Title of Invention	COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE PCSK9 GENE
Abstract	The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the PCSK9 gene (PCSK9 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the PCSK9 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by PCSK9 gene expression and the expression of the PCSK9 gene using the pharmaceutical composition; and

Title of Invention

COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE PCSK9 GENE

Abstract

The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the PCSK9 gene (PCSK9 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the PCSK9 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by PCSK9 gene expression and the expression of the PCSK9 gene using the pharmaceutical composition; and

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Patent Number

269138

Indian Patent Application Number

6166/CHENP/2008

PG Journal Number

41/2015

Publication Date

09-Oct-2015

Grant Date

01-Oct-2015

Date of Filing

12-Nov-2008

Name of Patentee

ALNYLAM PHARMACEUTICALS, INC.

Applicant Address

300 THIRD STREET, CAMBRIDGE, MASSACHUSETTS 02142

Inventors:

#	Inventor's Name	Inventor's Address
1	TAN, PAMELA	KALTE MARTER 8, 8, 95326 KULMBACH,
2	BRAMLAGE, BIRGIT	JOHANN-ECK-STR. 11, 95326, KULMBACH,
3	FRANK-KAMENETSKY, MARIA	8 FAIRBANKS ST., APT. #3, BROOKLINE, MA 02446,
4	FITZGERALD, KEVIN	40 WILLIAMS STREET, APT. 202, BROOKLINE, MASSACHUSETTS 02446
5	AKINC, AKIN	286 CEDAR STREET, NEEDHAM, MA 02494
6	KOTELIANSKI, VICTOR E.	4 CHARLESGATE EAST, APT. 405, BOSTON, MASSACHUSETTS 02115

PCT International Classification Number

C12Q1/68

PCT International Application Number

PCT/US2007/068655

PCT International Filing date

2007-05-14

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1	60/829,914	2006-10-18	U.S.A.
2	60/840,089	2006-08-25	U.S.A.
3	60/817,203	2006-06-27	U.S.A.
4	60/901,134	2007-02-13	U.S.A.
5	60/799,458	2006-05-11	U.S.A.