Indian Patents. 270177:BENZOIMIDAZOLE-2-YL PYRIMIDINES AND PYRAZINES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR

Title of Invention	BENZOIMIDAZOLE-2-YL PYRIMIDINES AND PYRAZINES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR
Abstract	Benzoimidazol-2-yl pyrimidines, pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritis.

Full Text	BENZOIMIDAZOL-2-YL PYRIMIDINES AND PYRAZINES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR Field of the Invention The present invention relates to certain benzoimidazol-2-yl pyrimidines and pyrazines, pharmaceutical compositions containing them, and methods of using them for the treatment of disease states, disorders, and conditions mediated by histamine H4 receptor activity. Background of the Invention The histamine H4 receptor (H4R) is the most recently identified receptor for histamine (for reviews, see: Fung-Leung, W.-P., et al., Curr. Opin. Invest. Drugs 2004, 5(11), 1174-1183; de Esch, UP., etai., Trends Pharmacol. Sci. 2005, 26(9), 462-469). The receptor is found in the bone marrow and spleen and is expressed on eosinophils, basophils, mast cells (Liu, C, et al., Mol. Pharmacol. 2001,59(3), 420-426; Morse, K.L., et al., J. Pharmacol. Exp. Ther. 2001, 296(3), 1058-1066; Hofstra, C.L., et al., J.'Pharmacol. Exp. Ther. 2003. 305(3), 1212- 1221; Lippert, U., et al., J. Invest. Dermatol. 2004,123(1), 116-123; Voehringer, D., et al., Immunity 2004, 20(3), 267-277), CD8+ T cells (Gantner, F., et al., J. Pharmacol. Exp. Ther. 2002, 303(1), 300-307), dendritic cells, and human synovial cells from rheumatoid arthritis patients (Ikawa, Y., et al., Biol. Pharm. Bull. 2005,28(10), 2016-2018). However, expression in neutrophils and monocytes is less well defined (Ling, P., et al., Br. J. Pharmacol. 2004,142(1), 161-171). Receptor expression is at least in part controlled by various inflammatory stimuli (Coge, F., et al., Biochem. Biophys. Res. Commun. 2001, 284(2), 301-309; Morse, et al., 2001), thus supporting that H4 receptor activation influences inflammatory responses. Because of its preferential expression on immunocompetent cells, the H4 receptor is closely related with the regulatory functions of histamine during the immune response. A biological activity of histamine in the context of immunology and autoimmune diseases is closely related with the allergic response and its deleterious effects, such as inflammation. Events that elicit the inflammatory response include physical stimulation (including trauma), chemical stimulation, infection, and invasion by a foreign body. The inflammatory response is characterized by pain, increased temperature, redness, swelling, reduced function, or a combination of these. Mast cell degranulation (exocytosis) releases histamine and leads to an inflammatory response that may be initially characterized by a histamine- modulated wheal and flare reaction. A wide variety of immunological stimuli (e.g., allergens or antibodies) and non-immunological (e.g., chemical) stimuli may cause the activation, recruitment, and de-granulation of mast cells. Mast cell activation initiates allergic inflammatory responses, which in tμm cause the recruitment of other effector cells that further contribute to the inflammatory response. It has been shown that histamine induces chemotaxis of mouse mast cells (Hofstra, et al., 2003). Chemotaxis does not occur using mast cells derived from H4 receptor knockout mice. Furthermore, the response is blocked by an H4- specific antagonist, but not by H1, H2 or H3 receptor antagonists (Hofstra, et al., 2003; Thurmond, R.L., et al., J. Pharmacol. Exp. Ther. 2004, 309(1), 404-413). The in vivo migration of mast cells to histamine has also been investigated and shown to be H4 receptor dependent (Thurmond, et aj., 2004). The migration of mast cells may play a role in allergic rhinitis and allergy where increases in mast cell number are found (Kirby, J.G., et al., Am. Rev. Respir. Dis. 1987, 136(2), 379-383; Crimi, E., et al., Am. Rev. Respir. Dis. 1991, 144(6), 1282-1286; Amin, K., et al., Am. J. Resp. Crit. Care Med. 2000,162(6), 2295-2301; Gauvreau, G.M., et al., Am. J. Resp. Crit. Care Med. 2000,161(5), 1473-1478; Kassel, O., et al., Clin. Exp. Allergy 2001, 31(9), 1432-1440). In addition, it is known that in response to allergens there is a redistribution of mast cells to the epithelial lining of the nasal mucosa (Fokkens, W.J., et al., Clin. Exp. Allergy 1992, 22(7), 701- 710; Slater, A., et al., J. Laryngol. Otol. 1996,110, 929-933). These results show that the chemotactic response of mast cells is mediated by histamine H4 receptors. It has been shown that eosinophils can chemotax towards histamine (O'Reilly, M., et al., J. Recept. Signal Transduction 2002, 22(1-4), 431-448; Buckland, K.F., et al.. Br. J. Pharmacol. 2003,140(6), 1117-1127; Ling et al., 2004). Using H4 selective ligands, it has been shown that histamine-induced chemotaxis of eosinophils is mediated through the H4 receptor (Buckland, et al., 2003; Ling et al., 2004). Cell surface expression of adhesion molecules CD11b/CD18 (LFA-1) and CD54 (ICAM-1) on eosinophils increases after histamine treatment (Ling, et al., 2004). This increase is blocked by H4 receptor antagonists but not by H1, H2, or H3 receptor antagonists. The H4R also plays a role in dendritic cells and T cells. In human monocyte-derived dendritic cells, H4R stimulation suppresses IL-12p70 production and drives histamine-mediated chemotaxis (Gutzmer, R., et al., J. Immunol. 2005, 174(9), 5224-5232). A role for the H4 receptor in CD8+ T cells has also been reported. Gantner, et al., (2002) showed that both H4 and H2 receptors control histamine-induced IL-16 release from human CD8+ T cells. IL-16 is found in the bronchoalveolar fluid of allergen- or histamine-challenged asthmatics (Mashikian, V.M., et al., J. Allergy Clin. Immunol. 1998,101 (6, Part 1), 786-792; Krug, N., et al., Am. J. Resp. Crit Care Med. 2000,162(1), 105-111) and is considered important in CD4+ cell migration. The activity of the receptor in these cell types indicates an important role in adaptive immune responses such as those active in autoimmune diseases. In vivo H4 receptor antagonists were able to block neutrophillia in zymosan- induced peritonitis or pleurisy models (Takeshita, K., et al., J. Pharmacol. Exp. Ther. 2003, 307(3), 1072-1078; Thurmond, et al., 2004). In addition, H4 receptor antagonists have activity in a widely used and well-characterized model of colitis (Varga, C, et al., Eur. J. Pharmacol. 2005, 522(1-3), 130-138). These results support the conclusion that H4 receptor antagonists have the capacity to be anti- inflammatory in vivo. Another physiological role of histamine is as a mediator of itch and H1 receptor antagonists are not completely effective in the clinic. Recently, the H4 receptor has also been implicated in histamine-induced scratching in mice (Bell, J.K., et al., Br. J. Pharmacol. 2004,142(2), 374-380). The effects of histamine could be blocked by H4 antagonists. These results support the hypothesis that the H4 receptor is involved in histamine-induced itch and that H4 receptor antagonists will therefore have positive effects in treating pruritis. Modulation of H4 receptors controls the release of inflammatory mediators and inhibits leukocyte recruitment, thus providing the ability to prevent and/or treat H4-mediated diseases and conditions, including the deleterious effects of allergic responses such as inflammation. Compounds according to the present invention have H4 receptor modulating properties. Compounds according to the present invention have leukocyte recruitment inhibiting properties. Compounds according to the present invention have anti-inflammatory properties. Examples of textbooks on the subject of inflammation include: 1) Gallin, J.I.; Snyderman, R., Inflammation: Basic Principles and Clinical Correlates, 3rd ed.; Lippincott Williams & Wilkins: Philadelphia, 1999; 2) Stvrtinova, V., et al., Inflammation and Fever. Pathophysiology Principles of Diseases (Textbook for Medical Students); Academic Press: New York, 1995; 3) Cecil; et al. Textbook Of Medicine, 18th ed.; W.B. Saunders Co., 1988; and 4) Stedman's Medical Dictionary. Background and review material on inflammation and conditions related with inflammation can be found in articles such as the following: Nathan, C, Nature 2002,420(6917), 846-852; Tracey, K.J., Nature 2002, 420(6917), 853- 859; Coussens, L.M., et al., Nature 2002,420(6917), 860-867; Libby, P., Nature 2002, 420, 868-874; Benoist, C, et al, Nature 2002,420(6917), 875-878; Weiner, H.L., et al., Nature 2002,420(6917), 879-884; Cohen, J., Nature 2002, 420(6917), 885-891; Steinberg, D., Nature Med. 2002, 8(11), 1211-1217. Thus, small-molecule histamine H4 receptor modulators according to this invention control the release of inflammatory mediators and inhibit leukocyte recruitment, and may be useful in treating inflammation of various etiologies, including the following conditions and diseases: inflammatory disorders, allergic disorders, dermatological disorders, autoimmune disease, lymphatic disorders, pruritis, and immunodeficiency disorders. Diseases, disorders and medical conditions that are mediated by histamine H4 receptor activity include those referred to herein. 2-Arylbenzimidazoles have been described as histamine H4 receptor modulators, see, for example, U.S. Pat. Appl. Publ. 2005/0070550A1. However, there still remains a need for potent histamine H4 receptor modulators with desirable pharmaceutical properties. Summary of the Invention Certain benzoimidazol-2-yl pyrimidines and pyrazines have now been found to have histamine H4 receptor-modulating activity. In one general aspect, the invention relates to compounds of the following Formula (I): wherein each of R1-4 is independently H, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, phenyl, -CF3, - OCF3, -CN, halo, -NO2, -OC1-4alkyl, -SC1-4alkyl, -S(O)C1-4alkyl, -S02C1-4alkyl, -C(O)C1-4alkyl, -C(O)phenyl, -C(O)NRaRb, -CO2C1-4alkyl, -CO2H, -C(O)NRaRb, or-NRaRb; wherein R8 and Rb are each independently H, C1-4alkyl, or C3-7cycloalkyl; one of X1 and X2 is N and the other is C-Rc; where Rc is H, methyl, hydroxymethyl, dimethytaminomethyl, ethyl, propyl, isopropyl, -CF3, cyclopropyl, or cyclobutyl; n is 1 or 2; Z is N, CH, or C(C1-4alkyl); R6 is H, C1-6alkyl, or monocyclic cycloalkyl; R8 is H or C1-4alkyl; R8 and R10 are each independently H or C1-4alkyl; and R11 is H or C1-4a!kyl. This invention also relates to any of the following: pharmaceutically acceptable salts of compounds of Formula (I), pharmaceutically acceptable prodrugs of compounds of Formula (I), and pharmaceutically active metabolites of compounds of Formula (I). In other embodiments, the compound of Formula (i) is a compound selected from those species described or exemplified in the detailed description below. In a further general aspect, the invention relates to pharmaceutical compositions each comprising: (a) an effective amount of at least one agent selected from compounds of Formula (I) and pharmaceutically acceptable salts, pharmaceutically acceptable prodrugs, and pharmaceutically active metabolites thereof; and (b) a pharmaceutically acceptable excipient. In another general aspect, the invention is directed to a method of treating a subject suffering from or diagnosed with a disease, disorder, or medical condition mediated by histamine H4 receptor activity, comprising administering to the subject in need of such treatment an effective amount of at least one compound of Formula (I), or a pharmaceutically acceptable salt, pharmaceutically acceptable prodrug, or pharmaceutically active metabolite of such compound. In certain preferred embodiments of the inventive method, the disease, disorder, or medical condition is inflammation. Inflammation herein refers to the response that develops as a consequence of histamine release, which in tμm is caused by at least one stimulus. Examples of such stimuli are immunological stimuli and non-immunoiogical stimuli. In another general aspect, the invention is directed to a method for modulating histamine H4 receptor activity, comprising exposing histamine H4 receptor to an effective amount of at least one of a compound of Formula (I) and a salt thereof. Additional embodiments, features, and advantages of the invention will be apparent from the following detailed description and through practice of the invention. Detailed Description of Invention The invention may be more fully appreciated by reference to the following description, including the following glossary of terms and the concluding examples. For the sake of brevity, the disclosures of the publications, including patents, cited in this specification are herein incorporated by reference. As used herein, the terms "including", "containing" and "comprising" are used herein in their open, non-limiting sense. The term "alkyl" refers to a straight- or branched-chain alkyl group having from 1 to 12 carbon atoms in the chain. Examples of alkyl groups include methyl (Me, which also may be structurally depicted by the symbol "I"), ethyl (Et), n- propyl, isopropyl, butyl, isobutyl, sec-butyl tert-butyl (tBu), pentyl, isopentyl, tert- pentyl, hexyl, isohexyl, and groups that in light of the ordinary skill in the art and the teachings provided herein would be considered equivalent to any one of the foregoing examples. The term "alkenyl" refers to a straight- or branched-chain alkenyl group having from 2 to 12 carbon atoms in the chain. (The double bond of the alkenyl group is formed by two sp2 hybridized carbon atoms.) Illustrative alkenyl groups include prop-2-enyl, but-2-enyl, but-3-enyl, 2-methylprop-2-enyl, hex-2-enyl, and groups that in light of the ordinary skill in the art and the teachings provided herein would be considered equivalent to any one of the foregoing examples. The term "cycloalkyl" refers to a saturated or partially saturated, monocyclic, fused polycyclic, or spiro polycyclic carbocycle having from 3 to 12 ring atoms per carbocycle. Illustrative examples of cycloalkyl groups include the following entities, in the form of properly bonded moieties: A "heterocycloalkyr refers to a monocyclic, or fused, bridged, or spiro polycyclic ring structure that is saturated or partially saturated and has from 3 to 12 ring atoms per ring structure selected from carbon atoms and up to three heteroatoms selected from nitrogen, oxygen, and sulfur. The ring structure may optionally contain up to two oxo groups on carbon or sulfur ring members. Illustrative entities, in the form of properly bonded moieties, include: The term "heteroaryl" refers to a monocyclic, fused tricyclic, or fused polycyclic aromatic heterocycle (ring structure having ring atoms selected from carbon atoms and up to four heteroatoms selected from nitrogen, oxygen, and sulfur) having from 3 to 12 ring atoms per heterocycle. Illustrative examples of heteroaryl groups include the following entities, in the form of properly bonded moieties: Those skilled in the art will recognize that the species of heteroaryl, cycloalkyl, and heterocycloalkyl groups listed or illustrated above are not exhaustive, and that additional species within the scope of these defined terms may also be selected. The term "halogen" represents chlorine, fluorine, bromine, or iodine. The term "halo" represents chloro, fluoro, bromo, or iodo. The term "substituted" means that trie specified group or moiety bears one or more substituents. The term "unsubstituted" means that the specified group bears no substituents. The term "optionally substituted" means that the specified group is unsubstituted or substituted by one or more substituents. Where the term "substituted" is used to describe a structural system, the substitution is meant to occur at any valency-allowed position on the system. Any formula given herein is intended to represent compounds having structures depicted by the structural formula as well as certain variations or forms. In particular, compounds of any formula given herein may have asymmetric centers and therefore exist in different enantiomeric forms. All optical isomers and stereoisomers of the compounds of the general formula, and mixtures thereof, are considered within the scope of the formula. Thus, any formula given herein is intended to represent a racemate, one or more enantiomeric forms, one or more diastereomeric forms, one or more atropisomeric forms, and mixtures thereof. Furthermore, certain structures may exist as geometric isomers (i.e., cis and trans isomers), as tautomers, or as atropisomers. Additionally, any formula given herein is intended to represent hydrates, solvates, and polymorphs of such compounds, and mixtures thereof. To provide a more concise description, some of the quantitative expressions given herein are not qualified with the term "about". It is understood that, whether the term "about" is used explicitly or not, every quantity given herein is meant to refer to the actual given value, and it is also meant to refer to the approximation to such given value that would reasonably be inferred based on the ordinary skill in the art, including equivalents and approximations due to the experimental and/or measurement conditions for such given value. Whenever a yield is given as a percentage, such yield refers to a mass of the entity for which the yield is given with respect to the maximum amount of the same entity that could be obtained under the particular stoichiometric conditions. Concentrations that are given as percentages refer to mass ratios, unless indicated differently. Reference to a chemical entity herein stands for a reference to any one of: (a) the actually recited form of such chemical entity, and (b) any of the forms of such chemical entity in the medium in which the compound is being considered when named. For example, reference herein to a compound such as R-COOH, encompasses reference to any one of, for example, R-COOH(8), R-COOH(sol), and R-COO"(sol). In this example, R-COOH(8) refers to the solid compound, as it could be for example in a tablet or some other solid pharmaceutical composition or preparation; R-COOH(sol) refers to the undissociated form of the compound in a solvent; and R-COO"(sol) refers to the dissociated form of the compound in a solvent, such as the dissociated form of the compound in an aqueous environment, whether such dissociated form derives from R-COOH, from a salt thereof, or from any other entity that yields R-COO" upon dissociation in the medium being considered. In another example, an expression such as "exposing an entity to compound of formula R-COOH" refers to the exposure of such entity to the form, or forms, of the compound R-COOH that exists, or exist, in the medium in which such exposure takes place. In this regard, if such entity is for example in an aqueous environment, it is understood that the compound R- COOH is in such same medium, and therefore the entity is being exposed to species such as R-COOH(aq) and/or R-COO"(aq), where the subscript "(aq)" stands for "aqueous" according to its conventional meaning in chemistry and biochemistry. A carboxylic acid functional group has been chosen in these nomenclature examples; this choice is not intended, however, as a limitation but it is merely an illustration. It is understood that analogous examples can be provided in terms of other functional groups, including but not limited to hydroxy!, basic nitrogen members, such as those in amines, and any other group that interacts or transforms according to known manners in the medium that contains the compound. Such interactions and transformations include, but are not limited to, dissociation, association, tautomerism, solvolysis, including hydrolysis, solvation, including hydration, protonation, and deprotonation. In another example, a zwitterionic compound is encompassed herein by referring to a compound that is known to form a zwitterions, even if it is not explicitly named in its zwitterionic form. Terms such as zwitterion, zwitterions, and their synonyms zwitterionic compound(s) are standard IIJPAC-endorsed names that are well known and part of standard sets of defined scientific names. In this regard, the name zwitterion is assigned the name identification CHEBI:27369 by the Chemical Entities of Biological Inerest (ChEBI) dictionary of molecular entities. (See, for example its on line version at http://www.ebi.ac.uk/chebi/init.do). As generally well known, a zwitterion or zwitterionic compound is a neutral compound that has formal unit charges of opposite sign. Sometimes these compounds are referred to by the term "inner salts". Other sources refer to these compounds as "dipolar ions", although the latter term is regarded by still other sources as a misnomer. As a specific example, aminoothanoic acid (the amino acid glycine) has the formula H2NCH2COOH, and It exists in some media (in this case in neutral media) in the form of the zwitterion +H3NCH2COO. Zwitterions, zwitterionic compounds, inner salts and dipolar ions in the known and well established meanings of these terms are within the scope of this invention, as would in any case be so appreciated by those of ordinary skill in the art. Because there is no need to name each and every embodiment that would be recognized by those of ordinary skill in the art, no structures of the zwitterionic compounds that are associated with the compounds of this invention are given explicitly herein. They are, however, part of the embadiments of this invention. No further examples in this regard are provided herein because these interactions and transformations in a given medium are known by any one of ordinary skill in the art. Any formula given herein is also intended to represent unlabeled forms as well as isotopically labeled forms of the compounds. Isotopically labeled compounds have structures depicted by the Formulas given herein except that one or more atoms are replaced by an atom having a selected atomic mass or mass number. Examples of isotopes that can be incorporated into compounds of the invention include isotopes of hydrogen, carbon, nitrogen, oxygen, phosphorous, fluorine, chlorine, and iodine, s uch as 2H, 3H, 11C, 13C, 14C, 15N, 18O, 17Q 31 p 32P, 35Sj 18F, 36Cl, 125l, respectively. Such isotopically labelled compounds are useful in metabolic studies (preferably with 14C), reaction kinetic studies (with, for example 2H or 3H), detection or imaging techniques [such as positron emission tomography (PET) or single-photon emission computed tomography (SPECT)] including drug or substrate tissue distribution assays, or in radioactive treatment of patients. In particular, an 18F or 11C labeled compound may be particularly preferred for PET or SPECT studies. Further, substitution with heavier isotopes such as deuterium (i.e., 2H) may afford certain therapeutic advantages resulting from greater metabolic stability, for example increased in vivo half-life or reduced dosage requirements. Isotopically labeled compounds of this invention and prodrugs thereof can generally be prepared by carrying out the procedures disclosed in the schemes or in the examples and preparations described below by substituting a readily Eivailable isotopically labeled reagent for a non-isotopically labeled reagent. When referring to any formula given herein, the selection of a particular moiety from a list of possible species for a specified variable is not intended to define the same choice of the species for the variable appearing elsewhere. In other words, where a variable appears more than once, the choice of the species from a specified list is independent of the choice of the species for the same variable elsewhere in the formula, unless stated otherwise. By way of a first example on substituent terminology, if substituent S1example is one of S1 and S2, and substituent S2example is one of S3 and S4, then these assignments refer to embodiments of this invention given according to the Choices S example is S1 and S example is S3; S1 example is S1 and S example iS S4; S1 example is S2 and S2example is S3; S1example is S2 and S2example is S4; and equivalents of each one of such choices. The shorter terminology "S1example is one of S1 and S2, and S2 example is one of S3 and S4" is accordingly used herein for the sake of brevity, but not by way of limitation. The foregoing first example on substituent terminology, which is stated in generic terms, is meant to illustrate the various substituent assignments described herein. The foregoing convention given herein for substituents extends, when applicable, to members such as R111, X1, X2, and n, and any other generic substituent symbol used herein. Furthermore, when more than one assignment is given for any member or substituent, embodiments of this invention comprise the various groupings that can be made from the listed assignments, taken independently, and equivalents thereof. By way of a second example on substituent terminology, if it is herein described that substituent Sexample is one of S1, S2, and S3, this listing refers to embodiments of this invention for which Sexample is S1; Sexample is S2; Sexample is S3; Sexample is one of S1 and S2; Sexample is one of S1 and S3; Sexample is one of S2 and S3; Sexample is one of S1, S2 and S3; and Sexample is any equivalent of each one of these choices. The shorter terminology "Sexample is one of S1, S2, and S3" is accordingly used herein for the sake of brevity, but not by way of limitation. The foregoing second example on substituent terminology, which is stated in generic terms, is meant to illustrate the various substituent assignments described herein. The foregoing convention given herein for substituents extends, when applicable, to members such as R1-11, X1, X2, and n, and any other generic substituent symbol used herein. The nomenclature "CH" with j > I, when applied herein to a class of substituents, is meant to refer to embodiments of this invention for which each and every one of the number of carbon members, from i to j including i and j, is independently realized. By way of example, the term C1.3 refers independently to embodiments that have one carbon member (C1), embodiments that have two carbon members (C2), and embodiments that have three carbon members (C3). The term Cn-malkyl refers to an aliphatic chain, whether straight or branched, with a total number N of carbon members in the chain that satisfies n ≤ N ≤ m, with m > n. Any disubstituent referred to herein is meant to encompass the various attachment possibilities when more than one of such possibilities are allowed. For example, reference to disubstituent -A-B-, where A ≠ B, refers herein to such disubstituent with A attached to a first substituted member and B attached to a second substituted member, and it also refers to such disubstituent with A attached to the second substituted member and B attached to the first substituted member. According to the foregoing interpretive considerations on assignments and nomenclature, it is understood that explicit reference herein to a set implies, where chemically meaningful and unless indicated otherwise, independent reference to embodiments of such set, and reference to each and every one of the possible embodiments of subsets of the set referred to explicitly. In some embodiments of Formula (I), each of R1-4 is independently H, methyl, tert-butyl, methoxy, -CF3, -CN, fluoro, chloro, methoxycarbonyl, or benzoyl. In some embodiments, X2 is N. In other embodiments, X1 is N. In some embodiments, Rc is H, methyl, ethyl, CF3, cyclopropyl, or cyclobutyl. In further embodiments, Rc is H or methyl. In some embodiments, n is 1. In some embodiments, Z is N or CH. In further embodiments, Z is CH. In some embodiments, R6 is H, methyl, ethyl, propyl, isopropyl, cyclopropyl, or cyclobutyl. In further embodiments, R6 is H or methyl. in some embodiments, R8 is H. In some embodiments, R9 and R10 are each independently H or methyl. In further embodiments, R9 and R10 are both H. In some embodiments, R11 is H or methyl. In further embodiments, R11 is methyl. The invention includes also pharmaceutically acceptable salts of the compounds represented by Formula (I), preferably of those described above and of the specific compounds exemplified herein. A "pharmaceutically acceptable salt" is intended to mean a salt of a free acid or base of a compound represented by Formula (I) that is non-toxic, biologically tolerable, or otherwise biologically suitable for administration to the subject. See/generally, S.M. Berge, et al., "Pharmaceutical Salts", J. Pharm. Sci., 1977, 66:1-19, and Handbook of Pharmaceutical Salts, Properties, Selection, and Use, Stahl and Wermuth, Eds., Wiley-VCH and VHCA, Zurich, 2002. Examples of pharmaceutically acceptable salts are those that are pharmacologically effective and suitable for contact with the tissues of patients without undue toxicity, irritation, or allergic response. A compound of Formula (I) may possess a sufficiently acidic group, a sufficiently basic group, or both types of functional groups, and accordingly react with a number of inorganic or organic bases, and inorganic and organic acids, to form a pharmaceutically acceptable salt. Examples of pharmaceutically acceptable salts include sulfates, pyrosulfates, bisulfates, sulfites, bisulfrtes, phosphates, monohydrogen- phosphates, dihydrogenphosphates, metaphosphates, pyrophosphates, chlorides, bromides, iodides, acetates, propionates, decanoates, caprylates, acrylates, formates, isobutyrates, caproates, heptanoates, propiolates, oxalates, malonates, succinates, suberates, sebacates, fumarates, maleates, butyne-1,4- dioates, hexyne-1,6-dioates, benzoates, chlorobenzoates, methylbenzoates, dinitrobenzoates, hydroxybenzoates, methoxybenzoates, phthalates, sulfonates, xylenesulfonates, phenylacetates, phenylpropionates, phenylbutyrates, citrates, lactates, v-hydroxybutyrates, glycolates, tartrates, methane-sulfonates, propanesuffonates, naphthalene-1-sulfonates, naphthalene-2-sulfonates, and mandelates. If the compound of Formula (I) contains a basic nitrogen, the desired pharmaceutically acceptable salt may be prepared by any suitable method available in the art, for example, treatment of the free base with an inorganic acid, such as hydrochloric acid, hydrobromic acid, sulfuric acid, sulfamic acid, nitric acid, boric acid, phosphoric acid, and the like, or with an organic acid, such as acetic acid, phenylacetic acid, propionic acid, stearic acid, lactic acid, ascorbic acid, maleic acid, hydroxymaleic acid, isethionic acid, succinic acid, valeric acid, fumarie acid, malonic acid, pyruvic acid, oxalic acid, glycolic acid, salicylic acid, oleic acid, palmitic acid, lauric acid, a pyranosidyl acid, such as glucuronic acid or galacturonic acid, an alpha-hydroxy acid, such as mandelic acid, citric acid, or tartaric acid, an amino acid, such as aspartic acid or glutamic acid, an aromatic acid, such as benzoic acid, 2-acetoxybenzoic acid, naphthoic acid, or cinnamic acid, a sulfonic acid, such as laurylsulfonic acid, p-toluenesulfonic acid, methanesulfonic acid, ethanesulfonic acid, any compatible mixture of acids such as those given as examples herein, and any other acid and mixture thereof that are regarded as equivalents or acceptable substitutes in light of the ordinary level of skill in this technology. If the compound of Formula (I) Is an acid, such as a carboxylic acid or sulfonic acid, the desired pharmaceutically acceptable salt may be prepared by any suitable method, for example, treatment of the free acid with an inorganic or organic base, such as an amine (primary, secondary or tertiary), an alkali metal hydroxide, alkaline earth metal hydroxide, any compatible mixture of bases such as those given as examples herein, and any other base and mixture thereof that are regarded as equivalents or acceptable substitutes in light of the ordinary level of skill in this technology. Illustrative examples of suitable salts include organic salts derived from amino acids, such as glycine and arginine, ammonia, carbonates, bicarbonates, primary, secondary, and tertiary amines, and cyclic amines, such as benzylamines, pyrrolidines, piperidine, morpholine, and piperazine, and inorganic salts derived from sodium, calcium, potassium, magnesium, manganese, iron, copper, zinc, aluminum, and lithium. The invention also relates to treatment methods employing pharmaceutically acceptable prodrugs of the compounds of Formula (I). The term "prodrug" means a precursor of a designated compound that, following administration to a subject, yields the compound in vivo via a chemical or physiological process such as solvolysis or enzymatic cleavage, or under physiological conditions (e.g., a prodrug on being brought to physiological pH is converted to the compound of Formula (I)). A "pharmaceutically acceptable prodrug" is a prodrug that is not toxic, biologically intolerable, or otherwise biologically unsuitable for administration to the subject. Illustrative procedures for the selection and preparation of suitable prodrug derivatives are described, for example, in "Design of Prodrugs", ed. H. Bundgaard, Elsevier, 1985. Examples of prodrugs include compounds having an amino acid residue, or a polypeptide chain of two or more (e.g., two, three or four) amino acid residues, covalently joined through an amice or ester bond to a free amino, hydroxy, or carboxylic acid group of a compound of Formula (I). Examples of amino acid residues include the twenty naturally occurring amino acids, commonly designated by three letter symbols, as well as 4-hydroxyproline, hydroxylysine, demosine, isodemosine, 3-methyihistidine, norvalin, beta-alanine, gamma-aminobutyric acid, citrulline homocysteine, homoserine, ornithine and methionine sulfone. Additional types of prodrugs may be produced, for instance, by derivatizing free carboxyl groups of structures of Formula (I) as amides or alkyl esters. Examples of amides include those derived from ammonia, primary C1-6alkyl amines and secondary di(C1-6alkyl) amines. Secondary amines include 5- or 6- membered heterocycloalkyl or heteroaryl ing moieties. Examples of amides include those that are derived from ammonia, C1-3alkyl primary amines, and di(Ci. 2alkyl)amines. Examples of esters of the invention include d1-7alkyl, C5-7. cycloalkyl, phenyl, and phenyl(C1-6alkyl) esters. Preferred esters include methyl esters. Prodrugs may also be prepared by derivatizing free hydroxy groups using groups including hemisuccinates, phosphate esters, dimethylaminoacetates, and phosphoryloxymethyloxycarbonyls, following procedures such as those outlined in Adv. Drug Delivery Rev. 1996, 19,115. Carbamate derivatives of hydroxy and amino groups may also yield prodrugs. Carbonate derivatives, sulfonate esters, and sulfate esters of hydroxy groups may also provide prodrugs. Derivatization of hydroxy groups as (acyloxy)methyl and (acyloxy)ethyl ethers, wherein the acyl group may be an alkyl ester, optionally substituted with one or more ether, amine, or carboxylic acid functionalities, or where the acyl group is an amino acid ester as described above, is also useful to yield prodrugs. Prodrugs of this type may be prepared as described in J. Med. Chem. 1996, 39,10. Free amines can also be derivatized as amides, sulfonamides or phosphonamides. All of these prodrug moieties may incorporate groups including ether, amine, and carboxylic acid functionalities. Pharmaceutically active metabolites may also be used in the methods of the invention. A "pharmaceutically active metabolite" means a pharmacologically active product of metabolism in the body of a compound of Formula (I) or salt thereof. Prodrugs and active metabolites of a compound may be determined using routine techniques known or available in the art. See, e.g., Bertolini, et al., J. Med. Chem. 1997, 40, 2011-2016; Shan, et al., J. Pharm. Scl. 1997, 86 (7), 765-767; Bagshawe, Drug Dev. Res. 1995, 34, 220-230; Bodor, Adv. Drug Res. 1984, 13, 224-331; Bundgaard, Design of F'rodrugs (Elsevier Press, 1985); and Larsen, Design and Application of Prodrugs, Drug Design and Development (Krogsgaard-Larsen, et al., eds., Harwood Academic Publishers, 1991). The compounds of Formula (I) and their pharmaceutically acceptable salts, pharmaceutically acceptable prodrugs, and pharmaceutically active metabolites (collectively, "agents") of the present invention are useful as histamine H4 receptor modulators in the methods of the invention. The agents may be used in the inventive methods for the treatment or prevention of medical conditions, diseases, or disorders mediated through modulation of the histamine H4 receptor, such as those described herein. Agents according to the invention may therefore be used as an anti-inflammatory agents. Symptoms or disease states are intended to be included within the scope of "medical conditions, disorders, or diseases." Accordingly, the invention relates to methods of using the pharmaceutical agents described herein to treat subjects diagnosed with or suffering from a disease, disorder, or condition mediated through histamine H4 receptor activity, such as inflammation. In a preferred embodiment, an agent: of the present invention is administered to treat inflammation. Inflammation may be associated with various diseases, disorders, or conditions, such as inflammatory disorders, allergic disorders, dermatologica! disorders, autoimmune disease, lymphatic disorders, and immunodeficiency disorders, including the more specific conditions and diseases given below. Regarding the onset and evolution of inflammation, inflammatory diseases or inflammation-mediated diseases or conditions include, but are not limited to, acute inflammation, allergic inflammation, and chronic inflammation. Illustrative types of inflammation treatable with a histamine H4 receptor- modulating agent according to the invention include inflammation due to or associated with any one of a plurality of conditions such as allergy, asthma, dry eye, chronic obstructed pulmonary disease (COPD), atherosclerosis, rheumatoid arthritis, multiple sclerosis, inflammatory bowel diseases (including colitis, Crohn's disease, and ulcerative colitis), psoriasis, pruritis, itchy skin, atopic dermatitis, urticaria (hives), ocular inflammation, conjunctivitis, nasal polyps, allergic rhinitis, nasal itch, scleroderma, autoimmune thyroid diseases, immune-mediated (also known as type 1) diabetes mellitus and lupus, which are characterized by excessive or prolonged inflammation at seme stage of the disease. Other autoimmune diseases that lead to inflammation include Myasthenia gravis, autoimmune neuropathies, such as Guillam-Barre, autoimmune uveitis, autoimmune hemolytic anemia, pernicious anemia, autoimmune thrombocytopenia, temporal arteritis, anti-phospholipid syndrome, vasculites, such as Wegener's granulomatosis, Behcet's disease, dermatitis herpetiformis, pemphigus vulgaris, vitiligio, primary biliary cirrhosis, autoimmune hepatitis, autoimmune oophoritis and orchitis, autoimmune disease of the adrenal gland, polymyositis, dermatomyositis, spondyloarthropathies, such as ankylosing spondylitis, and Sjogren's syndrome. Pruritis with a histamine H4 receptor-modulating agent according to the invention includes that which is a symptom of allergic cutaneous diseases (such as atopic dermatitis and hives) and other metabolic disorders (such as chronic renal failure, hepatic cholestasis, and diabetes mellitus). In another preferred embodiment, an agent of the present invention is administered to treat allergy, asthma, autoimmune diseases, or pruritis. The term "treat" or "treating" as used herein is intended to refer to administration of an agent or composition of the invention to a subject for the purpose of effecting a therapeutic or prophylactic benefit through modulation of histamine H4 receptor activity. Treating includes reversing, ameliorating, alleviating, inhibiting the progress of, lessening the severity of, or preventing a disease, disorder, or condition, or one or more symptoms of such disease, disorder or condition mediated through modulation of histamine H4 receptor activity. The term "subject" refers to a mammalian patient in need of such treatment, such as a human. "Modulators" include both inhibitors and activators, where "inhibitors" refer to compounds that decrease, prevent, inactivate, desensitize or down-regulate histamine H4 receptor expression or activity, and "activators" are compounds that increase, activate, facilitate, sensitize, or up- regulate histamine H4 receptor expression or activity. In treatment methods according to the invention, an effective amount of at least one pharmaceutical agent according to the invention is administered to a subject suffering from or diagnosed as having such a disease, disorder, or condition. An "effective amount" means an amount or dose sufficient to generally bring about the desired therapeutic or prophylactic benefit in patients in need of such treatment for the designated disease, disorder, or condition. Effective amounts or doses of the agents of the present invention may be ascertained by routine methods such as modeling, dose escalation studies or clinical trials, and by taking into consideration routine factors, e.g., the mode or route of administration or drug delivery, the pharmacokinetics of the agent, the severity and course of the disease, disorder, or condition, the subject's previous or ongoing therapy, the subject's health status and response to drugs, and the judgment of the treating physician. An example of a dose is in the range of from about 0.001 to about 200 mg of agent per kg of subject's body weight per day, preferably about 0.05 to 100 mg/kg/day, or about 1 to 35 mg/kg/day, in single or divided dosage units (e.g., BID, TID, QID). For a 70-kg human, an illustrative range for a suitable dosage amount is from about 0.05 to about 7 g/day, or about 0.2 to about 2.5 g/day. Once improvement of the patient's disease, disorder, or condition has occurred, the dose may be adjusted for preventative or maintenance treatment. For example, the dosage or the frequency of administration, or both, may be reduced as a function of the symptoms, to a level at which the desired therapeutic or prophylactic effect is maintained. Of course, if symptoms have been alleviated to an appropriate level, treatment may cease. Patients may, however, require intermittent treatment on a long-term basis upon any recurrence of symptoms, In addition, the agents of the invention may be used in combination with additional active compounds in the treatment of the above conditions. The additional compounds may be coadministered separately with an agent of Formula (I) or Included with such an agent as an additional active ingredient in a pharmaceutical composition according to the invention. In an illustrative embodiment, additional active compounds are those that are known or discovered to be effective in the treatment of conditions, disorders, or diseases mediated by histamine H4 receptor activity, such as another histamine H4 receptor modulator or a compound active against another target associated with the particular condition, disorder, or disease. The combination may serve to increase efficacy (e.g., by including in the combination a compound potentiating the potency or effectiveness of an agent according to the invention), decrease one or more side effects, or decrease the required dose of 'the agent according to the invention. When referring to modulating the target receptor, an "effective amount" means an amount sufficient to affect the activity of such receptor. Measuring the activity of the target receptor may be performed by routine analytical methods. Target receptor modulation is useful in a variety of settings, including assays. The agents of the invention are used, alone or in combination with one or more other active ingredients, to formulate pharmaceutical compositions of the invention. A pharmaceutical composition of the invention comprises an effective amount of at least one pharmaceutical agent in accordance with the invention. A pharmaceutically acceptable excipient is part of some embodiments of pharmaceutical compositions according to this invention. A "pharmaceutically acceptable excipient" refers to a substance that is not toxic, biologically intolerable, or otherwise biologically unsuitable for administration to a subject, such as an inert substance, added to a pharmacological composition or otherwise used as a vehicle, carrier, or diluent to facilitate administration of a pharmaceutical agent and that is compatible therewith. Examples of excipients include calcium carbonate, calcium phosphate, various sugars and types of starch, cellulose derivatives, gelatin, vegetable oils, and polyethylene glycols. Delivery forms of the pharmaceutical compositions containing one or more dosage units of the pharmaceutical agents may be prepared using suitable pharmaceutical excipients and compounding techniques known or that become available to those skilled in the art. The compositions may be administered in the inventive methods by a suitable route of delivery, e.g., oral, parenteral, rectal, topical, or ocular routes, or by inhalation. The preparation may be in the form of tablets, capsules, sachets, dragees, powders, granules, lozenges, powders for reconstitution, liquid preparations, or suppositories. Preferably, the compositions are formulated for intravenous infusion, topical administration, or oral administration. For oral administration, the compounds of the invention can be provided in the form of tablets or capsules, or as a solution, emulsion, or suspension. To prepare the oral compositions, the agents may be formulated to yield a dosage of, e.g., from about 0.05 to about 50 mg/kg daily, or from about 0.05 to about 20 mg/kg daily, or from about 0.1 to about 10 mg/kg daily. Oral tablets may include the agent and any other active ingredients mixed with compatible pharmaceutlcally acceptable excipients such as diluents, disintegrating agents, binding agents, lubricating agents, sweetening agents, flavoring agents, coloring agents and preservative agents. Suitable inert fillers include sodium and calcium carbonate, sodium and calcium phosphate, lactose, starch, sugar, glucose, methyl cellulose, magnesium stearate, mannitol, sorbitol, and the like. Examples of liquid oral excipients include ethanol, glycerol, water, and the like. Starch, polyvinyl-pyrrolidone (PVP), sodium starch glycolate, microcrystalline cellulose, and aiginic acid are examples of disintegrating agents. Binding agents may include starch and gelatin. The lubricating agent, if present, may be magnesium stearate, stearic acid or talc. If desired, the tablets may be coated with a material such as glyceryl monostearate or glyceryl distearate to delay absorption in the gastrointestinal tract, or may be coated with an enteric coating. Capsules for oral administration include hard and soft gelatin capsules. To prepare hard gelatin capsules, active ingredient may be mixed with a solid, semi- solid, or liquid diluent. Soft gelatin capsules: may be prepared by mixing the active ingredient with water, an oil such as peanut oil or olive oil, liquid paraffin, a mixture of mono and di-glycerides of short chain fatty acids, polyethylene glycol 400, or propylene glycol. Liquids for oral administration may be in the form of suspensions, solutions, emulsions or syrups or may be lyophilized or presented as a dry product for reconstitution with water or other suitable vehicle before use. Such liquid compositions may optionally contain: pharmaceutically-acceptable excipients such as suspending agents (for example, sorbitol, methyl cellulose, sodium alginate, gelatin, hydroxyethylcellulose, carboxymethylcellulose, aluminum stearate gel and the like); non-aqueous vehicles, e.g., oil (for example, almond oil or fractionated coconut oil), propylene glycol, ethyl alcohol, or water; preservatives (for example, methyl or propyl p-hydroxybenzoate or sorbic acid); wetting agents such as lecithin; and, if desired, flavoring or coloring agents. The active agents of this invention may also be administered by non-oral routes. For example, the compositions may be formulated for rectal administration as a suppository. For parenteral use, including intravenous, intramuscular, intraperitoneal, or subcutaneous routes, the agents of the invention may be provided in sterile aqueous solutions or suspensions, buffered to an appropriate pH and isotonicity or in parentarally acceptable oil. Suitable aqueous vehicles include Ringer's solution and isotonic sodium chloride. Such forms may be presented in unit-dose form such as ampules or disposable injection devices, in multi-dose forms such as vials from which the appropriate dose may be withdrawn, or in a solid form or pre-concentrate that can be used to prepare an injectable formulation. Illustrative infusion closes range from about 1 to 1000 ng/kg/minute of agent, admixed with a pharmaceutical carrier over a period ranging from several minutes to several days. For topical administration, the agents may be mixed with a pharmaceutical carrier at a concentration of about 0.1 % to about 10% of drug to vehicle. Another mode of administering the agents of the invention may utilize a patch formulation to affect transdermal delivery. Agents may alternatively be administered in methods of this invention by inhalation, via the nasal or oral routes, e.g., in a spray formulation also containing a suitable carrier. Examples of agents useful in methods of the invention will now be described by reference to illustrative synthetic schemes for their general preparation below and the specific examples that follow. Artisans will recognize that, to obtain the various compounds herein, starting materials may be suitably selected so that the ultimately desired substituents will be carried through the reaction scheme with or without protection as appropriate to yield the desired product. Alternatively, it may be necessary or desirable to employ, in the place of the ultimately desired substituent, a suitable group that may be carried through the reaction scheme and replaced as appropriate with the desired substituent. Unless otherwise specified, the variables are as defined above in reference to Formula (I). In the Schemes depicted below, one skilled in the art will recognize that R11 may be replaced with a suitable nitrogen protecting group, such as a tert- butoxycarbonylgroup (Boc), and that protecting group replaced at a later stage in the synthesis. Referring to Scheme A, amines A2 are commercially available or are prepared from acids A1 or alcohols A3. Coupling of acids A1 with amines R6NH2, in the presence of activating agents such as dicyclohexyl-carbodiimide, EDC/HOBt, or carbonyl diimidazole, in a solvent such as DMF or THF, provides the corresponding amides (not shown). Alternatively, acids A1 are activated to their corresponding acid chlorides and reacted with amines R6NH2 in the presence of a suitable base such as triethylamine or diisopropylethylamine, in a solvent such as DCM or THF. The resulting amides are reduced to amines A2 by a suitable reducing agent such as LiAIH4, in a solvent such as THF. Alcohols A3 are activated using general methods to form, for example, alkyi halides or alkyl tosylates. Displacement with R6NH2 in the presence of a suitable base such as NaH, NaOH, triethylamine, or diisopropylethylamine, in a solvent such as DCM or THF, provides amines A2. Alternatively, amines A2 are prepared from alcohols A3 by reaction with phthalimide or a suitable amino surrogate under Mitsunobu conditions. Where phthalimide is used, the free amine is revealed through treatment with hydrazine. Referring to Scheme B, amines A2 are reacted with pyrimidines B1, which are commercially available or are prepared by oxidation of commercially available alkylsulfanyl pyrimidines, or by other general methods, in a solvent such as pyridine, DMF, MeOH, or EtOH, or a mixture thereof, at temperatures between about room temperature and the reflux temperature of the solvent, or in a sealed tube at temperatures up to about 120 °C. 2-Aminopyrimidines B2 are converted to aldehydes B3 by reduction of the Y substituent with a suitable reducing agent such as diisobutylaluminum hydride. Where Y is an ester group, reduction produces aldehydes B3 or the corresponding alcohols (not shown). Where an alcohol is produced, oxidation using a suitable oxidizing agent such as MnO2, Dess-Martin periodinane, or Swern conditions, provides aldehydes B3. Condensation of aldehydes B3 with suitably substituted diamines B4, in the presence of a dehydrating agent such as NaH2S2O5, in a solvent such as DMF, MeOH, or EtOH, or a mixture thereof, at temperatures between about room temperature and the reflux temperature of the solvent, produces compounds of Formula (I). Referring to Scheme C, acids A1 or alcohols A3 may be coupled with 2- aminopyrimidines C1 using the methods described in Scheme A to form amides and amines C2. Compounds C2 are processed as described in Scheme B to provide compounds of Formula (I). Referring to Scheme D, amines A2 are reacted with pyrazines D1, which are commercially available or are prepared by general methods, in a solvent such as pyridine, MeOH, or EtOH, or a mixture thereof, at temperatures between about room temperature and the reflux temperature of the solvent, or in a sealed tube at temperatures up to about 120 °C. 2-Aminopyrazines D2 are processed into compounds of Formula (I) as shown in Scheme D using methods analogous to those described in Scheme B. Additional synthetic methods are described in U.S. Pat. Appl. Publ. 2005/0070550A1, which is hereby incorporated by reference. Compounds prepared according to the schemes described above may be obtained as single enantiomers, diastereomers, or regioisomers, or as racemic mixtures or mixtures of enantiomers, diastereomers, or regioisomers. Where regioisomeric or diastereomeric mixtures are obtained, isomers may be separated using conventional methods such as chromatography or crystallization. Where racemic (1:1) and non-racemic (not 1:1) mixtures of enantiomers are obtained, single enantiomers may be isolated using conventional separation methods known to one skilled in the art. Particularly useful separation methods may include chiral chromatography, recrystallization, diastereomeric salt formation, or derivatization into diastereomeric adducts followed by separation. The following examples are provided to further illustrate aspects of the invention and various preferred embodiments. EXAMPLES Chemistry: In obtaining the compounds described in the examples below and the corresponding analytical data, the following experimental and analytical protocols were followed unless otherwise indicated. Unless otherwise stated, reaction mixtures were magnetically stirred at room temperature (rt). Where solutions are "dried," they are generally dried over a drying agent such as Na2SO4 or MgSO4. Where mixtures, solutions, and extracts were "concentrated", they were typically concentrated on a rotary evaporator under reduced pressure. Thin-layer chromatography was performed using Merck silica gel 60 F264 2.5 cm x 7.5 cm 250 μm or 5.0 cm x 10.0 cm 250 μm pre-coated silica gel plates. Preparative thin-layer chromatography was performed using EM Science silica gel 60 F254 20 cm x 20 cm 0.5 mm pre-coated plates with a 20 cm x 4 cm concentrating zone. Normal-phase flash column chromatography (FCC) was performed on silica gel (SiO2) eluting with 2 M NH3 in MeOH/DCM, unless otherwise noted. Reaction mixtures were loaded onto the Si02 column without workup. Reversed-phase HPLC was performed on a Hewlett Packard HPLC Series 1100, with a Phenomenex Luna C18 (5 μm, 4.6x150 mm) column. Detection was done at A, = 230,254 and 280 nm. The gradient was 10 to 99% acetonitrile/water (0.05% trifluoroacetic acid) over 5.0 min with a flow rate of 1 mL/min. Alternatively, HPLC was performed on a Dionex APS2000 LC/MS with a Phenomenex Gemini C18 (5 μm, 30 x 100 mm) column, and a gradient of 5 to 100% acetonitrile/water (20 mM NH4OH) over 16.3 min, and a flow rate of 30 mL/min. Mass spectra (MS) were obtained on an Agilent series 1100 MSO using electrospray ionization (ESI) in positive mode unless otherwise indicated. Calculated (calcd.) mass corresponds to the exact mass. Nuclear magnetic resonance (NMR) spectra were obtained on Bruker model DRX spectrometers. The format of the 1H NMR data below is: chemical shift in ppm downfield of the tetramethylsilane reference (multiplicity, coupling constant J in Hz, integration). Chemical names were generated using ChemDraw Version 6.0.2 (CambridgeSoft, Cambridge, MA). Example 1. [5-(5-Fluoro-4-methyl-1H-benzoimidazol-2-yl)4-methyl-pyrimidin-2- yl]-[3-(1 -methyl-piperidin-4-yl)-propyl]-amine. Step A: 4-methyl-2-ethylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester. A mixture of ethyl acetoacetate (6.37 mL, 50.0 mol), dimethylformamide dimethylacetal (8.94 g, 75.0 mmol), and catalytic p-toluenesulfonic acid was heated at 100 °C for 2 h. After cooling to it, the mixture was diluted with N.N- dlmethylformamide (DMF; 50 mL) and 2-ethylisothiourea hydrobromide (9.10 g, 50.0 mmol) was added. After heating the at 100 °C for 18 h, the mixture was cooled to rt and concentrated to give a crude residue, which was purified by FCC (EtOAc/hexanes) to give 7.1 g (61%) of a solid. 1H NMR (CDCI3): 8.97-8.91 (m, 1H), 4.43-4.35 (m, 2H), 3.24-3.15 (m, 2H), 2.81-2.72 (m, 3H), 1.47-1.35 (m, 6H). Step B; 2-Ethanesulfonyl-4-methyl-pyrimidine-5-carboxylic acid ethyl ester. To a 0 °C solution of 4-methyl-2-ethylsuHanyl-pyrimidine-5-carboxylic acid ethyl ester (3 g, 13.3 mmol) in dichloromethane (DCM; 50 mL) was added urea hydrogen peroxide (5.20 g, 55.7 mmol) followed by trifluoroacetic anhydride (7.39 mL, 53.1 mmol) dropwise. The solution was warmed to rt for 2 h before quenching with satd. aq. Na2S2O3 (20 mL) and extracting with DCM (100 mL). The organic layer was dried (Na2SO4) and concentrated to give 1.50 g of an orange solid which was used immediately in the next step without purification. 1H NMR (CDCI3): 9.28 (s, 1H), 4.47 (q, J = 7.2 Hz, 2H), 3.60 (q, J = 7.5 Hz, 2H), 2.96 (s, 3H), 1.47-1.42 (m,6H). Step C:4-methyl-2-[3-(1-methyl-piperidin-4-yl)-propylamino]-pyrimidine-5- carboxylic acid ethyl ester. A mixture of 2-ethanesulfonyl-4-methyl-pyrimidine-5- carboxylic acid ethyl ester (0.30 g, 1.18 mmol) and 3-(1-methyl-piperidin-4-yl)- propylamine (0.18 mg, 1.10 mmol) in EtOH (3 mL) was heated in a sealed tube at 100 °C for 6 h. The mixture was concentrated and purified by FCC to give 200 mg (53%). 1H NMR (CDCI3): 8.88-8.72 (m, 1H), 5.60-5.44 (m, 1H), 4.31 (q, J = 7.2 Hz, 2H), 3.52-3.39 (m, 2H), 2.91-2.77 (m, 2H), 2.64 (s, 3H), 2.26 (s, 3H), 1.94- 1.85 (m, 2H), 1.72-1.57 (m, 4H). 1.41-1.20 (m, 8H). Step D: {4-methyl-2-[3-(1 -methyl-piperidin-4-yl)propylamino]-pyrimidin-5- yl}-methanol. To a 0 °C solution of 4-methyl-2-[3-(1-methyl-piperidin-4-yl)- propylamino]-pyrimidine-5-carboxylic acid ethyl ester (0.20 g, 0.63 mmol) in THF (6 mL) was added diisobutylaluminum hydride (1 M in hexanes; 1.25 mL, 1.25 mmol) dropwise. The mixture was wanned to rt over 1 h. The reaction was quenched with 1 M H2SO4 (2 mL). The mixture was neutralized with satd. aq. NaHCO3, and diluted with MeOH (2 mL), CHCI3 (10 mL), and satd. aq. sodium potassium tartrate (10 mL). The mixture was stirred vigourously until the layers separated. The organic layer was dried (Na2SO4) and concentrated to give the crude product (138 mg), which was used in the next step without further purification. 1H NMR (CDCI3): 8.07 (s, 1H), 4.52 (s, 2H), 3.42-3.33 (m, 2H), 2.88- 2.74 (m, 2H), 2.41 (s, 3H), 2.23 (s, 3H). 1.93-1.83 (m, 2H), 1.72-1.53 (m, 4H), 1.35-1.16 (m,5H). Step E: [5-(5-Fluoro-4-methyl- 1H-benzoimidazol-2-yl)-pyrimidin.2-yl]-[3-(1- methyl-piperidin-4-ylpropyl-amine. A mixture of 4-methyl-2-[3-(1-methyl- piperidin-4-yl)-propylamino]-pyrimidin-5-yl)-methanol (0.14 g. 0.49 mmol) in toluene (3 mL) was added MnO2 (0.22 g. 2.48 mmol). After 30 min at 70 °C, the mixture was filtered through diatomaceous earth. The filtrate was concentrated and immediately dissolved in DMF. A portion of this solution (corresponding to 0.05 mg, 0.17 mmol of 4-methyl-2-[3-(1-methyl-piperidin-4-yl)-propylamino]- pyrimidine-5-carbaldehyde) was then treated with 4-fluoro-3-methyl-benzene-1,2- diamine (1.1 equiv.) and Na2H2S2O5 (1.25 equiv.) at 90 °C for 12 h. The reaction mixture was purified by FCC to afford the title compound. MS: mass calcd. for C22H29FN6, 396.24; m/z found, 397.2 [M+H]+. 1H NMR (CD3OD): 8.62 (s, 1H), 7.55 (dd, J = 8.0, 3.9 Hz, 1H), 7.17 (dd, J = 10.3, 8.8 Hz, 1H), 3.60 (t, J = 6.9 Hz, 2H), 3.10-2.99 (m, 2H). 2.71 (s, 3H). 2.66 (d, J = 1.4 Hz, 3H), 2.44 (s, 3H), 2.26- 2.17 (m, 2H), 1.98-1.88 (m, 2H), 1.87-1.77 (m, 2H). 1.55-1.36 (m, 5H). The following compounds in Examples 2-14 were synthesized analogously to the procedures described in Example 1. Example 2, [5-(4,6-Dimethyl-1h-benzoimldazol-2yl)-4-methyl-pyrimidin-2-yl]-[3- (1-methyl-piperidin-4-yl)-propyl]-amine MS: mass calcd. for C23H32N6, 392.27; m/z found, 393.3 [M+H]. 1H NMR (CD3OD): 8.43 (s, 1H), 7.20 (s, 1H), 6.89 (s, 1H), 3.41 (t, J = 7.0 Hz, 2H), 2.89- 2.82 (m, 2H), 2.54 (s, 3H), 2.53 (s, 3H), 2.42 (3, 3H), 2.25 (s, 3H), 2.05-1.96 (m. 2H), 1.78-1.70 (m, 2H), 1.69-1.59 (m, 2H), 1.34-1.21 (m, 5H). Example 3, [5-(6-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3- (1-methyl-piperidin-4-yl)-propyl]-amine MS: mass calcd. for C22H29FN6, 396.24; m/z found, 397.3 [M+H]+. 1H NMR (CD3OD): 8.45 (s, 1H), 7.10 (dd, J = 8.9, 2.1 Hz, 1H). 6.85 (dd, J = 10.5, 1.5 Hz, 1H), 3.42 (t, J = 7.0 Hz, 2H), 2.90-2.82 (m, 2H), 2.58 (s, 3H), 2.54 (s, 3H), 2.25 (s, 3H), 2.05-1.93 (m, 2H). 1.78-1.71 (m, 2H), 1.69-1.60 (m, 2H), 1.39-1.18 (m, 5H). Example 4. [5-(4.5-Difluoro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl)-amine. MS: mass calcd. for C21H26F2N6, 400.22; m/z found. 401.2 [M+H]+. 1H NMR (CD3OD): 8.49 (s, 1H), 7.32 (ddd, J = 8.8, 3.7,1.1 Hz, 1H), 7.17 (ddd, J = 11.4. 8.8, 7.2 Hz, 1H), 3.43 (t, J = 7.0 H2:, 2H), 2.93-2.82 (m, 2H), 2.58 (s, 3H), 2.27 (s, 3H), 2.08-1.97 (m, 2H), 1.79-1.71 (m, 2H), 1.70-1.60 (m, 2H), 1.40-1.16 (m, 5H). Example 5. [5-(4.5-Dimethyl-1 H-benzoirnidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3- (1-methyl-piperidin-4-yl)-propyl]-amine. MS: mass calcd. for C23H32N6, 392.27; m/z found, 393.3 [M+H]+. 1H NMR (CD3OD): 8.44 (s, 1H), 7.31 (d, J = 7.7 Hz, 1H), 7.07 (d, J = 8.2 Hz, 1H), 3.43 (t, J = 7.3 Hz, 1H), 2.92-2.82 (m, 2H), 2.53 (s, 3H), 2.51 (s, 3H), 2.39 (s, 3H). 2.26 (s, 3H), 2.07-1.96 (m, 2H), 1.79-1.71 (m, 2H), 1.71-1.61 (m, 2H), 1.41-1.16 (m, 5H). Example 6. [5-(4.6-Difluoro-1 H-benzoimidazol-2-yl)-4-methyl-Pyrimidin-2-yl]-[3-(1 - methyl-piperidin-4-yl)-propyl]-amine. MS: mass calcd. for C21H26F2N6, 400.22; m/z found, 401.2 [M+H]+. 1H NMR (CD3OD): 8.48 (s, 1H), 7.13 (dd. J = 8.5, 2.1 Hz, 1H), 6.88 (dt, J = 10.4, 10.4, 2.2 Hz, 1H), 3.42 (t, J = 6.9 Hz, 2H), 2.91-2.82 (m, 2H), 2.57 (s, 3H), 2.26 (s, 3H), 2.07-1.97 (m, 2H), 1.80-1.71 (m, 2H), 1.70-1.59 (m, 2H), 1.40-1.17 (m, 5H). Example 7. [5-(4.6-Dimethyl-1 H-benzoimidazol-2-yl]-4-methyl-pyrimidin-2-yl]- methyl-[3-(1-methyl-piperidin-4-yl)-propyl]-amine. MS: mass calcd. for C24H34N6,406 28; m/z found, 407.3 [M+H]+. 1H NMR (CD3OD): 8.31 (s, 1H), 7.04 (s, 1H), 6.73 (s, 1H), 3.55 (t, J = 7.3 Hz, 2H), 3.04 (s, 3H), 2.75-2.67 (m, 2H). 2.39 (s, 6H). 2.26 (s, 3H). 2.10 (s, 3H), 1.90-1.82 (m, 2H), 1.63-1.47 (m, 4H), 1.17-1.01 (m, 5H). Example 8. [5-(4.5-Dimethyl-1 H-benzoimidazol-2-yl)-4-ethyl-Pyrimidin-2-yl]- methyl-[3-(1-methyl-piperidin-4-yl)-propyl]-amine. MS: mass calcd. for C24H34N6,406.28; m/z found, 407.3 [M+H]+. 1H NMR (CD3OD): 8.37 (s, 1H), 7.31 (d, J = 8.1 Hz, 1H), 7.06 (d, J = 8.2 Hz, 1H), 3.43 (t, J = 6.2 Hz, 2H), 2.94-2.81 (m, 4H), 2.50 (s, 3H), 2.39 (s, 3H), 2.25 (s, 3H). 2.05- 1.95 (m,2H), 1.79-1.70 (m,2H), 1.71-1.61 (m, 2H). 1.40-1.10 (m, 8H). Example 9. [5-(4.5-Difluoro-1 H-benzoimiclazol-2-yl]-4-ethyl-pyrimidin-2-yl]-[3-1- methyl-piperidin-4-yl)-propyl]-amine. MS: mass calcd. for C22H28F2N6, 414.23; m/z found, 415.3 [M+H]+. 1H NMR (CD3OD): 8.42 (s, 1H), 7.32 (ddd, J = 8.8, 3.6, 1.2 Hz, 1H), 7.17 (ddd, J = 11.4, 8.8, 7.2 Hz, 1H), 3.48-3.39 (m, 2H), 3.01-2.91 (m. 2H), 2.90-2.83 (m. 2H), 2.26 (s, 3H), 2.07-1.96 (m, 2H), 1.79-1.60 (m, 4H), 1.38-1.11 (m, 8H). Example 10. [5-(4-Fluoro-5-methyl-1H-benzoimidazoimidazol-2-yl)-4-propyl-pyrimidin-2- yl]-[3-(1-methyl-piperidin-4-yl)-propyl]-amine. MS: mass calcd. for C24H33FN6, 424.28; m/z found. 425.3 [M+H]+. 1H NMR (CD30D): 8.39 (s, 1H), 7.37 (dd, J = 8.5, 4.2 Hz. 1H), 7.00 (dd. J = 10.3, 8.9 Hz, 1H), 3.43 (t, J = 6.4 Hz, 2H), 2.91-2.82 (m 4H), 2.49 (d, J - 1.4 Hz, 3H), 2.25 (s. 3H), 2.05-1.96 (m, 2H), 1.81-1.57 Example 11. [5-(4.5-Dimethyl-1 H-benzoimidazol-2-yl)-4-isoorooyl-pyrimidin-2-yl]- [3-(1-methyl-piperidin-4-yl)-propyl]-amine- MS: mass calcd. for C25H36N6. 420.30; m/z found, 421.3 [M+H]+. 1H NMR (CD3OD): 8.30 (s, 1H), 7.31 (d, J = 8.1 Hz, 1H), 7.07 (d, J = 8.2 Hz, 1H), 3.47- 3.38 (m, 3H), 2.94-2.73 (m, 2H), 2.50 (s, 3H), 2.39 (s, 3H), 2.25 (s, 3H), 2.05-1.91 (m, 2H), 1.80-1.60 (m, 4H), 1.40-1.21 (m, 5H). 1.19 (d, J = 6.7 Hz, 6H). Example 12. [5-(4.6-Dimethyl-1 H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]- [3-(1-methyl-piperidin-4-yl)propyl]-amine. MS: mass calcd. for C25H36N6, 420.30; m/z found. 421.3 [M+H]+. 1H NMR (CD3OD): 8.29 (s, 1H), 7.19 (s. 1H), 6.90 (s, 1H), 3.50-3.37 (m, 3H), 3.07-2.97 (m, 2H). 2.54 (s, 3H), 2.43 (s, 3H), 2.40 (s, 3H), 2.30-2.20 (m, 2H), 1.85-1.78 (m, 2H), 1.73-1.64 (m, 2H), 1.42-1.26 (m, 5H), 1.19 (d, J - 6.7 Hz, 6H). Example 13. [4-Cyclobutyl-5-[4.5-dimethyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]- [3-(1-methyl-piperidin-4-yl)-propyl]-amine. MS: mass calcd. for C26H36N6, 432.30; m/z found, 433.3 [M+H]+. 1H NMR (CD3OD): 8.31 (s, 1H), 7.31 (d, J = 7.7 H2:, 1H), 7.06 (d, J = 8.2 Hz, 1H), 4.02 (p, J = 8.4 Hz, 1H), 3.57-3.38 (m, 2H), 2.93-2.81 (m. 2H), 2.50 (s, 3H), 2.39 (s. 3H), 2.38-2.32 (m, 2H), 2.26 (s, 3H), 2.14-1.86 (m, 5H), 1.87-1.61 (m, 5H), 1.43-1.18 (m, 5H). Example 14. [4-Cyclobutyl-5-(4.5-dlfluoro-1 H-benzoimidazol-2-yl)-pyrimidin-2-yl]- [3-(1-methyl-piperidln-4-yl)-propyl]-amine. MS: mass calcd. for C24H30F2N6,440.25; m/z found, 441.3 [M+Hf. 1H NMR (CD3OD): 8.36 (s, 1H), 7.32 (ddd, J = 8.8, 3.6. 1.1 Hz, 1H), 7.17 (ddd, J = 11.4, 8.8, 7.2 Hz, 1H), 4.10 ( p, J = 8.4 Hz, 1H), 3.57-3.39 (m, 2H), 2.92-2.81 (m, 2H), 2.42-2.29 (m, 2H), 2.27-2.24 (m, 3H), 2.19-2.06 (m, 2H), 2.06-1.94 (m, 2H), 1.90-1.60 (m, 6H), 1.40-1.14 (m, 5H). Example 15. [5-(5-Fluoro-4-methyl-1 H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1 - methyl-piperidin-4-yl)-propyl]-amine. The title compound was prepared from 2-methylsulfanyl-pyrimidine-5- carboxyllc acid methyl ester (Zhichkin, P. el: al., Synthesis 2002, 6, 720-722) using methods analogous to those described in Example 1. MS: mass calcd. for C21H27FN6, 382.23; m/z found, 383.4 [M+H]\ 1H NMR (CD3OD): 9.02-8.85 (m, 2H), 7.45-7.27 (m, 1H), 6.98 (dd, J = 10.1, 8.9 Hz, 1H), 3.43 (t, J - 7.1 Hz, 2H), 2.96-2.88 (m, 2H), 2.51 (s, 3H), 2.30 (s. 3H), 2.14-2.03 (m, 2H), 1.83-1.72 (m, 2H), 1.72-1.61 (m, 2H), 1.41-1.18 (m, 5H). The compounds in Examples 16-32 were prepared using methods analogous to those described in Example 1. Example 16. [4-Cyclobutyl-5-(5-fluoro-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin- 2-yl]-[3-(1-methyl-piperidin-4-yl)-propyl]-amine. MS: mass calcd. for C25H33FN6, 436.28; m/z found, 437.3 [M+H]+. Example 17. [4-Cyclobutyl-5-(4.6-dimethyl-1 H-benzoimidazol-2-yl)-pyrimidln-2-yl- [3-(1-methyl-piperidin-4-yl)-propyl]-amine. MS: mass calcd. for C26H36N6, 432.30; m/z found, 433.3 [M+H]+. Example 18. [5-(4.5-Dimethyl-1 H-benzoimidazol-2-yl)-4-propyl-pyrimidin-2-yl]-[3- (1-methyl-piperidin-4-yl)-propyl]-amine. MS: mass calcd. for C25H38N6, 420.30; m/z found, 421.3 [M+H]+. Example 19. [4-Ethyl-5-(5-fluoro-4-methyl -1 H-benzoimidazol-2-yl)-pyrimidin-2-yl]- [3-(1-methyl-piperidin-4-yl)-propyl]-amine. MS: mass calcd. for C23H31FN6,410.26; m/z found, 411.3 [M+H]+. Example 20. [5-(5-Fluoro-4-methyl-1 H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin- 2-yl]-[3-(1-methyl-piperidin-4-yl-propyl]-amine. MS: mass calcd. for C24H33FN6,424.28; m/z found. 425.3 [M+Hf. Example 21. [4-Methyl-5-(4-methyl-1H-benzoimldazol-2-yl)-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine. MS: mass calcd. for C22H30N6. 378.25; m/z found, 379.3 [M+H]+. Example 22. [5-(1 H-Benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine. MS: mass calcd. for C21H28N6, 364.24; m/z found, 365.2 [M+H]+. Example 23. [5-[5-Fluoro-1 H-benzoimidazol-2-yl)-methyl-pyrimidin-2-yl]-[3-(1 - methyl-piperldin-4-yl)-propyl]-amine. MS: mass calcd. for C21H27FN6, 382.23; m/z found, 383.2 [M+H]+. Example 24. [3-(1-methyl-piperidin-4-yl)propyl]-[4-methyl-5-(5-trifluoromethyl-1H- benzoimidazol-2-yl)-pyrimidin-2-yl]-amine. MS: mass calcd. for C22H27N6, 432.22; m/z found, 433.2 [M+H]+. Example 25. [5-(5-tert-Butyl-1 H-benzolmidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3- (1-methyl-piperidin-4-yl)-propyl]-amine. MS: mass calcd. for C25H36N6.420.30; m/z found, 421.3 [M+H]+. Example 26. [5-(5-Chloro-4-methyl-1 H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2- yl]-[3-(1-methyl-piperidin-4-yl)-propyl]-amine. MS: mass calcd. for C22H29CIN6, 412.21; m/z found, 413.2 [M+H]+. Example 27. [5-( 5-Fluoro-4-methyl-1 H-benzoimidazol-2-yl)-4-trifluoromethyl- pyrimidin-2-yl]-[3-(1-methyl-piperidin-4-yl)-propyl]-amine. MS: mass calcd. for C22H26F4N6,450.22; m/z found, 451.2 [M+H]. Example 28. [5-(6-Ftuoro-4-methyl-1 H-berizoimidazol-2-yl)-4-trifluoromethyl- pyrimidin-2-yl]-[3-(1-methyl-piperidin-4-yl)-propyl]-amine. MS: mass calcd. for C22H26F4N6, 450.22; m/z found, 451.2 [M+H]+. Example 29. [5-(4.6-Dichloro-1 H-benzoimidazol-2-yl)4-trifluoromethyl-pyrimidin- 2-yl]-[3-(1-methyl-piperidin-4-yl)-propyl]-amine. MS: mass calcd. for C21H23CI2F3N6,486.13; m/z found, 487.1 [M+H]+. Example 30. [5-(4.5-Dimethyl-1 H-benzoimidazol-2-yl)-4-trifluoromethyl-Pyrimidin- 2-yl]-[3-(1-methyl-p\|perldin-4-yl)propyl]-amine. MS: mass calcd. for C23H29F3N6, 446.24; m/z found, 447.3 [M+H]+. Example 31. [5-(5.6-Difluoro-1H-benzoimldazol-2-yl)4-trifluoromethyl-pyrimidin- 2-yl]-[3-(1-methyl-piperidin-4-yl)-propyl)-amine. MS: mass calcd. for C21H23F5N6, 454.19; m/z found, 455.2 [M+H]+. Example 32. [5-(4.5-Diftuoro-1 H-benzoimidazol-2-yl)4-isopropyl-pyrimidin-2-yl]- [3-(1-methyl-piperidin-4-yl)-propyl]-amine. MS: mass calcd. for C23H30F2N6, 428.25; m/z found, 429.3 [M+H]+. Example 33. [5-(5-Fluoro-4-methyl-1 H-benzoimidazol-2-yl)-pyrazin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine. Step A: 5-[3-(1 -methyl-Piperidin-4-yl)- propylaminol-Pyrazine-2-carboxylic acid methyl ester. A solution of 5-chloro-pyrazine-2-carboxylic acid methyl ester (1 equiv.) and 3-(1-methyl-piperidin-4-yl)-propylamine (1.1 equiv.) in MeOH (0.25 M) heated at 100 °C in a sealed tube for 4 h. The mixture was cooled to rt and concentrated to give a crude product which was purified by FCC. Step B; 5-[3-(1-Methyl-piperidin-4-yl)-prropylaminol-pyrazine-2- carbaldehyde. A -78 °C solution of 5-[3-(1-methyl-piperidin-4-yl)-propylamino]- pyrazine-2-carboxylic acid methyl ester in DCM (0.1 M) was treated with diisobutylaluminum hydride (1 M in hexanes; 1 equiv.) dropwise. The reaction was quenched with 1 M H2SO4, neutralized with satd. aq. NaHCO3, and diluted with MeOH, CHCI3, and satd. aq. sodium potassium tartrate. The mixture was stirred vigourously until the layers separated. The organic layer was dried (Na2SO4) and concentrated to give the crude product, which was used in the next step without further purification. Step C. The title compound was prepared using methods analogous to those described in Example 1, Step E, Part 2, to provide the title compound. MS: mass calcd. for C21H27FN6, 382.23; m/z found, 383.2 [M+H]+. Example 34. [5-(4.5-Dimethyl-1H-benzoimidazol-2-yl)pyrazin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine. The title compound was prepared using methods analogous to those described in Example 33. MS: mass calcd. for C22H30N6, 378.25; m/z found, 379.3 [M+H]+. The compounds in Examples 35-50 were prepared using methods analogous to those described in the preceding examples. Example 35. [5-(4.6-Bis-trifluoromethyl-1H-benzoimidazol-2-yl)-4-methyl- pyrimidin-2-yl]-[3-(1-methyl-Piperidin-4-yl)-propyl]-amine. MS (ESI): mass calcd. for C23H26F6N6. 500.49; m/z found, 501.2 [M+H]+. Example 36. 244-methyl-2-[3-(1-methyl-piperidin-4-yl)-propylamino]-pyrimidin-5- yl}-1H-benzoimidazole-5-carbonitrile. MS (ESI): mass calcd. for C22H27N7, 389.51; m/z found, 390.3 [M+H]. 1H NMR (MeOD): 8.55 (s, 1H), 7.99 (dd, J = 1.3, 0.5 Hz, 1H), 7.72 (dd, J = 8.3, 0.5 Hz. 1H), 7.57 (dd, J = 8.4, 1.5 Hz, 1H), 3.43 (t, J = 6.8 Hz, 2H), 2.89 (d, J = 12.1 Hz, 2H), 2.62 (s, 3H), 2.28 (s, 3H), 2.05 (t, J = 11.8 Hz, 2H), 1.76 (d, J = 11.3 Hz, 2H), 1.66 (td, J = 14.7, 7.5 Hz, 2H), 1.30 (m. 5H). Example 37. [5-(5-Methoxy-1 H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1 - methyl-piperidin-4-yl]-propyl]-amine. MS (ESI): mass calcd. for C22H30N6O, 394.52; m/z found, 395.3 [M+H]+. 1H NMR (MeOD): 8.45 (s, 1H), 7.46 (s, J = 8.8 Hz, 1H), 6.90 (dd, J = 8.8, 2.4 Hz, 1H), 7.09 (s, 1H), 3.85 (s, 3H), 3.42 (t, J - 7.1 Hz, 2H), 2.88 (d, J = 11.9 Hz, 2H). 2.56 (s, 3H), 2.27 (s, 3H), 2.03 (t, J = 11.7 Hz, 2H), 1.75 (d, J = 12.7 Hz, 2H), 1.66 (td, J = 15.0, 7.6 Hz, 2H), 1.38-1.20 (m. 5H). Example 38. [5-(4-Chloro-6-trifluoromethyl-1H-benzolmidazol-2-yl)4-methyl- pyrimidin-2-yl]-[3-(1-methyl-piperidin-4-yl)-propyl]-amine. MS (ESI): mass calcd. for C22H26CIF3N6, 466.94; m/z found, 467.2 [M+H]+. 1H NMR (MeOD): 8.55 (s, 1H), 7.83 (s, 1H), 7.55-7.53 (m, 1H), 3.43 (t, J = 6.9 Hz, 2H), 2.88 (d, J = 11.9 Hz, 2H), 2.61 (s, 3H), 2.27 (s, 3H), 2.04 (t, J = 11.8 Hz, 2H), 1.75 (d, J= 12.0 Hz, 2H), 1.66 (m,2H), 1.38-1.18 (m, 5H). Example 39. [5-[5-Chloro-6-fluoro-1H-benzoirnidazol-2-yl)-4-methyl-pyrimidin-2- yl]-[3-(1-methyl-piperidin-4-yl)-propyl]-amine. MS (ESI): mass calcd. for C21H26CIFN6, 416.93; m/z found, 417.2 [M+H]+. 1H NMR (MeOD): 8.49 (s, 1H), 7.67 (d, J = 6.6 Hz, 1H), 7.44 (d, J = 9.3 Hz, 1H), 3.42 (t, J = 7.0 Hz, 2H), 2.87 (d, J = 11.9 Hz, 2H), 2.58 (s, 3H), 2.25 (s, 3H). 2.01 (t, J = 12.7 Hz, 2H), 1.74 (d, J = 12.1 Hz. 2H), 1.65 (dd, J = 14.8, 7.2 Hz, 2H), 1.41-1.16 (m,5H). Example 40. [5-[5-Chloro-1 H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1 - methyl-piperidin-4-yl)-propyl]-amine. MS (ESI): mass calcd. for C21H27CIN6, 398.94; m/z found, 399.2 [M+H]+. 1H NMR (MeOD): 8.49 (s, 1H), 7.59 (d, J = 1.8 Hz, 1H), 7.55 (d, J = 8.6 Hz, 1H), 7.25 (dd, J - 8.6, 2.0 Hz, 1H), 3.42 (t, J = 6.9 Hz, 2H), 2.87 (d, J = 12.0 Hz, 2H), 2.58 (s, 3H), 2.26 (s, 3H), 2.02 (t, J - 11.7 Hz, 2H), 1.75 (d, J = 12.1 Hz, 2H), 1.65 (td, J = 14.8, 7.4 Hz, 2H), 1.38-1.19 (m, 5H). Example 41. [5-(5.6-Dichloro-1H-benzoimidazol-2-yl)-4-methyl-pvrlmidin-2-vl]-[3- (1 -methyl-piperidin-4-yl)-propyll-amine. MS (ESI): mass calcd. for C21H26CI2N6.433.39; m/z found, 433.2 [M+H]+. 1H NMR (MeOD): 8.50 (s, 1H), 7.74 (s, 2H), 3.43 (t, J = 7.1 Hz, 2H), 2.93 (d, J = 11.6 Hz, 2H), 2.59 (s, 3H), 2.31 (s, 3H), 2.11 (t, J = 11.3 Hz, 2H), 1.78 (d. J = 12.4 Hz, 2H). 1.66 (m, 2H), 1.33 (m, 6H). Example 42. [5-(4.6-Dimethyl-1 H-benzoimidazol-2-yl]-4-ethyl-pyrimidin-2-yl]-[3- (1-methyl-piperidin-4-yl)-propyl]-amine. MS (ESI): mass calcd. for C24H34N6, 406.58; m/z found, 407.3 [M+H]+. 1H NMR (MeOD): 8.36 (s, 1H), 7.19 (s, 1H), 6.89 (s, 1H), 3.46-3.39 (m, 2H), 2.88 (dd, J = 15.1, 7.8 Hz, 4H), 2.54 (s, 3H), 2.42 (s, 3H), 2.26 (s, 3H), 2.01 (t, J = 10.9 Hz, 2H), 1.74 (d, J - 11.9 Hz, 2H), 1.66 (dd, J = 14.4, 7.2 Hz. 2H), 1.26 (m, 8H). Example 43. [4-ethyl-5-(4-methyl-1H-benzoimidazol-2-yl)- pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine. MS (ESI): mass calcd. for C23H32N6,392.55; m/z found, 393.3 [M+H]+. 1H NMR (MeOD):.8.39 (s, 1H), 7.41 (d, J = 7.1 Hz, 1H), 7.15 (t, J = 7.7 Hz, 1H), 7.05 (d, J = 7.3 Hz, 1H), 3.44 (t, J = 5.2 Hz, 2H), 2.89 (s, 4H), 2.58 (s, 3H), 2.27 (s, 3H), 2.03 (t, J = 11.7 Hz, 2H), 1.75 (d, J = 12.4 Hz, 2H), 1.67 (td, J = 14.9, 7.3 Hz, 2H), 1.41-1.12 (m,8H). Example 44. [4-Cyclopropyl-5-(4-methyl-1 H-benzoimidazol-2-yl)-pyrimidin-2-yl]- [3-(1-methyl-piperidin-4-yl)-propyl]-amine. MS (ESI): mass calcd. for C24H32N6,404.56; m/z found, 405.3 [M+H]+. 1H NMR (MeOD): 8.32 (s. 1H), 7.41 (d, J = 6.5 Hz, 1H), 7.17-7.12 (m. 1H), 7.05 (d, J = 7.3 Hz, 1H), 3.39-3.34 (m, 2H), 2.89 (d, J = 12.0 Hz, 2H), 2.59 (s, 3H), 2.47 (s, 1H), 2.28 (s, 3H), 2.05 (t, J = 11.6 Hz, 2H), 1.75 (d, J = 12.0 Hz, 2H). 1.67-1.58 (m, 2H), 1.38-1,17 (m, 7H), 1.02 (dd, J = 7.3, 3.0 Hz. 2H). Example 45. r4-Cyclopropyl-5-(4.5-dimethyl-1 H-benzoimidazol-2-yl)-pyrimidin-2- yl]-[3-(1-methyl-piperidin-4-yl]-propyl]-amine. MS (ESI): mass calcd. for C25H34N6, 418.59; m/z found, 419.3 [M+H]+. 1H NMR (MeOD): 8.31 (s, 1H), 7.31 (d, J = 7.2 Hz, 1H), 7.06 (d, J = 8.2 Hz, 1H), 3.36 (t, J = 7.1Hz, 2H), 2.88 (d. J = 12.0 Hz. 2H), 2.56-2.42 (m, 4H), 2.39 (s, 3H), 2.27 (S, 3H), 2.03 (t, J = 11.6 Hz, 2H), 1.74 (d, J = 11.7 Hz, 2H), 1.62 (td, J = 14.7, 7.5 Hz, 2H), 1.38-1.16 (m, 7H), 1.01 (dd, J = 7.5, 3.1 Hz, 2H). Example 46. [4-Cyclopropyl-5-(6-fluoro-4-methyl-1H-benzoimidazol-2-yl)- pyrimidin-2-yl]-[3-(1-methyl-piperidin-4-yl)-propyl]-amine. MS (ESI): mass calcd. for C24H31FN6, 422.55; m/z found, 423.3 [M+H]+. 1H NMR (MeOD): 8.32 (s, 1H), 7.10 (d, J = 8.0 Hz, 1H), 6.86 (dd, J = 10.5,1.5 Hz, 1H), 3.36 (t, J = 7.3 Hz, 2H), 2.91 (d, J = 12 1 Hz, 2H), 2.59 (s, 3H), 2.48 (s, 1H), 2.29 (s, 3H), 2.07 (t, J = 10.8 Hz, 2H), 1.76 (d, J = 12.3 Hz, 2H), 1.62 (dd. J = 14.3, 7.4 Hz, 2H), 1.40-1.17 (m. 7H), 1.05-0.98 (m, 2H). Example 47. [4-Cyclopropyl-5-(4.6-dimethyl- 1H-benzoimidazol-2-yl))-pyrimidin-2- yl1-[3-(1-methyl-piperidin-4-yl)-propyl]-amine MS (ESI): mass calcd. for C26H34N6, 418.59; m/z found, 419.3 [M+H]+. 1H NMR (MeOD): 8.30 (s, 1H), 7.20 (s, 1H), 6.89 (s, 1H), 3.36 (t. J = 7.0 Hz, 2H), 2.88 (d, J - 11.5 Hz, 2H). 2.54 (s, 3H), 2.46 (s, 1H), 2.42 (s, 3H), 2.27 (s, 3H), 2.03 (t, J = 11.0 Hz, 2H), 1.74 (d, J = 11.4 Hz, 2H), 1.66-1.57 (m, 2H), 1.38-1.16 (m,7H), 1.04-0.98 (m,2H). Example 48. [4-Cyclopropyl-5-(5-fluro-4-methyl-1H-benzoimidazol-2-yl)- pyrimidin-2-yl]-[3-1-methyl-piperidin-4-yl)propyl]-amine. MS (ESI): mass calcd. for C24H31FN6,422.55; m/z found, 423.3 [M+H]+. 1H NMR (MeOD): 8.33 (s, 1H), 7.38 (s, 1H), 7.01 (dd, J = 10.3, 8.8 Hz, 1H), 3.37 (t, J = 7.0 Hz, 1H), 2.91 (d, J = 11.9 Hz, 2H), 2.54-2.43 (m, 4H), 2.30 (s. 3H), 2.08 (t, J = 10.9 Hz, 2H), 1.94 (s, 1H), 1.76 (d, J = 12.4 Hz, 2H), 1.68-1.59 (m, 2H), 1.42- 1.17 (m, 7H), 1.06-1.00 (m, 2H). The compounds In Examples 49-50 are prepared using methods analogous to those described in the preceding examples. Example 49. [5-(6-Chloro-5-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2- yl]-[3-( 1 -methyl-piperidin-4-yl)-propyl]-amine. Example 50. [5-(4-Chloro-6-methyl-1 H-benzoimidazol-2-yl]-4-methyl-pyrimidin-2- yl]-[3(1-methyl-piperidin-4-yl]-propyl]-amine Additional examples of embodiments of this invention are provided by hemitartrate salts of compounds of Formula (I) and by hydrates, such as monohydrates and dehydrates, of compounds of Formula (I). For example, embodiments of this invention include monohydrates of, dihydrates of, and/or hemitartrate salts of compounds selected from the group consisting of: [5-(5-Fluoro-4-methyl-1 H-benzoimidazol -2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1 - methyl-piperidin-4-yl)-propyl]-amine; [5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyI]-amine; [5-(6-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Difluoro-1H-benzoimidazol-2-yl)-4 methyl-pyrimidin-2-yl]-[3-(1 -methyl- piperidin-4-yl)-propyl]-amine; [5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperid in-4-yl)-propyl]-amine; [5-(4,6-Difluoro-1H-benzoimIdazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperid in-4-yl)-propyl]-amine; [5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4methy-pyrimidin-2-yl]-methyl-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-ethyl-pyrimidin-2-yl]-methyl-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Drfluoro-1H-benzoimidazol-2-yl)-4-ethyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(4-Fluoro-5-methyl-1H-benzoimidazol-2-yl)-4-propyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Dimethyl-1H-benzofmidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(4,6-DimethyI-1H-benzoimidazol-2-yl)-4-isiopropyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [4-Cyclobutyl-5-(4l5-dimethyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [4-Cyclobutyl-6-(4,5-difluoro-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(5-Fluoro-4-methyl-1 H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-( 1 -methyl- piperidin-4-yl)-propyl]-amine; [4-Cyclobutyl-5-(5-fluoro-4-methyl-1H-benzoirnidazol-2-yl)-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [4-Cyclobutyl-5-(4f6-dimethyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-propyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [4-Ethyl-5-(5-fluoro-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(5-Fluoro-4-methyl-1 H-benzoimidazol-2 -yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1 - methyl-piperidin-4-yl)-propyl]-amine; [4-Methyl-5-(4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(1H-Benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-piperidin-4-yl)- propyl]-amine; [5-(5-Fluoro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [3-(1-Methyl-piperidin-4-yl)-propyl]-[4-methyl-5-(5-trifluoromethyl-1H- benzoimidazol-2-yl)-pyrimidin-2-yl]-amine; [5-(5-tert-Buty)-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(5-Chloro-4-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(5-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3- (1-methyl-piperidin-4-yl)-propyl]-amine; [5-(6-Fluoro-4-methyl-1H-benzoimidazol-2 -yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3- (1-methyl-piperidin-4-yl)-propyl]-amine; [5-(4,6-Dichloro-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Dimethyl-1 H-benzoimidazol-2-yl)-4 trifluoromethyl-pyrimidin-2-yl]-[3-(1 - methyl-piperidin-4-yl)-propyl]-amine; [5-(5,6-Difluoro-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Difluoro-1 H-benzoimidazol-2-yl)-4- isopropyl-pyrimidin-2-yl]-[3-(1 -methyl- piperidin-4-yl)-propyl]-amine; [5-(1H-Benzoimidazol-2-yl)-pyrazin-2-yl]-[3-(1-methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-pyrazin-2-yl]-[3-(1 -methyl-piperidin-4-yl)- propyl]-amine; [5-(4,6-Bis-trifluoromethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-( 1 - methyl-piperidin-4-yl)-propyl]-amine; 2-{4-Methyl-2-[3-(1-methyl-piperidin-4-yl)-propylamino]-pyrimidin-5-yl}-l H- benzoimidazole-5-carbonitrile; [5-(5-Methoxy-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(4-Chloro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3- (1-methyl-piperidin-4-yl)-propyl]-amine; [5-(5-Chloro-6-fluoro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(5-Chloro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(5,6-Dichloro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4-ethyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yI)-propyI]-amine; [4-Ethyl-5-(4-methyl-1 H-benzoimidazol-2-yl )-pyrimidin-2-yl]-[3-(1 -methyl-piperidin- 4-yl)-propyl]-amine; [4-Cyclopropyl-5-(4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [4-Cyclopropyl-5-(4,5-dimethyl-1H-benzoimidazol-2-yI)-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [4-Cyclopropyl-5-(6-fluoro-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [4-CycIopropyl-5-(4,6-dimethyl-1H-benzoimldazol-2-yl)-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [4-Cyclopropyl-5-(5-fluora-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(6-Chloro-5-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; and [5-(4-Chloro-6-methyl-1H-benzoimidiazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine. Biological Testing: Binding Assay on Recombinant Human Histamine H4 Receptor SK-N-MC cells or COS7 cells were transiently transfected with pH4R and grown in 150 cm2 tissue culture dishes. Cells were washed with saline solution, scraped with a cell scraper and collected by centrifugation (1000 rpm, 5 min). Cell membranes were prepared by homogenization of the cell pellet in 20 mM Tris-HCI with a polytron tissue homogenizes for 10 sec at high speed. Homogenate was centrifuged at 1000 rpm for 5 min at 4 °C. The supernatant was then collected and centrifuged at 20,000 x g for 25 min at 4 °C. The final pellet was resuspended in 50 mM Tris-HCI. Cell membranes were incubated with 3H-histamine (5-70 nM) in the presence or absence of excess histamine (10,000 nM). Incubation occurred at room temperature for 45 min. Membranes were harvested by rapid filtration over Whatman GF/C filters and washed 4 times with ice-cold 50 mM Tris HCI. Filters were then dried, mixed with scintillant and counted for radioactivity. SK-N-MC or COS7 cells expressing human histamine H4 receptor were used to measure the affimity of binding of other compounds and their ability to displace 3H-ligand binding by incubating the above-described reaction in the presence of various concern rations of inhibitor or compound to be tested. For competition binding studies using 3H-histamine, K1 values were calculated, based on an experimentally determined KD value of 5 nM and a ligand concentration of 5 nM, according to Y.-C. Cheng and W.H. Prusoff (Biochem. Pharmacol. 1973, 22(23):3099-3108): K1 = (IC50)/(1 + ([L]/(KD)). Results for the compounds tested in this assay are presented in Table 1 as an average of results obtained, and rounded to the nearest 10 nM. Table 1 While the invention has been illustrated by reference to examples, it is understood that the invention is intended not to be limited to the foregoing detailed description. What is claimed is: 1. A chemical entity that is a compound of Formula (I): wherein each of R1-4 is independently H, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, phenyl, -CF3, - OCF3, -CN, halo, -NO2. -OC1-4alkyl, -SC1-4alkyl, -S(O)C1-4alkyl, -SO2C1-4alkyl, -C(O)C1-4alkyl, -C(O)phenyl, -C(O)NRaRb, -CO2C1-4alkyl, -CO2H, -C(O)NRaRb, or-NRaRb; wherein Ra and Rb are each independently H, C1-4alkyl, or C3-7cycloalkyl; one of X1 and X2 is N and the other is C-Rc; where Rc is H, methyl, hydroxymethyl, dimethylaminomethyl, ethyl, propyl, isopropyl, -CF3, cyclopropyl, or cyclobutyl; n is 1 or 2; Z is N, CH, or C(C1-4alkyl); R6 is H, C1-6alkyl, or monocyclic cycloalkyl; R8 is H or C1-4alkyl; R9 and R10 are each independently H or C1-4alkyl; and R11 is H or C1-4alkyl; a pharmaceutically acceptable salt of compound of Formula (I), a pharmaceutically acceptable prodrug of compound of Formula (I), or a pharmaceutically active metabolite of compound of Formula (I). 2. A chemical entity as defined in claim 1, wherein each of R1-4 is independently H, methyl, tert-butyl, methoxy, -CF3, -CN, fluoro, chloro, methoxycarbonyl, or benzoyl. 3. A chemical entity as defined in claim 1, wherein X2 is N. 4. A chemical entity as defined in claim I, wherein X1 is N. 5. A chemical entity as defined in ciiaim 1, wherein Rc is H, methyl, ethyl, CF: cyclopropyl, or cyclobutyl. 6. A chemical entity as defined in claim 1, wherein Rc is H or methyl. 7. A chemical entity as defined in claim 1, wherein n is 1. 8. A chemical entity as defined in claim 1, wherein Z is N or CH. 9. A chemical entity as defined in claim 1, wherein Z is CH. 10. A chemical entity as defined in claim 1, wherein R6 is H, methyl, ethyl, propyl, isopropyl, cyclopropyl, or cyclobutyl. 11. A chemical entity as defined in claim 1, wherein R6 is H or methyl. 12. A chemical entity as defined in claim 1, wherein R8 is H. 13. A chemical entity as defined in claim 1, wherein R9 and R10 are each independently H or methyl. 14. A chemical entity as defined in claim 1, wherein R9 and R10 are both H. 15. A chemical entity as defined in claim 1, wherein R11 is H or methyl. 16. A chemical entity as defined in claim 1, wherein R11 is methyl. 17. A chemical entity selected from: [5-(5-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidon-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(6-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-methyl-Pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Difluoro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(4,5-Dimethyl-1H-benzoimldazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(4,6-Difluoro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(4,6-Dimethyl-1 H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-methyl-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Dimethyl-1 H-benzoimidazol-2-yl)-4- ethyl-pyrimidin-2-yl]-methyl-[3-(1 - methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Difluoro-1H-benzoirnidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(4-Fluoro-5-methyl-1H-benzoimidazol-2-yl)-4-propyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(4,6-Dimethyl-1 H-benzoimidazol-2-yl)-4- isopropyl-pyrimidin-2-yl]-[3-(1 -methyl- piperidin-4-yl)-propyl]-amine; [4-Cyclobutyl-5-(4,5-dimethyl-1H-benzoimiclazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [4-Cyclobutyl-5-(4,5-difluoro-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(5-Fluoro-4-methyl-1H-benzoimldazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [4-Cyclobutyl-5-(5-fluoro-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [4-Cyclobutyl-5-(4,6-dimethyl-1 H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1 -methyl- piperidin-4-yl)-propyl]-amine; [5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-propyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl)-amine; t4-Ethyl-5-(5-fluoro-4-methyl-1H-benzoimiclazol-2-yl)-pyrimidin-2-yl]-(3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(5-Fluoro-4-methyl-1 H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1 - methyl-piperidin-4-yl)-propyl]-amine; [4-Methyl-5-(4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl](-amine; [5-(1 H-Benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-( 1 -methyl-piperidin-4-yl)- propyl]-amine; [5-(5-Fluoro-1H-benzoimidazol-2-yl)-4-methyl,-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [3-(1 -Methyl-piperidin-4-yl)-propyl]-[4-methyl-5-(5-trifluoromethyI-1 H- benzoimidazol-2-yl)-pyrimidin-2-yl]-amine; [5-(5-tert-Butyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(5-Chloro-4-methyl-1 H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-( 1 - methyl-piperidin-4-yl)-propyl]-amine; [5-(5-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3- (1-methyl-piperidin-4-yl)-propyl]-amine; [5-(6-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3- (1-methyl-piperidin-4-yl)-propyl]-amine; [5-(4,6-Dichloro-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(5,6-Difluoro-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Difluoro-1H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(1H-Benzoimidazol-2-yl)-pyrazin-2-yl]-[3-(1-methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Dimethyl-1H-benzoimidazol-2-yl;)-pyrazin-2-yl]-[3-(1-methyl-piperidin-4-yl)- propyl]-amine; and pharmaceutically acceptable salts thereof. 18. A chemical entity as defined in claim 1, wherein said chemical entity is a compound of Formula (I) or a pharmaceutically acceptable salt of said compound of Formula (I). 19. A pharmaceutical composition for treating a disease, disorder, or medical condition mediated by histamine H4 receptor activity, comprising an effective amount of at least one agent selected from compounds of Formula (I): wherein each of R1-4 is independently H, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, phenyl, -CF3, - OCF3( -CN, halo, -NO2, -OC1-4alkyl, -SC1-4alkyl, -S(O)C1-4alkyl, -SO2C1-4alkyl, -C(O)C1-4alkyl, -C(O)phenyl, -C(O)NRaRb, -CO2C1-4alkyl, -CO2H, -C(O)NRaRb, or-NRaRb; wherein Ra and Rb are each independently H, C1-4alkyl, or C3-7cycloalkyl; one of X1 and X2 is N and the other is C-Rc; where Rc Is H, methyl, hydroxymethyl, dimethylaminomethyl, ethyl, propyl, isopropyl, -CF3, cyclopropyl, or cyclobutyl; n is 1 or 2; Z is N, CH, or C(C1-4alkyl); R6 is H, C1-6aikyl, or monocyclic cycloalkyl; R8 is H or C1-4alkyl; R9 and R10 are each independently H or C1-4alkyl; and R11 is H or C1-4alkyl; pharmaceutically acceptable salts of compounds of Formula (I), pharmaceuticaily acceptable prodrugs of compounds of Formula (I), and pharmaceuticaily active metabolites of compounds of Formula (I]. 20. A pharmaceutical composition according to claim 19, wherein said at least one agent is selected from: [5-(5-Fluoro-4-methyt-1H-benzoimidazol-2-yl)-4-methy-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(6-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Difluoro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(4,6-Difluoro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-methyl-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Dimethyl-1 H-benzoimidazol-2-yl)-4-ethyl-pyrimidin-2-yl]-methyl-[3-(1 - methyl-piperldin-4-yl)-propyl]-amine; [5-(4,5-Difluoro-1H-benzoimidazol-2-yl)-4-ethyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(4-Fluoro-5-methyl-1H-benzoimidazol-2-yl)-4-propyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Dlmethyl-1 H-benzoimidazol-2-yl)-4-lsopropyl-pyrimidin-2-yl]-[3-( 1 -methyl- piperidin-4-yl)-propyl]-amine; [5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [4-Cyclobutyl-5-(4,5-dimethyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-( 1 -methyl- piperidin-4-yl)-propyl]-amine; [4-Cyclobutyl-5-(4,5-difluoro-1H-benzoimida2ol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(5:Fluoro-4-methyl-1 H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-( 1 -methyl- piperidin-4-yl)-propyl]-amine; [4-Cyclobutyl-5-(5-fluoro-4-methyl-1H-berizoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [4-Cyclobutyl-5-(4,6-dimethyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- piperid in-4-yl)-propyl]-amine; [5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-propyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [4-Ethyl-5-(5-fluoro-4-methyl-1H-benzoirnidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(5-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [4-Methyl-5-(4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(1H-Benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-piperidin-4-yl)- propyl]-amine; [5-(5-Fluoro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [3-(1-Methyl-piperldin-4-yl)-propyl]-[4-methyl-5-(5-trifluoromethyl-1H- benzoimidazol-2-yl)-pyrimidin-2-yl]-amine; [5-(6-tert-Butyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(5-Chloro-4-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(5-Fluoro-4--methyl-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3- (1-methyl-piperidin-4-yl)-propyl]-amine; [5-(6-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3- (1-methyl-piperidin-4-yl)-propyl]-amine; [5-(4,6-Dichloro-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4"trifluoromethyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(5,6-Difluoro-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Difluoro-1H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(1 H-Benzoimidazol-2-yl)-pyrazin-2-yl]-[3 -(1 -methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-pyrazin-2-yl]-[3-(1-methyl-piperidin-4-yl)- propyl]-amine; and pharmaceutically acceptable salts thereof. 21. A method of treating a subject suffering from or diagnosed with a disease, disorder, or medical condition mediated by histamine H4 receptor activity, comprising administering to a subject in need of such treatment an effective amount of at least one agent selected from compounds of Formula (I): wherein each of R1-4 is independently H, C1-4alky I, C2-4alkenyl, C2-4alkynyl, phenyl, -CF3. - OCF3, -CN, halo, -NO2, -OC1-4alkyl, -SC1-4alkyl, -S(O)C1-4alkyl, -SO2C1-4alkyl, -C(O)C1-4alkyl, -C(O)phenyl, -C(O)NRaRb, -CO2C1-4alkyl. -CO2H, -C(O)NRaRb, or-NRaRb; wherein Ra and Rb are each independently H, C1-4alkyl, or C3-7cycloalkyl; one of X1 and X2 is N and the other is C-Rc; where Rc is H, methyl, hydroxymethyl, dimethylaminomethyl, ethyl, propyl, isopropyl, -CF3, cyclopropyl, or cyclobutyl; n is 1 or 2; Z is N, CH, or C(C1-4alkyl); R6 is H, C1-6alkyl, or monocyclic cycloalkyl; R8 is H or C1-4alkyl; R9 and R10 are each independently H or C1-4alkyl; and R11 is H or C1-4alkyl; pharmaceutically acceptable salts of compounds of Formula (I), pharmaceutically acceptable prodrugs of compounds of Formula (I), and pharmaceutically active metabolites of compounds of Formula (I). 22. A method according to claim 21, wherein said at least one agent is selected from: [5-(5-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,6-Dimethyl-1H-benzolmidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(6-Fluoro-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Difluoro-1H-benzoimidazol-2-yl)-4-methy\|-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(4,5-Dimemyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(4,6-Difluoro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-methyl-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Dimethyl-1 H-benzoimidazol-2-yl)-4-ethyl-pyrimidin-2-yl]-methyl-[3-( 1 - methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Difluoro-1 H-benzoimidazol-2-yl)-4-ethyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyrl]-amine; [5-(4-Fluoro-5-methyl-1H-benzoimidazol-2-yl)-4-propyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [4-Cyclobutyl-5-(4,5-dimethyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [4-Cyclobuty1-5-(4,5-difluoro-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(5-Fluoro-4-methyl-1H-benzoimidazol-;2-yl)-pyrimidin-2-y)]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [4-Cyclobutyl-5-(5-fluoro-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [4-Cyclobutyl-5-(4,6-dimethyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-propyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [4-Ethyl-5-(5-fluoro-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- p)peridin-4-yl)-propyl]-amine; [5-(5-Fluoro-4-methyl-1H-benzoimidazoI-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [4-Methyl-5-(4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(1H-Benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-piperidin-4-yl)- propyl]-amine; [5-(5-Fluoro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [3-(1-Methyl-piperidin-4-yl)-propyl]-[4-methyl-5-(5-trifluoromethyl-1H- benzoimidazol-2-yl)-pyrimidin-2-yl]-amine; [5-(5-tert-Butyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(5-Chloro-4-methyl-1 H-benzoimidazol-2- yl)-4-methyl-pyrimldin-2-yl]-[3-( 1 - methyl-piperidin-4-yl)-propyl]-amine; [5-(5-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3- (1 -methyl-piperidin-4-yl)-propyl]-amine; [5-(6-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-trifluoromethyl-pyrimidin-2-yl-[3- (1 -methyl-piperidin-4-yl)-propyl]-amine; [5-(4,6-Dichloro-1H-benzoimida20l-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(5,6-Difluoro-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-(1- methy\|-piperidin-4-yl)-propyl]-amine; [5-(4,5-Difluoro-1H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(1H-Benzoimidazol-2-yI)-pyrazin-2-yl]-[3-(1-methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-pyrazin-2-yl]-[3-(1-methyl-piperidin-4-yl)- propyl]-amine; and pharmaceutically acceptable salts thereof 23. A method according to claim 21, wherein the disease, disorder, or medical condition is inflammation. 24. A method according to claim 21, wherein the disease, disorder, or medical condition is selected from the group consisting of: Inflammatory disorders, allergic disorders, dermatological disorders, autoimmune disease, lymphatic disorders, and immunodeficiency disorders 25. A method according to claim 21, wherein the disease, disorder, or medical condition is selected from: allergy, asthma, dry eye, chronic obstructed pulmonary disease (COPD), atherosclerosis, rheumatoid arthritis, multiple sclerosis, inflammatory bowel diseases, colitis, Crohn's disease, ulcerative colitis, psoriasis, pruritis, itchy skin, atopic dermatitis, urticaria, hives, ocular inflammation, conjunctivitis, nasal polyps, allergic rhinitis, nasal itch, scleroderma, autoimmune thyroid diseases, immune-mediated diabetes mellitus, lupus, Myasthenia gravis, autoimmune neuropathies, Guillain-Barr6, autoimmune uveitis, autoimmune hemolytic anemia, pernicious anemia, autoimmune thrombocytopenia, temporal arteritis, anti-phosphollpid syndrome, vasculltides, Wegener's granulomatosis, Behcet's disease, dermatitis herpetiformis, pemphigus vulgaris, vitiligio, primary biliary cirrhosis, autoimmune hepatitis, autoimmune oophoritis, autoimmune orchitis, autoimmune disease of the adrenal gland, polymyositis, dermatomyositis, spondyloarthropathies, ankylosing spondylitis, and Sjogren's syndrome. 26. A method according to claim 21, wherein the disease, disorder, or medical condition is selected from: allergy, asthma, autoimmune diseases, and pruritis. 27. A method for modulating histamine H4 receptor activity, comprising exposing histamine H4 receptor to an effective amount of at least one agent selected from a compound of Formula (I): wherein each of R1-4 is independently H, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, phenyl, -CF3, - OCF3, -CN. halo. -NO2, -OC1-4alkyl, -SC1-4alkyl, -S(O)C1-4alkyl, -SO2C1-4alkyl, -C(O)C1-4alkyl, -C(O)phenyl, -C(O)NRaRb, -CO2C1-4alkyl, -CO2H, -C(O)NRaRb, or -NRaRb; wherein Ra and Rb are each independently H, C1-4alkyl, or C3-7cycloalkyl; one of X1 and X2 is N and the other is C-Rc; where Rc is H, methyl, hydroxymethyl, climethylaminomethyl, ethyl, propyl, isopropyl, -CF3, cyclopropyl, or cyclobutyl; n is 1 or 2; Z is N, CH, or C(C1-4alkyl); R6 is H, C1-6alkyl, or monocyclic cycloalkyl; R8 is H or C1-4alkyl; R9 and R10 are each independently H or C1-4alkyl; and R11 is H or C1-4alkyl; and a salt of a compound of Formula (I). 28. A method according to claim 27, wherein said at least one agent is one of. I5-(6-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-methyl,-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,6-Dimethyl-1H-benzoimida2ol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyll-amine; [5-(6-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1- methyi-piperidin-4-yl)-propyl]-amine; [5-(4,5-Difluoro-1 H-benzoimidazol-2-yl)-4- methyl-pyrimidin-2-yl]-[3-( 1 -methyl- piperidin-4-yl)-propyl]-amine; [5-(4,5-Dimethyi-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(4,6-Difluoro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(4,6-Dimethyl-1 H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-methyl-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-ethyl-pyrimidin-2-yl]-methyl-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Difluoro-1H-benzoimidazol-2-yl)-4-ethyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(4-Fluoro-5-methyl-1H-benzoimidazol-2-yl)-4-propyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Dimethyl-1 H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-( 1 -methyl- piperidin-4-yl)-propyl]-amine; [5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [4-Cyclobutyl-5-(4,5-dimethyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [4-Cyclobutyl-5-(4,5-difluoro-1 H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-( 1 -methyl- piperidin-4-yl)-propyl]-amine; [5-(5-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [4-Cyclobutyl-5-(5-fluoro-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [4-Cyclobutyl-5-(4,6-dimethyl-1 H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-( 1 -methyl- piperidin-4-yl)-propyl]-amine; [5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-propyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [4-Ethyl-5-(5-fluoro-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(5-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [4-Methyl-5-(4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(1H-Benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-piperidin-4-yl)- propyl]-amine; [5-(5-Fluoro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [3-(1-Methyl-piperidin-4-yl)-propyl]-[4-methyl-5-(5-trjfluoromethyl-1H- benzoimidazol-2-yl)-pyrimidin-2-yl]-amine [5-(5-tert-Butyl-1H-benzoimidazol-2-yI)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; l5-(5-Chloro-4-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(5-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3- (1-methyl-piperidin-4-yl)-propyl]-amine; [5-(6-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3- (1-methyl-piperidin-4-yl)-propyl]-amine; [5-(4,6-Dichloro-1 H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-( 1 - methyl-piperidin-4-yl)-propyl)-amine; [5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(5,6-Difluoro-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl)-amine; [5-(4,5-Difluoro-1 H-benzoimidazol-2yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(1H-Benzoimidazol-2-yl)-pyrazin-2-yl]-[3-(1-methyl-piperidin-4-yl)-propyll-amine; [5-(4,5-Dimethyl-1 H-benzoimidazol-2 -yl)-pyrazin-2-yl]-[3-( 1 -methyl-piperidin-4-yl)- propyl]-amine; and salts thereof. 29. A chemical entity selected from: [5-(4,6-Bis-trifluoromethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; 2-{4-Methyl-2-[3-( 1 -methyl-piperidin-4-yl)-propylamino]-pyrimidin-5-yl}-1 H- benzoimidazole-5-carbonitrile; [5-(5-Methoxy-1H-benzolmidazol-2-yl]-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl)-amine; [5-(4-Chloro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3- (1-methyl-piperidin-4-yl)-propyl]-amine; [5-(5-Chloro-6-fluoro-1H-benzoimidazol-2-yl]-[-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-{6-Chloro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(5,6-Dichloro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(4,6-Dimethyl-1 H-benzolmidazol-2-yl)-4-ethyl-pyrimidin-2-yl]-[3-(1 -methyl- piperidin-4-yl)-propyl]-amrne; [4-Ethyl-5-(4-methyl-1H-benzoimldazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-piperidin- 4-yl)-propyl]-amine; [4-Cyclopropyl-5-(4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [4-Cyclopropyl-5-(4,5-dimethyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [4-Cyclopropyl-5-(6-fluoro-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [4-Cyclopropyl-5-(4,6-dimethyl-1H-ben2oirniclazol-2-yl)-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [4-Cyclopropyl-5-(5-fluoro-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(6-Chloro-5-methyl-1 H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-( 1 - methyl-piperidin-4-yl)-propyl]-amine; [5-(4-Chloro-6-methyl-1H-benzoimidazol-2-yl]-[-methyl-pyrimidin-2-yl]-[3-{1- methyl-piperidin-4-yl)-propyl]-amine; and pharmaceutically acceptable salts thereof. 30. A pharmaceutical composition according to claim 19, wherein said at least one agent is selected from: [5-(4,6-Bis-trifluoromethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; 2-{4-Methyl-2-[3-(1-methyl-piperidin-4-yl)-propylamino]-pyrimidin-5-yl}-1H- benzoimidazole-5-carbonitrile; [5-(5-Methoxy-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperldin-4-yl)-propyl]-amine; [5-(4-Chloro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3- (1-methyl-piperidin-4-yl)-propyl]-amine; [5-(5-Chloro-6-fluoro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(5-Chloro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(5,6-Dichloro-1H-benzoimidazol-2-yl]-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4-ethyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [4-Ethyl-5-(4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-piperidin- 4-yl)-propyl]-amine; [4-Cyclopropyl-5-(4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [4-Cyclopropyl-5-(4,5-dimethy\|-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [4-Cyclopropyl-5-(6-fluoro-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [4-Cyclopropyl-5-(4,6-dimethyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1- nriethyl-piperidin-4-yl)-propyl]-amine; [4-Cyclopropyl-5-(5-fluoro-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(6-Chloro-5-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yI)-propyl]-amine; [5-(4-Chloro-6-methyl-1H-benzoimidazol-2-yl]-[-methyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; and pharmaceutically acceptable salts thereof. 31. A method according to claim 21, wherein said at least one agent is selected from: [5-(4,6-Bis-trifluoromethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; 2-{4-Methyl-2-[3-(1-methyl-piperidin-4-yl)-propylamino]-pyrimidin-5-yl}-1H- benzoimldazole-5-carbonitrile; [5-(5-Methoxy-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(4-chloro-6-trifluoromethyl-1H-benzoimiclazol-2-yl]-[-methyl-pyrimidin-2-yl]-[3- (1-methyl-piperidin-4-yl)-propyl]-amine; [5-(5-Chloro-6-fluoro-1H-benzoimldazol-2-yl]-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(5-Chloro-1 H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-( 1 -methyl- piperidin-4-yl)-propyl]-amine; [5-(5,6-Dichloro-1H-benzoimidazol-2-yl]-[-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4-ethyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [4-Ethyl-5-(4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-piperidin- 4-yl)-propyl]-amine; t4-Cyclopropyl-5-(4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [4-Cyclopropyl-5-(4,5-dimethyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [4-Cyclopropyl-5-(6-fluoro-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [4-Cyclopropyl-5-(4,6-dimethyl-1 H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-( 1 - methyl-piperidin-4-yl)-propyl]-amine; [4-Cyclopropyl-5-(5-fluoro-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(6-Chloro-5-methyl-1 H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1 - methyl-piperidin-4-yl)-propyl]-amine; [5-(4-Chloro-6-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1- methyt-piperidin-4-yl)-propyl]-amine; and pharmaceutically acceptable salts thereof. 32. A chemical entity that is a compound of Formula (I): wherein each of R1-4 is independently H, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, phenyl, -CF3, - OCF3, -CN, halo, -NO2, -OC1-4alkyl, -SC1-4alkyl, -S(O)C1-4alkyl, -SO2C1-4alkyl. -C(O)C1-4alkyl, -C(O)phenyl, -C(O)NRaRb, -CO2C1-4alkyl, -CO2H, -C(O)NRaRb. or -NRaRb; wherein Ra and Rb are each independently H, C1-4alkyl, or C3-7cycloalkyl; one of X1 and X2 is N and the other is C-Rc; where Rc is H, methyl, hydroxymethyl, dimethylaminomethyl, ethyl, propyl, isopropyl, -CF3, cyclopropyl, or cyclobutyl; n is 1 or 2; Z is N, CH, or C(C1-4alkyl); R6 is H, C1-6alky), or monocyclic cycloalkyl; R8 is H or C1-4alkyl; R9 and R10 are each independently H or C1-4alkyl; and R11 is H or C1-4alkyl; a monohydrate of a compound of Formula (I), a dihydrate of a compound of Formula (I), or a hemltartrate salt of a compound of Formula (I). 33. A chemical entity selected from: [5-(5-Fluoro-4-methyl-1H-benzoimidazol-2:-yl)-4-methyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(6-Fluoro-4-methyl-1 H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Difluoro-1H-benzoimidazol-2-yl)-4-methyl-pyrlmidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyr]-amine; [5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(4t6-Difluoro-1 H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-( 1-methyl- piperidin-4-yl )-propyl]-amine; [5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-methyl-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Dimethyl-1H-benzoimidazol-2-yl]-4-ethyl-pyrimidin-2-yl]-methyl-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Difluoro-1H-benzoimidazol-2-yl)-4-ethyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(4-Fluoro-5-methyl-1H-benzoimidazol-2-yl)-4-propyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-y\|)-propyl]-amine; [5-(4,6-Dimethyl-1H-benzoimidazol-2-yl]-[-isopropyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [4-Cyclobutyl-5-(4,5-dimethyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [4-Cyclobutyl-5-(4,5-difluoro-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yI)-propyl]-amine; [5-(5-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [4-Cyclobutyl-5-(5-fluoro-4-methyl-1H-benzoimidazoI-2-yl)-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [4-Cyclobutyl-5-(4,6-dimethyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methy)- piperidin-4-yI)-propyl]-amine; [5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-propyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [4-Ethyl-5-(5-fluoro-4-methyl-1H-benzoimdazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(5-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl]-propyl]-amine; [4-Methyl-5-(4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(1H-Benzojmidazof-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-piperidin-4-yl)- propyl]-amine; [5-(5-Fluoro-1H-benzoimidazol-2-yI)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [3-(1-Methyl-piperidin-4-yl)-propyl]-[4-methy)-5-(5-trifluoromethyl-1H- benzoimidazol-2-yl)-pyrimidin-2-yl]-amine; [5-(5-tert-Buty)-1H-benzoimidazol-2-yl]-[-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(5-Chloro-4-methyl-1 H-benzoimidazol-2-yl)-4- methyl-pyrimidin-2-yl]-[3-( 1 - methyl-piperidin-4-yl)-propyl]-amine; [5-(5-Fluoro-4-methyl-1H-benzoirnidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3- (1-methyl-pfperidin-4-yl)-propyl]-amine; [5-(6-Fluoro-4-methyl-1H-benzoimidazol-2-2-yl]-[-trifluoromethyl-pyrimidin-2-yl]-[3- (1-methyl-piperidin-4-yl)-propyl]-amine; [5-(4,6-Dichloro-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(5,6-Dlfluoro-1H-benzoimidazol-2-yl]-4-trifluoromethyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4,5-Difluoro-1H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl3-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(1H-Benzoimidazol-2-yl]-pyrazin-2-yl]-[3-(1-methyl-piperidin-4-yl]-propyl]-amine,- [5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-pyrazin-2-yr]-[3-(1-methyl-piperidin-4-yl)- propyl]-amine; [5-(4,6-Bis-trifluoromethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; 2-{4-Methyl-2-[3-(1-methyl-piperidin-4-yI)-propylamino]-pyrimidin-5-yl}-1H- benzoimidazole-5-carbonitrile; [5-(5-Methoxy-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(4-Chloro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3- (1-methyl-piperidin-4-yl)-propyl]-amine; [5-(5-Chloro-6-fluoro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [5-(5-Chloro-1 H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-( 1 -methyl- piperidin-4-yl)-propyl]-amine; [5-(5,6-Dichloro-1 H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-( 1 -methyl- piperidin-4-yl)-propyl]-amine; [5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4-ethyl-pyrimidin-2-yl]-[3-(1-methyl- piperidin-4-yl)-propyl]-amine; [4-Ethyl-5-(4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-piperidin- 4-yl)-propyl]-amine; [4-Cyclopropyl-5-(4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-( 1 -methyl- piperidln-4-yl)-propyl]-amine; [4-CyclopropyI-5-(4,5-dimethyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [4-Cyclopropyl-5-(6-fluoro-4-methyl-1H-b enzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1 - methyl-piperidin-4-yl)-propyl]-amine; [4-Cyclopropyl-5-(4,6-dimethyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl]-propyl]-amine; [4-Cyclopropyl-5-(5-fluoro-4-methyl-1H-benzoirnidazol-2-yl)-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(6-Chloro-5-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; [5-(4-Chloro-6-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1- methyl-piperidin-4-yl)-propyl]-amine; and monohydrates, dihydrates and hemitartrate salts thereof. Benzoimidazol-2-yl pyrimidines, pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritis.

Full Text

BENZOIMIDAZOL-2-YL PYRIMIDINES AND PYRAZINES AS
MODULATORS OF THE HISTAMINE H4 RECEPTOR
Field of the Invention
The present invention relates to certain benzoimidazol-2-yl pyrimidines and
pyrazines, pharmaceutical compositions containing them, and methods of using
them for the treatment of disease states, disorders, and conditions mediated by
histamine H4 receptor activity.
Background of the Invention
The histamine H4 receptor (H4R) is the most recently identified receptor for
histamine (for reviews, see: Fung-Leung, W.-P., et al., Curr. Opin. Invest. Drugs
2004, 5(11), 1174-1183; de Esch, UP., etai., Trends Pharmacol. Sci. 2005,
26(9), 462-469). The receptor is found in the bone marrow and spleen and is
expressed on eosinophils, basophils, mast cells (Liu, C, et al., Mol. Pharmacol.
2001,59(3), 420-426; Morse, K.L., et al., J. Pharmacol. Exp. Ther. 2001, 296(3),
1058-1066; Hofstra, C.L., et al., J.'Pharmacol. Exp. Ther. 2003. 305(3), 1212-
1221; Lippert, U., et al., J. Invest. Dermatol. 2004,123(1), 116-123; Voehringer,
D., et al., Immunity 2004, 20(3), 267-277), CD8+ T cells (Gantner, F., et al., J.
Pharmacol. Exp. Ther. 2002, 303(1), 300-307), dendritic cells, and human
synovial cells from rheumatoid arthritis patients (Ikawa, Y., et al., Biol. Pharm.
Bull. 2005,28(10), 2016-2018). However, expression in neutrophils and
monocytes is less well defined (Ling, P., et al., Br. J. Pharmacol. 2004,142(1),
161-171). Receptor expression is at least in part controlled by various
inflammatory stimuli (Coge, F., et al., Biochem. Biophys. Res. Commun. 2001,
284(2), 301-309; Morse, et al., 2001), thus supporting that H4 receptor activation
influences inflammatory responses. Because of its preferential expression on
immunocompetent cells, the H4 receptor is closely related with the regulatory
functions of histamine during the immune response.
A biological activity of histamine in the context of immunology and
autoimmune diseases is closely related with the allergic response and its
deleterious effects, such as inflammation. Events that elicit the inflammatory
response include physical stimulation (including trauma), chemical stimulation,

infection, and invasion by a foreign body. The inflammatory response is
characterized by pain, increased temperature, redness, swelling, reduced
function, or a combination of these.
Mast cell degranulation (exocytosis) releases histamine and leads to an
inflammatory response that may be initially characterized by a histamine-
modulated wheal and flare reaction. A wide variety of immunological stimuli (e.g.,
allergens or antibodies) and non-immunological (e.g., chemical) stimuli may
cause the activation, recruitment, and de-granulation of mast cells. Mast cell
activation initiates allergic inflammatory responses, which in tμm cause the
recruitment of other effector cells that further contribute to the inflammatory
response. It has been shown that histamine induces chemotaxis of mouse mast
cells (Hofstra, et al., 2003). Chemotaxis does not occur using mast cells derived
from H4 receptor knockout mice. Furthermore, the response is blocked by an H4-
specific antagonist, but not by H1, H2 or H3 receptor antagonists (Hofstra, et al.,
2003; Thurmond, R.L., et al., J. Pharmacol. Exp. Ther. 2004, 309(1), 404-413).
The in vivo migration of mast cells to histamine has also been investigated and
shown to be H4 receptor dependent (Thurmond, et aj., 2004). The migration of
mast cells may play a role in allergic rhinitis and allergy where increases in mast
cell number are found (Kirby, J.G., et al., Am. Rev. Respir. Dis. 1987, 136(2),
379-383; Crimi, E., et al., Am. Rev. Respir. Dis. 1991, 144(6), 1282-1286; Amin,
K., et al., Am. J. Resp. Crit. Care Med. 2000,162(6), 2295-2301; Gauvreau, G.M.,
et al., Am. J. Resp. Crit. Care Med. 2000,161(5), 1473-1478; Kassel, O., et al.,
Clin. Exp. Allergy 2001, 31(9), 1432-1440). In addition, it is known that in
response to allergens there is a redistribution of mast cells to the epithelial lining
of the nasal mucosa (Fokkens, W.J., et al., Clin. Exp. Allergy 1992, 22(7), 701-
710; Slater, A., et al., J. Laryngol. Otol. 1996,110, 929-933). These results show
that the chemotactic response of mast cells is mediated by histamine H4
receptors.
It has been shown that eosinophils can chemotax towards histamine
(O'Reilly, M., et al., J. Recept. Signal Transduction 2002, 22(1-4), 431-448;
Buckland, K.F., et al.. Br. J. Pharmacol. 2003,140(6), 1117-1127; Ling et al.,
2004). Using H4 selective ligands, it has been shown that histamine-induced

chemotaxis of eosinophils is mediated through the H4 receptor (Buckland, et al.,
2003; Ling et al., 2004). Cell surface expression of adhesion molecules
CD11b/CD18 (LFA-1) and CD54 (ICAM-1) on eosinophils increases after
histamine treatment (Ling, et al., 2004). This increase is blocked by H4 receptor
antagonists but not by H1, H2, or H3 receptor antagonists.
The H4R also plays a role in dendritic cells and T cells. In human
monocyte-derived dendritic cells, H4R stimulation suppresses IL-12p70 production
and drives histamine-mediated chemotaxis (Gutzmer, R., et al., J. Immunol. 2005,
174(9), 5224-5232). A role for the H4 receptor in CD8+ T cells has also been
reported. Gantner, et al., (2002) showed that both H4 and H2 receptors control
histamine-induced IL-16 release from human CD8+ T cells. IL-16 is found in the
bronchoalveolar fluid of allergen- or histamine-challenged asthmatics (Mashikian,
V.M., et al., J. Allergy Clin. Immunol. 1998,101 (6, Part 1), 786-792; Krug, N., et
al., Am. J. Resp. Crit Care Med. 2000,162(1), 105-111) and is considered
important in CD4+ cell migration. The activity of the receptor in these cell types
indicates an important role in adaptive immune responses such as those active in
autoimmune diseases.
In vivo H4 receptor antagonists were able to block neutrophillia in zymosan-
induced peritonitis or pleurisy models (Takeshita, K., et al., J. Pharmacol. Exp.
Ther. 2003, 307(3), 1072-1078; Thurmond, et al., 2004). In addition, H4 receptor
antagonists have activity in a widely used and well-characterized model of colitis
(Varga, C, et al., Eur. J. Pharmacol. 2005, 522(1-3), 130-138). These results
support the conclusion that H4 receptor antagonists have the capacity to be anti-
inflammatory in vivo.
Another physiological role of histamine is as a mediator of itch and H1
receptor antagonists are not completely effective in the clinic. Recently, the H4
receptor has also been implicated in histamine-induced scratching in mice (Bell,
J.K., et al., Br. J. Pharmacol. 2004,142(2), 374-380). The effects of histamine
could be blocked by H4 antagonists. These results support the hypothesis that
the H4 receptor is involved in histamine-induced itch and that H4 receptor
antagonists will therefore have positive effects in treating pruritis.

Modulation of H4 receptors controls the release of inflammatory mediators
and inhibits leukocyte recruitment, thus providing the ability to prevent and/or treat
H4-mediated diseases and conditions, including the deleterious effects of allergic
responses such as inflammation. Compounds according to the present invention
have H4 receptor modulating properties. Compounds according to the present
invention have leukocyte recruitment inhibiting properties. Compounds according
to the present invention have anti-inflammatory properties.
Examples of textbooks on the subject of inflammation include: 1) Gallin,
J.I.; Snyderman, R., Inflammation: Basic Principles and Clinical Correlates, 3rd
ed.; Lippincott Williams & Wilkins: Philadelphia, 1999; 2) Stvrtinova, V., et al.,
Inflammation and Fever. Pathophysiology Principles of Diseases (Textbook for
Medical Students); Academic Press: New York, 1995; 3) Cecil; et al. Textbook Of
Medicine, 18th ed.; W.B. Saunders Co., 1988; and 4) Stedman's Medical
Dictionary.
Background and review material on inflammation and conditions related
with inflammation can be found in articles such as the following: Nathan, C,
Nature 2002,420(6917), 846-852; Tracey, K.J., Nature 2002, 420(6917), 853-
859; Coussens, L.M., et al., Nature 2002,420(6917), 860-867; Libby, P., Nature
2002, 420, 868-874; Benoist, C, et al, Nature 2002,420(6917), 875-878;
Weiner, H.L., et al., Nature 2002,420(6917), 879-884; Cohen, J., Nature 2002,
420(6917), 885-891; Steinberg, D., Nature Med. 2002, 8(11), 1211-1217.
Thus, small-molecule histamine H4 receptor modulators according to this
invention control the release of inflammatory mediators and inhibit leukocyte
recruitment, and may be useful in treating inflammation of various etiologies,
including the following conditions and diseases: inflammatory disorders, allergic
disorders, dermatological disorders, autoimmune disease, lymphatic disorders,
pruritis, and immunodeficiency disorders. Diseases, disorders and medical
conditions that are mediated by histamine H4 receptor activity include those
referred to herein.
2-Arylbenzimidazoles have been described as histamine H4 receptor
modulators, see, for example, U.S. Pat. Appl. Publ. 2005/0070550A1. However,

there still remains a need for potent histamine H4 receptor modulators with
desirable pharmaceutical properties.
Summary of the Invention
Certain benzoimidazol-2-yl pyrimidines and pyrazines have now been
found to have histamine H4 receptor-modulating activity.
In one general aspect, the invention relates to compounds of the following
Formula (I):

wherein
each of R1-4 is independently H, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, phenyl, -CF3, -
OCF3, -CN, halo, -NO2, -OC1-4alkyl, -SC1-4alkyl, -S(O)C1-4alkyl, -S02C1-4alkyl,
-C(O)C1-4alkyl, -C(O)phenyl, -C(O)NRaRb, -CO2C1-4alkyl, -CO2H, -C(O)NRaRb,
or-NRaRb;
wherein R8 and Rb are each independently H, C1-4alkyl, or C3-7cycloalkyl;
one of X1 and X2 is N and the other is C-Rc;
where Rc is H, methyl, hydroxymethyl, dimethytaminomethyl, ethyl, propyl,
isopropyl, -CF3, cyclopropyl, or cyclobutyl;
n is 1 or 2;
Z is N, CH, or C(C1-4alkyl);
R6 is H, C1-6alkyl, or monocyclic cycloalkyl;
R8 is H or C1-4alkyl;
R8 and R10 are each independently H or C1-4alkyl; and
R11 is H or C1-4a!kyl.
This invention also relates to any of the following: pharmaceutically
acceptable salts of compounds of Formula (I), pharmaceutically acceptable
prodrugs of compounds of Formula (I), and pharmaceutically active metabolites of
compounds of Formula (I).

In other embodiments, the compound of Formula (i) is a compound
selected from those species described or exemplified in the detailed description
below.
In a further general aspect, the invention relates to pharmaceutical
compositions each comprising: (a) an effective amount of at least one agent
selected from compounds of Formula (I) and pharmaceutically acceptable salts,
pharmaceutically acceptable prodrugs, and pharmaceutically active metabolites
thereof; and (b) a pharmaceutically acceptable excipient.
In another general aspect, the invention is directed to a method of treating
a subject suffering from or diagnosed with a disease, disorder, or medical
condition mediated by histamine H4 receptor activity, comprising administering to
the subject in need of such treatment an effective amount of at least one
compound of Formula (I), or a pharmaceutically acceptable salt, pharmaceutically
acceptable prodrug, or pharmaceutically active metabolite of such compound. In
certain preferred embodiments of the inventive method, the disease, disorder, or
medical condition is inflammation. Inflammation herein refers to the response
that develops as a consequence of histamine release, which in tμm is caused by
at least one stimulus. Examples of such stimuli are immunological stimuli and
non-immunoiogical stimuli.
In another general aspect, the invention is directed to a method for
modulating histamine H4 receptor activity, comprising exposing histamine H4
receptor to an effective amount of at least one of a compound of Formula (I) and
a salt thereof.
Additional embodiments, features, and advantages of the invention will be
apparent from the following detailed description and through practice of the
invention.
Detailed Description of Invention
The invention may be more fully appreciated by reference to the following
description, including the following glossary of terms and the concluding
examples. For the sake of brevity, the disclosures of the publications, including
patents, cited in this specification are herein incorporated by reference.

As used herein, the terms "including", "containing" and "comprising" are
used herein in their open, non-limiting sense.
The term "alkyl" refers to a straight- or branched-chain alkyl group having
from 1 to 12 carbon atoms in the chain. Examples of alkyl groups include methyl
(Me, which also may be structurally depicted by the symbol "I"), ethyl (Et), n-
propyl, isopropyl, butyl, isobutyl, sec-butyl tert-butyl (tBu), pentyl, isopentyl, tert-
pentyl, hexyl, isohexyl, and groups that in light of the ordinary skill in the art and
the teachings provided herein would be considered equivalent to any one of the
foregoing examples.
The term "alkenyl" refers to a straight- or branched-chain alkenyl group
having from 2 to 12 carbon atoms in the chain. (The double bond of the alkenyl
group is formed by two sp2 hybridized carbon atoms.) Illustrative alkenyl groups
include prop-2-enyl, but-2-enyl, but-3-enyl, 2-methylprop-2-enyl, hex-2-enyl, and
groups that in light of the ordinary skill in the art and the teachings provided herein
would be considered equivalent to any one of the foregoing examples.
The term "cycloalkyl" refers to a saturated or partially saturated,
monocyclic, fused polycyclic, or spiro polycyclic carbocycle having from 3 to 12
ring atoms per carbocycle. Illustrative examples of cycloalkyl groups include the
following entities, in the form of properly bonded moieties:

A "heterocycloalkyr refers to a monocyclic, or fused, bridged, or spiro
polycyclic ring structure that is saturated or partially saturated and has from 3 to
12 ring atoms per ring structure selected from carbon atoms and up to three
heteroatoms selected from nitrogen, oxygen, and sulfur. The ring structure may
optionally contain up to two oxo groups on carbon or sulfur ring members.
Illustrative entities, in the form of properly bonded moieties, include:

The term "heteroaryl" refers to a monocyclic, fused tricyclic, or fused
polycyclic aromatic heterocycle (ring structure having ring atoms selected from
carbon atoms and up to four heteroatoms selected from nitrogen, oxygen, and
sulfur) having from 3 to 12 ring atoms per heterocycle. Illustrative examples of
heteroaryl groups include the following entities, in the form of properly bonded
moieties:

Those skilled in the art will recognize that the species of heteroaryl,
cycloalkyl, and heterocycloalkyl groups listed or illustrated above are not
exhaustive, and that additional species within the scope of these defined terms
may also be selected.

The term "halogen" represents chlorine, fluorine, bromine, or iodine. The
term "halo" represents chloro, fluoro, bromo, or iodo.
The term "substituted" means that trie specified group or moiety bears one
or more substituents. The term "unsubstituted" means that the specified group
bears no substituents. The term "optionally substituted" means that the specified
group is unsubstituted or substituted by one or more substituents. Where the
term "substituted" is used to describe a structural system, the substitution is
meant to occur at any valency-allowed position on the system.
Any formula given herein is intended to represent compounds having
structures depicted by the structural formula as well as certain variations or forms.
In particular, compounds of any formula given herein may have asymmetric
centers and therefore exist in different enantiomeric forms. All optical isomers
and stereoisomers of the compounds of the general formula, and mixtures
thereof, are considered within the scope of the formula. Thus, any formula given
herein is intended to represent a racemate, one or more enantiomeric forms, one
or more diastereomeric forms, one or more atropisomeric forms, and mixtures
thereof.
Furthermore, certain structures may exist as geometric isomers (i.e., cis
and trans isomers), as tautomers, or as atropisomers. Additionally, any formula
given herein is intended to represent hydrates, solvates, and polymorphs of such
compounds, and mixtures thereof.
To provide a more concise description, some of the quantitative
expressions given herein are not qualified with the term "about". It is understood
that, whether the term "about" is used explicitly or not, every quantity given herein
is meant to refer to the actual given value, and it is also meant to refer to the
approximation to such given value that would reasonably be inferred based on the
ordinary skill in the art, including equivalents and approximations due to the
experimental and/or measurement conditions for such given value. Whenever a
yield is given as a percentage, such yield refers to a mass of the entity for which
the yield is given with respect to the maximum amount of the same entity that
could be obtained under the particular stoichiometric conditions. Concentrations
that are given as percentages refer to mass ratios, unless indicated differently.

Reference to a chemical entity herein stands for a reference to any one of:
(a) the actually recited form of such chemical entity, and (b) any of the forms of
such chemical entity in the medium in which the compound is being considered
when named. For example, reference herein to a compound such as R-COOH,
encompasses reference to any one of, for example, R-COOH(8), R-COOH(sol), and
R-COO"(sol). In this example, R-COOH(8) refers to the solid compound, as it could
be for example in a tablet or some other solid pharmaceutical composition or
preparation; R-COOH(sol) refers to the undissociated form of the compound in a
solvent; and R-COO"(sol) refers to the dissociated form of the compound in a
solvent, such as the dissociated form of the compound in an aqueous
environment, whether such dissociated form derives from R-COOH, from a salt
thereof, or from any other entity that yields R-COO" upon dissociation in the
medium being considered. In another example, an expression such as "exposing
an entity to compound of formula R-COOH" refers to the exposure of such entity
to the form, or forms, of the compound R-COOH that exists, or exist, in the
medium in which such exposure takes place. In this regard, if such entity is for
example in an aqueous environment, it is understood that the compound R-
COOH is in such same medium, and therefore the entity is being exposed to
species such as R-COOH(aq) and/or R-COO"(aq), where the subscript "(aq)" stands
for "aqueous" according to its conventional meaning in chemistry and
biochemistry. A carboxylic acid functional group has been chosen in these
nomenclature examples; this choice is not intended, however, as a limitation but it
is merely an illustration. It is understood that analogous examples can be
provided in terms of other functional groups, including but not limited to hydroxy!,
basic nitrogen members, such as those in amines, and any other group that
interacts or transforms according to known manners in the medium that contains
the compound. Such interactions and transformations include, but are not limited
to, dissociation, association, tautomerism, solvolysis, including hydrolysis,
solvation, including hydration, protonation, and deprotonation. In another
example, a zwitterionic compound is encompassed herein by referring to a
compound that is known to form a zwitterions, even if it is not explicitly named in
its zwitterionic form. Terms such as zwitterion, zwitterions, and their synonyms

zwitterionic compound(s) are standard IIJPAC-endorsed names that are well
known and part of standard sets of defined scientific names. In this regard, the
name zwitterion is assigned the name identification CHEBI:27369 by the
Chemical Entities of Biological Inerest (ChEBI) dictionary of molecular entities.
(See, for example its on line version at http://www.ebi.ac.uk/chebi/init.do). As
generally well known, a zwitterion or zwitterionic compound is a neutral compound
that has formal unit charges of opposite sign. Sometimes these compounds are
referred to by the term "inner salts". Other sources refer to these compounds as
"dipolar ions", although the latter term is regarded by still other sources as a
misnomer. As a specific example, aminoothanoic acid (the amino acid glycine)
has the formula H2NCH2COOH, and It exists in some media (in this case in
neutral media) in the form of the zwitterion +H3NCH2COO. Zwitterions,
zwitterionic compounds, inner salts and dipolar ions in the known and well
established meanings of these terms are within the scope of this invention, as
would in any case be so appreciated by those of ordinary skill in the art. Because
there is no need to name each and every embodiment that would be recognized
by those of ordinary skill in the art, no structures of the zwitterionic compounds
that are associated with the compounds of this invention are given explicitly
herein. They are, however, part of the embadiments of this invention. No further
examples in this regard are provided herein because these interactions and
transformations in a given medium are known by any one of ordinary skill in the
art.
Any formula given herein is also intended to represent unlabeled forms as
well as isotopically labeled forms of the compounds. Isotopically labeled
compounds have structures depicted by the Formulas given herein except that
one or more atoms are replaced by an atom having a selected atomic mass or
mass number. Examples of isotopes that can be incorporated into compounds of
the invention include isotopes of hydrogen, carbon, nitrogen, oxygen,
phosphorous, fluorine, chlorine, and iodine, s uch as 2H, 3H, 11C, 13C, 14C, 15N, 18O,
17Q 31 p 32P, 35Sj 18F, 36Cl, 125l, respectively. Such isotopically labelled
compounds are useful in metabolic studies (preferably with 14C), reaction kinetic
studies (with, for example 2H or 3H), detection or imaging techniques [such as

positron emission tomography (PET) or single-photon emission computed
tomography (SPECT)] including drug or substrate tissue distribution assays, or in
radioactive treatment of patients. In particular, an 18F or 11C labeled compound
may be particularly preferred for PET or SPECT studies. Further, substitution
with heavier isotopes such as deuterium (i.e., 2H) may afford certain therapeutic
advantages resulting from greater metabolic stability, for example increased in
vivo half-life or reduced dosage requirements. Isotopically labeled compounds of
this invention and prodrugs thereof can generally be prepared by carrying out the
procedures disclosed in the schemes or in the examples and preparations
described below by substituting a readily Eivailable isotopically labeled reagent for
a non-isotopically labeled reagent.
When referring to any formula given herein, the selection of a particular
moiety from a list of possible species for a specified variable is not intended to
define the same choice of the species for the variable appearing elsewhere. In
other words, where a variable appears more than once, the choice of the species
from a specified list is independent of the choice of the species for the same
variable elsewhere in the formula, unless stated otherwise.
By way of a first example on substituent terminology, if substituent S1example
is one of S1 and S2, and substituent S2example is one of S3 and S4, then these
assignments refer to embodiments of this invention given according to the
Choices S example is S1 and S example is S3; S1 example is S1 and S example iS S4; S1 example
is S2 and S2example is S3; S1example is S2 and S2example is S4; and equivalents of each
one of such choices. The shorter terminology "S1example is one of S1 and S2, and
S2 example is one of S3 and S4" is accordingly used herein for the sake of brevity, but
not by way of limitation. The foregoing first example on substituent terminology,
which is stated in generic terms, is meant to illustrate the various substituent
assignments described herein. The foregoing convention given herein for
substituents extends, when applicable, to members such as R1*11, X1, X2, and n,
and any other generic substituent symbol used herein.
Furthermore, when more than one assignment is given for any member or
substituent, embodiments of this invention comprise the various groupings that
can be made from the listed assignments, taken independently, and equivalents

thereof. By way of a second example on substituent terminology, if it is herein
described that substituent Sexample is one of S1, S2, and S3, this listing refers to
embodiments of this invention for which Sexample is S1; Sexample is S2; Sexample is S3;
Sexample is one of S1 and S2; Sexample is one of S1 and S3; Sexample is one of S2 and
S3; Sexample is one of S1, S2 and S3; and Sexample is any equivalent of each one of
these choices. The shorter terminology "Sexample is one of S1, S2, and S3" is
accordingly used herein for the sake of brevity, but not by way of limitation. The
foregoing second example on substituent terminology, which is stated in generic
terms, is meant to illustrate the various substituent assignments described herein.
The foregoing convention given herein for substituents extends, when applicable,
to members such as R1-11, X1, X2, and n, and any other generic substituent
symbol used herein.
The nomenclature "CH" with j > I, when applied herein to a class of
substituents, is meant to refer to embodiments of this invention for which each
and every one of the number of carbon members, from i to j including i and j, is
independently realized. By way of example, the term C1.3 refers independently to
embodiments that have one carbon member (C1), embodiments that have two
carbon members (C2), and embodiments that have three carbon members (C3).
The term Cn-malkyl refers to an aliphatic chain, whether straight or
branched, with a total number N of carbon members in the chain that satisfies n ≤
N ≤ m, with m > n.
Any disubstituent referred to herein is meant to encompass the various
attachment possibilities when more than one of such possibilities are allowed.
For example, reference to disubstituent -A-B-, where A ≠ B, refers herein to such
disubstituent with A attached to a first substituted member and B attached to a
second substituted member, and it also refers to such disubstituent with A
attached to the second substituted member and B attached to the first substituted
member.
According to the foregoing interpretive considerations on assignments and
nomenclature, it is understood that explicit reference herein to a set implies,
where chemically meaningful and unless indicated otherwise, independent

reference to embodiments of such set, and reference to each and every one of
the possible embodiments of subsets of the set referred to explicitly.
In some embodiments of Formula (I), each of R1-4 is independently H,
methyl, tert-butyl, methoxy, -CF3, -CN, fluoro, chloro, methoxycarbonyl, or
benzoyl.
In some embodiments, X2 is N. In other embodiments, X1 is N.
In some embodiments, Rc is H, methyl, ethyl, CF3, cyclopropyl, or
cyclobutyl. In further embodiments, Rc is H or methyl.
In some embodiments, n is 1.
In some embodiments, Z is N or CH. In further embodiments, Z is CH.
In some embodiments, R6 is H, methyl, ethyl, propyl, isopropyl, cyclopropyl,
or cyclobutyl. In further embodiments, R6 is H or methyl.
in some embodiments, R8 is H.
In some embodiments, R9 and R10 are each independently H or methyl. In
further embodiments, R9 and R10 are both H.
In some embodiments, R11 is H or methyl. In further embodiments, R11 is
methyl.
The invention includes also pharmaceutically acceptable salts of the
compounds represented by Formula (I), preferably of those described above and
of the specific compounds exemplified herein.
A "pharmaceutically acceptable salt" is intended to mean a salt of a free
acid or base of a compound represented by Formula (I) that is non-toxic,
biologically tolerable, or otherwise biologically suitable for administration to the
subject. See/generally, S.M. Berge, et al., "Pharmaceutical Salts", J. Pharm.
Sci., 1977, 66:1-19, and Handbook of Pharmaceutical Salts, Properties,
Selection, and Use, Stahl and Wermuth, Eds., Wiley-VCH and VHCA, Zurich,
2002. Examples of pharmaceutically acceptable salts are those that are
pharmacologically effective and suitable for contact with the tissues of patients
without undue toxicity, irritation, or allergic response. A compound of Formula (I)
may possess a sufficiently acidic group, a sufficiently basic group, or both types of

functional groups, and accordingly react with a number of inorganic or organic
bases, and inorganic and organic acids, to form a pharmaceutically acceptable
salt. Examples of pharmaceutically acceptable salts include sulfates,
pyrosulfates, bisulfates, sulfites, bisulfrtes, phosphates, monohydrogen-
phosphates, dihydrogenphosphates, metaphosphates, pyrophosphates,
chlorides, bromides, iodides, acetates, propionates, decanoates, caprylates,
acrylates, formates, isobutyrates, caproates, heptanoates, propiolates, oxalates,
malonates, succinates, suberates, sebacates, fumarates, maleates, butyne-1,4-
dioates, hexyne-1,6-dioates, benzoates, chlorobenzoates, methylbenzoates,
dinitrobenzoates, hydroxybenzoates, methoxybenzoates, phthalates, sulfonates,
xylenesulfonates, phenylacetates, phenylpropionates, phenylbutyrates, citrates,
lactates, v-hydroxybutyrates, glycolates, tartrates, methane-sulfonates,
propanesuffonates, naphthalene-1-sulfonates, naphthalene-2-sulfonates, and
mandelates.
If the compound of Formula (I) contains a basic nitrogen, the desired
pharmaceutically acceptable salt may be prepared by any suitable method
available in the art, for example, treatment of the free base with an inorganic acid,
such as hydrochloric acid, hydrobromic acid, sulfuric acid, sulfamic acid, nitric
acid, boric acid, phosphoric acid, and the like, or with an organic acid, such as
acetic acid, phenylacetic acid, propionic acid, stearic acid, lactic acid, ascorbic
acid, maleic acid, hydroxymaleic acid, isethionic acid, succinic acid, valeric acid,
fumarie acid, malonic acid, pyruvic acid, oxalic acid, glycolic acid, salicylic acid,
oleic acid, palmitic acid, lauric acid, a pyranosidyl acid, such as glucuronic acid or
galacturonic acid, an alpha-hydroxy acid, such as mandelic acid, citric acid, or
tartaric acid, an amino acid, such as aspartic acid or glutamic acid, an aromatic
acid, such as benzoic acid, 2-acetoxybenzoic acid, naphthoic acid, or cinnamic
acid, a sulfonic acid, such as laurylsulfonic acid, p-toluenesulfonic acid,
methanesulfonic acid, ethanesulfonic acid, any compatible mixture of acids such
as those given as examples herein, and any other acid and mixture thereof that
are regarded as equivalents or acceptable substitutes in light of the ordinary level
of skill in this technology.

If the compound of Formula (I) Is an acid, such as a carboxylic acid or
sulfonic acid, the desired pharmaceutically acceptable salt may be prepared by
any suitable method, for example, treatment of the free acid with an inorganic or
organic base, such as an amine (primary, secondary or tertiary), an alkali metal
hydroxide, alkaline earth metal hydroxide, any compatible mixture of bases such
as those given as examples herein, and any other base and mixture thereof that
are regarded as equivalents or acceptable substitutes in light of the ordinary level
of skill in this technology. Illustrative examples of suitable salts include organic
salts derived from amino acids, such as glycine and arginine, ammonia,
carbonates, bicarbonates, primary, secondary, and tertiary amines, and cyclic
amines, such as benzylamines, pyrrolidines, piperidine, morpholine, and
piperazine, and inorganic salts derived from sodium, calcium, potassium,
magnesium, manganese, iron, copper, zinc, aluminum, and lithium.
The invention also relates to treatment methods employing
pharmaceutically acceptable prodrugs of the compounds of Formula (I). The term
"prodrug" means a precursor of a designated compound that, following
administration to a subject, yields the compound in vivo via a chemical or
physiological process such as solvolysis or enzymatic cleavage, or under
physiological conditions (e.g., a prodrug on being brought to physiological pH is
converted to the compound of Formula (I)). A "pharmaceutically acceptable
prodrug" is a prodrug that is not toxic, biologically intolerable, or otherwise
biologically unsuitable for administration to the subject. Illustrative procedures for
the selection and preparation of suitable prodrug derivatives are described, for
example, in "Design of Prodrugs", ed. H. Bundgaard, Elsevier, 1985.
Examples of prodrugs include compounds having an amino acid residue,
or a polypeptide chain of two or more (e.g., two, three or four) amino acid
residues, covalently joined through an amice or ester bond to a free amino,
hydroxy, or carboxylic acid group of a compound of Formula (I). Examples of
amino acid residues include the twenty naturally occurring amino acids,
commonly designated by three letter symbols, as well as 4-hydroxyproline,
hydroxylysine, demosine, isodemosine, 3-methyihistidine, norvalin, beta-alanine,

gamma-aminobutyric acid, citrulline homocysteine, homoserine, ornithine and
methionine sulfone.
Additional types of prodrugs may be produced, for instance, by derivatizing
free carboxyl groups of structures of Formula (I) as amides or alkyl esters.
Examples of amides include those derived from ammonia, primary C1-6alkyl
amines and secondary di(C1-6alkyl) amines. Secondary amines include 5- or 6-
membered heterocycloalkyl or heteroaryl ing moieties. Examples of amides
include those that are derived from ammonia, C1-3alkyl primary amines, and di(Ci.
2alkyl)amines. Examples of esters of the invention include d1-7alkyl, C5-7.
cycloalkyl, phenyl, and phenyl(C1-6alkyl) esters. Preferred esters include methyl
esters. Prodrugs may also be prepared by derivatizing free hydroxy groups using
groups including hemisuccinates, phosphate esters, dimethylaminoacetates, and
phosphoryloxymethyloxycarbonyls, following procedures such as those outlined in
Adv. Drug Delivery Rev. 1996, 19,115. Carbamate derivatives of hydroxy and
amino groups may also yield prodrugs. Carbonate derivatives, sulfonate esters,
and sulfate esters of hydroxy groups may also provide prodrugs. Derivatization of
hydroxy groups as (acyloxy)methyl and (acyloxy)ethyl ethers, wherein the acyl
group may be an alkyl ester, optionally substituted with one or more ether, amine,
or carboxylic acid functionalities, or where the acyl group is an amino acid ester
as described above, is also useful to yield prodrugs. Prodrugs of this type may be
prepared as described in J. Med. Chem. 1996, 39,10. Free amines can also be
derivatized as amides, sulfonamides or phosphonamides. All of these prodrug
moieties may incorporate groups including ether, amine, and carboxylic acid
functionalities.
Pharmaceutically active metabolites may also be used in the methods of
the invention. A "pharmaceutically active metabolite" means a pharmacologically
active product of metabolism in the body of a compound of Formula (I) or salt
thereof. Prodrugs and active metabolites of a compound may be determined
using routine techniques known or available in the art. See, e.g., Bertolini, et al.,
J. Med. Chem. 1997, 40, 2011-2016; Shan, et al., J. Pharm. Scl. 1997, 86 (7),
765-767; Bagshawe, Drug Dev. Res. 1995, 34, 220-230; Bodor, Adv. Drug Res.
1984, 13, 224-331; Bundgaard, Design of F'rodrugs (Elsevier Press, 1985); and

Larsen, Design and Application of Prodrugs, Drug Design and Development
(Krogsgaard-Larsen, et al., eds., Harwood Academic Publishers, 1991).
The compounds of Formula (I) and their pharmaceutically acceptable salts,
pharmaceutically acceptable prodrugs, and pharmaceutically active metabolites
(collectively, "agents") of the present invention are useful as histamine H4
receptor modulators in the methods of the invention. The agents may be used in
the inventive methods for the treatment or prevention of medical conditions,
diseases, or disorders mediated through modulation of the histamine H4 receptor,
such as those described herein. Agents according to the invention may therefore
be used as an anti-inflammatory agents. Symptoms or disease states are
intended to be included within the scope of "medical conditions, disorders, or
diseases."
Accordingly, the invention relates to methods of using the pharmaceutical
agents described herein to treat subjects diagnosed with or suffering from a
disease, disorder, or condition mediated through histamine H4 receptor activity,
such as inflammation.
In a preferred embodiment, an agent: of the present invention is
administered to treat inflammation. Inflammation may be associated with various
diseases, disorders, or conditions, such as inflammatory disorders, allergic
disorders, dermatologica! disorders, autoimmune disease, lymphatic disorders,
and immunodeficiency disorders, including the more specific conditions and
diseases given below. Regarding the onset and evolution of inflammation,
inflammatory diseases or inflammation-mediated diseases or conditions include,
but are not limited to, acute inflammation, allergic inflammation, and chronic
inflammation.
Illustrative types of inflammation treatable with a histamine H4 receptor-
modulating agent according to the invention include inflammation due to or
associated with any one of a plurality of conditions such as allergy, asthma, dry
eye, chronic obstructed pulmonary disease (COPD), atherosclerosis, rheumatoid
arthritis, multiple sclerosis, inflammatory bowel diseases (including colitis, Crohn's
disease, and ulcerative colitis), psoriasis, pruritis, itchy skin, atopic dermatitis,
urticaria (hives), ocular inflammation, conjunctivitis, nasal polyps, allergic rhinitis,

nasal itch, scleroderma, autoimmune thyroid diseases, immune-mediated (also
known as type 1) diabetes mellitus and lupus, which are characterized by
excessive or prolonged inflammation at seme stage of the disease. Other
autoimmune diseases that lead to inflammation include Myasthenia gravis,
autoimmune neuropathies, such as Guillam-Barre, autoimmune uveitis,
autoimmune hemolytic anemia, pernicious anemia, autoimmune
thrombocytopenia, temporal arteritis, anti-phospholipid syndrome, vasculites,
such as Wegener's granulomatosis, Behcet's disease, dermatitis herpetiformis,
pemphigus vulgaris, vitiligio, primary biliary cirrhosis, autoimmune hepatitis,
autoimmune oophoritis and orchitis, autoimmune disease of the adrenal gland,
polymyositis, dermatomyositis, spondyloarthropathies, such as ankylosing
spondylitis, and Sjogren's syndrome.
Pruritis with a histamine H4 receptor-modulating agent according to the
invention includes that which is a symptom of allergic cutaneous diseases (such
as atopic dermatitis and hives) and other metabolic disorders (such as chronic
renal failure, hepatic cholestasis, and diabetes mellitus).
In another preferred embodiment, an agent of the present invention is
administered to treat allergy, asthma, autoimmune diseases, or pruritis.
The term "treat" or "treating" as used herein is intended to refer to
administration of an agent or composition of the invention to a subject for the
purpose of effecting a therapeutic or prophylactic benefit through modulation of
histamine H4 receptor activity. Treating includes reversing, ameliorating,
alleviating, inhibiting the progress of, lessening the severity of, or preventing a
disease, disorder, or condition, or one or more symptoms of such disease,
disorder or condition mediated through modulation of histamine H4 receptor
activity. The term "subject" refers to a mammalian patient in need of such
treatment, such as a human. "Modulators" include both inhibitors and activators,
where "inhibitors" refer to compounds that decrease, prevent, inactivate,
desensitize or down-regulate histamine H4 receptor expression or activity, and
"activators" are compounds that increase, activate, facilitate, sensitize, or up-
regulate histamine H4 receptor expression or activity.

In treatment methods according to the invention, an effective amount of at
least one pharmaceutical agent according to the invention is administered to a
subject suffering from or diagnosed as having such a disease, disorder, or
condition. An "effective amount" means an amount or dose sufficient to generally
bring about the desired therapeutic or prophylactic benefit in patients in need of
such treatment for the designated disease, disorder, or condition. Effective
amounts or doses of the agents of the present invention may be ascertained by
routine methods such as modeling, dose escalation studies or clinical trials, and
by taking into consideration routine factors, e.g., the mode or route of
administration or drug delivery, the pharmacokinetics of the agent, the severity
and course of the disease, disorder, or condition, the subject's previous or
ongoing therapy, the subject's health status and response to drugs, and the
judgment of the treating physician. An example of a dose is in the range of from
about 0.001 to about 200 mg of agent per kg of subject's body weight per day,
preferably about 0.05 to 100 mg/kg/day, or about 1 to 35 mg/kg/day, in single or
divided dosage units (e.g., BID, TID, QID). For a 70-kg human, an illustrative
range for a suitable dosage amount is from about 0.05 to about 7 g/day, or about
0.2 to about 2.5 g/day.
Once improvement of the patient's disease, disorder, or condition has
occurred, the dose may be adjusted for preventative or maintenance treatment.
For example, the dosage or the frequency of administration, or both, may be
reduced as a function of the symptoms, to a level at which the desired therapeutic
or prophylactic effect is maintained. Of course, if symptoms have been alleviated
to an appropriate level, treatment may cease. Patients may, however, require
intermittent treatment on a long-term basis upon any recurrence of symptoms,
In addition, the agents of the invention may be used in combination with
additional active compounds in the treatment of the above conditions. The
additional compounds may be coadministered separately with an agent of
Formula (I) or Included with such an agent as an additional active ingredient in a
pharmaceutical composition according to the invention. In an illustrative
embodiment, additional active compounds are those that are known or discovered
to be effective in the treatment of conditions, disorders, or diseases mediated by

histamine H4 receptor activity, such as another histamine H4 receptor modulator
or a compound active against another target associated with the particular
condition, disorder, or disease. The combination may serve to increase efficacy
(e.g., by including in the combination a compound potentiating the potency or
effectiveness of an agent according to the invention), decrease one or more side
effects, or decrease the required dose of 'the agent according to the invention.
When referring to modulating the target receptor, an "effective amount"
means an amount sufficient to affect the activity of such receptor. Measuring the
activity of the target receptor may be performed by routine analytical methods.
Target receptor modulation is useful in a variety of settings, including assays.
The agents of the invention are used, alone or in combination with one or
more other active ingredients, to formulate pharmaceutical compositions of the
invention. A pharmaceutical composition of the invention comprises an effective
amount of at least one pharmaceutical agent in accordance with the invention. A
pharmaceutically acceptable excipient is part of some embodiments of
pharmaceutical compositions according to this invention.
A "pharmaceutically acceptable excipient" refers to a substance that is not
toxic, biologically intolerable, or otherwise biologically unsuitable for administration
to a subject, such as an inert substance, added to a pharmacological composition
or otherwise used as a vehicle, carrier, or diluent to facilitate administration of a
pharmaceutical agent and that is compatible therewith. Examples of excipients
include calcium carbonate, calcium phosphate, various sugars and types of
starch, cellulose derivatives, gelatin, vegetable oils, and polyethylene glycols.
Delivery forms of the pharmaceutical compositions containing one or more
dosage units of the pharmaceutical agents may be prepared using suitable
pharmaceutical excipients and compounding techniques known or that become
available to those skilled in the art. The compositions may be administered in the
inventive methods by a suitable route of delivery, e.g., oral, parenteral, rectal,
topical, or ocular routes, or by inhalation.
The preparation may be in the form of tablets, capsules, sachets, dragees,
powders, granules, lozenges, powders for reconstitution, liquid preparations, or

suppositories. Preferably, the compositions are formulated for intravenous
infusion, topical administration, or oral administration.
For oral administration, the compounds of the invention can be provided in
the form of tablets or capsules, or as a solution, emulsion, or suspension. To
prepare the oral compositions, the agents may be formulated to yield a dosage of,
e.g., from about 0.05 to about 50 mg/kg daily, or from about 0.05 to about 20
mg/kg daily, or from about 0.1 to about 10 mg/kg daily.
Oral tablets may include the agent and any other active ingredients mixed
with compatible pharmaceutlcally acceptable excipients such as diluents,
disintegrating agents, binding agents, lubricating agents, sweetening agents,
flavoring agents, coloring agents and preservative agents. Suitable inert fillers
include sodium and calcium carbonate, sodium and calcium phosphate, lactose,
starch, sugar, glucose, methyl cellulose, magnesium stearate, mannitol, sorbitol,
and the like. Examples of liquid oral excipients include ethanol, glycerol, water,
and the like. Starch, polyvinyl-pyrrolidone (PVP), sodium starch glycolate,
microcrystalline cellulose, and aiginic acid are examples of disintegrating agents.
Binding agents may include starch and gelatin. The lubricating agent, if present,
may be magnesium stearate, stearic acid or talc. If desired, the tablets may be
coated with a material such as glyceryl monostearate or glyceryl distearate to
delay absorption in the gastrointestinal tract, or may be coated with an enteric
coating.
Capsules for oral administration include hard and soft gelatin capsules. To
prepare hard gelatin capsules, active ingredient may be mixed with a solid, semi-
solid, or liquid diluent. Soft gelatin capsules: may be prepared by mixing the active
ingredient with water, an oil such as peanut oil or olive oil, liquid paraffin, a
mixture of mono and di-glycerides of short chain fatty acids, polyethylene glycol
400, or propylene glycol.
Liquids for oral administration may be in the form of suspensions,
solutions, emulsions or syrups or may be lyophilized or presented as a dry
product for reconstitution with water or other suitable vehicle before use. Such
liquid compositions may optionally contain: pharmaceutically-acceptable
excipients such as suspending agents (for example, sorbitol, methyl cellulose,

sodium alginate, gelatin, hydroxyethylcellulose, carboxymethylcellulose, aluminum
stearate gel and the like); non-aqueous vehicles, e.g., oil (for example, almond oil
or fractionated coconut oil), propylene glycol, ethyl alcohol, or water; preservatives
(for example, methyl or propyl p-hydroxybenzoate or sorbic acid); wetting agents
such as lecithin; and, if desired, flavoring or coloring agents.
The active agents of this invention may also be administered by non-oral
routes. For example, the compositions may be formulated for rectal
administration as a suppository. For parenteral use, including intravenous,
intramuscular, intraperitoneal, or subcutaneous routes, the agents of the invention
may be provided in sterile aqueous solutions or suspensions, buffered to an
appropriate pH and isotonicity or in parentarally acceptable oil. Suitable aqueous
vehicles include Ringer's solution and isotonic sodium chloride. Such forms may
be presented in unit-dose form such as ampules or disposable injection devices,
in multi-dose forms such as vials from which the appropriate dose may be
withdrawn, or in a solid form or pre-concentrate that can be used to prepare an
injectable formulation. Illustrative infusion closes range from about 1 to 1000
ng/kg/minute of agent, admixed with a pharmaceutical carrier over a period
ranging from several minutes to several days.
For topical administration, the agents may be mixed with a pharmaceutical
carrier at a concentration of about 0.1 % to about 10% of drug to vehicle. Another
mode of administering the agents of the invention may utilize a patch formulation
to affect transdermal delivery.
Agents may alternatively be administered in methods of this invention by
inhalation, via the nasal or oral routes, e.g., in a spray formulation also containing
a suitable carrier.
Examples of agents useful in methods of the invention will now be
described by reference to illustrative synthetic schemes for their general
preparation below and the specific examples that follow. Artisans will recognize
that, to obtain the various compounds herein, starting materials may be suitably
selected so that the ultimately desired substituents will be carried through the
reaction scheme with or without protection as appropriate to yield the desired
product. Alternatively, it may be necessary or desirable to employ, in the place of

the ultimately desired substituent, a suitable group that may be carried through
the reaction scheme and replaced as appropriate with the desired substituent.
Unless otherwise specified, the variables are as defined above in reference to
Formula (I).
In the Schemes depicted below, one skilled in the art will recognize that R11
may be replaced with a suitable nitrogen protecting group, such as a tert-
butoxycarbonylgroup (Boc), and that protecting group replaced at a later stage in
the synthesis.

Referring to Scheme A, amines A2 are commercially available or are
prepared from acids A1 or alcohols A3. Coupling of acids A1 with amines R6NH2,
in the presence of activating agents such as dicyclohexyl-carbodiimide,
EDC/HOBt, or carbonyl diimidazole, in a solvent such as DMF or THF, provides
the corresponding amides (not shown). Alternatively, acids A1 are activated to
their corresponding acid chlorides and reacted with amines R6NH2 in the
presence of a suitable base such as triethylamine or diisopropylethylamine, in a
solvent such as DCM or THF. The resulting amides are reduced to amines A2 by
a suitable reducing agent such as LiAIH4, in a solvent such as THF. Alcohols A3
are activated using general methods to form, for example, alkyi halides or alkyl
tosylates. Displacement with R6NH2 in the* presence of a suitable base such as
NaH, NaOH, triethylamine, or diisopropylethylamine, in a solvent such as DCM or
THF, provides amines A2. Alternatively, amines A2 are prepared from alcohols
A3 by reaction with phthalimide or a suitable amino surrogate under Mitsunobu

conditions. Where phthalimide is used, the free amine is revealed through
treatment with hydrazine.

Referring to Scheme B, amines A2 are reacted with pyrimidines B1, which
are commercially available or are prepared by oxidation of commercially available
alkylsulfanyl pyrimidines, or by other general methods, in a solvent such as
pyridine, DMF, MeOH, or EtOH, or a mixture thereof, at temperatures between
about room temperature and the reflux temperature of the solvent, or in a sealed
tube at temperatures up to about 120 °C. 2-Aminopyrimidines B2 are converted
to aldehydes B3 by reduction of the Y substituent with a suitable reducing agent
such as diisobutylaluminum hydride. Where Y is an ester group, reduction
produces aldehydes B3 or the corresponding alcohols (not shown). Where an
alcohol is produced, oxidation using a suitable oxidizing agent such as MnO2,
Dess-Martin periodinane, or Swern conditions, provides aldehydes B3.
Condensation of aldehydes B3 with suitably substituted diamines B4, in the
presence of a dehydrating agent such as NaH2S2O5, in a solvent such as DMF,
MeOH, or EtOH, or a mixture thereof, at temperatures between about room
temperature and the reflux temperature of the solvent, produces compounds of
Formula (I).

Referring to Scheme C, acids A1 or alcohols A3 may be coupled with 2-
aminopyrimidines C1 using the methods described in Scheme A to form amides
and amines C2. Compounds C2 are processed as described in Scheme B to
provide compounds of Formula (I).

Referring to Scheme D, amines A2 are reacted with pyrazines D1, which
are commercially available or are prepared by general methods, in a solvent such
as pyridine, MeOH, or EtOH, or a mixture thereof, at temperatures between about
room temperature and the reflux temperature of the solvent, or in a sealed tube at
temperatures up to about 120 °C. 2-Aminopyrazines D2 are processed into
compounds of Formula (I) as shown in Scheme D using methods analogous to
those described in Scheme B.

Additional synthetic methods are described in U.S. Pat. Appl. Publ.
2005/0070550A1, which is hereby incorporated by reference.
Compounds prepared according to the schemes described above may be
obtained as single enantiomers, diastereomers, or regioisomers, or as racemic
mixtures or mixtures of enantiomers, diastereomers, or regioisomers. Where
regioisomeric or diastereomeric mixtures are obtained, isomers may be separated
using conventional methods such as chromatography or crystallization. Where
racemic (1:1) and non-racemic (not 1:1) mixtures of enantiomers are obtained,
single enantiomers may be isolated using conventional separation methods
known to one skilled in the art. Particularly useful separation methods may
include chiral chromatography, recrystallization, diastereomeric salt formation, or
derivatization into diastereomeric adducts followed by separation.
The following examples are provided to further illustrate aspects of the
invention and various preferred embodiments.
EXAMPLES
Chemistry:
In obtaining the compounds described in the examples below and the
corresponding analytical data, the following experimental and analytical protocols
were followed unless otherwise indicated.
Unless otherwise stated, reaction mixtures were magnetically stirred at
room temperature (rt). Where solutions are "dried," they are generally dried over
a drying agent such as Na2SO4 or MgSO4. Where mixtures, solutions, and
extracts were "concentrated", they were typically concentrated on a rotary
evaporator under reduced pressure.
Thin-layer chromatography was performed using Merck silica gel 60 F264
2.5 cm x 7.5 cm 250 μm or 5.0 cm x 10.0 cm 250 μm pre-coated silica gel plates.
Preparative thin-layer chromatography was performed using EM Science silica gel
60 F254 20 cm x 20 cm 0.5 mm pre-coated plates with a 20 cm x 4 cm
concentrating zone.

Normal-phase flash column chromatography (FCC) was performed on
silica gel (SiO2) eluting with 2 M NH3 in MeOH/DCM, unless otherwise noted.
Reaction mixtures were loaded onto the Si02 column without workup.
Reversed-phase HPLC was performed on a Hewlett Packard HPLC Series
1100, with a Phenomenex Luna C18 (5 μm, 4.6x150 mm) column. Detection was
done at A, = 230,254 and 280 nm. The gradient was 10 to 99% acetonitrile/water
(0.05% trifluoroacetic acid) over 5.0 min with a flow rate of 1 mL/min.
Alternatively, HPLC was performed on a Dionex APS2000 LC/MS with a
Phenomenex Gemini C18 (5 μm, 30 x 100 mm) column, and a gradient of 5 to
100% acetonitrile/water (20 mM NH4OH) over 16.3 min, and a flow rate of 30
mL/min.
Mass spectra (MS) were obtained on an Agilent series 1100 MSO using
electrospray ionization (ESI) in positive mode unless otherwise indicated.
Calculated (calcd.) mass corresponds to the exact mass.
Nuclear magnetic resonance (NMR) spectra were obtained on Bruker
model DRX spectrometers. The format of the 1H NMR data below is: chemical
shift in ppm downfield of the tetramethylsilane reference (multiplicity, coupling
constant J in Hz, integration).
Chemical names were generated using ChemDraw Version 6.0.2
(CambridgeSoft, Cambridge, MA).
Example 1. [5-(5-Fluoro-4-methyl-1H-benzoimidazol-2-yl)4-methyl-pyrimidin-2-
yl]-[3-(1 -methyl-piperidin-4-yl)-propyl]-amine.

Step A: 4-methyl-2-ethylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester. A
mixture of ethyl acetoacetate (6.37 mL, 50.0 mol), dimethylformamide
dimethylacetal (8.94 g, 75.0 mmol), and catalytic p-toluenesulfonic acid was
heated at 100 °C for 2 h. After cooling to it, the mixture was diluted with N.N-
dlmethylformamide (DMF; 50 mL) and 2-ethylisothiourea hydrobromide (9.10 g,
50.0 mmol) was added. After heating the at 100 °C for 18 h, the mixture was

cooled to rt and concentrated to give a crude residue, which was purified by FCC
(EtOAc/hexanes) to give 7.1 g (61%) of a solid. 1H NMR (CDCI3): 8.97-8.91 (m,
1H), 4.43-4.35 (m, 2H), 3.24-3.15 (m, 2H), 2.81-2.72 (m, 3H), 1.47-1.35 (m, 6H).
Step B; 2-Ethanesulfonyl-4-methyl-pyrimidine-5-carboxylic acid ethyl ester.
To a 0 °C solution of 4-methyl-2-ethylsuHanyl-pyrimidine-5-carboxylic acid ethyl
ester (3 g, 13.3 mmol) in dichloromethane (DCM; 50 mL) was added urea
hydrogen peroxide (5.20 g, 55.7 mmol) followed by trifluoroacetic anhydride (7.39
mL, 53.1 mmol) dropwise. The solution was warmed to rt for 2 h before
quenching with satd. aq. Na2S2O3 (20 mL) and extracting with DCM (100 mL).
The organic layer was dried (Na2SO4) and concentrated to give 1.50 g of an
orange solid which was used immediately in the next step without purification. 1H
NMR (CDCI3): 9.28 (s, 1H), 4.47 (q, J = 7.2 Hz, 2H), 3.60 (q, J = 7.5 Hz, 2H), 2.96
(s, 3H), 1.47-1.42 (m,6H).
Step C:4-methyl-2-[3-(1-methyl-piperidin-4-yl)-propylamino]-pyrimidine-5-
carboxylic acid ethyl ester. A mixture of 2-ethanesulfonyl-4-methyl-pyrimidine-5-
carboxylic acid ethyl ester (0.30 g, 1.18 mmol) and 3-(1-methyl-piperidin-4-yl)-
propylamine (0.18 mg, 1.10 mmol) in EtOH (3 mL) was heated in a sealed tube at
100 °C for 6 h. The mixture was concentrated and purified by FCC to give 200
mg (53%). 1H NMR (CDCI3): 8.88-8.72 (m, 1H), 5.60-5.44 (m, 1H), 4.31 (q, J =
7.2 Hz, 2H), 3.52-3.39 (m, 2H), 2.91-2.77 (m, 2H), 2.64 (s, 3H), 2.26 (s, 3H), 1.94-
1.85 (m, 2H), 1.72-1.57 (m, 4H). 1.41-1.20 (m, 8H).
Step D: {4-methyl-2-[3-(1 -methyl-piperidin-4-yl)propylamino]-pyrimidin-5-
yl}-methanol. To a 0 °C solution of 4-methyl-2-[3-(1-methyl-piperidin-4-yl)-
propylamino]-pyrimidine-5-carboxylic acid ethyl ester (0.20 g, 0.63 mmol) in THF
(6 mL) was added diisobutylaluminum hydride (1 M in hexanes; 1.25 mL, 1.25
mmol) dropwise. The mixture was wanned to rt over 1 h. The reaction was
quenched with 1 M H2SO4 (2 mL). The mixture was neutralized with satd. aq.
NaHCO3, and diluted with MeOH (2 mL), CHCI3 (10 mL), and satd. aq. sodium
potassium tartrate (10 mL). The mixture was stirred vigourously until the layers
separated. The organic layer was dried (Na2SO4) and concentrated to give the
crude product (138 mg), which was used in the next step without further
purification. 1H NMR (CDCI3): 8.07 (s, 1H), 4.52 (s, 2H), 3.42-3.33 (m, 2H), 2.88-

2.74 (m, 2H), 2.41 (s, 3H), 2.23 (s, 3H). 1.93-1.83 (m, 2H), 1.72-1.53 (m, 4H),
1.35-1.16 (m,5H).
Step E: [5-(5-Fluoro-4-methyl- 1H-benzoimidazol-2-yl)-pyrimidin.2-yl]-[3-(1-
methyl-piperidin-4-ylpropyl-amine. A mixture of 4-methyl-2-[3-(1-methyl-
piperidin-4-yl)-propylamino]-pyrimidin-5-yl)-methanol (0.14 g. 0.49 mmol) in
toluene (3 mL) was added MnO2 (0.22 g. 2.48 mmol). After 30 min at 70 °C, the
mixture was filtered through diatomaceous earth. The filtrate was concentrated
and immediately dissolved in DMF. A portion of this solution (corresponding to
0.05 mg, 0.17 mmol of 4-methyl-2-[3-(1-methyl-piperidin-4-yl)-propylamino]-
pyrimidine-5-carbaldehyde) was then treated with 4-fluoro-3-methyl-benzene-1,2-
diamine (1.1 equiv.) and Na2H2S2O5 (1.25 equiv.) at 90 °C for 12 h. The reaction
mixture was purified by FCC to afford the title compound. MS: mass calcd. for
C22H29FN6, 396.24; m/z found, 397.2 [M+H]+. 1H NMR (CD3OD): 8.62 (s, 1H),
7.55 (dd, J = 8.0, 3.9 Hz, 1H), 7.17 (dd, J = 10.3, 8.8 Hz, 1H), 3.60 (t, J = 6.9 Hz,
2H), 3.10-2.99 (m, 2H). 2.71 (s, 3H). 2.66 (d, J = 1.4 Hz, 3H), 2.44 (s, 3H), 2.26-
2.17 (m, 2H), 1.98-1.88 (m, 2H), 1.87-1.77 (m, 2H). 1.55-1.36 (m, 5H).
The following compounds in Examples 2-14 were synthesized analogously
to the procedures described in Example 1.
Example 2, [5-(4,6-Dimethyl-1h-benzoimldazol-2yl)-4-methyl-pyrimidin-2-yl]-[3- (1-methyl-piperidin-4-yl)-propyl]-amine

MS: mass calcd. for C23H32N6, 392.27; m/z found, 393.3 [M+H]. 1H NMR
(CD3OD): 8.43 (s, 1H), 7.20 (s, 1H), 6.89 (s, 1H), 3.41 (t, J = 7.0 Hz, 2H), 2.89-
2.82 (m, 2H), 2.54 (s, 3H), 2.53 (s, 3H), 2.42 (3, 3H), 2.25 (s, 3H), 2.05-1.96 (m.
2H), 1.78-1.70 (m, 2H), 1.69-1.59 (m, 2H), 1.34-1.21 (m, 5H).
Example 3, [5-(6-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3- (1-methyl-piperidin-4-yl)-propyl]-amine

MS: mass calcd. for C22H29FN6, 396.24; m/z found, 397.3 [M+H]+. 1H NMR
(CD3OD): 8.45 (s, 1H), 7.10 (dd, J = 8.9, 2.1 Hz, 1H). 6.85 (dd, J = 10.5, 1.5 Hz,
1H), 3.42 (t, J = 7.0 Hz, 2H), 2.90-2.82 (m, 2H), 2.58 (s, 3H), 2.54 (s, 3H), 2.25 (s,
3H), 2.05-1.93 (m, 2H). 1.78-1.71 (m, 2H), 1.69-1.60 (m, 2H), 1.39-1.18 (m, 5H).
Example 4. [5-(4.5-Difluoro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl)-amine.

MS: mass calcd. for C21H26F2N6, 400.22; m/z found. 401.2 [M+H]+. 1H
NMR (CD3OD): 8.49 (s, 1H), 7.32 (ddd, J = 8.8, 3.7,1.1 Hz, 1H), 7.17 (ddd, J =
11.4. 8.8, 7.2 Hz, 1H), 3.43 (t, J = 7.0 H2:, 2H), 2.93-2.82 (m, 2H), 2.58 (s, 3H),
2.27 (s, 3H), 2.08-1.97 (m, 2H), 1.79-1.71 (m, 2H), 1.70-1.60 (m, 2H), 1.40-1.16
(m, 5H).
Example 5. [5-(4.5-Dimethyl-1 H-benzoirnidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-
(1-methyl-piperidin-4-yl)-propyl]-amine.

MS: mass calcd. for C23H32N6, 392.27; m/z found, 393.3 [M+H]+. 1H NMR
(CD3OD): 8.44 (s, 1H), 7.31 (d, J = 7.7 Hz, 1H), 7.07 (d, J = 8.2 Hz, 1H), 3.43 (t, J
= 7.3 Hz, 1H), 2.92-2.82 (m, 2H), 2.53 (s, 3H), 2.51 (s, 3H), 2.39 (s, 3H). 2.26 (s,
3H), 2.07-1.96 (m, 2H), 1.79-1.71 (m, 2H), 1.71-1.61 (m, 2H), 1.41-1.16 (m, 5H).
Example 6. [5-(4.6-Difluoro-1 H-benzoimidazol-2-yl)-4-methyl-Pyrimidin-2-yl]-[3-(1 -
methyl-piperidin-4-yl)-propyl]-amine.

MS: mass calcd. for C21H26F2N6, 400.22; m/z found, 401.2 [M+H]+. 1H
NMR (CD3OD): 8.48 (s, 1H), 7.13 (dd. J = 8.5, 2.1 Hz, 1H), 6.88 (dt, J = 10.4,
10.4, 2.2 Hz, 1H), 3.42 (t, J = 6.9 Hz, 2H), 2.91-2.82 (m, 2H), 2.57 (s, 3H), 2.26 (s,
3H), 2.07-1.97 (m, 2H), 1.80-1.71 (m, 2H), 1.70-1.59 (m, 2H), 1.40-1.17 (m, 5H).
Example 7. [5-(4.6-Dimethyl-1 H-benzoimidazol-2-yl]-4-methyl-pyrimidin-2-yl]-
methyl-[3-(1-methyl-piperidin-4-yl)-propyl]-amine.

MS: mass calcd. for C24H34N6,406 28; m/z found, 407.3 [M+H]+. 1H NMR
(CD3OD): 8.31 (s, 1H), 7.04 (s, 1H), 6.73 (s, 1H), 3.55 (t, J = 7.3 Hz, 2H), 3.04 (s,
3H), 2.75-2.67 (m, 2H). 2.39 (s, 6H). 2.26 (s, 3H). 2.10 (s, 3H), 1.90-1.82 (m, 2H),
1.63-1.47 (m, 4H), 1.17-1.01 (m, 5H).
Example 8. [5-(4.5-Dimethyl-1 H-benzoimidazol-2-yl)-4-ethyl-Pyrimidin-2-yl]-
methyl-[3-(1-methyl-piperidin-4-yl)-propyl]-amine.

MS: mass calcd. for C24H34N6,406.28; m/z found, 407.3 [M+H]+. 1H NMR
(CD3OD): 8.37 (s, 1H), 7.31 (d, J = 8.1 Hz, 1H), 7.06 (d, J = 8.2 Hz, 1H), 3.43 (t, J
= 6.2 Hz, 2H), 2.94-2.81 (m, 4H), 2.50 (s, 3H), 2.39 (s, 3H), 2.25 (s, 3H). 2.05-
1.95 (m,2H), 1.79-1.70 (m,2H), 1.71-1.61 (m, 2H). 1.40-1.10 (m, 8H).
Example 9. [5-(4.5-Difluoro-1 H-benzoimiclazol-2-yl]-4-ethyl-pyrimidin-2-yl]-[3-1-
methyl-piperidin-4-yl)-propyl]-amine.

MS: mass calcd. for C22H28F2N6, 414.23; m/z found, 415.3 [M+H]+. 1H
NMR (CD3OD): 8.42 (s, 1H), 7.32 (ddd, J = 8.8, 3.6, 1.2 Hz, 1H), 7.17 (ddd, J =
11.4, 8.8, 7.2 Hz, 1H), 3.48-3.39 (m, 2H), 3.01-2.91 (m. 2H), 2.90-2.83 (m. 2H),
2.26 (s, 3H), 2.07-1.96 (m, 2H), 1.79-1.60 (m, 4H), 1.38-1.11 (m, 8H).

Example 10. [5-(4-Fluoro-5-methyl-1H-benzoimidazoimidazol-2-yl)-4-propyl-pyrimidin-2-
yl]-[3-(1-methyl-piperidin-4-yl)-propyl]-amine.

MS: mass calcd. for C24H33FN6, 424.28; m/z found. 425.3 [M+H]+. 1H NMR
(CD30D): 8.39 (s, 1H), 7.37 (dd, J = 8.5, 4.2 Hz. 1H), 7.00 (dd. J = 10.3, 8.9 Hz,
1H), 3.43 (t, J = 6.4 Hz, 2H), 2.91-2.82 (m 4H), 2.49 (d, J - 1.4 Hz, 3H), 2.25 (s.
3H), 2.05-1.96 (m, 2H), 1.81-1.57 Example 11. [5-(4.5-Dimethyl-1 H-benzoimidazol-2-yl)-4-isoorooyl-pyrimidin-2-yl]-
[3-(1-methyl-piperidin-4-yl)-propyl]-amine-

MS: mass calcd. for C25H36N6. 420.30; m/z found, 421.3 [M+H]+. 1H NMR
(CD3OD): 8.30 (s, 1H), 7.31 (d, J = 8.1 Hz, 1H), 7.07 (d, J = 8.2 Hz, 1H), 3.47-
3.38 (m, 3H), 2.94-2.73 (m, 2H), 2.50 (s, 3H), 2.39 (s, 3H), 2.25 (s, 3H), 2.05-1.91
(m, 2H), 1.80-1.60 (m, 4H), 1.40-1.21 (m, 5H). 1.19 (d, J = 6.7 Hz, 6H).
Example 12. [5-(4.6-Dimethyl-1 H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-
[3-(1-methyl-piperidin-4-yl)propyl]-amine.

MS: mass calcd. for C25H36N6, 420.30; m/z found. 421.3 [M+H]+. 1H NMR
(CD3OD): 8.29 (s, 1H), 7.19 (s. 1H), 6.90 (s, 1H), 3.50-3.37 (m, 3H), 3.07-2.97 (m,
2H). 2.54 (s, 3H), 2.43 (s, 3H), 2.40 (s, 3H), 2.30-2.20 (m, 2H), 1.85-1.78 (m, 2H),
1.73-1.64 (m, 2H), 1.42-1.26 (m, 5H), 1.19 (d, J - 6.7 Hz, 6H).
Example 13. [4-Cyclobutyl-5-[4.5-dimethyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-
[3-(1-methyl-piperidin-4-yl)-propyl]-amine.

MS: mass calcd. for C26H36N6, 432.30; m/z found, 433.3 [M+H]+. 1H NMR
(CD3OD): 8.31 (s, 1H), 7.31 (d, J = 7.7 H2:, 1H), 7.06 (d, J = 8.2 Hz, 1H), 4.02 (p, J
= 8.4 Hz, 1H), 3.57-3.38 (m, 2H), 2.93-2.81 (m. 2H), 2.50 (s, 3H), 2.39 (s. 3H),
2.38-2.32 (m, 2H), 2.26 (s, 3H), 2.14-1.86 (m, 5H), 1.87-1.61 (m, 5H), 1.43-1.18
(m, 5H).
Example 14. [4-Cyclobutyl-5-(4.5-dlfluoro-1 H-benzoimidazol-2-yl)-pyrimidin-2-yl]-
[3-(1-methyl-piperidln-4-yl)-propyl]-amine.

MS: mass calcd. for C24H30F2N6,440.25; m/z found, 441.3 [M+Hf. 1H
NMR (CD3OD): 8.36 (s, 1H), 7.32 (ddd, J = 8.8, 3.6. 1.1 Hz, 1H), 7.17 (ddd, J =
11.4, 8.8, 7.2 Hz, 1H), 4.10 ( p, J = 8.4 Hz, 1H), 3.57-3.39 (m, 2H), 2.92-2.81 (m,
2H), 2.42-2.29 (m, 2H), 2.27-2.24 (m, 3H), 2.19-2.06 (m, 2H), 2.06-1.94 (m, 2H),
1.90-1.60 (m, 6H), 1.40-1.14 (m, 5H).
Example 15. [5-(5-Fluoro-4-methyl-1 H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1 -
methyl-piperidin-4-yl)-propyl]-amine.

The title compound was prepared from 2-methylsulfanyl-pyrimidine-5-
carboxyllc acid methyl ester (Zhichkin, P. el: al., Synthesis 2002, 6, 720-722) using
methods analogous to those described in Example 1. MS: mass calcd. for
C21H27FN6, 382.23; m/z found, 383.4 [M+H]\ 1H NMR (CD3OD): 9.02-8.85 (m,
2H), 7.45-7.27 (m, 1H), 6.98 (dd, J = 10.1, 8.9 Hz, 1H), 3.43 (t, J - 7.1 Hz, 2H),
2.96-2.88 (m, 2H), 2.51 (s, 3H), 2.30 (s. 3H), 2.14-2.03 (m, 2H), 1.83-1.72 (m,
2H), 1.72-1.61 (m, 2H), 1.41-1.18 (m, 5H).

The compounds in Examples 16-32 were prepared using methods
analogous to those described in Example 1.
Example 16. [4-Cyclobutyl-5-(5-fluoro-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-
2-yl]-[3-(1-methyl-piperidin-4-yl)-propyl]-amine.

MS: mass calcd. for C25H33FN6, 436.28; m/z found, 437.3 [M+H]+.
Example 17. [4-Cyclobutyl-5-(4.6-dimethyl-1 H-benzoimidazol-2-yl)-pyrimidln-2-yl-
[3-(1-methyl-piperidin-4-yl)-propyl]-amine.

MS: mass calcd. for C26H36N6, 432.30; m/z found, 433.3 [M+H]+.
Example 18. [5-(4.5-Dimethyl-1 H-benzoimidazol-2-yl)-4-propyl-pyrimidin-2-yl]-[3-
(1-methyl-piperidin-4-yl)-propyl]-amine.

MS: mass calcd. for C25H38N6, 420.30; m/z found, 421.3 [M+H]+.
Example 19. [4-Ethyl-5-(5-fluoro-4-methyl -1 H-benzoimidazol-2-yl)-pyrimidin-2-yl]-
[3-(1-methyl-piperidin-4-yl)-propyl]-amine.

MS: mass calcd. for C23H31FN6,410.26; m/z found, 411.3 [M+H]+.
Example 20. [5-(5-Fluoro-4-methyl-1 H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-
2-yl]-[3-(1-methyl-piperidin-4-yl-propyl]-amine.

MS: mass calcd. for C24H33FN6,424.28; m/z found. 425.3 [M+Hf.
Example 21. [4-Methyl-5-(4-methyl-1H-benzoimldazol-2-yl)-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine.

MS: mass calcd. for C22H30N6. 378.25; m/z found, 379.3 [M+H]+.
Example 22. [5-(1 H-Benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine.

MS: mass calcd. for C21H28N6, 364.24; m/z found, 365.2 [M+H]+.
Example 23. [5-[5-Fluoro-1 H-benzoimidazol-2-yl)-methyl-pyrimidin-2-yl]-[3-(1 -
methyl-piperldin-4-yl)-propyl]-amine.

MS: mass calcd. for C21H27FN6, 382.23; m/z found, 383.2 [M+H]+.
Example 24. [3-(1-methyl-piperidin-4-yl)propyl]-[4-methyl-5-(5-trifluoromethyl-1H-
benzoimidazol-2-yl)-pyrimidin-2-yl]-amine.

MS: mass calcd. for C22H27N6, 432.22; m/z found, 433.2 [M+H]+.
Example 25. [5-(5-tert-Butyl-1 H-benzolmidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-
(1-methyl-piperidin-4-yl)-propyl]-amine.

MS: mass calcd. for C25H36N6.420.30; m/z found, 421.3 [M+H]+.
Example 26. [5-(5-Chloro-4-methyl-1 H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-
yl]-[3-(1-methyl-piperidin-4-yl)-propyl]-amine.

MS: mass calcd. for C22H29CIN6, 412.21; m/z found, 413.2 [M+H]+.
Example 27. [5-( 5-Fluoro-4-methyl-1 H-benzoimidazol-2-yl)-4-trifluoromethyl-
pyrimidin-2-yl]-[3-(1-methyl-piperidin-4-yl)-propyl]-amine.

MS: mass calcd. for C22H26F4N6,450.22; m/z found, 451.2 [M+H]*.
Example 28. [5-(6-Ftuoro-4-methyl-1 H-berizoimidazol-2-yl)-4-trifluoromethyl-
pyrimidin-2-yl]-[3-(1-methyl-piperidin-4-yl)-propyl]-amine.

MS: mass calcd. for C22H26F4N6, 450.22; m/z found, 451.2 [M+H]+.
Example 29. [5-(4.6-Dichloro-1 H-benzoimidazol-2-yl)4-trifluoromethyl-pyrimidin-
2-yl]-[3-(1-methyl-piperidin-4-yl)-propyl]-amine.

MS: mass calcd. for C21H23CI2F3N6,486.13; m/z found, 487.1 [M+H]+.
Example 30. [5-(4.5-Dimethyl-1 H-benzoimidazol-2-yl)-4-trifluoromethyl-Pyrimidin-
2-yl]-[3-(1-methyl-p|perldin-4-yl)propyl]-amine.

MS: mass calcd. for C23H29F3N6, 446.24; m/z found, 447.3 [M+H]+.
Example 31. [5-(5.6-Difluoro-1H-benzoimldazol-2-yl)4-trifluoromethyl-pyrimidin-
2-yl]-[3-(1-methyl-piperidin-4-yl)-propyl)-amine.

MS: mass calcd. for C21H23F5N6, 454.19; m/z found, 455.2 [M+H]+.
Example 32. [5-(4.5-Diftuoro-1 H-benzoimidazol-2-yl)4-isopropyl-pyrimidin-2-yl]-
[3-(1-methyl-piperidin-4-yl)-propyl]-amine.

MS: mass calcd. for C23H30F2N6, 428.25; m/z found, 429.3 [M+H]+.
Example 33. [5-(5-Fluoro-4-methyl-1 H-benzoimidazol-2-yl)-pyrazin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine.

Step A: 5-[3-(1 -methyl-Piperidin-4-yl)- propylaminol-Pyrazine-2-carboxylic
acid methyl ester. A solution of 5-chloro-pyrazine-2-carboxylic acid methyl ester
(1 equiv.) and 3-(1-methyl-piperidin-4-yl)-propylamine (1.1 equiv.) in MeOH (0.25
M) heated at 100 °C in a sealed tube for 4 h. The mixture was cooled to rt and
concentrated to give a crude product which was purified by FCC.
Step B; 5-[3-(1-Methyl-piperidin-4-yl)-prropylaminol-pyrazine-2-
carbaldehyde. A -78 °C solution of 5-[3-(1-methyl-piperidin-4-yl)-propylamino]-
pyrazine-2-carboxylic acid methyl ester in DCM (0.1 M) was treated with
diisobutylaluminum hydride (1 M in hexanes; 1 equiv.) dropwise. The reaction

was quenched with 1 M H2SO4, neutralized with satd. aq. NaHCO3, and diluted
with MeOH, CHCI3, and satd. aq. sodium potassium tartrate. The mixture was
stirred vigourously until the layers separated. The organic layer was dried
(Na2SO4) and concentrated to give the crude product, which was used in the next
step without further purification.
Step C. The title compound was prepared using methods analogous to
those described in Example 1, Step E, Part 2, to provide the title compound. MS:
mass calcd. for C21H27FN6, 382.23; m/z found, 383.2 [M+H]+.
Example 34. [5-(4.5-Dimethyl-1H-benzoimidazol-2-yl)pyrazin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine.

The title compound was prepared using methods analogous to those
described in Example 33. MS: mass calcd. for C22H30N6, 378.25; m/z found,
379.3 [M+H]+.
The compounds in Examples 35-50 were prepared using methods
analogous to those described in the preceding examples.
Example 35. [5-(4.6-Bis-trifluoromethyl-1H-benzoimidazol-2-yl)-4-methyl-
pyrimidin-2-yl]-[3-(1-methyl-Piperidin-4-yl)-propyl]-amine.

MS (ESI): mass calcd. for C23H26F6N6. 500.49; m/z found, 501.2 [M+H]+.
Example 36. 244-methyl-2-[3-(1-methyl-piperidin-4-yl)-propylamino]-pyrimidin-5-
yl}-1H-benzoimidazole-5-carbonitrile.

MS (ESI): mass calcd. for C22H27N7, 389.51; m/z found, 390.3 [M+H]*. 1H
NMR (MeOD): 8.55 (s, 1H), 7.99 (dd, J = 1.3, 0.5 Hz, 1H), 7.72 (dd, J = 8.3, 0.5
Hz. 1H), 7.57 (dd, J = 8.4, 1.5 Hz, 1H), 3.43 (t, J = 6.8 Hz, 2H), 2.89 (d, J = 12.1
Hz, 2H), 2.62 (s, 3H), 2.28 (s, 3H), 2.05 (t, J = 11.8 Hz, 2H), 1.76 (d, J = 11.3 Hz,
2H), 1.66 (td, J = 14.7, 7.5 Hz, 2H), 1.30 (m. 5H).
Example 37. [5-(5-Methoxy-1 H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1 -
methyl-piperidin-4-yl]-propyl]-amine.
MS (ESI): mass calcd. for C22H30N6O, 394.52; m/z found, 395.3 [M+H]+. 1H
NMR (MeOD): 8.45 (s, 1H), 7.46 (s, J = 8.8 Hz, 1H), 6.90 (dd, J = 8.8, 2.4 Hz,
1H), 7.09 (s, 1H), 3.85 (s, 3H), 3.42 (t, J - 7.1 Hz, 2H), 2.88 (d, J = 11.9 Hz, 2H).
2.56 (s, 3H), 2.27 (s, 3H), 2.03 (t, J = 11.7 Hz, 2H), 1.75 (d, J = 12.7 Hz, 2H), 1.66
(td, J = 15.0, 7.6 Hz, 2H), 1.38-1.20 (m. 5H).
Example 38. [5-(4-Chloro-6-trifluoromethyl-1H-benzolmidazol-2-yl)4-methyl-
pyrimidin-2-yl]-[3-(1-methyl-piperidin-4-yl)-propyl]-amine.
MS (ESI): mass calcd. for C22H26CIF3N6, 466.94; m/z found, 467.2 [M+H]+.
1H NMR (MeOD): 8.55 (s, 1H), 7.83 (s, 1H), 7.55-7.53 (m, 1H), 3.43 (t, J = 6.9 Hz,
2H), 2.88 (d, J = 11.9 Hz, 2H), 2.61 (s, 3H), 2.27 (s, 3H), 2.04 (t, J = 11.8 Hz, 2H),
1.75 (d, J= 12.0 Hz, 2H), 1.66 (m,2H), 1.38-1.18 (m, 5H).
Example 39. [5-[5-Chloro-6-fluoro-1H-benzoirnidazol-2-yl)-4-methyl-pyrimidin-2-
yl]-[3-(1-methyl-piperidin-4-yl)-propyl]-amine.

MS (ESI): mass calcd. for C21H26CIFN6, 416.93; m/z found, 417.2 [M+H]+.
1H NMR (MeOD): 8.49 (s, 1H), 7.67 (d, J = 6.6 Hz, 1H), 7.44 (d, J = 9.3 Hz, 1H), 3.42 (t, J = 7.0 Hz, 2H), 2.87 (d, J = 11.9 Hz, 2H), 2.58 (s, 3H), 2.25 (s, 3H). 2.01
(t, J = 12.7 Hz, 2H), 1.74 (d, J = 12.1 Hz. 2H), 1.65 (dd, J = 14.8, 7.2 Hz, 2H),
1.41-1.16 (m,5H).
Example 40. [5-[5-Chloro-1 H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1 -
methyl-piperidin-4-yl)-propyl]-amine.

MS (ESI): mass calcd. for C21H27CIN6, 398.94; m/z found, 399.2 [M+H]+. 1H
NMR (MeOD): 8.49 (s, 1H), 7.59 (d, J = 1.8 Hz, 1H), 7.55 (d, J = 8.6 Hz, 1H), 7.25
(dd, J - 8.6, 2.0 Hz, 1H), 3.42 (t, J = 6.9 Hz, 2H), 2.87 (d, J = 12.0 Hz, 2H), 2.58
(s, 3H), 2.26 (s, 3H), 2.02 (t, J - 11.7 Hz, 2H), 1.75 (d, J = 12.1 Hz, 2H), 1.65 (td,
J = 14.8, 7.4 Hz, 2H), 1.38-1.19 (m, 5H).
Example 41. [5-(5.6-Dichloro-1H-benzoimidazol-2-yl)-4-methyl-pvrlmidin-2-vl]-[3-
(1 -methyl-piperidin-4-yl)-propyll-amine.

MS (ESI): mass calcd. for C21H26CI2N6.433.39; m/z found, 433.2 [M+H]+.
1H NMR (MeOD): 8.50 (s, 1H), 7.74 (s, 2H), 3.43 (t, J = 7.1 Hz, 2H), 2.93 (d, J =
11.6 Hz, 2H), 2.59 (s, 3H), 2.31 (s, 3H), 2.11 (t, J = 11.3 Hz, 2H), 1.78 (d. J = 12.4
Hz, 2H). 1.66 (m, 2H), 1.33 (m, 6H).
Example 42. [5-(4.6-Dimethyl-1 H-benzoimidazol-2-yl]-4-ethyl-pyrimidin-2-yl]-[3-
(1-methyl-piperidin-4-yl)-propyl]-amine.

MS (ESI): mass calcd. for C24H34N6, 406.58; m/z found, 407.3 [M+H]+. 1H
NMR (MeOD): 8.36 (s, 1H), 7.19 (s, 1H), 6.89 (s, 1H), 3.46-3.39 (m, 2H), 2.88
(dd, J = 15.1, 7.8 Hz, 4H), 2.54 (s, 3H), 2.42 (s, 3H), 2.26 (s, 3H), 2.01 (t, J = 10.9
Hz, 2H), 1.74 (d, J - 11.9 Hz, 2H), 1.66 (dd, J = 14.4, 7.2 Hz. 2H), 1.26 (m, 8H).
Example 43. [4-ethyl-5-(4-methyl-1H-benzoimidazol-2-yl)- pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine.

MS (ESI): mass calcd. for C23H32N6,392.55; m/z found, 393.3 [M+H]+. 1H
NMR (MeOD):.8.39 (s, 1H), 7.41 (d, J = 7.1 Hz, 1H), 7.15 (t, J = 7.7 Hz, 1H), 7.05
(d, J = 7.3 Hz, 1H), 3.44 (t, J = 5.2 Hz, 2H), 2.89 (s, 4H), 2.58 (s, 3H), 2.27 (s,
3H), 2.03 (t, J = 11.7 Hz, 2H), 1.75 (d, J = 12.4 Hz, 2H), 1.67 (td, J = 14.9, 7.3 Hz,
2H), 1.41-1.12 (m,8H).
Example 44. [4-Cyclopropyl-5-(4-methyl-1 H-benzoimidazol-2-yl)-pyrimidin-2-yl]-
[3-(1-methyl-piperidin-4-yl)-propyl]-amine.

MS (ESI): mass calcd. for C24H32N6,404.56; m/z found, 405.3 [M+H]+. 1H
NMR (MeOD): 8.32 (s. 1H), 7.41 (d, J = 6.5 Hz, 1H), 7.17-7.12 (m. 1H), 7.05 (d, J
= 7.3 Hz, 1H), 3.39-3.34 (m, 2H), 2.89 (d, J = 12.0 Hz, 2H), 2.59 (s, 3H), 2.47 (s,
1H), 2.28 (s, 3H), 2.05 (t, J = 11.6 Hz, 2H), 1.75 (d, J = 12.0 Hz, 2H). 1.67-1.58
(m, 2H), 1.38-1,17 (m, 7H), 1.02 (dd, J = 7.3, 3.0 Hz. 2H).
Example 45. r4-Cyclopropyl-5-(4.5-dimethyl-1 H-benzoimidazol-2-yl)-pyrimidin-2-
yl]-[3-(1-methyl-piperidin-4-yl]-propyl]-amine.

MS (ESI): mass calcd. for C25H34N6, 418.59; m/z found, 419.3 [M+H]+. 1H
NMR (MeOD): 8.31 (s, 1H), 7.31 (d, J = 7.2 Hz, 1H), 7.06 (d, J = 8.2 Hz, 1H), 3.36
(t, J = 7.1Hz, 2H), 2.88 (d. J = 12.0 Hz. 2H), 2.56-2.42 (m, 4H), 2.39 (s, 3H), 2.27
(S, 3H), 2.03 (t, J = 11.6 Hz, 2H), 1.74 (d, J = 11.7 Hz, 2H), 1.62 (td, J = 14.7, 7.5
Hz, 2H), 1.38-1.16 (m, 7H), 1.01 (dd, J = 7.5, 3.1 Hz, 2H).
Example 46. [4-Cyclopropyl-5-(6-fluoro-4-methyl-1H-benzoimidazol-2-yl)-
pyrimidin-2-yl]-[3-(1-methyl-piperidin-4-yl)-propyl]-amine.

MS (ESI): mass calcd. for C24H31FN6, 422.55; m/z found, 423.3 [M+H]+. 1H
NMR (MeOD): 8.32 (s, 1H), 7.10 (d, J = 8.0 Hz, 1H), 6.86 (dd, J = 10.5,1.5 Hz,
1H), 3.36 (t, J = 7.3 Hz, 2H), 2.91 (d, J = 12 1 Hz, 2H), 2.59 (s, 3H), 2.48 (s, 1H),
2.29 (s, 3H), 2.07 (t, J = 10.8 Hz, 2H), 1.76 (d, J = 12.3 Hz, 2H), 1.62 (dd. J =
14.3, 7.4 Hz, 2H), 1.40-1.17 (m. 7H), 1.05-0.98 (m, 2H).
Example 47. [4-Cyclopropyl-5-(4.6-dimethyl- 1H-benzoimidazol-2-yl))-pyrimidin-2-
yl1-[3-(1-methyl-piperidin-4-yl)-propyl]-amine

MS (ESI): mass calcd. for C26H34N6, 418.59; m/z found, 419.3 [M+H]+. 1H
NMR (MeOD): 8.30 (s, 1H), 7.20 (s, 1H), 6.89 (s, 1H), 3.36 (t. J = 7.0 Hz, 2H),
2.88 (d, J - 11.5 Hz, 2H). 2.54 (s, 3H), 2.46 (s, 1H), 2.42 (s, 3H), 2.27 (s, 3H),
2.03 (t, J = 11.0 Hz, 2H), 1.74 (d, J = 11.4 Hz, 2H), 1.66-1.57 (m, 2H), 1.38-1.16
(m,7H), 1.04-0.98 (m,2H).

Example 48. [4-Cyclopropyl-5-(5-fluro-4-methyl-1H-benzoimidazol-2-yl)-
pyrimidin-2-yl]-[3-1-methyl-piperidin-4-yl)propyl]-amine.

MS (ESI): mass calcd. for C24H31FN6,422.55; m/z found, 423.3 [M+H]+. 1H
NMR (MeOD): 8.33 (s, 1H), 7.38 (s, 1H), 7.01 (dd, J = 10.3, 8.8 Hz, 1H), 3.37 (t, J
= 7.0 Hz, 1H), 2.91 (d, J = 11.9 Hz, 2H), 2.54-2.43 (m, 4H), 2.30 (s. 3H), 2.08 (t, J
= 10.9 Hz, 2H), 1.94 (s, 1H), 1.76 (d, J = 12.4 Hz, 2H), 1.68-1.59 (m, 2H), 1.42-
1.17 (m, 7H), 1.06-1.00 (m, 2H).
The compounds In Examples 49-50 are prepared using methods
analogous to those described in the preceding examples.
Example 49. [5-(6-Chloro-5-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-
yl]-[3-( 1 -methyl-piperidin-4-yl)-propyl]-amine.

Example 50. [5-(4-Chloro-6-methyl-1 H-benzoimidazol-2-yl]-4-methyl-pyrimidin-2-
yl]-[3(1-methyl-piperidin-4-yl]-propyl]-amine

Additional examples of embodiments of this invention are provided by
hemitartrate salts of compounds of Formula (I) and by hydrates, such as
monohydrates and dehydrates, of compounds of Formula (I). For example,
embodiments of this invention include monohydrates of, dihydrates of, and/or
hemitartrate salts of compounds selected from the group consisting of:

[5-(5-Fluoro-4-methyl-1 H-benzoimidazol -2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1 -
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyI]-amine;
[5-(6-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Difluoro-1H-benzoimidazol-2-yl)-4 methyl-pyrimidin-2-yl]-[3-(1 -methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperid in-4-yl)-propyl]-amine;
[5-(4,6-Difluoro-1H-benzoimIdazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperid in-4-yl)-propyl]-amine;
[5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4methy-pyrimidin-2-yl]-methyl-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-ethyl-pyrimidin-2-yl]-methyl-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Drfluoro-1H-benzoimidazol-2-yl)-4-ethyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4-Fluoro-5-methyl-1H-benzoimidazol-2-yl)-4-propyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Dimethyl-1H-benzofmidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4,6-DimethyI-1H-benzoimidazol-2-yl)-4-isiopropyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[4-Cyclobutyl-5-(4l5-dimethyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[4-Cyclobutyl-6-(4,5-difluoro-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(5-Fluoro-4-methyl-1 H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-( 1 -methyl-
piperidin-4-yl)-propyl]-amine;
[4-Cyclobutyl-5-(5-fluoro-4-methyl-1H-benzoirnidazol-2-yl)-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;

[4-Cyclobutyl-5-(4f6-dimethyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-propyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[4-Ethyl-5-(5-fluoro-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(5-Fluoro-4-methyl-1 H-benzoimidazol-2 -yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1 -
methyl-piperidin-4-yl)-propyl]-amine;
[4-Methyl-5-(4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(1H-Benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-piperidin-4-yl)-
propyl]-amine;
[5-(5-Fluoro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[3-(1-Methyl-piperidin-4-yl)-propyl]-[4-methyl-5-(5-trifluoromethyl-1H-
benzoimidazol-2-yl)-pyrimidin-2-yl]-amine;
[5-(5-tert-Buty)-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(5-Chloro-4-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(5-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-
(1-methyl-piperidin-4-yl)-propyl]-amine;
[5-(6-Fluoro-4-methyl-1H-benzoimidazol-2 -yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-
(1-methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,6-Dichloro-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Dimethyl-1 H-benzoimidazol-2-yl)-4 trifluoromethyl-pyrimidin-2-yl]-[3-(1 -
methyl-piperidin-4-yl)-propyl]-amine;
[5-(5,6-Difluoro-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Difluoro-1 H-benzoimidazol-2-yl)-4- isopropyl-pyrimidin-2-yl]-[3-(1 -methyl-
piperidin-4-yl)-propyl]-amine;

[5-(1H-Benzoimidazol-2-yl)-pyrazin-2-yl]-[3-(1-methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-pyrazin-2-yl]-[3-(1 -methyl-piperidin-4-yl)-
propyl]-amine;
[5-(4,6-Bis-trifluoromethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-( 1 -
methyl-piperidin-4-yl)-propyl]-amine;
2-{4-Methyl-2-[3-(1-methyl-piperidin-4-yl)-propylamino]-pyrimidin-5-yl}-l H-
benzoimidazole-5-carbonitrile;
[5-(5-Methoxy-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4-Chloro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-
(1-methyl-piperidin-4-yl)-propyl]-amine;
[5-(5-Chloro-6-fluoro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(5-Chloro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(5,6-Dichloro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4-ethyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yI)-propyI]-amine;
[4-Ethyl-5-(4-methyl-1 H-benzoimidazol-2-yl )-pyrimidin-2-yl]-[3-(1 -methyl-piperidin-
4-yl)-propyl]-amine;
[4-Cyclopropyl-5-(4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[4-Cyclopropyl-5-(4,5-dimethyl-1H-benzoimidazol-2-yI)-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[4-Cyclopropyl-5-(6-fluoro-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[4-CycIopropyl-5-(4,6-dimethyl-1H-benzoimldazol-2-yl)-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[4-Cyclopropyl-5-(5-fluora-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;

[5-(6-Chloro-5-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine; and
[5-(4-Chloro-6-methyl-1H-benzoimidiazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine.
Biological Testing:
Binding Assay on Recombinant Human Histamine H4 Receptor
SK-N-MC cells or COS7 cells were transiently transfected with pH4R and
grown in 150 cm2 tissue culture dishes. Cells were washed with saline solution,
scraped with a cell scraper and collected by centrifugation (1000 rpm, 5 min).
Cell membranes were prepared by homogenization of the cell pellet in 20 mM
Tris-HCI with a polytron tissue homogenizes for 10 sec at high speed.
Homogenate was centrifuged at 1000 rpm for 5 min at 4 °C. The supernatant
was then collected and centrifuged at 20,000 x g for 25 min at 4 °C. The final
pellet was resuspended in 50 mM Tris-HCI. Cell membranes were incubated with

3H-histamine (5-70 nM) in the presence or absence of excess histamine (10,000
nM). Incubation occurred at room temperature for 45 min. Membranes were
harvested by rapid filtration over Whatman GF/C filters and washed 4 times with
ice-cold 50 mM Tris HCI. Filters were then dried, mixed with scintillant and
counted for radioactivity. SK-N-MC or COS7 cells expressing human histamine
H4 receptor were used to measure the affimity of binding of other compounds and

their ability to displace 3H-ligand binding by incubating the above-described
reaction in the presence of various concern rations of inhibitor or compound to be

tested. For competition binding studies using 3H-histamine, K1 values were
calculated, based on an experimentally determined KD value of 5 nM and a ligand
concentration of 5 nM, according to Y.-C. Cheng and W.H. Prusoff (Biochem.
Pharmacol. 1973, 22(23):3099-3108): K1 = (IC50)/(1 + ([L]/(KD)). Results for the
compounds tested in this assay are presented in Table 1 as an average of results
obtained, and rounded to the nearest 10 nM.

Table 1
While the invention has been illustrated by reference to examples, it is
understood that the invention is intended not to be limited to the foregoing
detailed description.

What is claimed is:
1. A chemical entity that is a compound of Formula (I):

wherein
each of R1-4 is independently H, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, phenyl, -CF3, -
OCF3, -CN, halo, -NO2. -OC1-4alkyl, -SC1-4alkyl, -S(O)C1-4alkyl, -SO2C1-4alkyl,
-C(O)C1-4alkyl, -C(O)phenyl, -C(O)NRaRb, -CO2C1-4alkyl, -CO2H, -C(O)NRaRb,
or-NRaRb;
wherein Ra and Rb are each independently H, C1-4alkyl, or C3-7cycloalkyl;
one of X1 and X2 is N and the other is C-Rc;
where Rc is H, methyl, hydroxymethyl, dimethylaminomethyl, ethyl, propyl,
isopropyl, -CF3, cyclopropyl, or cyclobutyl;
n is 1 or 2;
Z is N, CH, or C(C1-4alkyl);
R6 is H, C1-6alkyl, or monocyclic cycloalkyl;
R8 is H or C1-4alkyl;
R9 and R10 are each independently H or C1-4alkyl; and
R11 is H or C1-4alkyl;
a pharmaceutically acceptable salt of compound of Formula (I), a
pharmaceutically acceptable prodrug of compound of Formula (I), or a
pharmaceutically active metabolite of compound of Formula (I).
2. A chemical entity as defined in claim 1, wherein each of R1-4 is
independently H, methyl, tert-butyl, methoxy, -CF3, -CN, fluoro, chloro,
methoxycarbonyl, or benzoyl.
3. A chemical entity as defined in claim 1, wherein X2 is N.
4. A chemical entity as defined in claim I, wherein X1 is N.

5. A chemical entity as defined in ciiaim 1, wherein Rc is H, methyl, ethyl, CF:
cyclopropyl, or cyclobutyl.
6. A chemical entity as defined in claim 1, wherein Rc is H or methyl.
7. A chemical entity as defined in claim 1, wherein n is 1.
8. A chemical entity as defined in claim 1, wherein Z is N or CH.
9. A chemical entity as defined in claim 1, wherein Z is CH.
10. A chemical entity as defined in claim 1, wherein R6 is H, methyl, ethyl,
propyl, isopropyl, cyclopropyl, or cyclobutyl.

11. A chemical entity as defined in claim 1, wherein R6 is H or methyl.
12. A chemical entity as defined in claim 1, wherein R8 is H.
13. A chemical entity as defined in claim 1, wherein R9 and R10 are each
independently H or methyl.
14. A chemical entity as defined in claim 1, wherein R9 and R10 are both H.
15. A chemical entity as defined in claim 1, wherein R11 is H or methyl.
16. A chemical entity as defined in claim 1, wherein R11 is methyl.
17. A chemical entity selected from:
[5-(5-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidon-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;

[5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(6-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-methyl-Pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Difluoro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4,5-Dimethyl-1H-benzoimldazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4,6-Difluoro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4,6-Dimethyl-1 H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-methyl-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Dimethyl-1 H-benzoimidazol-2-yl)-4- ethyl-pyrimidin-2-yl]-methyl-[3-(1 -
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Difluoro-1H-benzoirnidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4-Fluoro-5-methyl-1H-benzoimidazol-2-yl)-4-propyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4,6-Dimethyl-1 H-benzoimidazol-2-yl)-4- isopropyl-pyrimidin-2-yl]-[3-(1 -methyl-
piperidin-4-yl)-propyl]-amine;
[4-Cyclobutyl-5-(4,5-dimethyl-1H-benzoimiclazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[4-Cyclobutyl-5-(4,5-difluoro-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(5-Fluoro-4-methyl-1H-benzoimldazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[4-Cyclobutyl-5-(5-fluoro-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[4-Cyclobutyl-5-(4,6-dimethyl-1 H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1 -methyl-
piperidin-4-yl)-propyl]-amine;

[5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-propyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl)-amine;
t4-Ethyl-5-(5-fluoro-4-methyl-1H-benzoimiclazol-2-yl)-pyrimidin-2-yl]-(3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(5-Fluoro-4-methyl-1 H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1 -
methyl-piperidin-4-yl)-propyl]-amine;
[4-Methyl-5-(4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl](-amine;
[5-(1 H-Benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-( 1 -methyl-piperidin-4-yl)-
propyl]-amine;
[5-(5-Fluoro-1H-benzoimidazol-2-yl)-4-methyl,-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[3-(1 -Methyl-piperidin-4-yl)-propyl]-[4-methyl-5-(5-trifluoromethyI-1 H-
benzoimidazol-2-yl)-pyrimidin-2-yl]-amine;
[5-(5-tert-Butyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(5-Chloro-4-methyl-1 H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-( 1 -
methyl-piperidin-4-yl)-propyl]-amine;
[5-(5-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-
(1-methyl-piperidin-4-yl)-propyl]-amine;
[5-(6-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-
(1-methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,6-Dichloro-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(5,6-Difluoro-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Difluoro-1H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(1H-Benzoimidazol-2-yl)-pyrazin-2-yl]-[3-(1-methyl-piperidin-4-yl)-propyl]-amine;

[5-(4,5-Dimethyl-1H-benzoimidazol-2-yl;)-pyrazin-2-yl]-[3-(1-methyl-piperidin-4-yl)-
propyl]-amine; and
pharmaceutically acceptable salts thereof.
18. A chemical entity as defined in claim 1, wherein said chemical entity is a
compound of Formula (I) or a pharmaceutically acceptable salt of said compound
of Formula (I).
19. A pharmaceutical composition for treating a disease, disorder, or medical
condition mediated by histamine H4 receptor activity, comprising an effective
amount of at least one agent selected from compounds of Formula (I):

wherein
each of R1-4 is independently H, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, phenyl, -CF3, -
OCF3( -CN, halo, -NO2, -OC1-4alkyl, -SC1-4alkyl, -S(O)C1-4alkyl, -SO2C1-4alkyl,
-C(O)C1-4alkyl, -C(O)phenyl, -C(O)NRaRb, -CO2C1-4alkyl, -CO2H, -C(O)NRaRb,
or-NRaRb;
wherein Ra and Rb are each independently H, C1-4alkyl, or C3-7cycloalkyl;
one of X1 and X2 is N and the other is C-Rc;
where Rc Is H, methyl, hydroxymethyl, dimethylaminomethyl, ethyl, propyl,
isopropyl, -CF3, cyclopropyl, or cyclobutyl;
n is 1 or 2;
Z is N, CH, or C(C1-4alkyl);
R6 is H, C1-6aikyl, or monocyclic cycloalkyl;
R8 is H or C1-4alkyl;
R9 and R10 are each independently H or C1-4alkyl; and
R11 is H or C1-4alkyl;

pharmaceutically acceptable salts of compounds of Formula (I), pharmaceuticaily
acceptable prodrugs of compounds of Formula (I), and pharmaceuticaily active
metabolites of compounds of Formula (I].
20. A pharmaceutical composition according to claim 19, wherein said at least
one agent is selected from:
[5-(5-Fluoro-4-methyt-1H-benzoimidazol-2-yl)-4-methy-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(6-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Difluoro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4,6-Difluoro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-methyl-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Dimethyl-1 H-benzoimidazol-2-yl)-4-ethyl-pyrimidin-2-yl]-methyl-[3-(1 -
methyl-piperldin-4-yl)-propyl]-amine;
[5-(4,5-Difluoro-1H-benzoimidazol-2-yl)-4-ethyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4-Fluoro-5-methyl-1H-benzoimidazol-2-yl)-4-propyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Dlmethyl-1 H-benzoimidazol-2-yl)-4-lsopropyl-pyrimidin-2-yl]-[3-( 1 -methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[4-Cyclobutyl-5-(4,5-dimethyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-( 1 -methyl-
piperidin-4-yl)-propyl]-amine;

[4-Cyclobutyl-5-(4,5-difluoro-1H-benzoimida2ol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(5:Fluoro-4-methyl-1 H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-( 1 -methyl-
piperidin-4-yl)-propyl]-amine;
[4-Cyclobutyl-5-(5-fluoro-4-methyl-1H-berizoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[4-Cyclobutyl-5-(4,6-dimethyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
piperid in-4-yl)-propyl]-amine;
[5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-propyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[4-Ethyl-5-(5-fluoro-4-methyl-1H-benzoirnidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(5-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[4-Methyl-5-(4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(1H-Benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-piperidin-4-yl)-
propyl]-amine;
[5-(5-Fluoro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[3-(1-Methyl-piperldin-4-yl)-propyl]-[4-methyl-5-(5-trifluoromethyl-1H-
benzoimidazol-2-yl)-pyrimidin-2-yl]-amine;
[5-(6-tert-Butyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(5-Chloro-4-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(5-Fluoro-4--methyl-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-
(1-methyl-piperidin-4-yl)-propyl]-amine;
[5-(6-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-
(1-methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,6-Dichloro-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;

[5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4"trifluoromethyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(5,6-Difluoro-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Difluoro-1H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(1 H-Benzoimidazol-2-yl)-pyrazin-2-yl]-[3 -(1 -methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-pyrazin-2-yl]-[3-(1-methyl-piperidin-4-yl)-
propyl]-amine; and
pharmaceutically acceptable salts thereof.
21. A method of treating a subject suffering from or diagnosed with a disease,
disorder, or medical condition mediated by histamine H4 receptor activity,
comprising administering to a subject in need of such treatment an effective
amount of at least one agent selected from compounds of Formula (I):
wherein
each of R1-4 is independently H, C1-4alky I, C2-4alkenyl, C2-4alkynyl, phenyl, -CF3. -
OCF3, -CN, halo, -NO2, -OC1-4alkyl, -SC1-4alkyl, -S(O)C1-4alkyl, -SO2C1-4alkyl,
-C(O)C1-4alkyl, -C(O)phenyl, -C(O)NRaRb, -CO2C1-4alkyl. -CO2H, -C(O)NRaRb,
or-NRaRb;
wherein Ra and Rb are each independently H, C1-4alkyl, or C3-7cycloalkyl;
one of X1 and X2 is N and the other is C-Rc;
where Rc is H, methyl, hydroxymethyl, dimethylaminomethyl, ethyl, propyl,
isopropyl, -CF3, cyclopropyl, or cyclobutyl;
n is 1 or 2;
Z is N, CH, or C(C1-4alkyl);
R6 is H, C1-6alkyl, or monocyclic cycloalkyl;
R8 is H or C1-4alkyl;

R9 and R10 are each independently H or C1-4alkyl; and
R11 is H or C1-4alkyl;
pharmaceutically acceptable salts of compounds of Formula (I), pharmaceutically
acceptable prodrugs of compounds of Formula (I), and pharmaceutically active
metabolites of compounds of Formula (I).
22. A method according to claim 21, wherein said at least one agent is
selected from:
[5-(5-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,6-Dimethyl-1H-benzolmidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(6-Fluoro-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Difluoro-1H-benzoimidazol-2-yl)-4-methy|-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4,5-Dimemyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4,6-Difluoro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-methyl-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Dimethyl-1 H-benzoimidazol-2-yl)-4-ethyl-pyrimidin-2-yl]-methyl-[3-( 1 -
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Difluoro-1 H-benzoimidazol-2-yl)-4-ethyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyrl]-amine;
[5-(4-Fluoro-5-methyl-1H-benzoimidazol-2-yl)-4-propyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;

[4-Cyclobutyl-5-(4,5-dimethyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[4-Cyclobuty1-5-(4,5-difluoro-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(5-Fluoro-4-methyl-1H-benzoimidazol-;2-yl)-pyrimidin-2-y)]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[4-Cyclobutyl-5-(5-fluoro-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[4-Cyclobutyl-5-(4,6-dimethyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-propyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[4-Ethyl-5-(5-fluoro-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
p)peridin-4-yl)-propyl]-amine;
[5-(5-Fluoro-4-methyl-1H-benzoimidazoI-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[4-Methyl-5-(4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(1H-Benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-piperidin-4-yl)-
propyl]-amine;
[5-(5-Fluoro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[3-(1-Methyl-piperidin-4-yl)-propyl]-[4-methyl-5-(5-trifluoromethyl-1H-
benzoimidazol-2-yl)-pyrimidin-2-yl]-amine;
[5-(5-tert-Butyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(5-Chloro-4-methyl-1 H-benzoimidazol-2- yl)-4-methyl-pyrimldin-2-yl]-[3-( 1 -
methyl-piperidin-4-yl)-propyl]-amine;
[5-(5-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-
(1 -methyl-piperidin-4-yl)-propyl]-amine;
[5-(6-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-trifluoromethyl-pyrimidin-2-yl-[3-
(1 -methyl-piperidin-4-yl)-propyl]-amine;

[5-(4,6-Dichloro-1H-benzoimida20l-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(5,6-Difluoro-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-(1-
methy|-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Difluoro-1H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(1H-Benzoimidazol-2-yI)-pyrazin-2-yl]-[3-(1-methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-pyrazin-2-yl]-[3-(1-methyl-piperidin-4-yl)-
propyl]-amine; and
pharmaceutically acceptable salts thereof
23. A method according to claim 21, wherein the disease, disorder, or medical
condition is inflammation.
24. A method according to claim 21, wherein the disease, disorder, or medical
condition is selected from the group consisting of: Inflammatory disorders,
allergic disorders, dermatological disorders, autoimmune disease, lymphatic
disorders, and immunodeficiency disorders
25. A method according to claim 21, wherein the disease, disorder, or medical
condition is selected from: allergy, asthma, dry eye, chronic obstructed
pulmonary disease (COPD), atherosclerosis, rheumatoid arthritis, multiple
sclerosis, inflammatory bowel diseases, colitis, Crohn's disease, ulcerative colitis,
psoriasis, pruritis, itchy skin, atopic dermatitis, urticaria, hives, ocular
inflammation, conjunctivitis, nasal polyps, allergic rhinitis, nasal itch, scleroderma,
autoimmune thyroid diseases, immune-mediated diabetes mellitus, lupus,
Myasthenia gravis, autoimmune neuropathies, Guillain-Barr6, autoimmune uveitis,
autoimmune hemolytic anemia, pernicious anemia, autoimmune
thrombocytopenia, temporal arteritis, anti-phosphollpid syndrome, vasculltides,
Wegener's granulomatosis, Behcet's disease, dermatitis herpetiformis,

pemphigus vulgaris, vitiligio, primary biliary cirrhosis, autoimmune hepatitis,
autoimmune oophoritis, autoimmune orchitis, autoimmune disease of the adrenal
gland, polymyositis, dermatomyositis, spondyloarthropathies, ankylosing
spondylitis, and Sjogren's syndrome.
26. A method according to claim 21, wherein the disease, disorder, or medical
condition is selected from: allergy, asthma, autoimmune diseases, and pruritis.
27. A method for modulating histamine H4 receptor activity, comprising
exposing histamine H4 receptor to an effective amount of at least one agent
selected from a compound of Formula (I):
wherein
each of R1-4 is independently H, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, phenyl, -CF3, -
OCF3, -CN. halo. -NO2, -OC1-4alkyl, -SC1-4alkyl, -S(O)C1-4alkyl, -SO2C1-4alkyl,
-C(O)C1-4alkyl, -C(O)phenyl, -C(O)NRaRb, -CO2C1-4alkyl, -CO2H, -C(O)NRaRb,
or -NRaRb;
wherein Ra and Rb are each independently H, C1-4alkyl, or C3-7cycloalkyl;
one of X1 and X2 is N and the other is C-Rc;
where Rc is H, methyl, hydroxymethyl, climethylaminomethyl, ethyl, propyl,
isopropyl, -CF3, cyclopropyl, or cyclobutyl;
n is 1 or 2;
Z is N, CH, or C(C1-4alkyl);
R6 is H, C1-6alkyl, or monocyclic cycloalkyl;
R8 is H or C1-4alkyl;
R9 and R10 are each independently H or C1-4alkyl; and
R11 is H or C1-4alkyl;
and a salt of a compound of Formula (I).

28. A method according to claim 27, wherein said at least one agent is one of.
I5-(6-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-methyl,-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,6-Dimethyl-1H-benzoimida2ol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyll-amine;
[5-(6-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-
methyi-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Difluoro-1 H-benzoimidazol-2-yl)-4- methyl-pyrimidin-2-yl]-[3-( 1 -methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4,5-Dimethyi-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4,6-Difluoro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4,6-Dimethyl-1 H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-methyl-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-ethyl-pyrimidin-2-yl]-methyl-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Difluoro-1H-benzoimidazol-2-yl)-4-ethyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4-Fluoro-5-methyl-1H-benzoimidazol-2-yl)-4-propyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Dimethyl-1 H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-( 1 -methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[4-Cyclobutyl-5-(4,5-dimethyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[4-Cyclobutyl-5-(4,5-difluoro-1 H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-( 1 -methyl-
piperidin-4-yl)-propyl]-amine;
[5-(5-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;

[4-Cyclobutyl-5-(5-fluoro-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[4-Cyclobutyl-5-(4,6-dimethyl-1 H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-( 1 -methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-propyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[4-Ethyl-5-(5-fluoro-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(5-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[4-Methyl-5-(4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(1H-Benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-piperidin-4-yl)-
propyl]-amine;
[5-(5-Fluoro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[3-(1-Methyl-piperidin-4-yl)-propyl]-[4-methyl-5-(5-trjfluoromethyl-1H-
benzoimidazol-2-yl)-pyrimidin-2-yl]-amine
[5-(5-tert-Butyl-1H-benzoimidazol-2-yI)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
l5-(5-Chloro-4-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(5-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-
(1-methyl-piperidin-4-yl)-propyl]-amine;
[5-(6-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-
(1-methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,6-Dichloro-1 H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-( 1 -
methyl-piperidin-4-yl)-propyl)-amine;
[5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(5,6-Difluoro-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl)-amine;

[5-(4,5-Difluoro-1 H-benzoimidazol-2yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(1H-Benzoimidazol-2-yl)-pyrazin-2-yl]-[3-(1-methyl-piperidin-4-yl)-propyll-amine;
[5-(4,5-Dimethyl-1 H-benzoimidazol-2 -yl)-pyrazin-2-yl]-[3-( 1 -methyl-piperidin-4-yl)-
propyl]-amine; and
salts thereof.
29. A chemical entity selected from:
[5-(4,6-Bis-trifluoromethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
2-{4-Methyl-2-[3-( 1 -methyl-piperidin-4-yl)-propylamino]-pyrimidin-5-yl}-1 H-
benzoimidazole-5-carbonitrile;
[5-(5-Methoxy-1H-benzolmidazol-2-yl]-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl)-amine;
[5-(4-Chloro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-
(1-methyl-piperidin-4-yl)-propyl]-amine;
[5-(5-Chloro-6-fluoro-1H-benzoimidazol-2-yl]-[-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-{6-Chloro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(5,6-Dichloro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4,6-Dimethyl-1 H-benzolmidazol-2-yl)-4-ethyl-pyrimidin-2-yl]-[3-(1 -methyl-
piperidin-4-yl)-propyl]-amrne;
[4-Ethyl-5-(4-methyl-1H-benzoimldazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-piperidin-
4-yl)-propyl]-amine;
[4-Cyclopropyl-5-(4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[4-Cyclopropyl-5-(4,5-dimethyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[4-Cyclopropyl-5-(6-fluoro-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;

[4-Cyclopropyl-5-(4,6-dimethyl-1H-ben2oirniclazol-2-yl)-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[4-Cyclopropyl-5-(5-fluoro-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(6-Chloro-5-methyl-1 H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-( 1 -
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4-Chloro-6-methyl-1H-benzoimidazol-2-yl]-[-methyl-pyrimidin-2-yl]-[3-{1-
methyl-piperidin-4-yl)-propyl]-amine;
and pharmaceutically acceptable salts thereof.
30. A pharmaceutical composition according to claim 19, wherein said at least
one agent is selected from:
[5-(4,6-Bis-trifluoromethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
2-{4-Methyl-2-[3-(1-methyl-piperidin-4-yl)-propylamino]-pyrimidin-5-yl}-1H-
benzoimidazole-5-carbonitrile;
[5-(5-Methoxy-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperldin-4-yl)-propyl]-amine;
[5-(4-Chloro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-
(1-methyl-piperidin-4-yl)-propyl]-amine;
[5-(5-Chloro-6-fluoro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(5-Chloro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(5,6-Dichloro-1H-benzoimidazol-2-yl]-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4-ethyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[4-Ethyl-5-(4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-piperidin-
4-yl)-propyl]-amine;
[4-Cyclopropyl-5-(4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;

[4-Cyclopropyl-5-(4,5-dimethy|-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[4-Cyclopropyl-5-(6-fluoro-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[4-Cyclopropyl-5-(4,6-dimethyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-
nriethyl-piperidin-4-yl)-propyl]-amine;
[4-Cyclopropyl-5-(5-fluoro-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(6-Chloro-5-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yI)-propyl]-amine;
[5-(4-Chloro-6-methyl-1H-benzoimidazol-2-yl]-[-methyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
and pharmaceutically acceptable salts thereof.
31. A method according to claim 21, wherein said at least one agent is
selected from:
[5-(4,6-Bis-trifluoromethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
2-{4-Methyl-2-[3-(1-methyl-piperidin-4-yl)-propylamino]-pyrimidin-5-yl}-1H-
benzoimldazole-5-carbonitrile;
[5-(5-Methoxy-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4-chloro-6-trifluoromethyl-1H-benzoimiclazol-2-yl]-[-methyl-pyrimidin-2-yl]-[3-
(1-methyl-piperidin-4-yl)-propyl]-amine;
[5-(5-Chloro-6-fluoro-1H-benzoimldazol-2-yl]-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(5-Chloro-1 H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-( 1 -methyl-
piperidin-4-yl)-propyl]-amine;
[5-(5,6-Dichloro-1H-benzoimidazol-2-yl]-[-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4-ethyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;

[4-Ethyl-5-(4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-piperidin-
4-yl)-propyl]-amine;
t4-Cyclopropyl-5-(4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[4-Cyclopropyl-5-(4,5-dimethyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[4-Cyclopropyl-5-(6-fluoro-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[4-Cyclopropyl-5-(4,6-dimethyl-1 H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-( 1 -
methyl-piperidin-4-yl)-propyl]-amine;
[4-Cyclopropyl-5-(5-fluoro-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(6-Chloro-5-methyl-1 H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1 -
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4-Chloro-6-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-
methyt-piperidin-4-yl)-propyl]-amine;
and pharmaceutically acceptable salts thereof.
32. A chemical entity that is a compound of Formula (I):

wherein
each of R1-4 is independently H, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, phenyl, -CF3, -
OCF3, -CN, halo, -NO2, -OC1-4alkyl, -SC1-4alkyl, -S(O)C1-4alkyl, -SO2C1-4alkyl.
-C(O)C1-4alkyl, -C(O)phenyl, -C(O)NRaRb, -CO2C1-4alkyl, -CO2H, -C(O)NRaRb.
or -NRaRb;
wherein Ra and Rb are each independently H, C1-4alkyl, or C3-7cycloalkyl;
one of X1 and X2 is N and the other is C-Rc;
where Rc is H, methyl, hydroxymethyl, dimethylaminomethyl, ethyl, propyl,
isopropyl, -CF3, cyclopropyl, or cyclobutyl;

n is 1 or 2;
Z is N, CH, or C(C1-4alkyl);
R6 is H, C1-6alky), or monocyclic cycloalkyl;
R8 is H or C1-4alkyl;
R9 and R10 are each independently H or C1-4alkyl; and
R11 is H or C1-4alkyl;
a monohydrate of a compound of Formula (I), a dihydrate of a compound of
Formula (I), or a hemltartrate salt of a compound of Formula (I).
33. A chemical entity selected from:
[5-(5-Fluoro-4-methyl-1H-benzoimidazol-2:-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(6-Fluoro-4-methyl-1 H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Difluoro-1H-benzoimidazol-2-yl)-4-methyl-pyrlmidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyr]-amine;
[5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4t6-Difluoro-1 H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-( 1-methyl-
piperidin-4-yl )-propyl]-amine;
[5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-methyl-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Dimethyl-1H-benzoimidazol-2-yl]-4-ethyl-pyrimidin-2-yl]-methyl-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Difluoro-1H-benzoimidazol-2-yl)-4-ethyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4-Fluoro-5-methyl-1H-benzoimidazol-2-yl)-4-propyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-y|)-propyl]-amine;

[5-(4,6-Dimethyl-1H-benzoimidazol-2-yl]-[-isopropyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[4-Cyclobutyl-5-(4,5-dimethyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[4-Cyclobutyl-5-(4,5-difluoro-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yI)-propyl]-amine;
[5-(5-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[4-Cyclobutyl-5-(5-fluoro-4-methyl-1H-benzoimidazoI-2-yl)-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[4-Cyclobutyl-5-(4,6-dimethyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methy)-
piperidin-4-yI)-propyl]-amine;
[5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-propyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[4-Ethyl-5-(5-fluoro-4-methyl-1H-benzoimdazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(5-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl]-propyl]-amine;
[4-Methyl-5-(4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(1H-Benzojmidazof-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-piperidin-4-yl)-
propyl]-amine;
[5-(5-Fluoro-1H-benzoimidazol-2-yI)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[3-(1-Methyl-piperidin-4-yl)-propyl]-[4-methy)-5-(5-trifluoromethyl-1H-
benzoimidazol-2-yl)-pyrimidin-2-yl]-amine;
[5-(5-tert-Buty)-1H-benzoimidazol-2-yl]-[-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(5-Chloro-4-methyl-1 H-benzoimidazol-2-yl)-4- methyl-pyrimidin-2-yl]-[3-( 1 -
methyl-piperidin-4-yl)-propyl]-amine;
[5-(5-Fluoro-4-methyl-1H-benzoirnidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-
(1-methyl-pfperidin-4-yl)-propyl]-amine;

[5-(6-Fluoro-4-methyl-1H-benzoimidazol-2-2-yl]-[-trifluoromethyl-pyrimidin-2-yl]-[3-
(1-methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,6-Dichloro-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-trifluoromethyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(5,6-Dlfluoro-1H-benzoimidazol-2-yl]-4-trifluoromethyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4,5-Difluoro-1H-benzoimidazol-2-yl)-4-isopropyl-pyrimidin-2-yl3-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(1H-Benzoimidazol-2-yl]-pyrazin-2-yl]-[3-(1-methyl-piperidin-4-yl]-propyl]-amine,-
[5-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-pyrazin-2-yr]-[3-(1-methyl-piperidin-4-yl)-
propyl]-amine;
[5-(4,6-Bis-trifluoromethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
2-{4-Methyl-2-[3-(1-methyl-piperidin-4-yI)-propylamino]-pyrimidin-5-yl}-1H-
benzoimidazole-5-carbonitrile;
[5-(5-Methoxy-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4-Chloro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-
(1-methyl-piperidin-4-yl)-propyl]-amine;
[5-(5-Chloro-6-fluoro-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[5-(5-Chloro-1 H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-( 1 -methyl-
piperidin-4-yl)-propyl]-amine;
[5-(5,6-Dichloro-1 H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-( 1 -methyl-
piperidin-4-yl)-propyl]-amine;
[5-(4,6-Dimethyl-1H-benzoimidazol-2-yl)-4-ethyl-pyrimidin-2-yl]-[3-(1-methyl-
piperidin-4-yl)-propyl]-amine;
[4-Ethyl-5-(4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-methyl-piperidin-
4-yl)-propyl]-amine;

[4-Cyclopropyl-5-(4-methyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-( 1 -methyl-
piperidln-4-yl)-propyl]-amine;
[4-CyclopropyI-5-(4,5-dimethyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[4-Cyclopropyl-5-(6-fluoro-4-methyl-1H-b enzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1 -
methyl-piperidin-4-yl)-propyl]-amine;
[4-Cyclopropyl-5-(4,6-dimethyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl]-propyl]-amine;
[4-Cyclopropyl-5-(5-fluoro-4-methyl-1H-benzoirnidazol-2-yl)-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(6-Chloro-5-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
[5-(4-Chloro-6-methyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-
methyl-piperidin-4-yl)-propyl]-amine;
and monohydrates, dihydrates and hemitartrate salts thereof.

Benzoimidazol-2-yl pyrimidines, pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, including allergy, asthma, autoimmune diseases, and
pruritis.

Documents:

http://ipindiaonline.gov.in/patentsearch/GrantedSearch/viewdoc.aspx?id=N9wTwlhHTEJJmQRDYGuzAQ==&loc=wDBSZCsAt7zoiVrqcFJsRw==

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Patent Number

270177

Indian Patent Application Number

4373/KOLNP/2008

PG Journal Number

49/2015

Publication Date

04-Dec-2015

Grant Date

30-Nov-2015

Date of Filing

30-Oct-2008

Name of Patentee

JANSSEN PHARMACEUTICA, N.V.

Applicant Address

TURNHOUTSEWEG 30, B-2340 BEERSE

Inventors:

#	Inventor's Name	Inventor's Address
1	DAVID E. KINDRACHUK	1317 EVERGREEN DRIVE, CARDIFF BY THE SEA, CALIFORNIA 92007
2	CHRISTOPHER M. MAPES	8255 PASADENA AVENUE, LA MESA CALIFORNIA 91941
3	JAMES P. EDWARDS	8723 HESBY COURT, SAN DIEGO, CALIFORNIA 92129
4	DANIEL J. PIPPEL	13106 CAMINITO MAR VILLA, DEL MAR, CALIFORNIA 92014
5	JENNIFER D. VENABLE	739 N. RIOS AVENUE, SOLANA BEACH, CALIFORNIA 92075

PCT International Classification Number

C07D401/14;A61P11/06

PCT International Application Number

PCT/US2007/008216

PCT International Filing date

2007-03-30

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1	60/788,190	2006-03-31	U.S.A.