| Title of Invention | PIPERIDINE DERIVATIVES AS HUMAN PAPILLOMA VIRUS INHIBITORS |
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| Abstract | ABSTRACT PIPERIDINE DERIVATIVES AS HUMAN PAPILLOMA VIRUS INHIBITORS HPV inhibitors with formula (I) where Gl represents a hydrocarbonated bond or chain possibly substituted by one or two alkyl groups, G2 represents a group (see formula la+Ib) or R represents a hydrogen, an alkyl, halogenoalkyl, or a prodrug radical such as carbamate, acetyl or dialkylaminomelhyl, G represents a bond or a hydrocarbonated chain possibly substituted by one or two alkyls, W represents an oxygen or sulphur, Rl and R2 each represent a group chosen from among hydrogen, halogen, hydroxyl, thio, alkoxy, halogenoalkoxy, alkylthio, halogenoalkyithio, amino, monoalkylamino, dialkylamino, cycloalkyl, alkyl or halogenoalkyi, R3 represents an acid or a prodrug radical of the acid function or a bioisostere of the acid function, A represents an aryl, cycloalkyl, cycloalkenyl or a heterocycle, each possibly substituted, and B represents an aryl or a heterocycle with 6 chains, each possibly substituted, and pharmaceutically acceptable salts. |
| Full Text | PIPERIDINE DERIVATIVES AS HUMAN PAPILLOMA VIRUS INHIBITORS The present invention relates to novel antiviral compounds directed against the papilloma virus, to pharmaceutical compositions containing them, to their preparation method and synthesis intermediates as well as to their use for treating or preventing an infection by the papilloma virus. The papilloma viruses are non-encased viruros, the genome of which is formed by double strand DNA of about 8 kb. They are very widespread in nature and cause epithelial lesions in human as well as in many animals including rabbits, horses, dogs, and bovine species. More than a hundred human papilloma viruses (HPV) have been described. They are classified depending on their infection sites. About 30 HVP have been isolated from anogenital mucosas (cervix uteri, vagina, valva, penis, anus, rectum). The other HPVs are associated with skin lesions. The HPVs with cutaneous tropism include i.a., HPV1, HPV2, HPV3, HPV4, HPV5, HPV7, HPVS, HPV9, HPV10, HPV12, HPV14, HPV15, HPV17, HPV19, HPV20, HPV21, HPV22, HPV23, HPV24, HPV25, HPV26, HPV27, HPV28, HPV29, HPV38, HPV41, HPV4 7, HPV4 9. They are associated with lesions such as warts (verruca vulgaris, verruca plantaris, myrmecia wart, surface wart, verruca plana...) and diseases such as epidermo-dysplasia verruciformis. The mucogenital type HPVs are involved in laryngeal and anogenital diseases including certain cancers. They are often classified as high risk HPVs and low risk HPVs, with reference to the type of lesions with which they are associated. The low risk HPVs include, i.a., HPV6, HPVll, HPV13, HPV32, HPV34, HPV40, HPV42, HPV43, HPV44, HPV53, HPV54, HPV55, HPV57, HPV58, HPV74, HPV91. The low risk HPVs are associated with benign lesions such as condylomas (genital warts such as acuminated condylomas and plane condylomas), laryngeal, conjunctive or buccal papillomas or other epithelial lesions such as intra-epithelial neoplasias of low grade or recurrent respiratory papillomatoses, and more rarely bowenoid papuloses or high grade intra¬epithelial neoplasias or carcinomas. High risk HPVs --include i.a., HPV16, HPV18, HPV31, HPV33, HPV35, HPV39, HPV45, HPV51, HPV52, HPV56, HPV59, HPV61, HPV62, HPV66, HPV67, HPV6 8, HPV72. They are involved in low grade intra-epithelial lesions which may develop into higher grade lesions right up to cancers, in particular cervix uteri cancer and other anogenital cancers. Genital infections by HPVs are the most frequent sexually transmitted infections in the world, including in the developed countries with more than 20 million people infected in the United States. Prevalence of HPV infections varies from 3-42% depending on the countries and affects 10-20% of the sexually active population in industrialized countries. In part of this population, the infection persists and may lead to cancers in the case of high risk HPVs. The prevalence of genital warts (condylomas) is estimated to be 1-2% in the sexually active population of industrialized countries, i.e. about 3,500,000 new cases every year in these countries and 28,000,000 worldwide. Genital warts may be found on parts of the body comprising the anus, vulva, vagina, cervix uteri and penis or peripheral bodies thereto. Treatments of genital warts are based on several strategies, from physical destruction (cryotherapy, C02 laser, electro-surgery, surgical excision), application of cytotoxic agents (TCA, podophyllin, podofilox) right up to the application of immuno-modulator agents (interferon, imiquimod}. However, none of these methods completely eliminates all the viral particles, and significant rates of recurrence, accompanied by severe secondary effects are observed with present therapeutic strategies. This reinforces a need for new strategies for controlling or eliminating infections by papilloma viruses. Unlike what exists in the treatment of other viral diseases, such as those caused by HIV, herpes viruses or influenza viruses, to this day there is no antiviral treatment which specifically targets viral pathogens which the papilloma viruses are. The papilloma viruses infect multistratified epitheliums and their viral cycle is closely related to organogenesis of theses organs and to differentiation of keratinocytes. After infection, the viral genome is present and replicated in a small number in basal cells of the epithelium. As the cells gradually differentiate, the expression of the viral genes and the number of copies of the viral genome increase until expression of the genes of the viral capsid and formation of infectious virions in totally differentiated keratinocytes. The genome of HPVs potentially codes for about ten proteins. The earliest expressed proteins, El and E2, are involved in the replication of the viral genome and the regulation of the expression of the viral genes. The other early proteins of these viruses (E4, E5, E6, E7) have functions in relationship with cell proliferation or roles which are not yet completely explained. The existence of E3 and E8 proteins is still uncertain. Late proteins LI and L2 are those which form the viral capsid. The only 2 viral proteins required and sufficient for replicating HPVs are El and E2 . They are capable of forming an E1/E2 complex and of binding on the replication origin (Ori) of the HPVs, a sequence contained in the viral genome and bearing close sites recognized by El and by E2 . E2 is capable of binding with very high affinity to the E2 sites whereas El, alone, does not have very high affinity for El sites. The interaction between El and E2 increases binding of El on Ori by cooperative binding to DNA. Once it is bound to DNA, El no longer interacts with E2 but forms a hexamer. The helicase and ATPase activities of El allow unfolding of the viral DNA which is then replicated by the cell replication mechanism. The inventors have sought to develop small molecules which inhibit replication of HPVs, preferably with a low risk, by notably interfering with the formation of the complex between the El and E2 proteins. A solution was found by elaborating novel derivatives. The object of the present invention is these novel derivatives, their synthesis, as well as their use in pharmaceutical compositions capable of being used in preventing and treating pathologies related to inhibition of HPV replication, such as for example, HPV1, HPV2, HPV3, HPV4, HPV5, HPV7, HPVS, HPV9, HPVl0, HPV12, HPV14, HPV15, HPV17, HPV19, HPV20, HPV21, HPV22, HPV23, HPV24, HPV25, HPV26, HPV27, HPV28, HPV29, HPV38, HPV41, HPV4 7, HPV4 9, HPV6, HPV11, HPV13, HPV3 2, HPV34, HPV40, HPV42, HPV43, HPV44, HPV53, HPV54, HPV55, HPV57, HPV58, HPV74, HPV91, HPV16, HPV18, HPV31, HPV33, HPV3 5, HPV3 9, HPV45, HPV51, HPV52, HPV56, HPV59, HPV61, HPV62, HPV66, HPV67, HPV68, HPV72 preferably low risk HPVs such as HPVS, HPV11, HPV13, HPV32, HPV34, HPV4 0, HPV4 2, HPV43, HPV44, HPV53, HPV54, HPV55, HPV57, HPV58, HPV74, HPV91. The novel derivatives, objects of the present invention, are active against the papilloma virus. They are also capable of inhibiting E1/E2 interaction. Within the scope of the present invention, the following definitions are provided: "Alkyl" or "Alk" means a monovalent or divalent, linear or branched, saturated hydrocarbon chain, comprising 1- 6 carbon atoms such as the methyl, ethyl, propyl, isopropyl, tertbutyl, methylene, ethylene, propylene group... "Acyl" means a -COR group wherein R is an alkyl group as defined earlier or a phenyl group, for example an acetyl, ethylcarbonyl, benzoyl group... "Acylamino" means a -NHC(0)R group wherein R is an alkyl group as defined earlier. "Acylaminoalkyl" means a -AlkNHC(0)R group wherein Alk and R are alkyl groups as defined earlier. "Alkoxy" means a -OAlk group wherein Alk is an alkyl group as defined earlier. Alkoxy comprises for example methoxy, ethoxy, n-propyloxy, t ert-butyloxy,... "Aryl" means an aromatic monocyclic or bicyclic system comprising 4-10 carbon atoms, it being understood that in the case of a bicyclic system, one of the rings has an aromatic character and the other ring is aromatic or unsaturated. Aryl comprises for example phenyl, naphthyl, indenyl, benzocyclobutenyl goups, ... "Heterocycle" means a saturated, unsaturated or aromatic, fused, spiro-fused or bridged monocyclic or bicyclic system with 3-12 members, comprising 1-4 heteroatoras, either identical or different, selected from oxygen, sulfur and nitrogen, and possibly containing 1 or 2 oxo or thioxo groups, it being understood that in the case of a bicyclic system, one of the rings may have an aromatic character and the other ring is aromatic or unsaturated. Heterocycle comprises for example the piperidyl, piperazyl, furyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, pyridyl, pyrimidyl, pyrazinyl, pyradizinyl, benzofuryl, benzothienyl, indolyl, quinolyl, isoquinolyl, benzodioxolyl, benzodioxinyl, benzo[1,2,5]thiadiazolyl, benzo[1,2,5]oxadiazolyl, [1,2,3]triazolyl, [1, 2 , 4] triazolyl groups, ... "Alkylthio" means a -SAlk group wherein Alk is an alkyl group as defined earlier. Alkylthio comprises for example methylthio, ethylthio, isopropylthio, heptylthio,... "Arylalkyl" means a -Alk-Ar group wherein Alk represents an alkyl group as defined earlier and Ar represents an aryl group as defined earlier. "Halogen atom" means a fluorine, bromine, chlorine or iodine atom. "Cycloalkyl" means a saturated, fused or bridged monocyclic or bicyclic system comprising 3-12 carbon atoms such as the cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, adamantyl, decalinyl, norbornyl group,... "Cycloalkenyl" means an unsatured fused or bridged monocyclic or bicyclic sytern comprising 3-12 carbon atoms such as the cyclopropenyl, cyclobutenyl, cyclopentenyl, cyclohexenyl group,... "Monoalkylamino" means a -NHAlk group wherein Alk is an alkyl group as defined earlier. "Dialkylamino" means a -NAlkAlk' group wherein Alk and Alk' each represent independently of each other an alkyl group as defined earlier. "Monoalkylamide" means a -C(0)NHAlk group wherein Alk is an alkyl group as defined earlier. "Dialkylamide" means a -C(0)NAlkAlk' group wherein Alk and Alk' each represent independently of each other an alkyl group as defined earlier. "N-cycloalkyl" means a cycloalkyl radical as defined earlier comprising a nitrogen atom, bound to the remainder of the molecule through this atom. N- cycloalkyl for example comprises the piperid—1—yl or pyrrol id-1-yl group. "N-cycloalkenyl" means a cycloalkenyl radical as defined earlier, comprising a nitrogen atom, bound to the remainder of the molecule through this atom- N-cycloalkenyl for example comprises the tetrahydropyridin-1-yl group. "Haloalkyl" means a linear or branched saturated hydrocarbon chain comprising 1-6 carbon atoms and substituted with 1-6 halogen atoms such as the trif luoromethyl, 2,2, 2-trif luoroethyl group,... "Haloalkoxy" means a branched or linear saturated hydrocarbon chain comprising 1-6 carbon atoms and substituted with 1-6 halogen atoms, said chain loeing bound to the compound through an oxygen atom, sudh as the trif luoromethoxy, 2,2, 2-trif luoroethoxy group ,... "Haloalkylthio" means a linear or branched saturated hydrocarbon chain comprising 1-6 carbon atoms and substituted with 1-6 halogen atoms, said chain Ipeing attached through a sulfur atom, such as the trifluoromethylthio group,... "Protective Group" or "protection group" means the group which selectively blocks the reactive site in a multifunctional compound so that a chemical reaction may be selectively carried out at another non-protected reactive site, in the sense conventionally associated with the latter in synthesis chemistry. "Isomerism" means compounds which have identical molecular formulae but which differ by nature or iri the binding sequence of their atoms or in the arrangement of their atoms in space. Isomers which differ in the arrangement of their atoms in space are designated by "stereoisomers". Stereoisomers which are not mirror images of each other are designated by "diastereoisomers" and stereoisomers which are non-superposable images in a mirror are designated by "enantiomers" or optical isomers. "Stereoisomers" refer to racemates, enantiomers and diastereoisomers. "Pharmaceutically acceptable" me. ens that which is generally secure, non-toxic, and which is not biologically undesirable, both for veterinary use and for human pharmaceutical use. "Pharmaceutical acceptable salts" of a compound means salts which are pharmaceutically acceptable as defined herein and which have the desired pharmacological activity of the parent compound. It should be understood that all references to pharmaceutically acceptable salts comprise the solvent addition forms (solvates) or crystalline forms (polymorphous forms) such as defined herein, of the same acid or base addition salts. A review of pharmaceutically acceptable salts is notably described in J. Pharm. Sci., 1977, 66, 1-19. "Pharmaceutically acceptable acids" mean non-toxic acid salts derived from organic or mineral acids. Among pharmaceutically acceptable acids, mention may be made in a non-limiting way, of hydrochloric, hydrobromic, sulfuric, phosphonic, nitric, acetic, trifluoroacetic, lactic, pyruvic, maIonic, succinic, glutaric, fumaric, tartaric, maleic, citric, ascorbic, oxalic, methane-sulfonic , camphoric , benzoic , toluene sulfonic acids ,... "Pharmaceutically acceptable bases" mean non-toxic basic salts derived from organic or mineral bases, formed when an acidic proton present in the parent compound is replaced by a metal ion or is coordinated to an organic base. Among pharmaceutically acceptable bases, mention may be made in a non-limiting way to sodium hydroxide, potassium hydroxide, lithium hydroxide, calcium hydroxide, triethy1amine, tertbutylamine, diethylaminoethanol, ethanolamine, ethylenediamine, dibenzylethylenediamine, piperidine, pyrrolidine, morpholine, piperazine, benzylamine, arginine, lysine, histidine, glucosamine, quaternary ammonium hydroxides,... By "prodrug" is meant a chemical derivative of the compound, object of the present invention, which generates in vivo said compound by a spontaneous chemical reaction with the physiological medium, notably by an enzymatic reaction, a photolysis and/or a metabolic reaction. By "prodrug radical of the acid function" is meant a labile functional group which will generate in vivo an acid function upon being separated from the compound, obj ect of the present invention, by a spontaneous chemical reaction with the physiological medium, notably by enzymatic reaction, photolysis and/or metabolic reaction. The prodrug radicals with an acid function notably comprise ester, pivoyloxymethyl, acetoxymethyl, phthalidyl, indanyl, methoxymethyl or 5-R-2-oxo-l,3-dioxolen-4-ylmethyl groups. Other examples are described in T. Higuchi and V. Stella, "Pro-drugs as Novel Delivery Systems", Vol. 14, A.C.S. Symposium Series, American Chemical Society (1975) and "Bioreversible Carriers in Drug Design: Theory and Application", edited by E. B. Roche, Pergamon Press: New York, 14-21 (1987) . In the present patent application, chemical compounds are named according to the IUPAC (The International Union of Pure and Applied Chemistry) nomenclature. The object of the present invention is compounds of f o rmula (I) : (1) as well as their stereoisomers, wherein: Gi represents a bond or a saturated or unsaturated, branched or linear hydrocarbon chain comprising 1-4 carbon atoms, optionally substituted with one or two alkyl groups, preferably identical, haloalkyl group, or a prodrug radical such as a carbamate, acetyl, dialkylaminomethy1 or -CH2-0-CO-Alk, • G represents a bond or a saturated or unsaturated, linear or branched hydrocarbon chain comprising 1-4 carbon atoms, optionally substituted with one or two alkyl groups, preferably identical, • W represents an oxygen, sulfur atom or NH, Ri and R2 either identical or different, each represent a group selected from a hydrogen atom, a halogen atom, a hydroxy1, thio, alkoxy, haloalkoxy, alkylthio, haloalkylthio, amino, monoalkylamino, dialkylamino, cycloalkyl, alkyl or haloalkyl group, R3 represents an acid group or a prodrug radical of the acid function such as an ester, or else a bioisoster of the acid function such as a tetrazol^, phosphonate, phosphonamide, sulfonate or sulfonamide, A represents an aryl, cycloalkyl, cycloalkenyl group or a heterocycle, each optionally substituted, and B represents an aryl group or a 6-membered heterocycle, each optionally substituted, as well as their pharmaceutically acceptable salts, A as defined earlier may be substituted with one or two groups, either identical or different, selected from: • a hydrogen atom, a halogen atom, • an alkoxy, alkylthio, haloalkoxy, haloalkylthio, hydroxy1, thio, cyano, amino, monoalkylamino, or dialkylamino group, • an -SOnR', -COR', -C02R', -OCOR', -CONR'R", -NR'COR" or -NR'S02R" group, wherein R' and R" each represent independently of each other a hydrogen atom, an alkyl, haloalkyl group, and n has the value 1 or 2, • an alkyl or haloalkyl group, the alkyl group being optionally substituted with a cyano, amino, monoalkylamino, dialkylamino or acylamino group, • an aryl, arylalkyl, -X-aryl, -X-arylalkyl or -Alk-X-aryl group wherein X represents -0-, -NH- , -N(Alk)-, -N(COCH3) - , -S-, -SO-, -S02-, -CO- or -CONH-, each substituted on the aryl portion with one or two substituents, either identical or different, selected from: ■S a hydrogen atom or a halogen atom, S an alkyl, haloalkyl, alkoxy, haloalkoxy, thio, alkylthio, haloalkylthio, hydroxy1, cyano, acyl, amino, monoalkylamino or dialkylamino, acid, ester, amide, mono- or di-alkylamide group, S an -SOnR' , -COR' , -C02R' , -OCOR' , CONR'R', -NR'COR' or -NR'S02R': group, wherein R' and R' ' each represent independently of each other a hydrogen atom, an alkyl, haloalkyl group and n has the value 1 or 2, • a heterocycle, -Alk-heterocycle, -X- heterocycle, -X-Alk-heterocycle, or -Alk-X- heterocycle group, wherein X represents -0-, -NH-, -N(Alk)-, -N(COCH3) - , -S- , -SO-, -S02- , -CO-, or -CONH-, each optionally substituted on the heterocycle portion with one or two substituents either identical or different, selected from: •/ a hydrogen atom or a halogen atom, •f an alkyl, haloalkyl, alkoxy, haloalkoxy, thio, alkylthio, haloalkylthio, hydroxyl, cyano, acyl, amino, monoalkyl-or dialkylamino, acid, ester, amide, mono- or di-alkylamide, or ■/ a -SOnR' , -COR', -C02R' , -OCOR', CONR'R', -NR'COR' or NR'S02R' group, wherein R' and R' ' each represent independently of each other a hydrogen atom, an alkyl, haloalkyl group and n has the value 1 or 2, • a cycloalkyl, -Alk-cycloalkyl, cycloalkenyl, -Alk-cycloalkenyl, -X-cycloalkyl, -X-Alk-cycloalkyl, -X-cycloalkenyl, -X-Alk-cycloalkenyl, -Alk-X-cycloalkyl, -Alk-X-cycloalkenyl group, wherein X represents -0-, -NH-, -NfAlk)-, -NfCOCH,)-, -S-, -SO-, -S02-, -CO- or -C0NH-, each optionally substituted on the cyclic portion with one or two substituants , either identical or different, selected from: •f a hydrogen atom or a halogen atom, •f an alkyl, haloalkyl, alkoxy, haloalkoxy, thio, alkylthio, haloalkylthio, hydroxy1, cyano, acyl, amino, monoalkylamino or dialkylamino, acid, ester, amide, mono- or di-alkylamide, or oxo or, S -S0rLR' , -COR' , -C02R' , -0C0R' , CONR'R', -NR'COR' or NR'S02R' group, wherein R' and R' ' each represent independently of each other a hydrogen atom, an alkyl, haloalkyl group and n has the value 1 or 2, B as defined earlier may be an aryl or 6-membered heterocycle, substituted in the ortho position with a R4 group and optionally substituted with a R5 group, wherein: • R4 represents: S an alkyl, -NHAlk, -NAlkAlk', -NHcycloalkyl or -NAlkcycloalkyl group, Alk and Alk' being identical or different, •/ a cycloalkyl, cycloalkenyl, N-cycloalkyl or N-cycloalkenyl group, each optionally substituted with one or two substituents, either identical or different, selected from a hydrogen atom, a halogen atom, an alkyl, haloalkyl, alkoxy, haloalkoxy, thio, alkylthio, haloalkylthio, hydroxyl, cyano, acyl, amino, monoalkylamino or dialkylamino, acid, ester, amide, mono- or dialkylamide, oxo or -X-aryl group and wherein X represents -0-, -NH-, -N(Alk)-, -N(C0CH3) - , -S- , -SO-, -S02-, -CO- or -CONH-, or •f an aryl group optionally substituted with one or two substituents, either identical or different, a hydrogen atom, a halogen atom, an alkyl, haloalkyl, alkoxy, haloalkoxy, thio, alkylthio, haloalkylthio, hydroxyl, cyano, acyl, amino, monoalkylamino or dialkylamino, acid, ester, amide, mono or dialkylamide or -X-aryl group, wherein X represents -0-, -NH-, -N(Alk)-, -N(C0CH3) -, -S-, -SO-, -S02-, -CO- or -C0NH-, • R5 represents: ■/ a hydrogen atom or a halogen atom, S a hydroxyl, alkoxy, haloalkoxy, thio, alkylthio, haloalkylthio, amino, monoalkylamino, dialkylamino, -NHacyl, cyano, acyl, acid, ester, amide, monoalkylamide or dialkylamide group, •f an alkyl or haloalkyl group, the alkyl group may be substituted with a cyano, hydroxyl, alkoxy, acid or ester group, S a -S0nAlk, -S0nHH2, -S0nNHAlk or S0nNAlkAlk' group, wherein n has the value of 1 or 2 and Alk and Alk' are either identical or different, or S a piperidine, oxopiperidine, morpholine group or else a piperazine group optionally substituted with an alkyl or acyl group, The preferred compounds are the compounds of formula (I) wherein: Gi represents a bond or a saturated or unsaturated, linear or branched hydrocarbon chain comprising 1-4 carbon atoms, optionally substituted with one or two alkyl groups, preferably identical, haloalkyl group, or a prodrug radical such as carbamate, acetyl, dialkylaminomethyl or -CH2-0-CO-Alk, • G represents a bond or a hydrocarbon chain comprising 1-4 carbon atoms, linear or branched, saturated or unsaturated, optionally substituted with one or two alkyl groups, preferably identical, and • W represents an oxygen, sulfur atom or NH, Ri and R2 either identical or different, each represent a group selected from a hydrogen atom, a halogen atom, a hydroxy1, thio, alkoxy, haloalkoxy, alkylthio, haloalkylthio, amino, monoalkylamino, dialkylamino, cycloalkyl, alkyl or haloalkyl group, R3 represents an acid group or a prodrug radical of the acid function such as ester, or else a bioisoster of the acid function such as tetrazole, phosphorate, phosphonamide, sulfonate or sulfonamide, A represents an aryl or heterocycle group, each being optionally substituted with one or two groups, either identical or different, selected from: • a hydrogen atom, a halogen atom, • an alkoxy, alkylthio, haloalkoxy, haloalkylthio, hydroxy1, thio, cyano, amino, monoalkylamino or dialkylamino group, • a -SOnR' , -COR'-, -C02R' , -OCOR' , -CONR'R' ' , -NR'COR' or -NR'S02R' group, wherein R' and R' each represent independently of each other a hydrogen atom, an alkyl, haloalkyl group, and n has the value 1 or 2, • an alkyl or haloalkyl group, the alkyl group being optionally substituted with a cyano, amino, monoalkylamino, dialkylamino or acylamino group, • an aryl, arylalkyl, -X-aryl group, wherein X represents -0-, -NH-, -N(Alk)-, -N(C0CH3) -, -S-, -SO-, -S02-, -CO- or -C0NH- group, each substituted on the aryl portion with one or two substituents, either identical or different, selected from: •S a hydrogen atom or a halogen atom, S an alkyl, haloalkyl, alkoxy, haloalkoxy, thio, alkythio, haloalkylthio, hydroxy1, cyano, acyl, amino, monoalkylamino or di-alkylamino, acid, ester, amide, rnono-or dialkylamide group, or ■/ a -S0nR' , -COR', -C02R' , -OCOR', CONR' R' ' , -NR' COR' ' or -NR' S02R' ' groups, wherein R' and R' each represent independently of each other a hydrogen atom, an alkyl, haloalkyl group, and n has the value 1 or 2, • a heterocvcle, -X-heterocycle group wherein X represents -0-, -NH-, -N(alk)-, -N(C0CK3)-, -S- , -SO-, -$02-, -CO- or -C0NH-, each optionally substituted on the heterocycle portion with one or two substituents, either identical or different, selected from: S a Hydrogen atom or a halogen atom, •/ an alkyl, haloalkyl, alkoxy, haloalkoxy, thio, alkylthio, haloalkylthio, hydroxy1, cyano, acyl, amino, monoalkylamino or dialkylamino, acid, ester, amide, mono- or di-alkylamide, or S an -S0nR' , -COR', -C02R' , -0C0R' , CONR'R', -NR'COR' or -NR'S02R' group, wherein R' and R' ' each represent independently of each other a hydrogen atom, an alkyl, haloalkyl group, and n ha£ the value 1 or 2, or • a cycloalkyl, cycloalkenyl, -X-cycloalkyl, -X- cycloalkenyl group where X represents -O-, -NH- , -N(Alk)-, -K(COCH-j)-, -S-, -SO-, -S02-, -CO- or -C0NH- group, each optionally substituted on the cyclic portion with one or two substituents either identical or different selected from: •f a hydrogen atom or a halogen atom, S an alkyl, haloalkyl, alkoxy, haloalkoxy, thio, alkylthio, haloalkylthio, hydroxy1, cyano, acyl, amino, moiioalkyl amino or dialkylamino, acid, ester, amide, mono- or di-alkylamide, or oxo, or ■/ an -S0nR' , -COR' , -C02R' , -0C0R' , CONR'R', -NR'COR' or -NR'S02R' group, wherein R' and R' ' each represent independently of each other a hydrogen atom, an alkyl, haloalkyl group, and n has the value 1 or 2, and B represents a phenyl or pyridine group: substituted in the ortho position with an N-cycloalkyl group such as piperidine or with a cyclohexyl, each optionally substituted with one or two substltuents either identical or different, selected from a hydrogen atom, an alkyl, haloalkyl, alkoxy, haloalkoxy, -X-aryl group, where X represents -0-, -NH-, -N(Alk)-, -N(COCH3>-, -S-, -SO-, -SO2-, -CO- or -CONH-, and/or optionally substituted with a halogen atom or with an alkyl or haloalkyl group. The compounds which are still more preferred are :he compounds of formula (I) wherein: Ji represents a bond or a saturated or unsaturated, .inear or branched, hydrocarbon chain comprising 1-4 :arbon atoms, optionally substituted with one or two Llkyl groups, preferably identical, haloalkyl group or a prodrug radical such as a carbamate, acetyl, dialkylaminomethyl, or - CH2-0-CO-Alk, • G represents a bond or a saturated or unsaturated, linear or branched hydrocarbon chain comprising 1-4 carbon atoms, optionally substituted with one or two alkyl groups, preferably identical, and • W represents an oxygen, sulphur atom or NH-, Ri and R2 either identical or different, each represent a group selected from a hydrogen atom, a halogen atom, a hydroxy1, thio, alkoxy, haloalkoxy, alkylthio, haloalkylthio, a^ino, monoalkylamino, dialkylamino, cycloalkyl, alkyl or haloalkyl group, R3 represents an ^cid group or a prodrug radical of the acid function such as an ester, or else a bioisoster of the acid functioh such as a tetrazole, phosphonate, phosphonamide, sulfonate or sulfonamide, A represents an aryl group optionally substituted with one or two groups, either identical or different, selected from: • a hydrocjen atom, a halogen atom, • an ^Ikoxy, alkylthio, haloalkoxy, haloalkyithio, hydroxyl, thio, cyano, amino, monoalkylamino or dialkylamino group, • an -S0n£', -COR', -C02R\ -OCOR1, -CONR'R", -NR'COR" or -NRS02R" group, wherein R' and R' each represent independently of each other a hydrogen atom, an alkyl, haloalkyl group, £nd n has the value 1 or 2, • an alkyl or haloalkyl group, the alkyl group being optionally substituted with a cyano, amino, monoalkylamino, dialkylamino, or acylamii^o group, • an aryl, arylalkyl, -X-aryl group, wherein X represents -0-, -NH-, -N(Alk)-, -N(COCH3)-, -S_ ( _S0-, -SO,-,-, -CO- or -CONH-, each substituted on the aryl portion with one or two svibstituents, either identical or different, selected from: S a liydrogen atom or a halogen atom, •/ an alkyl, haloalkyl, alkoxy, haloalkoxy, thio, alkythio, haloalkylthio, hydroxyl, cygino, acyl, amino, monoalkylamino or dialkylamino, acid, ester, amide, mono-or di-alkylamide group, or ■S an -SOnR' , -COR', -C02R' , -OCOR' , CONR'R', -NR'COR' or -NR'S02R' group, wherein R' and R' ' each represent independently of each other a hydrogen atom, an alkyl, haloalkyl group, and n has the value 1 or 2, • a heterocycle, -X-heterocycle group, wherein X represents -0-, -NH-, -N(Alk)-, -N(COCH3)-, -S-, -SO-, -S02-, -CO- or -CONH-, es--?h optionally substituted on the heterocycle portion with one or two substituents, either identical or different, selected from: S a hydrogen atom or a halogen atom, S an alkyl, haloalkyl, alkoxy, haloalkoxy, thio, alkylthio, haloalkylthio, hydroxyl, cyano, acyl, amino, monoalkylamino or dialkylamino, acid, ester, amide, mono- or di-alkylamide, or S an -SO..R', -COR', -C02R' , -OCOR', CONR'R', -NR'COR' or -NR'S02R' group, wherein R' and R' ' each represent independently of each other a hydrogen atom, an alkyl, haloalkyl group, and n has the value 1 or 2, or • a cycloalkyl or -X-cycloalkyl group, wherein X represents -0-, -NH-, -N(Alk)-, -N(C0CH3)-, -S-, -SO-, -S02-, -CO- or -C0NH-, each optionally substituted on the cyclic portion with one or two substituents, either identical or different, selected from a hydrogen atom, a halogen atom, an alkyl, haloalkyl, alkoxy, haloalkoxy, thio, alkylthio, haloalkylthio, hydroxyl, cyano, acyl, amino, monoalkylamino or di alkylamino, acid, ester, amide, mono- or di-alky1amide or oxo group, and B represents a phenyl or pyridine group: substituted in the ortho position with a N-cycloalkyl group such as piperidine or with a cyclohexyl, each optionally substituted with one or two substituents, either identical or different, selected from a hydrogen atom, an alkyl, haloalkyl, alkoxy, haloalkoxy, -X-aryl, -wherein X represents -0-, -NH-, -N(Alk)-, N(C0CH3)-, -S-, -SO-, -S02-, -CO- or -C0NH- group, and/or optionally substituted with a halogen atom or with an alkyl, or haloalkyl group. The more preferred compounds are the compounds of formula (I) wherein: Gi represents a bond or a saturated or unsaturated, linear or branched hydrocarbon chain comprising 1-4 carbon atoms, optionally substituted with one or two alkyl groups, preferably identical, preferably a bond or a hydrocarbon chain comprising one integer comprised between 1 and 4 and m is an integer having the value 1 or 2, preferably n has the value 1 or 2 , Rj represents an alkoxy group, such as methoxy, preferably in the ortho position relatively to R-,, R2 represents a hydrogen or halogen atom, such as chlorine or bromine, or an alkyl group, such as methyl, preferably in the meta position relatively to R3l R3 represents an acid or ester group, A represents an aryl group such as a phenyl, preferably substituted: - in the meta or para position with: • a halogen atom or an alkyl, haloalkyl, cyano, alkoxy, haloalkoxy, acylaminoalkyl group or an -XR group, wherein X represents -0-, -NH-, -N(Alk)-, -N(COCH3)-, -S-, -SO-, -S02-, -C0-or -CONH- group, and R represents an arylalkyl, cycloalkyl or aryl group, each optionally substituted with one or two substituents, either identical or different, such as a halogen atom, an alkoxy, alkyl, haloalkyl, cyano, acyl, amino, monoalkylamino or dialkylamino, acid, ester, amide, mono- or di-alkylamide group, or an -SOnR', -OCOR', -NR'-COR' or -NR'S02R' group, wherein R' and R" each represent independently of each other a hydrogen atom, an alkyl, haloalkyl group, and n has the value 1 or 2, or • a cycloalkyl, aryl, arylalkyl group or heterocycle, preferably N-cycloalkyl, each optionally substituted with one or two substituents, either identical or different, such as a halogen atom, an alkoxy, alkyl, haloalkyl, cyano, acyl, amino, monoalkylamino or dialkylamino, acid, ester, amide, mono- or di-alkylamide group, or an -SOnR' , -OCOR' , -NR'COR', or -NR'S02R"' group, wherein R'and R' each represent independently of each other a hydrogen atom, an alkyl, haloalkyl group and n has the value 1 or 2, - and/or in the ortho or meta position with an alkyl group, and B represents an aryl group, preferably a phenyl, • substituted in the ortho position with a heterocycle, preferably a N-cyloalkyl, such as piperidine group, and/or • substituted in the ortho' position with an alkyl group, such as a methyl. The more preferred compounds are the compounds of formula (I) wherein: Gi represents a bond or a saturated on unsaturated, linear or branched hydrocarbon chain comprising 1-4 carbon atoms, optionally substituted with one or two alkyl groups, preferably identical, preferably a bond or a hydrocarbon chain comprising 1 or 2 carbon atoms, wherein n is an integer comprised between 1 and 4 and m is an integer having the value 1 or 2, preferably n has the value 1 or 2, Ri represents an alkoxy group, such as methoxy, preferably in the ortho position relatively to R3, Ra represents a hydrogen or halogen atom such as chlorine or bromine, or an alkyl group, such as methyl, preferably in the meta position relatively to R3, Rs represents an acid or ester group, A represents an aryl group, such as phenyl, preferably substituted: - in the meta or para position with: * a halogen atom or a cyano, alkoxy, haloalkoxy, acylaminoalkyl or -XR group, wherein X represents -0-, -S-, -SO-, -S02-, or -CO- and R represents an arylalkyl, cycloalkyl or aryl group, each optionally substituted with one or two substituents, either identical or different, such as a halogen atom, an alkoxy or acyl group, or • a cycloalkyl, aryl or arlyalkyl group, each optionally substituted with one or two substituents, either identical or different, such as an acyl or alkoxy group, and - and/or in the ortho or meta position with an alkyl group, and B represents an aryl group, preferably a phenyl, • substituted in the ortho position with a heterocycle, preferably a N-cycloalkyl, such as a piperidine group, and/or • substituted in the ortho' position with an alkyl group, such as a methyl. The more preferred compounds are the compounds of f o rmula (I> whe rein: Gi represents a bond or a saturated or unsaturated, linear or branched hydrocarbon chain comprising 1-4 carbon atoms, optionally substituted with one or two alkyl groups, preferably identical, preferably a bond or a hydrocarbon chain comprising 1 wherein n is an integer comprised between 1 and 4, preferably n has the value 1, Ri represents an alkoxy group, such as methoxy, preferably in the ortho position relatively to Rit R2 represents a hydrogen or halogen atom, such as chlorine or bromine, or an alkyl group, such as methyl, preferably in the meta position relatively to R3, R3 represents an acid or ester group, A represents an aryl group, such as a phenyl, preferably substituted in the meta or para position with: • a halogen atom or a alkoxy, haloalkoxy, or -XR group, wherein X represents -0- and R represents an arylalky1, cycloalkyl or aryl group, each optionally substituted with one or two substituents, either identical or different, such as a halogen atom, an alkoxy or acyl group, or" • a cycloalkyl, aryl or arlyclkyl group, each optionally substituted with one or two substituents, either identical or different, such as an acyl group, and B represents an aryl group, preferably a phenyl, • substituted in the ortho position witJi a heterocycle, preferably a N-cycloalkyl, such as a piperidine group, and/or • substituted in the ortho' position with an slkyl group, such as a methyl. Still more preferred compounds are grouped in Tabl^ I: The obj ect of the present invention is also the pharmaceutical compositions comprising at least one compound of formula (I) , associated with a pharmaceutical^ acceptable excipient. The pharmaceutical compositions according to the invention may be compositions which may be administered into the organism via any administration route. In an non-exhaustive way, the administration route of the pharmaceutical compositions according to the invention may be topical, enteral or parenteral, preferably a buccal, conjunctive, cutaneous, endotracheal, intradermal, intra-epidermal, intramuscular, intravascular, laryngeal, nasal, ophthalmic, oral, rectal, respiratory, sub-cutaneous, transcutaneous or vaginal administration. It is generally advantageous to formulate such pharmaceutical compositions as a single dose. Each dose then comprises a predetermined amount of the active ingredient, associated with the vehicle, suitable excipients and/or adjuvants, calculated in order to obtain a given therapeutic effect. As an example of a single dose which may be administered via an oral route, mention may be made of tablets, gelatin capsules, granules, powders and oral solutions or suspensions. As an example of single dose which may be administered via a topical route (notably for local treatment of external genital and perianal warts), mention may be made of ovules, gels, creams, lotions, solutions and patches. The suitable formulations for the selected dosage forms are known and described for example in Remington, The Science and Practice of Pharmacy, 19th edition, 1995, Mack Publishing Company and may therefore be easily prepared by one skilled in the art. It is known that dosage varies from one individual to the other, depending on the nature and the intensity of the disease, the selected administration route, the weight, the age, and the sex of the patient ; accordingly the effective dosages should be determined according to these parameters by the specialist in this matter. As an indication, the effective dosages may range between 1 and 50 0 mg daily. The obj ect of the present invention is also the use of the compounds of formula (I) for treating or preventing an infection by the papilloma virus, preferably in humans. The obj ect of the present invention is also the use of the compounds of formula (I) for inhibiting the replication of the papilloma virus by inhibiting the formation of the E1/E2 protein complex. The object of the present invention is further the use of the compounds of formula (I) for preparing a drug intended for treating or preventing infection by the papilloma virus, preferably in humans. The obj ect of the present invention is in particular the use of compounds of formula (I) for preparing a drug intended for treating or preventing infection by a low risk papilloma virus, such as HPV6, HPV7, HPV11, HPV13, HPV32, HPV34, HPV40, HPV42, HPV43, HPV44, HPV53, HPV54, HPV55, HPV57, HPV58, HPV74, HPV91. The object of the present invention is in particular the use of compounds of formula (I) for preparing a drug intended for treating or preventing an infection by HPV6 and/or HPV11. Thus, the object of the present invention is also the use of compounds of formula (I) for preparing a drug intended for treating or preventing Ice ions and diseases associated with infections by the papilloma virus. The object of the present invention is in particular the use of compounds of formula (I) for preparing a drug intended for treating and preventing anogenital warts, such as acuminated condylomas and plane condylomas, laryngeal, conjunctive or buccal papillomas and other epithelial lesions such as respiratory recurrent papillomatoses and intra-epithelial neoplasias of low grade and of high grade, bowenoid papuloses, warts (verruca vulgaris, verruca plantaris, myrmecia wart, surface warts, verruca plana...) , epidermodysplasia verruciformis, carcinomas, in particular anogenital carcinomas, and all the lesions which are associated with the papilloma virus. The object of the present invention is in particular the use of compounds of formula (I) for preparing a drug intended for treating or preventing anogenital warts, such as acuminated condylomas and plane condylomas, laryngeal, conjunctive or buccal papillomas and other epithelial lesions, such as respiratory recurrent papillomatoses and low grade intra-epithelial neoplasias and all the lesions which are associated with the papilloma virus. The compounds, objects of the present invention, may be prepared according to the various synthesis routes described hereafter. represents a sulfur atom in formula (I) . Lawesson's reagent may for example be [2,4-bis(4-methoxyphenyl)1,3-dithia-2,4-diphosphetane-2,4-disulfide (Lawesson et al. Bull. Soc. Chim Belg. 1978, 87, 229) . In the case when Gx represents a bond, the compounds of formula (II) may be obtained from compounds of formula wherein A, B and Gj are as defined earlier; The compounds of formulae (IX) and (XII) are put into the presence of sodium nitrite in an acid medium and then reduced by a hydride, for example lithium aluminium hydride {J Org. Chem. 1953, 18, 971, J Org. Cnem. 1954, 19, 1157, and J Am. Chem. Soc. 1952, 74, 3192) in order to obtain the compounds of formula (II) as defined earlier. In the case when R2 represents a hydrogen or bromine atom, the compounds of formula (III) may be obtained according to methods of the literature (J" Med. Chem. 1998, 41, 5219 or WO 0135900). In the case when R2 represents a chlorine atom, the compounds of formula (III) may be obtained by reacting sulfuryl chloride in an acid medium with a precursor of The compounds of formulae (VII), (VIII), (X) and (XI) are either commercial compounds or compounds obtained according to known methods of organic synthesis easily accessible and easily understood by one skilled in the art . In the preferred case when B is a phenyl substituted with a piperidine, compounds of formula (I) may be prepared according to the following synthesis route. The compounds of formula (XV) are reduced by tin chloride in a polar medium (Tet. Lett. 1984, 25 (8), 839) and then reacted with a dibromoalkane, for example dibromopentane in a basic and apolar medium (Bioorg. Med. Chem. Lett. 1996, 6 (5) , 563) leading to the The compounds of formula (XVI) and (XVirr) are put into the presence of sodium nitride in an acid medium and then reduced by a hydride, for example lithium aluminium hydride in order to obtain the compounds of formula (II) as defined earlier. In the particular case when A represents a substituted phenyl and G2 is a bond, the compounds of formula (I) may be prepared according to the following synthesis route. The compound of formula (XIX) is reacted: Next, the compound (XXI) is reacted under basic saponification conditions in order to lead to the compound of general formula (I). When W represents an oxygen atom, the ester precursors of the compounds of formula (I) are obtained from the The compounds of formula (XXVI) are reduced by-catalytic hydrogenation and then reacted with a dibromoalkane or an acid chloride, for example 5-foromovaleryl chloride, in a basic and apolar medium, and then cyclized in a basic and polar medium such as by sodium hydride in dimethylformamide and finally reduced by borane, in order to lead to the compound of formula (XXVII): c 5 The starting products used are commercial products or products prepared according to known operating procedures from commercial compounds or known to one skilled in the art. The different preparations lead to synthesis intermediates useful for preparing the 10 compounds of the invention. The structures of the compounds described in the examples and in the preparations were determined according to the usual spectrophotometry techniques (nuclear magnetic resonance (NMR), mass spectrometry 5 (MS), including electrospray (ES), melting point (MP)-) and purity was determined by high performance liquid chromatography (HPLC) and confirmed by elementary analysis. 10 Abbreviations used in the operating procedures: • AIBN: 2,2' azobis(2-methylpropionitrile) • TIJC : thin layer chromatography • EDCI: 1-(3-dimethylaminopropyl)-3-ethylcarbo-diimide hydrochloride 15 • DMAP: 4-dimethylaminopyridine • DMSO: dimethylsulfoxide • DIPEA: N, W-diisopropylethylamine • HOBt: 1-hydroxybenzotriazole • TFA: trifluoroacetic acid 20 Preparation 1: methyl 4-carboxymethyl-2-methoxy-benzoate Methyl 4-carboxymethyl-2-methoxy-benzoate may be prepared according to the method described in J Med. 25 Chem. 1998, 41, 5219 or patent WO 0135900. Preparation 2: methyl 5-bromo-4-carboxymethyl-2-methoxy-benzoate Methyl 5-bromo-4-carboxylmethyl-2-methoxy-benzoate is 30 obtained from the preparation 1 according to the procedure described in WO 013 5900. Preparation 3: methyl 5-chloro-4-carboxymethyl-2-methoxy-benzoate To 300 mg of methyl 4-carboxymethyl-2-methoxy-ben3oatf from preparation 1 placed in 6 mL of acetic acid, are added 110 uL of sulfuryl chloride (1 equivalent) . The whole is refluxed for 6 hours. After evaporation of he solvent, the reaction crude product is purified on silica gel (petroleum ether/ethyl acetate: 80/20 then 60/40) leading to 165 mg of the desired compound. Yield: 47% HPLC: 96% MS: MH+ 259/261 Preparation 4: methyl 4-((E) -2-carboxy-vinyl)-2-methoxy-benzoate Stage 1: methyl 4-bromomethyl-2-methoxy-benzoate To 5.38 g of methyl 2-methoxy-4-methyl benzoat£ in 2 0 mL of carbon tetrachloride, are added 5.3 g of N- bromosuccinimide (1 equivalent) and 490 mg of AIBN (0.1 equivalent) away from direct light. The whole is refluxed by heating overnight. The reaction medium is evaporated under reduced pressure and then purified on silica gel (petroleum ether/ethyl acetate: 90/10) leading to 3.73 g of the desired product. Yield: 48% :H NMR HPLC: 96% MS: MH' 259/261 Stage 2: methyl 4-Hydroxymethyl-2-methoxy-benzoate To 1.5 g of the product obtained in the previous stage in 25 mL of dioxane is added a suspension of 2.55 g (4.4 equivalents) of calcium carbonate in 25 mL> of water. The whole is heated for 6 hours at 100 °C. After evaporation of the reaction medium, the crude product is taken up in dichloromethane, acidified with a 1 N hydrochloric acid solution. The reaction medium is extracted several times with dichloromethane, the collected organic phases are then dried on magnesium sulfate, filtered and evaporated under reduced pressure, leading to 1.10 g of the desired product. Yield: 96% XH NMR (CDC13, 300 MHz) 5 (ppm): 7.78 (d, 1H), 7.01 (m, 1H), 6.93 (d, 1H>, 4.73 (s, 2H), 3.91 (s, 3H), 3.88 (s, 3H) Stage 3: methyl 4-formyl-2-methoxy-benzoate To 1.10 g of the product obtained in the previous stage in 20 mL of dioxane are added 4.87 g of activated manganese oxide (10 equivalents). The whole is stirred at room temperature for 24 hours, and then filtered on celite. The filtrate is evaporated under reduced pressure and the obtained residue is purified by chromatography on silica gel (petroleum ether/ethyl acetate: 90/10 and then 80/20) leading to 540 mg of the desired product. Yield: 50% lH NMR (CDC1}, 300 MHz) 5 (ppm) : 10.02 (s, 1H), 7.89 (d, 1H), 7.48 (m, 2H), 3.97 (s, 3H), 3.92 (s, 3H) Stage 4: methyl 4-((E)-2-tert-butoxycarbonyl-vinyl)-2-methoxy-benzoate To 720 pL of tert-butyl diethylphosphonoacetate (1.1 equivalents) in 3 mL of tetrahydrofurane cooled to 0°C under an inert atmosphere are added 307 mg of sodium tert-butanolate (1.15 equivalents). The whole is stirred for 3 0 minutes at 0°C and then for 1 hour at room temperature. A solution cooled to 0-4 °C of 540 mg of aldehyde obtained in stage 3 in 1 ml of tetrahydrofurane is added dropwise to the previous mixture also cooled to 0°C. Stirring is maintained at this temperature for 30 minutes before letting the temperature rise t>ack to room temperature for 2 hours. The medium is hydrolyzed with a saturated solution of ammonium chloride and extracted with ethyl acetate several times. The collected organic phases are washed with water, and then dried on magnesium sulfate, filtered and evaporated under reduced pressure. The reaction crude product is purified by chromatography on silica gel (petroleum ether/ethyl acetate: 95/5) leading to 500 mg of the expected product. Yield: 61% *H NMR (DHSO, 300 MHz) 5 fppm): 7.48-7.66 (bulk aromatic, 3H) , 6.70 (d, 1H) , 3.87 (s, 3H) , 3.79 (s, 3H> , 1.49 (S, 9H) HPLC: 93% MS: MH+ 2 93 Stage 5: methyl 4^((E)-2-carboxy-vinyl)-2-methoxy-benzoate To 100 mg of diester obtained in the previous stage in 1 .6 mL of dichloromethane are added 0 .8 mL of trifluoroacetic ac^id. The whole is stirred for one hour at room temperature and then evaporated under reduced pressure with a toluene and dichloromethane mixture as co-solvents. Yield: 99% *H NMR (DMSO, 300 MHz) 5 (ppm): 7.57-7.67 (m, 2H), 7.47 (s, 1H), 7.32 (d, 1H), 6.67 (d, 1H), 3.87 (s, 3H), 3.79 (s, 3H) HPLC: 9 0% Preparation 5: methyl 5-bromo-4-((£)-2-carboxy-vinyl)- 2-methoxy-benzoate Stage 1: methyl 5-bromo-4-bromomethyl-2-methoxy- henzoate To 2.5 g of methyl 2-methoxy-4-methyl benzoate in 15 mL of acetic acid are added dropwise 550 \ih of bromine (1.1 equivalents) at room temperature. The whole is stirred for one night, until complete disappearance of the starting product (tracked by TLC). The reaction medium, hydrolyzed by a 1 N soda solution, is extracted with ethyl acetate. The organic phases are dried on magnesium sulfate and then concentrated under reduced pressure, leading to 2.72 g of a pale yellow oil which crystallizes. Yield: 83% lU NMR (CDC13, 300 MHz) 5 (ppm): 7.98 (s, 1H), 7.05 (s, 1H), 4.55 (s, 2H), 3.92 (s,3H), 3.89 (s, 3H) HPLC: 85% MS: MH+ 336/338/340 Stage 2: methyl 5-bromo-4-hydroxymethyl-2-methoxy-benzoate The product (880 mg> is obtained according to the method of stage 2 of preparation 4 from 1.3 g of product from the previous stage in the presence of 1.7 g of calcium carbonate. Yield: 83% *H NMR (CDC13, 300 MHz) 5 (ppm): 7.96 (s, 1H), 7.20 (s, 1H), 4.75 (s, 2H), 3.92 (s, 3H), 3.88 (s, 3H> HPLC: 96% MS: MH' 275/277 Stage 3: methyl 5-bromo-4-formyl-2-methoxy-benzoate The product (72 5 mg> is obtained according to the method of stage 3 of preparation 4, by using 875 rrtg of the previous alcohol in the presence of 2.8 cj of activated manganese oxide. Yield: 83% :H NMR {CDCl-i, 3 00 MHz) 5 (ppm) : 10.33 (s, 1H), 8.01 (S, 1H), 7.49 (s, 1H), 3.95 (s, 3H}, 3.92 (s, 3H) HPLC: 96% MS: MH+ 273/275 . Stage 4: m&thyl 5-bromo-4-((E)-2-tert-butoxycarbonyl-vinyl) -2-methoxy-benzoate The product (860 mg) is obtained according to the method of stage 4 of preparation 4, by using 725 mg of the previous aldehyde in the presence of 688 uP of tert-butyl diethylphosphonoacetate and 2 93 mg of sodium tert-butanolate. Estimated yield: 87% XH NMR (CDCIJS, 300 MHz) 5 (ppm): 8.00 (s, 1H) , 7.89 (d, 1H) , 1 .13 [S, \Vi) , 6.34 td, 1H> , 3.92 \s, VA) , 3.39 \s, 3H), 1.55 (s, 9H) HPLC: 63% MS: MH+ 371/373 Stage 5: methyl 5-bromo-4-((E)-2-carboxy-vinyl)-2-methoxy-benzoate The product (489 mg) is obtained according to the method of stage 5 of preparation 4, by using 860 mg of the previous cinnamic ester in the presence of 5 mL of trifluoroacetic acid. Yield: 67% 2H NMR (DMSO, 300 MHz) 5 (ppm): 7.88 (s, 1H), 7.75 (d, 1H), 7.57 (s, 1H), 6.83 (d, 1H), 3.90 (s, 3H), 3.80 (s, 3H) HPLC: 89% MS: MH* 315/317 Example 1: 5-brcimo-2-methoxy-4- [N- (4-methoxy-phenyl) -N- (2-piperidin-l-yl-phenyl)-hydrazinocarbonylmethyl]-benzoic acid hydrochloride {1} Stage 1: (4-metho^y-phenyl)-(2-nitro-phenyl)-amine To 3.7 mL of 2-fluoro-nitrobenzene are added 8.73 g of 4-methoxyaniline (2 equivalents). The whole is heated to 110 °C overnight. The medium is taken up in ethyl acetate, successively washed with water, a saturated solution of sodium bicarbonate and then with a saturated solution of sodium chloride. The organic phase is dried on magnesium sulfate, filtered and then concentrated under reduced pressure. With silica gel chromatography of the residue (petroleum ether/ethyl acetate: 90/10) 8.63 g of the desired product are isolated. Yield: 99% LH NMR (DMSO, 300 MHz) 5 (ppm): 9.35 fs, 1H), 8.10 (d, 1H), 7.45 (t, 1H), 7.25 (d, 2H) , 6.98 (m, 3H), 6.79 (t, 1H), 3.78 (S, 3H) HPLC: 100% Stage 2: N-(4-metftoxy-phenyl)-benzene-1,2-diamine To a solution of 4 g of the product obtained in the previous stage in 80 mL of ethanol are added 18.5 g of tin chloride hydrate (5 equivalents). The whole is refluxed for 5 hrS and then stirred at room temperature overnight. The medium is hydrolyzed under cold conditions, adjusted to a pH of 8 with a saturated solution of sodiutf bicarbonate and extracted with ethyl acetate several times. The collected organic phases are dried on magnesium sulfate, filtered and evaporated in vacuo. The obtained residue is purified by silica gel chromatography (toluene and then toluene/ethyl acetate: 95/5) leading to 2.9 g of the expected product. Yield: 82% XH NMR (DMSO, 300 MHz) 5 (ppm): 6.89 (d, 1H), 6.75 HPLC: 100% Stage 3: (4-methoxy-phenyl)-(2-piperidin-l-yl-phenyl)-amine To a solution de 2.5 g of aniline obtained earlier in 15 TTIL of toluene, are successively added 2.47 g z? de sodium carbonate (2 equivalents) and 1.6 mL of dibromopentane (1 equivalent) . The whole is refluxed for 24 hrs. After returning to room temperature, the sodium carbonate is removed by filtration and rinsed with dichloromethane. The filtrate is evaporated under reduced pressure. The obtained residue is purified by silica gel chromatography (petroleum ether, petroleum ether/ethyl acetate: 98/2) leading to 1.72 g of the desired product. Yield: 52% JH NMR (CDC15, 300 MHz) 5 (ppm): 7.10 (m, 4H), 6.93 (m, 3H), 6.78 (m, 1H), 6.5 2 (s, 1H), 3.81 (s, 3H), 2.86 (m, 4H), 1.71 (m, 4H), 1.60 (m, 2H) HPLC: 100% Stage 4: N- (4-methoxy-phenyl)-N-(2-piperidin-l-yl-phenyl) -hydrazine (a) 806 mg of the product obtained in the previous Stage are solubilized in 10 mL of acetic acid. To this solution cooled between 5 and 15°C is added dropwise a solution of 1.14 g of sodium nitride in 3 mL of water (5.8 equivalents). After 10 minutes of stirring, ice is added into the reaction medium, the formed precipitate is filtered, washed with water and then dried in vacuo. A brc>wn powder corresponding to the nitroso intermediate is obtained (followed by TLC and NMR). This non-purified intermediate, taken up in 8 mL of diethyl ether, is directly cooled to 10°C. To this solution is added a suspension of 119 mg of lithium aluminium hydride (1.1 equivalents) in 2 tnL of diethyl ether. The whole is stirred for 1 hr until complete disappearance of the starting product (tracked by TLC). The reaction medium is poured onto a 1 N soda solution and extracted several times with diethyl ether. The organic? phase is dried, filtered and evaporated under reduced pressure leading to a residue which is purified by chromatography (petroleum ether/ethyl acetate: 95/5). 382 mg of product corresponding to hydrazine are obtained as pink oil. Yield: 45% 2H NMR (CDC13, 300 MHz) 5 (ppm): 7.08 (m, 5H), 6.95 (m, 1H), 6.81 (m, 2H), 3.78 (s, 3H), 3.04 (m, 4H), 1.73 (m, 4H), 1.57 (m, 2H) Stage S' methyl 5-bromo-2-methoxy-4-[N-(4-methoxy-phenyl) -N- (2-piperidin-l-yl-phenyl) -hydrazinocarbonyl-methyl]-benzoate To a solution of 367 mg of the previous compound in 10 mL of dichloromethane are added 412 mg of the acid of the preparation 2 (1.1 equivalents), 260 mg of EDCI (1.1 equivalents) and 45 mg of DMAP (0.3 equivalent). The reaction medium is stirred at room temperature, and if necessary heated, until complete disappearance of the starting hydrazine (time > 15 hrs) and then hydrolyzed and extracted with dichloromethane several times. The organic phases are washed with a 1 N soda solution and then with a saturated solution of sodium chloride, dried on magnesium sulfate, filtered and evaporated under reduced pressure. The obtained residue is purified by silica gel chromatography (petroleum ether/ethyl acetate: 72/25 and then 70/30) leading to 546 mg of the expected product. Yield: 76% lH NMR fDMSO, 300 MHz) 5 (ppm): 10.65 (s, 1H), 7.81 (s, 1H), 7.30 (m, 2H), 6.99 (m, 4H), 6.72 (m, 4H), 3.79 (2s broad, 8H), 3.69 (s, 3H), 2.50 (s broad, 4H) , 1.12 (m, 6H) HPLC: 96% Stage 6: 5-bromo-2-methoxy-4- [N- ( 4-methoxy-phenyl) -N-(2-piperidin- 1-yl-phenyl) -hydrazino-carbonyl-methyl] -benzoic acid hydrochloride (1) To a solution of 100 mg of the product obtained in stage 5, in 2 mL of dioxane are added 343 uL of a 1 N soda solution (2 equivalents). The reaction medium is stirred at room temperature for 4 hrs and then concentrated under reduced pressure. The obtained solid is taken up in a minimum of water and acidified with a 1 N hydrochloric acid solution up to a pH of 1. In the present case, extraction with dichloromethane allows the reaction crude product to be isolated. After evaporation, the residue is taken up in ether. A precipitate is formed which is filtered and washed leading to 52 mg of the expected product as a hydrochloride. Yield: 50% MP: 109 °C (decomposition) Elementary analysis calculated for C28H30BrN3O5.lHCl-l.5H2O: C, 53.22; H, 5.42; N, 6.65. Found: C, 52.84; H, 5.08; N, 6.24. HPLC: 97% MS: MH+ 568/570 Example 2: 5-bromo-2-methoxy-4[N-{2-piperidin-l-yl-phenyl)-N{4-trifluoromethoxy-phenyl)-hydrazinocarbonylmethyl]-benzoic acid hydrochloride{2} Stage 1: (2-Ni tro-phenyl)-(4-fcrifluoromethoxy-phenyl)-amine To 374 \iL of 2-fluoro-nitrobenzene in 2 mL of DMSO are added 962 uL of 4-trifluoromethoxyaniline (2 equivalents) and 636 mg of potassium tert-butanolate (1.6 equivalents) . The whole is heated to 110°C for 3 hrs. Once the reaction is completed, the medium taker, • up in a minimum of dichloromethane is hydrolyzed and then extracted- The organic phase is successively washed with water and then with a saturated solution of sodium chloride, dried on magnesium sulfate, filtered and concentrated under reduced pressure. A silica gel chromatography of the residue (cyclohexane and then cyclohexane/ethyl acetate: 99/1) allows 575 mg of the desired product to be isolated. Yield: 54% 2H NMR (CDC13, 300 MHz) 5 (ppm): 9.43 (s, 1H), 8.22 (d, 1H) , 7.43 (t, 1H) , 7.25-7.38 (m, 4H) , 7.19 (d, 1H) , 6.83 (t, 3H) HPLC: 97% MS: MH+ 299 Stage 2: N- (4-Trifluoromethoxy-phenyl)-benzene-1,2-diamine The product (600 mg) is obtained according to the method of stage 2 of Example 1, by using 570 mg of the previous derivative as a starting product and 2.16 g of tin chloride hydrate in 10 mL of ethanol. Yield: quantitative 2H NMR (CDCl3, 3 00 MHz) 5 (pprn) : 7 .01-7.12 (m, 4H) , 6.73-6.86 (m, 2H) r 6 .70 (m,2H) , 5.30 (s broad, 1H) HPLC: 96% MS: MHT 269 Stage 3: (2-Piperxdin-1-yl-phenyl)-(4-tri£luorometRoxy-phenyl)-amine The product (350 rag) is obtained according to hte method of stage 3 of Example 1, by using 513 mg of the previous aniline as substrate and 261 uL of dibromopentane in the presence of 405 mg of sodium carbonate in 5 mL of toluene. Yield: ^4% 2H NMR (CDClj, 300 MHz) 5 IH), 6.88 (t, 1H), 6.70 (s, 1H), 2.83 (m, 4H), 1.71 (m, 4H), 1.59 (m, 2H) Stage 4: N- (2-Piperidin-l-yl-phenyl)-N- (4-trifluoro-methoxy-phenyl)-hydrazine (b) The product (180 mg) is obtained according to the method of stage 4 of Example 1 by using 3-45 mg of the previous derivative as a starting product and 410 mg of sodium nitrite in 4 mL of acetic acid leading to the nitroso intermediate which is reduced by 2 8 met of lithium aluminium hydride in 4 mL of diethyl ether. Yield: 50% 2H NMR (CDCl^, 300 MHz) 5 (ppm): 7.04-7.22 (bulk aromatic, 8H), 3.09 (m, 4H), 1.83 (m, 4H), 1.59 (m, 2H) MS: MH" 3 52 Stage 5-" methyl 5-bromo-2-methoxy-4 [N- (2-piperidin-l-yl-pheixyl) -N- (4-trifluoromethoxy-phenyl) -hydrazine;^ carbonylniethyl] -benzoate The product (250 mg) is obtained according to the method of stage 5 of Example 1, by using 176 mg of the preceding hydrazine as substrate and 167 mg of the acid of the preparation 2 as a co-substrate in the presence of 106 mg of EDCI and 18 mg of DMAP. Yield: 78% 1H NMR (CDC13, 300 MHz) 5 (ppm) : 9.32 and 9.35 (2s in proportions 70/30, 1H) , 7.93 and 7.99 (2s in proportions 30/70, 1H) , 6.74-7.50 (m, 9H) , 3.70-4.07 (3s, 8H), 2.67 (m, 4H>, 1.43-1.56 To a solution of 100 mg of the product obtained in stage 5 in 2 mL of dioxane is added 1.6 iL of a 1 N soda solution (10 equivalents). The reaction medium is stirred at room temperature for 4 hrs and then concentrated under reduced pressure. The obtained solid is taken up in a minimum of water and acidified with a 1 N hydrochloric acid solution up to a pH of 1. A precipitate is formed, which is filtered, taken up in ether and washed leading to 52 mg of the expected product as a hydrochloride. Yield: 69% MP: 157 °C (decomposition) Elementary analysis calculated for C28H27BrF3N-iO5.lHCl.lH2O: C, 49.68; H, 4.47; N, 6.21. Found: C, 50.01; H, 4.62; N, 5.91. HPLC: 98% MS: MH+ 622/624 Example 3: 5-bromo-2-methoxy-4-[N-(3-methoxy-benzyl)-N-(2-piperidin-1-yl-phenyl)-hydrazinocarbonylmethyl]-benzoic acid hydrochloride (3) Stage 1; (3-methOxy-benzyl) - (2-piperidin-l-yl-phenyl) -amine To 1 g of 2-piperi-dinoaniline in 10 mL of DMF are added 7 95 U-L of 3-methPxybenzyl bromide (1 equivalent} and 1.57 g of potassium carbonate (2 equivalents) . The whole is heated to 100°C for 2-3 hrs, until disappearance of the starting aniline. The medium is poured onto ice aAd then extracted with ethyl acetate. The organic pha^e washed with water is dried on magnesium sulfate, filtered and evaporated under reduced pressure. By silica gel chromatography of the residue (cyclohexEine/ethyl acetate: 99/1) 1.46 g of the desired product may be isolated. Yield: 87% lH NMR (CDC13, 300 MHz) 5 (ppm): 7.26 (m, 1H), 6.99 (m, 4H), 6.81 (d, 1H), 6.68 (t, 1H), 6.57 (d, 1H), 4.35 (s, 2H) , 3.80 fs, 3H) / 2.86 (s broad, 4H) , 1.69 fs broad, 6 H) HPLC: 97% MS: MH+ 29 7 Stage 2: N-(3-Methoxy-benzyl)-N-(2-piperidin-l-yl-phenyl) -hydrazine (c) According to the method of stage 4 of Example 1, the nitroso intermediate (376 mg) is obtained by extraction with ethyl acetate from the reaction medium buffered to pH 7 by using 3 53 mg of the previous derivative as starting product, and 477 mg of sodium nitrite in 3 mL of acetic acid. A suspension of 180 mg of lithium aluminium hydride (4 equivalents) in 5 mL of diethyl ether applied to this intermediate for 2h30 with reflux leads to 138 mg of hydrazine after purification. Yield: 37% 1H NMR (CDCI3, 3 00 MHz) 5 (ppm) : 7.26 (m, 1H) , 6.91-7.11 (bulk aromatic, 6H) , 6.80 (dd, 1H) , 4 .56 (s, 2H) , 3.80 (s, 3H), 3.12 (m, 4H), 1.59-1.7 9 (m, 6H) Stage 3: methyl 5-bromo-2-methoxy—4-[N-(3-methoxy-benzyl)-N- (2-piperidin-l-yl-phenyl)-hydrazinocarbonyl-methyl]-benzoate The product (183 mg) is obtained according to the method of stage 5 of Example 1, by using 137 mg of the previous hydrazine as a substrate and 16 0 mg of the acid of preparation 2 as a co-substrate in the presence of 101 mg of EDCI and 16 mg of DMAP. Yield: 70% HPLC: 100% MS: MH+ 596/598 Stage 4: 5-bromo-2-methoxy-4-[N-(3-methoxy-benzyl)-N-(2-piperidin-l-yl-phenyl)-hydrazinocarbonylmethyl]-benzoic acid hydrochloride (3) The product (152 mg) is obtained as a hydrochloride according to the method of stage 6 of Example 2, by using as a substrate the product obtained in the previous stage. Yield: 82% MP: 109-112 °C Elementary analysis calculated for C29H32BrN305.1HC1.1.5H20: C, 53.92; H, 5.62; N, 6.50. Found: C, 54.08; H, 5.67; N, 5.79. HPLC: 100% MS: MH+ 582/584 Example 4 : 4- [N (4-benzyloxy-ph.enyl) -N (2-piperidin-l-yl-phenyl) -hydrazinocarbonylmethyl]-5-bromo-2-methoxy-benzoic acid hydrochloride (4) Stage 1: (4-Benzyloxy-phenyl)-(2-nitro-phenyl)-amine To 6 00 uL of 2-f luoro-nitrobenzene, 6 mL of DMSO are added 1.7 g of 4-(benzyloxy)aniline (1.5 equivalents) and 1.02 g of potassium tert-butanolate (1.6 equivalents). The whole is heated to 110°C for lh30. The medium is then hydrolyzed and extracted several times with ethyl acetate. The organic phases are washed with a saturated solution of sodium chloride, dried on magnesium sulfate, filtered and then concentrated under reduced pressure. A silica gel chromatography of the residue (cyclohexane/ethyl acetate: 99/1) allows 7 54 mg of the desired product to be isolated. Yield: 41% :H NMR (CDCl3, 300 MHz) 6 (ppm): 9.40 (s broad, 1H), 8.18 (d, 1H), 7.23-7.45 (m, 6H), 7.17-7.21 (m, 2H) , 7.05 (m, 3H) , 6.71 (t, 1H) , 5.09 (s, 2H) MS: MH+ 321 Stage 2: N- (4-Benzyloxy-phenyl)-benzene-1,2-diamine The product (653 mg) is obtained according to the method of stage 2 of Example 1, by using 754 mg of the previous derivative as a starting product and 2.66 g of tin chloride hydrate in 12 mL of ethanol. Yield: 95% XH NMR (CDC13, 3 00 MHz) 5 fppm): 6.68-7.37 (bulk aromatic, 13H), 5.01 (s, 2H) HPLC: 82% MS: MH+ 291 Stage 3: (4-benzyloxy-phenyl)- (2-piperidin-l-yl-phenyl)-amine To a solution of 653 mg of aniline obtained previously in 4 mL of toluene, are successively added 940 uL of DIPEA (2.4 equivalents) and 305 uL of dibromopentane (1 equivalent) . The whole is re fluxed for 2 hrs until complete disappearance of the starting aniline. After returning to room temperature, the reaction medium is hydrolyzed and extracted several times with ethyl acetate. The organic phases are washed with water, dried on magnesium sulfate, filtered and evaporated under reduced pressure. The obtained residue is purified by silica gel chromatography (cyclohexane and then cyclohexane/ethyl acetate: 99.5/0.5) leading to 480 mg of the desired product. Yield: 60% '"H NMR (CDCl!, 300 MHz) 6 (ppm) : 7.31-7.41 (m, 5H) , 7.05-7.15 (m, 4H), 6.95 {m, 3H), 6.78 (t, 3H), 6.53 (s broad, 1H), 5.06 (s, 2H) HPLC: 94% MS: MH+ 35 9 Stage 4: N- (4-benzyloxy-phenyl) -N- (2-piperidin-l-yl-phenyl)-hydrazine (d) The product (2 02 mg) is obtained according to the method of stage 4 of Example 1, by using 488 mg of the previous derivative as a starting product, and 545 mg of sodium nitrite in 5 mL of acetic acid leading to the nitroso intermediate which is reduced by 74 mg of lithium aluminium hydride (2 equivalents) in 5 mL of diethyl ether. Yield: 40% 2H NMR (CDC13, 300 MHz) 6 (ppm): 6.73-7.4 0 (bulk aromatic, 13H) , 4.94 (s, 2H) , 2.90 (m, 4H) , 1.61 (m, 4H), 1.43 et 1.50 (m, 2H) Stage 5: methyl 4-[N- (4-benzyloxy-phenyl)-N-(2-piperidin-1-yl-phenyl)-hydrazinocarbonyl methyl]-5-bromo-2-methoxy-benzoate The product (193 mg) is obtained according to the method of stage 5 of Example 1, by using 2 02 mg of the previous hydrazine as a substrate and 18 0 mg of the acid from preparation 2 as a co-substrate in the presence of 114 mg of EDCI and 20 mg of DMAP. Yield: 54% *H NMR (CDC13, 300 MHz) 5 (ppm) : 9.37 (s broad, m) , 7.98 (d, 1H) , 7.3 0-7.3 7 (m,5H> , 7.05-7.3 0 (m, 2H) , 6.70-6.84 (m, 5H) , 4.99 (d, 2H) , 3.68-4.08 (3s, 8H) , 2.66 (m,4H), 1.43-1.63 (m, 6H) Stage 6: 4- [N- (4-benzyloxy-phenyl)-N- (2-piperidin-i-yi-phenyl) -hydrazirocarbonylmethyl] -5-bromo-2-methoxy-benzoic acid hydrochloride (4) The product is obtained accordi ng to the method of stage 6 of Example 2, by using as a substrate the product obtained in the previous stage. With a purification by reversed phase chromatography (conditions: CI 8 column, 21.2x150 mm, isocratic mode 30% acetonitrile/H20 + 0.05% TFA, flow rate : 15 mL/min, wavelengths : 220 and 254 nm) followed by a tTSS£n?£jit Si'i th 3 1 N hydrochloric acid solution, th& desired product was able to be isolated a.s a hydrochloride (40 mg). Yield: 21% MP: 114 °C HPLC: 98% MS: MH+ 644/646 Example 5: 5-bromo-4-{W[4-{4-fluoro-phenoxy)-phenyl]-N (2-piperidin-1-yl-phenyl) -hydrazinocarbonylmethyl}--2-methoxy-benzoic acid hydrochloride (5) Stage 1: l-Nitro-4-(4-fluoro-phenoxy)-benzene To a solution of 1.5 mL of 4-fluoronitrobenzene in 2 8 mL of dimethylformamide are successively added 1.75 g of 4-fluoronitrobenzene (1.1 equivalents) and 2.15 g of potassium carbonate (1.1 equivalents). The whole is heated to 150 °C for 4h3 0. After returning to room temperature, the medium is poured on ice and put under stirring for 3 0 min. A precipitate is formed which is filtered, rinsed with water and then dried (3.02 g) . Yield: 91% 2H NMR (CDC13, 300 MHz) 5 (ppm) : 8.20 (d, 2H) , 6.97-7.16 (bulk aromatic, 6H} Stage 2: 4-(4-fluoro-phenoxy)-phenylamine To a solution of 3.02 of the product obtained in the previous stage in 50 mL of ethanol are added 14.6 g of tin chloride hydrate (5 equivalents). The whole is refluxed for 1 hr. After returning to room temperature, the medium is poured on ice, basified to a pH of 10 by means of a 4 N soda solution and extracted with ethyl acetate several times. The collected organic phases are dried on magnesium sulfate, filtered and evaporated under reduced pressure leading to 2.6 g of the expected product. Yield: quantitative XH NMR (CDC13, 300 MHz) 5 (ppm): 6.82-7.03 (bulk aromatic, 6H), 6.71-6.79 (m, 2H) MS: MH* 2 04 Stage 3: 14-(4-fluoro-phenoxy)-phenyl]-(2-nitro-phenyl)-amine The product (790 mg) is obtained according to the method of stage 1 of Example 4, by using 900 uL of 2-fluoro-nitrobenzene and 2.6 g of the product obtained in the previous stage in the presence of 1.53 g of potassium tert-butanolate in 9 mL of DMSO. Yield: 28% lU NMR (CDCI3, 300 MHz) 5 (ppm) : 9 .46 (s broad, 1H) , 8.25 {d, 1H), 7.42 (t, 1H), 7.28 (m, 2H), 7.05-7.19 (bulk aromatic, 7H), 6.77 ft, 1H) HPLC: 92% MS: MH+ 325 Stage 4: N-[4-(4-fluoro-phenoxy)-phenyl]-henzene-l,2- diamine The product (637 rag) is obtained according to the method of stage 2 of Example 1, by using 750 mg of the previous derivative as a starting product and 2.61 g of tin chloride hydrate in 12 mL of ethanol. Yield: 93% >H NMR (CDClj, 300 MHz) 5 (ppm): 6.17-7.13 (bulk aromatic, 12H) HPLC: 92% MS: MH+ 2 95 Stage 5: [4~(4-fluoro-phenoxy)-phenyl]-(2-piperidin-l-yl-phenyl)-amine The product (715 mg) is obtained according to the method of stage 3 of Example 4, by using 635 mg of the previous derivative as a starting product, 294 UM of dibromopentane and 905 u.L of DIPEA in 4 mL of toluene. Yield: 91% :H NMR (CDClj, 300 MHz) 6 (ppm): 6.79-7.26 (bulk aromatic, 12H), 6.63 (s broad, 1H), 2.84 (m, 4H), 1.74 (m, 4H) , 1.60 (m, 2H) HPLC: 98% MS: MHT 363 Stage 6: N-[4-(4-fluoro-phenoxy)-phenyl]-N-(2-piperidin-1-yl-phenyl)-hydrazine (e) The product (275 mg} is obtained according to the method of stage 4 of Example 1, by using 715 mg of the previous derivative as a starting product and 791 mg of sodium nitrite in 7 mL of acetic acid leading to the nitroso intermediate which is reduced by 150 mg of lithium aluminiun hydride (2 equivalents) in 7 mL of diethyl ether. Yield: 37% 2H NMR (CDC13, 300 MHz) 5 (ppm) : 6 . 83-7 . 19 (bulk aromatic, 12H) , 3.00 fm, 4H) , 1.73 Cm, 4H) , 1.58 (m, 2H) Stage 7: methyl 5-Bromo-4-{N- [4- (4-fluoro-phenoxy) - phenyl] -N- (2-piperidiv-l-yl-phenyl) -hydras inocarbonylmethyl} -2 -methoxy-benzoate The product (336 mg) is obtained according to the mehtod of stage 5 of Example 1, by using 2 75 mg of the previous hydrazine as a substrate and 24 3 mg of the acid of preparation 2 as a co-substrate in the presence of 154 mg of EDCI and 2 7 mg of DMAP. Yield: 69% :H NMR (CDCl3f 300 MHz) 5 (ppm) : 9.35 (s broad, 1H) , 7.98 (d, 1H), 6.73-7.5 0 (bulk aromatic, 13H), 3.69-4.13 (3s, 8H), 2.72 (m, 4H), 1.4 6-1.60 (m,6H) HPLC: 95% MS: MH' 662/664 Stage 8: 5-bromo-4-{N~[4-(4-fluoro-phenoxy)-phenyl}-N-(2-piperidin-l-yl-phenyl)-hydrazinocarbonylmethyl}-2-methoxy-benzoic acid hydrochloride (5) The product is obtained according to the method of stage 6 of Example 2, by using as a substrate the product obtained in the previous stage. With a purification by reversed phase chromatography of a fraction (conditions: C18 column, 21.2x150 mm, isocratic mode 30% acetonitrile/H20 + 0.05% TFA, flow rate: 15 mL/min, wave lengths 220 and 254 nm) followed by a treatment with a 1 N hydrochloric acid solution, the expected product was able to be isolated as a hydrochloride (43 mg). Estimated yield: 44% MP: 224-23l'C Elementary analysis calculated for C33H3:BrFN305.lHCl.iHj.O: C, 56.38; H, 4.88; N, 5.98. Found: C, 56.28; H, 4.91; N, 5.78. HPLC: 98% MS: MH' 648/650 Example 6 : 5-bronio-2-methoxy-4-{W- [2- (4-methoxi~benyl) -ethyl] -N-(2-piperidin-l-yl-phenyl)-hydrazinocarbonyl-methyl}-benzoic acid hydrochloride (6) Stage 1: [2-(4-Methoxy-phenyl)-ethyl]-(2-piperidin~l-yl-phenyl)-amine To 1 g of 2-piperidinoaniline in 10 mL of DMF are added 1.72 mL of 4-m6thoxyphenethyl chloride (2 equivalents) and 2.35 g of potassium carbonate {3 equivalents). The whole is heated to 100°C for 60 hrs and then poured on ice and extracted with ethyl acetate. The organic phase washed with a saturated solution of sodium chloride is dried on magnesium sulfate, filtered and evaporated under reduced pressure. With several silica gel chromatographies of the residue (petroleum ether, petroleum ether/ethyl acetate: 98/2), 255 mg of the desired product were able to be isolated. yield: 14% ^H NMR (CDCI3, 300 MHz) 6 (ppra): 7.17 (d, 2H), 6.99 (m, 2H) , 6.86 (m, 2H) , 6.66 (m, 2H) , 4.77 (s broad, IH) , 3.80 (s, 3H), 3.36 (t, 2H), 2.90 (t, 2H), 2.72 (s broad, 4H), 1.57 (m, 6H) Stage 2: N-12-(4-methoxy-phenyl)-ethyl]-N~(2-piperidin-l-yl-phenyl) -hydrazine (f) The product (160 mg) is obtained according to the method of stage 4 of Example 1, by using 250 mg of the previous derivative as a starting product and 322 mg of sodium nitrite in 3 mL of acetic acid leading to the nitroso intermediate which is reduced by 103 mg of lithium aluminium hydride (4 equivalents} in 3 mL of tetrahydrofurane with reflux. Yield: 61% ^H NMR (CDClj, 300 MHz) b (ppm): 6.80-7.3 8 (bulk aromatic, 8H), 3.77 (s, 3H), 3.42 (t, 2H), 3.08 (t, .-2H) , 2.93 (m, 4H) , 1.55-1.7 0 (m, 6H) HPLC: 88% MS: MH"* 325 Stage 3 : methyl 5-Bromo-2-methoxy-4-{N- [2- (4-metlioxy-phenyl)-ethyl]-N-(2-piperidin-l-yl-phenyl)-hydrazino-carbonyliae thy I} -benzoa t e To a solution of 160 mg of the previous compound in 3 mL of dimethylformamide, are added 164 mg of the acid of preparation 2 (1.1 equivalents), 104 mg of EDCI (1.1 equivalents) and 73 mg of HOBt (1.1 equivalents). The reaction medium is stirred at room temperature for 30 min and then heated to 40°C for lh30. The reaction crude product is poured on ice and extracted with ethyl acetate several times. The collected organic phases are dried on magnesium sulfate, filtered and evaporated under reduced pressure. A first silica gel chromatography of the residue (petroleum ether/ethyl acetate: 95/5, 80/20 and then 50/50) was able to isolate the product which is then purified by reversed phase chromatography (conditions: Cl8 column, 21.2x150 mm, isocratic mode 30% acetonitrile/H20 + 0.05% TFA, flow rate: 15 mL/min, wavelengths : 220 and 254 nm) leading to 9 0 mg of the desired product as a TFA salt. Yield: 25% ^H NMR (DMSO, 300 MHz) 6 (ppm) : 12,15 [s broad, IH} , 11,53 (s, 1H> , 8.06 (d, IH) , 7.92 (s, IH) , 7.54 (t, IH), 7.42 (m, IH), 7.32 (d, IH), 7.03 (d, 3H), 6.76 (d, 2H) , 3.86 and 3.83 {2s, lOH), 3.73 (s, 2H), 3.47 (s, 3H), 2.98 (m, 2H), 2.8 5 (t, 2H), 1.79 [m, 4H), 1.34 (m, 2H) HPLC: 99% MS: MH" 610/612 Stage 4 : 5-bromo-2-inetho:z2'^-4-{N- [2- (4-iaethoxy~phenyl) - ethyl] -N- (2~piperidin-l-yl-phenyl) -hydrazinocarbonyl- methyl}-benzoic acid hydrochloride (6) The product (63 mg) is obtained as a hydrochloride according to the method of stage 6 of Example 2, by using as a substrate the product obtained in the previous stage. Yield: 68% MP: 162-176 'C Elementary analysis calculated for: C3oH,4BrN305.1HCl .I.5H2O: C, 54.59; H, 5.80; N, S.37. Found: C, 54.65; H, 5.31; N, 5.85. HPLC; 90% MS: MH^ 596/598 Example 7 : 5-broino-2-methoxy-4- [N- (4-methoxy-phenyl) - N- (2~Hiethyl-6-piperidin-l-yl-phenyl) -hydrazinocarbonyl- methyl]-benzoic acid hydrochloride (7) Stage 1: (4-methoxy-phenyl) - (2-i[iethyl-6-nitro-phenyl) - amine The product (487 mg) is obtained according to the method of stage 1 of Example 4, by using 1 g of 2- fluoro-3-methyl-nitrobenzene and 1.19 g of 4- methoxyaniline in the presence of 1.16 g of potassium tert-butanolate in 9 mL of DMSO. Yield: 29% ^H NMR (CDCI3, 300 MHz) 6 (ppm): 7.99 (d, IH), 7.37 (m, IH), 6.96 (t, IH), 6.78 (m, 4H), 3.78 {s, 3H), 1.99 (s, 3H} Stage 2 : N^- (4-inethoxy-phenyl) -3-methyl~benzeDe~l, 2- diamine The product (42 8 rag) is obtained according to the method of stage 2 of Example 1, by using 4 87 mg of the previous derivative as a starting product and 2.13 g of tin chloride hydrate in 6 mL of ethanol. Yield: 99% ^H NMR {CDCI3, 300 MHz) 5 (ppm): 6.99 (t, IH), 6.75 (m, 2H), 6.65 (d, 2H), 6.52 (m, 2H) , 3.74 (s, 3H) , 2.17 (s, 3H) Stage 3: (4~methoxy-phenyl}-(2-methyl-6-pip6ridin-l-yl-phenyl) -amine The product (250 mg) is obtained according to the method of stage 3 of Example 4, by using 4 25 rag of the previous derivative as a starting product, 253 viL of dibromopentane and 778 uL of DIPEA in 8 mL of toluene. Yield: 45% ^H NMR (CDCI3, 300 MHz) 5 (ppm): 6.95 (m, 3H), 6.78 (m, 2H), 6.67 (m, 2H), 3.77 (s, 3H), 2.73 (m, 4H), 2.10 (s, 3H), 1.59 (m, 6H) Stage 4 : N- (4-meth.oxy-phenyl} -N- (2-iaethyl~6-piperidin-1-yl-phenyl)-hydrazine (g) According to the method of stage 4 of Example 1, the nitroso intermediate (270 mg) is obtained by extraction with dichloromethane from the reaction medium buffered to pH 7 by using 250 mg of the previous derivative as a starting product and 337 mg of sodium nitrite in 3 mL of acetic acid. A suspension of 126 mg of lithium aluminium hydride (4 equivalents) in 3 mL of tetrahydrofurane applied to this intermediate for i hr with reflux is able to lead to 129 mg of hydrazine after purification. Yield: 49% MS: MH"" 312 Stage 5: methyl 5-bromo-2-inethoxy-4~ [N- {4-methoxy- phenyl) -N- (2-methyl-6~piperidin-l-yl-phenyl) -hydrazino-carbonylmBthyl]-benzoate fya^ To c solution of 12 9 rag of the acid obtained in preparation 2 (1.1 equivalents) in 4 mL of dichloromethane are added 100 laL of thionyl chloride (3,3 equivalents) and 1 drop of dimethylf ormamide. The whole is stirred for 1 hr at room temperature and then evaporated under reduced pressure. To the thereby obtained acid chloride, taken up in 4 mL of toluene, are successively added a solution of 129 mg of the previous hydrazine in 3 mL of toluene and 6 5 )aL of triethylamine {1.1 equivalents}. The medium is heated overnight to 40°C and then after returning to room temperature, hydrolyzed and extracted with ethyl acetate several times. The collected organic phases are washed with water, dried on magnesium sulfate, filtered and evaporated under reduced pressure. The obtained residue is purified by reversed phase chromatography (conditions : C18 column, 21.2x150 mm, isocratic mode 35% acetonitrile/H20 + 0.05% TFA, flow rates : 15 mL/min, wavelengths : 220 and 254 nm) leading to 110 mg of the expected product as a TFA salt. Yield: 37% ^H NMR (CDCI3, 300 MHz) 5 (ppm) : 12.52 (s broad, IH) , 11.12 (s, IH), 7.98 (s, IH), 7.51 (m, 2H), 7.36 (d, IH), 7.13 (s, IH), 6.79 (d, 2H>, 6.56 (d, 2H), 4.03 (m. 2H), 3,89 [s, 6H), 3.75 (s, 3H), 3.42 (m, 3H}, 3.06 (m, IH), 2.26 (s, 3H), 1.7 9-2.01 (m, 5H), 1,50 (m, IH) HPLC: 93% MS: MH"" 596/598 Stage 6: 5-hromo~2-methoxy-4-[N-(4-methoxy-phenyl}-N-(2-methyl-6-piperidin-l-yl-phenyl)-hydrazinocarbonyl-methyl]-benzoic acid hydrochloride (7) The product (61 mg) is obtained as a hydrochloride according to the method of stage 6 of Example 2, by using as a substrate the product obtained in the previous stage, Yield: 53% MP: 155-168°C Elementary analysis calculated for C29H32BrN305.1HCl .1.75H30: C, 53.55; H, 5.66; N, 5.46. Found: C, 53.28; H, 5.69; N, 6.12. HPLC: 100% MS: MH"" 582/584 Example 8 : 5-broiiio-2-inethoxy-4- IN- (4-methoxy-bensyl} -N-(2-piperidin-l-yl-phenyl)-hydrazinocarbonylmethyl]-benzoic acid hydrochloride (8) Stage 1: (4-methoxy-benzyl) - (2-piperidin-l'-yl-phetiyi) -amine The product (644 mg) is obtained according to the method of stage 1 of Example 3, by using 1 g of 2-piperidinoaniline, 982 yL of 4-methoxybenzyl bromide (1.2 equivalents) and 1.6 g of potassium carbonate (2 equivalents) in 10 mL of DMF. Yield: 40% 'H NMR (CDCI2, 300 MHz) 6 (ppm): 7.42 (d, 2H), 7.11 (m, 2H) , 7.01 (d, 2H) , 6.81 (td, IH) , 6.75 (dd, IH) , 4.41 (s, 2H), 3.88 (s, 3H), 2.99 (s broad, 4H), 1.82 (m, 6H) HPLC: 100% MS: HH* 2 97 Stage 2: N- (4-Methoxy-benzyl) -N- (2-piperidin-l-yl-phenyl)-hydrazine (h) The product (275 mg) is obtained according to the method of stage 4 of Example 1, by using 2 90 rag of the previous derivative as a starting product and 392 mg of sodium nitrite in 3 mL of acetic acid leading to the nitroso intermediate which is reduced by 140 mg of lithium aluminium hydride (4 equivalents) in 4 mL of tetrahydrofurane with reflux. Yield: 90% ^H NMR {CDCI3, 300 MHz) 6 {ppra): 7.23 (ra, 2H), 7.10 (m, IH), 7.0 0 (m, 3H), 6.87 (m, 2H), 4.47 (s, 2H), 3.82 (s, 3H), 3.10 (m, 4H), 1.5 9-1.77 (m, 6H} HPLC: 96% MS: MH^ 312 Stage 3 : methyl 5-bromo-2-iaethoxy-4- [N- (4-iaethoxy~ benzyl) -N- (2-piperidin-l-yl-phenyl) ~-hydrazinocarbonylmethyl]-benzoate The product is obtained according to the method of stage 5 of Example 7, by using 161 mg of the acid of preparation 2 and 116 pL of thionyl chloride in the presence of a drop of dimethylformamide for forming the acid chloride and 150 mg of the previous hydrazine in the presence of 74 i^L of triethylamine for coupling. With a purification by reversed phase chromatography (conditions: CI 8 column, 21.2x150 mm, isocratic mode 35% acetonitrile/HjO + 0.05% TFA, flow rate: 15 mh/min, wavelengths: 220 and 254 nm) 80 mg of the expected product was able to be isolated as a TFA salt. Yield: 23% ^H NMR (CDCI3, 300 MHz) b (ppm): 11.90 (s broad), 10.57 (s, IH) , 8.13 (d, IH) , 7.87 (s, IH) , 7.63 (t, IH) , 7.48 (t, IH), 7.34 (d, IH), 7.12 (d, 2H), 6.76 (m, 3H), 4.47 (m, 2H) , 3.89 (m, IH) , 3.78, 3.86 and 3.89 (3s, 9H) , 3.64 (s, 2H), 2.95-3.15 (m, 3H}, 1.93 and 2.09 (2m, 5H), 1.49 (m, IH) HPLC: 93% MS: MH* 596/598 Stage 4 : 5-hromo-2-meth.oxy-4- [N- (4-inethoxy-benzyX) -N-(2-piperidin-1-yl-phenyl) -hydrazinocarbonylmethyl] -benzoic acid hydrochloride (8) The product (36 mg) is obtained as a hydrochloride according to the method of stage 6 of Example 2, by using as a substrate the product obtained in the previous stage. Yield: 43% MP: 140-171 °C Elementary analysis calculated for CagH^aBrNjOs. IHCl .1 . 75H;iO: C, 53.55; H, 5.66; N, 6. 46. Found: C, 53.52; H, 5.58; N, 5.97. HPLC: 98% MS: MH"" 582/584 Example 9: 5-bromo-4-[N- (4-cyclohexyl-phenyl)-N-{2-piperidin-1-yl-phenyl)-hydrazinocarbonylmethyl]-2-methoxy-benzoic acid hydrochloride (9) Stage 1: (4-cyclohexyl-phenyl)-(2-nitro~phenyl)-amine The product (280 mg) is obtained according to the method of stage 1 of Example 4, by using 400 )_iL of 2-fluoro-nitrobenzene and 1 g of 4-eyelohexylaniline in the presence of 683 mg of potassium tert-butanolate in 4 mL of DMSO. yield: 25% ^H NMR (CDCI3, 300 MHz) 5 (ppm) : 9.47 (s broad, IH) , 8.19 (d, IH) , 7.71 (d, IH) , 7.4 5 (t, IH) , 7.34 (t, IH) , 7.10-7.24 (m, 3H> , 6.71 (t, IH) , 2.53 (m, IH) , 1.3 5-1.95 (2m, lOH) HPLC: 87% MS: MH"" 2 97 Stage 2: N- (4-cyclohexyl-phenyl)-benzene-1,2-diamin& The product {154 mg) is obtained according to the method of stage 2 of Example 1, by using 280 mg of the previous derivative as starting product and 1.07 g of tin chloride hydrate in 4 mL of ethanol. Yield: 61% 'H NMR (CDCI3, 300 MHz) 6 (ppm) : 6.95-7.12 (m, 4H) , 6.68-6.82 (m, 4H) , 2.40 (m, IH) , 1.40 and 1.80 (2m, lOH) HPLC: 91% MS: MH"" 267 Stage 3: (4-eyelohexyl -phenyl) - (2-piperidin~l-yl- phenyl)-amine The product (395 mg) is obtained according to the method of stage 3 of Example 4, by using 700 mg of the preceding derivative as a starting product, 357 yL of dibronopentane and 1.1 raL of DIPEA in 10 mL of toluene. Yield: 45% 'H NMR (CDCI3, 300 MHz) & (ppm): 7.30 (m,IH), 7.05-7.16 (m, 5H), 6.97 (t, IH), 6.80 (t, IH), 6.64 (s broad, IH), 2.82 (m, 4H), 2.45 (m, IH), 1.35-1.90 (m, 16H) Stage 4: N-(4-Cyclohexyl-phenyl)-N-(2-piperidin-l-yl-phenyl)-hydrazine (i) The product {8 0 rag) is obtained according to the method of stage 4 of Example 1, by using 200 mg of the preceding derivative as starting product and 240 mg of sodium nitrite in 3 mL of acetic acid leading to the nitroso intermediate which is reduced by 181 mg of lithium hydride and aluminium (8 equivalents) in 3 rnL of tetrahydrofurane in reflux. Yield: 38% 'H NMR {CDCI3, 3 00 MHz) 5 {ppm): 6.75-7.2 5 (bulk aromatic, 8H) , 4.75 (s broad) , 2.97 (m, 4H), 2.42 (m, IH), 1.25-1.90 (bulk aliphatic, 16H) MS: MH" 35 0 Stage 5: methyl 5-hroino-4- [N- (4-cyclohexyl-phenyX) -N-(2-piperidin-l-yl-phenyl) -hydrazine carbonylmethyX] -2-methoxy-benzoate The product is obtained according to the metho^l of stage 3 in Example 6, by using 70 mg of the previous hydrazine and 6 7 mg of the acid of the preparation 2 in the presence of 42 mg of EDCI and 30 mg of HOBt in 3 mL of dimethylformamide. With a purification by reversed phase chromatography (conditions : CI 8 column, 21.2x150 mm, isecratio mode 50% acetonitrile/H^O + 0.05% TFA, flow rate : 15 mL/min, wavelengths : 220 and 254 nm) 32 mg of the expected product were able to be isolated as a TFA salt. Yield: 21% HPLC: 93% MS: MH"" 63 4/636 Stage 6: 5-bromo-4~IN-(4-eyelohexyl-phenyl)-N- (2-piperidin-1-yl-phenyl)-hydrazinocarbonylmethyl]-2-methoxy-benzoic acid hydrochloride (9) The product (22 mg) is obtained as a hydrochlc)ride according to the method of stage 6 of Example 2, by using as a substrate the obtained product from the previous stage. Yield: 68% MP: 163-181°C Elementary analysis calculated for C33H3eBrN3O4.1HC1.0.75H2O: C, 59.11; H, 6.09; N, 6. 27. Found: C, 59.23; H, 6.25; N, 6.03. HPLC: 93% MS: MH" 620/622 Example 10: 5-broino-2-niethoxy-4- [N- (2-methyl-6-piperidin-1-yl-phenyl)-N-{4-trifluoromethoxy-phenyl)-hydrazinocarbonylniethyl] -benzoic acid hydrochloride (10) Stage 1: (2-r.c'thyl-6-nitro-phenyl) - (4-trifluoroinethoxy-phenyl)-amine The product (1.95 g) is obtained as a hydrochloride according to the method of stage 1 of Example 4, by using 1 g of 2-f luoro-3-methyl-nitrobenzene and 1.3 mL of 4-trifluoromethoxy-aniline in the presence of 1.16 g of potassium tert-butanolate in 10 mL of DMSO. Yield: 95% ^H NMR (CDCI3, 5 00 MHz) 6 (ppm) : 8.19 {s broad), 7.97 (d, IH), 7.45 (d, IH), 7.10 (m, 3H), 6.74 (d, 2H), 2. 11 (s, 3H) HPLC: 75% MS; MH"" 313 Stage 2: 3-methyl-N^- (4-trifluoromethoxy-phenyl) - henzene-1, 2-diamitie The product (901. mg) is obtained according to the method of stage 2 of Example 1, by using 1.92 g of the preceding derivative as a starting product and 6. 94 g of tin chloride hydrate in 25 mL of ethanol. Yield: 52% 'H NMR (CDCI3, 300 MHz) 6 (ppm): 7.07 (ra, 3H), 6.73 (m, 2H} , 6.53 (d, 2H) , 5.10 (s broad, IH) , 3.99 (s broad, 2H), 2.18 (s, 3H) HPLC: 90% MS: MH' 2 83 Stage 3: (2-methyl-6-piperidin-l-yl-phenyl) - (4-trifluoroiaethoxy-phenyl) -amine The product {890 mg) is obtained according to the method of stage 3 in Example 4, by using 900 mg of the preceding derivative as starting product, 433 tiL of dibromopentane and 1.3 mL of DIPEA in 15 mL of toluene. Yield: 79% ^H NMR (CDCI3, 300 MHz) 6 (ppm): 7.04 (m, 3H), 6.95 {d, 2H) , 6.66 (d, 2H) , 6.19 (s broad, IH)-,- 2 .72 (ra, 4H) , 2.11 (s, 3H), 1.56 {m, 6H) HPLC: 96% MS: MH* 351 Stage 4 : N~ (2-methyl-6-piperidin-l-yl-phenyl) -N- f4-trifluoromethoxy-phenyl)-hydrazine (j) The product (270 mg) - contaminated by the starting amine - is obtained according to stage 4 of Example 1, by using 450 mg of the preceding derivative as a starting product and 514 mg of sodium nitrite in 4 mL of acetic acid leading to the nitroso intermediate which is reduced by 355 mg of lithium aluminium hydride (8 equivalents) in 4 mL of tetrahydrofurane with reflux. Estimated yield: 23% MS: MH"" 365 Stage 5: methyl 5-bromo-2-methoxy-4- [N- (2-methyl-6-piperidin-1-yl-phenyl)-W- (4-trifluoromethoxy-phenyl}-hydraz inocarbonylmethyl]-benzoate The product is obtained according to the method of stage 3 of Example 5, by using 400 mg of the preceding hydrazine and 365 mg of the acid of preparation 2 in the presence of 231 mg of EDCI and 153 mg of HOBt in 4 mL of dimethylf ormamide. With purification by-reversed phase chromatography (conditions: C18 column, 21.2x150 mm, isocratic mode 35% acetonitrile/H20 + 0.05% TFA, flow rate : 15mL/min, wavelengths : 220 and 254 nm) it was possible to isolate 260 mg of the expected product &s a TFA salt. Yield: 36% ^H NMR (CDCI3, 300 MHz) b (ppm) : 12,26 (s broad, IH) , 11,42 (s, IH) , 7.94 (s, IH) , 7.50 (m, 3H> , 7.09 (m, 3H), 6.62 (d, 2H), 4.02 (m, 2H), 3.87 (s, 6H), 3.60 (m, 1H>, 3.31 (m, 2H), 3.15 (m, IH), 2.24 {s, 3H>, 2.14 (m, 1H>, 1.79-1.94 (m; 4H), 1.52 (m, IH) HPLC: 95% MS: MH" 650/652 Stage 6: 5-bromo^2-iaethoxy--4~ [N- (2-inethyl-6-piperidin-1-yl-phenyl) -N- (4^trifluoromethoxy-phenyl) -hydrazino-carbonylmethyl]-benzoic acid hydrochloride (10) The product (166 mg) is obtained as a hydrochloride according to the method of stage 6 of Example 2, by using as a substrate the product obtained in the previous stage. Yield: 62% MP: 128 "C (decomposition) Elementary analysis calculated for C29H2sBrF3N3O5.lHCl.lH2O: C, 50.41; H, 4.67; N, 6.08. Found: C, 50.02; H, 4.68; N, 5.82. HPLC: 96% MS: MH" 636/638 Example 11: 5-broino-2-inethoxy-4- [N- (4 ' -methoxy-biphenyl-4-yl}-N-(2-piperidin-l-yl-phenyl}-hydrazino-carbonylmethyl]-benzoic acid hydrochloride til) Stage 1: {4~bromo^phenyl)~ (2-nitro-phenyl)-amine The product (6.49 g} is obtained according to the method of stage 1 of Example 4, by using 3.73 mL of 2- fluoro-nitrobenzene and 7.31 g of 4-bromoaniline in the presence of 6.36 g of potassium tert-butanolate in 120 mL of DMSO. Yield: 62% ^H NMR (CDCI3, 300 MHz} 5 (ppm) : 9.38 (s broad, 1H> , 8.19 (d, IH), 7.51 (d, 2H), 7.38 (t, IH), 7.17 (t, 3H), 6.81 (t, IH) HPLC: 99% MS: MH' 293/295 Stage 2: N~ (4-bromo-phenyl)-henzene-1,2-diamine The product (571 mg) is obtained according to the method of stage 2 of Example 1, by using 723 mg o£ the previous derivative as a starting product and 2.78 g of tin chloride hydrate in 7 mL of ethanol. Yield: 88% ^H NMR {CDCI3, 300 MHz) 6 (ppm): 7.26 (d, 2H), 7.05 (m, 2H}, 6.78 (m, 2H), 6.6 0 (d, IH) HPLC: 97% MS: MH" 263/265 Stage 3: (4-bromo-phenyl}- (2-piperidin-1-yl-phenyl)-amine The product (1.03 g) is obtained according to the method of stage 3 of Example 4, by using 1.35 g of the previous derivative as a starting product, 698 pL of dibromopentane and 2.1 mL of DIPEA in 13 mL of toluene. Yield: 61% 'H NMR (CDCl,, 300 MHz) 5 (ppm): 7.36 {m, 2H) , 7.26 (m, IH) , 7.01-7.10 (m, 4H} , 6.89 (m, IH) , 6.56 (s broad, IH) , 2.82 (t, 4H) , 1,5 7-1.74 (m, 6H) HPLC: 100% MS: MH" 331/33 stage 4: (4 • -methoxy-biphenyl~4-yl) - (2-piperidin~l-yl-phenyl) -amine To a solution of 554 mg of the brominated derivative obtained previously in 14 rtiL of a 50:50 methanol/toluene itiixture are successively added 380 mg of phenylboronic acid (1.5 equivalents), 96 mg of palladium tetrakis (0.05 equivalents), 212 mg of lithium chloride (3 equivalents) and 4.17 mL of a 1 molar solution of calcium carbonate. The whole is refluxed for 2 hrs. The reaction crude product is extracted with ethyl acetate several times; the collected organic phases are washed with water, and then dried on magnesium sulfate, filtered and evaporated under ^reduced pressure. The obtained residue is purified by silica gel chromatography (petroleum ether and then petroleum ether/ethyl acetate: 99/1) leading to 260 mg of the expected product. Yield: 43% 'H NMR {CDCl.i, 300 MHz) 6 fppm) : 7.53 (m, 4H) , 7.38 [dd, IH) , 7.2 5 (ifl, 2H) , 7.12 (dd, IH) , 6.97-7.10 (m, 3H) , 6.88 (td, Iti) , 6.76 {s broad, 1H> , 3,86 (s, 3H) , 2.87 (t, 4H), 1.52-1-78 (m, 6H) HPLC: 8 0% MS: MH" 359 Stage 5: N- (4 • -methoxy-hiphenyl-4-yl) -N- (2-piperidin-l-yl -phenyl}-hydrazine (k) The product (141 rng) is obtained according to the method of stage 4 of Example 1, by using 203 mg of the previous derivative as a starting product and 226 mg of sodium nitrite ii^ 1-5 ™i= of acetic acid leading to the nitroso intermediate which is reduced by 179 mg of lithium aluminium hydride (8 equivalents) in 4 mL of tetrahydrofurane ^'ith reflux. Yield: 64% ^H NMR (CDCI3, 300 MHz) 6 (ppm): 7.49 (d, 2H), 7.38 (d, 2H), 7.14 (m, 2H), 6.93 (m, 4H), 6.87 (d, 2H), 3.84 (s, 3H), 2.92 (m, 4H); 1.39 (m, 6H) HPLC: 90% MS: MH^ 374 Stage 6: methyl 5^t>romo-2-methoxy-4- [N- (4 '-methoxy-biphenyl~4-yl) -N- (2-piperidin-l-yl-phenyl) -hydrazine-carbonylmethyl]-b&nzoate The product is (Obtained according to the method of stage 3 of Example 6, by using 141 mg of the previous hydrazine and 126 mg of the acid of preparation 2 in the presence of 79 mg of EDCI and 56 mg of HOBt in 6 mL of dimethylformamide. With a purification by reversed phase chromato^i"aphy (conditions CI 8 column, 21.2x150 mm, isocratic mode 50% acetonitrile/H20 + 0.05% TFA, flow irate: 15 mL/min, wavelengths: 220 and 254 nm) , 9 mg of the expected product were able to be isolated as a TFA salt. Yield (non-optimised) : 3% HPLC: 75% MS: MH" 658/660 Stage 7: 5-broiao-2-ifiethoxy-4- [N- (4 ' -inethoxy-biphenyl-4-yl) _J7_ (2-piperidifl-l-yl-phenyl} -hydrazino-carbonyl-methyl] -benzoic ac:id hydrochloride (11) The product (7.3 mg) is obtained as a hydrochloride according to the method of stage 6 or Example 2, by using as a substrate the product obtained in the previous stage . Yield; 92% HPLC: 80% MS: MH" 644/646 Example 12 : 5-broino-4- [N- (4-cyclohexyloxy-phenyl) -N- (2-piperidin-1-yl-ph^nyl)-hydrazino-carbonylmethyl]-2-methoxy-benzoic ac^id hydrochloride (12) Stage 1: l-cyclohexyloxy-4-nitro-benzene To 3.9 g of cycloliexanol (1.1 equivalents) put into the presence of 2.12 g of sodium hydride (1.5 equivalents) under stirring for 10 min, is added a solution of 5 g of 4-fluoronitrobenzene in 7 5 mL of dimethylformamide. The whole is heated t--60°C for 5 hrs. After returning to room temperatui^e, the medium is hydrolyzed and the reaction crude product is extracted with ethyl acetate several times. The organic phases are dried on magnesium sulfate, filtered and evaporated under reduced pressure. With a silica gel chromatography of the residue (cyclohexane and then cyclohexane/ethyl acetate: 98/2 and 90/10) 6.06 g of the desired product are able to be isfplated. Yield: 78% ^H NMR {CDCI3, 300 MHz) 6 (ppm): 8.16 (d, 2H), 6.92 (d, 2H) , 4.37 (m, IH) , 1-98 (m, 2H) , 1.81 (m, 2H) , 1.3 5-1.65 (m, 6H) HPLC: 98% MS: [M+Na]" 244 Stage 2: 4-cycloh&xyloxy-phenylamine The product (4.48 g) is obtained according to the method of stage 2 of Example 5, by using 6.06 g of the previous derivative as a starting product and 30.9 g of tin chloride hydrate in 59 mL of ethanol. Yield: 87% ^H NMR (CDCli, 300 MH2) 5 (ppm): 6.76 (d, 2H), 6.62 (d, 2H) , 4.06 (m, IH) , 3.42 (s broad, 2H) , 1.95 (m, 2H) , 1.78 (m, 2H), 1.28-1.60 (m, 6H) HPLC: 88% MS: MH* 192 Stage 3: (4-cyclohexyloxy-phenyl)-(2-nitro-phenyl)~ amine The product (4.27 g) is obtained according to the method of stage 1 of Example 4, by using 2.95 mL of 2- fluoro-nitrobenzene and 4.48 g of the product obtained in the previous stage in the presence of 4.18 g of potassium tert-butanolate in 108 mL of DMSO. Yield: 59% ^H NMR (CDCI3, 300 MHz) 5 (ppm) : 9.40 (s broad, IH) , 8.20 (d, IH), 7.35 {m, 1H>, 7.18 (m, 2H>, 6.95-7.05 (m, 3H), 6.72 (m, IH), 4.06 (m, IH), 2.05 (m, 2H), 1.82 (m, 2H), 1.35-1.60 (m, 6H) HPLC: 86% MS: MH" 313 Stage 4: N-(4-cyclohexyloxy-phenyl)-benzene-1,2-diamine The product (3.43 g) is obtained according to the method of stage 2 of Example 1, by using 4.27 g of the previous derivative as a starting product and 15.42 g of tin chloride hydrate in 27 mL of ethanol. Yield: 88% 'H NMR (CDCI3, 300 MHz) b (ppm): 7.04 (d, IH), 6.94 (m, IH), 6.72-6.84 (m, 6H), 4.14 (m, IH), 1.97 (m, 2H), 1.80 {m, 2H), 1.3 0-1.60 (m, 6H) HPLC: 92% MS: MH"" 283 Stage 5: (4-cyclohexyloxy-phenyl) ~ (2-piperidin-l-yl-phenyl)-amine The product (1.55 g) is obtained according to the method of stage 3 of Example 4, by using 3.43 g of the previous derivative as a starting product, 1.65 mL of dibromopentane and 5.1 mL of DIPEA in 49 ml of toluene. Yield: 36% ^H NMR (CDCI3, 300 MHz) 6 fppm} : 7.07 (m, 4H) , 6.80-6 .98 (m, 3H> , 6.78 (m, IH) , 5.52 (s broad, IH) , 4.21 (m, IH), 2.86 (m, 4H), 1.3 5-2.05 (m, 15H) HPLC: 99% MS: MH^ 351 Stage 6: N- {4-cyclohexyloxy-pbenyl) -N- (2-pipBridi-n-l-yl-phenyl) -hydrazine (I) The product (118 rag) is obtained according to the method of stage 4 of Example 1, by using 5 00 mg of the previous derivative as a starting product and 571 mg of sodium nitrite in 4 raL of acetic acid leading to the nitroso intermediate which is reduced by 431 mg of lithium aluminium hydride (8 equivalents) in 4 mL of tetrahydrofurane with reflux. Yield: 23% 'H NMR (CDCI2, 300 MHz) 6 (ppm) : 7.00-7 .18 (m, 5H) , 6.94 (m, IH),6.90 {m, 2H), 4.7 7 (s broad, IH), 4.09 (m, IH) , 2.98 (m, 4H) , 2.00 (m, 2H) , 1.80 (m, 2H) , 1.24-1.67 (m, 12H) HPLC: 94% MS: MH' 366 Stage 7: methyl 5-bromo-4~ [N- (4-cyclohexyloxy~phenyl) ~ N- (2-piperidin.-l-yl-phenyl) -hydrazinocarbonylmethyl] -2-methoxy-henzoate The product is obtained according to the method of stage 3 of Example 6, by using 50 mg of the previous hydrazine and 46 mg of the acid of preparation 2 in the presence of 29 mg of EDCI and 20 mg of HOBt in 1.5 mL of dimethylformamide. With a purification by reversed phase chromatography of a fraction [conditions; C18 column, 21.2x150 mm, isocratic mode 45% acetonitrile/H20 + 0.05% TFA, flow rate: 15 mL/min, wavelengths: 220 and 254 nm) 57 mg of the expected product were able to be isolated as a TFA salt. Estimated yield: 54% HPLC: 92% MS: MH"" 650/652 Stage 8: 5-bromo-4-[N-(4-cyclohexyloxy-phenyl)-N-(2-piperidin-l-yl-phenyl)-hydrazinocarbonylmethyl]-2-methoxy-benzoic acid hydrochloride (12) The product {61 mg) is obtained as a hydrochloride according to the method of stage 6 of Example 2, by using as a substrate the product obtained in the previous stage. Yield: 85% MP: 145-180 "c HPLC: 91% MS: MH^ 636/638 Example 13: 5-bromo-2-methoxy-4-[N-{4-phenoxy-phenyl}- N-(2-piperidin-l-yl-phenyl)-hydrazinocarbonyl-methyl]- benzoic acid hydrochloride (13) Stage 1: (2-nitro-phenyl)-(4-phenoxy-phenyl)-amine The product (2.03 g) is obtained according to the method of stage 1 of Example 4, by using 3.7 mL of 2- fluoro-nitrobenzene and 7.88 g of 4-phenoxyaniline in the presence of 6.35 g of potassium tert-butanolate in 34 mL of DMSO. Yield: 18% "■H NMR {CDCI3, 300 MHz) 6 (ppm) : 9.44 (s broad, IH) , 8.20 (d, IH), 7.37 {m, 3H), 7.25 (m, 2H), 7.05-7.IS (m, 6H), 6.76 (m, IH) HPLC: 80% MS: MH"* 3 07 stage 2: N~ (4-phenoxy-phenyl)-benzene-1,2-diamine The product (70 9 mg) is obtained by catalytic hydrogenation in the presence of 2 03 mg of io% palladium on charcoal in 40 mL of ethanol. Yield: 38% ■^H NMR [CDCI3, 300 MHz) b (ppm) : 7.30 {m, 2H) , 5.90- 7.12 (m, 7H), 6.70-6.85 (m,4H) HPLC: 100% MS: MH" 277 Stage 3: (4-phenoxy-phenyl)-{2-piperidin-l-yl-phenyl)-amine The product (799 mg) is obtained according to the method of stage 3 of Example 4, by using 7 09 mg of the previous derivative as a starting product, 350 JAL of dibromopent ane and 1.07 mL of DIPEA in 10 ml, of toluene. Yield: 82% 'H mm {DMSO. 300 MHZ) d (pptn) : 7.40 (d, IH) , 7.25 (m, 4H), 7.03 (m, 4H), 6.95(m, 4H), 3.37 (m, 4H), 1.9C) (m, 4H), 1.61 (m, 2H) HPLC: 100% MS: MH* 34 5 Stage 4: N-(4-phenoxy-phenyl)-N- (2-piperidin-l-yl-phenyl) -hydrazine (m) The product (185 mg) is obtained according to the method of stage 4 of Example 1, by using 400 mg of the previous derivative as a starting product and 420 Tag of sodium nitrite in 3 mL of acetic acid leading tQ the nitroso intermediate which is reduced by 319 mg of 1 ithium aluminium hydride (8 equivalents) in 3 rriL of tetrahydrofurane with reflux. Yield: 49% ^H NMR (CDC13, 300 MHz) 5 (ppm) : 6.92-7.26 (m, :L3H), 4.82 (s broad, 2H), 2.97 (m,4H), 1.55-1.69 {2m, 6H) HPLC: 97% MS: MH"" 360 Stage 5: methyl 5-bromo-2-inethoxy-4- [N- (4-phenoxy-phenyl) -N- (2-piperidin-l-yl-phenyl) -hydrazinocarbofiyl-methyl]-benzoate The product {270 mg} is obtained according to the method of stage 3 of Example 6, by using 185 mg of- the previous hydrazine and 172 mg of the acid of the preparation 2 in the presence of 108 mg of EDCI and 76 rag of HOBt in 3 mL of diraethylformamide. Yield: 81% ^H NMR (CDCI3, 300 MHz) 6 (ppm): 9.35 (s broad, IH} , 7.97 (d, IH), 6.75-7.5 0 (bulk aromatic, 14H}, 3.70-3.94 (3s, 8H), 2.68 (m, 4H), 1.46-1.59 (m, 6H) HPLC: 77% MS; MH" 644/646 Stage 6: 5-broino-2-methoxy-4- [N- {4-phenoxy-pheny}-) -W'-(2-piperidin- 1-yl-phenyl) -hydrazinocarbonylmethyl] -benzoic acid hydrochloride (13) The product is obtained according to the method of stage 5 of Example 2 , by using as a substrate the product obtained in the previous stage. With purification by reversed phase chromatography of a fraction [conditions: CIS column, 21.2x150 mm, isocratic mode 35% acetonitrile/HaO + 0.05% TFA, flow rate : 15 mL/min, wavelengths : 220 and 254 nm} followed by a treatment with a 1 N hydrochloric acid solution, the expected product was able to be isolated as a hydrochloride (89 rag). Yield: 32% MP: 232-235 °C Elementary analysis calculated for C3jH32BrN^05.lHCl.lH20: C, 57.86; H, 5.15; N, 6-13. Found: C, 57.74; H, 5.01; K, 5.89. HPLC: 97% MS: MH" 630/632 Example 14 : 5-bromo-4-{N- [4- {4-chloro-phenoxy) -pheriyll - N~ {2-piperidin-1-yl-phenyl)-hydrazinocarbonylmethyl}-2- methoxy-benzoic acid hydrochloride {14} Stage 1: [4-(4-chloro-phenoxy)-phenyl]-(2-nitro- phenyl)-amine The product {609 mg) is obtained according to the method of stage 1 of Example 4, by using 84 0 yL of 2- f luoro-nitrobenzene and 2.1 g of 4-(chlorophenc'^y)- aniline in the presence of 1.43 g of potassium t-ert- butanolate in 20 mL of DMSO. Yield: 22% 'H NMR (CDCI3, 3 00 MHz) 5 (ppm> : 8.21 (d, IH) , 7-24- 7.4 0 (m, 5H), 6.97-7.14 (m, 5H), 6.77 (t, IH) HPLC: 97% MS: MH"" 341/343 Stage 2: N- [4-(4-chloro-phenoxy}-phenyl]-benzene^l^2-diamine The product {524 mg> is obtained according to the method of stage 2 of Example 1, by using 609 mg o£ the previous derivative as a starting product and 2 g of tin chloride hydrate in 10 mL of ethanol. Yield: 94% ^H NMR (CDCI3, 300 MHz) 5 (ppm) : 6.73-7.38 (bulk aromatic, 12H) HPLC: 100% MS: MH* 311/313 stage 3: [4-(4-Chloro-phenoxy)-phenyl]-{2-piperidin-l-yl-phenyl)-amine The product (596 mg) is obtained according to the method of stage 3 of Example 4, by using 684 mg of the previous derivative as a starting product, 300 laL of dibromopentane and 920 pL of DIPEA in 15 mL of toluene. Yield: 71% ^H NMR (CDCl-,, 300 MHz) 5 (ppm) : 6.80-7.2 8 (bulk aromatic, 12H) , 6.66 [s broad, IH) , 2.86 (m, 4H) , 1,72 (m, 4H), 1.61 (m, 2H) HPLC: 99% MS: MH*" 379/381 Stage 4 : N- [4- (4-chloro~phenoxy) -phenyl] -N- (2-piperidin-1-yl-phenyl)-hydrazine (n) The product (80 mg) is obtained according to the method of stage 4 of Example 1, by using 300 mg of the previous derivative as a starting product and 317 mg of sodium nitrite in 3 mL of acetic acid leading to the nitroso intermediate which is reduced by 12 0 mg of lithium aluminium hydride (4 equivalents) in 5 mL of tetrahydrofurane. Yield: 26% ^H NMR (CDCli, 300 MHz} 5 (ppm): 6.86-7.25 (bulk aromatic, 12H) , 2 . 98 {m, 4H) , 1.7 0 (m, 4H) , 1.56 (m, 2H) HPLC: 83% MS: MH* 394/396 Stage 5: methyl 5~broino-4-{N- [4- (4-chloro~phenoxy) -phenyl] -N- (2-piperidin-l-yl-phenyl) -hydrazinocarbonyl-me thyl}-2-me thoxy-benzoa. te The product (8 6 mg) is obtained according to the method of stage 3 of Example 6, by using 80 mg of the previous hydrazine and 68 mg of the acid of preparation 2 in the presence of 43 mg of EDCI and 30 mg of HOBt in 3 niL of dimethylformamide. Yield: 62% 'H WMR {CDCI3, 300 MHz) 5 (ppm) : 9.35 (s broad, IH) , 7.97 (d, 1H>, 6.75-7.52 {bulk aromatic, 13H), 3.67-3.91 (3s, 8B), 2.68 (m, 4H), 1.42-1.59 (m, 6H) HPLC: 94% MS: MH"' 678/68 0 Stage 6: 5-broino-4-{N- [4- (4-chloro-phenoxy) -phenyl] -N-(2-piperid7n-l-yl-phenyl) -hydrazino-carhonylmethyl}-2-methoxy-henzoic acid hydrochloride (14) The pifoduct (52 mg) is obtained as a hydrochlijride according to the method of stage 6 of Example 2, by using as a substrate the product obtained in the previous stage. Yield: 62% MP: 153.5-163.5°C HPLC: 95% MS: MH* 664/666 Example 15: 4-{N-[4-(4-fluoro-phenoxy)-phenyl]-N-(3-methyl'6-piperidin-l-yl-phenyl)-hydrazinocarbonyl-inethyl)-2-inethoxy-benzoic acid hydrochloride {15) Stage 1: [4- (4-fluoro-phenoxy) -phenyl] - (2-methyl-6^ nitro-phenyl)-amine The product (790 mg) is obtained according to the method of stage 1 of Example 4, by using 90 0 yL of 2-f luoro-S-methyl-nitrobenzene and 2.6 g of 4- (4 -f luioro-phenoxy)-phenylamine obtained in stage 2 of Example 5 in the presence of 2.36 g of potassium tert-butanc?late in 80 rnL of DMSO. Yield: 40% ^H NMR (CDClj, 300 MHz) 6 {ppm): 8.38 (s broad, IH} , 1.98 (d, IH), 7.40 (d, IH), 6.87-7.06 (bulk aromatic, 7H), 6.V6 (d, 2H), 2.08 (s, 3H) HPLC: 84% MS: MH" 33 9 Stage 2: if- [4- (4-fluoro-phenoxy) -phenyl] -3-me thy 1- henzene-1, 2-diamLne The product {1.58 g) is obtained by hydrogenation according to the method of stage 2 of Example 13. Yield: 87% ^H NMR (CDCl.i, 300 MHz) 6 (ppm) : 6.83-7.01 (bulk aromatic, 7H) , 6.67 [d, 2H) , 6.55 (d, 2H> , 4.92 (s broad, IH) , 3.8 9 (s broad, 2H) , 2.1R..(s, 3H) HPLC: 98% MS: MH' 309 Stage 3: [4-(4-fluoro-phenoxy)-phenyl]-(2-methyl-6~ piperldin-l-yl-phsnyl)-amine The product (1.16 g) is obtained according to the method of stage 3 of Example 4, by using 1.58 g of the previous derivative as a starting product, 700 uL of dibromopentane and 2.14 mh of DIPEA in 3 0 mL of toluene. Yield: 60% ^H NMR (CDCI3, 300 MHz} 6 (ppm): 6.84-7.01 (bulk aromatic, 9H) , 6.70 (d, 2H) , 6.18 (s broad, IH) , 2.74 (m, 4H), 2.13 (s, 3H), 1.5 8 (m, 6H) HPLC: 98% MS: MH' 377 Stage 4 : N- [4- (4-fluoro-phenoxy) -phenyl] -N- (2-methyl-6-piperidin-1-yl-phenyl)-hydrazine (o) The product (198 mg) is obtained according to the method of stage 4 of Example 1, by using 525 mg of the previous derivative as a starting product and 558 mg of sodium nitrite in 4 mL of acetic acid leading to the nitroso intermediate which is reduced by 2 08 mg of lithium aluminium hydride (4 equivalents) in 4 mL of tetrahydrofurane. Yield: 36% ^H NMR (CDCI3, 3 00 MHz) 6 (ppm): 6.83-7.18 (bulk aromatic, HH) , 4.87 (s broad, 2H) , 2.68 and 2.94 (4H, 2m), 2.12 (s, 3H), 1.50-1.64 (m, 6H} HPLC: 76% MS: MH"" 3 92 Stage 5: methyl 4-{N- [4- (4~fluoro-phenoxy) -phenyl] -N-(2-inethyl-6-piperidin-l-yl-phenyl) -hydrazinocarbonyl-methyl}-2-niethoxy^benzoate The product (141 mg) is obtained according to the method of stage 3 of Example 6, by using 95 mg of the previous hydrazine and 60 mg of the acid of the preparation 1 in the presence of 51 mg of EDCI and 36 mg of HOBt in 1.5 mL of dimethylf orniamide. Yield: 97% ^H NMR (CDCI3, 300 MHz) 5 (ppm): 9.76 (s broad, IH) , 7.74 (d, IH) , 6.5O-7.22 (bulk aromatic, 13H) , 3.87 [s, 3H), 3.70 [m, 5H), 2.72 (m, 2H), 2.44 (s, 3H), 2.30 (m, 2H) , 1.30-1.42 {2tn, 6H) HPLC: 97% MS: MH*" 5 98 Stage 6: 4-{N- [4-(4-fluoro-phenoxy)-phenyl]-N- (2-methyl-6-piperidin-1-yl-phenyl)-hydrazinocarbonyl-methyl}-2-inethoxy~benzoic acid hydrochloride (15) The product (131 mg) is obtained as a hydrochloride according to the method of stage 6 of Example 2, by using as a substrate the product obtained in the previous stage. Yield: 90% MP: 155-168 "C HPLC: 100% MS: MH"* 584 Example 16 : 5-broino-4-{N- [4- (4-f luoro-phenoxy) -phenyl] - K- (2-inethyl-6-piperidin-l-yl-phenyl) -hydrazino- carbonylmethyl}~2^inethoxy-benzoic acid hydrochloride (16} Stage 1: methyl 5~bromo-4-{N-[4-{4-fluoro-phenoxy)- phenyl] ~N- (2-inethyl-6-piperidin-l-yl-phenyl) -hydrazino- carbonyliae thyl}-2~ine thoxy-benzoate (16a) The product {154 mg) is obtained according to the method of staqe 3 of Example 6, by using 95 mg of the hydrazine of stage 4 of Example 15 and 81 mg of the acid of preparation 2 in the presence of 51 mg of EDCl and 36 mg of HOBt in 1.5 mL of dimethylformamide. Yield: 94% ^H NMR [CDCI3, 300 MHz) 6 (ppm) : 9.86 (s broad, IH) , 7.98 (s, 1H> , 6.84-7.23 (bulk aromatic, lOH), 6.57 (d, 2H), 3.87 (s, 3H), 3.76 {s, 2H), 3.71 (s, 3H), 2.80 (m, 2H1, 2.44 (s, 5H>, 1.37-1.48 (2m, 6H> HPLC: 91% MS: MH* 676/678 Stage 2: 5-bromo~4-{N-[4-(4-fluoro-phenoxy)-phenyl]-N-(2-methyl-6-piperidin-l~yl-phenyl)-hydrazinocarbonyl-methyl}-2-methoxybenzoic acid hydrochloride (16) The product (116 mg) is obtained as a hydrochloride according to the method of stage 6 of Example 2, by using as a substrate the product obtained in the previous stage. Yield: 73% MP: 155-168 ^C Elementary analysis calculated for Ci4Hi.iBrFN,05.1HC1.1.5H20: C, 56.25; H, 5.14; N, 5.79. Found: C, 56.31; H, 5.04; N, 5.61. HPLC: 98% MS: MH"" 662/664 Example 17: 4-[N-(4-benzyl-phenyl)-N-(2-piperidin-l-yl-phenyl}-hydrazinocarbonylmethyl]-5-bromo-2-methoxy-benzoic acid hydrochloride (17) Stage 1: (4-benzyl-phenyl)-(2-ni tro-phenyl)-amine The product (621 mg) is obtained according to the method of stage 1 of Example 4, by using 958 uL of 2-fluoro-nitrobenzene and 2 g of 4-benzylaniline in the presence of 1.63 of potassium tert-butanolate in 30 niL of DMSO. Yield: 22% ^H NMR (CDCls, 300 MHz) 6 {ppra) : 9.46 (s broad, IH) , 8.19 (d, IH) , 7.71 (d, IH) , 7.44 (m, IH) , 7.10-7.40 (bulk aromatic, 9H), 6.74 (m, IH), 4.01 (s, 2H) HPLC: 78% MS: [M+Na]^ 327 Stage 2: N- (4-benzyl-phenyl)-benzene-1,2-diamine The product (2 91 mg) is obtained by hydrogenation according to the method of stage 2 of Example 13, Yield: 52% HPLC: 100% MS: MH^ 275 Stage 3: (4-benzyl-phenyl)-(2-piperidin-l-yl-phenyl)-amine The product (213 mg) is obtained according to the method of stage 3 of Example 4, by using 2 91 mg of the previous derivative as a starting product, 144 laL of dibromopentane and 4 44 ]ih of DIPEA in 4 mL of toluene. Yield: 59% 'H NMR (CDClj, 300 MHz) 6 (ppm): 6.79-7.32 (bulk aromatic, 13H) , 6.63 (s broad, IH) , 3.94 (s, 2H) , 2.83 (m, 4H) , 1.70 (m, 4H) , 1.58 (m, 2H) HPLC: 96% MS: MH" 34 3 Stage 4 : N- (4-benzyl-phenyl] -N- (2-piperidin-l-yl-phenyl)-hydrazine (p) The product {60 mg) is obtained according to the method of stage 4 of Example 1, by using 213 mg of the previous derivative as a starting product and 249 mg of sodium nitrite in 3 mL of acetic acid leading to the nitrose intermediate which is reduced by 189 mg of lithium aluminium hydride (8 equivalents) in 3 mL of tetrahydrofurane. Yield: 27% ^H NMR {CDCI3, 300 MHz) b (ppm): 6.92-7.31 (bulk aromatic, 13H) , 4.75 (s broad, IH) , 3.91 {s, 2H) , 2.96 (m, 4H), 1.66 (m, 4H), 1.54 (m, 2H) HPLC: 100% MS: MH" 3 58 Stage 5: methyl 4- [N- (4-benzyl-phenyl) -N- (2-piperidin-l-yl~phenyl) -hydrazinocarbonylmethyl] -S-bromo-S-methoxy-benzoate The product (64 mg) is obtained according to the method of stage 3 of Example 6, by using 60 mg of the previous hydrazine and 56 mg of the acid of preparation 2 in the presence of 35 mg of EDCI and 25 mg of HOBt in 1 mL of dimethylformamide. Yield: 59% ^H NMR (CDCI3, 300 MHz) 6 (ppm) : 9.33 (s broad, IH) , 7.98 (d, 1H> , 6.71-7.51 (bulk aromatic, 14H) , 3.95 (s, 6H) , 3.7 0 and 3.76 (2s, 4H) , 2.74 (m, 4H) , 1.2 8-1.6 0 (m, 6H) HPLC: 90% MS: MH^ 642/644 stage 6: 4- [N- (4-benzyl-phenyl) -N- (2-piperidin-l-yl-phenyl) -hydrazinocarhonylmethyl] -5-bromo-2-iiiethoxy-benzoic acid hydrochloride (17) The product {58 mg) is obtained as a hydrochloride according to the method of stage 6 of Example 2, by using as a substrate the product obtained in the previous stage, Yield: 88% MP: 137.5-162 "c HPLC: 97% MS: MH" 628/630 Example 18: 4- [N- (4-bromo-phenyl)-[W- {2-piperidin-l-yl-phenyl)-hydrazinocarbonylmethyl]-5-Ghloro-2-methoxy-benzoic acid hydrochloride (18) Stage 1: N-(4-bromo-phenyl)-N- (2-plperidin-l-yl-phenyl)-hydrazine (q) The product {3 70 rag) is obtained according to the method of stage 4 of Example 1, by using 5 00 mg of the derivative obtained in stage 3 of Example 11 as a starting product and 604 mg of sodium nitrite in 3 mL of acetic acid leading to the nitreso intermediate which is reduced by 45 8 mg of lithium aluminium hydride (8 equivalents) in 3 mL of tetrahydrofurane. Yield: 71% ^H NMR (CDCI3, 300 MHz) 5 (ppm)i 6.98-7.25 {bulk aromatic, 8H) , 4.77 (s broad, 2H) , 2.92 {m, 4H) , 1.66 (m, 4H), 1.55 (m, 2H) HPLC: 88% MS: MH* 346/348 Stage 2: methyl 4-[N- (4~bromo-phenyl) -N- (2-piperidin-l-yl-phenyl) -hydrazinocarbonylmethyl]-5-chloro-2-methoxy-benzoate The product (64 mg) is obtained according to the method of stage 3 of Example 6, by using 370 mg of the previous hydrazine and 304 mg of the acid of preparation 3 in the presence of 225 mg of EDCI and 159 mg of HOBt in 5 mL of dimethylformamide. Yield: 89% ^H NMR (CDCI3, 300 MHz) 6 (ppm) : 9.34 (s broad, IH) , 7.78 {d, IH} , 6 .63-7.49(bulk aromatic, 9H) , 3.87 (2s, 6H), 3.70 (s, 2H}, 2.75 (m, 4H), 1.28 et 1.60 (2m,6H) HPLC: 96% MS: MH' 585/588 Stage 3 : 4- [N- (4-bromo-phenyl) -N- (2-piperidin-l-yl-phenyl)-hydrazinocarbonylmethyl]-5-chloro~2-methoxy-benzoic acid hydrochloride (18) The product (39 mg) is obtained as a hydrochloride according to the method of stage 6 of Example 2, by using as a substrate the product obtained in the previous stage. Yield: 75% MP: 177.2-189 "c HPLC: 95% MS: MM"" 572/574 Example 19: 4-[N-(3'-acetyl-biphenyl-4-yl)-N-(2- piperidin-1-yl-phenyl)-hydrazinocarbonylmethyl]-5- Ghloro-2-methoxy-benzoic acid hydrochloride (19) Stage 1: methyl 4- [N-(3 '-Acetyl-biphenyl~4--yl)-N-(2- piperidin-1-yl-phenyl)-hydrazinocarbonylmethyl]-5- chIoro-2-inethoxy-i)enzoate To a solution of 200 mg of the brominated derivative obtained in stage 2 of Example 18 in 2 mL of a 50:50 methanol/toluene mixture are successively added 84 mg of 3-acetylphenylboronic acid (1.5 equivalents), 20 mg of palladium tetrakis (0.05 equivalents) and 85 i_iL of 1 molar solution of sodium carbonate. The whole is refluxed for 3 hrs, The reaction crude product taken up in water is extracted with ethyl acetate several time, the collected organic phases are washed with a 1 molar solution of soda, and then dried on magnesium sulfate, filtered and evaporated under reduced pressure. The obtained residue is purified by silica gel chromatography (petroleum ether/ethyl acetate: 90/10 and then 80/20 right up to 50/50) leading to 110 mg of the expected product, yield: 51% ^H NMR fCDClj, 300 MHz) b (ppm): 9.35 (s, IH), 8.04 (d, IH), 7.74 (m, 3H), 6.94- 7.62 (bulk aromatic, 8H), 6.80 (m, 2H) , 2.79-3.62 {3s, 8H) , 2.56 (m, 4H) , 2.05 (s, 3H) , 1 .18-1.53 {m, 6H) HPLC: 92% MS: MH" 626/628 Stage 2: 4- [N- (3'-acetyl-biphenyl-4-yl}-N- (2-plperidin-1-yl-phenyl) -hydrazinocarbonylmethy 1] -5-chlorO'-2-methoxy-benzoic acid hydrochloride (19) The product (69 mg) is obtained as a hydrochloride according to the method of stage 6 of Example 2, by using as a substrate the product obtained in the previous stage. Yield: 66% MP: 140.2-165.3°C HPLC: 91% MS; MH' 612/614 Example 20: 4-[N-(4'-acetyl-biphenyl-4-yl)-N-(2-piperidin-1-yl-phenyl)-hydrazinocarbonylmethyl]-5-chloro-2-methoxy-benzoic acid hydrochloride (20} stage 1; methyl 4-[N-(4 '-Acetyl-biphenyl-4-yl}-N-(2-piperidin~l-yl-phenyl) -hydrazinocarhonyltnethyl] -5-chloro-2-methoxy-benzoate The product (167 mg) is obtained according to the method of stage 1 of Example 19, by using as a substrate the product obtained in stage 2 of Example 18 and as a co-substrate 4-acetylphenylboronic acid. Yield: 78% ^H WMR (CDCI3, 300 MHz) 6 (ppm) : 9.35 (s, IH) , 6.70- 7.91 (bulk aromatic, 14H), 3.61-3.78 (3s, 8H), 2.60 (m, 4H), 2.28 (s, 3H), 1.2 0 -T.51 (m, 6H) HPLC: 87% MS: MH"" 62 6/62 8 Stage 2: 4- [N- (4 ' -'acetyl-biphenyl-4-yl} -N- (2-piperidin-1-yl-phenyl)-hydrazinocarbonylmethyl]~5~chloro~2-methoxy-b&nzoic acid hydrochloride (20) The product (82 mg) is obtained as a hydrochloride according to the method of stage 6 of Example 2, by using as a substrate the product obtained in the previous stage. Yield: 47% MP: 165.3-190.l"C HPLC: 100% MS: MH^ 612/614 Example 21: 5-bromo-2-methoxy-4-[N-(3-phenoxy-phenyl)-N- (2-piperidin-l-yi-pheiiyl) -hydrazinocarbonylmethyl] -benzoic acid hydrochloride (21) Stag-e I; (2-nitro-phenyl) - (3-phenoxy-phenyl) -amine The product (2.08 g) is obtained according to the method of stage 1 of Example 4, by using 1.23 mL of 2-fluoronitrobenzene and 3.3 g of 3-phenoxyaniline in the presence of 2.13 g of potassium tert-butanolate in 10 mL of DMSO. Yield: 57% 'H WMR (CDCl^, 300 MHz) 6 (ppm) : 9.38 (s broad, IH) , 8.12 {d, IH), 7.63 (d, IH), 6.7 0-7.43 (m, IIH) HPLC: 79% MS: MH" 307 Stage 2: N- (3-phenoxy-phenyl)-benzene-1,2-diamine The product {1.88 g> is obtained by catalytic hydrogenation in the presence of 210 mg of 10% palladium on charcoal in 4 0 mL of an ethyl acetate/ethanol (1:1) mixture. Yield: quantitative HPLC: 91% MS: MH' 2 77 Stage 3 : (3-Phenoxy-phenyl) - (2-piperidin-l-yl-phenyl) -amine The product (1.22 g) is obtained according to the method of stage 3 of Example 4, by using 1.88 g of the previous derivative as a starting product, 92 5 pL, of dibromopentane and 2.84 niL of DIPEA in 40 mL of toluene. Yield: 52% ^H NMR (CDCl-s, 300 MHz) 6 (ppm): 6.83-7.19 (bulk aromatic, IIH), 6.72(s, IH), 6.53 (dd, IH), 2.81 (m, 4H), 1.50-1.74 {m, 6H) HPLC: 100% MS: MH*^ 34 5 Stage 4 : N- (3-phenoxy-phenyl) -N- (2-piperidin-l-yl-phenyl) -hydrazine (r) The product (99 mg) is obtained according to the method of stage 4 of Example 1, by using 400 mg of the previous derivative as a starting product and 465 mg of sodium nitrite in 3 mL of acetic acid leading to the nitroso intermediate which is reduced by 159 mg of lithium aluminium hydride (4 equivalents) in 4 mL of tetrahydrofurane with reflux. Yield: 24% ^H NMR (CDCI3, 300 MHz) 6 (ppm) : 6.70-7.25 (bulk aromatic, 12H) , 6.28 (dd, IH) , 4.68 {s br-oad, 2H), 2.85 (m, 4H), 1.4 6-1.63 (m, 6H) HPLC: 76% MS: MH' 36 0 Stage 5: methyl 5-bromo-2-methoxy-4- [N- (3-phenoxy-phenyl)-N-(2-piperidin-l~yl-pbenyl}-hydrazinocarhonyl-methyl]-benzoate The product (168 mg) is obtained according to the method of stage 3 of Example 6, by using 99 mg of the previous hydrazine and 92 mg of the acid of preparation 2 in the presence of 5 8 mg of EDCI and 41 mg of HOBt in 1 mL of dimethylformamide. Yield: 95% ^H NMR (CDCI3, 300 MHz) 5 (ppm): 9.35 and 9.40 (2 s broad, IHi , T .96 Us, IH') , 6.41-1.40 (bvilk arom&tic, 14H), 3.70-3.95 (3s, 8H), 2.68 (m, 4H), 1.46-1.59 (m, 6H) HPLC: 96% MS: MH* 644/64 6 Stage 6: 5-bromo-2~methoxy-4-[N-(3-phenoxy-phenyl)-N-(2-piperidin~l-yl-phenyl)-hydraz inocarbonylmethyl]-benzoic acid hydrochloride (21) The product (124 mg) is obtained as a hydrochloride according to the method of stage 6 of Example 2, by using as a substrate the product obtained in the previous stage. Yield: 71% MP: 142-159 "C Elementary analysis calculated for C33H32BrN305. 0 . 75HC1 : C, 60.25; H, 5.02; N, 6.39. Found: C, 59.98; H, 5.11; N, 6.27. HPLC: 96% MS: MH^ 630/632 Example 22: 5-bromo-2-methoxy-4-[N-(4-phenylsulf^nyl-phenyl)-N-(2-piperidin-l-yl-phenyl)-hydrazinocarbonyl-methyl]-benzoic acid hydrochloride {22} Stage 1: 4-phenylsulfanyl-phenylamine To a solution of 5 g of 4-ni-trophenyl sulfure in IQQ mL of an ethanol/ethyl acetate mixture (1:1) are added 500 mg of 10% palladium on charcoal. The whol^ is placed under a hydrogen atmosphere (P= 10 bars) for one night. The whole is filtered on celite, rinsed and the filtrate is concentrated under reduced pressure leading to 3.57 g of the expected product. Yield: 82% ^H IJMR (CDCl., 300 MHz) -5 ippm) : 7.10-7.35 (hulk aromatic, 7H), 6.69 (d, 2H), 3.98 (s broad, 2H) HPLC: 86% MS: MH' 202 Stage 2: (2-nitro-phenyl}- (4-phenylsulfanyl-phenyl)-amine The product (2.50 g) is obtained according to che method of stage 1 of Example 4, by using 1.25 mL of 2-fluoro-nitrobenzene and 3.57 g of the obtained product of the previous stage in the presence of 2.12 g of potassium tert-butanolate in 10 mL of DMSO. Yield: 66% ^H NMR (CDCl,, 300 MHz) 5 (ppm) : 9.48 (s broad, IH) , 8.22 (d, IH), 7.11-7.42 {bulk aromatic, IIH), 6.8 3 (m, IH) , HPLC: 96% MS: [M+Na]" 345 Stage 3: N- [4-phenylsulfanyl-phenyl]-benzBne-l,2-diamine The product (2 g) is obtained by catalytic hydrogenation by using 2.50 g of the derivative obtained previously in the presence of 250 mg of 10% palladium on charcoal in 3 0 mL of an ethanol/ethyl acetate mixture (1:1). Yield: 88% HPLC: 92% MS: MH" 2 93 Stage 4: {4-phenylsulfany1-phenyl)-(2~piperidin-l-yl-phenyl)-amine The product (1.37 g) is obtained according the method of stage 3 of Example 4, by using 2 g of the previous derivative as starting product, 932 ]ih of dibromopentane and 2.86 mL of DIPEA in 40 mL of toluene. Yield: 55% ^H NMR {CDCl,, 300 MHz) 6 (ppm): 6.87-7.41 (bulk aromatic, 13H), 5.78 (s broad, IH), 2.84 (m, 4H), 1.74 (m, 4H), 1.60 (m, 2H) HPLC; 98% MS: MH"" 361 Stage 5: N- (4-phenylsulfanyl-phenyl) -N- (2-piperidin-l-yl-phenyl)-hydrazine (s) The product (300 mg) is obtained according to the method of stage 4 of Example 1, by using 800 mg of the previous derivative as starting product and 888 mg of sodium nitrite in 5 mL of acetic acid leading to the nitroso intermediate which is reduced by 316 mg of lithium aluminium hydride {4 equivalents) in 5 mL of tetrahydrofurane. Yield: 36% 'H NMR (CDC13, 300 MHz) 6 (ppm): 6.92-7.2 6 (bulk aromatic, 13H) , 4.71(s broad, 2H) , 2.84 (m, 4H) , 1.58 (m, 4H) , 1.47 (m, 2H) HPLC: 90% MS: MH* 376 Stage 6: methyl 5~bromO'-2~methoxy-4-[N-(4-phenyl-sulfar.yl-phenyl) -N- (2-piperidin-l-yl-phenyl) -hydrazino-carbonylmethyl]-benzoate The product {34 0 mg) is obtained according to the method of stage 3 of Example 6, by using 300 mg of the previous hydrazine as substrate and 266 mg of the acid of preparation 2 as a co-substrate in the presence of 168 mg of EDCI and 118 mg of HOBt in 2.5 mL of dimethylformamide. Yield: 64% \¥ NMR (CDCls, 300 MHz) 5 ippm} : 5.34 (s brosd. IH) , 7.99 (2s, IH), 6.79-7.53 (bulk aromatic, 14H) , 2 .70-3.92 (3s, 8H), 2.71 (m, 4H), 1.48 and 1.60 (2m, 6H) HPLC: 91% MS: MH^ 560/662 Stage 7: 5-broiao-2-methoxy~4- [N- (4-phenylsulfanyl-phenyl) -N- (2-piperidin~l-yl-phenyl) -hydrazinocarbonyl-methyl]-benzoic acid hydrochloride (22) The product (108 mg) is obtained as a hydrochloride according to the method of stage 6 of Example 2, by using as a substrate the product obtained at the previous stage. Yield: 83% MP: 158-166 °C Elementary analysis calculated for C33H32BrNjO4S.lHCl.lH2O: C, 56.54; H, 5.03; N, 5.99. Found: C, 55.59; H, 4.96; N, 5.84. HPLC: 95% MS: MH' 646/648 Examples 23 and 24: 4-[N-{4-benzenesulfonyl-phenyl)-N-(2-piperidin-l-yl-phenyl)-hydrazinocarbonylmethyl]-5-broino-2-methoxy-benzoic acid hydrochloride (23) and 4-[N-(4-benzenesulfinyl-phenyl)-N-(2-piperidin-l-yl-phenyl) -hydrazinocarbonylmethyl] . '5-bromo-2-inethoxy-benzoic acid hydrochloride (24) Stage 1: methyl 4- [N- (4-benzenesulfonyl-phenyl) ~N- (2-piperidin-l-yl-phenyl)-hydrazinocarbonylmethyl]-5-bromo-2-methoxy-benzoate and methyl 4-[N-(4-benzene-sulfinyl-phenyl)-N- (2-piperidin-l-yl-phenyl)-hydrazino-carbonylmBthyl]-5- bromo-2-methoxy~ben3oate To a solution of 100 mg of the obtained product of stage 6 of Example 22 in 3 mL of dichloromethane is added an excess of metachloroperbenzoic acid (2 equivalents and 2 other equivalents over time) until total disappearance of the starting product (tracked by TLC). The reaction crude production is filtered, the filtrate is washed with a saturated solution of sodium sulfite and then sodium bicarbonate. The collected organic phases are dried on magnesium sulfate and then evaporated under reduced pressure leading to a mixture which is purified by silica gel chromatography (petroleum ether/ethyl acetate 60:40). 35 mg of each of the esters are obtained - sulfonyl and sulfinyl forms respectively -. Yield (sulfonyl): 33% HPLC: 83% MS: MH' 692/694 Yield (sulfynyl): 34% HPLC: 83% MS: MH^ 676/778 Stage 2: 4~ [N- (4-benzenesulfonyl-phenyl} -N- (2-piperidin-l-yl-phenyl) -hydrazinocarbonylmethyl] -5-hromo-2-inethoxy-benzoic acid hydrochloride (23) The product (20 mg) is obtained as a hydrochloride according to the method of stage 6 of Example 2, by-using as a substrate the sulfonyl derivative obtained I in the previous stage. Yield: 55% Elementary analysis calculated for Cs-jHiijErNrjOfiS . 0 . 75HC1 : C, 56.15; H, 4.68; N, 5.95. Found: C, 56.09; H, 4.65; N, 5.67. HPLC: 84% MS: MH"" 678/680 Stage 2: 4- [N- (4-benzeneBulfinyl-phenyl) -N- (2-piperidin-1-yl-phenyl) -hydrazinocarbonylmethyl] -5-I bromo-2-methoxy~benzoic acid hydrochloride (24) The product (23 rag) is obtained as hydrochloride according to the method of stage 6 of Example 2, by using as a substrate the sulf inyl obtained in the previous stage. Yield: 63% Elementary analysis calculated for C33H,2BrN-iOr,S . IHCI . 1. 5H2O : C , 54 . 59 ; H, 5.00; W, 5.79. Found: C, 54.56; H, 4.91; N, 5.54. HPLC: 85% I MS: MH' 662/664 Example 25: 2-methoxy-4-{(E)-2-[N-(4-methoxy-phenyl)-N-(2-methyl-6-pipGridin-l-yl-phenyl)-hydrazinocarbonyl]-vinyl}-benzoic acid hydrochloride (2 5) stage 1: methyl 2-methoxy-4-{ (E)-2-[N-(4-methoxy-phenyl) -N- (2-inethyl-6-piperidin-l-yl-phenyl) -hydrazino-carbonyl]-vinyl}-benzoate The product (2 00 rag) is obtained according to the method of stage 3 of Example 6, by using 15 0 mg of the hydrazine of Example 7 as a substrate and 125 rag of the acid of preparation 4 as co-substrate in the presence of 102 mg of EDCI and 72 rag of HOBt in 1 . 5 mL of dimethylforraamide. Yield: 78% ^H HMR (Ci:Cl3, 300 MHz) 5 (ppm) : 10.47 and 10.10 (2s broad, IH) , 7.95 (m, 2H) , 7.20-7.48 (m, 6H) , 6.65-7.10 (m, 4H), 4.11 (2s, 6H), 3.98 (s, 3H], 2.91 and 3.11 (m, 3H), 2.61 (m, 4H), 1.85 (m, 6H) HPLC: 98% MS: MH"* 53 0 Stage 2; 2-methoxy-4-( (E) -2- [N- (4-ittethoxy-phenyl) -N- (2- methyl-6-piperidin-l-yl-phenyl) -hydrazinocarbonyl] -vinyl}-benzoic acid hydrochloride (25) The product (149 mg) is obtained as a hydrochloride according to the method of stage 6 of Exaraple 2, by using as a substrate the product obtained in the previous stage. Yield: 71% Elementary analysis calculated for C3aH33N305. IHCl . 1 . 5H2O: C, 62.22; H, 6.44; N, 7.26. Found: C, 62.45; H, 6.34; N, 7.12. HPLC: 94% MS: MH"" 516 Example 26: 5-bromo-2-inethoxy-4-{ (£) -2- [N- {4-inethoxy- phenyl)-N-(2-methyl-6-piperidin-l-yl-phenyl)-hydrazino¬carbonyl] -vinyl}-benzoic acid hydrochloric (26) stage 1: methyl 5'~bromo-2-jnethoxy-4~{ (E)-2-[N-(4-methoxy-phenyl) -N-~. (2-methyl-6-piperidin-l-yl-phenyl} -hydrazinocarbonyl] -vinyl}-benzoate The product (234 mg) is obtained according the method of stage 3 of Example 6, by using 12 0 mg of hydrazine of Example 7 as a substrate and 134 mg of the acid of preparation 5 as a co-substrate in the presence of 81 mg of EDCI and 57 mg of HOBt in 2 mL of dimethylformamide. Yield: quantitative ^H NMR (CDCI3, 300 MHz) 5 (ppm) : :.0.37 and 9.95 (2s broad, IH), 8.02 (m, 2H), 7.00-7.29 (m, 5H), 6.43-6.88 (ra, 4H), 3.95 (3s, 9H), 2.70 and 2.90 (m, 3H>, 2.40 (m, 4H), 1.60 (m, 6H) HPLC: 87% MS: MH" 508/610 Stage 2: 5-hromo-:i-methoxy-4-( (E) -2- [N- (4~-methoxy-phenyl) -W- (2-methyl~6-piperidin-l-yl-phenyl} -hydrazinocarbonyl]-vinyl}-benzoic acid hydrochloride (26) The product (217 mg) is obtained as a hydrochloride according to the method of stage 6 of Example 2, by using as a substrate the product obtained in the previous stage. Yield: 86% MP: 192-206 °C Elementary analysis calculated for C^cHisBrNiOB.lHCl.lllsO: C, 55.52; H, 5.44; N, 6.47. Found: C, 55.43; H, 5.51; N, 6.37. HPLC: 91% MS: MH" 594/596 Example 27: 4-IN-(4-benzyl-phenyl} - [JJ-(2-methyl-6- piperidin-l-yl-phenyl)-hydrazinocarbonylmethyl]-5- broino-2-inethoxy-benzoic acid hydrochloride (27) Stage X: (4-b&nzyl-phenyl) - (2-methyl-6-nitro-phenyl) - amine The product (1.01 g) is obtained according to the method of stage 1 of Example 4, by using 1.13 g of 2- fluoro-3-methyl-nitrobenzene and 2 g of 4-bei'i2yl- aniline in the presence of 1.31 g of potassium cert- butanolate in 30 mL of DMSO. Estimated yield: 35% ^H NMR (CDCI3, 300 MHz) 5 (ppm) : 8.32 (s broad, IH) , 7.96 (d, 2H), 6 . 68-7.51{bulk aromatic, 10 H) , 3.93 (s, 2H), 2.06 (s, 3H) HPLC: 7 9% MS: MH" 319 Stage 2: N^- (4-benzyl-phenyl) -3-inethyl-henzene-l, 2^ diamine The product (530 mg) is obtained by hydrogenation according to the method of stage 2 of Example 13. Yield: 58% ^H NMR (CDCI3, 3 00 MHz) 5 (ppm); 6.99-7.32 (bulk aromatic, 8H) , 6.68 (d, 2H) , 6.52 (d, 2H) , 3.89 (s, 2H), 2.18 (s, 3H) Stage 3 : (4-benzyl-phenyl} - (2-methyl-6-piperidin-l^yl-phenyl)-amine The product (46 0 mg) is obtained according the method of stage 3 of Example 4, by using 525 mg of the previous derivative as a starting product, 247 jjL of dibromopentane and 760 ^L of DIPEA in 10 mL of toluene. Yield: 71% ^H NMR (CDCI3, 300 MHz) 5 (ppm): 6.92-7.31 (bulk aromatic, lOH) , 6.62 {d, 2H) , 6.17 (s broad, IH) , 3.90 (s, 2H} , 2.72 (m, 4H) , 2.10 (s, 3H) , 1.56 (m, 6H) HPLC: 98% MS: MH"" 3 57 Stage 4 : N- (4-benzyl-phenyl] -N- (2-methyl-6-piperidin-l-yl-phenyl)-hydrazine (t) The product (102 mg) is obtained according the method of stage 4 of Example 1, by using 450 rag of the previous derivative as a starting product and 505 mg of sodium nitrite in 3 mL of acetic acid leading to the nitroso intermediate which is reduced by 192 mg of lithium aluminium hydride (4 equivalents) in 5 mL of tetrahydrofurane. Estimated yield: 22% ^H NMR (CDCI3, 3 00 MHz) 6 (ppm): 7.12-7.29 (bulk aromatic, 6H) , 6.97 (dd, 4H) , 6.75 (d, 2H) , 3.8 8 (s, 2H), 2.80 (m, 4H), 2.08 (s, 3H), 1.52 (m, 6H) HPLC: 64% MS: MH"" 3 72 Stage 5: methyl 4^ [if-(4~benzyl-phenyl)-N-(2-methyl-6-piperidin-1-yl-phenyl) -hydrazinocarbonylmethyl] -5-bromo-2-iaethoxy-benzoate The product (91 m^) is obtained according to the method of stage 3 of Example 6, by using 101 mg of the previous hydrazine and 91 mg of the acid of preparation 2 in the presence of 58 mg of EDCI and 41 mg of HOBt in 4 mL of dimethylfprmamide. Yield: 51% ^H NMR (CDCI3, 300 MHz) 5 (ppra) : 9.97 and 9.79 (s broad, IH) , 7.97 (s, IH) , 6.75- 7.27 (bulk aroraatic, IIH) , 6.51 (d, 2H) , 3.87 (s, 6H) , 3.72 (s, 4H} , 2.74 (m, 2H), 2.37 (s, 3H), 2.36 (m, 2H), 1.40 (m, 6H) HPLC: 96% MS: MH' 656/658 Stage 6: 4-[N-(4-benzyl-phenyl)-N-(2-inethyl-6-piperidin-1-yl-phenyl) -hydrazinocarbonylmethyl] -5-bromo-2-inethoxy-benzoic acid hydrochloride (27) The product (74 mg) is obtained as a hydrochloride according to the method of stage 6 of Example 2, by using as a substrate the product obtained in the previous stage. Yield: 84% MP: 173-187 °C Elementary analysis calculated for C35H36B1-N3O4.lHCl.lH2O: C, 60.31; H, 5.64; N, 6-03. Found: C, 60.36; H, 5.62; N, 5.99. HPLC: 9B% MS: MH" 642/644 Example 28: 5-bromo-2-methoxy-4-[W- {4'-methoxy-bi5h,eriyl--4-YL\ -H- ^2-T!?.et.b.yl-6-pi.pe.rldlii-l-Yl-pb.e.TiYl^ -hydrazinocarbonylmethyl]-benzoic acid hydrochloride (28) Stage X: (4-broiao-pheiiyl} - (2-methyl~6-nitro-phenyl) -amine The product (2.44 g) is obtained according to the method of stage 1 of Example 4, by using 1.8 g of 2-£luoro-3-methyl-nitrobenzene and 3 g of 4-bromo-aniline in the presence of 2.09 g of potassium tert-butandate in 2 0 mL of DMSO. Yield: 68% ^H NMR (CDCI3, 300 MHz) 5 (ppm) : 8.15 (s broad, IH) , 7.96 (d, IH) , 7.07-7.51 (bulk aromatic, 4H) , 6.61 (d, 2H), 2.09 (s, 3H) HPLC: 90% MS: MH' 307/309 stage 2: if- (4-bromo-phenyl) -3-iaethyl-benzene~l, 2- di amine The product (2.2 g) is obtained according to the method of stage 2 of Example 1, by using 2 .44 g of the previous derivative as a starting product and 9 g of tin chloride hydrate in 30 mL of ethanol. Yield: quantitative ^H NMR (CDCI3, 300 MHz) 6 (ppm): 7.22 (s, IH), 7.03 (t, 1H>, 6.45 (m, 3H), 6.43 (d, 2H), 4.98 {s broad, IH}, 2.14 (s, 3H) HPLC: 99% MS: MH' 277/279 Stage 3 : (4-hromo-phenyl) - (2-iBethyl-6-piperidin--l-y^-phenyl)-amine The product (2 g) is obtained according to the method of stage 3 of Example 4, by using 2.2 g of the previous derivative as a starting product, 1.08 mL of dibroTOopentaiie and 3.3 mLi ot DIPEA in 40 mli ot tc.l\je.ne. Yield: 73% ^H NMR (CDCl., 300 MHz) 6 (ppm): 7.26 (m, 2H), 7.03 (t, IH) , 6.94 (d, 2H) , 6.56 (d, 2H) , 6.14 (s broad, IH) , 2.70 (m, 4H), 2.10 (s, 3H), 1.55 (m, 6H) HPLC: 99% MS: MH"* 34 5/34 7 Stage 4: (4'-methoxy-biphenyl-4-yl)-(2-methyl-6-piperidin-1-yl-phenyl)-amine The product (24 8 mg) is obtained according to the method of stage 4 of Example 11, by using 300 mg of the previous derivative as a starting product, 198 mg of phenylboronic acid, 50 mg of palladium tetrakis, llO ™9 of lithium chloride in the presence of 2.17 mL of 3 1 M calcium carbonate solution in 6 mL of a methanol/toluene mixture (1:1) , Yield: 76% ^H NMR (CDCI3, 300 MHz) 5 (ppm): 7.48 (d, 2H), 7.39 (d, 2H) , 6.92-7.03 (m, 5H} , 6.74 (d, 2H) , 6.24 (s broad, IH), 3.84 (s, 3H), 2.74 (m, 4H}, 2.16 (s, 3H}, 1.56 (m, 6H) HPLC: 81% MS: MH"" 37 3 Stage 5: N- (4 ' -methoxy-biphenyl-4-yl) -N- (2-methyl-6' piperidin-1-yl-phenyl)- hydrazine (u) The product {92 mg) is obtained according to the method of stage 4 of Example 1, by using 24 7 mg of the previous derivative as a starting product and 265 mg of sodium nitrite in 3 mL of acetic acid leading to the nitroso intermediate which is reduced with 101 mg of lithium aluminium hydride (4 equivalents) in 5 mL of tetrahydrofurane with reflux. Yield: 35% ■^H NMR (CDCI3, 300 MHz) 5 (ppm): 7.48 (d, 2H) , 7.38 (d, 2H) , 7.17 (t, IH) , 6.86- 7.03 (m, 6H) , 4.90 (s broad, 2H), 3.83 (s, 3H), 2.95 (m, 2H), 2.69 (m, 2H), 2.11 (s, 3H), 1.51-1.66 {m, 6H) HPLC: 95% MS: MH*" 3 8 8 Stage 6: methyl 5-broino-2-i[iethoxy-4-[ N~ (4 ' -tnethoxy-hiphenyl-4-yl) -N- (2-i[iethyl-6-piperidin-l-yl-phenyl) -hydrazinocarbonylmethyl] -henzoate The product (24 mg) is obtained according to the method of stage 3 of Example 6, by using 92 mg of the previous hydrazine and 79 mg of the acid of preparation 2 in the presence of 50 mg of EDCI and 35 mg of HOBt in 2.5 mL of dimethylformamide. Yield: 15% ^H NMR (CDCI3, 3 00 MHz) 5 (ppm) : 8.00 {s, IH) , 6.85-7.51 (bulk aromatic, 10 H), 6.62 {d, 2H), 3.72-3.88 (m, IIH) , 2.81 (m, 2H) , 2.43 (m, 5H) , 1.25-1.56 (m, 6H) HPLC: 87% MS: MH" 672/674 Stage 7; 5-bromo-2-iaethoxy-4- [N- (4 ' -inethoxy-biphenyl-4-yl) -N- (2-inethyl-6-piperidin-l-yl-phenyl) -hydrazino-carbonylmethyl]-benzoic acid hydrochloride (28) The product {13 mg) is obtained as a hydir.'^chloride according to the method of stage 6 of Example 2, by using as a substrate the product obtained in the previous stage. Yield: 52% Elementary analysis calculated for CasH^sBrN^Os.lHCl.l.BHaO: C, 58.22; H, 5.58; N, 5.82. Found: C, 58.06; H, 5.63; N, 5.58. HPLC: 82% MS: MH" 658/660 Example 29: 5-bromo-4- [N-cyano-phenyl)-N- {2-methyl-6-piperidin-l-yl-phenyl)-hydrazinocarbonylmethyl]-2-methoxy benzoic acid hydrochloride (2 9) Stage 1: tert-butyl N-(2-methyl-6-nitro-phenyl)-hydrazino-carboxylate To 250 mg of 2-fluoro-3-methyl-nitrobenzene in 5 mL of DMSO are added 1.065 g of commercial tert-butoxycarbonylhydrazine {5 equivalents). The whole is brought to 100°C for 10 min under microwave heating. The medium is hydrolyzed and then extracted with ethyl acetate several times. The organic phases are collected, dried on magnesium sulfate, filtered and evaporated under reduced pressure leading to a residue which is purified by chromatography on silica gel (cyclohexane/ethyl acetate: 80/20). 342 mg of product corresponding to the expected product are obtained. Yield: 80% ^H NMR (CDCI3, 250 MHz) 6 (ppm): 7.86 (d, IH), 7.35 (d, IH) , 6.97 (t, IH) , 6.40 (s broad, IH) , 1.34 (s broad, 9H) HPLC: 98% Stage 2 : tert-butyl N- (4-cyano-phenyl) -N- (2-inethyl-s-ni tro-phenyl) -hydrazinocarboxylate . To 1.5 g of the product obtained in the previous stage in 10 mL of dichloromethane are added at 0°C, 2.45 g of activated manganese oxide {5 equivalents). The whole is stirred at room temperature for 3 0 min, until complete disappearance of the starting product (tracked by TLC) . The oxidized intermediate is filtered on celite, rinsed with dichloromethane and then concentrated Under reduced pressure without any other form of purification. The thereby obtained tert-butyl azocarboj^ylate derivative is immediate! 3.' tak.en up in 10 mL of methanol to which are successively ^dded 1.27 g of 4-cyanophenylboronic acid (1.6 equivalents) and 54 mg of copper acetate hydrate {0.05 equivalents). The whole is refluxed for 24 hrs until complete disappearance of the oxidized intermediate. The reaction medium is hydrolyzed and then extracted with ethyl acetate several times. The organic phases are washed with water, then with brine and finally dried on magnesium sulfate, filtered and evaporated Under reduced pressure. The obtained residue is purified by si 1ica gel chromatography (dichloromethane/cyclohe^ane: 1/1) leading to 1.13 g of the expected product. Yield: 57% ^H NMR (CDCI3, 300 MHz) 6 (ppm): 7.98 (d, IH), 7.67 (t, 2H>, 7.49 (m, 3H), 6.60 fd, 2H), 2.49 (s, 3H), 1.4S (s, 9H) HPLC: 78% Stage 3: tert-butyl N- (2-amino-6-methyl-phenyl) -tf- (4-cyano-phenyl)-hydrazinocarboxylate 982 mg of the product are obtained by catalytic hydrogenation in the presence of 110 mg of 5% palladium on charcoal in 50 mL of ethanol from 1.13 g of the product obtained in the -previous stage. Yield: 97% ^H NHR {CDCI3, 300 MHz) 6 (ppm): 7.48 (d, 2H), 7.09 (m, IH} , 6.62 (m, 4H) , 4.78 (s broad, 2H) , 4.40 (s broad, IH), 2,02 (s, 3H), 1.50 (s, 9H) HPLC: 80% Stage 4 : tert-butyl N- [2- (5-hromo-pentanoylaiaino) -6- methylphenyl] -N- (4-cyano-phenyl) -hydrazlnocarboxylate To 980 mg of the obtained product of the previous stage in 8 mL of dichloromethane in the presence of 82 0 ]JL of DIPEA (2 equivalents) are added drop wise and at room temperature 388 uL of 5-broraovaleryl chloride. After 20 minutes, the reaction crude product hydrolyzed by a 1 N hydrochloric acid solution is extracted with dichloromethane several times, The organic phases are dried on magnesium sulfate, filtered and concentrated under reduced pressure leading to 1.4 g of the expected product. Yield (estimation): 96% 'H NMR (CDCI3, 3 00 MHz) 6 (ppm) : 10.03 (s, IH), 8.28 (d, IH), 7.4 9 (d, 1H>, 7.34 (t, 2H), 6.95-7.2 0 (m, 3H), 3.43 (m, 2H), 3.30 (t, 2H), 2.51 (t, 2H), 2.34 (m, 2H), 2.07 (s, 3H), 1.53 (s, 9H) HPLC: 56% stage 5: tert-butyl N- (4~cyano-phenyl) -N- [2-metbyl-6-(2-oxo-piperidin-1-yl) -phenyl] -hydrazinocarhoxylate To 1.4 g of the obtained previous product in 5 mL of DMF are added 225 mg of sodium hydride (2 equivalents) at 0°C. After 20 minutes at room temperature, the reaction crude product is hydrolyzed and then extracted with ethyl acetate several times, The collected organic phases are washed with water and then with brine and finally dried on magnesium sulfate, filtered and concentrated under reduced pressure leading to 1.1 g of the expected product. Yield (estimation): quantitative Stage 6: tert-butyl N~ [4- (amino-methyl)-phenyl]-N- (2-methyl-6-piperidin-l-yl-phenyl)-hydrazinocarboxylate To 440 mg of the product obtained from the previous stage in 3 mL of THF are added 4 93 |iL of borane dimethylsulfide (5 equivalents). The whole is refluxed for 1 hr. The reaction crude product is hydrolyzed and extracted with ethyl acetate several times. The organic phases are collected, washed with water and then with a 1 N hydrochloric acid solution. The aqueous phase is taken up with a saturated solution of sodium bicarbonate and then extracted with ethyl acetate. The organic phases are collected, dried on magnesium sulfate, filtered and concentrated under reduced pressure leading to 308 mg of the expected product. Yield [estimation): 71% Stage 7: tert-butyl N- [4-(acetylamino-methyl)-phenyl]-N- (2-methyl-6-piperidin-l-yl-phenyl)-hydrazino¬carboxylate To a solution of 300 mg of the product obtained from the previous stage in 10 mL of tetrahydrofurane under an inert atmosphere are added 267 yL of DIPEA (2 equivalents) and 76 viL of acetic anhydride (1.4 equivalents). The whole is stirred at room temperature for 3 0 minutes until complete disappearance of the starting product {tracked with TLC). The reaction medium taken up in ethyl acetate is hydrolyzed with a 1 N hydrochloric acid solution and extracted several times. The aqueous phase is then taken up again with a sodium bicarbonate solution until a pH of 8 and extracted with ethyl acetate. The organic phases are collected, dried on magnesium sulfate, filtered and evaporated under reduced pressure. The obtained residue is purified by silica gel chromatography (ether and then dichloromethane) leading to 165 mg of the expected product. Yield (estimation): 51% ^H NMR (CDCl:i, 300 MHz) 5 (ppm) : 8.92 (s broad, IH) , 7.18 (d, IH), 7.07 (m, 4H), 6.52 (d, 2H), 5.60 (s broad, IH) , 4.32 (m, 2H) , 2.80 (m, 2H) , 2.65 (m, 2H) , 2.31 (s, 3H), 2.01 (s, 3H), 1.6 0 (m, 6H), 1.44 (s, 9H) Stage 8: methyl 4'{N- [4- (acetylamino-methyl) -phenyl] -N-(2-methyl-6-piperidin-1-yl-phenyl) -hydrazinocarhonyl-mBthyl}-5~bromo-2-'methoxy-benzoate To a solution of 51 mg of the acid obtained in preparation 2 (2 equivalents) in 2 mL of dichloromethane are added 14.4 pL of oxalyl chloride {2 equivalents) and 1 drop of dimethylf ormamide. The whole is stirred for 20 min at room temperature and then evaporated under reduced pressure. To the thereby obtained acid chloride, taken up again in 1 mh of acetonitrile, are successively added a solution of 3 8 mg of the previous ester in 1 mL of acetonitrile and 1 mL of 4 N hydrochloric acid in dioxane. The whole is placed for 10 minutes under microwave heating at lOO°C. The reaction medium is hydrolyzed and then extracted with eChyl acetate several times. The aqueous pha^e is then basified with a 1 N soda solution and extracted with ethyl acetate and then with dichloromethane. The organic phases are collected, dried on magnesium sulfate, filtered and then evaporated under reduced pressuj^e. With a silica gel chromatography of the residue (dichloromethane/ethanol: 98/2) 18 mg of the expected product may be obtained. Yield: 34% ^H NHR (CDCI3, 300 MHz) 5 (ppra) : 10.05 et 9.83 {2s broad, IH) , 7.99 {s, IH) , 7.0-8 (m, 2H) , 7.05 (m, 4H) , 6.52 (d, 2H), 5.67 (s broad, IH), 4.29 {d, 2H), 3.88 (s, 3H) , 3.73 {m,s, 2H) , 3.71 (s, 3H) , 2.75 (m, 2H) , 2.40 (iti, 2H) , 2.37 {s, 3H) , 1.98 {s, 3H) , 1.46 (m, 6H) HPLC; 37.3% MS: MH' 637/639 Stage 9' 4-{N- [4- (acetylamino-methyl)-phenyl]-N- (2^ methyl^S-piperidin-1-yl-phenyl)-hydrazinocarbonyl-inethyl}-5-broiiio-2-inethoxy-beiizoic acid hydrocfaltJ^^ide (29) The product (13.8 mg) is obtained as a hydrochloride according to the method of stage 6 of Example 2 / by using as a substrate the product obtained with the previovis stage. Yield: 75% HPLC: 31% MS: MH' 623/625 Example 30: 4- [N-{4-benzoyl-phenyl)-N-(2-piperidin-l- yl-phe:iyl) -hydrazinocarbonylmethyl] -5-broino-2-inethoxy benzoic acid hydrochloride {30) Stage X' (4-henzoyl-phenyl)-{2-nitro~phenyl)-amine The piToduct (770 mg) is obtained according to the method of stage 1 of Example 4, by using 1 .5 mL of 2- fluoro-nitrobenzerie and 4.2 g of 4-aminobenzophenone in the presence of 2.54 g of potassium tert-butanolate in 4 0 mL of DMSO. Yield: 17% HPLC: 86% MS: MH* 319 Stage 2: N-(4 -Benzoyl-phenyl)-henzene-1,2-diamine The product (880 nig) is obtained according to the method of stage 2 of Example 1, by using 770 mg of the previous derivative as a starting product and 2.73 g of. tin chloride hydrate in 15 mL of ethanol. Yield: quantitative 'H NMR (CDCl:), 3 00 MHz} 5 (ppm) : 7.74 (t, 4H}, 7.36- 7.53 {m, 3H), 7.l3 (m, 2H), 6.7 0-6.85 {m, 4H), 5.63 (s broad, IH), 3.80 [s broad, IH) HPLC: 82% MS: MH^ 28 9 Stage 3 ; (4-1)61130/1-phenylJ - f2-piperidin-l-yl-phenyl) -amine The product {53 0 mg) is obtained according to the method of stage 3 of Example 4, by using 697 mg of the previous derivative as a starting product, 330 |aL of dibromopentane and 1.01 mL of DIPEA in 15 mL of toluene. Yield: 62% ^H NMR (CDCI3, 300 MHz) b (ppm): 7.80 (dd, 4H) , 7.45- 7.56 (m, 4H) , 6.96-7.18 (m, 6H) , 2.84 (m, 4H) , 1.60- 1.74 (m, 6H) HPLC: 100% MS: MH^ 35 7 Stage 4: N-(4~benzoyl-phenyl)-N-(2-piperidin-l-yl-phenyl)-hydrazine (v) To a solution of 100 mg of the previous compound in 10 niL of DMF are added 14 mg of sodium hycii:"ide (1.2 equivalents) and the whole is stirred at room temperature for 45 minutes. 2.3 raL of a freshly prepared 0.15 M solution in monochloramine ether (1.2 equivalents) (J. Org. Chem. 2004, 69, 1368-1371) is added. After 5 minutes, the medium is treated by a saturated solution of Na2S203, taken up again with water and then extracted with ether several times. The organic phases are dried on magnesium sulfate, filtered and co'icentrated under reduced pressure. The obtained residue is purified by silica gel chromatogi-'aphy (petroleum ether/ethyl acetate: 95/5) leading to 15 mg of the expected product. Yield: 72% ^H NMR (CDCI3, 250 MHz) 6 (ppm): 7.73 (d, 4H), 7.4& (m, 3H) , 7.2 5 (m, 2H) , 7.05-7.17 (m, 4H) , 4.8 9 (s bfOad, 2H>, 2.91 {m, 4H), 1.57 fm, 6H} HPLC: 100% ns-. v,v: ^l2 stage 5: methyl 4- [N- (4-benzoyl~phenyl)-N- (2-piperidin- 1-yl-phenyl)-hydrazinocarbonylmethyl]-5-bromo-2- methoxy-henzoate The product (83 mg) is obtained according to the method of stage 3 of Example 6, by using 70 mg of the preceding hydrazine and 64 mg of the acid of preparation 2 in the presence of 41 mg of EDCI and 2 8 mg of HOBt in 1.5 mL of dimethylformamide. Yield: 66% ^H NMR (CDCl., 300 MHz) 5 (ppm): 9.36 (s broad, IH) , 7.99 (s, IH), 6.80-7.76 (bulk aromatic, 14 H), 3.8^ (s, 3H), 3.8 0 (S, 2H), 3.72 (s, 3H), 2.75 (m, 4H), 1.54 (m, 6H) HPLC: 100% MS: MH"* 656/658 Stage 6: 4- [N- (4-benzoyl-phenyl) -N- (2-piperidin~l-yl-phenyl) -hydrazinocarbonylmethyl] ~5-bromo-2--niethoxy benzoic acid hydrochloride (30) The product (31 mg) is obtained according to the method of stage 6 of Example 2, by using as a substrate the product obtained in the previous stage. Yield: 37% Elementary analysis calculated for C34H32BrN305.1HC1.1.5H20: C, 57.84", H, 5.14; N, 5.95. Found: C, 58.04; H, 5.13; N, 5.55. HPLC: 100% MS: MH* 642/644 Example 31: 5-bromo-4- [N-cyano-phenyl) -N- (2-methyl-6-piperidin-l-yl-phenyl)-hydrazinocarbonylmethyl]-2-methoxy benzoic acid hydrochloride (31) Stage 1: tert-butyl N- (4-cyano-phenyl) -N- (2-inethyl-6-piperidin-1-yl-phenyl)-hydrazinocarboxylate To 280 mg of the product obtained in stage 5 of Example 2 9 in 2 mL of tetrahydrofurane are added 3.3 mL of a 1 M borane solution in tetrahydrofurane (5 equivalents}. The whole is refluxed for 3 hrs. The reaction crude product is poured on a 1 N acid hydrochloric solution and extracted with ethyl acetate several times. The aqueous phase is basified by a 1 N soda solution and extracted with dichloromethane. The different organic phases are collected, washed with water and then with a saturated solution of NaCl, dried on magnesium sulfate, filtered and concentrated under reduced pressure. The obtained residue is purified by silica gel chromatography (dichloromethane/ethyl acetate: 98/2) leading to 82 mg of expected product. Yield: 30% ^H NMR (CDCI3, 300 MHz) 6 (ppm) : 8.92 (s broad, IH) , 7.46 (d, 2H> , 7.21 {m, IH) , 7.06 (t, 2H) , 6.72 (m, 2H) , 2.74 (m, 4H), 2.29 (s, 3H), 1.60 (m, 6H}, 1.43 (s, 9H> Stage 2: methyl 5-bromo-4- [N- (4-cyano-phenyl) -N~ (2^ methyl-6~piperidin-l~yl-phenyl) -hydrazino-carbonyl-' methyl] -2-inethoxy-benzoate The product (32 mg) is obtained according to the method of stage 8 of Example 31, by using 42 mg of the pr(?duct obtained in the previous stage as a substrate and 34 mg of the acid of preparation 2 as a co-substrate. Yield: 56% ^H NMR (CDCI3, 300 MHz) 5 (ppm): 9.78 (s, IH), 7.93 (s, IH), 7.45 (d, 2H), 7.24 (m, 2H), 7.01 (m, 2H), 6.62 (m, 2H), 3.88 (s, 2H), 3.37 (s, 6H), 2.70 (m, 2H), 2.4$ (m, 2H), 2.35 (s, 3H), 1.42 (m, 6H) HPLC: 94% MS: MH" 591/593 Stage 3 : 5-broino-4- [K- (4-cyaiio-phenyl) -N- (2-methyl^€- piperidin-l-yl-phenyl) -hydrazinocarbonylmethyl] -2- methoxy-benzoic acid hydrochloride (31) The product (16.4 mg) is obtained as a hydrochlcride according to the method of stage 6 of Example 2, by using as a substrate the product obtained in the previous stage. Yield: 49% HPLC: 98% MS: MH^ 577/579 Example 32 : 4- [N- (4 '-acetyl-biphenyl-4-yl)-W- (2-methyl-6-piperidin-l-yl-phGnyl)-hydrazinocarbonylmethyl]-5-bromo-2-methoxy-benzoic acid hydrochloride (32) Stage 1: (4'~acetyl-biphenyl-4-yl)-(2-methyl-6-piperidin-1-yl-phenyl)-amine The product (1.35 g) is obtained according to the method of stage 4 of Example 11, by using 2.6 g o£ the derivative obtained in stage 3 of Example 28 as a starting product, 248 g of 4-acetyl-phenylbGronic ^cid, 307 mg of [1,1'-bis(diphenylphosphino)ferrocene]-dichloropalladium (II) and 4.58 g of cesium fluoride in 15 0 mL of dioxane. Yield: 47% ^H NMR (CDCI3, 200 MHz) 5 (ppm): 7.98 (d, 2H>, 7.6$ (d, 2H) , 7.51 (d, 2H> , 7.03 (m, 3H) , 6.76 (d, 2H) , 6.29 (s broad, IH) , 2.7 5 (m, 4H) , 2.6 3 (s, 3H) , 2.17 (s, 3H) , 1.58 (m, SH) SM: MH*" 385 Stage 2; [4 • - (2--methyl- [1, 3] dithian-2-yl) -biphenyl^'i-yl] ~ (2~niethyl-6-piperidin-1-yl-phenyl) -amine To a solution of 788 mg of the derivative obtained in the previous stage in 14 mL of dichloromethane are successively added 260 pL of propanedithiol (1.25 equivalents^ and 3,S0 v^ of boron trifluO-'^ide complexed with diethyl ether. The whole is stirred for 2 days at room temperature until disappearance of the starting product. The reaction medium is poured on a 2 N soda solution and then extracted with dichloromethane several times. The organic phases are washed with a saturated solution of sodium chloifide, dried on sodium sulfate, filtered and concentrated under reduced pressure leading to 970 mg of the expected product. Yield: quantitative ^H NMR (CDCI3, 200 MHz) 6 (ppm): 7.96 (d, 2H), 7.58 (d, 2H), 7.48 (d, 2H), 7.03 (m, 3H), 6.77 (d, 2H), 6.26 (s broad, IH) , 2 .76 (m, 8H} , 2.18 (s, 3H) , 1.95 (m, 2H) , 1.84 (S, 3H), 1.54 (m, 6H) stage 3: N-[4•-(2-methyl-[1,3]ditbian~2~yl)-biphenyl-4-yl]-N- (2-methyl~6~piperidin-l-yl-phenyl)-hydrazine (w) The product (83 5 mg) is obtained according to the method of stage 4 of Example 1, by using 970 mg o£ the previous derivative as a starting product and 1.ll g of sodium nitrite in 6 mL of acetic acid leading to the nitroso intermediate which is reduced by 8.2 mL of a 1 M lithium aluminium hydride solution in ether (4 equivalents) in 8 mL of ether with reflux. Yield: 83% ^H NMR (CDCI3, 200 MHz) 5 (ppm): 7.92 (d, 2H), 7.57 {d, 2H), 7.46 {d, 2H), 7.19 {d, IH), 7.05 (t, 2H), 6.90 (d, 2H) , 2.70-2.95 {m, 8H) , 2.12 (s, 3H) , 1.96 [m, 2H) , 1.82 fs , 3H), 1.65 (m, 6H) Stage 4: methyl 5'bromo-2-inethoxy-4{N- [4 ' - {2--methyl-[1, 3] dithian-2-yl) -biphenyl~-4-yl] -N- (2-methyl-6-piperidin~l-yl~phenyl) -hydrazinocarbonylmethyl}-benzoate The product (637 mg) is obtained according to the method of stage 3 of Example 6, by using 600 mg of the previous hydrazine and 4 06 mg of the acid of preparation 2 in the presence of 257 mg of EDCI and 181 mg of HOBt in 4 mL of dimethylformamide. yield: 67% ^H NMR [CDCI3, 200 MHz) 5 (ppm): 9.87 (s broad, IH) , 7.96 (m, 3H), 7.50 (m, 5H), 7.2 0 (d, IH), 7.03 (m, 2H), 6.65 (d, 2H) , 3.88 (s, 3H) , 3.70 {2s, 5H) , 2.75 (m, 8H) , 2.44 (s, 3H) , 1.97 (m, 2H) , 1.81 (s, 3H) , 1.25-1.55 (m, 6H) MS: MH' 774/776 Stage 5: methyl 4-[N-(4 '-acetyl--biphenyl-4-yl)-N-(2- tnethyl-6-piperidin-1 -yl-phenyl) -hydrazinocarbonyl~ methyl] ~5-bromo-2'inethoxy-benzoate To a solution of 30 mg of the derivative obtained in the previous stage in 100 \il, of a tetrahydrofurane/water mixture (1:1) are successively added 17 mg of mercury(II) oxide (2 equivalents) and 10 uL of boron trifluoride complexed with ether (2 equivalents). The whole is stirred at room temperature for 1 hour, until disappearance of the starting product. The reaction medium is poured in a 2 M soda bicarbonate solution and then extracted with ethyl acetate several times. The organic phases are washed with a saturated solution of sodium chloride, dried on sodium sulfate, filtered and concentrated under reduced pressure. Silica gel chromatography (cyclohexane/ethyl acetate: 70/30) is able to isolate 19.5 mg of the desired product, yield: 73% 'H NMR (CDCI5, 200 MHz) 5 (ppm) : 9.88 (s broad, IH) , 7.97 (m, 3H) , 7.62 (d, 2H) , 7.48 (d, 2H) , 7.21 (d, IH) , 7.03 (m, 2H> , 6.67 (d, 2H) , 3.89 (s, 3H) , 3.77 (2s, 5H), 2.80 (m, 2H), 2.62 (s, 3H), 2.42 (ra+s, 5H), 1.30-1.50 (m, 6H) MS: MH" 684/686 Stage 6: 4- [N- (4 '-acetyl-i>iphenyl~4-yl) -N- (2-iaethyl~6-piperidin-1-yl'phenyl) -hydrazinocarhonylmsthyl] -5-broino-2-niethoxy-benzoic acid hydrochloride (32) The product (115 mg) is obtained as a hydrochloride form according to the method of stage 6 of Example 2, by using as a substrate the product obtained in the previous stage. yield: 34% 'H NMR (DMSO, 400 MHz) 5 (ppm): 7.99 (m, 3H), 7.37-7.81 (m, 7H), 7.37 (s, 1H>, 6.78 (m, 2H), 4.24 (d, IH), 4.03 (d, IH), 3.79 (s, 3H), 3.20-3.6 0 (ra, 4H), 2.57 (s, 3H), 2.28 (s, 3H), 1.51-1.86 (m, 6H) HPLC: 96% MS: MH* 570/672 Example 33: 5-broino-2-methoxy-4- [N- (4 •-inethoxy-2-methyl-biphenyl-4-yl}-N-(2-methyl-6-piperidin-l-yl-phenyl)-hydrazinocarbonylmethyl]-benzoic acid hydrochloride (33) Stags 1: (4-bromo^3-methyl-phenyl)-(2-methyl-6~nitro-phenyl)-amine The product (3.90 g) is obtained according to the method of stage 1 of Example 4, by using 2.78 g of 2-fluoro-3-methyl-nitrobenzene and 5 g of 4-bromo-3-methyl-aniline in the presence of 3.22 g of potassium tert-butanolaCe in 70 mL of DMSO. Yield: 68% ^H NMR (CDCI3, 200 MHz) b (ppm) : 8.15 (s broad), 7.96 [d, IH) , 7.43 (d, IH) , 7.37 (m, IH) , 7.10 (t, IH) , 6.65 (m, IH), 6.42 (dd, IH), 2.33 (s, 3H), 2.10 {s, 3H) Stage 2: if- (4-hroino-3-methyl-phenyl) -3-methyl-benzene-1,2-diamine The product (3.2 g) is obtained according to the method of stage 2 of Example 1, by using 3.9 g of the previous derivative as a starting product and 13.7 g of tin chloride hydrate in 60 mL of ethanol. Yield: 90% ^H NMR (CDCI3, 200 MHz) 5 (ppra): 7.29 (d, IH), 7.03 {t, IH) , 6.68 (d, 2H) , 6.47 (d, IH) , 6.28 (dd, IH) , 4.94 (s broad, IH), 2.29 (s, 3H), 2.16 (s, 3H) Stage 3 : (4-hromo-3-iBethyl-phenyl) - (2-methyl-6-piperidin-1-yl-phenyl)-amine The product (3.21 g) is obtained according to the method of stage 3 in Example 4, by using 3.2 g of the previous derivative as a starting product, 1.50 mL of dibromopentane and 4.30 mL of DIPEA in 50 mt- of toluene. Yield: 81% ^H NMR (CDC13, 200 MHz) 6 (ppm): 7.28 (d, IH), 7.04 (m, 3H> , 6.58 (d, IH) , 6.41 (dd, IH) , 6.13 (s broad, IH) , 2.72 (m, 4H), 2.32 (s, 3H), 2.11 (s, 3H>, 1.57 (m, 6H) Stage 4: (4 '~methoxy-2~iBethyl-bipheiiyl-4-yl) - (2-methyl-S-piperidin-l-yl-phenyl-smine The product (1.921 g) is obtained according to the method of stage 4 of Example 11, by usin^; 3 g o£ the previous derivative as a starting product, 1.904 g of 4-methoxy-phenyl boronic acid, 392 mg of palladium tetrakis, 1.062 g of lithium chloride in the presence of 9 mL of a 1 M sodium carbonate solution in 60 rflL of a methanol/toluene mixture (1:1). Yield: 60% ^H NHR (CDCI3, 200 MHz) 5 (ppm): 7.28 (d, 2H), 7.03 (m, 6H) , 6.59 (m, 2H) , 6.26 (s broad, IH) , 3.86 (s, 3H) , 2.T7 (,w, '^Vi) , 2.25 U, 3.H\ , 2.20 (s, 5H\ , 1.63 \m, ^Hi Stage 5: N- (4 ' -methoxy-2-inethyl-hiphenyl~4-yl) -N- (2-methyl-6-piperidin-l-yl-phenyl)-hydrazine (x) The product (385 mg) is obtained according to the method of stage 4 of Example 1, by using 4 90 mg of the previous derivative as a starting product and 515 itig of sodium nitrite in 4 mL of acetic acid leading to the nitroso intermediate which is reduced with 4.8 mL of a 1 M lithium aluminium hydride solution in ether (4 equivalents) in 4.5 mL of ether with reflux. Yield: 80% ^H NMR (CDCI3, 200 MHz) 5 (ppm): 6.90-7.27 (bulk aromatic, lOH) , 6.78 (s broad, IH) , 6.57 (d, IH) , 3.83 (s, 3H), 2.92 (m, 4H), 2.22 (s, 3H), 2.12 (s, 3H}, 1-68 (m, 4H), 1.53 (m, 2H) stage 6: methyl 5-broino~2 —nieth.oxy—4— [N~ (4 '—metJioxy—2 — methyl-hiphenyl-4~yl) -N- (2~methyl-6-piperidin-l-yl'-phenyl) -hydrazinocarbonylmethyl] -benzoate The product (450 mg) is obtained according to the method of stage 3 of Example 6, by using 381 rag of the previous hydrazine and 316 mg of the acid of preparation 2 in the presence of 200 rag of EDCI and 144 mg of HOBt in 3.8 mL of dimethylformamide. Yield-. 69% ^H NMR (CDCI3, 200 MHz) 6 (ppm) : 10.06 et 9.84 (2 s broad, IH) , 8.01 [s, IH) , 7.20 (m, 4H), 6.89-7.02 (m, 5H), 6.50 (s, IH), 6.3 8 (d, IH), 3.89 (s, 3H), 3.84 (s, 3H), 3.76 (m, 2H), 3.72 (s, 3H), 2.80 (m, 2H), 2.45 {m, 5H), 2.18 (s, 3H), 1.3 0-1.5 8 (m, 6H) Stage 7: 5-bromo-2-iaethoxy~4- [N- (4 ' -Inethoxy-2-Ittethyl~ biphenyl-4-yl) -W- (2-methyl-6-piperidin-l-yl-phenyl)-hydrazinocarbonylmethyl]-benzoic acid hydrochloride (33) The product {264 mg) is obtained as a hydrochloride according to the method of stage 6 of Example 2, by using as a substrate the product obtained in the previous stage. Yield: 67% 'H NMR (DMSO, 200 MHz) b (ppm) : 11.79 (s broad, IH) , 11.44 (s broad, IH) , 7.96 (d, IH) , 7.81 (s, IH) , 7.70 (m, 2H), 7.34 (s, IH), 7.23 [d, 2H), 6.99 (d, IH), 6.75 (d, 2H), 6.44 (s, IH), 6.42 (d, IH), 4.10 (m, 2H), 3.78 (S, 6H) , 3.4 0 (Tfi, 4H) , 2.27 (s, 3H) , 2.19 (s, 3H) , 1.53-1.86 (m, 6H) HPLC: 98,5% MS: MH' 672/674 RESULTS OF BIOLOGICAL ACTIVITY Activity of molecules against the papilloma virus may¬be evaluated in different in vitro and cell tests such as those described by Chiang efc al. (1992), Proc. jVatl. Acad. Sci . USA, 89: 5799-5803 or further by White et al. (2003), Journal of Biological Chemistry, 278: 26765-26772. Example 34 ; Pharmacological studies of the compoun A reporter 'rep1icon' vector containing the viral replication origin of HPV11/HPV6 (also called LCRs which bear sites for binding the El and E2 proteins of HPV) and the gene coding for firefly luciferase under the transcriptional control of the SV40 promoter were built. It was checked that the presence of the HPV replication origin does not have any transcriptional effect on expression of the gene of luciferase, this in the presence or in the absence of viral El or E2 proteins. Co-transfection of this replicon vector and of vectors for expressing HPV El and E2 proteins leads to an increase in luciferase activity depending on the presence of El and E2 and expresses the increase in the number of reporter vectors. This is due to the activity of the viral El and E2 proteins which allow replication, in mammal cells, of this replicon vector containing a viral replication origin. The chemical compounds were evaluated for their activity inhibiting viral replication dependent on El and E2 of HPV11/HPV6 in these cell tests by co-transfecting, in human cell lines derived from kidney epithelial or cervical carcinoma cells, the replicon-reporter vector and pairs of HPV11/HPV6 El and E2 expression vectors. Various doses of the compounds were incubated for 2-6 days after transfection in the cell medium and luciferase activity was determined by means of a luminometer in order to evaluate IC50 of the compounds on replication of the HPV genome. All the compounds shown in the examples above inhibit replication dependent on El and E2 of HPVII/HPV6 in cells with an IC50 less than 2 0 uM. The preferred compounds are those for which IC50 may be less than 750 nM, With complementary cell tests, it was possible to show that the compounds shown in the examples above inhibit HPVll and HPV6 E1/E2 interaction. CLAIMS 1. Compounds of formula (I): (I) as well as their stereoisomers, wherein Gi represents a bond or a saturated or unsaturated, branched or linear hydrocarbon chain comprising 1-4 carbon atoms, optionally substituted with one or two alkyl groups, preferably identical, • R represents hydrogen atom, an alkyl, haloalkyl group, or a pro-drug radical such as a carbamate, acetyl, dialkylaminomethyl or -CH2-0-C0-Alk, • G represents a bond or a saturated or unsaturated, linear or branched hydrocarbon chain comprising 1-4 carbon atoms, optionally substituted with one or two alkyl groups, preferably identical, • W represents an oxygen, sulfur atom or NH, Ri and R2 either identical or different, each represent a group selected from a hydrogen atom, a halogen atom, a hydroxy1, thio, alkoxy, haloalkoxy, alkylthio, haloalkylthio, amino, raonoalkylamino, dialkylamino, cycloalkyl, alkyl or haloalkyl group, R3 represents an acid group or a pro-drug radical of the acid function such as an ester, or else a bioisoster of the acid function such as a tetrazole, phosphonate, phosphonamide, sulfonate or sulfonamide, A represents an aryl, cycloalkyl, cycloalkenyl group or a heterocycle, each optionally substituted, and B represents an aryl group or a 6-membered heterocycle, each optionally substituted, as well as their pharmaceutically acceptable salts. 2. The compounds according to claim 1, characterized in that A is substituted with one or two groups, either identical or different, selected from: • a hydrogen atom, a halogen atom, • an alkoxy, alkylthio, haloalkoxy, haloalkylthio, hydroxyl, thio, cyano, amino, monoalkylamino, or dialkylamino group, • an -SOnR', -COR', -CO2R', -OCOR', -CONR'R", -NR'COR" or -NR'SOZR" group, wherein R' and R" each represent independently of each other an hydrogen atom, an alky, haloalkyl group, and n has the value 1 or 2, • an alkyl or haloalkyl group, the alkyl group being optionally substituted with a cyano, amino, monoalkylamino, dialkylamino or acylamino group, • an aryl, arylalkyl, -X-aryl, -X-arylalkyl or -Alk-X-aryl group wherein X represents -0-, -WH-, -N(Alk) ~, -N{C0CH3)-, -S-, -SO-, -SO2-, -CO- or -CON"H-, each substituted on the aryl portion with one or two substituents, either identical or different, selected from: a hydrogen atom or an halogen atom, an alkyl, haloalkyl, alkoxy, haloalkoxy, thio, alkylthio, haloalkylthio. hydroxy1, cyano, acyl, amino, monoalkylamino or dialkylamino, acid, ester, amide, mono- or di-alkylamide group, an -SOnR', -COR', -CO2R' , -OCOR' , CONR'R' ' , -NR'COR' ' or -NR'SO2R' ' group, wherein R' and R' ' each represent independently of each other a hydrogen atom, an alkyl, haloalkyl group and n has the value 1 or 2, • a heterocycle, -Alk-heterocycle, -X- heterocycle, -X-Alk-heterocycle, or -Alk-X- heterocycle group, wherein X represents -0-, -NH-, -N(Alk)-, -N(COCH3) -, -S- , -SO-, -SO2- , -CO-, or -CONH-, each optionally substituted on the heterocycle portion with one or two substituents either identical or different, selected from: a hydrogen atom or a halogen atom, an alkyl, haloalkyl, alkoxy, haloalkoxy, thio, alkylthio, haloalkylthio, hydroxyl, cyano, acyl, amino, monoalkylamino or dialkylamino, acid, ester, amide, mono- or di-alkylamide group, or -SOr,R' , -COR', -CO2R' , -OCOR', CONR'R', -NR'COR' or NR'SOsR' ' group, wherein R' and R' ' each represent independently of each other a hydrogen atom, an alkyl, haloalkyl group and n has the value 1 or 2, • a cycloalkyl, -Alk-cycloalkyl, cycloalkenyl, -Alk-cycloalkenyl, -X-cycloalkyl, -X-Alk- cycloalkyl, -X-cycloalkenyl, -X-Alk- cycloalkenyl, -Alk-X-cycloalkyl, -Alk-X- cycloalkenyl group, wherein X represents -0-, -NH-, -N(Alk)-, -N(C0CH3)-, -S-, -SO-, -SO2-, -CO- or -CONH- each optionally substituted on the cyclic portion with one or two substituents, either identical or different, selected from: ^ a hydrogen atom or a halogen atom, v^ an alkyl, haloalkyl, alkoxy, haloalkoxy, thio, alkylthio, haloalkylthio, hydroxyl, cyano, acyl, amino, monoalkylamino or dialkylaraino, acid, ester, amide, mono- or di-alkylamide, or 0x0 or -SOnR' , -COR', -CO2R' , -OCOR' , CONR'R', -NR'COR' or NR'SOaR' group, wherein R' and R' ' each represent independently of each other a hydrogen atorri; an alkyl, haloalkyl group and n has the value 1 or 2, and Gi, G2, Ri, R2, ^3 and B are as defined in claim 1. 3. Compounds according to claim 1 or 2, characterized in that B is an aryl or 6-merabered heterocycle, substituted in the ortho position with a R4 group and optionally substituted with a R5group, wherein: • R4 represents: an alkyl, -NHAlk, -NAlkAlk' , -NHcycloalkyl or -NAlkcydloalkyl group, Alk and Alk' being identical or different, a cycloalkyl, cycloalkenyl, N-cycloalkyl or N-cycloalkenyl group, each optionally substituted with one or two substituents, either identical or different, selected from a hydrogen atom, a halogen atom, an alkyl, haloalkyl, alkoxy, haloalkoxy, thio. alkylthio, haloalkylthio, hydroxyl, cyano, acyl, amino, monoalkylamino or dialkylamino, acid, ester, amide, mono- or dialkylamide, oxo or -X-aryl group and wherein X represents -0-, -NH-, -N(Alk)-, -NiCOCKj)-, -S-, -SO-, -SOj-, -CO- or -CONH-, or *^ an aryl group optionally substituted with one or two substituents, either identical or different, an hydrogen atom, an halogen atom, an alkyl, haloalkyl, alkoxy, haloalkoxy, thio, alkylthio, h=iloalkylthio, hydroxyl, cyano, acyl, amino, monoalkylamino or dialkylamino, acid, ester, amide, mono or dialkylamide or -X-aryl group, wherein X represents -0-, -NH-, -N{Alk)-, -N(C0CH3)-, -S-, -SO-, -SO2-, -CO- or -CONH-, • R5 represei^ts: a hydrogen atom or a halogen atom, a hydroxyl, alkoxy, haloalkoxy, thio, alkylthio, haloalkylthio, amino, monoalkylamino, dialkylamino, -NHacyl, cyano, acyl, acid, ester, amide, monoalkylamide or dialkylamide group, an alkyl or haloalkyl group, the alkyl group may be substituted with a cyano, hydroxyl, alkoxy, acid or ester group, a -SOnAlk, -SOnNHa, -SOnNHAlk or SOnNAlkAlk' group, wherein n has the value of 1 or 2 and Alk and Alk' are either identical or different, or a piperidine, oxopiperidine, morpholine group, or else a piperazine group optionally substituted with an alkyl or acyl group. and Gi, G2, Ri, R2, R3 and A are as defined in claim 1 or 2 . 4. Compounds according to any of claims 1 to 3, characterized in that: Gi represents a bond or a saturated or unsaturated, linear or branched hydrocarbon chain comprising 1-4 carbon atoms, optionally substituted with one or two • R represents an hydrogen atom, an alkyl, haloalkyl group, or a pro-drug radical such as carbamate, acetyl, dialkylaminomethyl or -CH2-0-C0-Alk, • G represents a bond or a saturated or unsaturated, linear or branched, hydrocarbon chain comprising 1-4 carbon atoms, optionally substituted with one or two alkyl groups, preferably identical, and • W represents an oxygen, sulphur atom or NH, Ri and R2 either identical or different, each represent a group selected from a hydrogen atom, a halogen atom, a hydroxy1, thio, alkoxy, haloalkoxy, alkylthio, haloalkylthio, amino, monoalkylamino, dialkylamino, cycloalkyl, alkyl or haloalkyl group, R3 represents an acid group or a pro-drug radical of the acid function such as an ester, or else a bioisoster of the acid function such as tetrazole, phosphonate, phosphonamide, sulfonate or sulfonamide, A represents an aryl or heterocycle group, each optionally substituted with one or two groups, either identical or different, selected from: • a hydrogen atom, a halogen atom. • an alkoxy, alkylthio, haloalkoxy, haloalkylthio, hydroxyl, thio, cyano, amino, monoaIky1amino or dialkylamino group, • a -SOnR' , -COR'-, -CO2R' , -OCOR' , -CONR'R' ' , -NR'COR' ' or -NR'S02R' ' group, wherein R' and R' each represent independently of each other an hydrogen atom, an alkyl, haloalkyl group, and n has the value 1 or 2, • an alkyl or haloalkyl group, the alkyl group being optionally substituted with a cyano, amino, monoaIkylamino, dialkylamino or acylamino group, • an aryl, arylalkyl, -X-aryl group, wherein X represents -0-, -NH-, -N(Alk>-, -N(C0CH3)-, -S-, -SO-, -SO2-, -CO- or -CONH- group, each substituted on the aryl portion with one or two substituents, either identical or different, selected from: an hydrogen atom or an halogen atom, an alkyl, haloalkyl, alkoxy, haloalkoxy, thio, alkylthio, haloalkylthio, hydroxyl, cyano, acyl, amino, monoaIkylamino or di-alkylamino, acid, ester, amide, mono- or dialkylaraide group, or a -SOnR', -COR', -CO2R' , -OCOR', CONR' R' ' , -NR' COR' ' or -NR' SO2R' ' group, wherein R' and R' ' each represent independently of each other an hydrogen atom, an alkyl, haloalkyl group, and n has the value 1 or 2, • a heterocycle, -X-heterecycle group wherein X represents -0-, -NH-, -N(Alk)-, -N{C0CH3}-, -S-, -SO-, -SO2-, -CO- or -CONH-, each optionally substituted on the heterocycle portion with one or two substituents, either identical or different, selected from: a hydrogen atom or a halogen atom, an alkyl, haloalkyl, alkoxy, haloalkoxy, thio, alkylthio, haloalkylthio, hydroxyl, cyano, acyl, ainino, monoalkylamino or dialkylamino, acid, ester, amide, mono- or di-alkylamide group, or an -SOnR' , -COR', -CO2R' , -OCOR', COWR'R', -NR'COR' nr -NR'SOjR' ' group, wherein R' and R' ' each represent independently of each other a hydrogen atom, an alkyl, haloalkyl group, and n has the value 1 or 2, or • a cycloalkyl, cycloalkenyl, -X-cycloalkyl, -x-cycloalkenyl group wherein X represents -0-, NH-, -N(Alk)-, -NICOCH,)-, -S-, -SO-, -SO2-, -CO- or -CONH- group, each opt ionally substituted on the cycl'i-C portion with one or two substituents, either identical or different, selected from: a hydrogen atom or a halogen atom, an alkyl, haloalkyl, alkoxy, haloalkoxy, thio, alkylthio, haloalkylthio, hydroxyl, cyano, acy1, amino, monoalkylamino or dialkylamino, acid, ester, amide, mono- or di-alkylamide, or 0x0 group, or an -SOnR', -COR', -COaR' , -OCOR', CONR'R', -NR'COR' or -HR'SO^R' giroup, wherein R' and R' ' each represent independently of each other a hydtogen atom, an alkyl, haloalkyl group, and n has the value 1 or 2, and B represents a phenyl or pyridine group: substituted in the ortho position with an N-cycloalkyl group such as piperidine or with a cyclohexyl, each optionally substituted with one or two substituents, either identical or different, selected from a hydrogen atom, an alkyl, haloalkyl, alkoxy, haloalkoxy, -X-aryl group, where X represents -0-, -NH-, -N(Alk)-, N {COCH3) - , -S- , -SO- , -SO2- , -CO- or -CONH- , and/or optionally substituted with a halogen atom or with an alkyl or haloalkyl group. 5 . Compounds according to any of claims 1 to 4, characterized in that: Gi represents a bond or a saturated or unsaturated, linear or branched hydrocarbon chain comprising 1-4 carbon atoms, optionally substituted with one or two alkyl groups, preferably identical, preferably a bond or a hydrocarbon chain comprising 1 wherein n is an integer comprised between 1 and 4 and m is an integer having the value 1 or 2, preferably n has the value 1 or 2, Ri represents an alkoxy group, such as methoxy, preferably in the ortho position relatively to R.^, R2 represents a hydrogen or halogen atom, such as chlorine or bromine, or an alkyl group, such as methyl, preferably in the meta position relatively to R3, R3 represents an acid or ester group, A represents an aryl group such as a phenyl, preferably substituted: - in the meta or para position with; • a halogen atom or an alkyl, haloalkyl, cyano, alkoxy, haloalkoxy, acylaminoalkyl group or an -XR group, wherein X represents -0-, -NH-, -N(Alk)-, -N{C0CH3) -, -S-, -SO-, -SO2-, -CO-or -CONH- group, and R represents an arylalkyl, cycloalkyl or aryl group, each optionally substituted with one or two substituents, either identical or different, such as a halogen atom, an alkoxy, alkyl, haloalkyl, cyano, acyl, amino, monoalkylamino or dialkylamino, acid, ester, amide, mono- or di-alkylamide group, or a -SOnR' , -OCOR', -NR'COR' or -NR'S02' group, wherein R' and R" each represent independently of each other a hydrogen atom, an alkyl, haloalkyl group, and n has the value 1 or 2, • a cycloalkyl, aryl, arylalkyl group or heterocycle, preferably N-cycloalkyl, each being optionally substituted with one or two substituents, either identical or different, such as a halogen atom, an alkoxy, alkyl, haloalkyl, cyano, acyl, amino, monoalkylamino or dialkylamino, acid, ester, amide, mono- or di-alkylamide group, or a -SOi^R' , -OCOR' , -NR'COR', or -NR'SOsR' group, wherein R' and R' each represent independently of each other a hydrogen atom, an alkyl, haloalkyl group and n has the value 1 or 2, - and/or in the ortho or met a position with an alkyl group, and B represents an aryl group, preferably a phenyl, • substituted in the ortho position with a heterocycle, preferably a N-cycloalkyl, such as a piperidine group, and/or • substituted in the ortho' position with an alkyl group, such as a methyl. 6. Compounds according to any of claims 1 to 5, characterized in that: Gi represents a bond or a saturated or unsaturated, linear or branched hydrocarbon chain comprising 1-4 carbon atoms, optionally substituted with one or two alkyl groups, preferably identical, preferably a bond or a hydrocarbon chain comprising 1 wherein n is an integer comprised between 1 and 4 and m is an integer having the value 1 or 2, preferably n has the value 1 or 2, Ri represents an alkoxy group, such as methoxy, preferably in the ortho position relatively to R^, R2 represents a hydrogen or halogen atom, such as chlorine or bromine, or an alkyl group, such as methyl, preferably in the meta position relatively to R3, R3 represents an acid or ester group, A represents an aryl group such as a phenyl, preferably substituted: - in the meta or para position with: • a halogen atom or a cyano, alkoxy, haloalkoxy, acylaminoalkyl or -XR group, wherein X represents -0-, -S-, -SO-, -SO2-, or -CO- and R represents an arylalkyl, cycloalkyl or aryl group, each optionally substituted with one or two substituents, either identical or different, such as a halogen atom, an alkoxy or acyl group, or • a cycloalkyl, aryl or arlyalkyl group, each optionally substituted with one or two substituents, either identical or different, such as an acyl or alkoxy group, and - and/or in the ortho or meta position with an alkyl group, and B represents an aryl group, preferably a phenyl, • substituted in the ortho position with a heterocycle, preferably a N-cycloalkyl, such as a piperidine group, and/or • substituted in the ortho' position with an ^Ikyl group, such as a methyl. 6 . Compounds according to any of claims 1 to 6, selected from the following group; 1) 5-bromo-2-methoxy-4-[N- (4-methoxy-phenyl)-N-{2-piperidin-1-yl-phenyl)-hydrazinocarbonylmethyl]-benzoic acid hydrochloride 2) 5-bromo-2-methoxy~4-[N-(2-piperidin-1-yl-phenyl)-N-{4-trifluoromethoxy-phenyl)-hydrazinocarbonylmethyl]- benzoic acid hydrochloride 3} 5-bromo-2-methoxy-4-[N-(3-methoxy-benzyl)-N-(2-piperidin-1-yl-phenyl)-hydrazinocarbonylmethyl]-benzoic acid hydrochloride 4) 4-[N-(4-benzyloxy-phenyl)-N-(2-piperidin-l-yl-phenyl)-hydrazinocarbonylmethyl]-5-bromo-2-methoxy-benzoic acid hydrochloride 5) 5-bromo-4-(N-[4-(4-fluoro-phenoxy)-phenyl]-N-(2-piperidin-1-yl-phenyl)-hydrazinocarbonylmethyl}-2-methoxy-benzoic acid hydrochloride 6) 5-bromo-2-methoxy-4-{N-[2-(4-methoxy-phenyl)-ethyl]-N-2-piperidin-l-yl-phenyl)-hydrazinocarbonylmethyl}-benzoic acid hydrochloride 7) 5-bromo-2-methoxy-4-[N-(4-methoxy-phenyl)-N-(2-methyl-6-piperidin-l-yl-phenyl)-hydrazinocarbonyl¬methyl] -benzoic acid hydrochloride 7a) Methyl 5-bromo-2-Tnethoxy-4- [N- (4-methoxy-phenyl) -N-(2-methyl-6-piperidin-1-yl-phenyl)-hydrazinocarbonyl-methyl]-benzoate 8) 5-bromo-2-methoxy-4-[N-(4-methoxy-benzyl)-N-(2-piperidin-1-yl-phenyl}-hydrazinocarbonylmethyl]-benzoic acid hydrochloride 9) 5-bromo-4-[N-(4-cyclohexyl-phenyl)-N-(2-piperidin-l-yl-phenyl)-hydrazinocarbonylmethyl]-2-methoxy-benzoic acid hydrochloride 10) 5-bromo-2-raethoxy-4-[N-(2-methyl-6-piperidin-l-yl-phenyl) -N- (4-trif I'.ioromethoxy-phenyl) -hydrazino¬carbonylmethyl] -benzoic acid hydrochloride 11) 5-bromo-2-raethoxy-4-[N-(4'-methoxy-biphenyl-4-yl)-N-{2-piperidin-l-yl-phenyl)-hydrazinocarbonylmethyl]-benzoic acid hydrochloride 12) 5-bromo-4-[N-(4-cyclohexyloxy-phenyl)-N-(2-piperidin-1-yl-phenyl)-hydrazinocarbonylmethyl]-2-methoxy-benzoic acid hydrochloride 13) 5-bromo-2-methoxy-4-[N-(4-phenoxy-phenyl)-N-(2-piperidin-1-yl-phenyl)-hydrazinocarbonylmethyl]-benzoic acid hydrochloride 14) 5-bromo-4-{N-[4-{4-chloro-phenoxy)-phenyl]-N-(2-piperidin-1-yl-phenyl)-hydrazinocarbonylmethyl}-2-methoxy-benzoic acid hydrochloride 15) 4-{N-[4-(4-fluoro-phenoxy)-phenyl]-N-(2-methy1-6-piperidin-1-yl-phenyl)-hydrazinocarbonylmethyl}-2-methoxy-benzoic acid hydrochloride 16) 5-bromo-4-{N-[4-f4-fluoro-phenoxy)-phenyl]-N-{2-methyl-6-piperidin-l-yl-phenyl)-hydrazino-carbonyl-methyl}-2-methoxy-benzoic acid hydrochloride 16a) Methyl 5-bromo-4-{N-[4-(4~fluoro-phenoxy)-phenyl]-N-(2-methyl-6-piperidin-1-yl-phenyl)-hydrazino-carbonyl-methyl}-2-methoxy-benzoate 17) 4-[N-(4-benzyl-phenyl)-N-(2-piperidin-l-yl-phenyl) hydrazinocarbonylmethyl] -5-broino-2-methoxy-benzoic acid hydrochloride 18) 4- [N-(4-bromo-phenyl)-N-(2-piperidin-1-yl-phenyl) hydrazinocarbonylmethyl]-5-chloro-2~methoxy-benzoid acid hydrochloride 19} 4-[N-{3'-acetyl-biphenyl-4-yl)-N-(2-piperidin-l-yl- phenyl)-hydrazinocarbonylmethyl]-5-chloro-2-methoxy- benzoic acid hydrochloride 20) 4-[N-{4'-acetyl-biphenyl-4-yl)-N-(2-piperidin-l-yl-phenyl)-hydrazinocarbonylmethyl]-5-chloro-2-methoxy-benzoic acid hydrochloride 21) 5-bromo-2-methoxy-4-[N-(3-phenoxy)-phenyl]-N-(2 piperidin-1-yl-phenyl)-hydrazinocarbonylmethyl]-benzoic acid hydrochloride 22) 5-bromo-2-methoxy-4-[N-(4-phenylsulfanyl)-phenyl]-N-(2-piperidin-1-yl-phenyl)-hydrazinocarbonylmethyl]-benzoic acid hydrochloride 23) 4- [N-(4-benzenesulfonyl-phenyl)-N-(2-piperidin-1-yl-phenyl)-hydrazinocarbonylmethyl]-5-bromo-2-methoxy -benzoic acid hydrochloride 24) 4- [N-(4-benzenesulfinyl-phenyl)-N-(2-piperidin-l-yl-phenyl)-hydrazinocarbonylmethyl]-5-bromo-2-methoxy-benzoic acid hydrochloride 25) 2-methoxy-4-{{E)-2-[H-(4-methoxy-phenyl)-N-(2-methyl-6-piperidin-l-yl-phenyl)-hydrazinocarbonyl]-vinyl}-benzoic acid hydrochloride 26) 5-bromo-2-methoxy-4-{(E)-2-[N-(4-methoxy-phenyl)-N-(2-methyl-6-piperidin-l-yl-phenyl)-hydrazinocarbonyl]- vinyl}-benzoic acid hydrochloride 27) 4- [N-(4-benzyl-phenyl]-N-(2-methyl-6-piperidin~l-yl-phenyl)-hydrazinocarbonylmethyl]-5-bromo-2-methoxy-benzoic acid hydrochloride 28) 5-bromo-2-methoxy-4- [N- (4 ' -inethoxy-biphenyl-4-yl) -N-(2-methyl-6-piperidin-l-yl-phenyl)-hydrazino¬carbonyl -methyl] -benzoic acid hydrochloride 29) 4-[N-{acetylamino-methyl)-phenyl]-N-(2-methyl-6-piperidin-1-yl-phenyl}-hydrazinocarbonylmethyl]-5-bromo-2-inethoxy-benzoic acid hydrochloride 30) 4- [N-(4-benzoyl)-phenyl]-N-(2-piperidin-l-yl-phenyl}-hydrazinocarbonylmethyl]-5-bromo-2-methoxy-benzoic acid hydrochloride 31) 5-bromo-4-[N-{4-cyano-phenyl)-N-(2-methyl-6-piperidin-1-yl-phenyl)-hydrazinocarbonylmethyl]-2-methoxy-benzoic acid hydrochloride 32) 4- [N-(4'-acetyl-biphenyl-4-yl)-N-(2-methyl-6-piperidin-1-yl-phenyl)-hydrazinocarbonylmethyl]-5-bromo-2-methoxy-benzoic acid hydrochloride 33) 5-bromo-2-methoxy-4-[N-(4'-methoxy-2-methyl-biphenyl-4-yl)-N-(2-methyl-6-piperidin~l-yl-phenyl)-hydrazinocarbonylmethyl]-benzoic acid hydrochloride - 8. Intermediates for the synthesis of compounds according to claim 7 selected from the following group: a) N-(4-methoxy-phenyl)-N-(2-piperidin~l-yl-phenyl)-hydrazine b) N-(2-piperidin-l-yl-phenyl)-N-(4-trifluoromethoxy-phenyl)-hydrazine c) N-(3-methoxy-benzyl)-N-(2-piperidin-l-yl-phenyl)-hydrazine d) N-(4-benzyloxy-phenyl)-N-(2-piperidin-l-yl-phenyl)-hydrazine e) N- [4-(4-fluoro-phenoxy)-phenyl]-W-(2-piperidin-l-yl-phenyl) -hydrazine f) N- [2-(4-methoxy-phenyl)-ethyl]-N-(2-piperidin-l-yl-phenyl )-hydrazine g) N-(4-methoxy-phenyl)-N-(2-methyl-6-piperidin-1-yl-pheny1)-hydra z ine h) N-(4-methoxy-benzyl)-N-(2-piperidin-l-yl-phenyl)-hydrazine i) N-{4-cyclohexyl-phenyl)-N-{2-piperidin-1-yl-phenyl)-hydrazine j) N-{2-methyl-6-piperidin-l-yl-phenyl)~N-(4-trifluoro-methoxy-phenyl)-hydrazine k) N-(4'-methoxy-biphenyl-4-yl)-N-(2-piperidin-l-yl-phenyl)-hydrazine 1) N-{4-cyclohexyloxy-phenyl)-N-(2-piperidin-l-yl-phenyl)-hydrazine m) N-(4-phenoxy-phenyl)-N-(2-piperidin-1-yl-phenyl)-hydrazine n) N- [4- (4-chloro-pher,cxy} -phenyl] -N- (2-piperidin-l-yl-phenyl)-hydrazine o) N-[4-(4-fluoro-phenoxy)-phenyl]-N-(2-methyl-6-piperidin-1-yl-phenyl)-hydrazine p) N-{4-benzyl-phenyl]-N-(2-piperidin-l-yl-phenyl)-hydrazine q) K-{4-bromo-phenyl)-N-(2-piperidin-l-yl-phenyl)-hydrazine r) W-(3-phenoxy-phenyl)-N-(2-piperidin-l-yl-phenyl)-hydrazine s) N-{4-phenylsulfany1-phenyl)-N-(2-piperidin-l-yl-phenyl )-hydra z ine t) N-(4-benzyl-phenyl)-N-(2-methyl-6-piperidin-l-yl-phenyl)-hydrazine u) N-(4'-methoxy-biphenyl-4-yl)-N-(2-methyl-6-piperidin-1-yl-phenyl)-hydrazine v) N-(4-benzoyl-phenyl)-N-(2-piperidin-l-yl-phenyl)-hydrazine w) N- [4'-(2-methyl-[1,3]dithian-2-yl)-biphenyl-4-yl]-N-(2-methyl-6-piperidin-1-yl-phenyl)-hydrazine x) N-(4'-methoxy-2-methyl-bipheny1-4-yl)-N-[2-methyl-6-piperidin-1-yl-phenyl)hydrazine. 9. A method for preparing compounds of formula (I) according to any of claims 1 to 7, wherein wherein W represents an oxygen atom and R3 is as defined earlier, 3) If necessary, reaction of the compound of foi'mula (I) obtained in step 2) or else of the compound of formula {IV) obtained in step 1) with a Lawesson reagent, so that a compound of formula (I) may be obtained, wherein W represents a sulphur atom. 2) Deprotection of the -CO2P group of the compound of formula {IV) by hydrolysis in order to obtain the 11. A pharmaceutical composition comprising at least one compound of formula (I) according to any of claims 1 to 7, in association with a pharmaceutically acceptable excipient. 12. A compound of formula (I) according to any of claims 1 to 7, for its use as a drug. 13. A use of a compound of formula (I) according to any of claims 1 to 7, for preparing a drug intended for treating or preventing an infection by the papilloma virus, 14. The use according to claim 13, for treating or preventing lesions and diseases associated with infections by the papilloma virus. 15. The use according to claim 13 or 14, for treating or preventing ano-genital warts, such as acuminated condylomas and plane condylomas, laryngeal, conjunctive or buccal papillomas or other epithelial lesions such as recurrent respiratory papillomatoses and low grade and high grade intra-epithelial neoplasias, bowenoid papuloses, warts (verruca vulgaris, verruca plantaris, myrmecia wart, surface wart, verruca plana...) , epidermodysplasia verruciformis, carcinomas, in particular ano-genital carcinomas, and all lesions associated with the papilloma virus. |
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| Patent Number | 269394 | ||||||||||||
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| Indian Patent Application Number | 6249/CHENP/2008 | ||||||||||||
| PG Journal Number | 44/2015 | ||||||||||||
| Publication Date | 30-Oct-2015 | ||||||||||||
| Grant Date | 19-Oct-2015 | ||||||||||||
| Date of Filing | 17-Nov-2008 | ||||||||||||
| Name of Patentee | ANACONDA PHARMA | ||||||||||||
| Applicant Address | 11, RUE WATT-75013 PARIS | ||||||||||||
Inventors:
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| PCT International Classification Number | C07D295/12 | ||||||||||||
| PCT International Application Number | PCT/EP2007/054843 | ||||||||||||
| PCT International Filing date | 2007-05-18 | ||||||||||||
PCT Conventions:
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