Title of Invention	2-(1H-INDOLYLSULFANYL)-ARYL AMINE DERIVATIVES
Abstract	2-(lH-INDOLYLSULFANYL)-ARYL AMINE DERIVATIVES The present invention relates to compounds of formula IV (IV) and their use.

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2-(lH-Indolylsulfanyl)-aryl amine derivatives FIELD OF THE INVENTION The present invention relates to compounds of formula IV and the medical use thereof e.g. in the treatment of affective disorders, pain disorders, attention deficit hyperactivity disorder (ADHD) and stress urinary incontinence. BACKGROUND OF THE INVENTION The majority of currently available antidepressants can be classified in 3 classes: 1) monoamine oxidase inhibitors (MAOIs), 2) biogenic amine neurotransmitter [serotonin (5-HT), norepinephrine (NE) and dopamine (DA)] transporter reuptake blockers, and 3) modulators, especially blockers of one or more of the 5-HT and/or NE receptors. Since depression is associated with a relative deficiency of the biogenic amines, the use of 5-HT and/or NE-receptor blockers (i-e. 5-HT and or NE-antagonist's) have not proven very successful in the treatment of depression and anxiety and the preferred and currently most efficacious treatments are based on the enhancement of 5-HT and/or NE neurotransmission by blocking their reuptake back from the synaptic cleft (Slattery, D.A, et al., "The evolution of antidepressant mechanisms",fundamentaland Clinical pharmacology, 2004, 18, 1-21; Schloss, P. et al, "new insights into the mechanism of antidepressant therapy", Pharmacology and therapeutics, 2004, 102,47-60). Selective serotonin reuptake inhibitors (hereinafter referred to as SSRIs) have become first choice therapeutics in die treatment of depression, certain forms of anxiety and social phobias, because they generally are effective, well tolerated and have a favourable safety profile compared to the classic tricyclic antidepressants. Drugs claimed to be SSRIs are for example fluoxetine, sertraline and paroxetine. However, clinical studies on depression indicate that non-response to the known SSRIs is substantial, up to 30%. Another, often neglected, factor in the treatment of depression is the delay in the onset of the therapeutic effect of the SSRIs. Sometimes symptoms even worsen during the first weeks of treatment. Furthermore, sexual dysfunction is generally a side effect common to SSRIs. Accordingly, there is a desire for the development of compounds capable of improving the treatment of depression and other diseases related to malfunctioning of serotonin. Dual re-uptake inhibitors providing the combined effect of 5-HT reuptake inhibition and NE (norepinephrine is also named noradrenaline, NA) reuptake inhibition on depression is explored in clinical studies of compounds such as Duloxetine (Wong, "Duloxetine (LY-248686): an inhibitor of serotonin and noradrenaline uptake and an antidepressant drug candidate". Expert Opinion on Investigational Drugs, 1998, 7, 10, 1691-1699) and Venlafaxine (Khan-A et al, 30 "Venlafaxine in depressed outpatients", Psychophannacology Bulletin, 1991,27, 141-144). Compounds having such dual effect are also named SNRIs, "serotonin and noradrenaline reuptake inhibitors", or NSRIs, "noradrenaline and serotonin reuptake inhibitors". Since treatment with the selective NE reuptake inhibitor reboxedne has been shown to stimulate 5-HT neurons and mediate the release of 5-HT in the brain (Svensson,T. et al, J. Neural Transmission, 2004, 111, 127) there might be a synergistic advantage using SNRI's in the treatment of depression or anxiety. The use of SNRI's have been shown in clinical studies to have a beneficial effect on pain (e.g. Fibromyalgia syndrome, overall pain, back pain, shoulder pain, headache, pain while awake and during daily activities) and especially pain associated with depression (Berk, M. Expert Rev. Neurotherapeutics 2003, 3,47-451; Fishbain, D.A., et al. "Evidence-based data from animal and human experimental studies on pain relief with antidepressants: A structured review" Pain Medicine 2000 1:310"316). SNRI's have also been shown in clinical studies to have a beneficial effect in attention deficit hyperactivity disorder (ADHD) (N. M. Mukaddes; Venlafaxine in attention deficit hyperactivity disorder, European Neuropsychopharmacology, Volume 12, Supplement 3, October 2002, Page 421). Furthermore, SNRFs have been shown to be effective for the treatment of stress urinary incontinence (Dmochowski R.R. et al. "Duloxetine versus placebo for the treatment of North American women with stress urinary incontinence"'. Journal of Urology 2003,170:4, 1259-1263.) Naranjo, C. etal " The role of the brain reward system in depression" Prog. Neuro-Psychophannacol Biol Psychiatry 2001,25, 781- 823 discloses clinical and preclinical findings of links between lack of extra cellular dopamine in the mesocorticolimbic system and anhedonia, which is one of the main symptoms of depression, Wellbutrin (bupropion) which has DA re-uptake activity in vitro and in vivo, shows antidepressant efficacy. Other combination studies have indicated that addition of some affinity at the DA uptake site may have some clinical benefit (Nelson, J. C. J. Clin. Psychiatry 1998, 59, 65; Masand, P. S. et al. Depression Amiety 1998, 7, 89; Bodkin, J. A et al. J, Clin, Psychiatry 1997, 58, 137). Axford L. et al. (2003, Bioorganic & Medical Chemistry Letters, 13, 3277-3280: "Bicyclo[2.2. l.]heptanes as novel triple re-uptake inhibitors for the treatment of depression") describe the development of triple 5-HT, NE and DA re-uptake inhibitors for treatment of depression. The combination of an SSRI and a norepinephrine and dopamine reuptake inhibitor, has been shown to have better efficacy in SSRI-non-responders (Lara R. W. et al "Citalopram and Bupropion-SR: Combining Versus Switching in Patients With Treatment-Resistant Depression."/. Clin, Psychiatry 2004, 65, 337-340). There is clinical evidence suggestmg the combination of an SSRI and a norepinephrine and dopamine reuptake inhibitor induces less sexual dysfunction, than treatment with SSRFs alone (Kennedy S. H. et al. " Combining Bupropion SR With Venlafaxine, Paroxetine, or Duloxetine: A Preliminary Report on Pharmacokinetic, Therapeutic, and Sexual Dysfunction Effects" 7. Clin. Psychiatry 2002,63, 181-186). Diphenyl sulphides of formula I and variations thereof have been disclosed as serotonin reuptake inhibitors and have been suggested for use in treatment of depression, cf. e.g. WO03029232(Al). Diphenyl sulphides of formula II and variations thereof have been disclosed as serotonin reuptake inhibitors and have been suggested for use in treatment of depression, cf, e.g. US 5095039, US 4056632, EP 396827 Al and WO 9312080. EP 402097 describes halogen substituted diphenylsulfides claimed to be selective serotonin inhibitors for treatment of depression. Likewise WO 9717325 disclose derivatives of N,N-dimethyl-2-(arylthio)benzylamine claimed to be selective serotonin transport inhibitors and suggest their use as antidepressants. J. Jilek et al,, Collect Czeck Chem, Commun. 1989, 54, 3294-3338 also discloses various derivatives of diphenyl sulphides, "phenyl-thio-benzylamines" as antidepressants. Furthermore, diphenyl sulphides are also disclosed in US 3803143 and claimed useful as antidepressant. K. Sindelar et al., (K. Sindelar et al. Collect, Czeck Chem, Comrnun, 1991,56, 449-458) disclose compounds of formula HI with test for selectivity as 5-HT re-uptake inhibitor and NA re-uptake inhibitor, respectively, for use as antidepressants. The above-mentioned references do not disclose compounds comprising an indole group like the indolyl-sulfanyl arylamines of the present invention. The present invention provides 2-(lH-indolylsulfanyl)-aryl amine derivatives of formula IV which are serotonin reuptake inhibitors. A particular aspect of the invention provides compounds possessing the combined effect of serotonin reuptake inhibition and norepinephrine reuptake inhibition. Another particular aspect of the invention provides compounds possessing the combined effect of serotonin reuptake inhibition and dopamine reuptake inhibition. Furthermore, some of the compounds are also triple 5-HT, NE and DA re-uptake inhibitors. wherein X, Y, Z, Q, m, n, o, p and R^-R^"^ are as defined below. SUMMARY OF THE INVENTION One object of the invention is the provision of compounds, which are serotonin reuptake inhibitors. Another object of the invention is the provision of compounds, which are both serotonin reuptake inhibitors and noradrenaline reuptake inhibitors. Yet another object of the invention is the provision of compounds, which are both serotonin reuptake inhibitors and dopamine reuptake inhibitors. Yet another object of the invention is the provision of compounds, which are serotonin reuptake inhibitors, noradrenaline reuptake inhibitors and dopamine reuptake inhibitors. The compounds of the invention are substituted indole derivatives of the general formula IV as the free base or salts thereof. The invention provides a compound according to the above for use as a medicament. The invention provides a pharmaceutical composition comprising a compound according to the above and at least one pharmaceutically acceptable carrier or diluent. The invention provides the use of a compound according to the above for the preparation of a pharmaceutical composition for the treatment of affective disorders, pain disorders, ADHD and stress urinary incontinence. The invention furthermore concerns the use of a compound according to the above in a method of treatment of affective disorders, pain disorders, ADHD and stress urinary incontinence. DEFINITION OF SUBSTTTUENTS The term heteroatom refers to a nitrogen, oxygen or sulphur atom. Halo means halogen. Halogen means fluoro, chloro, bromo or iodo. The expression- "'C1-6"alk(en/yn)yr' means a C1-6-alkyl, a C2.6"alkenyl or a C2-6-alkynyl group. The term "C1-6-alkyI" refers to a branched or unbranched alkyl group having from one to six carbon atoms inclusive, including but not limited to methyl, ethyl, 1-propyl, 2-propyl, 1-butyl, 2-butyl, 2-methyl-2-propyl and 2-methyl-l-propyl. The term "C2-6-alkenyl" refers to a branched or unbranched alkenyl group having from two to six carbon atoms, including one double bond, including but not limited to ethenyl, propenyl, and butenyl. The term "C2-6-alkynyl" refers to a branched or unbranched alkynyl group having from two to six carbon atoms, including one triple bond, including but not limited to ethynyl, propynyl and butynyl. The expression "C3-8"Cycloalk(en)yl" means a C3-8-cycloalkyl or a C3-8-cycloalkenyl group. The term "C3-8-cycloalkyl" designates a monocyclic or bicyclic carbocycle having three to eight C-atoms, including but not limited to cyclopropyl, cyclopentyl, and cyclohexyl. The term "C3-8-cycloalkenyl" designates a monocyclic or bicyclic carbocycle having three to eight C-atoms and one double bond, including but not limited to cyclopropenyl, cyclopentenyl and cyclohexenyl. In the expression "C3.8-cycloalk(en)yl-C1-6"alk(en/yn)yI", "C1-6-alk(en/yn)yIamino", "di-(C1-6-alk(en/yn)yl)amino", "C1-6-alk(en/yn)ylcarbonyr', "C1-6-alk(en/yn)ylaminocarbonyl","di"(Cu6-alk(en)yI)aminocarbonyl", "C1-6-alk(en/yn)yloxy", "C1-6-alk(en/yn)ylsulfanyl", "halo-C1-6'-alk(en/yn)yl", "halo--alk(en/yn)ylsulfonyr'. "halo-C1-6-aIk(en/yn)ylsulfanyl" and "C1-6-alk(en/yn)ylsulfonyl" the terms "amino", "C3.8-cycloalk(en)yl". "C1-6-alk(en/yn)yr\ "C1-6-alk(en)yl" and "halo" are as defined above. The term "aminocarbonyl" designates NH2-C=0 which is attached to the remainder of the molecule via the carbon atom. The term "R1 and R1 together with the nitrogen form a 4-7 membered ring containing zero or one double bond, optionally said ring in addition to said nitrogen comprises one further heteroatom selected from oxygen and sulphur" refers to such ring systems wherein a ring is formed by the nitrogen to which R" and R1 are attached and 3-6 atoms selected from 2-6 carbonatoms and O-I heteroatoms selected from sulphur and oxygen, said ring contains zero or one double bond.-Examples of rings formed by R\ R" and the nitrogen to which they are attached are pyrrolidine, piperidine, morpholine and thiomorpholine.. DESCRIPTION OF THE INVENTION The present invention relates to a compound represented by the general formula IV wherein R -R1 are independently selected from hydrogen,C1-6-alk(en/yn)yl, C3.8-cycloalk(en)yl, and C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl; or R1 and R1 together with the nitrogen form a 4-7 membered ring containing zero or one double bond, optionally said ring in addition to said nitrogen comprises one further heteroatom selected from oxygen and sulphur; R3R1 and R1-R11 are independently selected from hydrogen, halogen, cyano, nitro, C1-6-alk(en/yn)yl, C3-8-cycloalk(en)yl, C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, amino, C1-6-alk(en/yn)ylamino, di-(C1-6-alk(en/yn)yl)amino, C1-6-alk(en/yn)ylcarbonyl, aminociarbonyl, C1-6"alk(en/yn)ylaminocarbonyl, di-(C1-6-aIk(en/yn)yl)aminocarbonyl, hydroxy, C1-6-alk(en/yn)yloxy, C1-6"alk(en/yn)ylsulfanyl, halo-C1-6-alk(en/yn)yl, halo- C1-6-alk(en/yn)ylsulfonyl, halo-C1-6-alk(en/yn)yIsuIfanyl and C1-6-alk(en/yn)ylsulfonyl; R1 is selected from hydrogen, C1-6-alk(en/yn)yl, C3.8-cycloalk(en)yl and C3.8-cycloalk(en)yl- C1-6-alk(en/yn)yl; X is selected from the group consisting of CH2. CHR1'or CR1'R1' Y is selected from the group consisting of CH2, CHR1'and CR1'R1' Z is selected from the group consisting of CH2, CHR1'and CR1'R1'and Q is selected from the group consisting of CH2, CHR1'and CR1'R1'; m, n, o and p are independently 0 or 1 with the proviso that when m+ n + o + p equals to 1 then none of X, Y, Z and Q are CH2; wherein R1'- R1 are independently selected from the group consisting of C1-6-alk(en/yn)yl, C3-8-cycloalk(en)yl- and C3.8-cycloalk(en)yl-Gi.6-alk(en/yn)yl-; . . . . as the free base or a salt thereof. In one embodiment of the compound of formula IV, R1 and R1 are independently selected from the group consisting of C3.8-cycloalk(en)yI and C3.8-cycloalk(en)yl-C1-6-alk(en/yn)yl. In a further embodiment of the compound of formula IV, R and R are independently selected from the group consisting of hydrogen and C1-6-alk(en/yn)yl; or R1 and R1 together with the nitrogen form a 4-7 membered ring containing zero or one double bond, optionally said ring in addition to said nitrogen comprises one further heteroatom selected from oxygen and sulphur. To further illustrate without limiting the invention an embodiment of R1 is hydrogen; another embodiment of R1 is C1-6-alk(en/yn)yl such as methyl. To further illustrate without limiting the invention an embodiment of R1 is hydrogen; another embodiment of R1 is C1-6-alk(en/yn)yl such as methyl. To further illustrate without limiting the invention, an embodiment of the compound of formula IV concerns such compounds wherein R1 and R1 together with the nitrogen form a 4-7 membered ring containing zero or one double bond, optionally said ring in addition to said nitrogen comprises one further heteroatom selected from oxygen and sulphur. In one embodiment said 4-7 membered ring does not contain any double bond; in another ' embodiment said 4-7 membered ring does contain one double bond. In one embodiment the only heteroatom contained in said 4-7 membered ring is the nitrogen to which R1 and R" are attached. In another embodiment said 4-7 membered ring contains one heteroatom in addition to the nitrogen to which R1 and R1 are attached; in a further embodiment said heteroatom is sulphur; in a further embodiment said heteroatom is oxygen. Typically said 4-7 membered ring is selected from the group consisting of morpholine and thiomorpholine. In a further embodiment of the compound of formula IV, R1-R1 and R1-R1'are independently selected from the group consisting of C1-6-alk(en/yn)ylcarbonyl, aminocarbonyl, C1-6-alk(en/yn)ylaminocarbonyl, di-(C1-6-alk(en/yn)yl)aminocarbonyl and hydroxy. "i /L RIO In a further embodiment of the compound of formula IV, R" -R and R -R are independently selected from the group consisting of hydrogen, halogen, cyano, nitro, C!-6-alk(en/yn)yl, C3.8-cycIoalk(en)yI, C3.8-cycloalk(en)yl-C1-6-alk(en/yn)yl, amino, C1-6-alk(en/yn-)ylamino, aminoC1-6-alk(en/yn)yloxy,-C1-6-alk(en/yn)ylsulfanyl, halo'C1-6-alk(en/yn)yl, halo-C1-6-alk(en/yn)ylsulfonyl, halo-C1-6-alk(en/yn)ylsulfanyl and C i.6"alk(en/yn)ylsulfonyl In a further embodiment of the compound of formula IV, R1-R1 and R1-R1'are independently selected from the group consisting of hydrogen, halogen, nitro, C1-6-alk(en/yn)yl, di-(C1-6-alk(en/yn)yl)amino, C1-6-alk(en/yn)yloxy and C1-6-alk(en/yn)ylsulfonyl. In a further embodiment of the compound of formula IV, R -R and R -R " are independently selected from the group consisting of hydrogen, halogen, C1-6"alk(en/yn)yl, and C1-6"aIk(en/yn)yloxy. In an embodiment of the compound of formula IV, R1-R1 are independently selected from the group consisting of nitro, amino, C1-6-alk(en/yn)ylamino, di-(C1-6-alk(en/yn)yl)amino, C1-6-alk(en/yn)ylcarbonyl, aminocarbonyl, C1-6-alk(en/yn)ylaminocarbonyl, di-(C1-6-alk(en/yn)yl)aminocarbonyl, hydroxy, halo-C1-6"alk(en/yn)ylsulfonyl and C 1- .6-alk(en/yn)ylsulfonyl. In a further embodiment of the compound of formula IV, R1-R1 are independentiy selected from the group consisting of hydrogen, halogen, cyano, C1-6-alk(en/yn)yl, C3-8-cycioaIk(en)yI, C3-8-cycloaIk(en)yl-C1-6-alk(en/yn)yl, halo-C1-6-aIk(en/yn)yl, C1_6-alk(en/yn)yloxy, C1-6-alk(en/yn)ylsulfanyl and halo-C1-6-alk(en/yn)ylsulfanyL Typically, R1-R1 are independently selected from the group consisting of hydrogen, halogen and C1-6-alk(en/yn)yloxy. To further illustrate without limiting the invention an embodiment of R is hydrogen. Typically, R"" is selected from the group consisting of hydrogen, halogen and C1-6-alk(en/yn)yloxy. To further illustrate without limiting the invention an embodiment of R"" is hydrogen; another embodiment of R'is halogen such as chloro or fluoro; another embodiment of R"'is C1-6"alk(en/yn)yloxy such as methoxy. Typically, R1 is selected from the group consisting of hydrogen and C1-6-alk(en/yn)yloxy. To further illustrate without limiting the invention an embodiment of R1 is hydrogen; another embodiment of R1 is C1-6-alk(en/yn)yloxy such as methoxy. To further illustrate without limiting the invention an embodiment of R1 is hydrogen. In a further embodiment of the compound of formula IV, R1-R1'are independentiy selected from the group consisting of Gi-6-alk(en/yn)ylcarbonyl, aminocarbonyl; - C1-6-alk(en/yn)ylaminocarbonyl, di-(C1-6-alk(en/yn)yl)aminocarbonyl and hydroxy. In a further embodiment of the compound of formula IV, R1-R1'are independentiy selected from the group consisting of hydrogen, halogen, cyano, nitro, C1-6-alk(en/yn)yl, C3_8-cycloalk(en)yl, C3.8-cycloalk(en)yl-C1-6-alk(en/yn)yl, amino, C1-6-alk(en/yn)ylamino, di-(C1-6-alk(en/yn)yl)amino, C1-6-alk(en/yn)yloxy, C1-6-'alk(en/yn)ylsulfanyl, halo- C1-6-alk(en/yn)yl, halo-C1-6"alk(en/yn)ylsulfonyl, halo-C1-6-alk(en/yn)ylsulfanyl and C1.6-alk(en/yn)ylsulfonyl; Typically, R1-R1'are independentiy selected from the group consisting of hydrogen, halogen, nitro, C1-6-alk(en/yn)yl, di-(C1-6-alk(en/yn)yl)amino, C1-6-alk(en/yn)yloxy and C1-6-alk(en/yn)ylsulfonyl. In a further embodiment of the compound of formula IV, R1-R1'are independently selected from the group consisting of hydrogen, halogen, C1-6-alk(en/yn)yl and C1-6-alk(en/yn)yloxy. Typically, R is selected from the group consisting of hydrogen, halogen and C1-6-alk(en/yn)yloxy. To further illustrate without limiting the invention an embodiment of R is hydrogen; another embodiment of R is halogen such as chloro or fluoro; another embodiment of R1 is C1-6-aIk(en/yn)yloxy such as methoxy. Typically, R1 is selected from the group consisting of hydrogen, halogen, C1-6-alk(en/yn)yl and di-(C1-6-alk(en/yn)yl)amino. To further illustrate without limiting the invention an embodiment of R1 is hydrogen; another embodiment of R1 is halogen such as chloro or fluoro; another embodiment of R1 is C1-6-alk(en/yn)yl such as methyl; another embodiment of R1 is di-(C1-6-aIk(en/yn)yl)amino such as diraethylamino. Typically, R'"'is selected from the group consisting of hydrogen, halogen and C1-6-alk(en/yn)ylsulfonyl. To further illustrate without limiting die invention an embodiment of R1° is hydrogen; another embodiment of R1"'is halogen such as fluoro; another embodiment of R1'is C1-6-alk(en/yn)ylsulfonyl such as raethylsulfonyl. Typically, R1'is selected from the group consisting of hydrogen, halogen, nitro and C1-6-alk(en/yn)yloxy. To further illustrate without limiting the invention an embodiment of R1 'is hydrogen; another embodiment of R1 " is halogen such as chloro or fluoro; another embodiment of R1'is nitro; another embodiment of R1'is C1-6-alk(en/yn)yloxy such as methoxy. Typically, R1'is selected from the group consisting of hydrogen and C1-6-alk(en/yn)yl. To further illustrate without-limiting the invention an-embodiment of R is hydrogen; another embodiment of R1'is C1-6-alk(en/yn)yl such as methyl. In a further embodiment of the compound of formula IV, R1 is selected from the group consisting of C3-8-cycloalk(en)yl and C3.8-cycloalk(en)yl-C1-6-alk(en/yn)yl. Typically, R is selected from the group consisting of hydrogen and C1-6-alk(en/yn)yl. To further illustrate without limiting the invention an embodiment of R is hydrogen; another embodiment of R1'is C1-6-alk(en/yn)yl such as methyl. In a further embodiment of the compound of formula IV, X is selected from the group consisting of CHR1'and CR1'R1', Y is selected from the group consisting of CHR1'and CR1'R"'Z is selected from the group consisting of CHR1'and CR1°R1'and Q is selected from the group consisting of CHR1 and CR1R1"'. In a further embodiment of the compound of formula IV, X, Y, Z and Q are CH2. In a further embodiment of the compound of fonnula IV, m+ n + o + p equals to 1,2, 3 or 4; in another embodiment of formula IV, m+ n + o + p equals to 1; in another embodiment of formula IV, m+ n 4- o + p equals to 2; in another embodiment of formula IV, m+ n + o + p equals to 3; in another embodiment of formula IV, m+ n + o + p equals to 4. i as the free base or a salt thereof. Each of these compounds is considered a specific embodiment and may be subjected to individual claims. The present invention comprises the free base and salts of the compounds of the invention, typically, pharmaceutically acceptable salts. The salts of the invention include acid addition salts, metal salts, ammonium and alkylated anmionium salts. The salts of the invention are preferably acid addition salts. The acid addition salts of the invention are preferably pharmaceutically acceptable salts of the compounds of the invention formed with non-toxic acids. Acid addition salts include salts of inorganic acids as well as organic acids. Examples of suitable inorganic acids include hydrochloric, hydrobromic, hydroiodic, phosphoric, sulfuric, sulfamic, nitric acids and the like. Examples of suitable organic acids include formic, acetic, trichloroacetic, trifluoroacetic, propionic, benzoic, cinnamic, citric, fumaric, glycolic, itaconic, lactic, methanesulfonic, maleic, malic, malonic, mandelic, oxalic, picric, pyruvic, salicylic, succinic, methane sulfonic, ethanesulfonic, tartaric, ascorbic, pamoic, bismethylene salicylic, ethanedisulfonic, gluconic, citraconic, aspartic, stearic, palmitic, EDTA, glycolic, p-aminobenzoic, glutamic, benzenesulfonic, p-toluenesulfonic acids, theophylline acetic acids, as well as the 8-alotheophyllines, for example 8-bromotheophylline and the like. Further examples of pharmaceutical acceptable inorganic or organic acid addition salts include the pharmaceutically acceptable salts listed in 7. Phann, ScL 1977, 66, 2, which is incorporated herein by reference. Also intended as acid addition salts are the hydrates, which the present compounds are able to form. Examples of metal salts include lithium, sodium, potassium, magnesium salts and the like. Examples of ammonium and alkylated ammonium salts include ammonium, methyl-, dimethyl-, trimethyl-, ethyl-, hydroxyethyl-, diethyl-, n-butyl-, sec-butyl-, tert-butyl-, tetramethylamraonium salts and the like. Further, the compounds of this invention may exist in unsolvated as well as in solvated forms with pharmaceutically acceptable solvents such as water, ethanol and the like. In general, the solvated forms are considered equivalent to the unsolvated forms for the purposes of this invention. The compounds of the present invention may have one or more asymmetric centre and it is intended that any optical isomers (i.e. enantiomers or diastereomers), as separated, pure or partially purified optical isomers and any mixtures thereof including racemic mixtures, i.e. a mixture of stereoisomeres, are included within the scope of the invention, Racemic forms can be resolved into the optical antipodes by known methods, for example, by separation of diastereomeric salts thereof with an optically active acid, and liberating the optically active amine compound by treatment with a base. Another method for resolving racemates into the optical antipodes is based upon chromatography on an optically active matrix. Racemic compounds of the present invention can also be resolved into their optical antipodes, e.g. by fractional crystallization. The compounds of the present invention may also be resolved by the formation of diastereomenc derivatives. Additional methods for the resolution of optical isomers, known to those skilled in the art, may be used. Such methods include those discussed by J. Jaques, A. Collet and S. Wilen in "Enantiomers, Racemates, and Resolutions", John Wiley and Sons, New York (1981). Optically active compounds can also be prepared from optically active starting materials, or by stereoselective synthesis. Furthermore, when a double bond or a fully or partially saturated ring system is present in the molecule geometric isomers may be formed. It is intended that any geometric isomers, as separated, pure or partially purified geometric isomers or mixtures thereof are included within the scope of the invention. Likewise, molecules having a bond with restricted rotation may form geometric isomers. These are also intended to be included within the scope of the present invention. Furthermore, some-of the compounds of the present invention may exist in different-tautomeric forms and it is intended that any tautomeric forms that the compounds are able to form are included within the scope of the present invention. The invention also encompasses prodrugs of the present compounds, which on administration undergo chemical conversion by metabolic processes before becoming pharmacologically active substances. In general, such prodrugs will be functional derivatives of the compounds of the general formula IV which are readily convertible in vivo into the required compound of the formula IV. Conventional procedures for the selection and preparation of suitable prodrug derivatives are described, for example, in "Design of Prodrugs", ed. H. Bundgaard, Elsevier, 1985, The invention also encompasses active metabolites of the present compounds. Some compounds according to the invention inhibit the serotonin transporter and are thus serotonin reuptake inhibitors. Typically, the compounds have an in vitro uptake inhibition (IC50) of 5 [xM or less, typically of 1 [xM or less, preferably less than 500nM or less than 100 nM or less than 50 nM, preferably as measured by the method described in Example 13 - Measurements of "['H]-5-HT uptake into rat cortical synaptosomes". Some compounds according to the invention inhibit the norepinephrine transporter and are thus norepinephrine reuptake inhibitors. The compounds typically have an in vitro uptake inhibition (IC50) of 5 yiM or less, typically of 1 |xM or less, preferably less than 500nM, less than 100 nM or less than 50 nM, as measured by the method described in Example 13 -Measurements of "['H]noradrenaline uptake into rat cortical synaptosomes". Some compounds according to the invention inhibit the dopamine transporter and are thus dopamine reuptake inhibitors. Typically, such compounds have an in vitro uptake inhibition (IC50) of 5 |xM or less, typically of 1 (xM or less, preferably less than 500nM, less than 100 nM or less than 50 nM, preferably as measured by the method described in Example 13-"Measurements of ['H]dopamine uptake into rat cortical synaptosomes". As already mentioned, the compounds according to the invention are serotonin reuptake inhibitors and-they are thus considered to be applicable in the treatment of one or more of the following diseases/disorders: affective disorders, pain disorders, ADHD and stress urinary incontinence. An embodiment concerns compounds of the invention having dual action, said compounds being serotonin reuptake inhibitors and norepinephrine reuptake inhibitors at the same time. Typically, such compounds have an in vitro uptake inhibition for the serotonin transporter which is at least 1, typically at least 5 or even more typically at least 10, 20 or 30 times higher than the in vitro uptake inhibition for the norepinephrine transporter as measured by the methods described in Example 13 - "Measurements of ['H]-5-HT uptake into rat cortical synaptosomes" and "Measurements of ["'ITlnoradrenaline uptake into rat cortical synaptosomes". An embodiment concerns compounds of the invention having dual action, said compounds being serotonin reuptake inhibitors and dopamine reuptake inhibitors at the same time. Typically, such compounds have an in vitro uptake inhibition for the serotonin transporter which is at least 1, typically at least 5 or even more typically at least 10, 20 or 30 times higher than the in vitro uptake inhibition for the dopamine transporter as measured by the methods described in Example 13 - "Measurements of ["'Hl-S-HT uptake into rat cortical •J synaptosomes" and "Measurements of [ H]dopamine uptake into rat cortical synaptosomes". A further embodiment concerns compounds of the invention having triple action and thus being serotonin reuptake inhibitors, norepinephrine reuptake inhibitors and dopamine reuptake inhibitors. In a further aspect the invention provides a compound of formula IV as the free base or a salt thereof for use as a medicament. An embodiment of the invention provides a pharmaceutical composition comprising a compound of formula IV as the free base or a salt thereof and at least one pharmaceutically acceptable carrier or diluent The composition may comprise any one of the embodiments of formula IV described above. A further embodiment of the invention relates to the use of a compound of formula IV as the free base or a salt thereof for the preparation of a pharmaceutical composition for the treatment of a disease or disorder wherein a serotonin reuptake inhibitor is beneficial. Such pharmaceutical composition may comprise any one of the embodiments of formula IV described above. A further embodiment of the invention relates to the use of a compound of formula IV as the free base or a salt thereof for the preparation of a pharmaceutical composition for the treatment of a disease or disorder, wherein a combined serotonin and norepinephrine reuptake inhibitor is beneficial. Such pharmaceutical composition may comprise any one of the embodiments of formula IV described above. A further embodiment of the invention relates to the use of a compound of fonnula IV as the free base or a salt thereof for the preparation of a pharmaceutical composition for the treatment of a disease or disorder, wherein a combined serotonin and dopamine reuptake inhibitor is beneficial. Such pharmaceutical composition may comprise any one of the embodiments of formula IV described above. A further embodiment of the present invention relates to the use of a compound of formula IV as the free base or a salt thereof for the preparation of a pharmaceutical composition for the treatment of a disease or disorder, wherein a combined serotonin, norepinephrine and dopamine reuptake inhibitor is beneficial. Such pharmaceutical composition may comprise any one of the embodiments of formula IV described above. A further embodiment of the invention relates to the use of a compound of formula IV as the free base or a salt thereof for the preparation of a pharmaceutical composition for the treatment of affective disorders, pain disorders, ADHD and stress urineiry incontinence. In a further embodiment the present invention relates to the use of a compound of formula rv as the free base or a salt thereof for the preparation of a pharmaceutical composition for the treatment of affective disorders. To further illustrate without limiting the invention, the affective disorder to be treated is selected from the group consisting of depressive disorders and anxiety disorders; - - - A further embodiment concerns the use of a compound of formula IV as the free base or a salt thereof for the preparation of a pharmaceutical composition for the treatment of depressive disorders. Typically, the depressive disorder to be treated is selected from the group consisting of major depressive disorder, postnatal depression, dysthymia and depression associated with bipolar disorder, alzheimers, psychosis or parkinsons. A further embodiment concerns the use of a compound of formula IV as the free base or a salt thereof for the preparation of a pharmaceutical composition for the treatment of anxiety disorders. Typically, the anxiety disorders to be treated are selected from the group consisting of general anxiety disorder, social anxiety disorder, post traumatic stress disorder, obsessive compulsive disorder, panic disorder, panic attacks, specific phobias, social phobia and agoraphobia. In a further embodiment the present invention relates to the use of a compound of formula rv as the free base or a salt thereof for the preparation of a pharmaceutical composition for the treatment of pain disorders. To further illustrate without limiting the invention, the pain disorder to be treated is selected from the group consisting of fibromyalgia syndrome (FMS)» overall pain, back pain, shoulder pain, headache as well as pain while awake and during daily activities. In a further embodiment the present invention relates to the use of a compound of formula IV as the free base or a salt thereof for the preparation of a pharmaceutical composition for the treatment of attention deficit hyperactivity disorder. In a further embodiment the present invention relates to the use of a compound of formula rv as the free base or a salt thereof for the preparation of a pharmaceutical composition for the treatment of stress urinary incontinence. In a further aspect, the present invention relates to a method of preparing a compound of formula IV, comprising the nucleophilic substitution reaction of appropriately substituted indoles and appropriately substituted benzene sulfenyl chlorides. The term "treatment" as used herein in connection with a disease or disorders includes also prevention as the case may be. PHARMACEUTICAL COMPOSITIONS The present invention also relates to a pharmaceutical composition. The compounds of the invention may be administered alone or in combination with pharmaceutically acceptable carriers or diluents, in either single or multiple doses. The pharmaceutical compositions according to the invention may be formulated with pharmaceutically acceptable carriers or diluents as well as any other known adjuvants and excipients in accordance with conventional techniques such as those disclosed in Remington: The Science and Practice of Pharmacy, 19 Edition, Gennaro, Ed., Mack Publishing Co., Easton, PA, 1995. The pharmaceutical compositions may be specifically formulated for administration by any suitable route such as the oral, rectal, nasal, pulmonary, topical (including buccal and sublingual), transdermal, intracistemal, intraperitoneal, vaginal and parenteral (including subcutaneous, intramuscular, intrathecal, intravenous and intradermal) route, the oral route being preferred. It will be appreciated that the preferred route will depend on the general condition and age of the subject to be treated, the nature of the condition to be treated and the active ingredient chosen. The pharmaceutical compositions formed by combining the compound of the invention and the pharmaceutical acceptable carriers are then readily administered in a variety of dosage forms suitable for the disclosed routes of administration. The formulations may conveniently be presented in unit dosage form by methods known in the art of pharmacy. The compounds of this invention are generally utilized as the free substance or as a pharmaceutically acceptable salt thereof. One example is an acid addition salt of a compound having the utility of a free base. When a compound of the invention contains a free base such salts are prepared in a conventional manner by treating a solution or suspension of a free base of the invention with a chemical equivalent of a pharmaceutically acceptable acid. Representative examples are mentioned above. Pharmaceutical compositions for oral administration may be solid or liquid. Solid dosage forms for oral administration include e.g. capsules, tablets, dragees, pills, lozenges, powders, granules and tablette e.g. placed in a hard gelatine capsule in powder or pellet form or e.g. in the form of a troche or lozenge. Where appropriate, pharmaceutical compositions for oral administration may be prepared with coatings such as enteric coatings or they can be formulated so as to provide controlled release of the active ingredient such as sustained or prolonged release according to methods well known in the art. Liquid dosage forms for oral administration include e.g. solutions, emulsions, suspensions, syrups and elixirs. Formulations of the present invention suitable for oral administration may be presented as discrete units such as capsules or tablets, each containing a predetermined amount of the active ingredient, and which may include a suitable excipient Furthermore, the orally available formulations may be in the form of a powder or granules, a solution or suspension in an aqueous or non-aqueous liquid, or an oil-in-water or water-in-oil liquid emulsion. Suitable pharmaceutical carriers include inert solid diluents or fillers, sterile aqueous solution and various organic solvents. Examples of solid carriers are lactose, terra alba, sucrose, cyclodextrin, talc, gelatine, agar, pectin, acacia, magnesium stearate, stearic acid, lower alkyl ethers of cellulose, com starch, potato starch, gums and the like. Examples of liquid carriers are syrup, peanut oil, olive oil, phospho lipids, fatty acids, fatty acid amines, polyoxyethylene and water. The carrier or diluent may include any sustained release material known in the art, such as glyceryl monostearate or glyceryl distearate, alone or mixed with a wax. Any adjuvants or additives usually used for such purposes such as colourings, flavourings, preservatives etc. may be used provided that they are compatible with the active ingredients. The amount of solid carrier may vary but will usually be from about 25 mg to about 1 g. If a liquid carrier is used, the preparation may be in the form of a syrup, emulsion, soft gelatine capsule or sterile injectable liquid such as an aqueous or non-aqueous liquid suspension or solution. Tablets may be prepared by mixing the active ingredient with ordinary adjuvants and/or diluents and subsequently compressing the mixture in a conventional tabletting machine. Pharmaceutical compositions for parenteral administration include sterile aqueous and nonaqueous injectable solutions, dispersions, suspensions or emulsions as well as sterile powders to be reconstituted in sterile injectable solutions or dispersions prior to use. Depot injectable formulations are also contemplated as being within the scope of the present invention. For parenteral administration, solutions of the compound of the invention in sterile aqueous solution, aqueous propylene glycol, aqueous vitamin E or sesame or peanut oil may be employed. Such aqueous solutions should be suitably buffered if necessary and the liquid diluent first rendered isotonic with sufficient saline or glucose. The aqueous solutions are particularly suitable for intravenous, intramuscular, subcutaneous and intraperitoneal administration. The sterile aqueous media employed are all readily available by standard techniques known to those skilled in the art. Solutions for injections may be prepared by dissolving the active ingredient and possible additives in a part of the solvent for injection, preferably sterile water, adjusting the solution to the desired volume, sterilising the solution and filling it in suitable ampoules or vials. Any suitable additive conventionally used in the art may be added, such as tonicity agents, preservatives, antioxidants, etc. Other suitable administration forms include suppositories, sprays, ointments, cremes, gels, inhalants, dermal patches, implants, etc. A typical oral dosage is in the range of from about 0.001 to about 100 mg/kg body weight per day, preferably from about 0.01 to about 50 mg/kg body weight per day, and more preferred from about 0.05 to about 10 mg/kg body weight per day administered in one or more dosages such as I, 2 or 3 dosages. The exact dosage will depend upon the frequency and mode of administration, the sex, age, weight and general condition of the subject treated, the nature and-severity of the condition treated and any concomitant diseases to be treated and other factors evident to those skilled in the art. The formulations may convenientiy be presented in unit dosage form by methods known to those skilled in the art A typical unit dosage form for oral administration one or more times per day such as 1, 2 or 3 times per day may contain from 0.01 to about 1000 mg, such as about 0.01 to 100 mg, preferably from about 0.05 to about 500 mg, and more preferred from about 0.5 mg to about 200 mg. For parenteral routes such as intravenous, intrathecal, intramuscular and similar administration, typically doses are in the order of about half the dose employed for oral administration. Typical examples of recipes for the formulation of the invention are as follows: By the expression a compound of the invention is meant any one of the embodiments of formula IV as described herein. In a further aspect the present invention relates to a method of preparing a compound of the invention as described in the following. METHODS OF PREPARATION OF THE COMPOUNDS OF THE INVENTION General Methods Compounds of formula IV may be prepared by conventional synthetic techniques as described in the methods below. Method 1. For the preparation of compounds of formula IV (for R1 R1 't H). The appropriate indole of formula V is combined with the appropriate sulfenyl chloride of formula VI (for R\ R1 'H) to generate the desired product of formula IV, using known methodology (Hamel P. et al /. Heterocyclic Chem,, 1999, 36, 643). The product of formula IV is isolated as the free base or a salt thereof. Indoles of formula V are either commercially available or can be prepared according to methods described in standard works such as Houben-Weyl, Methoden der organischen Chemie (Methods of Organic Chemistry), Georg-Thieme-Verlag, Stuttgart; Organic Reactions, John Wiley & Sons, Inc. New York, namely under reaction conditions such as those which are known as suitable for such reactions. Method 2. For the preparation of compounds of formula IV with R1 = H. Compounds of formula VII are deprotected by standard techniques detailed in the textbook Protective Groups in Organic Synthesis Greene and Wuts, Wiley Interscience, (1999), ISBN 0471160199. The product of formula IV is isolated as the free base or a salt thereof. where R1-R1'X, Y, Z, Q, m, n, o, p are as defined herein and PG is a nitrogen protecting group. Method 3. For the preparation of compounds of formula IV (for R1 R1 'H). Compounds of formula Vin are treated with a reducing agent such as e.g. LiAlKU or AIH3. TTie product of formula rv is isolated as the free base or a salt thereof. Methods of preparation of intermediates for the synthesis of compounds of the invention Intermediates for the synthesis of compounds of the invention may be prepared by conventional synthetic techniques as described in the methods below. Method 4. For the preparation of compounds of formula VII: The appropriate indole of formula V is combined with the appropriate sulfenyl chloride of formula IX using known methodology (Hamel P. et al J. Heterocyclic Chern., 1999, 36, 643). where R1-R1', X, Y, Z, Q, m, n, o, p are as defined herein and PG is a nitrogen protecting group. Method 5. For the preparation of compounds of formula VI (for R\ R1 'H) and for the preparation of compounds of formula DC: Reaction of a thiophenol of formula X (for R\ R1 9'= H) or of a thiophenol of formula XI with a chlorinating reagent such as AT-chloro succinimide. I For the preparation of compounds of formula X (for R\ R1 =?t H) and of compounds of formula XI; Deprotection of the thiol moiety of a protected thiol of formula XII (for R\ R1 ?i H) or of a protected thiol of formula Xm, by e.g, using a fluoride donor such as e.g. triethylamine tris(hydrogen fluoride). where R1-R1', X, Y, Z, Q, m, n, o, p are as defined herein, PG is a nitrogen protecting group and SPG is a thiol protecting group, e.g. a tri-wo-propyl silyl group. Method?. For the preparation of compounds of formula XII (for R , R 'H) and compounds of formula XHI: Reaction of a compound of formula XIV (for R\ R1 'H) or of a compound of formula XV with a protected thiol of formula XVI in the presence of a palladium catalyst and an appropriate base, according to Arnould, J. C. et al Tetrahedron Letters, 1996, 37, 4523 and Winn M. et al J, Med Chem,, 2001,44,4393. where R'-R"', X, Y, Z, Q, m, n, o, p are as defined herein, PG is a nitrogen protecting group, SPG is a thiol protecting group, e.g, a tri-fw-propyl silyl group and R1'is a halogen such as iodine or bromine or R is a pseudo halogen such as e.g. a trifluoro methyl sulphonyl group or a nonafluoro butyl sulphonyl group. Method 8. For the preparation of compounds of formula XIV (for R1 R1 ;i H; Q = CH2) and for the preparation of compounds of formula XV (for Q = CH2): Reduction of an amide of formula XVn (for R\ R1 'H) or reduction of an amide of formula XVni followed by protection of the nitrogen moiety with a nitrogen protecting group. where R'-R1 X, Y, Z, m, n, o are as defined herein and R1'is a halogen such as iodine or bromine or R1'is a pseudo halogen such as e.g. a trifluoro methyl sulphonyl group or a nonafluoro butyl sulphonyl group. Method 9. For the preparation of compounds of formula XVn and for the preparation of compounds of formula XVni; Activation of a carboxylic acid of formula XIX with an activating reagent such as e.g. thionyl chloride/iVJV-dicyclohexylcarbodiimide or carbonyl diimidazole -followed by reaction with an amine of formula XX. where R'-R°, X, Y, Z, m, n, o are as defined herein and R is a halogen such as iodine or bromine or R1'is a pseudo halogen such as e.g. a trifluoro methyl sulphonyl group or a nonafluoro butyl sulphonyl group. Amines of formula XX are commercially available or can be prepared according to methods described in standard works such as Houben-Weyl, Methoden der organischen Chemie (Methods of Organic Chemistry), Georg-Thieme-Verlag, Stuttgart; Organic Reactions, John Wiley & Sons, Inc. New York, namely under reaction conditions such as those which are known as suitable for such reactions. Method 10. For the preparation of compounds of formula XIV (for R\ R1 't H; Q = CH2 or CHR1) and for the preparation of compounds of formula XV (for Q = CH2 or CHR1'): Reductive amination of an aldehyde of formula XXI or of a ketone of formula XXn with an amine of formula XX, using a reducing reagent such as e,g, sodium cyanoborohydride. For R1 = H, the reductive amination is followed by protection of nitrogen moiety with a nitrogen protecting group. where R1-R1, R1'X, Y, Z, m, n, o are as defined herein and R1'is a halogen such as iodine or bromine or R is a pseudo halogen such as e,g. a trifluoro methyl sulphonyl group or a nonafluoro butyl sulphonyl group. Method IL For the preparation of compounds of formula XXI (for n = 1, X = CH2, Y = CH2, CHR"') and for the preparation of compounds of formulEi XXn (for n = 1, X = CH2, Y = CH2, CHR1'): A tandem Heck- isomerization reaction of a l-bromo-2-iodobenzene compound of formula XXin and an olefin of formula XXIV or of formula XXV according to Gibson et al Synlett 1999, 954 and Qadir et al Tetrahedron Letters, 44, 2003, 3675. where R'-R°, R", Y, Z, 0 are as defined herein. l-Bromo-2-iodobenzene compounds of formula XXin, olefins of formula XXIV or of formula XXV are commercially available or can be prepared according to methods described in standard works such as Houben-Weyl, Methoden der organischen Chemie (Methods of Organic Chemistry), Georg-Thieme- Verlag, Stuttgart; Organic Reactions, John Wiley & Sons, Inc. New York, namely under reaction conditions such as those which are known as suitable for such reactions. Method 12. For the preparation of compounds of formula Vni: Activation of a carboxylic acid of formula XXVI with an activating reagent such as e.g. carbonyl diimidazole followed by reaction with an amine of formula XX, Method 13. For the preparation of compounds of formula XXVI:.Hydrolysis of a carboxylic acid ester of formula XXVn. Method 14. For the preparation of compounds of formula XXVII: The appropriate indole of formula V is combined with the appropriate sulfenyl chloride of formula XXVIII to generate desired product of formula XXVn, usmg known methodology (Hamel P. et al /. Heterocyclic Chem., 1999, 36, 643). Method 15. For the preparation of compounds of formula XXVni: Reaction of a thiophenol of formula XXIX with a chlorinating reagent such as AT-chloro succinimide. where R-'-R", X, Y, Z, m, n, o are as defined herein. Method 16. For the preparation of compounds of formula XXIX: Deprotection of the thiol moiety of a protected thiol of formula XXX, where R1R1 X, Y, Z, m, n, o are as defined herein and SPG is a thiol protecting group, e.g. a In-iso-'XG'yX silyl group or a methoxycarbonyl ethyl group. Method 17. For the preparation of compounds of formula XXX: Reaction of a compound of formula XXXI with a protected thiol of formula XVI in the presence of a palladium catalyst and an appropriate base according to Amould, J, C. et al Tetrahedron Letters, 1996,37,4523 and Winn M. et al J. Med. Chem., 2001,44,4393. n where R'-R1, X, Y, Z, m, n, o are as defined herein, SPG is a thiol protecting group, e.g. a tri-/w-propyl silyl group or a methoxycarbonyl ethyl group, and R1'is a halogen such as iodine or bromine or R is a pseudo halogen such as e.g. a trifluoro methyl sulphonyl group or a nonafluoro butyl sulphonyl group. Method 18. For the preparation of compounds of fonnula XXXI: Fischer esterification of a carboxylic acid of formula XXXH: •J £ rye where R'-R°, X. Y, Z, m, n, o are as defined herein, and R is a halogen such as iodine or bromine. Carboxylic acids of formula XXXII are commercially available or can be prepared according to methods described in standard works such as Houben-Weyl, Methoden der organischen Chemie (Methods of Organic Chemistry), Georg-Thieme-Verlag, Stuttgart; Organic Reactions, John Wiley & Sons, Inc. New York, namely under reaction conditions such as those which are known as suitable for such reactions. EXAMPLES Analytical LC-MS data (Method A) were obtained on a PE Sciex API 150EX instrument equipped with atmospheric pressure photo ionisation and a Shimadzu LC-8A/SLC-10A LC system. Column: 30 X 4.6 mm Waters Symmetry CI8 column with 3.5 (xm particle size; Solventsystem: A = water/trifluoroacetic acid (100:0.05) and B = water/acetonitrile/trifluoroacetic acid (5:95:0.03); Method: Linear gradient elution with 90% A/10% B to 100% B in 4 minutes and with a flow rate of 2 mL/minute. Purity was determined by integration of the UV (254 nm) and ELSD trace. The retention times (IR) are expressed in minutes. Preparative LC-MS-purification was performed on the same instrument with atmospheric pressure chemical ionisation. Column: 50 X 20 mm YMC ODS-A with 5 \xm particle size; Method: Linear gradient elution with 80% A to 100% B in 7 minutes and with a flow rate of 22.7 mL/minute. Fraction collection was performed by split-flow MS detection. Analytical LC-MS-TOF (TOF = time of flight) data (Metiiod B) were obtained on a micromass LCT 4-ways MUX equipped with a Waters 2488/Sedex 754 detector system. Column:-30 X 4.6 mm Waters Symmetry GI8 colunrn with 3.5 ixm particle size; Solventsystem: A = water/trifluoroacetic acid (100:0.05) and B = water/acetonitrile/trifluoroacetic acid (5:95:0.03); Method: Linear gradient elution with 90% A/10% B to 100% B in 4 minutes and with a flow rate of 2 mL/minute. Purity was deterniined by integration of the UV (254 nm) and ELSD trace. The retention times (tR) are expressed in minutes. The invention disclosed herein is further illustrated by the following non-limiting examples. Preparation of the compounds of the invention Example 1 Synthesis of L {2'l5'fluoro'2'(lH4ndoU3'ykulfanyl)'phenyl]-ethyl}-met'(Method 2) {2"[5-Fluoro-2-(lH-indol-3-ylsulfanyl)-phenyl]-ethyl}-methyl-carbamic acid tert-butyl ester (99 mg, 0.24 mmol) is dissolved in methanol (1.5 mL) and diethyl ether saturated with hydrochloric acid (0.5 mL) is added. The mixture is stirred at ambient temperature for 2 hours and concentrated in vacuo. Water (5 mL) is added to the remanence and the mixture is basified by addition of aqueous ammonia (25%). The aqueous fraction is extracted with ethyl acetate (3 x lOntiL). The combined organic fractions are dried (MgS04) and concentrated in vacuo. The product is purified by preparative HPLC or silica g&l chromatography eluting with ethyl acetate-ethanol-triethyl amine (100:5:5) to give 62 mg (83%) of the title compound. The following compounds were prepared analogously: 2. {2-[2-(6-Fluoro- lH-indol-3-ylsulfanyl)-phenyl]"ethyl }-methyl-amine 3. {2-[2-(5-Fluoro-lH-indol-3-ylsulfanyl)-phenyl]-ethyl}-methyl-amine The following compound was prepared analogously: 33.MethyI-{3-[2K5-methyl--lH-indol-3-ylsulfanyl)-phenyl]-propyl}"aniine Analytical data of compounds 1-24 are shown in Table 2. Example 2 Synthesis of 55" {2'[2'(lH4ndol'3'ylsulfanyl)'phenylJ'ethyl}'dimethyl'amine (Method 3.) 2-[2-(lH-Indol-3-ylsulfanyl)-phenyl]-iV,N-dimethyl-acetamide (116 mg, 0.37 mmol) in 6 mL THF is added to LiAHU (43 mg, 1.12 mmol) in 4 mL THF. The reaction mixture is stirred 16 hours at 50°C. The reaction is quenched with water and 2N NaOH. The reaction mixture is stirred for 1 hour, then 2.5 mL water is added and stirring was continued for another hour. The mixture is filtered, dried with MgS04 and concentrated in vacuo. Purification by flash chromatography or preparative HPLC to gives the title compound. The following compounds were prepared analogously: 36.3-[2-(2-Morpholin-4"yl-ethyl)-phenylsulfanyl]-lH-indole Preparation of intermediates Example 3 Synthesis of {2-[5-FluorO'2'(lH4ndoU3-ykulfanyl)'phenyl]'ethyl}'methy acid terUbutyl ester (Method 4, Method 5, Method 14., Method 15.) [2-(5-Fluoro-2-inercapto-phenyi)-ethyl3"methyl-carbamic acid tert-butyl ester (240 mg, 0.84 mmol) is dissolved in dry THE (3 mL) and added dropwise to a solution of N-chlorosuccinimide (112 mg, 0.84 mmol) in 1,2-dichloroethane (3 mL) at 0°C. The mixture is allowed to heat to ambient temperature and is stirred for 30 minutes. The resulting sulfenyl chloride solution is added dropwise to a solution of IH-indole (147 mg, 1.26 mmol) in dry THF (3 mL) at 0°C. The mixture is stirred for 15 minutes at 0°C before adding saturated sodium bicarbonate solution (15 mL). The mixture is extracted with ethyl acetate (3 x 20 mL) and the combined organic fractions are washed with brine, dried (MgS04) and concentrated in vacuo. The product is purified by silica gel chromatography eluting with ethyl acetate-heptane, first (1:10) then (1:4). Upon evaporation of the volatiles 99 mg (29%) of the title compound is isolated. The following intermediates were prepared analogously: {2-[5-Fluoro-2-( 1 H-indol-3-ylsulfanyl)"phenyl]-ethyl}-methyl-carbamic acid tert-butyl ester {2-[2-(6-Fluoro-lH-indol-3-ylsulfanyl)-phenyl]-ethyl}-methyl-carbamic acid tert-butyl ester {2-[2-(5-Fluoro-lH-indol-3-ylsulfanyl)-phenyl]-ethyI}-methyI-carbamic acid tert-biityl ester {2-[2-(4-Fluoro-lH-indol-3-ylsulfanyl)-phenyl]-ethyl}-methyl-carbamic acid tert-butyl ester {2-[2-(7-Fluoro-lH"indol"3-ylsulfanyl)-phenyl]-ethyl}-methyl-carbamic acid tert-butyl ester {2-[2-(7-Methoxy-1 H-indol-3"ylsulfanyl)-phenyl]-ethyl }-methyl-carbamic acid tert-butyl ester {2-[2-(5-Fluoro-2-methyl-lH-indol-3-ylsulfanyl)-phenyl]-ethyl}-methyl-carbamic acid tert-butyl ester {2-[2-(5-Chloro-lH-indol-3-ylsulfanyl)-phenyl]-ethyl}-methyl-carbamic acid tert-butyl ester {2-[2-(4-Chloro-lH-indol-3-ylsulfanyl)-phenyl]-ethyl}-methyl-carbamic acid tert-butyl ester {2-[2-(7-Chloro-1 H-indol-3-ylsulfanyl)-phenyl]-ethyl }-methyl-carbamic acid tert-butyl ester {2-[2-(lH-Indol-3-ylsulfanyl)-phenyl]-ethyl}-methyl-carbamic acid tert-butyl ester {2-[2-(l-Methyl-indol-3-ylsulfanyl)-phenyl]-ethyi)-methyl-carbamic acid tert-butyl ester {2-[5-Chloro-2-(lH-indoI-3"ylsulfanyl)-phenyl]-ethyl}-methyl-carbamic acid tert-butyl ester {2-[5-Chloro-2-(6-fluoro-lH-indoir3-ylsulfanyl)"phenyl]-ethyl }-methyl-carbamic acid tert-butyl ester {2-[5-Chloro-2-(4-chloro-lH-indol-3-ylsulfanyl)-phenyl]-ethyl }-methyl-carbamic acid tert-butyl ester (2-[5-Fluoro-2-(6-fluoro-lH-indol-3-ylsulfanyl)-phenyl]-ethyI}-methyl-carbamic acid tert-butyl ester (2-(2-(4-Chloro-lH-indol-3-ylsulfanyl)-5-fluoro-phenyl)-ethyi)-methyl-carbamic acid tert- butyl ester {2-[2-(6-Fluoro-lH-indol-3-ylsulfanyl)-4,5-dimethoxy-phenyl]--ethyl}-metiiyl--carbamic acid tert-butyl ester {2-[2-(4-Chloro-lH-indol-3-ylsulfanyl)-4,5-dimethoxy-phenyl]-ethyl}-methyl-carbamic acid tert-butyl ester {2-[2-( lH-Indol-3-ylsulfanyl)-4,5-diinethoxy-phenyl]-ethyl }-methyl-carbamic acid tert- butyl ester - ■ {4-[2-(lH-Indol-3-ylsulfanyl)-phenyl]-butyl}-inethyl-carbainic acid tert-butyl ester 4-[2-(4-Methoxy-lH-indol-3-ylsulfanyl)-phenyl]-butylcarbamic acid tert-butyl ester {4-[2-(4-Chloro-lH-indol-3-ylsulfanyl)-phenyl]-butyl}-methyl-carbamic acid tert-butyl ester Methyl-{4-[2-( 1 -methyHH-indol-3-ylsulfanyl)-phenyl]-butyl}-carbamic acid tert-butyl ester [2-(lH-Indol-3"ylsulfanyl)-phenyl]-acetic acid methyl ester The following intermediates are prepared analogously: {3-[2-(4-Chloro-lH-indol-3-ylsulfanyl)-phenyl]-propyl}-methyl-carbamic acid tert-butyl ester {3-[2-(4-Methoxy-lH-indol-3-ylsulfanyl)-phenyl]-propyl}-methyl-carbamic acid tert-butyl ester {3-[2-(5-Dimethylamino-lH-indol-3-ylsulfanyl)-phenyl]-propyl}-methyl-carbamic acid tert-butyl ester Methyl-{3-[2-(7-nitro-lH-indol-3-ylsulfanyl)"phenyl]-propyI}-carbamic acid tert-butyl ester {3-[2-(6-Methanesulfonyl-lH-indol-3-ylsulfanyl)-phenyl]-propyl}-methyl-carbamic acid tert-butyl ester {3-[2-(lH-Indol-3-ylsulfanyl)-phenyl]-propyl}-methyl-carbamic acid tert-butyl ester {3-[2-(6-Fluoro-lH-indol-3-ylsulfanyl)-phenyl]-propyl}-methyl-carbainic acid tert-butyl ester Methyl- {3-[2-( 1 -methyl-lH-indol-3-ylsulfanyl)-phenyl]-propyl}-carbamic acid tert-butyl ester Methyl-{3-[2-(5-methyHH-indol-3-ylsulfanyl)-phenyl]-propyl}-carbamic acid tert-butyl ester Example 4 Synthesis ot[2'(5-fluorO'2'mercaptO'phenyl)'ethyl]'methyUcarbamic acid tert-butyl ester (Method 6, Method 16.) [2-(5-Fluoro-2-triisopropylsilanylsulfanyl-phenyl)-ethyl]-methyl-carbamic acid tert-butyl ester (L60 g, 3,62 mmol) is dissolved in dry THF (12 mL) and triethylamine trihydrofluoride (0.59 g, 3.66 mmol) is added. The resulting mixture is heated at 60°C for 5 minutes, then cooled and concentrated in vacuo. The product is purified by eluting through a plug of silica with ethyl acetate-heptane (1:4) to give 0.72 g (72%) of the title compound as an oil. The following intermediates were prepared analogously: [2-(2-Mercapto-phenyl)-ethyl]-methyl-carbamic acid tert-butyl ester [2-(5-Chloro-2-mercapto-phenyl)-ethyl]-methyl-carbamic acid tert-butyl ester [2-(2-Mercapto-4,5-dimethoxy-phenyl)-ethyl]-methyl-carbamic acid tert-butyl ester [4-(2-Mercapto-phenyl)-butyl]-methyl-carbamic acid tert-butyl ester (2-Mercapto-phenyl)-acetic acid methyl ester [3-(2-Mercapto-phenyl)-propyl]-methyl-carbamic acid tert-butyl ester Example 5 Synthesis of [2'(S'fluorO'2'triisopropylsilanylsulfanyl'phenyl)'eth' acid tert-butyl ester (Method 7, Method 17.) [2-(2-Bromo-5-fluoro-phenyI)-ethyl]-methyl-carbamic acid tert-butyl ester (3.0 g, 9,03 mmol), tris(dibenzylideneacetone)dlpalladium (0) (83 mg, 0.09 mmol), bis(2-diphenylphosphinophenyl)ether (97 mg, 0.18 mmol), sodium tert-butoxide (1.10 g, 11.7 mmol), triisopropylsilanethiol (1.90g, 9.93 mmol) and dry toluene (15 mL) are all placed in an Emrys Optimizer EXP 20 mL microwave reactor tube. The reaction vessel is sealed and subjected to microwave heating at 160°C for 15 minutes. Upon cooling the mixture is poured onto a plug of silica and the product is eluted with ethyl acetate-heptane (1:10). This furnishes 1.6 g (40%) of the title compound as an oil, which is used in the next step without further purification. The following intermediates were prepared analogously: Methyl-[2-(2-triisopropylsilanylsulfanyl-phenyl)"ethyl]-carbamic acid tert-butyl ester [2-(5-Chloro-2"triisopropylsilanylsulfanyl-phenyl)-ethyl]-methyl-carbamic acid tert-butyl ester [2-(4,5-Dimethoxy-2-triisopropylsilanylsulfanyl-phenyl)-ethyl]-methyl-carbamic acid tert-butyl ester Methyl-[4-(2-triisopropylsilanylsulfanyl-phenyl)-butyl]-carbamic acid tert-butyl ester . (2-TriisopropyIsilanylsulfanyl-phenyl)-acetic acid methyl ester Methyl-[3-(2-triisopropylsilanylsulfanyl-phenyl)-propyl]-carbamic acid tert-butyl ester Example 6 Synthesis ot[2'(2'bromO'5'fluorO'phenyl)-ethyl]'methyl-amine (Method 8) Lithium aluminum hydride (7.50 g, 197 mmol) is suspended in dry diethyl ether (75 mL) and cooled to 0°C. Aluminum (HI) chloride (8.80g, 65.8 mmol) dissolved in dry diethyl ether (75 mL) is added dropwise at 0-5 °C. The cooling bath is removed and the mixture is stirred at ambient temperature for 1 hour. The resulting aluminum hydride reagent solution is cooled to 0°C followed by dropwise addition of 2-(2-bromo-5-fluoro-phenyl)-N-methyl-acetamide (16.2 g, 65.8 mmol) dissolved in dry THF (150 mL). After complete addition the solution is allowed to heat to ambient temperature and stirring is continued for 16 hours. The mixture is cooled to 10°C followed by slow dropwise addition of water (16 mL) followed by 2M sodium hydroxide (16 mL) and water (80 mL) to quench excessive reducing agent. The mixture is filtered and concentrated in vacuo. The remanence is redissolved in ethyl acetate (200 mL), dried (MgSO4) and concentrated again to give 14,6 g (95%) of the title compound as an oil. The following intermediates were prepared analogously: [2-(2-Iodo-phenyl)-ethyl]-methyl"amine [2-(2-Bromo-5-chloro-phenyl)-ethyl]-methyl-amine [2-(2-Bromo-4,5-dimethoxy-phenyl)-ethyl]-methyl-amine [4-(2-Bromo-phenyl)-butyl]-methyl-araine Synthesis of [2'(2'bromO'5'fluoro'phenyiyethyl]-methyUcarhainic acid tert-butyl ester (Method 8) [2-(2-Bromo-5-fluoro-phenyl)"ethyl]-methyl-amine (14.6 g, 62.9 mmol) is dissolved in dry THF (200 mL) and di-tert-butyl dicarbonate (15.1 g, 69.2 mmol) is added. The mixture is stirred for 16 hours at ambient temperature. The volatiles are removed by means of evaporation and the crude mixture is purified by silica gel chromatography eluting with ethyl acetate-heptane (1:4) to furnish 19.4 g (93%) of the title compound as an oil. The following intermediates were prepared analogously: [2-(2-Iodo-phenyl)-ethyl]-methyl-carbamic acid tert-butyl ester [2-(2-Bromo-5-chloro-phenyl)-ethyl]-methyl-carbamic acid tert-butyl ester [2-(2-Bromo-4,5-dimetiioxy-phenyl)-ethyl]-methyl-carbamic acid tert-butyl ester [4-(2-Bromo-phenyl)-butyl]-methyl-carbamic acid tert-butyl ester Example 7 Synthesis of 2-(2-bromO'5'fluorO'phenyl)'N-methyl'acetainide (Method 9) Thionyl chloride (9.4 mL, 129 mmol) is added to a solution of (2-bromo-5-fluoro-phenyI)-acetic acid (20.0 g, 85.8 mmol) in dry toluene (400mL). The mixture is heated at reflux for 4 hours and the solvent is removed in vacuo. The remanence is redissolved in dry toluene (400 mL) and cooled to 0°C. 40% methylamine (aq.) (17.7 mL, 515 mmol) is added dropwise at 0-5°C. The mixture is then stirred at ambient temperature for 16 hours, poured onto water (250 mL) and extracted with ethyl acetate (3 x 200 mL). The combined organic fractions are washed successively with saturated sodium bicarbonate solution (150 mL) and brine (150 mL), dried (MgS04) and concentrated in vacuo. This gives 16.2 g (77%) of crystalline 2-(2-bromo-5-fluoro-phenyl)-N-methyl-acetamide. The following intermediates were prepared analogously: 2-(2-Iodo-phenyl)-N-methyl-acetamide 2-(2-Bromo-5-chloro-phenyl)-N-methyl-acetamide 2-(2-Bromo-4,5-dimethoxy-phenyl)-N-methyl-acetamide 4-(2-Bromo-phenyl)-N-methyl-butyramide Example 8 Synthesis otlS-il-bromo-phenyiypropylJ-methyUcarbamic acid tert-butyl ester (Method 10.) Methyl amine (8M in ethanol, 38 mL, 304 mmol) is added to 3-(2-bromO"phenyl)- propionaldehyde (6,32 g, 29.7 mmol) and sodium cyanoborohydride (2.24 g, 35.6 mmol) in methanol. The reaction mixture is cooled to 0°C and acetic acid is added slowly until pH The reaction mixture is stirred for V2 hour and neutralized with aqueous sodium hydroxide. Methanol is removed in vacuo and ethyl acetate and brine are added. The aqueous phase is extracted with ethyl acetate and the combined organic phases are dried with MgS04 and concentrated in vacuo. The residue is dissolved in THF (150 mL) and di-tert-hwtyl dicarbonate (7.2 g, 33 mmol) and triethyl amine (5.2 mL, 37.1 mmol) are added. The reaction mixture is stirred for 2 hours, filtered through silica gel and concentrated in vacuo. The residue is purified by flash chromatography (silica gel, ethyl acetate/heptane) to give 3.23 g (33%) of the title compound. Example 9 Synthesis of 2-[2'(lH4ndoU3'ylsulfanyl)-phenyl]'N,N'dimethyl'acetamide (Method 12.) A/',A?'-Dicyclohexylcarbodiimide (875 mg, 4.2 mmol) is added to [2-(lH"Indol-3-ylsulfanyl)--phenylj-acetic acid (600 mg, 2,1 mmol) in 3 mL dry DMF and 7 mL acetonitril and stirred for 10 minutes hours at room temperature, 5.3 mL dimethyl amine (2M in THF, 10.6 mmol) is added and the reaction mixture is stirred 16 hours at room temperature. The reaction mixture is concentrated in vacuo. The residue is extracted with ethyl acetate (3 times). The combined orgnic phases are washed with brine, dried with MgS04 and concentrated in vacuo. Purification by flash chromatography on siUca gel (ethyl acetate/heptane) gives 116 mg (18%) of the title compound. The following intermediates were prepared analogously: 2-[2-( 1 H-Indol-3-ylsulfanyl)-phenyl]-acetamide 2-[2-(lH-Indol-3-ylsulfanyl)-phenyl]-l-morpholin-4-yI-ethanone 2-[2-( 1 H-Indol-3-ylsulfanyl)-phenyl]- l-thiomorpholin-4-yl-ethanone Example 10 Synthesis ot [l-'ilH-Uidol-S-ykulfanyiyphenylJ-'acetic acid (Method 13.) LiOH (1.6 g, 67.3 mmol) is added to [2"(lH-indol-3-ylsulfanyl)-phenyl]-acetic acid methyl ester (2 g, 6.73 mmol) in 27 mL mixture of THF/water (20:7). The reaction mixture is stirred for 10 minutes at 150°C in a Emrys Optimizer EXP microwave reactor under microwave heating and cooled to room temperature. The reaction mixture is poured into water and acidified with concentrated HCl. Ethyl acetate is added and the organic phase is washed with brine, dried with MgS04 and concentrated in vacuo to give the title compound, which is used in the next step without further purification. Example 11 Synthesis of (2'bromo'phenyl)'acetic acid methyl ester (Method 18.) 2 raL H2SO4 is added to (2-bromo-phenyl)-acetic acid (15 g, 70 mmol) in 150 mL methanol. The reaction mixture is refluxed 16 hours and cooled to room temperature. 100 mL saturated NaHCOa (aq) is added. Methanol is removed in vacuo. The resulting mixture is extracted with Ethyl acetate. The organic phase is washed with brine, dried with MgS04 and concentrated in vacuo to give the title compound. Example 12 Synthesis ot 4'(2-bromO'phenyl)-butync acid Methanesulfonyl chloride (7.7 mL, 97 mmol) in 100 mL dry THF is added to a solution of 3-(2-bromo-phenyl)-propan-l-ol (17.4 g, 80.9 mmol) and triethyl amine (14.7 g, 146 mmol) in 200 mL dry THF at 0°C under an argon atmosphere. Water is added and the mixture is extracted with ethyl acetate. The organic phase is washed with brine, dried with MgS04 and concentrated in vacuo to give 23 g (97%) methanesulfonic acid 3-(2-bromo-phenyl)-propyl ester as an oil. Methanesulfonic acid 3-(2-bromo-phenyl)-propyl ester (23g, 78 nrniol) in 300 mL dry DMF is added to a suspension of potassium cyanide (15.3 g, 235 mmol) in dry DMF. The reaction mixture is stirred at 60°C for 16 hours. Water is added and the mixture is extracted with ethyl acetate (3 times). The organic phase is washed with brine (twice), dried with MgS04 and concentrated in vacuo. The residue is placed on a plug of silica gel and eluted with ethyl acetate/heptane (1:4) and concentrated in vacuo to give 16.0 g 4-(2-bromo-phenyl)-butyronitrile (91%) as an oil. 300 mL concentrated HCI is added to 4-(2-bromo-phenyl)-butyronitrile (16.0 g, 71 mmol) in 150 mL acetic acid. The reaction mixture is stirred at 60°C for 16 hours. The reaction mixture concentrated in vacuo partly and is poured into water. The mixture is extracted with ethyl acetate (3 times). The organic phase is washed with brine (twice), dried with MgS04 and concentrated in vacuo to give the title compound as a crystalline material. Non-specific uptake is determined using talsupram (10 final concentration), Duloxetine is included as reference in all experiments as dose-response curve. Measurements of ['Jdopamine uptake into rat cortical synaptosomes Tissue preparation: male wistar rats (125-250 g) are sacrificed by decapitation and striatum quickly dissected out and placed in ice cold 0,40 M sucrose. The tissue is gently homogenised (glass teflon homogeniser) and the P2 fraction is obtained by centrifugation (1000 g, 10 minutes and 40000 g, 20 minutes, 4°C) and suspended in 560 volumes of a modified Krebs-Ringer-phosphate buffer, pH 7.4. Tissue 0,25 mg/weU(140 (original tissue) is mixed with test suspension. After 5 minutes pre-incubation at room temperature, 12.5 nM ['H]-dopamine is added and the mixture is incubated for 5 minutes at room temperature. Final volume is 0,2 mL. The incubation is terminated by filtering the samples under vacuum through Whatman GF/C filters with a wash of 1 x 0,2ml buffer. The filters are dried and appropriate scintillation fluid (Optiphase Supermix) is added. After storage for 2 hours in the dark the content of radioactivity is determined by liquid scintillation counting. Uptake is obtained by subtracting the non-specific binding and passive transport measured in the presence of 100 of benztropin.- For determination of the inhibition of uptake ten concentrations of drugs covering 6 decades are used. 'H-DA = 3,4-(ring-2,5,6-'H)doparaine hydrochloride from New England Nuclear, specific activity 30-50 Ci/mmoi. Hyttel, Biochem. Pharmacol. 1978, 27, 1063-1068; Hyttel, Prog. Neuro-Psychopharmacol. & bil. Psychiat 1982, 6, 277-295; Hyttel & Larsen, Acta Pharmacol. Tox. 1985, 56, suppi, 1,146-153. CLAIMS 1. The present invention relates to a compound represented by the general formula IV wherein R "R are independently selected from hydrogen, C1-6"alk(en/yn)yl, C31-cycloalk(en)yl, and C3_8-cycloalk(en)yl-C1-6-alk(en/yn)yl; or R1 and R1 together with the nitrogen form a 4-7 membered ring containing zero or one double bond, optionally said ring in addition to said nitrogen comprises one further heteroatom selected from oxygen and sulphur; R1-R1 and R1-R11 are independently selected from hydrogen, halogen, c-yano, nitro, C1-6-alk(en/yn)yl, C3.8-cycloalk(en)yl, C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, amino, C1-6-alk(en/yn)ylamino, di-(C1-6-alk(en/yn)yl)amino, C1-6-alk(en/yn)ylcarbonyl, aminocarbonyl, C1-6-alk(en/yn)ylaminocarbonyl, di-(C1-6-alk(en/yn)yl)aminocarbonyl, hydroxy, C1-6-alk(en/yn)yloxy, C1-6-alk(en/yn)ylsulfanyl, halo-C1-6-alk(en/yn)yl, halo-C1-6-alk(en/yn)ylsulfonyl, halo-C1-6-alk(en/yn)ylsulfanyl and C1-6-alk(en/yn)ylsulfonyl; R'1 is selected from hydrogen, C1-6-alk(en/yn)yl, C3.8-cycloalk(en)yl and C3.8-cycloalkCen)yl-C1-6-alk(en/yn)yl; m, n, o and p are independently 0 or 1 with the proviso that when m+ n + o + p equals to 1 then none of X, Y, Z and Q are CHa; wherein R1"'- R1 are independently selected from the group consisting of C1-6-alk(en/yn)yl, C3-8-cycloalk(en)yl and C3-8-cycioalk(en)yl-C1-6-alk(en/yn)yI; as the free base or a salt thereof, 2. A compound according to claim 1 wherein R1 and R1 are independently selected from hydrogen and C1-6-alk(en/yn)yl or wherein R and R together with the nitrogen form a 4-7 membered ring containing zero or one double bond, optionally said ring in addition to said nitrogen comprises one further heteroatom selected from oxygen and sulphur. 3. A compound according to any one of claims 1 and 2 wherein R1-R1 and R1-R11 are independently selected from hydrogen, halogen, nitro, C1-6-alk(en/yn)yl, di-(Ci1- alk(en/yn)yI)amino, Ci1-alk(en/yn)yloxy and C1-6-alk(en/yn)ylsulfonyl. 4. A compound according to claim 3 wherein R1-R1 are independently selected from hydrogen, halogen and C1-6-alk(en/yn)yloxy. - _ .. 5. A compound according to claim 3 wherein R -R are independently selected from hydrogen, halogen, nitro, C1-6-alk(en/yn)yl, di-(C1-6-alk(en/yn)yl)amino, C1-6-alk(en/yn)yloxy and C1-6"alk(en/yn)ylsulfonyl. 6. A compound according to any one of claims 1-5 wherein R1 is selected from hydrogen and C1-6-alk(en/yn)yl. 7. A compound according to any one of claims 1-6 wherein X, Y, Z and Q are CHa. 8. A compound according to any one of claims 1-7, said compounds being selected from I 9. A pharmaceutical composition comprising a compound according to any one of claims 1-8 and at least one pharmaceutically acceptable carrier or diluent. 10. Use of a pharmaceutical composition according to claim 9 for the inhibition of the serotonin transporter. 11. Use according to claim 10 for the treatment of a disease or disorder wherein a serotonin reuptake inhibitor is beneficial. 12. Use of a pharmaceutical composition according to claim 9 for the inhibition of the serotonin and noradrenaline transporters. 13. Use according to claim 12 for the treatment of a disease or disorder, wherein a combined serotonin and norepinephrine reuptake inhibitor is beneficial. 14. Use of a pharmaceutical composition according to claim 9 for the inhibition of the serotonin and dopamine transporters. 15. Use according to claim 14 for the treatment of a disease or disorder, wherein a combined serotonin and dopamine reuptake inhibitor is beneficial. 16. Use of a pharmaceutical composition according to claim 9 for the inhibition of the serotonin, noradrenaline and dopamine transporters. « 17. Use according to claim 16 for the treatment of a disease or disorder, wherein a combined serotonin, norepinephrine and dopamine reuptake inhibitor is beneficial 18. Use according to any one of claims 11, 13,15 and 17, wherein said disorder or disease is an affective disorder. 19. Use according to claim 18, wherein the affective disorder is a depressive disorder such as major depressive disorder, postnatal depression, dysthymia or depression associated with bipolar disorder, alzheimers, psychosis or parkinsons. 20. Use according to claim 18, wherein the affective disorder is an anxiety disorder such as general anxiety disorder, social anxiety disorder, post traumatic stress disorder, obsessive compulsive disorder, panic disorder, panic attacks, specific phobias, social phobia and agoraphobia. 21. Use according to any one of claims 13 and 17, wherein said disorder or disease is a pain disorder such as fibromyalgia syndrome, overall pain, back pain, shoulder pain, headache as well as pain while awake and during daily activities. 22. Use according to any one of claims 13 and 17, wherein said disorder or disease is attention deficit hyperactivity disorder. 23. Use according to any one of claims 13 and 17, wherein said disorder or disease is stress urinary incontinence.

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5809-CHENP-2007 AMENDED CLAIMS 30-07-2014.pdf

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