Title of Invention	"PREPARATION OF OLMESARTAN MEDOXOMIL"
Abstract	process for preparing olmesartan medoxomil comprising: a) contacting trityl olmesartan medoxomil with an acid of the kind such as herein described in a water miscible organic solvent of the kind such as herein described to obtain a solution of olmesartan medoxomil and a precipitate of triphenyl carbinol; b) separating the precipitate of triphenyl carbinol from the solution of olmesartan medoxomil; c) contacting the solution of olmesartan medoxomil with a base to obtain a precipitate of olmesartan medoxomil; and d) recovering olmesartan medoxomil.

Title of Invention

"PREPARATION OF OLMESARTAN MEDOXOMIL"

Abstract

process for preparing olmesartan medoxomil comprising: a) contacting trityl olmesartan medoxomil with an acid of the kind such as herein described in a water miscible organic solvent of the kind such as herein described to obtain a solution of olmesartan medoxomil and a precipitate of triphenyl carbinol; b) separating the precipitate of triphenyl carbinol from the solution of olmesartan medoxomil; c) contacting the solution of olmesartan medoxomil with a base to obtain a precipitate of olmesartan medoxomil; and d) recovering olmesartan medoxomil.

Full Text	The present invention relates to a process for preparing olmesartan medoxomil. This application claims the benefit of U.S. Provisional Patent Application Ser. No. 60/606,437 filed September 2,2004. FIELD OF INVENTION The present invention relates to processes for preparing olmesartan medoxomil. BACKGROUND OF THE INVENTION The chemical name for olmesartan medoxomil is 4-(l-hydroxy-l-methylethyl)-2-propyl-l-[[2'-(lH-tetrazol-5-yl)[l,r-biphenyl]-4-yl]methyl]-lH-irnidazole-5-carboxylic acid (5-methyl-2-oxo-l,3-dioxol-4-yl)methyl ester (Merck Index 13th ed.). The chemical structure of olmesartan medoxomil is: (Formula Removed) The empirical formula is C29H30N6O6. The molecular weight is 558.58. Olmesartan medoxomil is a prodrug that is hydrolyzed during absorption, and it is a selective AT) subtype angiotensin II receptor antagonist. Olmesartan medoxomil is disclosed by U.S. Patent No. 5,616,599 to Yanagisawa et al. It is marketed as BENICAR® in film-coatqd tablets of 5 mg, 20 mg, and 40 mg for treatment of hypertension in a human. The synthesis of olmesartan medoxomil (OLM-Mod)per se is illustrated as follows (see also Annu. Rep. Sankyo Res. Lab 2003, 55, 1-91): (Figure Remove) The prior art synthetic methods focus on the coupling between the substituted imidazole and the substituted biphenyl methylene bromide. Additional synthetic methods for these olmesartan medoxomil intermediates are described by: JP 11302260, JP 11292851, JP 07053489, JP 06298683, US 5621134, EP 838458, DE 19757995, US 6111114, and US 6214999. Step (vi) (the deprotection step) of the prior art synthesis is illustrated as follows: (Figure Remove) MTT OLM-M od crude Example 61(b) of the '599 patent discloses a process for preparing crude olmesartan medoxomil from a mixture of trityl olmesartan medoxomil (MTT) and aqueous acetic acid. Col. 176, lines 24-37. Triphenyl carbinol (TPC) is removed, and ohnesartan medoxomil is isolated by evaporation. in solution MTT acetScacid > OLM-Mod + TPC .-» OLM-Mod evaPoratio^ OLM-Mod crude f 1 H2O TPC Because of the acidic conditions and the presence of water, the impurity OLM-acid is also formed during the reaction by hydrolysis of the ester bond. The prior art process yields crude ohnesartan medoxomil containing 2.2% OLM-acid per area percent HPLC. There is a need for improved processes for preparing ohnesartan medoxomil. SUMMARY OF THE INVENTION In one aspect, the present invention provides a process for preparing ohnesartan medoxomil including the steps of: contacting trityl ohnesartan medoxomil with an acid in a water miscible organic solvent, with or without water, preferably acetone and water, to obtain a solution of ohnesartan medoxomil and a precipitate of triphenyl carbinol; separating the precipitate of triphenyl carbinol from the solution of olmesartan medoxomil; and contacting the solution of olmesartan medoxomil with a base to obtain a precipitate of ohnesartan medoxomil. DETAILED DESCRIPTION OF THE INVENTION The present invention provides a process for preparing ohnesartan medoxomil including the steps of: contacting trityl ohnesartan medoxomil with an acid in a water miscible organic solvent, with or without water, to obtain a solution of ohnesartan medoxomil and a precipitate of triphenyl carbinol; separating the precipitate of triphenyl carbinol from the solution of ohnesartan medoxomil; and contacting the solution of olmesartan medoxomil with a base to obtain a precipitate of ohnesartan medoxomil. Preferred water miscible organic solvents include, but are not limited to, acetone, acetonitrile, and t-butanol. Acetone is especially preferred. Preferably, the trityl ohnesartan medoxomil is contacted with a mixture of a water miscible organic solvent and water. Most preferably, the trityl olmesartan medoxomil is contacted with a mixture of acetone and water. Preferably, the ratio of water to the water miscible organic solvent, e.g., acetone, is preferably about 1:3 to about 3:1 by volume. The acid that is contacted with the trityl ohnesartan medoxomil removes the triphenyl carbinol to form an acid salt of olmesartan medoxomil. Preferably, the acid is a strong acid having a pH of about 0 to about 4. Suitable acids include, but are not limited to, organic acids such as formic acid, acetic acid, benzoic acid, and oxalic acid; oxoacids such as perchloric acid, chloric acid, chlorous acid, hypochlorous acid, sulfuric acid, sulfurous acid, p-toluene sulfonic acid, nitric acid, nitrous acid, phosphoric acid, and carbonic acid; and binary acids such as hydrofluoric acid, hydrochloric acid, hydrobromic acid, hydrocyanic acid, and hydrosulfuric acid. Hydrochloric acid, p-toluene sulfonic acid, and especially sulfuric acid are preferred. Preferably, the amount of acid is about 2 to about 8 equivalents, more preferably about 3 to about 4 equivalents, and most preferably about 3 equivalents. When contacting the trityl olmesartan medoxomil with the acid, the temperature is preferably about 10°C to about 60°C, more preferably about 40°C. In a preferred embodiment, the combination of trityl olmesartan medoxomil, the water miscible organic solvent, and the acid is maintained for about 3 to about 15 hours. Preferably, the combination is maintained for about 4 to about 6 hours, most preferably for about 4 hours. In a preferred embodiment, prior to separating the triphenyl carbinol, water is added to avoid the formation of undesired by-products. Preferably, the amount of added water is about 2 volumes per gram of trityl olmesartan medoxomil. Precipitation can be perceived visually as a clouding of the solution or formation of distinct particles of the precipitate suspended in the solution or collected at the bottom the vessel containing the solution. Separating the triphenyl carbinol from the solution can be performed by any means known in the art, such as filtration or centrifugation. After separating the triphenyl carbinol, the olmesartan medoxomil solution is contacted with a base. Suitable bases include, but are not limited to, alkali and alkaline earth metal hydroxides, carbonates, and hydrogen carbonate salts. Specific exemplary bases include, but are not limited to, sodium hydroxide, potassium hydroxide, calcium hydroxide, magnesium hydroxide, sodium carbonate, potassium carbonate, sodium bicarbonate, potassium bicarbonate, and calcium carbonate. Potassium carbonate and especially sodium bicarbonate are preferred. Preferably, the equivalents of base used is about equal to the equivalents of acid used, that is, the amount of base used is preferably about 0.8 to 1.5 equivalents compared to the amount of acid used. The base preferably increases the pH of the solution, but the solution need not reach a basic pH. After contacting the solution with the base, the solution is preferably maintained at a temperature of about 2°C to about 25'C, preferably at about room temperature. As used herein, the term "room temperature" refers to a temperature of about 20°C to 30°C, preferably 20°C to 25°C. The solution is maintained until olmesartan medoxomil is precipitated. The precipitate of olmesartan medoxomil can then be recovered by any means known in the art, such as filtration or centrirugation. Olmesartan medoxomil is recovered in its free base form, i.e., the nitrogen on the tetrazole is free. The reaction progress can be detected by any method known in the art, such as, for example, HPLC, GC, TLC, NMR, and mass spectroscopy. An exemplary embodiment of the present invention is depicted by the folio whig scheme: (Figure Remove) By using the process of the present invention, olmesartan medoxomil can be obtained directly, without the evaporation step required by the prior art process, which is an inconvenient industrial method. See U.S. Patent No. 5,616,599 Example 61(b). Also, the product of the '599 process is obtained in a gel-like form, which is difficult to handle in an industrial process. In addition to presenting industrial disadvantages, the '599 process achieves a lower yield than that obtained by the present invention. Additionally, the olmesartan medoxomil obtained according to the present invention has a lower amount of the impurity olmesartan acid (OLM-acid). Crude olmesartan medoxomil prepared according to the '599 process contains 2.2% OLM-acid. hi contrast, crude olmesartan medoxomil prepared according the present invention contains less than about 1% OLM-acid, e.g., only about 0.89% OLM-acid. All percentages of impurities described herein are provided as area percentage HPLC at 220 nm. EXAMPLES Examplp 1: Preparation of olmesartan medoxomil A 250 round bottom flask was charged with MTT (10 g), acetone/water (2/2 vol.), and 3 eq of H2S04. The combination was stirred at room temperature for about 4-6 hrs. Triphenyl carbinol (TPC) was precipitated by adding water and filtered out. NaHCOa was added to the filtrate, and the mixture was cooled to 5°C and stirred for 1 hr. Crude olmesartan medoxomil was obtained as white crystals (90% yield). Example 2: Preparation of crude olmesartan medoxomil A 1L reactor, equipped with mechanical stirrer and thermometer, was charged with MTT (70 g), acetone (140 ml), water (140 ml), and H2SO4 (19.47 g). The reactor was heated to 40°C for 2.5 hrs (at EOR, MTT is LT 1%). Water (140 ml) was added at 40°C, and the reaction was stirred for 1.5 hrs or until MTT is LT 0.1%. After cooling to 15°C and stirring for 1 hr, the TPC was filtered and washed with water (70 ml). NaHCOs was added in portions to the filtrate at room temperature. The reaction mixture was stirred for 1 hr, then filtrated, and the cake was washed with water (140 ml). The solid was dried at 45°C in a vacuum oven overnight to obtain crude OLM-Mod (98 % yield). Having thus described the invention with reference to particular preferred embodiments and illustrative examples, those in the art can appreciate modifications to the invention as described and illustrated that do not depart from the spirit and scope of the invention as disclosed in the specification. The examples are set forth to aid in understanding the invention but are not intended to, and should not be construed to, limit its scope in any way. The examples do not include detailed descriptions of conventional methods. WeClaim: 1. A process for preparing olmesartan medoxomil comprising: a) contacting trityl olmesartan medoxomil with an acid of the kind such as herein described in a water miscible organic solvent of the kind such as herein described to obtain a solution of olmesartan medoxomil and a precipitate of triphenyl carbinol; b) separating the precipitate of triphenyl carbinol from the solution of olmesartan medoxomil; c) contacting the solution of olmesartan medoxomil with a base to obtain a precipitate of olmesartan medoxomil; and d) recovering olmesartan medoxomil. 2. The process as claimed in claim 1, wherein the trityl olmesartan medoxomil is contacted with the water miscible organic solvent and water. 3. The Process as claimed in claim 2, wherein the ratio of water to the water miscible organic solvent is 1:3 to 3:1 by volume. 4. The process as claimed in claim 1, wherein the water miscible organic solvent is selected from the group consisting of acetone, acetonitrile, and t-butanol. 5. The process as claimed in claim 4, wherein the water miscible organic solvent is acetone. 6. The process as claimed in claim 5, wherein the trityl olmesartan medoxomil is contacted with acetone and water, and the ratio of water to acetone is 1:3 to 3:1 by volume. 7. The process as claimed in claim 1, wherein the acid has a pH of 0 to 4. 8. The process as claimed in claim 1, wherein the acid is selected from the group consisting of sulfuric acid, hydrochloric acid, and p-toluene sulfonic acid. 9. The process as claimed in claim 8, wherein the acid is sulfuric acid. 10. The process as claimed in claim 1, wherein the amount of acid is 2 to 8 equivalents. 11. The process as claimed in claim 10, wherein the amount of acid is 3 equivalents. 12. The process as claimed in claim 1, wherein step a) is performed at a temperature of 10°C to 60°C. 13. The process as claimed in claim 12, wherein step a) is performed at 40°C. 14. The process as claimed in claim 1, wherein prior to step b), the solution of olmesartan medoxomil is maintained for 3 to 15 hours. 15. The process as claimed in claim 14, the solution of olmesartan medoxomil is maintained for 4 to 6 hours. 16. The process as claimed in claim 15, wherein the solution of olmesartan medoxomil is maintained for 4 hours. 17. The process as claimed in claim 1, further comprising adding water prior to step b). 18. The process as claimed in claim 17, wherein the amount of added water is 2 volumes per gram of trityl olmesartan medoxomil. 19. The process as claimed in claim 1, wherein the base is selected from the group consisting of potassium carbonate and sodium bicarbonate. 20. The process as claimed in claim 19, wherein the base is sodium bicarbonate. 21. The process as claimed in claim 1, wherein the amount of base used is 0.8 to 1.5 equivalents compared to the amount of acid used. 22. The process as claimed in claim 1, wherein step c) is performed at a temperature of 2°C to 25°C. 23. The process as claimed in claim 22, wherein step c) is performed at room temperature.

Full Text

The present invention relates to a process for preparing olmesartan medoxomil.
This application claims the benefit of U.S. Provisional Patent Application Ser. No. 60/606,437 filed September 2,2004.
FIELD OF INVENTION
The present invention relates to processes for preparing olmesartan medoxomil.
BACKGROUND OF THE INVENTION
The chemical name for olmesartan medoxomil is 4-(l-hydroxy-l-methylethyl)-2-propyl-l-[[2'-(lH-tetrazol-5-yl)[l,r-biphenyl]-4-yl]methyl]-lH-irnidazole-5-carboxylic acid (5-methyl-2-oxo-l,3-dioxol-4-yl)methyl ester (Merck Index 13th ed.). The chemical structure of olmesartan medoxomil is:
(Formula Removed)
The empirical formula is C29H30N6O6.
The molecular weight is 558.58.
Olmesartan medoxomil is a prodrug that is hydrolyzed during absorption, and it is a selective AT) subtype angiotensin II receptor antagonist. Olmesartan medoxomil is disclosed by U.S. Patent No. 5,616,599 to Yanagisawa et al. It is marketed as BENICAR® in film-coatqd tablets of 5 mg, 20 mg, and 40 mg for treatment of hypertension in a human.
The synthesis of olmesartan medoxomil (OLM-Mod)per se is illustrated as follows (see also Annu. Rep. Sankyo Res. Lab 2003, 55, 1-91):

(Figure Remove)

The prior art synthetic methods focus on the coupling between the substituted imidazole and the substituted biphenyl methylene bromide. Additional synthetic methods for these olmesartan medoxomil intermediates are described by: JP 11302260, JP 11292851, JP 07053489, JP 06298683, US 5621134, EP 838458, DE 19757995, US 6111114, and US 6214999.
Step (vi) (the deprotection step) of the prior art synthesis is illustrated as follows:

(Figure Remove)

MTT

OLM-M od crude

Example 61(b) of the '599 patent discloses a process for preparing crude olmesartan medoxomil from a mixture of trityl olmesartan medoxomil (MTT) and aqueous acetic acid.
Col. 176, lines 24-37. Triphenyl carbinol (TPC) is removed, and ohnesartan medoxomil is isolated by evaporation.
in solution
MTT acetScacid > OLM-Mod + TPC .-» OLM-Mod evaPoratio^ OLM-Mod crude
f 1 H2O TPC
Because of the acidic conditions and the presence of water, the impurity OLM-acid is also formed during the reaction by hydrolysis of the ester bond. The prior art process yields crude ohnesartan medoxomil containing 2.2% OLM-acid per area percent HPLC.
There is a need for improved processes for preparing ohnesartan medoxomil.
SUMMARY OF THE INVENTION
In one aspect, the present invention provides a process for preparing ohnesartan medoxomil including the steps of: contacting trityl ohnesartan medoxomil with an acid in a water miscible organic solvent, with or without water, preferably acetone and water, to obtain a solution of ohnesartan medoxomil and a precipitate of triphenyl carbinol; separating the precipitate of triphenyl carbinol from the solution of olmesartan medoxomil; and contacting the solution of olmesartan medoxomil with a base to obtain a precipitate of ohnesartan medoxomil.
DETAILED DESCRIPTION OF THE INVENTION
The present invention provides a process for preparing ohnesartan medoxomil including the steps of: contacting trityl ohnesartan medoxomil with an acid in a water miscible organic solvent, with or without water, to obtain a solution of ohnesartan medoxomil and a precipitate of triphenyl carbinol; separating the precipitate of triphenyl carbinol from the solution of ohnesartan medoxomil; and contacting the solution of olmesartan medoxomil with a base to obtain a precipitate of ohnesartan medoxomil.
Preferred water miscible organic solvents include, but are not limited to, acetone, acetonitrile, and t-butanol. Acetone is especially preferred. Preferably, the trityl ohnesartan medoxomil is contacted with a mixture of a water miscible organic solvent and water. Most preferably, the trityl olmesartan medoxomil is contacted with a mixture of acetone and water. Preferably, the ratio of water to the water miscible organic solvent, e.g., acetone, is preferably about 1:3 to about 3:1 by volume.
The acid that is contacted with the trityl ohnesartan medoxomil removes the triphenyl carbinol to form an acid salt of olmesartan medoxomil. Preferably, the acid is a strong acid

having a pH of about 0 to about 4. Suitable acids include, but are not limited to, organic acids such as formic acid, acetic acid, benzoic acid, and oxalic acid; oxoacids such as perchloric acid, chloric acid, chlorous acid, hypochlorous acid, sulfuric acid, sulfurous acid, p-toluene sulfonic acid, nitric acid, nitrous acid, phosphoric acid, and carbonic acid; and binary acids such as hydrofluoric acid, hydrochloric acid, hydrobromic acid, hydrocyanic acid, and hydrosulfuric acid. Hydrochloric acid, p-toluene sulfonic acid, and especially sulfuric acid are preferred. Preferably, the amount of acid is about 2 to about 8 equivalents, more preferably about 3 to about 4 equivalents, and most preferably about 3 equivalents.
When contacting the trityl olmesartan medoxomil with the acid, the temperature is preferably about 10°C to about 60°C, more preferably about 40°C. In a preferred embodiment, the combination of trityl olmesartan medoxomil, the water miscible organic solvent, and the acid is maintained for about 3 to about 15 hours. Preferably, the combination is maintained for about 4 to about 6 hours, most preferably for about 4 hours.
In a preferred embodiment, prior to separating the triphenyl carbinol, water is added to avoid the formation of undesired by-products. Preferably, the amount of added water is about 2 volumes per gram of trityl olmesartan medoxomil. Precipitation can be perceived visually as a clouding of the solution or formation of distinct particles of the precipitate suspended in the solution or collected at the bottom the vessel containing the solution.
Separating the triphenyl carbinol from the solution can be performed by any means known in the art, such as filtration or centrifugation.
After separating the triphenyl carbinol, the olmesartan medoxomil solution is contacted with a base. Suitable bases include, but are not limited to, alkali and alkaline earth metal hydroxides, carbonates, and hydrogen carbonate salts. Specific exemplary bases include, but are not limited to, sodium hydroxide, potassium hydroxide, calcium hydroxide, magnesium hydroxide, sodium carbonate, potassium carbonate, sodium bicarbonate, potassium bicarbonate, and calcium carbonate. Potassium carbonate and especially sodium bicarbonate are preferred. Preferably, the equivalents of base used is about equal to the equivalents of acid used, that is, the amount of base used is preferably about 0.8 to 1.5 equivalents compared to the amount of acid used. The base preferably increases the pH of the solution, but the solution need not reach a basic pH. After contacting the solution with the base, the solution is preferably maintained at a temperature of about 2°C to about 25'C, preferably at about room temperature. As used herein, the term "room temperature" refers to a temperature of about 20°C to 30°C, preferably 20°C to 25°C. The solution is maintained until olmesartan medoxomil is precipitated.

The precipitate of olmesartan medoxomil can then be recovered by any means known in the art, such as filtration or centrirugation. Olmesartan medoxomil is recovered in its free base form, i.e., the nitrogen on the tetrazole is free.
The reaction progress can be detected by any method known in the art, such as, for example, HPLC, GC, TLC, NMR, and mass spectroscopy.
An exemplary embodiment of the present invention is depicted by the folio whig scheme:
(Figure Remove)

By using the process of the present invention, olmesartan medoxomil can be obtained directly, without the evaporation step required by the prior art process, which is an inconvenient industrial method. See U.S. Patent No. 5,616,599 Example 61(b). Also, the product of the '599 process is obtained in a gel-like form, which is difficult to handle in an industrial process. In addition to presenting industrial disadvantages, the '599 process achieves a lower yield than that obtained by the present invention. Additionally, the olmesartan medoxomil obtained according to the present invention has a lower amount of the impurity olmesartan acid (OLM-acid). Crude olmesartan medoxomil prepared according to the '599 process contains 2.2% OLM-acid. hi contrast, crude olmesartan medoxomil prepared according the present invention contains less than about 1% OLM-acid, e.g., only about 0.89% OLM-acid. All percentages of impurities described herein are provided as area percentage HPLC at 220 nm.
EXAMPLES
Examplp 1: Preparation of olmesartan medoxomil
A 250 round bottom flask was charged with MTT (10 g), acetone/water (2/2 vol.), and 3 eq of H2S04. The combination was stirred at room temperature for about 4-6 hrs. Triphenyl carbinol (TPC) was precipitated by adding water and filtered out. NaHCOa was added to the filtrate, and the mixture was cooled to 5°C and stirred for 1 hr. Crude olmesartan medoxomil was obtained as white crystals (90% yield).
Example 2: Preparation of crude olmesartan medoxomil

A 1L reactor, equipped with mechanical stirrer and thermometer, was charged with MTT (70 g), acetone (140 ml), water (140 ml), and H2SO4 (19.47 g). The reactor was heated to 40°C for 2.5 hrs (at EOR, MTT is LT 1%). Water (140 ml) was added at 40°C, and the reaction was stirred for 1.5 hrs or until MTT is LT 0.1%. After cooling to 15°C and stirring for 1 hr, the TPC was filtered and washed with water (70 ml).
NaHCOs was added in portions to the filtrate at room temperature. The reaction mixture was stirred for 1 hr, then filtrated, and the cake was washed with water (140 ml). The solid was dried at 45°C in a vacuum oven overnight to obtain crude OLM-Mod (98 % yield).
Having thus described the invention with reference to particular preferred embodiments and illustrative examples, those in the art can appreciate modifications to the invention as described and illustrated that do not depart from the spirit and scope of the invention as disclosed in the specification. The examples are set forth to aid in understanding the invention but are not intended to, and should not be construed to, limit its scope in any way. The examples do not include detailed descriptions of conventional methods.

WeClaim:
1. A process for preparing olmesartan medoxomil comprising:
a) contacting trityl olmesartan medoxomil with an acid of the kind such as herein described in a water miscible organic solvent of the kind such as herein described to obtain a solution of olmesartan medoxomil and a precipitate of triphenyl carbinol;
b) separating the precipitate of triphenyl carbinol from the solution of olmesartan medoxomil;
c) contacting the solution of olmesartan medoxomil with a base to obtain a precipitate of olmesartan medoxomil; and
d) recovering olmesartan medoxomil.

2. The process as claimed in claim 1, wherein the trityl olmesartan medoxomil is contacted with the water miscible organic solvent and water.
3. The Process as claimed in claim 2, wherein the ratio of water to the water miscible organic solvent is 1:3 to 3:1 by volume.
4. The process as claimed in claim 1, wherein the water miscible organic solvent is selected from the group consisting of acetone, acetonitrile, and t-butanol.
5. The process as claimed in claim 4, wherein the water miscible organic solvent is acetone.
6. The process as claimed in claim 5, wherein the trityl olmesartan medoxomil is contacted with acetone and water, and the ratio of water to acetone is 1:3 to 3:1 by volume.
7. The process as claimed in claim 1, wherein the acid has a pH of 0 to 4.
8. The process as claimed in claim 1, wherein the acid is selected from the group consisting of sulfuric acid, hydrochloric acid, and p-toluene sulfonic acid.
9. The process as claimed in claim 8, wherein the acid is sulfuric acid.
10. The process as claimed in claim 1, wherein the amount of acid is 2 to 8 equivalents.

11. The process as claimed in claim 10, wherein the amount of acid is 3 equivalents.
12. The process as claimed in claim 1, wherein step a) is performed at a temperature of 10°C to 60°C.
13. The process as claimed in claim 12, wherein step a) is performed at 40°C.
14. The process as claimed in claim 1, wherein prior to step b), the solution of olmesartan medoxomil is maintained for 3 to 15 hours.
15. The process as claimed in claim 14, the solution of olmesartan medoxomil is maintained for 4 to 6 hours.
16. The process as claimed in claim 15, wherein the solution of olmesartan medoxomil is maintained for 4 hours.
17. The process as claimed in claim 1, further comprising adding water prior to step b).
18. The process as claimed in claim 17, wherein the amount of added water is 2 volumes per gram of trityl olmesartan medoxomil.
19. The process as claimed in claim 1, wherein the base is selected from the group consisting of potassium carbonate and sodium bicarbonate.
20. The process as claimed in claim 19, wherein the base is sodium bicarbonate.
21. The process as claimed in claim 1, wherein the amount of base used is 0.8 to 1.5 equivalents compared to the amount of acid used.
22. The process as claimed in claim 1, wherein step c) is performed at a temperature of 2°C to 25°C.
23. The process as claimed in claim 22, wherein step c) is performed at room temperature.

Documents:

7869-DELNP-2006-Abstract (25-09-2009).pdf

7869-delnp-2006-abstract.pdf

7869-DELNP-2006-Claims (25-09-2009).pdf

7869-delnp-2006-claims.pdf

7869-DELNP-2006-Correspondence-Others (25-09-2009).pdf

7869-DELNP-2006-Correspondence-Others-(08-07-2009).pdf

7869-DELNP-2006-Correspondence-Others.pdf

7869-DELNP-2006-Description (Complete) (25-09-2009).pdf

7869-delnp-2006-description (complete).pdf

7869-DELNP-2006-Form-1 (25-09-2009).pdf

7869-delnp-2006-form-1.pdf

7869-delnp-2006-form-18.pdf

7869-DELNP-2006-Form-2 (25-09-2009).pdf

7869-delnp-2006-form-2.pdf

7869-DELNP-2006-Form-3-(08-07-2009).pdf

7869-DELNP-2006-Form-3.pdf

7869-delnp-2006-form-5.pdf

7869-DELNP-2006-GPA (25-09-2009).pdf

7869-delnp-2006-gpa.pdf

7869-DELNP-2006-Others-Documents-(08-07-2009).pdf

7869-delnp-2006-pct-220.pdf

7869-DELNP-2006-PCT-237-(08-07-2009).pdf

7869-delnp-2006-pct-237.pdf

7869-delnp-2006-pct-304.pdf

7869-DELNP-2006-PCT-308.pdf

7869-DELNP-2006-PCT-373-(08-07-2009).pdf

7869-delnp-2006-pct-search report.pdf

7869-DELNP-2006-Petition-137 (25-09-2009).pdf

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Patent Number

265545

Indian Patent Application Number

7869/DELNP/2006

PG Journal Number

10/2015

Publication Date

06-Mar-2015

Grant Date

27-Feb-2015

Date of Filing

26-Dec-2006

Name of Patentee

TEVA PHARMACEUTICALS INDUSTRIES LTD

Applicant Address

5 BASEL STREET, P.O.BOX 3190, PETAH TIQVA 49131, ISRAEL

Inventors:

#	Inventor's Name	Inventor's Address
1	LILACH HEDVATI	EIN-SHEMER, DOAR NA HEFER, 37845, ISRAEL
2	GIDEON PILARSKY	12/29 ATAROTH, HOLON ISRAEL 58487

PCT International Classification Number

C07D 403/10

PCT International Application Number

PCT/US2005/031481

PCT International Filing date

2005-09-02

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1	60/606,437	2004-09-02	U.S.A.