Title of Invention	"A PHARMACEUTICAL COMBINATION OF PYRAZOLE COMPOUNDS AND ANCILLARY AGENTS"
Abstract	The invention provides a combination of an ancillary agent and a compound having the formula (0): or salts or tautomers or N-oxides or solvates thereof; wherein the ancillary agent is selected from: a monoclonal antibody, an alkylating agent an anticancer agent, a further CDK inhibitor and a hormone, hormone agonist, hormone antagonist or hormone modulating agent; X is a group R1-A-NR4- or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C=0, NR0(C=O) or 0(C=0) wherein R° is hydrogen or C-M hydrocarbyl optionally substituted by hydroxy or C-M alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from halogen (e.g. fluorine), hydroxy, C1-4 hydrocarbyloxy, amino, mono- or di-C1-4 hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO2; R2 is hydrogen; halogen; C1-4 alkoxy (e.g. methoxy); or a C1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4 alkoxy (e.g. methoxy); R3 is selected from hydrogen and carbocyclic and heterocyclic groups having from 3 to 12 ring members; and R4 is hydrogen or a C1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4 alkoxy (e.g. methoxy).

Title of Invention

"A PHARMACEUTICAL COMBINATION OF PYRAZOLE COMPOUNDS AND ANCILLARY AGENTS"

Abstract

The invention provides a combination of an ancillary agent and a compound having the formula (0): or salts or tautomers or N-oxides or solvates thereof; wherein the ancillary agent is selected from: a monoclonal antibody, an alkylating agent an anticancer agent, a further CDK inhibitor and a hormone, hormone agonist, hormone antagonist or hormone modulating agent; X is a group R1-A-NR4- or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C=0, NR0(C=O) or 0(C=0) wherein R° is hydrogen or C-M hydrocarbyl optionally substituted by hydroxy or C-M alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from halogen (e.g. fluorine), hydroxy, C1-4 hydrocarbyloxy, amino, mono- or di-C1-4 hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO2; R2 is hydrogen; halogen; C1-4 alkoxy (e.g. methoxy); or a C1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4 alkoxy (e.g. methoxy); R3 is selected from hydrogen and carbocyclic and heterocyclic groups having from 3 to 12 ring members; and R4 is hydrogen or a C1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4 alkoxy (e.g. methoxy).

Full Text	ATTACHED

Documents:

http://ipindiaonline.gov.in/patentsearch/GrantedSearch/viewdoc.aspx?id=6yA3dZwiOQc9LnyNZ3t0Hw==&loc=egcICQiyoj82NGgGrC5ChA==

« Previous Patent

Next Patent »

Patent Number

269704

Indian Patent Application Number

3649/CHENP/2007

PG Journal Number

45/2015

Publication Date

06-Nov-2015

Grant Date

02-Nov-2015

Date of Filing

21-Aug-2007

Name of Patentee

ASTEX THERAPEUTICS LIMITED

Applicant Address

436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA

Inventors:

#	Inventor's Name	Inventor's Address
1	CURRY, Jayne, Elizabeth	436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA
2	LYONS, John, Francis	436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA
3	SQUIRES, Matthew, Simon	436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA
4	THOMPSON, Neil, Thomas	436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA
5	THOMPSON, Kyla, Merriom	Suite 7, Innovation Centre, 23 Cambridge Science Park, Milton Road, Cambridge CB4 0EY
6	WYATT, Paul, Graham	Division of Biological & Molecular Microbiology, University of Dundee, Dow Street, Dundee DD1 5EH

PCT International Classification Number

A61K 31/415

PCT International Application Number

PCT/GB2006/000210

PCT International Filing date

2006-01-20

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1	60/646,216	2005-01-21	U.S.A.
2	60/645,974	2005-01-21	U.S.A.
3	60/646,003	2005-01-21	U.S.A.
4	60/645,988	2005-01-21	U.S.A.
5	60/646,001	2005-01-21	U.S.A.