Title of Invention	"tPA MUTANT INCREASING PERMEABILITY OF THE BBB (BLOOD-BRAIN-BARRIER)"
Abstract	The invention relates to tPA mutant devoid of protease activity and uses thereof in compositions and methods for the treatment and prevention of pathologic conditions involving neurological injury or an ischemic disease or condition. More specifically, the invention relates to a Ser481 to Ala mutant of tPA and to compositions and combinations thereof for the treatment of stroke, acute brain injury and neurodegenerative disorders. The invention further provides methods and kits for the treatment of said disorders.

Title of Invention

"tPA MUTANT INCREASING PERMEABILITY OF THE BBB (BLOOD-BRAIN-BARRIER)"

Abstract

The invention relates to tPA mutant devoid of protease activity and uses thereof in compositions and methods for the treatment and prevention of pathologic conditions involving neurological injury or an ischemic disease or condition. More specifically, the invention relates to a Ser481 to Ala mutant of tPA and to compositions and combinations thereof for the treatment of stroke, acute brain injury and neurodegenerative disorders. The invention further provides methods and kits for the treatment of said disorders.

Full Text

Documents:

http://ipindiaonline.gov.in/patentsearch/GrantedSearch/viewdoc.aspx?id=j8KPXAQpJNzPnt+EwRhwnA==&loc=+mN2fYxnTC4l0fUd8W4CAA==

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Patent Number

270226

Indian Patent Application Number

7294/DELNP/2010

PG Journal Number

49/2015

Publication Date

04-Dec-2015

Grant Date

02-Dec-2015

Date of Filing

15-Oct-2010

Name of Patentee

HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD.

Applicant Address

P.O. BOX 12000, JERUSALEM 91120, ISRAEL

Inventors:

#	Inventor's Name	Inventor's Address
1	NUHA HIJAZI	31 NEVE SHALOM, D.N. SHIMSHON 99761, ISRAEL
2	ABD HIGAZI	31 NEVE SHALOM, D.N. SHIMSHON 99761, ISRAEL

PCT International Classification Number

C12N 9/72

PCT International Application Number

PCT/IL2009/000300

PCT International Filing date

2009-03-16

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1	190184	2008-03-16	Israel