Title of Invention	OXAZOLE DERIVATIVES OF TETRACYCLINES
Abstract	This invention provides compounds of the formula: wherein A", X and Y are defined in the specification. These compounds are useful as antibacterial agents.

Full Text

WO 2005/056538 PCT/US2004/040850 OXAZOLE DERIVATIVES OF TETRACYCLINES FIELD OF THE INVENTION The present invention relates to novel oxazole derivatives of tetracyclines which are useful as antibiotic agents and exhibit antibacterial activity against a wide spectrum of organisms including organisms which are resistant to tetracyclines and other antibiotics. This invention also relates to novel tetracycline intermediates useful for making the novel compounds and novel methods for producing the novel compounds and the intermediate compounds. BACKGROUND OF THE INVENTION Since 1947 a variety of tetracycline antibiotics have been synthesized and described for the treatment of infectious diseases in man and animals. Tetracyclines inhibit protein synthesis by binding to the 30S subunit of the bacterial ribosome preventing binding of aminoacyl RNA (Chopra, Handbook of Experimental Pharmacology, Vol. .78, 317-392, Springer-Verlag, 1985). Resistance to tetracyclines has emerged among many clinically important microorganisms which limit the utility of these antibiotics. There are two major mechanisms of bacterial resistance to tetracyclines: a) energy-dependent efflux of the antibiotic mediated by proteins located in the cytoplasmic membrane which prevents intracellular accumulation of tetracycline (S. B. Levy, et al., Antimicrob. Agents Chemotherapy 33, 1373-1374 (1989); and b) ribosomaj protection mediated by a cytoplasmic protein which interacts with the ribosome such that tetracycline no longer binds or inhibits protein synthesis (A. A. Salyers, B. S. Speers and N. B. Shoemaker, Mol. Microbiol, 4:151-156,1990). The efflux mechanism of resistance is encoded by resistance determinants designated tetA-tetL. They are common in many Gram-negative bacteria (resistance genes Class A-E), such as Enterobacteriaceae, Pseudomonas, Haemophilus and Aeromonas, and in Gram- positive bacteria (resistance genes Class K and L), such as Staphylococcus, Bacillus and Streptococcus. The ribosomal protection mechanism of resistance is encoded by resistance determinants designated TetM, N and O, and is common in Staphylococcus, Streptococcus, Campylobacter, WO 2005/056538 PCT/US2004/040850 Gardnerella, Haemophilus and Mycoplasma (A. A. Salyers, B. S. Speers and N. B. Shoemaker, Mol. Microbiol, 4:151-156 1990). A particularly useful tetracycline compound is 7-(dimethylamino)- 6-demethyl-6-deoxytetracycline, known as minocycline (see U.S. Pat. No. 3,148,212, U.S. Pat. No. RE 26,253 and U.S. Pat. No. 3,226,436 discussed below). However, strains, harboring the tetB (efflux in gram-negative bacteria) mechanism, but not tetK (efflux in Staphylococcus) are resistant to minocycline. Also, strains carrying tetM (ribosomal protection) are resistant to minocycline. This invention describes the synthesis of novel tetracycline compounds which demonstrate significant in vitro and in vivo activity vs. tetracycline and minocycline susceptible strains and some tetracycline and minocycline resistant strains, that is, those harboring the tetM (ribosomal protection) resistance determinants. Duggar, U.S. Pat. No. 2,482,055, discloses the preparation of Aureomycin.RTM. by fermentation which have antibacterial activity. Growich et al., U.S. Pat. No. 3,007,965, disclose improvements to the fermentation preparation. Beereboom et al., U.S. Pat. No. 3,043,875 discloses tetracycline derivatives Boothe et al., U.S. Pat. No. 3,148,212, reissued as U.S. Pat. No. RE 26,253, and Petisi et al., U.S. Pat. No. 3,226,436, discloses tetracycline derivatives which are useful for treating bacterial infections. Blackwood et al., U.S. Pat. No. 3, 200,149 discloses tetracycline derivatives which possess microbiological activity. Petisi et al., U.S. Pat. No. 3,338,963 discloses tetracycline compounds which have broad-spectrum antibacterial activity. Bitha et al., U.S. Pat. No. 3,341,585 discloses tetracycline compounds which have broad-spectrum antibacterial activity. Shu, U.S. Pat. No. 3,360,557 discloses 9- hydroxytetracyclines which have been found to possess antibacterial activity. Zambrano, U.S. Pat. No. 3,360,561 discloses a process for preparing 9-nitrotetracyclines. Martell et al., U.S. Pat. No. 3,518,306 discloses tetracyclines which possess in vivo antibacterial activity. In U.S. Pat. No. 5,021,407 a method of overcoming the resistance of tetracycline resistant bacteria is disclosed. The method involves utilizing a blocking agent compound in conjunction with a tetracycline type antibiotic. This patent does not disclose novel tetracycline compounds which themselves have activity against resistant organisms. Described in U.S. Pat. No. 5,494,903 are 7-substituted-9- 2 WO 2005/056538 PCT/US2004/040850 substitutedamino-6-demethyl-6-deoxytetracyclines which have broad spectrum antibacterial activity. In summary, none of the above patents teach or suggest the novel compounds of this application. In addition, none of the above patents teach or suggest novel tetracycline compounds of the invention having activity against tetracycline and minocycline * resistant strains as well as strains which are normally susceptible to tetracyclines. SUMMARY OF THE INVENTION In accordance with the present invention, there is provided compounds represented by Formula (I); wherein: X is selected from hydrogen, amino, NR11R12, alky! of 1 to 12 carbon atoms optionally substituted , aryl of 6,10 or 14 carbon atoms optionally substituted, vinyl optionally substituted, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; A" is a moiety selected from the group: R11 and R12 are each independently H or alkyl of 1 to 12 carbon atoms or 3 WO 2005/056538 PCT/US2004/040850 R11 and R12 when optionally taken together with the nitrogen atom to which each is attached form a 3 to 7 membered saturated hydrocarbon ring; Y is selected from hydrogen, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6, 10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, vinyl, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; R is selected from alkyl of 1 to 12 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, alkynyl of 2 to 12 carbon atoms optionally substituted, -CH2NR1R2, aryl of 6,10 or 14 carbon atoms optionally substituted, aralkyl of 7 to 16 carbon atoms optionally substituted, aroyl of 7 to 13 carbon atoms optionally substituted, SR3, heteroaryl of 5 or 6 ring atoms optionally substituted, containing 1 to 4 heteroatoms which may be the same or different, independently selected from nitrogen, oxygen and sulfur, and heteroarylcarbonyl of 5 or 6 ring atoms optionally substituted containing 1 to 4 heteroatoms which may be the same or different, independently selected from nitrogen, oxygen and sulfur; R1 and Rz are each independently H or alkyl of 1 to 12 carbon atoms or R1 and R2 when optionally taken together with the nitrogen atom to which each is attached form a 3 to 7 membered saturated hydrocarbon ring; R3 is alkyl of 1 to 12 carbon atoms optionally substituted, -CH2-aryl optionally substituted, aralkyl of 7 to 16 carbon atoms optionally substituted, aroyl, -CH2(CO)0CH2aryl optionally substituted, -CH2-alkenyl of 2 to 12 carbon atoms optionally substituted, and -CH2-alkynyl of 2 to 12 carbon atoms optionally substituted; with the provisos that when X is NR1R2 and R1 is hydrogen, then R2 is methyl, ethyl, n-propyl, n-butyl, 1-methylethyl, 1 -methylpropyl, 2-methylpropyl or 1,1-dimethylethyl; and that when R1 is methyl or ethyl then R2 is methyl, ethyl, n-propyl, 1-methylethyl, n-propyl, 1-methylpropyl, or 2-methylpropyl; or a tautomer or pharmaceutically acceptable salts thereof. 4 WO 2005/056538 PCT/US2004/040850 Definitions The term alkyl as a group or part of a group means a straight or branched alkyl moiety of 1 to 12 carbon atoms which can be optionally independently substituted with 1 to 3 substituents selected from the group halogen, amino, cyano, cycloalkyl of 3 to 6 carbon atoms, alkyl of 1 to 12 carbon atoms, aryl optionally substituted, phenyl, hydroxyl, alkoxy of 1 to 12 carbon atoms, NH-alkyl of 1 to 12 carbon atoms, N-cycloalkyl of 3 to 6 carbon atoms, NH-(alkyl of 1 to 12 carbon atoms)-aryl optionally substituted and heterocyclyl of 3 to 8 membered ring. In some embodiments of the invention alkyl is a moiety of 1 to 6 carbon atoms. In other embodiments of the invention alkyl is a moiety of 1 to 3 carbon atoms. In other embodiments alkyl is substituted by heterocyclyl of 4 to 7 ring members (e.g. pyrrolidinyl) The term alkenyl means a straight or branched carbon chain of 2 to 12 carbon atoms having at least one site of unsaturation optionally independently substituted with 1 to 3 substituents selected from the group optionally substituted aryl, phenyl, heteroaryl, halogen, amino, cyano, alkyl of 1 to 12 carbon atoms, hydroxyl, and alkoxy of 1 to 12 carbon atoms. The term vinyl means a moiety CH2=CH-. As used herein the term alkoxy as a group or part of a group refers to alkyl-O-wherein alkyl is hereinbefore defined. As used herein the term aryl as a group or part of a group, e.g., aralkyl, aroyl, means an aromatic moiety having 6,10 or 14 carbon atoms preferably 6 to 10 carbon atoms, which can be optionally substituted with 1 to 3 substituents independently selected from halogen, nitro, cyano, alkenyl, hydroxyl, alkyl, haloalkyl, alkoxy, benzyloxy, amino, alkylamino, dialkylamino, carboxyl, alkoxycarbonyl, methylenedioxy and 5 WO 2005/056538 PCT/US2004/040850 phenyl. In particular, aryl is phenyl or naphthyl optionally substituted with 1 to 3 substituents. Substituted phenyl may optionally be the moiety The term aralkyl as used herein of 7 to 16 carbon atoms means an alkyl substituted with an aryl group in which the aryl and alkyl group are previously defined. Non-limiting exemplary aralkyl groups include benzyl and phenethyl and the like. Phenyl as used herein refers to a 6-membered carbon aromatic ring. As used herein the term alkynyl includes both straight chain and branched moieties containing 2 to 12 carbon atoms having at least one carbon to carbon triple bond optionally substituted with 1 to 3 substituents independently selected from the group halogen, amino, cyano, alkyl of 1 to 12 carbon atoms, hydroxyl, and alkoxy of 1 to 12 carbon atoms. As used herein the term halogen or halo means F, C\, Br or I. As used herein the term cycloalkyl means a saturated monocyclic ring having from 3 to 6 carbon atoms. Exemplary cycloalkyl rings include but are not limited to cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl. In an embodiment of the invention cycloalkyl is a moiety of 5 or 6 carbon atoms. As used herein, R1 and Rz and R11 and R12 when optionally taken together with the nitrogen atom to which each is attached form a 3 to 7 membered saturated hydrocarbon ring, where a non-limiting example is pyrrolidinyl, 6 WO 2005/056538 PCT/US2004/040850 The term aroyl means an aryl-C(O)- group in which the aryl group is as previously defined. Non-limiting examples include benzoyl and naphthoyl. The term heteroaryl means an aromatic heterocyclic, monocyclic ring of 5 or 6 ring atoms containing 1 to 4 heteroatoms independently selected from O, N and S. Heteroaryl rings may optionally be substituted with 1 to 3 substitutents selected from the group halogen, cyano, nitro, hydroxy, amino, alkylamino, dialkylarnino, alkoxy, aryloxy, -CH2OCOCH3 and carboxy. Non-limiting heteroaryl moieties optionally substituted include: furanyl, thienyl, pyridyl, tetrazolyl, imidazo, thiazolyl and the like. Further included are benzofuranyl, benzothienyl and quinolinyl. The term heteroarylcarbonyl means a heteroaryl-C(O)- group in which the heteroaryl group is as previously defined. s The term heterocyclyl as used herein represents a saturated 3 to 8 membered ring containing one to three heteroatoms selected from nitrogen, oxygen and sulfur. Representative examples are pyrrolidyl, piperidyl, piperazinyl, morpholinyl, thiomorpholinyl, aziridinyl, tetrahydrofuranyl and the like. The term alkylheterocyclyl means an alkyl-heterocyclyl group in which the alkyl and heterocyclyl group are previously defined. Non-limiting exemplary alkylheterocyclyl groups include moieties of the formulae: Some of the compounds of formula (I), may also exist in their tautomeric forms. Such forms although not explicitly indicated in the above formula are intended to be 7 WO 2005/056538 PCT/US2004/040850 included within the scope of the present invention. For instance, compounds of formula (I) which exist as tautomers are depicted bejow: One embodiment of this invention is where R of Formula (1) is selected from the group alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, and alkyl-(heterocyclyl) selected from moieties of the group Another embodiment of the invention is where R of Formula (I) is phenyl optionally substituted with 1 to 3 substituents. In a preferred embodiment R is selected from moieties of the group 8 9 WO 2005/056538 PCT/US2004/040850 WO 2005/056538 PCT/US2004/040850 A further preferred embodiment of the invention is where R is heteroaryl. In a preferred embodiment R is selected from moieties of the group An additional embodiment of the invention is where R is alkyl of 1 to 6 carbon atoms optionally substituted, alkenyl of 2 to 6 carbon atoms optionally substituted, 10 WO 2005/056538 PCT/US2004/040850 NH(cydoalkyl of 5 to 6 carbon atoms), NH(alkyl of 1 to 6 carbon atoms) and NH(alkyl of 1 to 6 carbon al:oms)-aryl optionally substituted. In a preferred embodiment R is selected from moieties of the group 11 WO 2005/056538 PCT/US2004/040850 An additional embodiment of the invention is where R of Formula (I) is S-alkyl of 1 to 12 carbon atoms, S-CH2-ary! optionally substituted and S-CH2(CO)OCH2aryl 12 WO 2005/056538 PCT/US2004/040850 optionally substituted. In a preferred embodiment R is selected from moieties of the group Preferred compounds of the invention include those selected from the group: (6aRI7aS,8S,11aS)-5,8-bis(dimethylamino)-2-(2,2-diphenylvinyl)-9,11a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-. carboxamide, (7aS,8S,11 aS)-8-(dimethylamino)-9,11 a,13-trihydroxy-2-(2-methyl-1 -propeny])-11,12-dioxo-7,7a,8,11,11 a,12-hexahydronaphthaceno[2,1 -d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S, 11 aS)-2-fert-butyl-5,8-bis(dimethylamino)-9,11 a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide, (6aR,7aS)85,11aS)-5,8-bis(dimethylamino)-2-[(£)-2-(2-furyl)ethenyl]-9,11a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11>11a,13-octahydrotetraceno[2,1-d]t1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11aS)-5,8-bis(dimethylamino)-9,11a,12-trihydroxy-11,13-dioxo-2-[(£)-2-phenylethenyl]-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide, 13 WO 2005/05653X PCT/US2004/040850 (6aR,7aS,8S,11aS)-5,8-bis(dimethylamino)-9,11a,12-trihydroxy-2-[(£)-2-(4-methoxyphenyl)ethenyl]-11,13-dioxo-6,6a,7,7a,8,11,11a,13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11aS)-5)8-bis(dimethylamino)-9,11a)12-trihydroxy-2-t(E)-2-(3-methoxyphenyl)ethenyl]-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide, (6aR,7aSl8SI11aS)-5,8-bis(dimethy!amino)-9>11a,12-trihydroxy-2-[(£)-2-(2-methoxyphenyl)ethenyl]-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11aS)-5,8-bis(dimethylamino)-2-[(E)-2-(4-fluorophenyl)ethenyl]-9,1 1a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11 aS)-5,8-bis(dimethylamino)-2-[(£)-2-(2-fluorophenyl)ethenyl]-9,11a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11 aS)-2-(chloromeihyl)-5,8-bis(dimethylarnino)-9,11 a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11 aS)-5,8-bis(dimethylamino)-2-[(dimethylamino)methyl]-9,11 a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11 aS)-5,8-bis(dimethylamino)-9,11 a, 12-trihydroxy-11,13-dioxo-2-(pyrro!idin-1-ylmethyl)-6,6a,7,7a,8,11,11a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide, 14 WO 2005/056538 PCT/US2004/040850 (6aR,7aS,8S,11 aS)-5)8-bis(dimethylamino)-9,11 a,12-trihydroxy-11,13-dioxo-2-[(propylaminoJmethyn-e.eaJJa.B.11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11aS)-2-[(butylamino)methyI]-5,8-bis(climethylamino)-9,11 a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide, (6aRJ7aS,8SI11aS)-5,8-bis(dimethylamino)-9,11aI12-trihydroxy-11,13-dioxo-2-[(propylamino)methyl]-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide and (6aR,7aS,8SI11aS)-2-[(ferf-butylamino)methyl]-5,8-bis(dimethylamino)-9,11a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide. Preferred compounds of the invention include those selected from the group: (7aS,8S,11aS)-8-(dimethyIamino)-2-[4-(dimethylamino)phenyl]-9,11a,13-trihydroxy-11,12-dioxo-7,7a,8,11,11a,12-hexahydronaphthaceno[2,1-d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11 aS)-2-fe/t-buty!-5,8-bis(dimethylamino)-9,11 a,12-trihydroxy-11,13-dioxo-G.eayja.S.11,11 a, 13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11aS)-5,8-bis(dimethylamino)-9I11a,12-trihydroxy-2-(4-methylphenyl)-11,13-dioxo-6,6a,7,7a,8,11,11 a, 13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide, (7aS,8S, 11 aS)-5,8-bis(dimethylamino)-2-(3-f luorophenyl)-9,11 a, 13-trihydroxy-11,12-dioxo-7,7a,8,11,11 a,12-hexahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide, 15 WO 2005/056538 PCT/US2004/040850 (6aR)7aS,8S,11aS)-2-(4-cyanophenyl)-5,8-bis(dimethylamino)-9,11a,12-trihydroxy- 11,13-dioxo-6,63,7,73,8,11,11a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10- carboxamide, (6aR,7aS,8S,11 aS)-5,8-bis(dimethylamino)-2~[4-(dimethylamino)phenyl]-9,11a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide, (6aR,7aSI8S,11aS)-2-(5-fert-butyl-2-hydroxyphenyl)-5,8-bis(dimethylamino)-9,11 a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11 aS)-2-[4-(benzy]oxy)phenyl]-5,8-bis(dimethylamino)-9,11 a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide, (6aR,7aS,85,11 aS)-2-(2,4-dihydroxyphenyl)-5,8-bis(dimethylamino)-9>11 a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11 aS)-5,8-bis(dimethylamino)-2-(3-fluoro-4-methoxyphenyl)-9,11 a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11aS)-2-(1l3-benzodioxol-5-yl)-5I8-bis(dimethylamino)-9,11a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide, (6aR,7aS>8S,11aS)-5,8-bis(dimethylamino)-9>11a,12-trihydroxy-11,13-dioxo-2-(2>4,6-irimethoxyphenyl)-6,6a,7,7a,8,11,11a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide, 16 WO 2005/056538 PCT/US2004/040850 (6aRl7aS,8S,11aS)-5,8-bis(dimethylamino)-9,11a,12-trihydroxy-11,13-dioxo-2-(Z^.S-triethoxyphenyO-e.ea.y.ya.S.II.Ha.iS-octahydrotetracenopji-dlfi.Sloxazole-10-carboxamide, (6aR,7aS,8S,11 aS)-5,8-bis(dimethylamino)-9,11 a,12-trihydroxy-2-(1 -methyl-1 H-indol-2-yl)-11,13-dioxo-6,6a,7,7a,8,11,11 a, 13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11 aS)-2-(4-fert-butylphenyl)-5,8-bis(dimethy!amino)-9,11 a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a, 13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide and (6aR,7aS,8S,11 aS)-5(8-bis(dimethylamino)-2-[4-(hexyloxy)phenyl]-9,11 a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide. Preferred compounds include those selected from the group: (6aR,7aS,8S,11aS)-5,8-bis(dimethylamino)-9,11a,12-trihydroxy-11,13-dioxo-2-thien-3-yl-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11 aS)-2-(1 -benzofuran-2-yl)-5,8-bis(dimethylamino)-9,11 a,12-¦ trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a, 13-octahydrqtetraceno[2,1 -d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11aS)-5,8-bis(dimethylamino)-2-(2-furyl)-9,11 a,12-trihydroxy-11,13-dioxo-S.eaJJaAl 1,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide, {5-[(6aR,7aS,8S, 11 aS)-10-(aminocarbonyl)-5,8-bis(dimethylamino)-9,11 a, 12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetracenoI2,1 -d][1,3]oxazol-2-yl]-2-furyl}methyl acetate, (6aR,7aS,8S, 11 aS)-2-(1 -benzothien-3-yl)-5,8-bis(dimethylamino)-9,11 a, 12- 17 WO 2005/056538 PCT/US2OO4/O4O850 trihydroxy-11,13-dioxo-6,6a,7I7a,8,11,11a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11 aS)-5,8-bis(dimethylamino)-9,11 a,12-trihydroxy-11,13-dioxo-2-(1,3-thiazol-2-y))-6,6a,7,7a,8,11,11a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11 aS)-5,8-bis(dimethylamino)-9,11 a,12-trihydroxy-11,13-dioxo-2-pyridin^-yl-S.eaJJa.S.11,11 a,13-octahydrotetracenot2,1-d][i ,3]oxazole-10-carboxamide and (6aR,7aS,8S,11aS)-5,8-bis(dimethy]amino)-9,11a,12-trihydroxy-11,13-dioxo-2-pyridin-3-yl~6,6a,7,7a,8,11,11 a, 13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide. An additional embodiment of the invention is a process for the preparation of a compound of the formula or a pharmaceutically acceptable salt thereof wherein: X is selected from hydrogen, amino, NR1R2, alkyl of 1 to 12 carbon atoms optionally substituted., aryl of 6,10 or 14 carbon atoms optionally substituted, vinyl optionally substituted, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; R1 and R2 are each independently H or alkyl of 1 to 12 carbon atoms or 18 WO 2005/056538 PCT/US2004/040850 R1 and R2 when optionally taken together with the nitrogen atom to which each is attached form a 3 to 7 membered saturated hydrocarbon ring; Y is selected from hydrogen, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6,10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, vinyl, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; comprising the steps: a. reacting 7-(substituted)-8-(substituted)-9-arnino-6-demethyl-6-deoxytetracycline of the formula or a pharmaceutically acceptable salt thereof with 2-chlorotrimethoxyethane in an aprotic solvent to afford a chloro compound of the formula b. reacting the chloro compound with an amine R1R2NH to form a substituted amine of the formula 19 WO 2005/056538 PCT/US2004/040850 c. hydrolyzing the substituted amine with acid to give a compound of the formula d. isolating the compound or a pharmaceutjcally acceptable salt thereof. In a preferred embodiment of the process X is N(CH3)2and the amine R1R2NH is t-butyl amine. In a preferred embodiment of the process the compound [4S-(4a,4aa,5aa,12acc)]-4,7-Bis(dirnethylamino)-9-[2-(1,1 -dimethylethy!amino)acetylamino]-1,4,43,5,58,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide or a pharmaceutically acceptable salt thereof is prepared. A further embodiment of the invention is a process for the preparation of a - compound of the formula 20 WO 2005/056538 PCT/US2004/040850 wherein: X is selected from hydrogen, amino, NR1R2, alkyl of 1 to 12 carbon atoms optionally substituted , aryl of 6,10 or 14 carbon atoms optionally substituted, vinyl, optionally . substituted, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; R1 and R2 are each independently H or alkyl of 1 to 12 carbon atoms or R1 and R2 when optionally taken together with the nitrogen atom to which each is attached form a 3 to 7 membered saturated hydrocarbon ring; Y is selected from hydrogen, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6,10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, vinyl, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; or a pharmaceutically acceptable salt thereof comprising the steps: a. reacting 7-(substituted)-8-(substituted)-9-amino-6-demethyl-6-deoxytetracycline of the formula or a pharmaceutically acceptable salt thereof with 2-chlorotrimethoxyethane in an aprotic solvent to afford a chloro compound of the formula 21 WO 2005/056538 PCT/US2004/040850 b. reacting the chloro compound with acid to give 9-(2- chloromethylcarbonylamino)substituted-6-demethyl-6-deoxytetracyclineof the formula c. reacting the 9-(2-chloromethylcarbonylamino)substituted-6-demethy!-6- deoxytetracycline with amine R1R2NH to give a compound of the formula and d. isolating the compound or a pharmaceutically acceptable salt thereof. In a preferred embodiment of the process X is N(CH3)2and the amine R1R2NH is t-butyl amine. In a preferred embodiment of the process the compound [4S-(4a,4aa,5aa,12aa)]-4,7-Bis(dimethylamino)-9-[2-(1,1-dimethylethylamino)acetylamino]- 22 WO 2005/056538 PCT/US2004/040850 1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11 -dioxo-2-naphthacenecarboxamide or a pharmaceutically acceptable salt thereof is prepared. An additional embodiment of the invention is a compound of the formula or a pharmaceutically acceptable salt thereof wherein: X is selected from hydrogen, amino, NR1R2, alkyl of 1 to 12 carbon atoms optionally substituted , aryl of 6, 10 or 14 carbon atoms optionally substituted, vinyl optionally substituted, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; R1 and R2are each independently H or alkyl of 1 to 12 carbon atoms or R1 and R2 when optionally taken together with the nitrogen atom to which each is attached form a 3 to 7 membered saturated hydrocarbon ring; Y is selected from hydrogen, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6,10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, vinyl, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; produced by the process comprising the steps: a. reacting 7-(substftuted)-8-(substituted)-9-amino-6-demethyl-6-deoxytetracycline of the formula 23 WO 2005/056538 PCT/US2004/O4O850 or a pharmaceutically acceptable salt thereof with 2-chlorotrimethoxyethane in an aprotic solvent to afford a chloro compound of the formula b. reacting the chloro compound with an amine R1RZNH to form a substituted amine of the formula c. hydrolyzing the substituted amine with acid to give a compound of the formula 24 WO 2005/056538 PCT/US2004/040850 d. isolating the compound or a pharmaceutically acceptable salt thereof. In a preferred embodiment of the process X is N(CH3)2and the amine R1R2NH is t-butyl amine. In a preferred embodiment of the process the compound [4S-(4a,4aa,5aa,12aa)]-4,7-Bis(dimethylamino)-9-[2-(1,1-dimethylethylamino)acetylamino]-1,4,43,5,58,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide or a pharmaceutically acceptable salt thereof is prepared. In an additional embodiment of the invention a compound of the formula wherein: X is selected from hydrogen, amino, NR1R2, alky! of 1 to 12 carbon atoms optionally substituted , aryl of 6,10 or 14 carbon atoms optionally substituted, vinyl optionally substituted, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; R1 and R2 are each independently H or alkyl of 1 to 12 carbon atoms or when optionally taken together with the nitrogen atom to which each is attached form a 3 to 7 membered saturated hydrocarbon ring; Y is selected from hydrogen, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6,10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms 25 WO 2005/056538 PCT/US2004/040850 optionally substituted, vinyl, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; or a pharmaceutically acceptable salt thereof produced by the process comprising the steps: a. reacting 7-(substituted)-8-(substituted)-9-amino-6-demethyl-6-deoxytetracycline of the formula or a pharmaceutically acceptable salt thereof with 2-chlorotrimethoxyethane in an aprotic solvent to afford a chloro compound of the formula b. reacting the chloro compound with acid to give 9-(2- chloromethylcarbonyiamino)subst'rtuted-6-dernethyl-6-deoxytetracyclineof the formula c. reacting the 9-(2-chiorornethylcarbonylamino)substituted-6-demethyl-6- deoxytetracycline with amine R1R2NH to give a compound of the formula 26 WO 2005/056538 PCT/US2004/040850 d. isolating the compound or a pharmaceutically acceptable salt thereof. In a preferred embodiment of the process X is N(CH3)2and the amine R1R2NH is t-butyl amine. In a preferred embodiment the compound [4S-(4a,4aa,5aa,12aa)]-4,7-Bis(dimethylamino)-9-[2-(1,1-dimethylethylamino)acetylamino]-1,4,43,5,58,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide or a pharmaceutically acceptable salt thereof is prepared by the process. 27 WO 2005/056538 PCT/US2004/040850 DESCRIPTION OF THE PREFERRED EMBODIMENTS The novel compounds of the present invention may be readily prepared in accordance with the following Scheme I. The starting 7-(substituted)-8-(substituted)-9-amino-6-demethyl-6-deoxytetracyclines 1 or pharmaceutically acceptable salts thereof where X and Y are hereinbefore defined are reacted with aldehyde RCHO in the presence of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) to afford benzoxazole 2 and 3 (Procedure A). As further described, reaction of 7-(substituted)-8-(substituted)-9-amino-6-demethyl-6-deoxytetracyclines 1 or pharmaceutically acceptable salts thereof where X and Y are hereinbefore defined are reacted with 2-chloro-1,1,1-trimethoxy-ethane in an aprotic solvent such as N,N-dimethylformamide (DMF) to give chloromethyl-benzoxazole 4 , optionally isolated, then converted to substituted amine 5 by further reaction with an amine 9 (Procedure B). Hydrolysis of amine 5 affords 9-(2-substituted aminomethyl carbonylamino)substituted-6-dimethyl-6-deoxytetracycline 6 (Procedure D). Hydrolysis of chloromethylbenzoxazole 4 gives 9-(2-chloromethylcarbonyI-amino)substituted-6-demethyl-6-deoxytetracycline 7 which may be further reacted with amine 9 to give 9-(2-substituted aminomethyl carbonylamino)substituted-6-dimethyI-6-deoxytetracycline 6. Additionally, reaction of 7-(substituted)-8-(substituted)-9-amino-6-demethyl-6-deoxytetracyclines 1 or pharmaceutically acceptable salts thereof with thiocarbonyldiimidazole provides thio 8 followed by alkylation with RCH2Br in the presence of an amine which includes N,N-diisopropylethylamine affords oxazole 10 (Procedure C). Preferably, amine 9 in the preparation of 9-(2-substituted aminomethyl carbonylamino)substituted-6-dimethyl-6-deoxytetracycline 6, in Scheme I is t-butylamine. 28 29 WO 2005/056538 PCT/US2004/040850 WO 2005/056538 PCT/US2004/040850 As shown in Scheme II, the starting 7-(substituted)-8-(substituted)-9-amino-6-demethyl-6-deoxytetracyclines 1 or pharmaceutically acceptable salts thereof where X and Y are hereinbefore defined are reacted with a methyl orthoester to afford methyl benzoxazole derivative 11. Acid hydrolysis of methyl benzoxazole derivative 11 affords M-acetyl derivative 12. 30 WO 2005/056538 PCT/US2004/040850 Reactions are performed in a solvent appropriate to the reagents and materials employed and suitable for the transformation being effected. It is understood by those skilled in the art of organic synthesis that the various functionalities present on the molecule must be consistent with the chemical transformations proposed. This may necessitate judgement as to the order of synthetic steps, protecting groups, if required, and deprotection conditions. Substituents on the starting materials may be incompatible with some of the reaction conditions. Such restrictions to the substituents which are compatible with the reaction conditions will be apparent to one skilled in the art. Some of the compounds of the hereinbefore described schemes have center of asymmetry. The compounds may, therefore, exist in at least two and often more stereoisomeric forms. The present invention encompasses all stereoisomers of the compounds whether free from other stereoisomers or admixed with other stereoisomers in any proportion and thus includes, for instance, racemic mixture of enantiomers as well as the diastereomeric mixture of isomers. The absolute configuration of any compound may be determined by conventional X-ray crystallography. Pharmaceutically acceptable salts of the compounds of the invention may be obtained as metal complexes such as aluminum, calcium, iron, magnesium, manganese and complex salts; inorganic and organic salts and corresponding Mannich base adducts using methods known to those skilled in the art (Richard C. Larock, Comprehensive Organic Transformations, VCH Publishers, 411-415,1989). Preferably, the compounds of the invention are obtained as inorganic salts such as hydrochloric, hydrobromic, hydroiodic, phosphoric, nitric or sulfate; or organic salts such as acetate, benzoate, citrate, cysteine or other amino acids, fumarate, glycolate, maleate, succinate, tartrate alkylsulfonate or arylsulfonate. The salt formation preferentially occurs with the C(4)-dimethylamino group when forming inorganic salts. The salts are preferred for oral and parenteral administration. 31 WO 2005/056538 PCT/US2004/040850 Standard Pharmacological Test Procedures Methods for in Vitro Antibacterial evaluation The minimum inhibitory concentration (MIC) Antimicrobial susceptibility testing. The in vitro activities of the antibiotics are determined by the broth microdilution method as recommended by the National Committee for Clinical Laboratory Standards (NCCLS) (1). Mueller-Hinton II broth (MHBII)(BBL Cockeysville, MD) is the medium employed in the testing procedures. Microtiter plates containing serial dilutions of each antimicrobial agent are inoculated with each organism to yield the appropriate density (105 CFU/rnl) in a 100/71 final volume. The plates are incubated for 18 — 22 hours at 35°C in ambient air. The minimal inhibitory concentration for all isolates is defined as the lowest concentration of antimicrobial agent that completely inhibits the growth of the organism as detected by the unaided eye. 1. NCCLS. 2000. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically; Approved Standards: M7-A5, vol. 20. National Committe for Clinical Laboratory Standards, Wayne, PA. 32 WO 2005/056538 PCT/US2004/040850 WO 2005/056538 PCT/US2004/040850 WO 2005/056538 PCT/US2004/040850 WO 2005/056538 PCT/US2004/040850 WO 2005/056538 PCT/US2004/040850 WO 2005/056538 PCT/US2004/040850 WO 2005/056538 PCT/US2004/040850 WO 2005/056538 PCT/US2004/040850 WO 2005/056538 PCT/US2004/040850 When the compounds of the invention are employed as antibacterials, they can be combined with one or more pharmaceutically acceptable carriers, for example, solvents, diluents and the like, and may be administered orally in such forms as tablets, capsules, dispersible powders, granules, or suspensions containing, for example, from about 0.05 to 5% of suspending agent, syrups containing, for example, from about 10 to 50% of sugar, and elixirs containing, for example, from about 20 to 50% ethanol, and the like, or parenterally in the form of sterile injectable solutions or suspensions containing from about 0.05 to 5% suspending agent in an isotonic medium. Such pharmaceutical preparations may contain, for example, from about 25 to about 90% of the active ingredient in combination with the carrier, more usually between about 5% and 60% by weight. An effective amount of compound from about 2.0 mg/kg of body weight to about 100.0 mg/kg of body weight may be administered one to five times per day via any typical route of administration including but not limited to oral, parenteral (including subcutaneous, intravenous, intramuscular, intrastemal injection or infusion techniques), topical or rectal, in dosage unit formulations containing conventional non-toxic pharmaceutically acceptable carriers, adjuvants and vehicles. It will be understood, however, that the specific dose level and frequency of dosage for any particular patient may be varied and will depend upon a variety of factors including the activity of the specific compound employed, the metabolic stability and length of action of that compound, the age, body weight, general health, sex, diet, mode and time of administration, rate of excretion, drug combination, the severity of the particular condition, and the host undergoing therapy. These active compounds may be administered orally as well as by intravenous, intramuscular, or subcutaneous routes. Solid carriers include starch; lactose, dicalcium phosphate, microcrystalline cellulose, sucrose and kaolin, while liquid carriers include sterile water, polyethylene glycols, non-ionic surfactants and edible oils such as corn, peanut and sesame oils, as are appropriate to the nature of the active ingredient and the particular form of administration desired. Adjuvants customarily employed in the preparation of pharmaceutical compositions may be advantageously included, such as flavoring agents, coloring agents, preserving agents, and antioxidants, for example, vitamin E, ascorbic acid, BHT and BHA. 41 WO 2005/056538 PCT/US2004/040850 The preferred pharmaceutical compositions of compounds of the invention from the standpoint of ease of preparation and administration are solid compositions, particularly tablets and hard-filled or liquid-filled capsules. Oral administration of the compounds is preferred. These active compounds may also be administered parenterally or intraperitoneally. Solutions or suspensions of these active compounds as a free base or pharmacologically acceptable salt can be prepared in water suitably mixed with a surfactant such as hydroxy-propylcellulose. Dispersions can also be prepared in glycerol, liquid, polyethylene glycols and mixtures thereof in oils. Under ordinary conditions of storage and use, these preparations contain a preservative to prevent the growth of microorganisms. The pharmaceutical forms suitable for injectable use include sterile aqueous solutions or dispersions and sterile powders for the extemporaneous preparation of sterile injectable solutions or dispersions. In all cases, the form must be sterile and must be fluid to the extent that easy syringability exists. It must be stable under the conditions of manufacture and storage and must be preserved against the contaminating action of microorganisms such as bacterial and fungi. The carrier can bs a solvent or dispersion medium containing, for example, water, ethanol, polyol (e.g., glycerol, propylene glycol and liquid polyethylene glycol), suitable mixtures thereof, and vegetable oil. 42 WO 2005/056538 PCT/US2004/040850 The invention will be more fully described in conjunction with the following specific examples which are not to be construed as limiting the scope of the invention. Example of Procedure A EXAMPLE! (6aR,7aS,8S, 11 aS)-5,8-bis(dimethylamino)-2-(2,2-diphenylvinyl)-9,11 a, 12-trihydroxy-11,13-dioxo-6,6a,7,7al8,11,11a,13-octahydrotetraceno[2,1-d][1l3]oxazole-10- carboxamide 9-aminominocycline sulfate salt (0.500g, 0.748 mmol) is dissolved in anhydrous DMF and treated with p-phenylcinnama!dehyde (0.779g, 3.74 mmol, 5 equivalents) The solution is then treated with DDQ (0.085 g, 0.374 mmol, 0.5 equivalents) and stirred at room temperature for 5 min. ES+ mass spectrometry showed a 1:1 ratio of product and starting material. A second portion of DDQ (0.068 g, 0.300 mmol, 0.4 equivalents) is added. After approximately 5 minutes, acetonitrile (7.5 mL) is added, and the entire reaction mixture is poured slowly into ether (750 mL) The pink solid is removed by filtration and washed with fresh ether to yield 0.480g of the crude product. This material is dissolved in water (75 mL) to give a solution at pH 2.2, which is extracted with dichloromethane (2 X 100 mL) The pH of the aqueous layer is raised to 3.0 with aqueous ammonia, and the solution is again 43 WO 2005/056538 PCT/US2004/040850 extracted with dichloromethane (2 X 100 ml_.) The four organic extracts are dried (Na2SO4), filtered and concentrated to a volume of about 2 ml_ A small portion of methanol (1 mL) is added, and the concentrated solution is treated dropwise with 1M HCI in ether. The solid precipitate is filtered, washed with fresh ether and dried under vacuum the product as its HCI salt. Selected 1H NMR signals: 8 4.26 (s, 1H), 7.13 (s, 1H), 7.26-7.45 (m, 8H), 7.63 (s, 11-0,9.08(8,11-1), 9.54 (s,1H). The compounds of this invention listed below in Examples 2 to 37 are prepared substantially following the method described in detail hereinabove in, Example 1 using procedure A. EXAMPLE 2 (7aS,8S,11aS)-8-(dimethylamino)-9,11a,13-trihydroxy-2-(2-methyl-1-propenyl)-11,12-dioxo-7,7a,8,11,11 a, 12-hexahydronaphthaceno[2,1 -d][1,3Joxazole-10- carboxamide i MSm/z492(M+H) i HRMS: calcd for 026^6^0/, 491.16925; found (ESI+), 492.1765 44 WO 2005/056538 PCT/US2004/040850 EXAMPLE 3 (7aS,8S,11aS)-8-(dimethylamino)-2-[4-(dimethylamino)phenyl]-9,11a,13-trihydroxy-11,12-dioxo-7,7a,8,11,11a,12-hexahydronaphthaceno[2,1-d][1,3]oxazole-10- carboxamide HRMS: calcd for C^^NgO/, 566.1958; found (ES!+), 557.2030 EXAMPLE 4 (6aR,7aS,8S,11aS)-2-fe/f-butyl-5,8-bis(dimethylamino)-9,11a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide • MS (ESI) m/z539.3 (M+H); MS (ESI) m/2270.4 (M+2H); HRMS: calcd for CSBHMN^ • HCI, 574.2194; found (ESI-), 537.23462; 45 WO 2005/056538 PCT/US2004/040850 EXAMPLE 5 (6aR,7aS,8S,11 aS)-5,8-bis(dimethylamino)-9,11 a,12-trihydroxy-2-(4-methylphenyl)-11,13-dioxo-6,63,7,73,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazoie-10- carboxamide MS (ESI) m/z 573.3 (M+H); MS (ESI) m/z 287 (M+2H); HRMS: calcd for C3iH32N4O7 • HCI, 608.2038; found (ESI-), 571.21905; EXAMPLE 6 (7aS,8S,11 aS)-5,8-bis(dimethylamino)-2-(3-fluorophenyl)-9,11 a,13-trihydroxy-11,12-dioxo-7,7a, 8,11,11 a, 12-hexahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide 46 WO 2005/056538 PCT/US2004/040850 EXAMPLE 7 (6aR,7aS,8S,11 aS)-2-(4-cyanophenyl)-5,8-bis(dimethylamino)-9,11 a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole-10- carboxamide MS (ESI) m/z 584.4 (M+H); HRMS: calcd for C^HsgNsO/ • HCI, 619.1834; found (ES1-), 582.19817; i EXAMPLE 8 (6aR,7aS,8S,11aS)-5,8-bis(dimethylamino)-2-I4-(dimethylamino)phenyl]-9,11a,12-trihydroxy-11,13^0X0-6,68,7,73,8,11,11a,13-octahydrotetraceno[2,1-d][1,3]oxazole- 10-carboxamide MS (ESI) m/z 602.2 (M+H); MS (ESI) m/z 301.8 (M+2H); HRMS: calcd for C32H35NSO7 • HCI, 637.2303; found (ESI-), 600.24521; 47 WO 2005/056538 PCT/US2OO4/O4O85O EXAMPLE 9 (6aR)7aS,8S,11aS)-5,8-bis(dimethylarnino)-2-(2,2-diphenylvinyl)-9,11a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 ail 3-octahydrotetraceno[2,1-d][1,3]oxazole-10- carboxamide MS (ESI) m/z 661.3 (M+H); MS (ESI) m/z331.3 (M+2H); HRMS: calcd for CaaHaeN^ HCI, 696.2351; found (ESI-), 659.24957; EXAMPLE 10 (eaRJaS.SS.HaSJ^^S-tert-butyl^-hydroxyphenyO-S.S-bistdimethylamino)-9,11 a,12-trihydroxy-11,13-dioxo6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 - d][1,3]oxazole-10-carboxamide MS (ESI) m/z 631.4 (M+H); HRMS: calcd for C^s^Oe • HCI, 666.2456; found (ESI+), 631.27753; 48 WO 2005/056538 PCT/US2004/040850 EXAMPLE 11 (6aR,7aS,8S,11aS)-2-[4-(ben2yloxy)phenyl]-5)8-bis(dimethy!amino)-9,11a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a, 13-octahydrotetraceno[2,1 -d][1,3]oxazole- 10-carboxamide MS '(ESI) m/z 665.2 (M+H); HRMS: calcd for C37H36N4OB • HCI, 700.2300; found (ESI+), 665.26096; EXAMPLE 12 (6aR,7aSl8S,11aS)-2-(2,4-dihydroxyphenyl)-5,8-bis(dimethylamino)-9,11a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole- 10-carboxamide MS (ESI) m/z 591.2 (M+H); HRMS: calcd for C3oH3oN409" HCI, 626.1780; found (ESI-), 589.1927; 49 WO 2005/056538 PCT/US2004/040850 EXAMPLE 13 (6aR,7aS,8S,11 aS)-5,8-bis(dimethylamino)-2-(3-fluoro-4-methoxypheny!)-9,11 a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole- 10-carboxamide MS (ESI) m/z 607.3 (M+H); MS (ESI) m/z 304 (M+2H); HRMS: calcd for C3iH31FN4O8 • HCI, 642.1893; found (ESI-), 605.20519; EXAMPLE 14 (6aR,7aS,8S,11 aS)-2-(1,3-benzodioxol-5-yl)-5,8-bis(dimethylamino)-9,11 a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11a,13-octahydrotetraceno[2,1-d][1,3]oxazole- 10-carboxamide MS (ESI) m/z 603.3 (M+H); MS (ESI) m/z302.1 (M+2H); HRMS: calcd for C^HacMQg; HCI, 638.1780; found (ESI+), 603.20953; 50 WO 2005/056538 PCT/US2004/040850 EXAMPLE 15 (6aR,7aS,8S,11aS)-5,8-bis(dimethylamino)-9,11a,12-trihydroxy-11,13-dioxo-2-(2,4,6-trimethoxyphenylJ-e.ea^Ja.S, 11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole-1 flea rboxamide MS (ESI) m/z 649.2 (M+H); HRMS: calcd for (^aHaeN^Ao' HCI, 684.2198; found (ESI-), 647.23441; EXAMPLE 16 (6aR,7aSI8S,11aS)-5,8-bis(dimethylamino)-9,11a,12-trihydroxy-11,13-dioxo-2-(2,4,5-triethoxyphenyl)-6,6a,7,7a,8,11,11a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10- carboxamide MS (ESI) m/z691.3 (M+H); HRMS: calcd for CaehW^O™ ¦ HCI, 726.2668; found (ESI+), 691.29817; 51 WO 2005/056538 PCT/US2004/040850 EXAMPLE: 17 (6aR,7aS,8S,11aS)-5,8-bis(dimethylamino)-9,11a,12-trihydroxy-11,13-dioxo-2-thien-3-yl-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide MS (ESI) m/z565.2 (M+H); MS (ESI) m/z 283.4 (M+2H); HRMS: calcd for C28H28N4O7S • HCI, 600.1445; found (ESI-), 563.15992; EXAMPLE 18 (6aR,7aS,8S,11aS)-2-(1-benzofuran-2-yl)-5,8-bis(dimethylamino)-9,11a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a, 13-octahydrotetraceno[2,1 -d][1,3]oxazole- 10-carboxamide MS (ESI) m/z 599.3 (M+H); HRMS: calcd for C32H3oN408 • HCI, 634.1830; found (ESI-), 597.19811; 52 WO 2005/056538 PCT/US2004/040850 EXAMPLE 19 (6aR,7aS,8S,11aS)-5,8-bis(dimethylamino)-9I11a,12-trihydroxy-2-(1-methyl-1W-indol-2-yl)-11,13-0)10X0-6,63,7,73,8,11,11 a, 13-octahydrotetraceno[2,1 -d]f 1,3]oxazole- 10-carboxamide MS (ESI) m/z 612.2 (M+H); HRMS: calcd for C33H33N5O7 • HCI, 647.2147; found (ESI+), 612.24406; EXAMPLE 20 (6aR,7aS,8S,11 aS)-5,8-bis(dimethylamino)-2-(2-furyl)-9,11 a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide , MS (ESI) m/z 549.3 (M+H); HRMS: calcd for C28H28N4O8 • HCI, 584.1674; found (ESI-), 547.1822; . 53 WO 2005/056538 . PCT/US2004/040850 EXAMPLE 21 {5-[(6aR,7aS,8S, 11 aS)-10-(aminocarbonyl)-5,8-bis(dimethylamino)-9,11 a, 12-trihydroxy-11 ,i3-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazol-2- yl]-2-furyl}methyl acetate MS (ESI) m/z 621.2 (M+H); HRMS: calcd for Ca^^do ¦ HCI, 656.1885; found (ESI+), 621.21807; EXAMPLE 22 (6aR,7aSI8S,11aS)-5,8-bis(dimethy!amino)-2-[(E)-2-(2-furyl)ethenyl]-9,11a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a, 13-octahydrotetraceno[2,1 -d][1,3]oxazole- 10-carboxamide MS (ESI) m/z 575.2 (M+H); MS (ESI) m/z 288.3 (M+2H); HRMS: calcd for C30H30N4O8' HCI, 610.1830; found (ESI-), 573.1985; 54 WO 2005/056538 , PCT/US2004/040850 EXAMPLE 23 (6aR,7aS,8S,11 aS)-2-(1 -benzothien-3-yl)-5,8-bis(dimethylamino)-9,11 a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetracenot2,1 -d][1,3]oxazo!e- 10-carboxamide MS(ESI+)m/z615.1 ((M+H)+); HRMS: calcd for C32H3oN407S ¦ HCI, 650.1602; found (ESI+), 615.19036; EXAMPLE 24 (6aR,7aS,8S,11 aS)-5,8-bis(dimethylamino)-9,11 a,12-trihydroxy-11,13-dioxo-2-(1,3-thiazol-2-yl)-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10- carboxamide MS (ESI) m/z566.4 (M+H); MS (ESI) m/z283.6 (M+2H); HRMS: calcd for C^HayNsOTS • HCI, 601.1398; found (ESI+), 566.16973; 55 WO 2005/056538 PCT/US2004/040850 EXAMPLE 25 (6aR,7aS,8S,11aS)-5,8-bis(dimethylarnino)-9,11a,12-trihydroxy-11,13-dioxo-2-[(£)-2-phenylethenyll-e.eaJ.Ta.S.H.Ha.ia-octahydrotetracenop.i-dHI.Sloxazole-IO- carboxamide MS (ESI) m/z 585.4 (M+H); MS (ESI) m/z 293.3 (M+2H); HRMS: calcd for C32H32N4O7 ¦ HCI, 620.2038; found (ESI+), 585.2329; EXAMPLE 26 (6aR,7aS,8S,11 aS)-5,8-bis(dimethylamino)-9,11 a,12-trihydroxy-2-[(£)-2-(4-methoxyphenyl)ethenyl]-11,13-dioxo-6,6a,7,7a,8,11,11a,13-octahydrotetraceno[2,1- d][1,3]oxazole-10-carboxamide MS (ESI) m/z 615.3 (M+H); MS (ESI) m/z 308.3 (M+2H); HRMS: calcd for C33H34N4O8 • HCI, 650.2143; found (ESI+), 615.24413; 56 WO 2005/056538 PCT/US2004/040850 EXAMPLE 27 (6aR,7aS,8S, 11 aS)-5,8-bis(dimethylamino)-9,11 a, 12-trihydroxy-2-[(E)-2-(3-methoxyphenyl)ethenyl]-11,13-dioxo-6,6a,7,7a,8,11,11a,13-octahydrotetraceno[2,1- d][1,3]oxazole-10-carboxamide MS (ESI) m/z 615.4 (M+H); MS (ESI) m/z 308.3 (M+2H); HRMS: calcd for C33H34N4Oa • HCI, 650.2143; found (ESI+), 615.24419; EXAMPLE 28 (6aR>7aS,8S,11aS)-5I8-bis(dimethylamino)-9,11al12-trihydroxy-2-[(E)-2-(2-methoxyphenyl)ethenyl]-11,13-^0X0-6,63,7,73,8,11,11a,13-octahydrotetraceno[2,1- d][1,3joxazole-10-caiboxamide MS (ESI) m/z 615.3 (M+H); MS (ESI) m/z308.3 (M+2H); HRMS: calcd for C33H34N4O8 HCI, 650.2143; found (ESI+), 615.24408; 57 WO 2005/056538 PCT/US2004/040850 ; EXAMPLE 29 (6aR,7aS,8S,11aS)-5,8-bis(dimethylamino)-2-[(£)-2-(4-fiuorophenyl)ethenyl]-9,11a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11a,13-octahydrotetraceno[2,1- d][1,3]oxazole-10-carboxamide MS (ESI) m/z 603.3 (M+H); MS (ESI) m/z302.3 (M+2H); HRMS: calcd for C32H3iFN4O7 • HCI, 638.1944; found (ESI+), 603.22476; EXAMPLE 30 (6aR,7aS,8S,11aS)-5,8-bis(dimethylamino)-2-[(£)-2-(2-fluorophenyl)ethenyl]-9,11a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11a,13-octahydrotetraceno[2,1- d][1,3]oxazole-10-carboxamide MS (ESI) m/z603.2 (M+H);' MS (ESI) m/z 302.3 (M+2H); HRMS: calcd for CaaH^F^Or • HCI, 638.1944; found (ESI+), 603.22469; 58 WO 2005/056538 PCT/US2004/040850 EXAMPLE 31 (eaRjaS.SS.IIaSJ-Z^-ferf-butylphenyO-B.S-bisfdimethylaminoJ-^iia,^-trihydroxy-11,13-dioxo-6(6a,7,7a,8,11,11a,13-octahydrotetraceno[2,1-d][1,3]oxazole- 10-carboxamide MS (ESI) m/z615.3 (M+H); MS (ESI) m/z 308.3 (M+2H); HRMS: calcd for Ca^s^O? • HCI, 650.2507; found (ESI+), 615.28057; 59 WO 2005/056538 PCT/US2004/040850 EXAMPLE 32 (6aR,7aS,8S,11 aS)-5,8-bis(dimethylamino)-2-[4-(hexyloxy)phenyl]-9,11 a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11a,13-octahydrotetraceno[2,1-d]f1,3]oxazo!e- 10-carboxamide MS (ESI) m/z 659.4 (M+H); MS (ESI) m/z 330.4 (M+2H); HRMS: calcd for C36H42N4OB • HCI, 694.2769; found (ESI+), 659.30693; EXAMPLE 33 (6aR,7aS,8S,11aS)-5,8-bis(dimethylamino)-9,11a,12-trihydroxy-11,13-dioxo-2-pyridin-4-yl-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole-10- carboxamide 60 WO 2005/056538 PCT/US2004/040850 EXAMPLE 34 (eaR.yaS.aS.HaSJ-S.S-bisfdimethylaminoJ-g.Ha.^-trihyclroxy-II.IS-dioxo-a-pyridin-3-yl-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1 F3]oxazole-10- carboxamide MS (ESI) m/z560.3 (M+H); MS (ESI) m/z 280.7 (M+2H); HRMS: calcd for CsgHsgNsO? • HCI, 595.1834; found (ESI+), 560.21353; EXAMPLE 35 (6aR,7aS,8S,11aS)-2-(chloromethyl)-5,8-bis(dimethylamino)-9,11a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10- carboxamide MS (ESI) m/z 531.2 (M+H); MS (ESI) m/z266.3 (M+2H); 61 WO 2005/056538 PCT/US2004/040850 EXAMPLE 36 (6aR,7aS,8S>11aS)-5,8-bis(dimethylamino)-2-[(dimethylamino)methyl]-9(11a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole- 10-carboxamide MS (ESI) m/z540.4 (M+H); MS (ESI) m/z 270.7 (M+2H); HRMS: calcd for C27H33NsO7 ¦ HCI, 575.2147; found (ESI+), 540.24506; EXAMPLE 37 (6aR,7aS,8S,11aS)-5,8-bis(dimethylamino)-9,11a,12-trihydroxy-11,13-dioxo-2-(pyrrolidin-1-ylmethyl)-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole- 10-carboxamide MS (ESI) m/z566.4 (M+H); MS (ESI) m/z 283.9 (M+2H); HRMS: calcd for CssjHasNsO/ • HCI, 601.2303; found (ESI+), 566.26066; 62 WO 2005/056538 PCT/US2004/040850 Example of Procedure B EXAMPLE 38 (6aR,7aS,8S,11 aS)-5,8-bis(dimethylamino)-9,11 a,12-trihydroxy-11,13-dioxo-2-[(propylamino)methyl]-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -dj[1,3]oxazole- 10-carboxamide 9-aminominocycline sulfate salt (1.0 g, 1.50 mmol) is dissolved in DMF (50 mL) and treated with a solution of 2-chloro-1,1,1-trimethoxyethane (0.463 g, 3.00 mmol, 2 equivalents). The reaction is stirred at room temperature until mass spectrometry shows conversion to the chforomethylbenzoxazole derivative. The solution is then treated with n-propylamine (10 mL, excess) and stirred until mass spectrometry shows conversion to the n-propylaminomethy! benzoxazole. The mixture is concentrated under reduced pressure to remove excess n-propylamine, and then poured slowly into ether (1 L) and HCI/ether is added to precipate the salt. The solid is rinsed with fresh ether and dried under vacuum. The crude solid is dissolved in water (100 mL) giving a solution at pH 2. The pH is raised successively by 0.5 units with aqueous ammonia, and extracted with dichloromethane. The fractions extracted at pH 4-4.5 are combined, dried (Na2SO4), filtered and concentrated nearly to dryness. A small volume of methanol is added and the solution is treated with 1M HCI in ether. The precipitated solid is collected by filtration, washed with fresh ether and dried under vacuum to yield 0.067 g of the product as its HCI salt. Selected 1H NMR signals: 5 0.94 (t, 3H), 1.73 (m, 2H), 4.31 (s, 1H), 4.65 (s, 2H), 7.78 (s, 1H), 9.15 (s, 1H), 9.67 (s, 1H). 63 WO 2005/056538 PCT/US2004/040850 The compounds of this invention listed below in Examples 39 to 41 are prepared substantially following the method described in detail hereinabove in Example 38 using procedure B. (prepared from Procedure B) EXAMPLE 39 (6aR,7aS,8S, 11 aS)-2-[(butylamino)methyl]-5,8-bis(dimethylamino)-9,11 a, 12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole- 10-carboxamide MS (ESI) m/z568.3 (M+H); MS (ESI) m/z 284.8 (M+2H); MS (ESI) m/z 305.2 (M+ACN+2H); HRMS: calcd for C29H37N5O7 • HCI, 603.2460; found (ESI+), 568.27616; 64 WO 2005/056538 PCT/US2004/040850 (Procedure B) EXAMPLE 40 (6aR,7aS,8S,11aS)-5,8-bis(dimethylamino)-9,11a,12-trihydroxy-11,13-dioxo-2-[(propy]amino)methyl]-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole- 1O-carboxamide MS (ESI) m/z554.3 (M+H); MS (ESI) m/z277.7 (M+2H); HRMS: calcd for CasHasNsO? ¦ HCI, 589.2303; found (ESI+), 554.2604; (Procedure B) EXAMPLE 41 (6aR>7aS,8S,11aS)-2-[(tert-butylamino)methyI]-5,8-bis(dimethylamino)-9l11a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11a,13-octahydrotetracenot2,1-d][1,3]oxazole- 10-carboxamide 65 WO 2005/056538 PCT/US2004/040850 9-aminominocycline sulfate salt (1.0 g, 1.50 mmol) is dissolved DMF (20 ml_) and treated with a solution of 2-chlorotrimethoxyethane (0.35 g, 2.2 mmol, 1.46 equivalents). The reaction is stirred at room temperature until mass spectrometry showed conversion to the chloromethylbenzoxazole derivative. The solution is then treated with f-butylamine (7.3 mL, excess) and stirred until mass spectrometry showed conversion to the f-butylaminomethyl benzoxazole. The mixture is concentrated under reduced pressure to remove excess f-butylamine, and then poured slowly into ether (1 L) and HCI/ether is added to precipate the salt. The solid is rinsed with fresh ether and dried under vacuum, the crude solid is dissolved in water (100 mL) giving a solution at pH 2. The pH is raised successively by 0.5 units with aqueous ammonia, and extracted with dichloromethane. The fractions extracted at pH 4-4.5 are combined, dried (Na2SO4), filtered and concentrated nearly to dryness. A small volume of methanol is added and the solution is treated with 1M HCI in ether. The precipitated solid is collected by filtration, washed with fresh ether and dried under vacuum to give the product as its HCI salt. MS (ESI+) m/z 568.4 ((M+H)-*-); MS (ESI+) m/z284.9 ((M+2H)2+); MS (ESI+) m/z 146.3 ((M'+H)+); HRMS: calcd for C29H37NSO7 • HCI, 603.2460; fou nd (ESI-), 566.26087; Example of Procedure C EXAMPLE 42 (6aR,7aS,8S,11aS)-5,8-bis(dimethylamino)-9,11a,12-trihydroxy-11,13-dioxo-2-thioxo-2,3,6,6a,7,7a,8,11,11a,13-decahydrotetraceno[2,1-d][1,3]oxazole-10- carboxamide 66 WO 2005/056538 PCT/US2OO4/O40850 To a solution of 9-amino-mino disulfate (0.668 g, 1 mmol) in DMSO (30 ml_) is added 2 equivalents of 1,1-thiocarbonyldiimidazole. The reaction is then stirred at room temperature for 2 to 12 hr (followed by MS(ES)). The mixture then triturated with diethyl ether and the solid collected. Material is used in the next step without further purification. MS (ESI) m/2 515.2 (M+H); HRMS: calcd for ^HzeN^yS • H2SO4, 612.1196; found (ESI+), 515.15934; The compounds of this invention listed below in Examples 43 to 44 are prepared substantially following the method described in detail hereinabove in Example 42 using procedure C. Example of procedure C (Procedure C) EXAMPLE 43 benzyl {[(6aR,7aS,8S,11aS)-10-(aminocarbonyl)-5,8-bis(dimethylamino)-9,11a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a, 13-octahydrotetraceno[2,1 -d][1,3]oxazol-2- yl]thio}acetate 67 WO 2005/056538 PCT/US2004/040850 To a solution of (6aR,7aS,8S,11aS)-5,8-bis(dimethylamino)-9,11a,12-trihydroxy- 11,1 S-dioxo^-thioxo^Ae.eaJJa.S.I 1,11a,13-decahydrotetraceno[2,1- d][1,3]oxazole-10-carboxanriide (Example 42) in N,N-dimethylformamide (DMF) is added 2 equivalents of diisopropylethylamine, after stirring for 5 min. 1.2 equivalent of benzyl-2-bromoacetate is added. The reaction mixture is stirred for 1 hr and mixture triturated with diethyl ether and solid is collected. It is purified by extraction. MS (ESI) m/z 663.2 (M+H); MS (ESI) m/z 332.1 (M+2H); HRMS: calcd for C33H34N4O9S • HCI, 698.1813; found (ESI+), 663.2115; EXAMPLE 44 (6aR,7aS,8S,11 aS)-5,8-bis(dimethylamino)-2-[(4-fluorobenzyl)thio]-9,11 a,12-trihydroxy-11,13-dioxo-6,6al7,7a,8,11,11a,13-octahydrotetraceno[2,1-d][1I3]oxazole- 10-carboxamide ) The compound of the example is prepared using procedure D in Example 43 using 4-fluorobenzylbromide. MS (ESI) m/z 622.9 (M+H); > HRMS: calcd for C31H31FN4O7S • HCI, 658.1664; found (ESI+), 623.19689; 68 WO 2005/056538 PCT/US2004/040850 Example of Procedure D (Compound 1 to 4 to 6) Example 45 [4S-(4a)4aoc,5aa,12aa)]-4,7-Bis(dimethylamino)-9-[2-{1,1- dimethylethylamino)acetylamino]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a- tetrahydroxy-1,11 -dioxo-2-naphthacenecarboxamide. (mono HCI); (free base) 9-aminominocycline sulfate salt (1.0 g, 1.50 mmol) is dissolved DMF (20 mL) and treated with a solution of 2-chlorotrimethoxyethane (0.35 g, 2.2 mmol, 1.47 equivalents). The reaction is stirred at room temperature until mass spectrometry showed conversion to the chloromethylbenzoxazole derivative. The solution is then treated with f-butylamine (7.3 mL, excess) and stirred until mass spectrometry showed conversion to the f-butylaminomethyl benzoxazole. The mixture is concentrated under reduced pressure to remove excess f-butylamine, and then poured slowly into ether (1 L) and HCI/ether is added to precipate the salt. The solid is rinsed with fresh ether and dried under vacuum. The crude solid is dissolved in water (100 mL) giving a solution at pH 2. The pH is raised successively by 0.5 units with aqueous ammonia, and extracted with dichloromethane. The fractions extracted at pH 4-4.5 are combined, dried (Na2SO4), filtered and concentrated nearly to dryness. A small volume of methanol is added and the solution is treated with 1M HCI in ether. The precipitated solid is collected by filtration, washed with fresh ether and dried under vacuum to give the product as its HCI salt. 69 WO 2005/056538 PCT/US2OO4/040850 Product from example 41 is treated with aqueous acid for one hour to 24 hour to give mono HCL salt of example 45 MS (ESI+) m/z 586.4 ((M+H)+; The following examples are prepared using similar method described in procedure D. Example 46 [4S-(4a,4aa,5aa,12aa)]-4,7-Bis(dimethylamino)-9-[(dimethyamino)acetylamino]- 1,4,43,5,58,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11 -dioxo-2- naphthacenecarboxamide. MS (FAB) m/z 558 ((M+H)+; Example 47 [4S-(4a,4aa,5aa,12aa)]-4,7-Bis(dimethylamino)-9-[f(n-butylamino)acetyl]amino]- 1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11 -dioxo-2- naphthacenecarboxamide. MS (FAB) m/z 586 ((M+H)+; 70 PCT/US200/040850 WO 2005/056538 Example 48 t4S-(4a,4aa,5aa,12aa)]-4,7-Bis(dimethylamino)-9-[[(propylamino)acetyl]amino]- 1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11 -dioxo-2- naphthacenecarboxamide MS (FAB) /77/Z572 ((M+H)+; Example 49 [4S-(4a,4aa>5aa,12aa)]-4,7-Bis(dimethylamino)-9-[(chloroacetyi)amino]- 1,4,43,5,58,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11 -dioxo-2- naphthacenecarboxamide MS (FAB) m/z549 ((M+H)+; 71 WO 2005/056538 PCT/US2004/040850 WHAT IS CLAIMED IS: 1. A compound of Formula (I); wherein: X is selected from hydrogen, amino, NR11R12, alkyl of 1 to 12 carbon atoms optionally substituted , aryl of 6,10 or 14 carbon atoms optionally substituted, vinyl optionally substituted, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; A" is a moiety selected from the group: R11 and R12 are each independently H or alkyl of 1 to 12 carbon atoms or R11 and R12 when optionally taken together with the nitrogen atom to which each is attached form a 3 to 7 membered saturated hydrocarbon ring; Y is selected from hydrogen, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6,10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, vinyl, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; 72 WO2005/056538 PCT/US2004/040850 R is selected from alkyl of 1 to 12 carbon atoms optionally substituted, alkenyl of 2 to 6 carbon atoms optionally substituted, alkynyl of 2 to 12 carbon atoms optionally substituted, -CH2NR1R2, aryl of 6,10 or 14 carbon atoms optionally substituted, aralkyl of 7 to 16 carbon atoms optionally substituted, aroyl of 7 to 13 carbon atoms optionally substituted, SR3, heteroaryl of 5 or 6 ring atoms optionally substituted,' containing 1 to 4 heteroatoms which may be the same or different, independently selected from nitrogen, oxygen and sulfur, and heteroarylcarbonyl of 5 or 6 ring atoms optionally substituted containing 1 to 4 heteroatoms which may be the same or different, independently selected from nitrogen, oxygen and sulfur; R1 and R2 are each independently H or alkyl of 1 to 12 carbon atoms or R1 and R2 when optionally taken together with the nitrogen atom to which each is attached form a 3 to 7 membered saturated hydrocarbon ring; R3 is alkyl of 1 to 12 carbon atoms optionally substituted, -CH2-aryl optionally substituted, aralkyl of 7 to 16 carbon atoms optionally substituted, aroyl, -CH2(CO)0CH2aryl optionally substituted, -CH2-aikenyl of 2 to 12 carbon atoms optionally substituted, and -CH2-alkynyl of 2 to 12 carbon atoms optionally substituted; with the proviso that when X is NR1R2 and R1 is hydrogen, then R2 is methyl, ethyl, n-propyl, n-butyl, 1-methylethyl, 1-methy!propyl, 2-methylpropyl or 1,1-dimethylethyl; and that when R1 is methyl or ethyl then R2 is methyl, ethyl, n-propyl, 1-methylethyl, n-propyl, 1-methylpropyl, or 2-methylpropyl; or a tautomer or a pharmaceutically acceptable salt thereof. 2. A compound according to claim 1 wherein R is phenyl optionally substituted with 1 to 3 substituents or a pharmaceutically acceptable salt thereof. 3. A compound according to claim 1 wherein R of Formula (I) is selected from the group alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, and alkyl-heterocyclyl or a pharmaceutically acceptable salt thereof. 73 WO 2005/056538 PCT/US2004/040850 4. A compound according to claim 3 wherein alkyl-heterocyclyl is selected from moieties of the group or a pharmaceutically acceptable salt thereof. 5. A compound according to claim 2 wherein R is selected from moieties of the group 74 75 WO 2005/056538 PCT/US2004/040850 WO 2005/056538 PCT/US2004/040850 or a pharmaceutically acceptable salt thereof. 6. A compound according to claim 1 wherein R is heteroaryl or a pharmaceutically acceptable salt thereof. 7. A compound according to claim 6 wherein R is selected from moieties selected from the group or a pharmaceutically acceptable saltthereof. 8. A compound according to claim 1 wherein R is alkyl of 1 to 6 carbon atoms optionally substituted, alkenyl of 2 to 6 carbon atoms optionally substituted, 76 WO 2005/056538 PCT/US2OO4/040850 NH(cycloalkyl of 5 to 6 carbon atoms), NH(alkyl of 1 to 6 carbon atoms) and MH(alkyl of 1 to 6 carbon atoms)-aryl optionally substituted, or a pharmaceutically acceptable salt thereof. 9. A compound according to claim 1 wherein R is selected from moieties 77 WO 2005/056538 PCT/US2004/040850 or a pharmaceutically acceptable salt thereof. 78 WO 2005/056538 ' PCT/US2004/040850 10. A compound according to claim 1 wherein R is S-aikyl of 1 to 12 carbon atoms, S-CH2-aryl optionally substituted and S-CH2(CO)OCH2aryl optionally substituted or a pharmaceutically acceptable salt thereof. 11. A compound according to claim 10 wherein R is selected from moieties of the group or a pharmaceutically acceptable salt thereof. 12. A compound according to any one of claims 1 to 11 wherein Y is H. 13. A compound according to any one of claims 1 to 12 wherein X is -NMe2. 14. A compound according to claim 1 selected from the group: (6aR,7aS,8S,11 aS)-5,8-bis(dimethylamino)-2-(2,2-diphenylvinyl)-9,11a,12-trihydroxy- 11,13-dioxc~6,6a,7,7a,8,11,11 a, 13-octahydrotetracerio[2,1 -d][1,3]oxazole-10- carboxamide, : (7aS,8S, 11 aS)-8-(dimethylamino)-9,11 a, 13-trihydroxy-2-(2-methyl-1 -propenyl)- H.^-dioxo-^a.S.H.Ha.^-hexahydronaphthacenop.i-djfi.Sjoxazole-IO- carboxamide, 79 PCT/US2004/040850 WO 2005/056538 (6aR,7aS,8S,1 i aS)-2-fert-butyI-5,8-bis(dimethylamino)-9,11 a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11 aS)-5,8-bis(dimethylamino)-2-[(£)-2-(2-furyl)ethenyl]-9,11 a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11 aS)-5,8-bis(dimethylamino)-9,11 a,12-trihydroxy-11,13-dioxo-2-[(£)-2-phenylethenyl]-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11 aS)-5,8-bis(dimethylamino)-9,11 a,12-trihydroxy-2-[(iE)-2-(4-methoxyphenyl)ethenyl]-11,13-dioxo-6,6a,7,7a,8,11,11a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11 aS)-5,8-bis(dimethylamino)-9,11 a,12-trihydroxy-2-[(£)-2-(3-methoxyphenyl)etheny!]-11,13-dioxo-6,6a,7,7a,8,11,11a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11 ,aS)-5,8-bis(dimethylamino)-9,11 a,12-trihydroxy-2-[(E)-2-(2-methoxyphenyl)ethenyl]-11,13-dioxo-6,6a,7,7a,8,11,11a,13-octahydrotetraceno[2,1-, d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11aS)-5,8-bis(dimethylamino)-2-[(£)-2-(4-fluorophenyl)ethenyl]-9,11a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11 aS)-5,8-bis(dimethylamino)-2-[(E)-2-(2-fluorophenyl)ethenyl]-9,11 a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,l 1,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazo!e-10-carboxamide, 80 WO 2005/056538 PCT/US2004/040850 (6aR,7aS,8S,11aS)-2-(ch[oromethyl)-5,8-bis(dimethylamino)-9,11a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11 aS)-5,8-bis(dimethy!amino)-2-[(dimethylamino)methyl]-9,11 a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11 aS)-5,8-bis(dimethylamino)-9,11 a,12-trihydroxy-11,13-dioxo-2-(pyrro!idin-1 -ylmethyl)-6,6a,7,7a,8,11,11 a, 13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11 aS)-5,8-bis(dimethylamino)-9,11 a,12-trihydroxy-11,13-dioxo-2-[(propylamino)methyl]-6,6a,7f7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11 aS)-2-[(butylamino)methyl]-5,8-bis(dimethylamino)-9,11 a,12-trihydroxy-11,13^10X0-6,63,7,78,8,11,11a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11aS)-5,8-bis(dimethylamino)-9,11a,12-trihydroxy-11,13-dioxc-2-[(propylaminoJmethylJ-e.eaJJa.S.11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide and (6aR,7aS,8S,11aS)-2-[(ferf-butylamino)methyl]-5,8-bis(dimethylamino)-9,11a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide; or a pharrnaceutically acceptable salt thereof. 15. A compound according to claim 1 selected from the group: 81 WO2005/056538 PCT/US2004/040850 (7aS,8S,11 aS)-8-(dimethylamino)-2-[4-(dimethylamino)phenyl]-9,11 a,13-trihydroxy-11,12-dioxo-7,7a,8,1J ,11a,12-hexahydronaplithaceno[2,1-d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11aS)-2-tert-butyl-5,8-bis(dimethylamino)-9,11 a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11 aS)-5,8-bis(dimethylamino)-9,11 a,12-trihydroxy-2-(4-methylphenyl)-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d]f1,3]oxazole-10-carboxamide, (7aS,8S)11aS)-5,8-bis(dimethylamino)-2-(3-fluorophenyl)-9,11a,13-trihydroxy-11I12-dioxo-7,7a,8,11,11a,12-hexahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide, (6aR,7aS>8S,11aS)-2-(4-cyanophenyl)-5,8-bis(dimethylamino)-9,11a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a, 13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11aS)-5,8-bis(dimethy!amino)-2-[4-(dimethylamino)phenyl]-9,11a,12-trihydroxy-11,13^10X0-6,63,7,73,8,11,11 a,13-octahydrotetr3ceno[2,1 -d][1,3]ox3zole-10-carboxamide, (6aR,7aS,8S,11aS)-2-(5-terf-butyl-2-hydroxyphenyl)-5,8-bis(dimethylamino)-9,11a,12-trihydroxy-11,13^10X0-6,63,7,78,8,11,11a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S, 11 aS)-2-[4-(benzyloxy)phenyl]-5,8-bis(dimethylamino)-9,11 a, 12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide, 82 PCT/US2004/O40850 WO 2005/056538 (6aR,7aS,8S,11aS)-2-(2,4-clihydroxyphenyl)-5,8-bis(climethylamino)-9,11a,12-trihydroxy-11,13-^0X0-6,63,7,78,8,11,11 a,13-octahydrotelraceno[2,1 -d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11 aS)-5,8-bis(dimethyIamino)-2-(3-fluoro-4-methoxyphenyl)-9,11 a,12-irihydroxy-11,13-^0X0-6,63,7,78,8,11,11a, 13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide, (6aRJ7aS,8S,11aS)-2-(1,3-ben2odioxol-5-yl)-5,8-bis(dimethylamino)-9,11a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11aS)-5,8-bis(dimethylarnino)-9,11a,12-trihydroxy-11,13-dioxo-2-(2,4,6-trimethoxyprienyl)-6,6a>7)7a,8,11J11a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide, (6aR,7aS,85,11 aS)-5,8-bis(dimethylamino)-9,11 a,12-trihydroxy-11,13-dioxo-2-(2,4,5-triethoxyphenyl)-6,6a,7,7a,8,11,11a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide, (6aR,7aS,85,11 aS)-5,8-bis(dimethylamino)-9,11 a,12-trihydroxy-2-(1-methyl-1 H-indol-2-yl)-11,13-dioxo-6,6a,7,7a,8,11,11a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide, (6aRI7aS,8S,11aS)-2-(4-terf-butylphenyl)-5,8-bis(dimethylamino)-9,11a,12- trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole- 10-carboxamide and : (6aR,7aS,8S,11 aS)-5>8-bis(dimethylamino)-2-[4-(hexylbxy)phenyl]-9,11 a,12-trihydroxy-11,1 S-dioxo-e.eaJJa.S.11,11 a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide or a pharmaceutically acceptable salt thereof. 83 WO 2005/056538 PCT/US2004/040850 16. A compound according to claim 1 selected from the group: (6aR,7aS,8S,11 aS)-5,8-bis(dimethylamino)-9,11 a,12-trihydroxy-11,13-dioxo-2-thien-3-yl-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11 aS)-2-(1 -benzofuran-2-y1)-5,8-bis(dimethylamino)-9,11 a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a, 13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11 aS)-5,8-bis(dimethylamino)-2-(2-furyl)-9,11 a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazole-10-carboxamide, {5-[(6aR,7aS,8S,11aS)-10-(aminocarbonyl)-5,8-bis(dimethylarnino)-9,11a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1 -d][1,3]oxazol-2-yl]-2-furyl}methyl acetate, (6aR,7aS,8S,11aS)-2-(1-benzothien-3-yl)-5,8-bis(dimethylamino)-9,11a,12-trihydroxy-11,13-dioxo-6,6a,7,7a,8,11,11a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide, (6aR,7aS,8S,11aS)-5,8-bis(dimethylamino)-9,11a,12-trihydroxy-11,13-dioxo-2-(1,3-thiazo!-2-yl)-6,6a,7,7a,8,11,11 a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide, (eaRJaS.SS.HaSJ-S.S-bisCdimethylaminoi-g.na.^-trihydroxy-II.IS-dioxo^-pyridin-4-yl-6,6a,7,7a,8,11,11a,13-octahydrotetraceno[2,1-d][1,3]oxazole-10-carboxamide and (6aR,7aS,8S,11 aS)-5,8-bis(dimethylamino)-9,11 a,12-trihydroxy-11,13-dioxo-2- pyridin-a-yl-e.eaJJa.S.H.Ha.iS-octahydrotetracenop.i-dJti.Sloxazole-IO- carboxamide or a pharmaceutically acceptable salt thereof. 84 WO 2005/056538 PCT/US2OO4/O4O850 17. A pharmaceutical composition comprising a compound according to any one of claims 1 to 16 or a pharmaceutically acceptable salt thereof in association with a pharmaceutically acceptable carrier. 18. A method for the treatment or control of bacterial infections in warm-blooded animals which comprises administering to said animal a pharmacologically effective amount of a compound according to any one of claims 1 to 16 or a pharmaceutically acceptable salt thereof. 19. A process for the preparation of a compound of the formula or a pharmaceutically acceptable salt thereof wherein: X is selected from hydrogen, amino, NR11R12, alkyl of 1 to 12 carbon atoms optionally substituted , aryl of 6, 10 or 14 carbon atoms optionally substituted, vinyl, optionally substituted, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; R1 and R2 are each independently H or alkyl of 1 to 12 carbon atoms or R1 and R2 when optionally taken together with the nitrogen atom to which each is attached form a 3 to 7 membered saturated hydrocarbon ring; R11 and R1Z are each independently H or alkyl of 1 to 12 carbon atoms or R11 and R1Z when optionally taken together with the nitrogen atom to which each is attached form a 3 to 7 membered saturated hydrocarbon ring; 85 WO 2005/056538 PCT/US2O04/04O85O Y is selected from hydrogen, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6,10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, vinyl, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; comprising the steps: a. reacting 7-(substituted)-8-(substituted)-9-amino-6-demethyl-6-deoxytetracycline of the formula ; or a pharmaceutically acceptable salt thereof with 2-chlorotrimethoxyethane in an aprotic solvent to afford a chloro compound of the formula b. reacting the chloro compound with an amine R1R2NH to form a substituted amine of the formula 86 WO 2005/056538 PCT/US2004/040850 c. hydrolyzing the substituted amine with acid to give a compound of the formula d. isolating the compound or a pharmaceutically acceptable salt thereof. 20. The process according to claim 19 wherein X is N(CH3)2. 21. The process according to claim 19 or claim 20 wherein the amine R1R2NH is t-butyl amine. 22. The process according to any one of claims 19 to 21 wherein the aprotic solvent is N.N-dimethylformamide. 23. The process according to any one of claims 19 to 22 wherein [4S- (4a,4aa,5aa,12aa)]-4,7-Bis(dimethylamino)-9-[2-(1,1- dimethylethylamino)acetylamino]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a- tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide or a pharmaceutically acceptable salt thereof is prepared. 24. A process for the preparation of a compound of the formula 87 WO 2005/056538 PCT/US2004/040850 wherein: X is selected from hydrogen, amino, NR11R12, alkyl of 1 to 12 carbon atoms optionally substituted , aryl of 6,10 or 14 carbon atoms optionally substituted, vinyl, optionally substituted, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; R1 and R2 are each independently H or alkyl of 1 to 12 carbon atoms or R1 and R2 when optionally taken together with the nitrogen atom to which each is attached form a 3 to 7 membered saturated hydrocarbon ring; R11 and R12 are each independently H or alkyl of 1 to 12 carbon atoms or R11 and R12 when optionally taken together with the nitrogen atom to which each is attached form a 3 to 7 membered saturated hydrocarbon ring; Y is selected from hydrogen, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6, 10 or 14 carbon atoms optionally substituted, vinyl, alkenyl of 2 to 12 carbon atoms optionally substituted, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; or a pharmaceutically acceptable salt thereof comprising the steps: a. reacting 7-(substituted)-8-(substituted)-9-amino-6-demethyl-6-deoxytetracycline of the formula or a pharmaceutically acceptable salt thereof with 2-chlorotrimethoxyethane in an aprotic solvent to afford a chloro compound of the formula 88 PCT/US2004/040850 WO 20O5/056538 b. reacting the chloro compound with acid to give 9-(2- ch!oromethylcarbonylamino)substituted-6-demethyI-6-deoxytetracyclineofthe formula c. reacting the 9-(2-chloromethylcarb6ny!amino)substituted-6-demethyl-6- deoxytetracycline with amine R1R2NH to give a compound of the formula e. isolating the compound or a pharmaceutically acceptable salt thereof. 25. The process according to claim 24 wherein X is N(CH3)2. 26. The process according to claim 24 or claim 25 wherein the amine R1R2NH is t-butyl amine. 89 PCT/US2004/040850 WO 2005/056538 27. The process according to any one of claims 24 to 26 wherein the aprotic solvent is N,N-dimethylformamide. 28. The process according to any one of claim 24 to 27 wherein [4S- (4a,4aa,5aa, 12aa)]-4,7-Bis(dimethylamino)-9-[2-(1,1 - dimethylethylamino)acetylamino]-1,4,43,5,58,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide or a pharmaceutically acceptable salt thereof is prepared. 29. A compound of the formula or a pharmaceutically acceptable salt thereof wherein: X is selected from hydrogen, amino, NR11R12, alkyl. of 1 to 12 carbon atoms optionally substituted, aryl of 6,10 or 14 carbon atoms optionally substituted, vinyl, optionally substituted, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; R1 and R2 are each independently H or alkyl of 1 to 12 carbon atoms or R1 and R2 when optionally taken together with the nitrogen atom to which each is attached form a 3 to 7 membered saturated hydrocarbon ring; R11 and R12 are each independently H or alkyl of 1 to 12 carbon atoms or R11 and R12 when optionally taken together with the nitrogen atom to which each is attached form a 3 to 7 membered saturated hydrocarbon ring; 90 WO 2005/056538 PCT/US2004/040850 Y is selected from hydrogen, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6,10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted vinyl, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; produced by the process comprising the steps: a. reacting 7-(substituted)-8-(substituted)-9-amino-6-demethyl-6-deoxytetracycline of the formula or a pharmaceutically acceptable salt thereof with 2-chlorotrimethoxyethane in an aprotic solvent to afford a chloro compound of the formula b. reacting the chloro compound with an amine R1R2NH to form a substituted amine of the formula 91 WO 2005/056538 PCT/US2OO4/04085O c. hydrolyzing the substituted amine with acid to give a compound of the formula and d. isolating the compound or a pharmaceutically acceptable salt thereof. 30. The product produced by the process according to claim 29 wherein X is N(CH3)2. 31. The product produced by the process according to claim 29 or claim 30 wherein the amine R1R2NH is t-butyl amine. 32. The product produced by the process according to any one of claims 29to 31 wherein the aprotic solvent is N,N-dimethylformamide. 33. The product produced by the process according to any one of claims 29 to 31 which is [4S-(4a,4aa,5aa,12aa)]-4,7-Bis(dimethylamino)-9-[2-(1,1- dirnethylethylamino)acetylamino]-1,4,4a,5,5a,6,11,12a-octahydro-3;10,12,12a- tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide or a pharmaceutically acceptable salt thereof. 34. A compound of the formula 92 WO 2005/056538 PCT/US2004/040850 wherein: X is selected from hydrogen, amino, NR11R12, alkyl of 1 to 12 carbon atoms optionally substituted , aryl of 6,10 or 14 carbon atoms optionally substituted, vinyl optionally substituted, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; R1 and R2 are each independently H or alkyl of 1 to 12 carbon atoms or R1 and R2 when optionally taken together with the nitrogen atom to which each is attached form a 3 to 7 membered saturated hydrocarbon ring; R11 and R12 are each independently H or alkyl of 1 to 12 carbon atoms or R11 and R12 when optionally taken together with the nitrogen atom to which each is attached form a 3 to 7 membered saturated hydrocarbon ring; Y is selected from hydrogen, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6,10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, vinyl, alkynyl of 2 to 12 carbon atoms optionally substituted 1 and halogen; or a pharmaceutically acceptable salt thereof produced by the process comprising the steps: a. reacting 7-(substituted)-8-(substituted)-9-amino-6-demethyl-6-i deoxytetracycline of the formula 93 WO 2005/056538 PCT/US2004/040850 or a pharmaceutically acceptable salt thereof with 2-chlorotrimethoxyethane in an aprotic solvent to afford a chloro compound of the formula b. reacting the chloro compound with acid to give 9-(2- chloromethyIcarbonylamino)substituted-6-demethyl-6-deoxytetracyclineof the formula c. reacting the 9-(2-chloromethylcarbony!amino)substituted-6-demethy!-6- deoxytetracycline with amine R1RZNH to give a compound of the formula and 94 WO 2005/056538 PCT/US2OO4/O4O85O d. isolating the compound or a pharmaceutically acceptable salt thereof. 35. The product prepared by the process according to claim 34 wherein X is N(CH3)Z. 36. The product prepared by the process according to claim 34 or claim 35 wherein the amine R1R2NH is t-butyl amine. 37. The product prepared by the process according to any one of claims 32 to 36 wherein the aprotic solvent is N.N-dimethylformamide. 38. The product prepared by the process according to any one of claims 34 to 37 which is [4S-(4a,4aa,5aa,12aa)]-4,7-Bis(dimethylamino)-9-[2-(1,1- dimethytethylarnino)acetylamino]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a- tetrahydroxy-1,11 -dioxo-2-naphthacenecarboxamide or a pharmaceutically acceptable salt thereof. 39. A process for preparing a compound of formula 1 according to claim 1 which comprises a). reacting 7-(substituted)-8-(substituted)-9-amino-6-demethyl-6-deoxytetracycline of the formula or a pharmaceutically acceptable salt thereof with 2-chlorotrimethoxyethane in an aprotic solvent to afford a chloro compound of the formula 95 WO 2005/056538 PCT/US2004/040850 wherein the variables are as defined in claim 1; or b. reacting a chloro compound of formula wherein the variables are as defined in claim 1; with an amine R1R2NH to form a substituted amine of the formula or c) converting a basic compound of formula I as defined in claim 1 to a pharmaceutically acceptable salt thereof or vice versa. 40. A process for preparing a compound of formula: 96 WO 2005/O56538 PCT/US2004/040850 wherein the variables are as defined in claim 34 which comprises: a) reacting a 9-(2-chloromethylcarbonylamino)substituted-6-demethyl-6-deoxytetracycline of the formula with an amine R1R2NH to give a compound of the formula or b) hydrolyzing a substituted amine of formula , 97 WO 2005/056538 PCT/US2004/040850 wherein the variables are as defined in claim 29, with acid to give a compound of the formula and if desired converting the product to a pharmaceutically acceptable salt thereof. 98

Documents:

01484-kolnp-2006-abstract.pdf

01484-kolnp-2006-assignment.pdf

01484-kolnp-2006-claims.pdf

01484-kolnp-2006-correspondence other.pdf

01484-kolnp-2006-correspondence others-1.1.pdf

01484-kolnp-2006-correspondence-1.2.pdf

01484-kolnp-2006-description complete.pdf

01484-kolnp-2006-form 1.pdf

01484-kolnp-2006-form 3.pdf

01484-kolnp-2006-form 5.pdf

01484-kolnp-2006-form-18.pdf

01484-kolnp-2006-form-3-1.1.pdf

01484-kolnp-2006-international publication.pdf

01484-kolnp-2006-international search report.pdf

01484-kolnp-2006-pct form.pdf

01484-kolnp-2006-priority document.pdf

1484-KOLNP-2006-AMANDED CLAIMS.pdf

1484-KOLNP-2006-CORRESPONDENCE.pdf

1484-kolnp-2006-description (complete) 1.1.pdf

1484-KOLNP-2006-FORM 1 1.1.pdf

1484-KOLNP-2006-FORM 2.pdf

1484-KOLNP-2006-FORM 3 1.1.pdf

1484-KOLNP-2006-OTHERS.pdf

1484-KOLNP-2006-PETITION UNDER RULE 137.pdf

abstract-01484-kolnp-2006.jpg