(CH2)n- respectively wherein n is 1 to 6 and R is alkyl as defined above The prefix "carbamoyl" as used herein means the radical -CONH2. The prefix "N-alkylcabamoyr and 'HN-dialkylcarbamoyl" means the radical CONHR' or CONRrR" respectively wherein the R' and R" groups are independently alkyl as defined herein. The term "amino acid" as used herein refers to naturally occurring amino acids, as well as to optical isomers (enantiomers and diastereomers), synthetic analogs and derivatives thereof. a-Amino acids comprise a carbon atom bonded to a carboxyl group, an amino group, a hydrogen atom and a unique "side chain" group. The term "naturally occurring amino acids" means the L-isomers of the naturally occurring amino acids. The naturally occurring amino acids are glycine, alanine, valine, leucine, isoleucine, serine, methionine, threonine, phenylalanine, tyrosine, tryptophan, cysteine, proline, histidine, aspartic acid, asparagine, glutamic acid, glutamine, a-carboxyglutamic acid, arginine, ornithine and lysine. The side chains of naturally occurring amino acids include: hydrogen, methyl, iso-propyl, iso-butyl, sec-butyl, -CH2OH, -CH(OH)CH3, -CH2SH, -CH2CH2SMe5 -(CH2)PCOR wherein R is -OH or -NH2 and p is 1 or 2, -(CH2)q-NH2 where q is 3 or 4, -(CH2)3-NHC(=NH)NH2, -CH2C6H5, -CH2-p-C6H4-OH, (3-indolinyl)methylene, (4-imidazolyl)methylene. The term "conjugate base" as used herein means the chemical species produced when a proton is abstracted from an acid (including here a carbon acid). Compounds of formula I exhibit tautomerism. Tautomeric compounds can exist as two or more interconvertable species. Prototropic tautomers result from the migration of a covalendy bonded hydrogen atom between two atoms. Tautomers generally exist in equilibrium and attempts to isolate an individual tautomers usually produce a mixture whose chemical and physical properties are consistent with a mixture of compounds. The position of the equilibrium is dependent on chemical features within the molecule. For example, in many aliphatic aldehydes and ketones, such as acetaldehyde, the keto form predominates while; in phenols, the enol form predominates. Common prototropic tautomers include keto/enol (-C(=0)-CH- -C(-NHR)=N-) tautomers. The latter two are particularly common in heteroaryl and heterocyclic rings and the present invention encompasses all tautomeric forms of the compounds. Compounds of formula I which are basic can form pharmaceutical^ acceptable acid addition salts with inorganic acids such as hydrohalic acids (e.g. hydrochloric acid and hydrobromic acid), sulphuric acid, nitric acid and phosphoric acid, and the like, and with organic acids (e.g. with acetic acid, tartaric acid, succinic acid, fumaric acid, maleic acid, malic acid, salicylic acid, citric acid, methanesulphonic acid and p-toluenesulfonic acid, and the like). A "prodrug" of a compound of formula (I) herein refers to any compound which releases an active drug according to Formula I in vivo when such prodrug is administered to a mammalian subject Prodrugs of a compound of Formula I are prepared by modifying one or more functional group(s) present in the compound of Formula I in such a way that the modification(s) may be cleaved in vivo to release the compound of Formula L Prodrugs include compounds of Formula I wherein a hydroxy, amino, or sulfhydryl group in a compound of Formula I is bonded to any group that may be cleaved . in vivo to regenerate the free hydroxy!, amino, or sulfhydryl group, respectively. Examples of produgs include N-acyl-benzenesulfonamide described. The term "solvate" as used herein means a compound of the invention or a salt, thereof, that further includes a stoichiometric or non-stoichiometric amount of a solvent bound by non-covalent intermolecular forces. Preferred solvents are volatile, non-toxic, and/or acceptable for administration to humans in trace amounts. The term "hydrate" as used herein means a compound of the invention or a salt thereof, that further includes a stoichiometric or non-stoichiometric amount of water bound by non-covalent intermolecular forces. The term "clathrate" as used herein means a compound of the invention or a salt thereof in the form of a crystal lattice that contains spaces (e. g., channels) that have a guest molecule (e. g., a solvent or water) trapped within. The term "wild type" as used herein refers to the HIV virus strain which possesses the dominant genotype which naturally occurs in the normal population which has not been exposed to reverse transcriptase inhibitors. The term "wild type reverse transcriptase" used herein has refers to the reverse transcriptase expressed by the wild type strain which has been sequenced and deposited in the SwissProt database with an accession number P03366. The term "reduced susceptibility" as used herein refers to about a 10 fold, or greater, change in sensitivity of a particular viral isolate compared to the sensitivity exhibited by the wild type virus in the same experimental system. The term "nucleoside and nucleotide reverse transcriptase inhibitors" ("NRTFs) as used herein means nucleosides and nucleotides and analogues thereof that inhibit the activity of HTV-1 reverse transcriptase, the enzyme which catalyzes the conversion of viral genomic HIV-1 RNA into proviral HIV-1 DNA. Typical suitable NRTIs include zidovudine (AZT) available under the RETROVIR tradename; didanosine (ddl) available under the VIDEX tradename.; zalcitabine (ddC) available under the HIVID tradename; stavudine (d4T) available under the ZERIT trademark; lamivudine (3TC) available under the EPIVIR tradename; abacavir (1592U89) disclosed in WO96/30025 and available under the ZIAGEN trademark; adefovir dipivoxil [bis(POM)-PMEA] available under the PREVON tradename; lobucavir (BMS-180194), a nucleoside reverse transcriptase inhibitor disclosed in EP-0358154 and EP-0736533 and under development by Bristol-Myers Squibb; BCH-10652, a reverse transcriptase inhibitor (in the form of a racemic mixture of BCH-10618 and BCH-10619) under development by Biochem Pharma; emitricitabine [(-)-FTC] licensed from Emory University under U.S. Pat No. 5,814,639 and under development by Triangle Pharmaceuticals; beta-L-FD4 (also called beta-L-D4C and named beta-L-21,3'-dicleoxy-5-fluoro-cytidene) licensed by Yale University to Vion Pharmaceuticals; DAPD, the purine nucleoside, (-)-beta-D-2,6,-diamino-purine dioxolane disclosed in EP-0656778 and licensed to Triangle Pharmaceuticals; and lodenosine (FddA), 9-(2,3-dideoxy-2-fluoro-b-D-threo-pentofuranosyl)adenine, an acid stable purine-based reverse transcriptase inhibitor discovered by the NIH and under development by U.S. Bioscience Inc. The term "non-nucleoside reverse transcriptase inhibitors" ("NNRTT's) as used herein means non-nucleosides that inhibit the activity of HTV-1 reverse transcriptase. Typical suitable NNRTIs include nevirapine (BI-RG-587) available under the VIRAMUNE tradename; delaviradine (BHAP, U-90152) available under the RESCRIPTOR tradename; efavirenz (DMP-266) a benzoxazin-2-one disclosed in WO94/03440 and available under the SUSTIVA tradename; PNU-142721, a furopyridine-thio-pyrimide; AG-1549 (formerly Shionogi # S-1153); 5-(3,5-dicUorophenyl)-thio-4-isopropyl-l-(4-pyridyl)methyl-lH-imidazol-2-ylmethyl carbonate disclosed in WO 96/10019; MKC-442 (l-(ethoxy-methyl)-5-(l-methylethyl)-6-(phenylmethyl)-(2,4(lH,3H)-pyrimidinedione); and (+)-calanohde A (NSC-675451) and B, coumarin derivatives disclosed in U.S. Pat. No. 5,489,697. The term "protease inhibitor" ("PI") as used herein means inhibitors of the HIV-1 protease, an enzyme required for the proteolytic cleavage of viral polyprotein precursors (e.g., viral GAG and GAG Pol polyproteins), into the individual functional proteins found in infectious HIV-1. HIV protease inhibitors include compounds having a peptidomimetic structure, high molecular weight (7600 daltons) and substantial peptide character, e.g. CRIXTVAN as well as nonpeptide protease inhibitors e.g., VIRACEPT. Typical suitable Pis include saquinavir available in hard gel capsules under the INVLRASE tradename and as soft gel capsules under the FORTOVASE tradename; ritonavir (ABT-538) available under the NORVIR tradename; indinavir (MK-639) available under the CRDQVAN tradename; nelfhavir (AG-1343) available under the VIRACEPT; amprenavir (141W94), tradename AGENERASE, a non-peptide protease inhibitor; lasinavir (BMS-234475; originally discovered by Novartis, Basel, Switzerland (CGP-61755); DMP-450, a cyclic urea discovered by Dupont; BMS-2322623, an azapeptide under development by Bristol-Myers Squibb, as a 2nd-generation HTV-1 PI; ABT-378; AG-1549 an orally active imidazole carbamate. Other antiviral agents include hydroxyurea, ribavirin, IL-2, IL-12, pentafuside and Yissum Project No. 11607. Hydroxyurea (Droxia), a ribonucleoside triphosphate reductase inhibitor, the enzyme involved in the activation of T-cells. Hydroxyurea was shown to have a synergistic effect on the activity of didanosine and has been studied with stavudine. IL-2 is disclosed in Ajinomoto EP-0142268, Takeda EP-0176299, and Chiron U.S. Pat Nos. RE 33,653,4,530,787,4,569,790,4,604,377,4,748,234,4,752,585, and 4,949,314, and is available under the PROLEUKIN (aldesleukin) tradename as a lyophilized powder for IV infusion or sc administration upon reconstitution and dilution with water; a dose of about 1 to about 20 million lU/day, sc is preferred; a dose of about 15 million 1 U/day, sc is more preferred. IL-12 is disclosed in W096/25171 and is available as a dose of about 0.5 microgram/kg/day to about 10 microgram/kg/day, sc is preferred. Pentafuside (DP-178, T-20) a 36-amino acid synthetic peptide, disclosed in U.S. Pat. No. 5,464,933 and available under the FUZEON tradename; pentafuside acts by inhibiting fusion of HIV-1 to target membranes. Pentafuside (3-100 mg/day) is given as a continuous sc infusion or injection together with efavirenz and 2 PI!s to HIV-1 positive patients refractory to a triple combination therapy, use of 100 mg/day is preferred. Yissum Project No. 11607, a synthetic protein based on the HIV-1 Vif protein. Ribavirin, l-,beta.-D-ribofuranosyl-lH-l,2,4-triazole-3--carboxamide, is described in U.S. Pat No. 4,211,771. The term "anti-HIV-1 therapy" as used herein means any anti-HIV-1 drug found useful for treating HIV-1 infections in man alone, or as part of multidrug combination therapies, especially the HAART triple and quadruple combination therapies. Typical suitable known anti-HTV-1 therapies include, but are not limited to multidrug combination therapies such as (i) at least three anti-HTV-1 drugs selected from two NRTIs, one PI, a second PI, and one NNRTI; and (ii) at least two anti-HTV-1 drugs selected from NNRTIs and Pis. Typical suitable HAART—multidrug combination therapies include: (a) triple combination therapies such as two NRTIs and one PI; or (b) two NRTIs and one NNRTI; and (c) quadruple combination therapies such as two NRTIs, one PI and a second PI or one NNRTI. In treatment of naive patients, it is preferred to start anti-HTV-1 treatment with the triple combination therapy; the use of two NRTIs and one PI is preferred unless there is intolerance to Pis. Drug compliance is essential. The CD4+ and HTV-1-RNA plasma levels should be monitored every 3-6 months. Should viral load plateau, a fourth drug, e.g., one PI or one NNRTI could be added. Abbreviations used in this application include: acetyl (Ac), acetic acid (HOAc), azo-fcis-isobutyrylnitrile (AIBN), 1-N-hydroxybenzotriazole (HOBT), atmospheres (Atm), high pressure liquid chromatography (HPLC), 9-borabicyclo[3.3.1]nonane (9-BBN or BBN), methyl (Me), tert-butoxycarbonyl (Boc), acetonitrile (MeCN), di-tert-butyl pyrocarbonate or boc anhydride (BCX^O), l-(3-dimethylaminopropyI)-3-ethylcarbodiimide hydrochloride (EDCI), benzyl (Bn), m-chloroperbenzoic acid (MCPBA), butyl (Bu), methanol (MeOH), benzyloxycarbonyl (cbz or Z), melting point (mp), carbonyl diimidazole (CDI), MeSCh- (mesyl or Ms), l,4-diazabicyclo[2.2.2]octane (DABCO), mass spectrum (ms) diethylaminosulfor trifluoride (DAST), methyl f-butyl ether (MTBE), dibenzylideneacetone (Dba), N-carboxyanhydride (NCA), 1,5-diazabicyclo[4.3.0]non-5-ene (DBN), N-bromosuccinimide (NBS), 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), N-methylpyrrolidone (NMP), 1,2-dichloroethane (DCE), pyridinium chlorochromate (PCC), N,N!-dicyclohexylcarbodiimide (DCC), pyridinium dichromate (PDC), dichloromethane (DCM), propyl (Pr), diethyl azodicarboxylate (DEAD), phenyl (Ph), di-iso-propylazodicarboxylate, DIAD, pounds per square inch (psi), diethyl iso-propylamine (DEIPA), pyridine (pyr), di-iso-butylaluminumhydride, DIBAL-H, room temperature, rt or RT, N,N-dimethyl acetamide (DMA), fert-butyldimethylsilyl or t-BuMe2Si, (TBDMS), 4-N,N-dimethylaminopyridine (DMAP)> triethylamine (Et3N or TEA), N>N-dimethylformamide (DMF), triflate or CF3S02- (Tf), dimethyl sulfoxide (DMSO), trifluoroacetic acid (TFA), l,l!-&is-(diphenylphosphino)ethane (dppe), 2,2,6,6-tetramethylheptane-2,6-dione (TMHD), l,l'-&?5-(diphenylphosphino)ferrocene (dppf), thin layer chromatography (TLC), ethyl acetate (EtOAc), tetrahydrofiiran (THF), diethyl ether (Et20), trimethylsilyl or Me3Si (TMS), ethyl (Et), p-toluenesulfonic acid monohydrate (TsOH or pTsOH), lithium hexamethyl disilazane (LiHMDS), 4-Me- C6H4SOr or tosyl (Ts), iso-propyl O'-Pr), N-urethane-N-carboxyanhydride (UNCA), ethanol (EtOH). Conventional nomenclature including the prefixes normal («), iso (£•)» secondary (sec-), tertiary (tert-) and neo have their customary meaning when used with an alkyl moiety. (J. Rigaudy and D. P. Klesney, Nomenclature in Organic Chemistry, IUPAC 1979 Pergamon Press, Oxford.). COMPOUNDS AND PREPARATION Examples of representative compounds encompassed by the present invention and within the scope of the invention are contained in the Table 1. The compounds in Table 1 and the preparative examples which follow are provided to enable those skilled in the art to more clearly understand and to practice the present invention. They should not be considered as limiting the scope of the invention, but merely as being illustrative and representative thereof. In general, the nomenclature used in this Application is based on AUTONOM™ v*4.0, a Beilstein Institute computerized system for the generation of IUPAC systematic nomenclature. If there is a discrepancy between a depicted structure and a name given that structure, the depicted structure is to be accorded more weight. In addition, if the stereochemistry of a structure or a portion of a structure is not indicated with, for example, bold or dashed lines, the structure or portion of the structure is to be interpreted as encompassing all stereoisomers of it Compounds of the present invention can be made by a variety of methods depicted in the illustrative synthetic reaction schemes shown and described below. The starting materials and reagents used in preparing these compounds generally are either available from commercial suppliers, such as Aldrich Chemical Co., or are prepared by methods 5 known to those skilled in the art following procedures set forth in references such as Fieser and Fieser's Reagents for Organic Synthesis; Wiley & Sons: New York, Volumes 1-21; R. C. LaRock, Comprehensive Organic Transformations, 2n edition Wiley-VCH, New York 1999; Comprehensive Organic Synthesis} B. Trost and I. Fleming (Eds.) vol. 1-9 Pergamon, Oxford, 1991; Comprehensive Heterocyclic Chemistry, A. R. Katritzky and C W. Rees (Eds) Pergamon, Oxford 1984, vol. 1-9; Comprehensive Heterocyclic Chemistry II, A. R. Katritzky and C. W. Rees (Eds) Pergamon, Oxford 1996, vol. 1-11; and Organic Reactions) Wiley & Sons: New York, 1991, Volumes 1-40. The following synthetic reaction schemes are merely illustrative of some methods by which the compounds of the present invention can be synthesized, and various modifications to these synthetic reaction schemes can be made and will be suggested to one skilled in the art having referred to the disclosure contained in this Application. The starting materials and the intermediates of the synthetic reaction schemes can be isolated and purified if desired using conventional techniques, including but not limited to, filtration, distillation, crystallization, chromatography, and the like. Such materials can be characterized using conventional means, including physical constants and spectral data. Unless specified to the contrary, the reactions described herein preferably are conducted under an inert atmosphere at atmospheric pressure at a reaction temperature range of from about -78 °C to about 150 °C, more preferably from about 0°C to about 125 °C, and most preferably and conveniently at about room (or ambient) temperature, e.g., about 20 °C Some compounds in following schemes are depicted with generalized substituents; however, one skilled in the art will immediately appreciate that the nature of the R groups can varied to afford the various compounds contemplated in this invention. Moreover, the reaction conditions are exemplary and alternative conditions are well known. The reaction sequences in the following examples are not meant to limit the scope of the invention as set forth in the claims. N-Phenyl 3-phenoxy-phenylacetamide compounds are prepared from phenyl acetic acid derivatives 4 (X1 = O, R5 = optionally substituted phenyl) as depicted in Scheme 1. The preparation of phenylacetic acids related to the present compounds have been described in US Serial Nos. 10/807,993 and 10/807,766 entitled Non-nucleoside Reverse Transcriptase Inhibitors filed March 23,2004 These applications are hereby incorporated by reference in their entirety. 4-AJkyl-3-aryloxy-phenylacetic add compounds are useful precursors to some embodiments of the present invention and can be prepared from 4-hydroxy-3-methoxyphenyl acetate by Pd catalyzed coupling of a dialkyl zinc species and ethyl 3-methoxy-4-trifluorosulfonyloxy-phenylacetate (4b) to produce the corresponding 4-alkyl compound (SCHEME 1). The Negishi coupling of organozinc halides or dialkylzinc with haloarenes and aryl triflates is an effective means for attachment of an alkyl group to an arene (E.-I. Negishi, Ace. Chem. Res. 1982 15:340-348). The reaction is catalyzed by palladium Pd(0) and palladium is preferably ligated to a bidentate ligand including Pd(dppf)Cl2 and Pd(dppe)Cl2. (J- M. Herbert Tetrahedron Lett. 2004 45:817-819) Typically the reaction is run in an inert aprotic solvent and common ethereal solvents include dioxane, DME and THF are suitable. The reaction is commonly run at elevated temperature. Alternatively Friedel-Crafts acylation of ethyl 3-methoxy-phenylacetate affords 4-acetyl-3-methoxy-phenylacetate 8. Reduction of the ketone to afford the 4-ethyl derivative 12a can be accomplished under a variety of conditions including triethylsilylhydride/TFA, catalytic hydrogenation and hydrogenolysis, Clemmenson and Wolf-Kischner procedures. Alternatively the side chain can be further elaborated by subjecting the ketone to a Wittig condensation and reduction of the resulting olefin. In the present invention triphenylphosphonium methylide is condensed with 8 affording ethyl 4-isopropenyl-3-mefhoxy-phenylacetate (14) which was reduced to the corresponding ethyl 4-iso-propyl-3-methoxy-phenylacetate (16). One skilled in the art will recognize many closely related alternative procedures are available that afford other 4-alkyl substituents. Demethylation of the methyl ether affords the corresponding ethyl 4-alkyl-3-hydroxyphenylacetate 18a which are useful synthetic intermediates for introduction of the 3-aryloxy moiety. SCHEME 1 3,4-Dimethyl-5-aryloxy-phenylacetic acid compounds were also prepared using a dialkylzinc mediated coupling; however, prior to that coupling the activating effect of the hydroxyl was exploited to formylate the aromatic ring and afford 22a. Reduction of the formyl substituent provides the methyl compound 22c, (SCHEME 2) The formyl moiety provides a versatile intermediate that can be further modified to incorporate a variety of substitution into the 3-position. Demethylation of the methyl ether affords the phenol 24c which can be used to introduce the biaryl ether linkage. The preparation of diaryl ethers has been reviewed (J. S. Sawyer, Recent Advances in Diaryl Ether Synthesis, Tetrahedron 2000 56:5045-5065). Introduction of the (hetero)aryloxy ether can often be accomplished by direct SnAr displacement reaction on a aromatic ring bearing a leaving group and electronegative substituents. Fluoroaromatic compounds with electronegative substituents are known to be sensitive to nucleophilic attack by soft nucleophiles. Fluorine substituents are generally significantly more labile than other halogen substituents. While hard nucleophiles like water and hydroxide fail to displace fluoride, soft nucleophiles like phenols, imidazoles, amines, thiols and some amides undergo facile displacement reactions even at room temperature (D. Boger et ah, Biorg. Med. Chem. Lett. 2000 10:1471-75; F. Terrier Nucleophilic Aromatic Displacement: The Influence of the Nitro Group VCH Publishers, New York, NY 1991). Phenols typified by 6b and 12a can be treated with appropriately substituted aryl fluorine compounds to produce diaryl ethers(m/ra}. Aryl ethers also can be efficiently prepared by Cu(OAc)2 catalyzed condensation of substituted benzene boronic acids and phenols (D. A. Evans et al, Tetrahedron Lett., 1998 39:2937-2940 and D. M. T. Chan et al, Tetrahedron Lett. 1998 39:2933-2936). This protocol can also be adapted to phenols such as 6b and 12a. Substituted benzene boronic acids with a variety of other substituents are widely available. Alternatively, variations of the Ullmann diaryl ether synthesis with Cu(I) salts (J.-F. Marcoux et al.y /. Am. Chem. Soc 1997 119:10539-540; E. Buck et al Org. Lett. 2002 4(9):1623-1626) or palladium-catalyzed coupling procedures also has been reported (G. Mann et al, I Am. Chem. Soc, 1999 121:3224-3225) have been described. One skilled in the art will appreciate that optimal procedure will vary depending on the nature and position of substituents on the aryl rings to be coupled and useful conditions for the coupling can by identified without undue experimentation. 5-Methyl- and 5-ethyl-3-hydroxy-phenylacetic derivatives were prepared by monomethylation of 3,5-dihydxoxy-phenylacetic acid to afford 26a followed sequentially by treatment with triflic anhydride and dialkylzinc/Pd[P(Ph)3]4 mediated coupling to afford 28a and 28b. While the reactions are illustrated with methyl and ethyl groups, one skilled in the art will appreciate that a variety of substitutents can be introduced depending on the reagent selected. Demethylation of the methyl ether was accomplished as previously described to afford phenols that can be used to introduce the diaryl ethers. 3-Aiyloxy-5-methoxy-phenylacetic acids compounds can be prepared by mono-arylation of alkyl 3,5-dihydroxy-phenylacetates and subsequent methylation to afford 34b (SCHEME 3). Other alkoxy compounds are readily prepared by replacing methyl iodide with other alkylating agents. While useful substituted phenylacetic acid precursors are sometimes available, an alternative route utilizing methyl substituents to elaborate the acetic acid side chain has been used. Ethyl 4-chloro-3-hydroxy-phenylacetate (40) was prepared from l-chloro-2-methoxy-4-methyl-benzene by benzylic bromination (step 1) and displacement of the bromine atom with sodium cyanide (step 2). Hydrolysis of the nitrile (steps 3 and 4) and demethylation of the ether under standard conditions afforded 40. Demethylations with BBr3 or Lil/syn collidine are effective techniques for conversion of methyl ethers to the corresponding phenols. Incorporation of the aryl or heteroaryl ether is achieved by one of the methods described previously. 4-Chloro-2-fluoro-3-phenoxy-phenylacetic acid compounds (SCHEME 5) can prepared by starting from l-chloro-3-fluoro-2-methoxy-4-methylbenzene which is subjected to benzylic bromination with NBS and AIBN, cyanide displacement, hydrolysis of the nitrile and esterification of the carboxylic acid utilizing a sequence analogous to that described in SCHEME 4 SCHEME 5 Alternatively, the synthesis of 2-fluoro substituted compounds can be accomplished by exploiting the facile displacement of fluoroaromatic compounds. Thus, treatment of l,2,3-triflouro-4-nitro-benzene (46) with an alkali metal phenolate resulted in displacement of the 3-fluoro group with good regioselectivity to afford 48a (SCHEME 6). Treatment of 48a with carbanion formed by deprotonation of ferf-butyl ethyl malonate results in the regioselective introduction of a malonic ester (48b) which is subjected to acid-catalyzed hydrolysis of the tert-butyl ester and decarboxylation to afford 48c. After introduction of the phenoxy and acetic acid moieties, the nitro group is readily converted to other substituents at the 4-position. Reduction of the nitro substituent to the corresponding amine 50a which can be subjected to Sandmeyer reactions. In the present case, the Sandmeyer reaction was used to introduce a bromo 50a or chloro 50e substituent The bromo substituent could be further reacted with a dialkyi zinc (the Negishi Reaction) to afford 4-alkyl-3-aryloxy-2-fluoro-phenylacetic acid compounds exemplified by 50c and 50d. 52b which also is an effective substrate for introduction of an aryl ether and Sandmeyer-type chemistry 4-Alkoxy-2-fiuoro-3-phenoxy^henylacetic acid compounds are prepared by a alternate route. A mixture ortfzo-difluorobenzene (54a) and trimethylsilyichloride was treated with butyl lithium which afforded 2,3-difluoro-l54-&f5-trimethylsilanyl-benzene (54b) which was brominated to afford 54c. Selective monometallation of 54c with iso-propylmagnesium chloride-lithium chloride complex and quenching the organomagnesium compound with DMF afforded 54d. Reaction of 54d with a phenol in the presence of K2CO3 resulted in displacement of the fluorine atom adjacent to the aldehyde to afford 56a. The aldehyde was subjected to a Baeyer-VUliger oxidation with trifluoroperacetic acid which underwent concomitant hydrolysis to the phenol 56b which was alkylated with CS2CO3 and methyl iodide to afford the methoxy substituted analog 56c. Metallation of the remaining bromine substituent with iso-PrMgCl/Lil/THF and alkylation of the resulting Grignard reagent afforded 58a which was oxidatively cleaved with NaI04/Ru(III)Cl3 to produce the phenylacetic acid 58b and converted to the corresponding amides by procedures described previously. The substituted phenylacetic acid esters thus obtained were converted to the corresponding amides through a three-step sequence including hydrolysis of the ester, conversion of the resulting acid to an acid chloride and condensation of the acid chloride with an aryl amine or heteroarylamine. Fluorine-substituted aromatic compounds which are useful intermediates for formation of the biaryl ether are commercially available or readily prepared from commercially available precursors. 3-Chloro-5-fluoro-benzonitrile (59a), l-bromo-3-chloro-5-fluorobenzene, l-bromo-2-fluoro-4-chloro~benzene, 4-chloro-3-fluorobenzonitrile, 3-fluoro«5-trifluoromethyl-benzonitrile (59b), 3,5-dibromo-fluoro-benzene, l,3-dichloro-2-fiuorobenzene (59c), l,4-dichloro-2-fluoro-6-bromo-benzene (59d), l-chloro-2-fluoro-4,6-dibromo-benzene (59e)and l-chloro-2,6-difluoro-4-bromo-benzene (59f) were purchased. Cyanide substituents can be introduced into a aromatic ring by Zn(CN)2/palladium-catalyzed displacement of a halogen by cyanide which can be carried out either after after formation of the biaryl ether or on a halogenated precursor (SCHEME 8 - reaction B). Fluoroalkyl substituted compounds are useful embodiments of the invention and 66 and 72c were prepared by fluorination of a carbonyl compound with a fluorinating agent such as (diethylamino)sulfur trifluoride (DAST) or [bis(2-methoxyethylamino)sulfur difluoride (Deoxo-Fluor*). Thus l,3-dibromo-5- fluorobenzene (64a) was mono-metallated and formylated to afford 64b. Fluorination of 64b with DAST afforded 64c which was optionally treated with Zn(CN)2 and Pd[P(Ph)3]4 to introduce a nitrile prior to formation of the fczs-aryl ether 68 by condensation of 66 and 52b. The 1,1,-difluoroethyl substituent was introduced utilizing an analogous strategy whereby an acetyl derivative was fluorinated with Deoxo-Fluor . The acetyl compound 72b was obtained by mono-metallation of 70 and quenching with N-methyl-N-(methoxy)acetamide. The fully elaborated phenylacetic acid 74 was obtained by condensation of 72c and 52b followed Sandmeyer reaction in the presence of Cu(I)Cl and HC1. Optional introduction of a cyanide into the aryl ring (step 7) was carried out as described previously. Di-cyano substitution is another feature in some embodiments of the present invention and dicyano aromatic compounds, e.g.t 80 are readily available by kzVcyanation of a dihalo precursor 78. One skilled in the art will appreciate this transformation can be carried out on a variety of dihalogenated substrates. Considerable flexibility in the sequence of the transformations is possible and fcis-cyanation can be carried out either prior to or after formation of the biaryl ether, e.g., transformation of 82a to 82b. In some examples of the present invention the biaryl ether is introduced by reacting a suitably substituted phenol and a fluoro-substituted phenylacetic acid or precursor thereof, (see SCHEME 6) Many useful phenols are commercially available. 3-Chloro-5-hydroxy-benzonitrile (81c) was a useful intermediate in the synthesis of some embodiments of the present invention. 81c was conveniently prepared from 3,5-dichlorobenzonitrile (81a) by displacement of one chlorine substituent with sodium methoxide and Lil/collidine mediated demethylation of the resulting arylmethyl ether 81b. The phenol was reacted with 46 to afford 83a which was further transformed to 83c as described previously. Introduction of haloalkoxy substituents were readily accomplished by addition of a dihalocarbene to a phenol. 3,5-Dihydroxy-benzonitrile (84a) is transformed into the base-stable mono SEM-ether 84c which is reacted with difluorocarbene generated by decarboxylative elimination of difluorochloroacetic acid (SCHEME 10). Deprotection and condensation of the resulting phenol 86b with ethyl 2,3-difluoro-4-nitro-phenylacetate 52b affords 88 which can be further converted to compounds of the present invention. SCHEME 11 Other embodiments of the invention include N-acylsulfonamides (SCHEME 11) which can be prepared by acylation of the corresponding sulfonamide. The acylation can be achieved by reacting the sulfonamide with acyl halides or anhydrides, e.g. propionyl anhydride, or, in the case of acylation with N-protected amino acids, by transient activation of the carboxylic acid followed by condensation with 90a and deprotection. Protocols for activation, coupling and deprotection of amino acids are well known in the art Although the acyl sulfonamides in SCHEME 11 are depicted as neutral molecules, the acidic proton on the acyl sulfonamide nitrogen can be readily deprotonated to form salts. Acyl sulfonamides formed from amino acids can be deprotected by well established procedures and the free amine group can be converted into an acid addition salt Other N-substituted sulfonamides were prepared by amidation with a 4-amino-benzensulfonyl fluoride (95) to afford an intermediate sulfonyl fluoride 114 which is further reacted with a (di)alkylamine to afford the desired sulfonamide derivatives. 4-Amino-benzene-sulfones are useful intermediates for the synthesis of some embodiments of the present invention (SCHEME 13). The requisite anilines were prepared from 4-fluoro-2-methylnitrobenzene. Displacement of the fluoride with sodium sulfide and alkylation of the resulting thiol with ethyl bromoacetamide and oxidation of the thiol to the corresponding sulfone with MCPBA affords 98d. Reduction of the nitro substituent and condensation of the resulting amine 100 with an aroyl chloride affords 122. Subsequent modification of the function groups, e.g„ hydrolysis of the carboxylic acid ester is possible using previously described methodology. Other alkylating agents useful to prepare compounds of the present invention include haloalkanols, e.g. bromoethanol and brompropanol, N-protected halo amines, e.g,> (2-bromo-ethyl)-carbamic acid tert-butyl ester and bromoacetonitrile. The corresponding ether analogs were available by alkylation of the analogous phenols, (see, e.£, P. G. Wyatt etal I Med, Chem. 1995 38(10):1657-1665). (7-Aryloxy-benzofuran-5-yl)-acetic acid derivatives were prepared from (2,3-dihydro-benzofuran-5-yl)-acetic acid ethyl ester (101a). Introduction of the oxygen substituent was achieved by Friedel-Craft acetylation and subsequent Baeyer-Villiger rearrangement and hydrolysis of the acetate to afford lOld. Introduction of the aryloxy moiety is accomplished by S^Ar displacement of an aryl halide or by Cu(OAc)2 catalyzed condensation of substituted benzene boronic acids and phenols as described previously. Oxidation of the dihydrofuran by allylic bromination which spontaneously underwent dehydrobromination afforded 105a. SCHEME 14 DOSAGE AND ADMINISTRATION The compounds of the present invention may be formulated in a wide variety of oral administration dosage forms and carriers. Oral administration can be in the form of tablets, coated tablets, drag^es, hard and soft gelatine capsules, solutions, emulsions, syrups, or suspensions. Compounds of the present invention are efficacious when administered by other routes of administration including continuous (intravenous drip) topical parenteral, intramuscular, intravenous, subcutaneous, transdermal (which may include a penetration enhancement agent), buccal, nasal, inhalation and suppository administration, among other routes of administration. The preferred manner of administration is generally oral using a convenient daily dosing regimen which can be adjusted according to the degree of affliction and the patient's response to the active ingredient A compound or compounds of the present invention, as well as their pharmaceutically useable salts, together with one or more conventional excipients, carriers, or diluents, maybe placed into the form of pharmaceutical compositions and unit dosages. The pharmaceutical compositions and unit dosage forms may be comprised of conventional ingredients in conventional proportions, with or without additional active compounds or principles, and the unit dosage forms may contain any suitable effective amount of the active ingredient commensurate with the intended daily dosage range to be employed. The pharmaceutical compositions may be employed as solids, such as tablets or filled capsules, semisolids, powders, sustained release formulations, or liquids such as solutions, suspensions, emulsions, elixirs, or filled capsules for oral use; or in the form of suppositories for rectal or vaginal administration; or in the form of sterile injectable solutions for parenteral use. A typical preparation will contain from about 5% to about 95% active compound or compounds (w/w). The term "preparation" or "dosage form"is intended to include both solid and liquid formulations of the active compound and one skilled in the art will appreciate that an active ingredient can exist in different preparations depending on the target organ or tissue and on the desired dose and pharmacokinetic parameters. The term "excipient" as used herein refers to a compound that is useful in preparing a pharmaceutical composition, generally safe, non-toxic and neither biologically nor otherwise undesirable, and includes excipients that are acceptable for veterinary use as well as human pharmaceutical use. The term "excipient" as used herein includes both one and more than one such excipient The phrase "pharmaceutically acceptable salt" of a compound means a salt that is pharmaceutically acceptable and that possesses the desired pharmacological activity of the parent compound. Such salts include: (1) acid addition salts, formed with inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, and the like; or formed with organic acids such as acetic acid, propionic acid, hexanoic acid, cyclopentanepropionic acid, glycolic acid, pyruvic acid, lactic acid, malonic acid, succinic acid, malic acid, maleic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, 3-(4-hydroxybenzoyl)benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, 1,2-ethane-disulfonic acid, 2-hydroxyethanesulfonic acid, benzenesulfonic acid, 4-chlorobenzenesulfonic acid, 2-naphthalenesulfonic acid, 4-toluenesulfonic acid, camphorsulfonic acid, 4-methylbicyclo[2.2.2] -oct-2-ene-l-carboxylic acid, glucoheptonic acid, 3-phenylpropionic acid, trimethylacetic acid, tertiary butylacetic acid, lauryl sulfuric acid, gluconic acid, glutamic acid, hydroxynaphthoic acid, salicylic acid, stearic acid, muconic acid, and the like; or (2) salts formed when an acidic proton present in the parent compound either is replaced by a metal ion, e.g., an alkali metal ion, an alkaline earth ion, or an aluminum ion; or coordinates with an organic base such as ethanolamine, diethanolamine, triethanolamine, tromethamine, N-methylglucamine, and the like. N-acylsulfonamides have an acidic proton which can be abstracted to form a salt with an organic or inorganic cation. Other ocompounds of the invention have a basic nitrogen which can from acid addition salts. The preferred pharmaceutically acceptable salts are the salts formed from acetic acid, hydrochloric acid, sulphuric acid, methanesulfonic acid, maleic acid, phosphoric acid, tartaric acid, citric acid, sodium, potassium, calcium, zinc, and magnesium. It should be understood that all references to pharmaceutically acceptable salts include solvent addition forms (solvates) or crystal forms (polymorphs) as defined herein, of the same acid addition salt. Solid form preparations include powders, tablets, pills, capsules, cachets, suppositories, and dispersible granules. A solid carrier maybe one or more substances which may also act as diluents, flavoring agents, solubilizers, lubricants, suspending agents, binders, preservatives, tablet disintegrating agents, or an encapsulating material. In powders, the carrier generally is a finely divided solid which is a mixture with the finely divided active component. In tablets, the active component generally is mixed with the carrier having the necessary binding capacity in suitable proportions and compacted in the shape and size desired. Suitable carriers include but are not limited to magnesium carbonate, magnesium stearate, talc, sugar, lactose, pectin, dextrin, starch, gelatin, tragacanth, methylcellulose, sodium carboxymethylceliuiose, a low melting wax, cocoa butter, and the like. Solid form preparations may contain, in addition to the active component, colorants, flavors, stabilizers, buffers, artificial and natural sweeteners, dispersants, thickeners, solubilizing agents, and the like. Liquid formulations also are suitable for oral administration include liquid formulation including emulsions, syrups, elixirs, aqueous solutions, aqueous suspensions. These include solid form preparations which are intended to be converted to liquid form preparations shortly before use. Emulsions may be prepared in solutions, for example, in aqueous propylene glycol solutions or may contain emulsifying agents such as lecithin, sorbitan monooleate, or acacia. Aqueous solutions can be prepared by dissolving the active component in water and adding suitable colorants, flavors, stabilizing, and thickening agents. Aqueous suspensions can be prepared by dispersing the finely divided active component in water with viscous material, such as natural or synthetic gums, resins, methylcellulose, sodium carboxymethylceliuiose, and other well known suspending agents. The compounds of the present invention may be formulated for parenteral administration {e.g.> by injection, for example bolus injection or continuous infusion) and may be presented in unit dose form in ampoules, pre-filled syringes, small volume infusion or in multi-dose containers with an added preservative. The compositions may take such forms as suspensions, solutions, or emulsions in oily or aqueous vehicles, for example solutions in aqueous polyethylene glycol. Examples of oily or nonaqueous carriers, diluents, solvents or vehicles include propylene glycol, polyethylene glycol, vegetable oils {e.g.> olive oil), and injectable organic esters (e.g, ethyl oleate), and may contain formulatory agents such as preserving, wetting, emulsifying or suspending, stabilizing and/or dispersing agents. Alternatively, the active ingredient may be in powder form, obtained by aseptic isolation of sterile solid or by lyophilisation from solution for constitution before use with a suitable vehicle, e.g., sterile, pyrogen-free water. The compounds of the present invention maybe formulated for topical administration to the epidermis as ointments, creams or lotions, or as a transdermal patch. Ointments and creams may, for example, be formulated with an aqueous or oily base with the addition of suitable thickening and/or gelling agents. Lotions may be formulated with an aqueous or oily base and will in general also containing one or more emulsifying agents, stabilizing agents, dispersing agents, suspending agents, thickening agents, or coloring agents. Formulations suitable for topical administration in the mouth include lozenges comprising active agents in a flavored base, usually sucrose and acacia or tragacanth; pastilles comprising the active ingredient in an inert base such as gelatin and glycerin or sucrose and acacia; and mouthwashes comprising the active ingredient in a suitable liquid carrier. The compounds of the present invention maybe formulated for administration as suppositories. A low melting wax, such as a mixture of fatty acid glycerides or cocoa butter is first melted and the active component is dispersed homogeneously, for example, by stirring. The molten homogeneous mixture is then poured into convenient sized molds, allowed to cool, and to solidify. The compounds of the present invention maybe formulated for vaginal administration. Pessaries, tampons, creams, gels, pastes, foams or sprays containing in addition to the active ingredient such carriers as are known in the art to be appropriate. The compounds of the present invention maybe formulated for nasal administration. The solutions or suspensions are applied directly to the nasal cavity by conventional means, for example, with a dropper, pipette or spray. The formulations may be provided in a single or multidose form. In the latter case of a dropper or pipette, this may be achieved by the patient administering an appropriate, predetermined volume of the solution or suspension. In the case of a spray, this maybe achieved for example by means of a metering atomizing spray pump. The compounds of the present invention maybe formulated for aerosol administration, particularly to the respiratory tract and including intranasal administration. The compound will generally have a small particle size for example of the order of five (5) microns or less. Such a particle size may be obtained by means known in the art, for example by micronization. The active ingredient is provided in a pressurized pack with a suitable propellant such as a chlorofluorocarbon (CFC), for example, dichlorodifluoromethane, trichlorofluoromethane, or dichlorotetrafluoroethane, or carbon dioxide or other suitable gas. The aerosol may conveniently also contain a surfactant such as lecithin. The dose of drug may be controlled by a metered valve. Alternatively the active ingredients may be provided in a form of a dry powder, for example a powder mix of the compound in a suitable powder base such as lactose, starch, starch derivatives such as hydroxypropylmethyl cellulose and polyvinylpyrrohdine (PVP). The powder carrier will form a gel in the nasal cavity. The powder composition maybe presented in unit dose form for example in capsules or cartridges of e.g., gelatin or blister packs from which the powder may be administered by means of an inhaler. When desired, formulations can be prepared with enteric coatings adapted for sustained or controlled release administration of the active ingredient- For example, the compounds of the present invention can be formulated in transdermal or subcutaneous drug delivery devices. These delivery systems are advantageous when sustained release of the compound is necessary and when patient compliance with a treatment regimen is crucial. Compounds in transdermal delivery systems are frequently attached to a skin-adhesive solid support The compound of interest can also be combined with a penetration enhancer, e.g., Azone (l-dodecylaza-cycloheptan-2-one). Sustained release delivery systems are inserted subcutaneously into to the subdermal layer by surgery or injection. The subdermal implants encapsulate the compound in a lipid soluble membrane, e.g., silicone rubber, or a biodegradable polymer, e.g., polyactic acid. Suitable formulations along with pharmaceutical carriers, diluents and expcipients are described in Remington: The Science and Practice of Pharmacy 1995, edited by E. W. Martin, Mack Publishing Company, 19th edition, Easton, Pennsylvania. A skilled formulation scientist may modify the formulations within the teachings of the specification to provide numerous formulations for a particular route of administration without rendering the compositions of the present invention unstable or compromising their therapeutic activity. The modification of the present compounds to render them more soluble in water or other vehicle, for example, may be easily accomplished by minor modifications (salt formulation, esterification, etc.), which are well within the ordinary skill in the art. It is also well within the ordinary skill of the art to modify the route of administration and dosage regimen of a particular compound in order to manage the pharmacokinetics of the present compounds for maximum beneficial effect in patients. The term "therapeutically effective amount" as used herein means an amount required to reduce symptoms of the disease in an individual. The dose will be adjusted to the individual requirements in each particular case. That dosage can vary within wide limits depending upon numerous factors such as the severity of the disease to be treated, the age and general health condition of the patient, other medicaments with which the patient is being treated, the route and form of administration and the preferences and experience of the medical practitioner involved. For oral administration, a daily dosage of between about 0.01 and about 100 mg/kg body weight per day should be appropriate in monotherapy and/or in combination therapy. A preferred daily dosage is between about 0.1 and about 500 mg/kg body weight, more preferred 0.1 and about 100 mg/kg body weight and most preferred 1.0 and about 10 mg/kg body weight per day. Thus, for administration to a 70 kg person, the dosage range would be about 7 mg to 0.7 g per day. The daily dosage can be administered as a single dosage or in divided dosages, typically between 1 and 5 dosages per day. Generally, treatment is initiated with smaller dosages -which are less than the optimum dose of the compound. Thereafter, the dosage is increased by small increments until the optimum effect for the individual patient is reached. One of ordinary skill in treating diseases described herein "will be able, without undue experimentation and in reliance on personal knowledge, experience and the disclosures of this application, to ascertain a therapeutically effective amount of the compounds of the present invention for a given disease and patient. In embodiments of the invention, the active compound or a salt can be administered in combination with another antiviral agent, such as a nucleoside reverse transcriptase inhibitor, another nonnucleoside reverse transcriptase inhibitor or HIV protease inhibitor. When the active compound or its derivative or salt are administered in combination with another antiviral agent the activity may be increased over the parent compound. When the treatment is combination therapy, such administration may be concurrent or sequential with respect to that of the nucleoside derivatives. "Concurrent administration" as used herein thus includes administration of the agents at the same time or at different times. Administration of two or more agents at the same time can be achieved by a single formulation containing two or more active ingredients or by substantially simultaneous administration of two or more dosage forms with a single active agent It will be understood that references herein to treatment extend to prophylaxis as well as to the treatment of existing conditions, and that the treatment of animals includes the treatment of humans as well as other animals. Furthermore, treatment of a HIV infection, as used herein, also includes treatment or prophylaxis of a disease or a condition associated with or mediated by HIV infection, or the clinical symptoms thereof. The pharmaceutical preparations are preferably in unit dosage forms. In such form, the preparation is subdivided into unit doses containing appropriate quantities of the active component. The unit dosage form can be a packaged preparation, the package containing discrete quantities of preparation, such as packeted tablets, capsules, and powders in vials or ampoules. Also, the unit dosage form can be a capsule, tablet, cachet, or lozenge itself, or it can be the appropriate number of any of these in packaged form. Claims wherein X1 is selected from the group consisting of -O-, -S -, -CH2-, -C(O)-; R1 and IT are each independently selected from the group consisting of hydrogen, Q-6 alkyl, Q_6haloalkyl, C3-g cycloalkyl, d-6 alkoxy, Q_6 alkylthio, Q.6 alkylsulfinyl, C1-6 sulfonyi, Q-e haloalkoxy, Q.6 haloalkylthio, halogen, amino, alkylamino, dialkylamino, acyiamino, nitro and cyano; or together R1 and R2 are -0-CH=CH-or -O-CH2CH2-; R3 and R4 are independently selected from the group consisting of hydrogen, Q_e alkyl, Ci_6 haloalkyl, Q-6 alkoxy, Q-e haloalkoxy Q-6 alkylthio, Q.6 haloalkylthio, halogen, amino, nitro and cyano; R5 is selected from the group consisting of Q-6 alkyl, Q-6 haloalkyl, Q_s cycloalkyl, aryl or heteroaryl selected from the group consisting of pyridinyi, N-hydroxypyridine, pyrimidinyl, indole, pyrazinyl and pyrrolyl; wherein, said aryl and said heteroaryl are optionally substituted with one to three substituents independently selected from the group consisting of Q.6 alkyl, Q-6 alkenyl, Q.6 alkynyl, C^ haloalkyl, C3-8 cycloalkyl, Q-6 alkoxy, Q-6 alkylthio, Q.6 alkylsulfinyl, Q.6 sulfonyl, Q-6 haloalkoxy, Q.g haloalkylthio, hydroxy, halogen, amino, Q.6 alkylamino, Q-6 dialkylamino, acyiamino, acyl, Q.6 alkoxycarbonyl, carbamoyl, Q-6 N- alkylcarbamoyl, Q-6N,N-dialkylcarbamoyl, alkynol, -OCCH2OH, »OCCH2N(CH3)2S nitro and cyano, said alkyl and said cycloalkyl are optionally substituted with one or two substituents independently selected from the group consisting of alkyl, hydroxy, alkoxy, thiol, alkylthio, halogen, amino, alkylamino, dialkylamino, amino alkyl, alkylaminoalkyl, and dialkylamino; AT is phenyl optionally substituted with 1 to 3 substituents independently selected in each incidence from the group consisting of Q_6 alkyl, Q.g cycloalkyl, Q.3 haloalkyl, Q.g alkoxy, Q-6 haloalkoxy, halogen, cyano, Q_6 alkylthio, Q.6 alkylsulfinyl, Q.6 sulfonyl, amino Ci-e alkylsulfonyl, Q-e haloalkoxy, Ci.6 haloalkylthio, Q-6 acyl, nitro, Q_6 heteroalkyl, Q-6 heteroalkoxy, hydroxyl, 0t2(CH2)pS(O)nNR8R9; -(CH2)pCOORur-X2(CH2)pNHC(0)NHR8R9) X2(CH2)pCONR8R93-S02R13, -NR8aR9a,X2(CH2)pNRuS(0)2NR8R95 -X2(CH2)pNHCOOR10, -X6(CH2)pC00R1°) -X2(CH2)PCN, -OR15 and C(=0)CH2N[(CH2)2]2X4; or, heteroaryl ring selected from the group consisting of pyridinyl, pyrazolyl and triazolyl said heteroaryl ring optionally substituted with one to three substituents selected from the group consisting of Q.6 alkyl, Q^alkoxy, Q-6 alkylthio, halogen, Q_6 aminoacyl cyano and NR8 R9 ; R8 and R9 taken independently, one of R8 and R9 is hydrogen or Q_6 alkyl and the other of R8 and R9 is selected from the group consisting of hydrogen, -C(=0)R14, -C(=0)CHR12NH2j -(CH2)2N[(CH2)2]20, COC02Me, C3-8 cycloalkyl said cycloalkyl optionally substituted with one or two hydroxyl substituents, pyranyl, Ci-6 alkyl and aryl said alkyl and said aryl groups optionally substituted with one or two substituents independently selected from the group consisting of hydroxy, Q.6 alkoxy, thiol, Q_e alkylthio, Q^ alkylsulfinyl, Q-6 sulfonyl, and halogen; or, (ii) R8 and R9 taken together are (CH2)2-X5-(CH2)2or -(CH2)0- optionally substituted with one or two substituents selected from the group consisting of halogen, hydroxyl and NRilaRnb; R8a and R9a taken independently are selected from the group consisting of hydrogen, Q_6 alkyl, C(=0)C02Ru and S02R10, or (ii) taken together are (CH2)rS02, (CH2)2S(0)p(CH2)2; R10 is Q.6 alkyl; Rn is hydrogen or Q.6 alkyl; RUa, Rllb and Rllc are independendy R11; R12 is the side chain of a naturally occurring a-amino acid; R13 is CM alkyl; -(CH2)sC02Ru, -(CH2)2CN, -(CH2)2NH2> -(CH2)uOH; R14 is Cw alkyl, -(CH2)sNHRUaRnb> (CH2)sORu, -CH2CH(OH)CH3> CH2N[(CH2)2]20, -(CH2)2C02Rn, optionally substituted phenyl or pyridinyl; R15 is Q_6 alkyl optionally substituted with one to three hydroxyl groups; X2 is-O- or a bond; X4 is -O- or -NMe-; X5 is-0-,-S(0)n-orNRn; X6 is -O- or -S(0)ns n is an integer from 0 to 2; o is an integer from 4 to 6; p is an integer from 0 to 6; r is an integer from 3 to 4 s is an integer from 1 to 2; u is an integer from 2 to 3; and, hydrates, solvates and salts thereof; for the manufacture of a medicament for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC 2. Use of compounds of formula I according to claim 1 wherein X1 is selected from the group consisting of-O-, -S -, -CH2-, -C(O)-; R andR are each independently selected from the group consisting of hydro gen, Q.6 alkyl, Q_6 haloalkyl, C3-8 cycloalkyl, Q_6 alkoxy, Q_6 alkylthio, Q_6 alkylsulfinyl, C1-6 sulfonyl, Q-6 haloalkoxy, Q.6 haloalkylthio, halogen, amino, alkylamino, dialkjdamino, acylamino, nitro and cyano; or together R and R are -0-CH=CH-or -0-CH2CHr; R3 and R4 are independently selected from the group consisting of hydrogen, Q„6 alkyl, Q-6 haloalkyl, Q-e alkoxy, Q-6 haloalkoxy, Q.$ alkylthio, C\.e haloalkylthio, halogen, amino, nitro and cyano; R5 is selected from the group consisting of Q_e alkyl, Q.6 haloalkyl, C3.8 cycloalkyl, aryl or heteroaryl selected from the group consisting of pyridinyl, N-hydroxypyridine, pyrimidinyl, indole, pyrazinyl and pyrrolyl; wherein, said aryl and said heteroaryl are optionally substituted with one to three substituents independently selected from the group consisting of Q.6 alkyl, C2.6 alkenyl, Q-6 alkynyl, Ci-e haloalkyl, C3.8 cycloalkyl, C\.6 alkoxy, Q.6 alkylthio, Q_6 alkylsulfinyl, Q.6 sulfonyl, Q.6 haloalkoxy, Q-6 haloalkylthio, hydroxy, halogen, amino, Q.6 alkylamino, Q-6 dialkylamino, acylamino, acyl, Q_6 alkoxycarbonyl, carbamoyl, Ci-6 N- alkylcarbamoyl, Q_6 N,N-dialkylcarbarnoyl, nitro and cyano, said alkyl and said cycloalkyl are optionally substituted with one or two substituents independently selected from the group consisting of alkyl, hydroxy, alkoxy, thiol, alkylthio, halogen, amino, alkylamino, dialkylamino, amino alkyl, aflcylaminoalkyl, and dialkylamino; Ar is phenyl optionally substituted with 1 to 3 substituents independently selected in each incidence from the group consisting of Q-6 alkyl, Q.8 cycloalkyl, Q_3 haloalkyl, Q-6 alkoxy, Q-6 haloalkoxy, halogen, cyano, Q_e alkylthio, Q_6 alkylsulfinyl, Q-6 sulfonyl, amino Q-6 alkylsulfonyl, Q.6 haloalkoxy, Q_6 haloalkylthio, Q-e acyl, nitro, Q.6 heteroalkyl, Q_6 heteroalkoxy, hydroxyl, -X2(CH2)pS(0)nNR8R9; -(CH2)pCOOR1^--X2(CH2)pNHC(0)NHR8R^X2(CH2)pCONR8R9,-S02R13, -NR^R9*, X2(CH2)pNRuS(0)2NR8R9, -X2(CH2)pNHCOOR10, -X6(CH2)pCOOR10, -X2(CH2)PCN, -OR15 and C(=0)CH2N[(CH2)2]2X4; or, heteroaryl ring selected from the group consisting of pyridinyl, pyrazolyl and triazolyl said heteroaryl ring optionally substituted with one to three substituents selected from the group consisting of Q.g alkyl, Q_e alkoxy, Q-6 alkylthio, halogen, Q.6 aminoacyl and NR8bR9b; R8 and R9 taken independently, one of R8 and R9 is hydrogen or Q.6 alkyl and the other of R8 and R9 is selected from the group consisting of hydrogen, -C(=0)R14, -C(=0)CHR12NH2) «(CH2)2N[(CH2)2]20, C0C02Me, Q.8 cycloalkyl said cycloalkyl optionally substituted with one or two hydroxyl substituents, pyranyl, Q-6 alkyl and aryl said alkyl and said aryl groups optionally substituted with one or two substituents independently selected from the group consisting of hydroxy, Q-6 alkoxy, thiol, Q.6 alkylthio, Q-6 alkylsulfinyl, Q-6 sulfonyl, and halogen; or, (ii) R8 and R9 taken together are (CH2)2-X5-(CH2)2 or -(CH2)0- optionally substituted with one or two substituents selected from the group consisting of halogen, hydroxyl and NRllaRllb; R8a and R9a taken independently are selected from the group consisting of hydrogen, Q_6 alkyl, C(=0)C02Rn and S02R10, or (ii) taken together are (CH2)rS02, (CH2)2S(0)p(CH2)2; R10 is Ci-6 alkyl; R11 is hydrogen or Q-6 alkyl; Rlla, Rllb and Rllc are independently Ru; R " is the side chain of a naturally occurring a-amino acid; R13 is CM alkyl; -(CH2)sC02Ru, -(CH2)2CN, -(CH2)2NH2, -(CH2)uOH; R14 is On alkyl, -(CH2)sNHRUaRub, (CH2)sORn, -CH2CH(OH)CH3, CH2N[(CH2)2]20, -(CH2)2C02Rn, optionally substituted phenyl or pyridinyl; R15 is Ci-e alkyl optionally substituted with one to three hydroxyl groups; X2 is -O- or a bond; X4 is -O- or -NMe-; X5 is-0-,-S(0)n-orNRn; X6 is O- or -S(0)us n is an integer from 0 to 2; o is an integer from 4 to 6; p is an integer from 0 to 6; r is an integer from 3 to 4 s is an integer from 1 to 2; u is an integer from 2 to 3; and, hydrates, solvates and salts thereof; for the manufacture of a medicament for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. 3. Use of compounds of formula I according to claim 1 or 2, wherein X1 is selected from the group consisting of -O-, -S -, -CH2-, -C(O)-; RlandR2 are each independently selected from the group consisting of hydrogen, Q-6 alkyl, Q-6 alkoxy and halogen; or together R and R" are -0-CH=CH- or -0-CH2CHr; R3 and R4 are independently selected from the group consisting of hydrogen and halogen; R is aryl or heteroaryl selected from the group consisting of pyridinyl, N-hydroxypyridine, pyrimidinyi, indole, pyrazinyl and pyrrolyl; wherein, said aryl and said heteroaryl are unsubstituted or substituted with one to three substituents independently selected from the group consisting of Q_6 alkyl, Q_6 haloalkyl, Ci_6 haloalkoxy, d.6 haloalkoxy, halogen, -OCCH2OH, -OCCH2N(CH3)2 and cyano. Ar is phenyl optionally substituted with 1 to 3 substituents independently selected from the group consisting of Q_6 alkyl, C3-8 cycloalkyl, C1.3 haloalkyl, Q.6 alkoxy, halogen, cyano, Q-e alkylsulfinyl, Q_6 sulfonyl, amino Q.6 alkylsulfonyl, Q.6 haloalkoxy, Q_6 haloalkylthio, Q_6 acyl, nitro, Q.6 heteroalkyl, Q.6 heteroalkoxy, hydroxyl, -X2(CH2)pS(0)nNR8R9; -(CH2)PCOORn, -X2(CH2)pNHC(0)NHR8R9, X2(CH2)pCONR8R9,-S02R13, -NR8aR9a, -X2(CH2)pNRnS(0)2NR8R9, -X2(CH2)pNHCOOR10, -X6(CH2)pCOOR10, -X2(CH2)PCN, -OR15 and C(=0)CH2N[(CH2)2]2X4; or, heteroaryl ring selected from the group consisting of pyridinyl, pyrazolyl and triazolyl said heteroaryl ring optionally substituted with one to three substituents selected from the group consisting of Q.6 alkyl, Q-6 alkoxy, Q.6 alkylthio, halogen, Q.6 aminoacyl, cyano and NR84l9 ; R8 and R9 taken independently, one of R8 and R9 is hydrogen or Q-6 alkyl and the other of R8 and R9 is selected from the group consisting of hydrogen, -C(=0)R14, -C(=0)CHR12NH2, -(CH2)2N[(CH2)2]20, COC02Me, CM cycloalkyl said cycloalkyl optionally substituted with one or two hydroxyl substituents, pyranyl, Q.6 alkyl and aryl said alkyl and said aryl groups optionally substituted with one or two substituents independently selected from the group consisting of hydroxy, Q.6 alkoxy, thiol, Q-6 alkylthio, Q.6 alkylsulfinyl, Q.6 sulfonyl, and halogen; or, (ii) R8 and R9 taken together are (CH2)2-X5-(CH2)2 or -(CH2)0- optionally substituted with one or two substituents selected from the group consisting of halogen, hydroxyl and NRUaRub; R8a and R9a taken independently are selected from the group consisting of hydrogen, Q-6 alkyl, C(=0)C02R11 and SO2R!0, or (ii) taken together are (CH2)rS02, (CH2)2S(0)P(CH2)2; R10 is Q.6 alkyl; R11 is hydrogen or Q-6 alkyl; Rlla, Rllb and Rllc are independently R11; R " is the side chain of a naturally occurring a-amino acid; R13 is Ci.6 alkyl; -(CH2)sC02R12, -(CH2)2CN, -(CH2)2NH2, -(CH2)uOH; R14 is d.6 alkyl, -(CH2)sNHRIiaRilb, (CH2)sORn, -CH2CH(OH)CH3, CH2N[(CH2)2]20, -(CH2)2C02Ru, optionally substituted phenyl or pyridinyl; R15 is Q-6 alkyl optionally substituted with one to three hydroxyl groups; X2 is -O- or a bond; X4 is -O- or -NMe-; X5 is-0-,-S(0)n-orNRn; X6 isO-or-S(0)n-; n is an integer from 0 to 2; o is an integer from 4 to 6; p is an integer from 0 to 6; r is an integer from 3 to 4 s is an integer from 1 to 2; u is an integer from 2 to 3; and, hydrates, solvates and salts thereof, for the manufacture of a medicament for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. 4. Use of compounds of formula I according to 3, wherein X1 is selected from the group consisting of -O, -S -, -CH2-, -C(O)-; are each independently selected from the group consisting of hydrogen, methyl, ethyl, i-propyl, methoxy, chloro and bromo; or together R1 and R2 are -0-CH=CH- or -0-CH2CH2-; R3 and R4 are independently selected from the group consisting of hydrogen and fluoro; R5 is phenyl, wherein said phenyl is unsubstituted or substituted with one to three substituents independently selected from the group consisting of methyl, ethyl, CHF2, CF3, -CF2CH3> -OCHF2, chloro, bromo, fluoro, -OCCH2OH, -OCCH2N(CH3)2 and cyano. or pyridinyl, wherein said pyridinyl is unsubstituted or substituted with one to three substituents independently selected from the group consisting of methyl and cyano. Ar is phenyl, wherein said phenyl is unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of methyl, ethyl, i-propyl, ^, ° , ^^>, ° , ' , ^^*°,-CF3, methoxy, chloro, fluoro, cyano, hydroxyl,-SCH3, -S02NH2, -S02NHCH3, -S02NCH3CH2CH2OH, -S02NHCH2CHCH30H, -S02NHCH2CH2CH2OH,-S02NHCH2CH2( ^-°),-S02( L-s),-S02N(CH3)2, -S02( 0),-S02( 0),-S02(- -S02( k-s),- S02NHCOCH2CH3, -S02NHCOCH2CH2CH3, -S02NHCOCH(NH2)CH(CH3)2, -SO2NHC0CH2( -S02NCH3COCH2CH2CH3,-S02NHCOCH2CH2CH2CH3, -S02NHCOCH2CH(CH3)2,-S02NHCOCH2CH(CH2CH3)2, -SO2NHCOCH2CH2CH(CH3)2,-S02NHC0CH2CH2NH2, -S02NCH3COCH2CH2NH2,-S02NHCOCH(NH2)CH(CH3)2, -S02NHCOCH2OCH3, -S02NHCO(V^), -S02NH( ^°), -S02NHCOCH(i-propyl)NH2,-S02NHCH2CH2SCH3, -S02NCH3COCH2CH3, -S02NCH3COCH2OCH3, -S02NCH3COCH2CH2OCH3> -S02NHCOCH2OCH3, -S02NHCOCH2OH, -S02NHCOCH2CH2COOH, -S02CH2CH2NH2, -S02CH2COOH, -S02CH2CH2COOH, -S02CH3, -S02CH2CH2CN, -S02CH2CH2CH2OH, -0(CH2)3S02NH2> -OCH2COOH, -OCH2COOCH3, -OCH2CN, -OCH2CHOHCH2OH, -OCH2CH2CHOHCH2OH, -SCH2COOCH3> -COOCH3, -COOH, -COCH2( ^^), -COCH2( ^°), -CH2COOCH3, -CH2COOH, -CH2CH2COOCH3, CH2CH2CH2COOCH3, -N(CH3)2, -NHCOCOOCH2CH3, -NHS02CH3 and -NCH3S02CH3; or heteroaryi ring selected from the group consisting of pyridinyl, pyrazolyl and triazolyl said heteroaryi is unsubstituted or substituted with one or two substituents selected from the group consisting of methyl, methoxy, -SCH3> and -NHCOOCH3; RUc is hydrogen or methyl; and Hydrates, solvates and salts thereof. 5. Use of compound of formula I according to claim 1, which compound is 2-[4-CMoro-3-(3-cUorO"5-cyano-phenoxyr)-phenyl]-N-(4-sulfamoyl-phenyl)«acetamide; 2-[4-Chloro-3-(3,5-dicyano-phenoxy)-phenyl]-N-(4-sulfamoyl-phenyl)-acetamide; 2-[3-(2-Bromo-5-chlorO"phenoxy)-4-chloro-phenyl]«N-[2-methyl-4-(3-sulfamoyl- propoxy)-phenyl] -acetamide; 2-[3-(2-Bromo-5-chloro-phenox7)-4-chloro-phenyl]-N-(4-sulfamoyl-phenyl)- acetamide; 2-[4-CHoro-3-(3,5-dicyano-phenoxy)-phenyl]-N-(2-chloro-phenyl)-acetamide; 2-[4-CHoro-3-(3,5-dicyano-phenox7)-phenyl]-N-(4-dimethylamino-phenyl)-acetamide; 2-[3-(2-CUoro-5-cyano«phenoxy)-4-ethyl-2-fluoro-phenyl]-N«(4-sulfamoyl-phenyl)- acetamide; 2-[4-Chloro-3-(2,5-dicyano-phenoxy)*2-fluoro-phenyl]"N-(4-sulfamoyi-phenyl)- acetamide; 2-[4-Chloro-3-(3,5-dicyano-phenoxy)*2-fluoro-phenyl]-N-(4-sulfamoyl'phenyl)» acetamide; 2-[4-Chloro-2-fluoro-3-(2,3>5-trichloro-phenoxy)-phenyl]-N-(4-s\ilfamoyl-phenyl)- acetamide; 2-[3-(3-Cyano-5-fluoro-phenoxy)«4-methyl-phenyl]-N«(4-sxilfamoyl"phenyl)" acetamide; N-(2-Chloro-phenyl)-2-[3»(3-cyano-5-fluoro-phenoxy)-4-methyl«phenyl]-acetamide; 2-[4-ChlorO"3-(3-cyano-5-difluoromethyl-phenoxy)-2-fluoro-phenyl]-N-(4-sulfamoyl- phenyl)-acetamide; 2-[4-Chloro-3-(3-q^ano-5-difluoromethyl-phenoxy)-2«fluoro-phenyl]-N-(2"chloro- phenyl)-acetamide; 2-[3-(2-Bromo-5-cHoro-phenoxy)-4-ethyl-phenyl]-N-(4-sulfamoyl-phenyl)-acetarnide; 2-[3-(2-Bromo-5-chloro-phenoxy)-4«ethyl--phenyl]-N"(2-chloro-phenyl)-acetamide; 2-[3-(5<:hloro-2-cyano-phenoxy> 2-[3-(5-Chloro-2-q^ano-phenoxy)-4-ethyl-phenyl]-N-(2-chloro-phenyl)-acetamid 2-[3-(2,5-Dichloro-phenoxy)-4-ethyl-phenyl]-N-(4-sulfamoyl-phenyl)-acetamide; 2-[3-(2?6«DicUoro-phenoxy)-4-ethyl-phenyI]-N-(4-sulfamoyl-phenyl)"acetamide; N-(2-CUoro-phenyl)-2-[3"(2,5-dichloro-phenox7)-4-eihyl-phenyl]-acetamide; 2-[3-(3-Bromo-5-cMoro-pheno;xy)-4^ N-(2-CUoro-phenyl)-2-[3"(236-dicUoro-phenoxy)-4-ethyl-phenyl]-acetamide; 2-[3-(3-Bromo-5-cUoro-phenoxy)-4-et^^ N-(2-Chloro-phenyl)-2- [3-(3>5-dicyano-phenoxy)-4-etliyl-phenyl] -acetamide; 2-[3-(2-Bromo-5-chloro-phenoxy)-4-isopropyl-phenyl]-N-(4-siilfamoyl-phenyl)« acetamide; 2-[3-(2-Bromo-5-chloro-plienoxy)«4-isopropyl-phenyl]-N-(2-chloro«phenyl)- acetamide; 2-[4-Chloro-3-(3,5-diq^ano-phenoxy)-2-fluoro-phenyl]-N-(2-chloro-phenyl)- acetamide; 2-[4-CUoro-3-(3>5-diqrano»phenoxy)-phenyl]-N-[2-methyl»4-(3-sulfamoyl«propoxy)^ phenyl] -acetamide; 2-[3-(2-Bromo-5-cMoro-phenoxy)-4-methyl-phenyl]-N-(4-sulfamoyl-phenyl)- acetamide; 2-[3-(2-Bromo-5-chloro«phenoxy)-4-methyl-phenyI]-N-(2-methyl-4-sulfamoyl- phenyl)-acetamide; 2-[4-Chloro-3-(3>5-di(^ano-phenoxy)-2-fluoro-phenyl]-N-(2-methyI-4-sidfamoyl- phenyl)-acetamide; 2-[3-(2-Bromo-5-cUoro-phenoxy)-4»meliiyl-phenyl]-N-(2-chloro-phenyl)-acetamide; N-(2-Chloro-phenyl)-2-[3-(3>5»dicyano-phenoxy)-4-methyl-phenyl]-acetamide; 2-[3-(3-Bromo-2>5-dichloro»phenoxy)-4-ethyI-phenyl]-N-(4-siilfamoyl-phenyl)- acetamide; 2-[3-(3-Bromo-2,5-dichloro»phenoxy)-4-ethyl-phenyl]-N-(2-me1iyl-4-sulfemoyl- phenyl)-acetamide; 2-[3-(3-Bromo-2,5-dicUoro-phenoxy)-4-ethyl-phenyl]-N-(2-cUoro-phenyI)-acetamide; N-(2-Chloro-phenyl)-2-[3-(3>5-dibromo-2-chloro-phenoxy)-4-ethyl-phenyl] -acetamide; 2-[3-(5-Bromo-2-cUoro-3-fluoro-phenoxy)-4-ethyi-phenyl]-N-(4-sulfamoyl-phenyl)- acetamide; 2-[3-(5-Bromo-2-chloro-3-fluoro-pheno^ phenyl)-acetamide; 2-[3-(5-Bromo-2n:Uoro-3-fluoro-phenoxy)-4-ethyl-phenyl]-N-(2-chloro-pheiiyl)- acetamide; 2-[4-CUoro-3-(3-cUoro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-metiiyl-4-siilfamoyl- phenyl)-acetamide; 2-[3-(3,5-Dicyano-phenoxy)-4-methyI-phenyI]-N-(2-me1iyl-4-siilfamoyl-phenyl)- acetamide; N-(2-CUoro-4-sulfamoyl-phenyl)-2-[3-(3,5-dicyano-phenoxy)-4-mettyl-phenyl]- acetarnide; 2-[3-(3-CUoro-5-cyano-phenoxy)-4-eliiyl-phenyl]-N-(4-sulfamoyl-phenyl)-acetaimde; 2-[3-(3-CUoro-5-cyano-phenoxy)-4-e^ acetamide; 2- [3 - (3-Chloro- 5-cyano-phenoxy) -4-ethyl-phenyl] -N- (2-chloro-4-sulfamoyl-phenyI)- acetamide; 2-[3-(3-CMoro-5-cyano-phenoxy)-4-etiiyl-phen^^ acetamide; 2- [3- (2-Chloro-5-cyrano-3-fluoro-phenoxy)-4-ethyl-phenyl] -N~(4-sulfamoyl-phenyl)- acetamide; 2-[3-(2-Chloro-5-cyano-3-fluoro-phenoxy)-4-eliyl-phenyl]-N-(2-methyl-4-sulfamoyl- phenyl)-acetamide; 2-[4-CUoro-3-(3-cUoro-5-q^ano-phenoxy)-2-fluoro-phenyl]-N-(2-methyi-4- propionylsulfamoyl-phenyl)-acetamide; 2-[3-(2-CUoro-3,5-diq^ano-phenoxy)-4-ethyl-phenyl]-N-(4-sulfamoyl-phenyl)- acetamide; 2-[3-(2-CUoro-3,5-diqrano-phenoxy)-4-etiiyl-phenyl]-N-(2-metiiyl-4-sdfainoyl- phenyl)-acetamide; 2-[3-(2-CUoro-3>5-dicyano-phenoxy)-4-ethyl-phenyl]-N-(2-chloro-4»siilfamoyl- phenyl)-acetamide; 2-[4-Chloro-3-(4-cyano-2,6-dimethyl-pheno^ acetamide; 2-[4-CUoro-3-(4-cyano-2,6-dimeiiiyl-ph^^ phenyl)-acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)-4-methoxy-phenyl]--N-(4-sulfamoyl-phenyl)- acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)-4-ethyl-phenyl]-N-(2-chloro»phenyl)-acetamide; 2-[3-(2-Chloro-5-cyano-3-fluoro-phenoxy)-4-etiiyl-phenyl]-N-(2-chloro-phenyl)- acetamide; 2-[3-(2-CUoro-3,5-dicyanO"phenoxy)-4-elhyl-phenyl]-N-(2-chloro-phenyl)-aceU 2-[3«(3-Chloro-5-cyano-phenoxy)-4-methoxy-phenyl]-N-(2-chloro-phenyl)-acetamide; 2-[3-(2-CUoro-5-cyano-phenoxy)-4-me&^ 2-[4-Bromo-3-(3-chloro-5-cyano-phenox7)-2-fluoro-phenyl]»N-(2-chloro-4- propionylsulfamoyl-phenyl)-acetamide; sodium salt; 2-[3-(3-Chloro-5-cyano-phenox7)-4-methoxy-phenyl]*N-(2-chloro-4-sulfemoyl- phenyi)-acetamide; 2-[3-(2-ChlorO"5-cyano-phenoxy)-4-methoxy-phenyl]«N-(4-sulfamoyl-phenyl)- acetamide; 2-[3-(2-Chloro-5-cyano-phenoxy)-4-methoxy-phenyl]-N-(2-methyl-4-stdfamoyl- phenyl)-acetamide; 2-[3-(2-Chloro-5-cyano-phenoxy)-4-methoxy--phenyl]-N-(2-chloro-4-sulfamoyl- phenyl)-acetamide; 2-[4-CUoro-3-(4-q^ano-2,6-dimetii7l-phenoxy')-phenyl]-N-(2-cWoro-phenyl)-acetamide; 2-[4-CUoro-3-(3,5-diq^ano-phenoxy)-phenyl]-N-(4-metiiylsiilfamoyl-pheiiyl)- acetamide; 2-[4-CMoro-3-(3,5-dicyano-phenoxy)-phenyl]-^ acetamide; 2-[4-CMoro-3-(33-dicyano-phenoxy)-phenyl]-N-[4-(piperidine-l-sulfonyl)-phenyl]- acetamide; 2-[4-Chloro-3-(3,5-dicyano-phenoxy)-phenyl]^ acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)-4-methoxy-phenyl]-N-(2-methyl-4-sulfamoyl- phenyl)-acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)-2-fluoro-4-methyl-phen}d]-N-(2-methyl-4- sulfamoyl-phenyl)-acetamide; 2-[4-CUoro-3-(3-cyano-5-difluoromethyl-phenoxy)-2-fluoro-phenyl]-N-(2-methyl-4- sulfamoyl-phenyl) -acetamide; 2-[4-CUoro-3-(3,5-dicyano-phenoxy)-phenyl]-N-(2-cMoro-4-methanesulfonyl-pheny^ acetamide; N-[4-((S)-2-Amino-3-methyl-but^ chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-acetamide; compound with hydrochloric acid; 2-[4-CUoro-3-(3,5-dicyano-phenoxy)-phenyl]-N-(4-cyanomethoxy-phenyI)-acetamide; 2-[4-Chloro-3-(3,5-dicyano-phenoxy)-phenyl]-N-(4-methanesulfonyl-phenyl)- acetamide; 3-Chloro-4-{2-[4-chloro-3-(3>5-dicyano-phenoxy)-phenyl]-acetylamino}-benzoicacid methyl ester; 2-[4-Chloro-3-(3,5-dicyano-phenoxy)-phenyI]-N-{4-[(2-hydroxy-ethyl)-methyl- sulfamoyl] -phenylj-acetamide; 2-[4-CHoro-3-(3,5-dicyano-phenoxy)-^^ phenyl] -acetamide; 2-[3-(3-CUoro-5-cyano-phenoxy-)-2-fluoro-4-methyl-phenyl]-N-(2-chloro-4-sulfamoyl- phenyl) -acetamide; N-(2-Chloro-4-sxilfamoyl-phenyl)-2-[3-(3-cyano-5-difluoromethyl-phenoxy)-2-fluoro- 4-methyl-phenyl] -acetamide; 2-[3-(3-Cyano-5-difluoromethyl-phenoxy)-2-fluoro-4-methyl-phenyl]-N-(2-methyl-4- snlfamoyI-phenyl)-acetamide; N-(2-Chloro-phenyl)-2-[3-(3-cyano-5-difluoromethyl-phenoxy)-2-fluoro-4-methyl- phenyl] -acetamide; 2-[4-Chloro-3-(3-chloro-5-q^ano-phenoxy)-2-fluoro-phenyl]-N-{2-methyl-4-[(pyridine-3-carbonyl)-siilfamoyI]-phenyl}-acetamide; compound with hydrochloric acid; 2-[4-CUoro-3-(3-cyano«5-1xifluoromethyl-phenoxy)-phenyl]-N-(4-sulfamoyl-phenyl)'-acetamide; 2-[4-Chloro-3-(3-(7ano-5-1rifluoromet^^ phenyl)-acetamide; 2-[4«CUoro-3«(3-cyanO"5-1xifluoromethyi-phenoxy)-phenyl]-N-(2-cUoro-4-sulfamoyl-phenyl)-acetamide; 2-[3«(3-Cyano-5-difluoromethyl-phenoxy)-4-ethyl-phenyl]-N-(4-sxilfamoyl-phenyl)-acetamide; 2-[3»(3-Cyano-5-difluoromethyl-phenoxy)-4-methoxy-phenyl]-N-(4-sulfamoyl-phenyl)-acetamide; 2-[3-(3-Cyano-5-difluoromethyl-phenoxy)^-methoxy-phenyl]-N-(2-methyl-4- sulfamoyl-phenyi)-acetamide; N-(2-CWoro-4-sulfamoyl-phenyl)-2-[3-(3-cyano-5-difluoromethyi-phenoxy)-4- methoxy-phenyl] -acetamide; 2-{4-Chloro-3-[3-cyano-5-(l,l-difluoro-ethyl)-phenoxy]-2-fluoro-phenyl}-N-(4- sulfamoyl-phenyl)-acetamide; 2-{4-Chloro-3»[3-cyanO"5-(l,l-difluoro-ethyl)-phenoxy]-2-fluoro-phenyl}-N-(2- methyl-4-sulfamoyl-phenyl) -acetamide; 2-{4«CUoro-3-[3-cyano«5-(l)l-difluoro-ethyl)-phenoxy]-2-fluoro-phenyl}-N-(2-chloro- 4-sulfamoyl-phenyl)-acetamide; 2-[4»Chloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-chloro-phenyl)- acetamide; 2-[4-CUoro-3-(3-cUoro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-[2-methyl-4-(methyl- propionyl-sulfamoyl)-phenyl]-acetamide; 2-[4-Chloro-3-(3-chloro-5-cyano-phenoxy)«2-fluoro-phenyl]-N-(2-chloro-4-sulfamoyl- phenyl)-acetamide; 2-[3--(3-Cyano-5-difluoromethyl-phenoxy)-4-ethyl-phenyl]-N-(2-methyl-4-sulfamoyl- phenyl)-acetamide; 2-[3-(2-Chloro-5--cyano-phenoxy)-5-methoxy-phenyl]-N-(4-siilfamoyl-phenyl)- acetamide; 2-[3"(2-Chloro-5-cyano-phenoxy)-5-methoxy-phenyl]-N-(2-methyl-4-sulfamoyl- phenyl)-acetamide; 2-[4>5-Dibromo-3-(3-cyano-5-difluoromethyl-phenoxy)-2-fluoro-phenyl]-N-(2-metihyl- 4-sulfamoyl-phenyl)-acetamide; 2-[3"(2-CUoro-5-cyano-phenoxy)-5-e&yl-phenyl]-N-(4-sulfamoyl-phenyl)-acetamide; 2-[3-(2-CUoro-5-cyano-phenoxy)-5-ethyl-phenyl]-N-(2-methyl-4-sulfamoyl-phenyl)- acetamide; 2-[3-(2-CUoro-5-cyano-phenoxy)-5-e acetamide; 2-[4-Chloro-3-(3-chloro-5-q^ano-phenoxy)-2-fluoro--phenyl]-N-(2-methyl-4-methylsulfamoyl-phenyi)-acetamide; 2-[4-Bromo-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-chloro-4-stilfamoyl-phenyl)-acetamide; 3-CUoro-4-{2-[3-(3-cyano-5-difluorometfcyl-phenoxy)-2-fluoro-4-methyl-phenyl]-acetylamino} -benzoic acid; 2-[4-Chloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-chloro-phenyl)-N- methyl-acetamide; N-(2-CHoro-4-methanesulfonyl-phenyl)-2-[3-(3-^ fluoro-4-methyl-phenyl] -acetamide; 2-[3-(2-CUoro-5-cyano-phenoxy)-5-me&^ phenyi)-acetamide; 2-[4,5-Dibromo-3-(3-cyano-5-di£luoromethyl-phenoxy)-2-fluoro-phenyl]-N-(4- sulfamoyi-phenyl)-acetamide; 2-[ 3 - (3-CUoro-5-cyano-pheno:xy)-4-^ sulfonyl)-phenyl] -acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)-4-methyl-phenyl]-N-[2-methyl-4-(4-methyl- piperazine-l-sulfonyi)-phenyl]-acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)-4-metiiyl-phenyl]-N-[2-methyl-4-(thiomorpholine- 4-sulfonyl)-phenyl] -acetamide; 2- [3-(3-Chloro-5-cyano-phenoxy)-4-methyl-phenyi] -N- [2-methyl-4-(2-morpholin-4-yl- ethylsulfamoyl)-phenyl] -acetamide; 2-[3-(3-Cldoro-5-cyano-phenoxy)-4-methyl-phenyl]-N-[4-(3-hydroxy- propyisulfamoyl)-2-methyl-phenyl]-acetamide; 2-[4-CUoro-3-(3-cyano-5-1xifluoromethyl-phenoxy)-2-fluoro-phenyl]-N-(2-methyl-4- sulfamoyl-phenyl)-acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)-4-methyl-phenyl]-N-[4-(4-hydroxy- cyclohexylsulfamoyl)-2-methyl-phenyl]-acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)-4-methyl-phenyl]-N-(2-methyl-4-siolfamoyl-phenyl)- acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)-4-methy^ acetamide; 3-(4-{2-[3-(3-CUoro-5-cyano-phenoxy)-4-me^ benzenesulfonyl)-propionic acid; 2-[4-Chloro«3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-chloro-4- propionylsulfamoyl-phenyl)-acetamide; sodium salt; N-[4-((S)-2-Amino-3-methyl-but^ chloro-5-q?rano-phenoxy)-2-fluoro-phenyi]-acetainide; sodium salt; 2- [3-( 3-Chloro- 5-cyano-phenoxy)-4-methyl-phenyl] -N- [2-me1&yl-4-(teixahydro-pyran- 4-ylsulfamoyl)-phenyl] -acetarnide; 2-[3-(3»Chloro-5-cyano-phenoxy)-4-methyl-phenyl]-N'[4-(2-hydroxy- propylsulfamoyl)-2-me&yl-phenyl]-acetarnide; 2-[3-(3-Chloro-5-cyano-phenoxy)-4~metliy^ ethylsulfamoyl)-phenyi] -acetarnide; 2-[3-(3-Chloro-5-cyano-phenoxy)-4-methyl-phenyl]-N-[2-methyl-4-(3-m propylsulfamoyl)-phenyl] -acetarnide; 2-[3-(3-Chloro-5-cyano-phenoxy)-5-methoxy-phenyl]-N"(4-sulfamoyl-plienyl)- acetamide; 2- [ 3 -(3-Chloro- 5-cyano-phenoxy) - 5-methoxy-plienyl]-N-(2-methyl-4'Sulfamoyl- phenyl)-acetamide; N-(2-CMoro-4-sulfamoyl-phenyl)-2-[43-dfc^ phenoxy)-2-fluoro-phenyl] -acetarnide; 2-[4-Chloro-3-(4-cyano-2,6-dimethyl-pheno:xyV^^ phenyl)-acetamide; 2-[3-(3-CUoro-5-cyano-phenoxy)-5-methoxy-plienyl]-N-(2-chloro-4-sijlfamoyl- phenyi)-acetamide; 2-[3-(3-CUoro-5-cyano-phenoxy)-4-meltyl-phenyl]-N-[4-(2-cyano-ethanesulfonyl)-2- methyl-phenyl] -acetarnide; N-(4~Butyrylsulfamoyl-2-chloro-ph^ fluorophenyl] -acetarnide; sodium salt; N- [4-(Butyryl-methyl-srifamoyl)-2-cMoro-phenyl] -2- [4-chloro-3- (3-chloro-5-cyano~ phenoxy)-2-fluoro-phenyl]-acetamide; N-(2-CMoro-4-sulfamoyl-phenyl)-2-[^ phenyl] -acetarnide; 2.[3-(3-Chloro-5-cyano-phenoxy)-5-methyl-phenyl]-N-(4-sulfamoyl-phenyl)- acetamide; 2-[3-(3-CUoro-5"cyano-phenoxy)-5-meAyl-phenyl]-N-(2-methyl-4-sulfamoyl-phenyl)- acetamide; 2-[3-(3-CMoro-5- acetarnide; 2-[7.(3-Cyano-phenoxy)-benzofuran-5-yl]-N-(4-sulfamoyl-phenyl)-acetamide; 2-[7-(3-Cyano-phenoxy)-benzofuran-5-yl]-N-(2-meliyl-4-sulfamoyl-phenyl)- acetamide; 2-[3-(2-Chloro-5-cyano-phenoxy)-5-methyl-phenyl]-N-(4-sulfamoyl-phenyl)- acetamide; 2-[3-(2-Chloro-5-cyano-phenoxy)-5-m acetamide; 2-[3-(2-Chloro~5-cyano-phenoxy)-5-methy^^ acetamide; N-(2-CUoro-4-sdfamoyl-phenyl)-2-[7-(33-dichloro-phenox7)-benzofuran-5-yl]-acetamide; 2-[3-(3-CUoro-5-cyano-phenoxy)-4-methyl-phenyl]-N-[4-((S)-2>3-dihydroxy-propoxy)-2-methyl-phenyl] -acetamide; 2- [3-(3-Chloro-5-cyano-phenoxy)-4-methyl-phenyl] -N- [4-( (R)-3,4-dihydroxy-butoxy)- 2-methyl-phenyl] -acetamide; (4-{2-[3-(3-CWoro-5-cyano-phenoxy)-4-met^ benzenesulfonyl)-acetic acid; N-[4-(3-Amino-propionylsulfe^ cyano-phenoxy)-2-fluoro-phenyl] -acetamide; compound with hydrochloric acid; N"[4-(2-Amino-ethanesuifonyl)-2-metiiyl-phenyl]-2-[3-(3-chloro-5-cyano-phenoxy)-4- methyl-phenyl] -acetamide; 2-[4-Chloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-[2-chloro-4-(2- methoxy-acetylsulfamoyl)-phenyl]-acetamide; sodium salt; 2-[4-Chloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N"[2-chloro-4-(2- hydxoxy-acetylsulfamoyl)-phenyl]-acetamide; sodium salt; 2-[3-(3-Chloro-5-cyano-phenoxy)-4-methyl-phenyl]-N-[4-(3-hydroxy-propane-l- sulfonyl)-2-methyl-phenyl]-acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)-4-methyl-phenyl]-N-[4-(l,l-dioxo-lX6- [ 1,2] thiazinan-2-yl)-2-methyl-phenyl] -acetamide; 2-[3-(3-CMoro-5-c^ano-phenoxy)-4-meAyl-phenyl]-N-{2-methyl-4-[2-(4-methyl- piperazin-1 -yl)-acetyl] -phenyl} - acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)-4-methyl-phenyl]-N-[2-methyl-4-(l-oxo-lX4- thiomorpholin-4-yi)-phenyl} -acetamide; 2-[3-(3-Chloro-5-cyaao-phenoxy)-4-methyl-phenyl]-N-[4-(l5l-dioxo-lX6- thiomorpholin-4-yl)-2-methyl-phenyl]-acetamide; 2~[4-CUoro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-[2-chloro-4-(methyl- propionyl-sulfamoyl)-phenyl]-acetamide; 2-[3-(3-CWoro-5-cyano-phenoxy)-4-methyl-phenyl]-N-[2-methyl-4-(2-morpholiri-4-yl- acetyl)-phenyl]-acetamide; compound with trifluoro-acetic acid; 2-[4-Chloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-[2-chloro-4-(3- methoxy-propionylsulfamoyl)-phenyl]-acetamide; sodium salt; 2-[4-Bromo-3-(3-cyano-5-difluoromethyl-phenox7)-2-fluoro-phenyl]-N-(2-chloro-4- sulfamoyl-phenyl)-acetamide; 2-[4-Chloro-3-(3-cyano-5-difluoromethoxy-phenoxy)-2-fluoro-phenyl]-N-(4- sulfamoyl-phenyl)-acetamide; 2-[4-Chloro-3-(3-cyano-5-diflu^ sulfamoyl-phenyl)-acetamide; 2-[4-Chloro-3-(3-chloro-5--cyano-phenoxy)-2-fluoro-phenyl]-N-(2-chloro-4-methylsulfamoyl-phenyl)-acetamide; 2-[4-Bromo-3-(3-cyano-5-difluorometh^ sulfamoyl-phenyl)-acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)-4-methyl-phenyl] -N-[4-( l,l-dioxo-1^6-isothiazoIidin-2-yl)-2-methyl-phenyl]-acetamide; 2-[4-Chloro-3-(3-chloro-5'q^ano-phenoxy)-2-fluoro-phenyl]-N-{2-chloro-4-[(2-methoxy- acetyl) -methyl-sulfamoyl] -phenylj-acetamide; 2- [4-Chloro-3-(3«chloro-5-cyano-phenoxy)-2-fluoro-phenyi] -N-{ 2-chloro-4- [ (3-methoxy-propionyl)-methyl-sulfamoyI] -phenyl} -acetamide; 2-[4-Chloro-3-(3-chloro-5-cyaao-phenoxy)-2-fluoro-phenyl]-N-(2-chloro-4-pentanoylsulfamoyl-phenyl) -acetamide; sodium salt; 2-[4-Chloro-3-(3-cMoro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-[2-cUoro-4-(3-metiyl-butyrylsulfamoyl)-phenyl] -acetamide; sodium salt; 2-[4-Chloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-[2-chloro-4-(2- dielitylaxiiino-acetylsiilfamoyl)-plienyl] -acetamide; compound with hydrochloric acid; 2-[4-Chloro-3-(3-chloro-5»cyano-phenoxy)-2-fluoro-phenyl]--N-[2-chloro-4-(4-methyl- pentanoylsulfamoyl)-phenyl]-acetamide; sodium salt; 2-[4-Chloro-3-(3-chloro-5»cyano-phenoxy)-2-fluoro-phenyI]-N-[2-chloro-4-(2- morpholin-4-yl-acetyIsulfamoyl)-phenyl]-acetamide; compound with hydrochloric acid; N-(4-{2-[3-(3-Chloro-5-cyano-phenoxy)-4-methyl-phenyl]-acetylamino}-3-methyl- phenyl)-oxalamic acid ethyl ester; N-(2-CUoro-4-sulfamoyl-phenyl)-2-[3-(3-cyano-5-difluoromethyl-phenoxy)-4-ethyl-2- fiuoro-phenyl] -acetamide; 2-[3-(3-Cyano-5-difluoromethyl-phenoxy)-4-ethyl-2-fluoro-phenyl]-N-(2-methyl-4- sulfamoyl-phenyl) -acetamide; N-{4-[(3-Amino-propionyl)-methyl-sulfamoyl]-2-chloro-phenyl}-2-[4-chloro-3-(3- chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-acetamide; compound with hydrochloric acid; 2- [3-(3-Chloro-5-cyano-phenoxy)-4,5-dimethyl-phenyl] -N-(4-sulfamoyl-phenyl)- acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)-4,5-dimetiiyl-phenyl]-N-(2-methyl-4-sulfa phenyl)-acetamide; 2-[3-(3-CUoro-5-cyano-phenoxy)-4>5-dimethyl-phenyl]-N-(2-chloro-4-sulfamoyl- ?henyl)-acetamide; ?-[3_(3-Bromo-5-cyano-phenox7)-4-chloro-2-fluoro-phenyl]-N-(2-methyl-4-sulfamoyl- phenyl) -acetamide; 2-{4-Chloro~3-[3-cyano-5-(3-hydro methyl-4-sulfamoyl-phenyl)-acetamide; 2-{4-CHoro-3-[3-cyano-5-(3-dimethylainin^ N- (2 -methyl-4-sulfamoyl-phenyl) -acetamide; 4-(3-Chloro-4-{2-[4-chloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]- acetylamino}-benzenesxilfonylaniino)-4-oxo-butyricacid; 2-[4-Bromo-3-(3-cHoro-5-cyano-phenoxy)^ phenyl)-acetamide; 2-[3-(3-Chloro-5-cyano-phenox7)-2-fluoro-4-methoxy-phenyl]-N-(2-chloro-4- sulfamoyl-phenyl)-acetamide; 2-[3-(3-CUoro-5-q^ano-phenoxy)-2-fluorO"4-methoxy-phenyl]-N-(2-methyl-4- sulfamoyl-phenyl)-acetamide; 2- [4-CMoro-3- (3-cUoro~phenoxy)-phenyl] -N-phenyl-acetamide; 2-[3-(2-Bromo-5-chloro-phenoxy)-4-chloro-phenyl]-N-(4-sulfamoyl-phenyl)-- acetamide; 2-[4-CUoro-3-(3,5-dicyano-phenoxy)-phenyl]-N-(2-pyrrol-l-yl-phenyl)-acetamide; 2-[4-Chloro-3-(3>5«dicyrano-phenoxy)-phenyl]-N-(2-fluoro-phenyi)-acetamide; 2-[4-Chloro-3-(3>5-dicyano-phenoxy,)-phenyl]-N-(2-methoxy-phenyl)-acetamide; 2-[4-Chloro-3-(3,5»dicyano-phenoxy)-phenyl]-N-(2-isopropyl-phenyl)-acetamide; 2-[4-Chloro-3-(3>5-dicyano-phenoxy)-phenyl]-N-o-tolyl-acetamide; 2-[4-Chloro-3-(3>5-dicyano-phenox7)-phenyl]-N--(2-ethyl-phenyl)--acetamide; 2-[4-CMoro-3-(3,5-dkyano-phenoxy)-phenyl]^ 2-[4-CUoro-3-(3,5-dicyano-phenoxy)-phenyl]-N-(4-metiioxy-2-methyl"phenyl)- acetamide; 2-[4-Chloro-3-(3,5-dicyano-phenoxy)-phenyl]-N-(4-cyclohexyl-phenyl)-acetar^ 2-[4-Chloro-3-(3,5-dicyano-phenox7)-phenyl]-N-(2-cyano-phenyl)-acetamide; 2- [4-Chloro-3-(3,5-dicyano-phenoxy)-phenyl] -N-(2-trifluoromethyl-phenyl) -acetamide; 2-{2-[4-CWoro-3-(3,5-dicyano-phenoxy)-pta^ acid methyl ester; 2-[3-(3-Chloro-5-cyano-phenoxy)-4-ethyl-phenyl]-N-phenyl-acetamide; 2-[3-(2-Chloro-3,5-dicyano-phenoxy)-4-ethyl-phenyl]-N-phenyl-acetamide; 2-[4-Chloro-3-(2,5-dichloro-benzyl)-phenyl]-N-(2-chloro-4-sulfamoyl-phenyl)-acetamide; i 2-[3-(3-Chloro-5-cyano-phenoxy)-4-methoxy-phenyl]-N-phenyl-acetamide; 2- [4-Chloro-3-(3,5-dicyano-phenoxy)-phenyl] -N-phenyl-acetamide; 2-[4«Chloro-3-(3>5-dicyano-phenox7)-phenyl]«N-(4-methyl--3-sulfamoyl-phenyl)-acetamide; 2-[4-Chloro-3-(3,5-dicyano-phenoxyr)-phenyl]-N-(3-methanesulfonyl-phenyl)- acetamide; (4-{2-[4-CMoro-3-(3,5-dicyano-phe^ methyl ester; 3-(4-{2-[4-CMoro-3-(3,5-dicyano-pheno:xy)^^ add methyl ester; (4-{2-[4-CHoro-3~(3,5-dicyano-pheno^ acid methyl ester; 4-(4-{2-[4-CMoro-3-(3j5-dicyano-pheno;^ methyl ester, 2-[4-Chloro-3-(3>5-dicyano-phenoxy^ acetamide; (4-{2-[4-Chloro-3-(3,5"dicyano-phenoxy')-phenyl]-acetylamino}-phenyl)-aceticacid methyl ester; 2- [4-Chloro-3-(3>5-dicyano-phenoxy)-phenyl] -N-(4-cyano-phenyl)-acetamide; 4-{2-[4-CUoro-3-(3,5-dicyano-phenoxy)-phenyl]-acetylamino}-benzoic acid methyl ester, 2-[4-Chloro-3-(3,5-dicyano-phenoxy)-phenyl]-N-(4-hydroxy-phenyl)-acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)«4-methyl-phenyl]-N-(4-meliyl-pyridiii»3-yl)- acetamide; 2-[3-(3-CUoro-5-cyano-phenoxy)"4-methyl-phenyl]-N-(3-methyl-pyridin«2-yl)- acetamide; 2-[3-(3-CUoro-5-cyano-phenoxy)-4-metiiyl-phenyl]-N-(2>5-dimethyl-2H-pyrazol-3-y0 acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)-4-me1^ acetamide; N-(6-Acetylamino-4-methyl-pyridm^ phenyl] -acetamide; 2-[3-(3-Chloro-5- 3-yl)-acetamide; 2-[3-(3-CHoro-5-cyano-pheno:xy)-4-met^^ 2H- [ 1 A4]triazol-3-yl)-acetamide; N-(2-Chloro-phenyl)«2-[3-(3,5-dichloro-benzoyl)-5-methyl-phenyl]-acetamide; 2-[3-(3,5-Dichloro-benzoyl)-5-methyl-phenyl]-N-(2-methyl-4-sulfamoyl-phenyl)- acetamide; (4-{2-[3-(3-Chloro-5-cyano-phenoxy)-4-methyl-phenyl]-acetylamino}-3-methyl- phenoxy)-acetic acid; (3-Chloro-4-{2-[3-(3-cUoro-5-cyano-phenoxy)-4-metiiyl-phenyl]-acetylamino}- phenyl)-acetic acid methyl ester; (3-CUoro-4-{2-[3-(3-chloro-5-cyano-phenoxy)-4-methyl-phenyl]-acetylamino}- phenyl)-acetic acid; 2-[3-(3-CMoro-5-cyano-phenoxjr)-4-m methyl-phenyl)-acetamide; 2- [3-(3-Chloro-5-cyano-phenoxy)-4-metiiyl-phenyl] -N- [4-(methanesulfonyl-methyl- amino)-2-methyl-phenyl] -acetamide; 4-{2-[4-Chloro-3-(3-cUoro-5-q7ano-phenoxy)-2-fiuoro-phenyl]-acetylaxnino}-3--methyl-benzamide; 2-[7-(4-Chloro-benzoyl)-2,3-dihydro-benzofuran-5-yl]-N-(2-chloro-phenyl)-acetamide; 2-[7-(4-Chloro-benzoyl)-2,3-dihydro-benzofuran-5-yl]-N-(4-sulfamoyl--pheiiyl)- acetamide; 2-[4-Chloro-3-(3,5--diq^ano-phenylsiilfanyl)-phenyl]-N-(4-sulfarnoyl-phenyi)- acetamide; 2-[3-(2*Bromo-5 acetamide; 2-[3-(2"Bromo-5-chloro-phenylsulfanyl)-4-chloro-phenyl]-N-(2-chloro-phenyl)- acetamide; 2-[4-Chloro-3-(3>5"dichloro-benzoyl)-pheiiyl]-N-(2-"chloro--plienyl)-acetamide; 2"[4-Chloro-3-(2>5-dichloro-benzoyl)-phenyl]-N-(2-chloro-phenyl)-acetamide; 2«[4-Chloro-3-(2>5-dicUoro-benzoyl)-phenyl]-N-(2'methyl-4-sulfamoyl-phenyl)- acetamide; 2-[4-Chloro-3-(2,5-dichloro-benzoyl)-phenyl]-N-(4-sulfamoyl-phenyl)«acetamide; 2- [4-Chloro-3-(2,5-dicHoro-benzoyl)-phenyl] -N-phenyl-acetamide; 2-[4-Chloro-3-(3,5-dicUoro-benzoyl)-phenyl]-N-(2-metiiyl-4-sulfamoyl-phenyi)- acetamide; 2-[4-Chloro-3-(2,5-dichloro-benzoyl)-phenyl]-N-(2-chloro-4-sulfamoyl-phenyl)- acetamide; 2-[3-(4-CUoro-benzo)d)-5-methyl-phenyl]-N-(4-sulfamoyl-phenyl)-acetamide; 2-[3-(4^hloro-benzoyl)-5~methyl-phenyl]^ acetamide; 2.[3-(2-CWoro-benzoyl)-5-metiiyl-phenyl]-N-(2-me1iiyl-4"Siilfamoyl-phenyl)- acetamide; 2-[3-(4-CUoro-benzoyl)-5-methyl-phenyI]-N-(2-chloro-4-sulfainoyl-phenyl)- acetamide; 2-[3-(4-Chloro-benzoyl)-5-methyl-phenyl]-N-(2-chloro-phenyl)-acetamide; 2-[3-(2-Chloro-benzoyl)-5-methyl-phenyl]-N-(2-chloro-phenyl)-acetarnide; 2-[3-(3-Chloro-benzoyl)-5-methyl-phenyl]-N-(2-methyl-4-sulfamoyl-phenyl)- acetamide; 2-[3-(3-Chloro-benzoyl)-5-methyl-phenyl]-N-(4-sulfamoyl-phenyl)-acetamide; 2"[3-(3-CHloro-benzoyl)-5-methyl-phenyl]-N-(2-chloro-phenyl)-acetainide; 2-[3-(2-CHoro-benzoyl)-5-me1^ 2-[3-(5-Bromo-2-cHoro-benzoyl)-4^ phenyl)-acetamide; 2-[3-(5-Cyano-2-meihyl-benzoyl)-4-methyl^ acetamide; 2-[3-(5-Cyano-2-methyl-benzoylM-me N-(2-Chloro-phenyl)-2-[3-(5-q^ano-2-methyl-beiizoyl)-4-metiiyl-phenyl]-acetamide; 2-[3-(5-Cyano-2-ethyl-benzoyl)-4-ethyl-pheny^^ acetamide; 2- [3-(3 >5-Dichloro-benzoyl)-5-methyl-phenyl] -N-(4-sulfamoyl-phenyl)-acetamide; or 2-[3-(3-Chloro-5-q^ano-plienoxy)-2-fluorO"4-methyl-phenyl]»N-(2-chloro-4- propionylsulfamoyl-phenyl)-acetamide; sodium salt 6, Use of compound of formula I according to claim 5> which is 2- [4-chloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl] -N- (2-chloro-4-sulfamoyl- phenyl)-acetamide; 2-[4-chloro-3-(3-chloro-5-cyano-phenoxy)«2-fluoro-phenyl]-N-(2-chloro-4- propionylsulfamoyl-phenyl)-acetamide; sodium salt; 2-[3-(3-cUoro-5-cyano-phenoxy)-2-fluoro-4- phenyl)-acetamide; 2-[4-bromo-3«(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-chloro-4-sulfamoyl- phenyl)-acetamide; 2-[4-bromo-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-chloro-4- propionylsulfamoyl-phenyl)-acetamide; sodium salt; N-(4-butyrybtdfamoyl-2-cUoro-phenyl)-2«[4-chloro-3-(3-chloro-5-cyano-phenoxy)-2- fluoro-phenyl]-acetamide; sodium salt; N-[4-((S)-2-amino-3-methyl-butyrylsulfamoyl)-2-cUoro-phenyl]-2-[4-chloro-3-(3- chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-acetamide; sodium salt; N-(2-chloro-4-sulfamoyl-phenyl)-2-[3-(3-cyano-5-difluoromethyl-phenoxy)-4-ethyl-2- fluoro-phenyl] -acetamide; 2-[3-(3-cyano-5-difluoromethyl-phenoxy)-4-ethyl-2-fluoro-phenyl]-N-(2-methyl-4- sulfamoyl-phenyl)- acetamide; 2-[4-bromo-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-methyl-4-sulfamoyl- phenyl)-acetamide; 2-[4-bromo-3-(3-cyano-5-difluoromethyl-phenoxy)-2-fluoro-phenyl]-N-(2-methyl-4- sulfamoyl-phenyl)-acetamide; 2-[4-bromo-3-(3-cyano-5-difluoromethyl-phenoxy)-2-fluoro-phenyl]-N-(2-chloro-4- suifamoyl-phenyl)-acetamide; 2-[4-cUoro-3~(3-cyano-5-difluorome^ sulfamoyl-phenyl) - acetamide; 2-[3-(3-cMoro-5-cyano-phenoxy)-2-fluoro-4-metiioxy-phenyl]-N-(2-cUoro-4-sulfamoyl-phenyl)-acetamide; 2-[3-(3-cUoro-5-cyano«phenox7)-2*fluoro-4-metiiox7-phenyl]-N-(2-methyl-4-sulfamoyl-phenyl)- acetamide; or, 2-[3«(3-cHoro-5-q^ano-phenoxy)-2-fluoro-4-methyl-phenyl]-N-(2-chioro-4" propionylsulfamoyl-phenyl)-acetamide; sodium salt wherein X1 is -O-; Rl and R2 are each independently selected from the group consisting of hydrogen, Q-6 alkyi, Ci^haloalkyl, C3.8 cycloalkyl, Ci,6 alkoxy, Q.6 alkylthio, C^ alkylsulfinyl, Q-6 sulfonyl, Q^ haloalkoxy, Q.6 haloalkylthio, halogen, amino, alkylamino, dialkylamino, aminoacyl, nitro and cyano; or, (ii) together R1 and R2 are -0-CH=CH- or -O-CH2CH2- provided that R1 is not hydrogen; R3 and R4 are independently selected from the group consisting of hydrogen, G\.6 alkyi, Q.6 haloalkyl, Q-6 alkoxy, Q-e haloalkoxy Q-6 alkylthio, Ci.6 haloalkylthio, halogen, amino, nitro and cyano; R5 is aryl substituted with one to three substituents independently selected from the group consisting of Q-6 alkyi, C2-6 alkenyl, C2-6 alkynyl, -OCCH2OH, -OCCH2NMe2, Q_6 haloalkyl, C3.8 cycloalkyl, Ci.6 alkoxy, Cu6 alkylthio, Q.6 alkylsulfinyl, Q.6 sulfonyl, Q-e haloalkoxy, Q-e haloalkylthio, hydroxy, halogen,, nitro and cyano, said alkyi and said cycloalkyl are optionally substituted with one or two substituents independently selected from the group consisting of alkyi, hydroxy, alkoxy, thiol, alkylthio, halogen, amino, alkylamino, dialkylamino, amino alkyi, alkylaminoalkyl, and dialkylamino; Ar is a substituted phenyl ring according to formula Ha with the proviso that R7a and R7c are not both hydrogen or if R7c is hydrogen, then R7a is chlorine: R7a is selected from the group consisting of hydrogen, Q-6 alkyl, Q-3 haloalkyl, C1.6 alkoxy, Q-6 haloalkoxy, halogen and cyano; R7 is independently selected from the group consisting of Q-$ haloalkyl, Q,6 alkoxy, Q-6 alkylthio, Q-6 alkylsulfinyl, Q.6 sulfonyl, amino Q_6 alkylsulfonyl, S02NRUaRllb, Q-6 haloalkoxy, Q-e haloalkylthio, hydroxy, amino, Q.6 alkylamino, Q-6 dialkylamino, aminoacyl, acyl, CONR8R , nitro, cyano, Q.6 heteroalkoxy, -X2(GH2)pS(0)2NR8R9, -X2(CH2)pNHC(0)NHR8R9, -X2(CH2)pNHS(0)2NR8R9 and -X2(CH2)pNHCOOR10; R7c is selected from the group consisting of Q-e heteroalkoxy, -S(0)2NR8R9, -X2CH2(CH2)pS(0)2NR8R9; -X2(CH2)pNHC(0)NHR8R9, X6(CH2)vCONR8R9, -S02R13, -NR8R9, X2(CH2)pNRuS(0)2NR8R9, -X2(CH2)pNHCOOR10, -X6(CH2)vCOOR10, -X6(CH2)VCN, -OR15 and C(=0)CH2N[(CH2)2]2X4; R8 and R9 taken independently, one of R8 and R9 is hydrogen or Q-6 alkyl and the other of R8 and R9 is selected from the group consisting of hydrogen, -C(=0)R14, -C(=0)CR12NH2) -(CH2)2N[(CH2)2]20, COC02Me, CM cycloalkyl said cycloalkyl optionally substituted with one or two hydroxyl substituents, pyranyl, Q-6 alkyl and aryl said alkyl and said aryl groups optionally substituted with one or two substituents independently selected from the group consisting of hydroxy, Q.6 alkoxy, thiol, Q-6 alkylthio, Q-e alkylsulfinyl, Q_e sulfonyl, and halogen; or, taken together are (CH2)rX5-(CH2)2, -(CH2)0- or (CH2)rS(0)n optionally substituted with one or two substituents selected from the group consisting of halogen, hydroxyl and NRUaRub; R10 is Q-6 alkyl; R11 is hydrogen or Q-6 alkyl; Rlla and Rub are independently R11; R12 is the sidechain of a naturally occurring D-amino acid; R13 is Q_6 alkyl; -(CH2)sC02Rn, -(CH2)2CN, -(CH2)2NH2, -(CH2)uOH; Rw is Q.10 alkyJ, -(CH2)sNHRUaRnb, -(CH2)sORu, -CH2CH(OH)CH3, -CH2N[(CH2)2]20, -(CH2)2C02R11> optionally substituted phenyl or pyridinyl; R" is Ci-6 aikyi substituted with one to three hydroxyl groups; X2 is -O-or a bond; X4 is -O- or -NMes X5 is-0-,-S(0)n-orNRu; X6 is O- or -S(0)n-; m is an integer from 0 to 2; n is an integer from 0 to 2; o is an integer from 4 to 6; p is an integer from 0 to 6; r is an integer from 3 to 4 s is an integer from 1 to 2; u is an integer from 2 to 3; v is an integer from 2 to 6; and, hydrates, solvates, and acid addition salts or salts of the conjugate base thereof. 8. Compound of formula la according to claim 7, wherein X1 is -0-; R1 and R2 are each independently selected from the group consisting of hydrogen, Q_6 alkyi, Q-6 alkoxy and halogen; or, together R and RT are -0-CH=CH-, provided that R1 is not hydrogen; R3 and R4 are independently selected from the group consisting of hydrogen, and halogen; R5 is aryl substituted with one to three substituents independently selected from the group consisting of Q-6 alkyi, -OCCH2OH> -C^CCH2NMe2> Q.6 haloalkyl, Q-6 haloalkoxy, cyano and halogen; Ax is a substituted phenyl ring according to formula Ha with the proviso that R7a and R7c are not both hydrogen or if R7c is hydrogen, then R7a is chlorine: R7a is selected from the group consisting of hydrogen, Q.6 alkyl, C1-3 haloalkyl, Ci_6 alkoxy, Q-6 haloalkoxy, halogen and cyano; R is independently selected from the group consisting of Q_6 haloalkyl, Q-6 alkoxy, Q.6 alkylthio, Q_6 alkylsulfinyl, Q.6 sulfonyl, amino Q-6 alkylsulfonyl, S02NRUaRub, Q-6 haloalkoxy, Q-6 haloalkylthio, hydroxy, amino, Q_6 alkylamino, C1-6 dialkylamino, aminoacyl, acyl, CONR R , nitro, cyano, Q-6 heteroalkoxy, -X2(CH2)pS(0)2NR8R9, -X2(CH2)pNHC(0)NHR8R9, -X2(CH2)PNHS(0)2NR8R9 and -X2(CH2)pNHCOOR10; R7c is selected from the group consisting of Q-6 heteroalkoxy, -S(0)2NR8R9, -X2CH2(CH2)pS(0)2NR8R9; -X2(CH2)pNHC(0)NHR8R9, X6(CH2)vCONR8R9, -S02R13, -NR8R9, X2(CH2)pNRnS(0)2NR8R9, -X2(CH2)PNHCOOR10, -X6(CH2)VCOOR10> -X6(CH2)VCN, -OR15 and C(=0)CH2N[(CH2)2]2X4; R8 and R9 taken independently, one of R8 and R9 is hydrogen or Q-6 alkyl and the other of R8 and R9 is selected from the group consisting of hydrogen, -C(=0)R14, -C(=0)CR12NH2, -(CH2)2N[(CH2)2]20, COC02Me, CM cycloalkyl said cycloalkyl optionally substituted with one or two hydroxyl substituents, pyranyl, Q_6 alkyl and aryl said alkyl and said aryl groups optionally substituted with one or two substituents independently selected from the group consisting of hydroxy, Q-6 alkoxy, thiol, Q_6 alkylthio, Q-6 alkylsulfinyl, Q.6 sulfonyl, and halogen; or, taken together are (CH2)2-X5-(CH2)2, -(CH2)0- or (CH2)rS(0)n optionally substituted with one or two substituents selected from the group consisting of halogen, hydroxyl and NRllaRllb; R10 is Q-6 alkyl; R11 is hydrogen or Q-e alkyl; RUa and Rllb are independently Ru; R " is the sidechain of a naturally occurring D-amino acid; R13 is Q.6 alkyl; -(CH2)sC02Rn, -(CH2)2CN, -(CH2)2NH2j -(CH2)uOH; R14 is CMO alkyl, -(CH2)sNHRUaRub> -(CH2)sORn, -CH2CH(OH)CH3) -CH2N[(CH2)2]20, -(CH2)2C02Rn, optionally substituted phenyl or pyridinyl; R15 is Ci-6 alkyl substituted with one to three hydroxyl groups; X" is-O-or a bond; X4 is -O- or -NMe-; X5 is-O-,-S(0)n-orNRn; X6 is O- or -S(0)n-; m is an integer from 0 to 2; n is an integer from 0 to 2; o is an integer from 4 to 6; p is an integer from 0 to 6; r is an integer from 3 to 4 j s is an integer from 1 to 2; u is an integer from 2 to 3; v is an integer from 2 to 6; and, hydrates, solvates, and acid addition salts or salts of the conjugate base thereof. 9, Compound of formula la according to claim 8, wherein X1 is -O-; R1 and K are each independently selected from the group consisting of hydrogen, methyl, ethyl, i-propyl, methoxy, chloro and bromo; or together R and R are -0-CH=CHs R3 and R4 are independently selected from the group consisting of hydrogen and fluoro; propoxy) -phenyl] -acetamide; 2-[3-(2-Bromo-5-chloro-phenoxy)-4-cUoro-phenyl]-N-(4-sulfamoyl-phen acetamide; 2-[4-Chloro-3-(3,5-chcyano-phenoxy)-ph^ 2-[4-CHoro-3-(3,5-dicyano-phenoxy)-phenyl]-N^^ 2-[3-(2-CHoro-5-cyano-pheno:xy)-4-ethyl^^^ acetamide; 2-[4"Chloro-3-(2,5"dicyano-phenoxy)-2-fluoro-phenyl]-N-(4-sulfamoyl-phenyi)- acetamide; 2-[4-Chloro-3-(3,5-dicyano-phenoxy)-2-fluoro-phenyl]-N-(4-sxilfamoyl"phenyl)- acetamide; 2-[4-Chloro-2-fluoro-3-(2,3,5-1xicMoro-phenoxy)-phenyl]-N-(4-sulfamoyl-phenyl)-- acetamide; 2-[3-(3-Cyano-5-fluoro-phenoxy)-4-meliiyl-phenyl]-N-(4-sulfamoyi-phenyl)- acetamide; N-(2-Chloro-phenyl)«2-[3-(3-cyano-5-fluoro-phenoxy)-4-meliyl-phenyl]-acetaniide; 2«[4»CWoro-3-(3-cyano-5-difluoromethyl-phenoxy)--2--fluoro-phenyl]-N-(4«sulfamoyl» phenyl)-acetamide; 2-[4-Chloro-3-(3-cyano-5-difluoromethyl-phenoxy)-2-fluoro-phenyl]-N-(2-chloro- phenyl)-acetamide; 2-[3-(2-Bromo«5-Chloro-phenoxy)-4-ethyl-phenyl]-N-(4-sulfamoyl-phenyl)-acetamide; 2-[3-(2-Bromo-5-Chloro-phenoxy)-4-ethyl-phenyI]-N-(2-Chloro-phenyl)-acetamide; 2-[3-(5-Chloro*2-cyano-phenoxy)-4-etiiyl-phenyl]-N-(4«sdfamoyl-phenyl)-acetamide; 2-[3-(5-Chloro-2-cyano-phenoxy)-4-ethyl-phenyl]-N-(2-chloro-phenyl)-acetaniide; 2-[3-(2,5-Dichloro«phenoxy)-4-etiyl-phenyl]-N-(4-sidfamoyl-phenyl)-acetaniide; 2-[3-(2,6-Dichloro-phenoxy)-4-ethyl-phenyl]-N-(4-sulfamoyl-phenyl)-acetamide; N-(2-Chloro-phenyl)-2-[3-(2,5-dichloro-*phenoxy)-4-ethyl-phenyl]-acetamide; 2-[3-(3-Bromo-5-chioro-phenoxy)-4-ethyl-phenyl]-N-(4-sulfamoyl"phenyl)-acetaxm N-(2-Chloro-phenyl)-2-[3-(2,6-dichloro-phenoxy)-4-ethyl-phenyl]-acetamide; 2-[3-(3-Bromo-5-Chloro-phenoxy)-4-ethyi-phenyl]-N-(2-ddoro-phenyl)-acetamide; N-(2-Chloro-ptenyl)-2-[3-(33-dicyano-phenoxy)-4«etiiyl-phenyl]-acetamide; 2-[3-(2-Bromo-5-chloro-phenoxy)-4-isopropyl-phenyl]-N-(4-sulfamoyl-phenyl)- acetamide; 2-[3-(2-Bromo-5-Chloro-phenoxy)-4-isopropyl-phenyl]-N-(2-chloro-phenyl)- acetamide; 2-[4-Chloro-3-(3,5-dicyano-phenoxy)-2-fluoro-phenyl]-N-(2-chloro-phenyl)- acetamide; 2-[4-ChIoro-3-(3,5-dicyano-pheno^ phenyl] -acetamide; 2-[3-(2-Bromo-5-cMoro-phenoxy)-4-meli7l-phenyl]-N-(4-siilfamoyl-phenyi)- acetamide; 2-[3-(2-Bromo-5H;Horo-pheno:xy)-4-me^ phenyl)-acetamide; 2^4-Cldoro-3-(3,5-dicyano-phenoxy)^ phenyl)-acetamide; 2-[3-(2-Bromo-5-cMoro-phenoxy)-4-methyl-phenyl]-N-(2-cHoro-phenyl)-acetainid^ N-(2-Chloro-phenyl)-2-[3-(3>5-dicyano-phenoxy)^-meliiyl-phenyl]-acetaxnide; 2-[3-(3-Bromo-2,5-dichloro-phenoxy)-4-ethy^ acetamide; 2-[3-(3-Bromo-2,5-dicMoro-phenoxy)-4^ phenyl)~acetamide; 2-[3-(3-Bromo-2,5-diChloro-phenoxy)-4-ethyl«phenyl]-N-(2-Chloro-phenyl)-acetaniide; N-(2-Chloro-phenyl)-2-[3-(3,5-dibromo-2-cM^ 2-[3-(5-Bromo-2-chloro-3-fluoro-phenoxy)-4-ethyl-phenyl]-N"(4-sulfamoyl-phenyl)- acetamide; 2-[3-(5-Bromo-2-cMoro-3-fluoro-phenoxy)-^ phenyl)»acetamide; 2-[3-(5-Bromo-2-Chloro-3-fluoro-phenoxy)-4-ethyl-phenyl]-N-(2-chloro-phenyl)- acetamide; 2-[4-CWoro-3-(3-Chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-methyl-4-sxdfamoy phenyl)-acetamide; 2-[3-(3,5-Dicyano-phenoxy)-4-methyl-phenyl]-N-(2-metiyl-4-sulfamoyl-phenyl)- acetamide; N-(2-CWoro-4-sdfamoyl-phenyl)-2-[3-(3,5^ acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)-4-e^ 2-[3-(3 acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)-4-et^ acetamide; 2-[3-(3-CHoro-5-cyano-phenoxy)-4-etiiyl-phenyl]-N-(4-methylsulfamoyl-phenyl)- acetamide; 2-[3-(2-Chloro-5-q^ano-3-fluoro-phenoxy)-4-ethyl-phenyl]-N-(4-sulfamoyl-phenyl)- acetamide; 2-[3-(2-Chloro-5-cyano-3-fluoro-phen phenyl)-acetamide; 2-[4-Chloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-methyl-4- propionylsulfamoyl-phenyl)-acetamide; 2-[3-(2-CHoro-3,5-diq^ano-phenox7)-4-eth7l-phenyl]-N-(4-sulfamoyl-phen7l)-acetamide; 2-[3-(2-Chloro-3>5-di 2-[3-(2-CHoro-3,5-dicyano-phenoxy)^ phenyl)-acetamide; 2-[4-CWoro-3-(4-cyano-2,6-dimetiyl-phenoxy)*phenyl]-N-(4-sulfamoyl-phenyl)- acetamide; 2-[4-Chloro-3-(4-cyano-2,6-dimetiyl-ph^^ phenyl)-acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)-4-metiioxy-phenyl]-N-(4-sulfamoyl-phenyl)- acetamide; 2-[3-(3-CWoro-5-q^ano-phenoxy)-4-ettyl-phenyl]-N-(2-Chloro-phenyl)-acetainide; 2-[3-(2-Chloro-5-cyano-3-fluoro-phenoxy)-4-ethyl-phenyl]-N-(2--chloro-phenyl)- acetamide; 2-[3-(2-CMoro-3,5-diq^ano-phenoxy)-4-etiiyi-phenyl]-N-(2-chloro-phenyl)-acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)-4-metiioxy-phenyl]-N-(2-cMoro-phenyl)-acetamide; 2-[3-(2-Chloro-5-cyano-phenoxy)-4-metiioxy-phenyl]-N-(2-Chloro-phenyl)-acetamide^ 2-[4-Bromo-3-(3-chloro-5-q^ano-phenoxy)-2-fluoro-phenyl]-N-(2-chlorO"4- propionylsulfamoyl-phenyl)-acetamide; sodium salt; 2-[3-(3-Chloro-5-cyano-phenoxy)-4-methoxy-phenyl]-N-(2-chloro-4-sulfamoyl-- phenyi)-acetamide; 2-[3-(2-Chloro-5-cyano-phenoxy)-4-methoxy-phenyl]-N-(4-sulfamoyl-phenyI)- acetamide; 2-[3-(2-Chloro-5-cyano-phenoxy)-4-methoxy-phenyl]-N-(2-methyI-4-sulfamoyl- phenyl)-acetamide; 2-[3-(2-Chloro-5-c^ano-phenoxy)-4-methoxy-phenyl]-N-(2*Chloro-4-sulfamoyl- phenyl) -acetamide; 2-[4-Chloro-3-(4-cyano-2,6-dimethyl-pte^ acetamide; 2-[4-Chloro-3-(3,5^cyano-phenoxy)-phenyl]*N-(4-methylsulfamoyl-phenyl)- acetamide; 2-[4-CMoro-3-(3,5-dicyano-phenoxy)-pte^ acetamide; 2-[4-CHoro-3-(3,5-dicyano-pheno:xy)~ph^^ acetamide; 2-[4XUoro-3-(3,5-dicyano-phenoxy)-phe^ acetamide; 2^[3-(3-Chloro-5-cyano-phenoxy)-4-melJioxy-phenyl]-N-(2-methyl-4-sulfamoyl- phenyl) -acetamide; 2-[3-(3-CMoro-5-cyano-phenoxy)-2-fluoro^ sulfamoyl-phenyI)-acetamide; 2-[4-CHoro-34'3-cyano-5-difluoromethyI^^^ sulfamoyl-phenyl)-acetamide; 2-[4-CHoro-3-(3,5-di(7ano-pheno:xy)-pta acetamide; N-[4-( (S)-2-Amino-3-methyl-butyrylsdfamoyl)-2-methyl-phenyl] chloro-5-q^ano-phenoxy)-2-fluoro-phenyl]-acetamide; compound with hydrochloric acid; 2-[4-CWoro-3-(3,5-dicyano-phenoxy)-phenyl]-N-(4-cyanometiioxy-phenyl)-acetainide; 2-[4-Chloro-3-(3,5-dicyano-phenoxy)-phenyl]-N-(4-methanesulfonyl-phenyl)- acetamide; 3-Chloro-4-{2~ [4-chloro-3-(3,5-dicyano-phenoxy)-phenyl] -acetylamino}-benzoic acid methyl ester; 2-[4-Chloro-3-(3>5-dicyano-phenoxy)-phenyl]-N-{4-[(2-hydroxy-ethyl)-methyl- sulfamoyI]-phenyl}-acetamide; 2-[4-Chloro-3-(3,5-dicyano-phenoxy)-phenyl]-N-[4-(4-hydroxy-piperidine-l-sulfonyl) phenyl] -acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)-2-fluoro^-metiiyl'phenyl]-N-(2-Chloro-4-siilfamoyl- phenyl)-acetamide; N-(2-Chloro-4-sulfamoyl-phenyI)-2-[3-(3-cyano-5-difluoromethyl-phenoxy)-2-fluoro- 4-methyl-phenyl] -acetamide; 2-[3-(3-Cyano-5-difluoromethyl-phenoxy)-2-fluoro-4-methyl-phenyl]-N-(2-methyl-4- sulfamoyl-phenyl)-acetamide; N-(2-Chloro-phenyl)-2-[3-(3-cyano-5-difluoromethyl-phenoxy)-2-fluoro-4-methyl- phenyl] -acetamide; 2-[4-Chloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-{2-methyl-4- [(pyridine-3-carbonyl)-sulfamoyl]-phenyl}-acetamide; compound "with hydrochloric acid; 2-[4-Chloro-3-(3-cyano-5-trifluoromethyl-phenoxy)-phenyI]-N-(4-sulfamoyl-phenyl)- acetamide; 2-[4-Chloro-3-(3-cyano-5-trifluoromethyl-phenoxy)-phenyl]-N-(2-methyl-4-sulfamoyl- phenyl)-acetamide; 2-[4-Chloro-3-(3-cyano-5-trifiuoromethyl-phenoxy)-phenyl]-N-(2-chloro-4-sulfamoyl- phenyl)-acetamide; 2-[3-(3-Cyano-5-difluoromethyl-phenoxy)-4-ethyl-phenyl]-N-(4-sulfamoyl-phenyl)- acetamide; 2-[3-{3-Cyano-5-difluoromethyl-phenoxy)-4-methoxy-phenyl]-N-(4-sulfamoyl- phenyl)-acetamide; 2-[3-(3-Cyano-5-cMuoromethyl-ph^^ sidfamoyl-phenyl)-acetamide; N-(2-Chloro-4-sulfamoyl-phenyl)-2-[3-(3-c^^ methoxy-phenyl] -acetamide; 2-{4-Chloro-3»[3-cyano-5-(l>l-difluoro-ethyl)-phenox7]-2-fluoro-phenyl}-N-(4-sulfamoyl-phenyl)- acetamide; 2-{4-Chloro-3-[3-cyano-5-(l>l-difluoro-ethyl)-phenoxyr]-2-fluoro-phenyl}-N-(2- methyl-4-sulfamoyl-phenyl)-acetamide; 2-{4-Chloro-3-[3-c7ano-5-(lA-di^^ 4-sulfamoyl-phenyl) -acetamide; 2-[4-Chloro-3-(3-chloro-5-cyano-phenoxy)-2-£luoro-phenyl]--N-(2--chloro-phenyl)- acetamide; 2-[4-Chloro-3-(3-Chloro-5-cyano-phenox7)-2-fluoro-phenyl]-N-[2-methyl-4-(methyl-propionyl-sulfamoyl)-phenyl]-acetamide; 2-[4-Chloro-3-(3-Chloro-5-cyano-phenoxy)-2-fluoro«phenyl]*N»(2-cMoro-4-sulfamoyl-phenyl) -acetamide; 2-[3-(3-Cyano-5-difluoromethyl-pheno^ phenyl) -acetamide; 2-[3-(2-Chloro-5-cyano-phenoxy)-5-methoxy-phenyi]-N-(4-sulfamoyl-phenyl)- acetamide; 2-[3-(2-Chloro-5-cyano-phenoxy^ phenyl)-acetamide; 2-[4,5-Dibromo-3-(3-cyano-5-difluoromethyl-phenoxy)-2-fluoro-phenyl]-N-(2-methyl- 4-sulfamoyl-phenyl)-acetamide; 2-[3-(2-CMoro-5-cyano-phenoxy)-5-ethyl-phenyl]-N-(4-sulfamoyl-phenyl)-acetamide; 2-[3-(2-Chloro-5-cyano-phenox7)-5-ethyl-phenyl]-N-(2-methyl-4-sulfamoyl-phenyl)- acetamide; 2-[3-(2-Chloro-5-cyano-phenox7)-5-eAyl-phenyl]-N-(2-cMoro-4"Sulfamoyl-phenyl)- acetamide; 2-[4-Chloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-methyl-4- methylsulfamoyl-phenyl)-acetamide; 2-[4-Bromo-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-chloro-4-sulfamoyl- phenyl)-acetamide; 3-CMoro^-{2-[3-(3-cyano-5-difluorometh^ acetylamino} -benzoic acid; 2-[4-Chloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-chloro-phenyl)-N- methyl-acetamide; N-(2-CKloro-4-melhanesiilfonyl-phenyl)-2-[3-(3-cyano-5-difluorometiiyl-phenoxy)-2- fluoro-4-methyl-plienylj-acetamide; 2-[3-(2-CHoro-5-cyano-phenoxy)-5-metho^ phenyl)-acetamide; 2«[4?5-Dibromo-3-(3-cyano-5-difluorometiiyi-phenox7)-2-fluoro-phenyl]-N-(4- sulfamoyl-phenyl)-acetamide; 2-[3-(3-CHoro-5-cyano~phenoxy)-4-methyl-pheny^ sulfonyl) -phenyl] -acetamide; 2-[3-(3-CHoro-5-cyano-phenoxy)-4-methyl^ piperazine-1 -sulfonyl) -phenyl] -acetamide; 2-[3-(3-Chloro-5-cyano-pheno:xy)-4-methyl-phe^^^^ 4-sulfonyl)-phenyl] -acetamide; 2- [3-(3-Chloro-5-cyano-phenoxy)-4-methyl-phenyl] -N- [2-methyl-4-(2-morpholin-4-yl- ethylsulfamoyl)-phenyl] -acetamide; 2-[3-(3-Chloro-5-q^ano-phenoxy)-4-methyl-phenyl]-N-[4-(3-hydrory- propylsulfamoyl)-2-methyl-phenyl]-acetamide; 2-[4-Chloro-3-(3-cyano-5-1xifluoromethyl-phenoxy)-2-fluoro-phenyl]-N-(2-methyl-4- sulfamoyl-phenyl)-acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)«4-methyl-phenyl]-N-[4-(4-hydroxy- q^clohexylsxilfamoyl)-2-methyl-phenyl]-acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)-4-methyl-phenyl]-N-(2-methyl-4-sulfamoyl-phenyl)- acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)-4-methyl-phenyI]-N-(2-chloro«4-sulfamoyl-phenyl)- acetamide; 2- [4-Chloro-3-(4-cyano-6-methyl-pyridin-2-yloxy)-2-fluoro-phenyl] -N-(2-methyl-4- sulfamoyl-phenyl)-acetamide; 3-(4-{2-[3-(3-Chloro-5-cyano-phenoxy)-4-methyl-phenyl]-acetylamino}-3-methyl- benzenesulfonyl)-propionic acid; 2-[4-Chloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-chloro-4- propionylsulfamoyl-phenyl)-acetamide; sodium salt; N-[4-((S)-2-Amino-3-methyl-butyiylsdfamoyl)-2-chloro-phenyl]-2-[4-chloro-3-(3- chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-acetamide; sodium salt; 2- [3-(3-Chloro-5-cyano-phenoxy)-4-methyl-phenyl] -N- [2-methyl-4-(tetrahydro-pyran« 4-ylsulfamoyi)-phenyl] -acetamide; 2-[3-(3-Chloro-5-qrano-phenoxy)-4-methyl-phenyl]-N-[4-(2-hydroxy- propylsrdfamoyl)-2-methyl-phenyl]-acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)-4-methyl-phenyl]-N-[2-methyl-4-(2-methylsulfanyl- ethylsulfamoyl)-phenyl] -acetamide; 2-[3-(3-CHoro-5-cyano-phenoxy)-4-methyl-phenyl]-N-[2-methyl-4-(3-met±Lylsulfanyl- propylsulfamoyl)-phenyl]-acetamide; 2-[3-(3"CMoro-5-cyano-phenoxy)-5-methoxy--phenyl]-N-(4-sulfamoyl-phenyI)-acetamide; 2-[3-(3-CMoro-5-cyano-phenoxy)-5-medio^ phenyl)-acetamide; N-(2-ChlorO"4-sdfamoyl-phenyl)-2-[4,5-dibromo-3-(3"q^ano-5-difluoromethyl-phenoxy)-2-fluoro-phenyl] -acetamide; 2-[4-Chloro-3-(4-q^ano-2,6-dimethyl-phenoxy)-phenyl]-N-(2-Chloro«4-sulfamoyl« phenyl)-acetamide; 2-[3-(3-CMoro-5-cyano-phenoxy)-5-meth^^ phenyl)-acetamide; 2-[3-(3»Chloro-5-q^ano-phenoxy)-4-methyl-phenyl]*N-[4-(2-qrano-ethanesulfonyl)-2" methyl-phenyl] -acetamide; N-(4-Butyrylsulfamoyl-2-cHoro-ph^ fluoro-phenyl]-acetamide; sodium salt; N-[4-(Butyryl-methyl-sulfamoyl)"2-Chloro-phenyl]-2-[4-Chloro-3-(3-Chloro-5-q?rano-phenoxy)-2-fluoro-phenyl]-acetamide; N-(2-Chloro-4-sulfamoyl-phenyl)-2-[3-(3-cyano-5-difluoromethyl-phenoxy)-4-etiiyl- phenyl] - acetamide; 2-[3-(3-Chloro-5-q^ano-phenoxy)-5-metliyl-phenyl]-N-(4-sulfamoyl"plieiiyl)- acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)-5-metiiyl-phenyl]-N-(2-methyl-4-sulfamoyl-phenyl)- acetamide; 2-[3-(3-CHoro-5-cyano-phenoxy)-5-methyl^^ acetamide; 2-[7-(3-Cyano-phenoxy)-benzofuran-5-yl]-N-(4-sulfamoyl-phenyl)-acetamide; 2-[7-(3-Cyano-phenoxy)-benzofuran-5-yl]-N-(2-methyl-4-sulfamoyl-phenyl)- acetamide; 2-[3-(2-Chloro-5-cyano-phenoxy)-5-methyl-phenyl]-N-(4-sulfamoyl-phenyl)- acetamide; 2-[3-(2-Chloro-5-cyano-phenoxy)-5-methy^ acetamide; 2-[3-(2-Chloro-5-cyano-phenoxy)-5-m acetamide; N-(2-Chloro-4-sidfamoyi-phenyl)-2-[7-(3,5-diChloro-phenoxy)-benzoftu'an-5-yl] acetamide; 2-[3-(3-Chloro-5--cyano-phenoxy)'-4-methyl-phenyl]-N-[4-((S)-253-diliydroxy- propoxy)-2-meliiyI-phenyI]-acetamide; 2-[3-(3-CHoro-5-cyano-phenoxy)-4-methyl^ 2-methyl-phenyl] -acetamide; (4-{2-[3-(3-CHoro-5-cyano-phenoxy)-4^ benzenesulfonyl)-acetic acid; N-[4-(3-Amino-propionylsulfamoyl)-2-c^^ cyano-phenoxy)-2-fluoro-phenyl]-acetamide; compound with hydrochloric acid; N-[4-(2-Amino-ethanesdfonyl)-2-methyl-ph^ methyl-phenyl] -acetamide; 2-[4-Chloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-[2-chloro-4-(2-methoxy-acetylsulfamoyl)-phenyl] -acetamide; sodium salt; 2-[4-Chloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-[2-chloro-4-(2- hydroxy-acetylsulfamoyl)-phenyl]-acetamide; sodium salt; 2-[3-(3-Chloro-5-cyano-phenoxy)-4-methyl-phenyl]-N-[4-(3-hydroxy-propane-1- sulfonyl) -2-methyl-phenyl] -acetamide; 2- [3-(3-Chloro-5-cyano-phenoxy)-4-methyl-phenyl] -N-[4-( l,l-dioxo-lX6- [1,2] thiazinan-2-yl)-2-methyl-phenyl] -acetamide; 2- [3-(3-Chloro-5-cyano-phenoxy)-4-methyl-phenyl] -N-{2-methyl-4- [2-(4-methyl- piperazin-1 -yi) -acetyl] -phenyl} -acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)-4-methyl-phenyl]-N-[2-methyl-4-(l-oxo-lX4- thiomorpholin-4-yl)-phenyl] -acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)-4-methyl-phenyl]-N-[4-(l,l-dioxo-lX6- thiomorpholin-4-yl)-2-methyl-phenyl]-acetamide; 2-[4-Chloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-[2-chloro-4-(methyl- propionyl-sulfamoyl)-phenyl]-acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)-4-methyl-phenyl]-N-[2-met±iyl-4-(2-morpholm-4-yl- acetyl) -phenyl] -acetamide; compound with trifluoro-acetic acid; 2-[4-Chloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-[2-chloro-4-(3- methoxy-propionylsulfamoyl)-phenyl]-acetamide; sodium salt; 2-[4-Bromo-3-(3-cyano-5-difluoromethyl-phenoxy)-2-fluoro-phenyl]-N-(2-chloro-4- sulfamoyl-phenyl)-acetamide; 2-[4-Chloro-3-(3-cyano-5-difluoromethoxy-phenoxy)-2-fluoro-phenyl]-N-(4- sulfamoyl-phenyl)-acetamide; 2-[4-Chloro-3-(3-cyano-5-difluoromethoxy-phenoxy)-2-fluoro-phenyl]-N-(2-chloro-4- sulfamoyl-phenyl)-acetamide; 2-[4-Chloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-chloro-4- methylsulfamoyl-phenyl)-acetamide; 2-[4-Bromo-3-(3-cyano-5-difluoromethyl-phenoxy)-2-fluoro-phenyl]-N-(2-methyl-4- sulfamoyl-phenyl)-acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)-4-methyl-phenyl]-N-[4-(l,l-dioxo-lX6- isothiazolidin-2-yl) -2-methyl-phenyl] -acetamide; 2-[4-Chloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-{2-chloro-4-[(2- methoxy-acetyl)-meth7l-sulfamoyl]-phenyl}-acetainide; 2-[4-Chloro-3-(3-chloro-5-cyano-phenoxy-)-2-fluoro-phenyl]-N-{2-chloro-4-[(3-metiioxy-propionyl)-meliiyl-sulfamoyl]-phenyl}-acetamide; 2-[4-Qiloro-3-(3-Chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-cMoro-4-pentanoylsulfamoyl-phenyl)-acetamide; sodium salt; 2-[4-CHoro-3-(3-chloro-5-cyano^ butyrylsulfamoyI)-phenyl]-acetamide; sodium salt; 2-[4-Chloro-3-(3-Chloro-5-cyano-phenoxy)-2-fiuoro-phenyi]-N-[2-chloro--4-(2- diethylamino-acetylsulfamoyl)-phenyl]-acetamide; compound with hydrochloric acid; 2-[4-Chloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-[2-chloro-4-(4-methyl- pentanoylsulfamoyl)-phenyl]-acetamide; sodium salt; 2-[4-Chloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-[2-chloro-4-(2- morpholin-4-yl-acetylsirifamoyl)~phenyl] -acetamide; compound with hydrochloric acid; N-(4-{2-[3-(3-CMoro-5-c^ano-phenoxy)^-methyl-phenyl]-acetylamino}--3"methyl- phenyl)-oxalamic acid ethyl ester; N-(2-Chloro-4~sulfamoyl-phenyl)-2-[3-(3-c^ fluoro-phenyl] -acetamide; 2-[3-(3-Cyano-5-difluoromethyl-phenoxy)^ sulfamoyi-phenyl)-acetamide; N«{4-[(3-Amino-propionyl)-meliyl-sulfamoyl]-2-chloro-phenyl}-2-[4-chloro-3»(3- chloro»5-cyano«phenoxy)-2-fluoro-phenyl]-acetamide; compound with hydrochloric acid; 2-[3-(3-Chloro-5-cyano-phenoxy)-4J5-dimethyl-phenyl]-N-(4-sulfamoyl-phenyl)- acetamide; 2-[3-(3-Chloro-5-cyano-pheno:xy)-4,5- phenyl)-acetamide; 2-[3-(3 phenyl) -acetamide; 2-[3-(3-Bromo-5-cyano-phenoxy)-4-chloro-2-fluoro-phenyl]-N-(2-methyl-4-sulfamoyl- phenyl)-acetamide; 2-{4-Chloro-3- [3-cyano-5-(3-hydroxy-prop-1 -ynyl)-phenoxy] -2-fluoro-phenyl} -N-(2- methyl-4-sulfamoyl-phenyl)-acetamide; 2-{4-CHoro-3-[3-cyano-5-(3-dimethylamin^ N-(2-methyl-4-sulfamoyl-phenyl)-acetamide; 4-(3-Chloro-4-{2-[4-chloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]- acetylamino}-benzenesulfonylamino)-4-oxo-butyricacid; 2-[4-Bromo-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-methyl-4-sulfamoyl- phenyl)-acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)-2-fluoro-4-methoxy-phenyl]-N-(2-chloro-4- sulfamoyl-phenyl)-acetamide; 2-[3-(3-CMoro-5-cyano-phenox^ sulfamoyl-phenyl)-acetamide; or 2-[4-Chloro-3-(3-chloro-phenoxy)-phenyl]-N-phenyl-acetamide, 11. Compound of formula la according to claim 9, which is 2-[4-CHoro-3-(3-chloro-5-cyano-phenoxy)-2'fluoro-phenyl]-N-(2-Chloro»4-sulfamoyl-phenyl)-acetamide; 2-[4-Qiloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-chloro-4-propionylsulfamoyl-phenyl)-acetamide; sodium salt; 2-[3-(3-Chloro-5-cyano-phenoxy)-2-fluoro-4-methyl-phenyl]-N-(2-chloro-4-siilfamoyl- phenyl)-acetamide; 2-[4-Bromo-3-(3-cMoro-5-cyano-pheno;^)^ phenyl)-acetamide; 2-[4-Bromo-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-chloro-4- propionylsulfamoyl-phenyl)-acetamide; sodium salt, N-(4-Butyrylsulfamoyl-2-chloro-pheny^^ fluoro-phenyl]-acetamide; sodium salt; N-[4-((S)-2-Amino-3-methyl-but^ chloro-5-cyano-phenoxy)-2-fluoro-phenyi]-acetamide; sodium salt; N-(2-Chloro-4-sxilfamoyl-phenyl)-2-[3-(3-cyano-5-difiuoromethyl-phenoxy)-4-ethyl-2- fluoro-phenyl] -acetamide; 2-[3-(3-Cyano-5~difluoromethyl-phen^ sulfamoyl-phenyl)-acetamide; 2-[4-Bromo-3-(3-Chloro-5-cyano»phenoxy)-2-fluoro»phenyl]-N-(2-methyl-4-sulfamoyl- phenyl)-acetamide; 2-[4-Bromo-3-(3-cyano-5-difluoromethyl-phenoxy)-2-fluoro-phenyl]-N-(2-methyl-4- sulfamoyl-phenyl)-acetamide; 2-[4-Bromo-3-(3-cyano-5-difluoromethyl-phenoxy)-2-£luoro-phenyl]-N-(2-chIoro-4- sulfamoyl-phenyl)-acetamide; 2-[4-CHoro-3-(3-cyano-5-difluoromethyl-phenoxy)-2-fluoro-phenyl]-N-(2-methyl-4- sdfamoyl-phenyl)-acetamide; 2-[3-(3-Chloro-5-cyano-phenoxy)-2-fluoro-4-methoxy-phenyl]-N-(2-chloro-4- sulfamoyl-phenyl)-acetamide; 2-[3-(3-CMoro-5-cyano--phenoxy)-2-fluoro-4-methoxy-phenyl]-N-(2-methyl-4- sulfamoyl-phenyl)-acetamide; and, 2-[3-(3-Chloro-5-cyano-phenoxy)-2-fluoro-4-methyl-phenyl]-N"(2«chloro-4- propionylsulfamoyl-phenyl)-acetamide; sodium salt 12. Compound of formula la according to any one of claims 7 to 11 for use as medicament 13. Use of the compound of formula la according to any one of claims 7 to 11 for the manufacture of a medicament for the treatment of diseases mediated by the human immunodeficiency virus (HIV) 14. A pharmaceutical composition comprising a pharmaceutically effective amount of compound or a pharmaceutically acceptable salt thereof as defined in any one of claim 1 to 11 and a pharmaceutical inert carrier. 15. A pharmaceutical composition according to claim 14 for the use in the treatment of diseases mediated by the human immunodeficiency virus (HIV). 16. The invention as hereinbefore described.

Documents:

3889-CHENP-2006 AMENDED PAGES OF SPECIFICATION 06-09-2012.pdf

3889-CHENP-2006 AMENDED CLAIMS 06-09-2012.pdf

3889-CHENP-2006 CORRESPONDENCE OTHERS. 05-12-2013.pdf

3889-CHENP-2006 FORM-3 05-12-2013.pdf

3889-CHENP-2006 FORM-3 06-09-2012.pdf

3889-CHENP-2006 OTHER PATENT DOCUMENT 06-09-2012.pdf

3889-CHENP-2006 AMENDED CLAIMS 07-10-2014.pdf

3889-CHENP-2006 CORRESPONDENCE OTHERS 08-09-2014.pdf

3889-CHENP-2006 CORRESPONDENCE OTHERS 15-05-2013.pdf

3889-CHENP-2006 EXAMINATION REPORT REPLY RECEIVED 06-09-2012.pdf

3889-CHENP-2006 FORM-3 15-05-2013.pdf

3889-CHENP-2006 POWER OF ATTORNEY 06-09-2012.pdf

3889-CHENP-2006 CORRESPONDENCE OTHERS 02-01-2012.pdf

3889-CHENP-2006 CORRESPONDENCE OTHERS 11-06-2014.pdf

3889-CHENP-2006 CORRESPONDENCE OTHRES 19-09-2014.pdf

3889-CHENP-2006 EXAMINATION REPORT REPLY RECIEVED 07-10-2014.pdf

3889-CHENP-2006 FORM-3 11-06-2014.pdf

3889-CHENP-2006 OTHER PATENT DOCUMENT 05-12-2013.pdf

3889-CHENP-2006 OTHERS 05-12-2013.pdf

3889-chenp-2006-abstract.pdf

3889-chenp-2006-assignement.pdf

3889-chenp-2006-claims.pdf

3889-chenp-2006-correspondnece-others.pdf

3889-chenp-2006-description(complete).pdf

3889-chenp-2006-form 1.pdf

3889-chenp-2006-form 26.pdf

3889-chenp-2006-form 3.pdf

3889-chenp-2006-form 5.pdf

3889-chenp-2006-pct.pdf