Indian Patents. 271021:PROCESS FOR THE PREPARATION OF DIORGANOMAGNESIUM-CONTAINING SYNTHESIS AGENTS

Title of Invention	PROCESS FOR THE PREPARATION OF DIORGANOMAGNESIUM-CONTAINING SYNTHESIS AGENTS
Abstract	The present invention relates to a diorganomagnesium-containing synthesis means, a method for its preparation and the use of this synthesis means.

Full Text	Process for the preparation of diorganomagnesium-containing synthesis agents The present invention provides a diorganomagnesium-containing synthesis agent, a process for its preparation, and the use of this synthesis agent. The present invention provides in particular a process for the preparation of mixtures of diorganomagnesium-containing synthesis agents with alkali salts for use in organic and organometallic synthetic chemistry, for example in halogen/metal exchange reactions or transmetallation reactions, or in metallation reactions. Organomagnesium compounds are used in a variety of applications in chemical synthesis (H. G. Richey, Jr., Grignard Reagents New Developments, John Wiley and Sons, 2000; G. S. Silvermann, P. E. Rakita, Handbook of Grignard Reagents, Marcel Dekker Inc., 1996). In terms of reactivity, Grignard reagents RMgX and diorganomagnesium compounds R1R2Mg are very similar (K. Nutzel, Methoden der organischen Chemie, Metallorganische Verbindungen (Houben-Weyl, Ed.: E. Muller, O. Bayer), Thieme Verlag Stuttgart, 1973, Volume Xlll/2a, Edition 4, p. 197ff.). Mixtures of diorganomagnesium compounds with alkali-metal organyls in some cases exhibit higher reactivity, which is readily made use of in synthetic chemistry (K. Kitigawa, A. Inoue, H. Shinokubo, K. Oshima, Angew. Chem. 2000, 112, 2594; A. Inoue, K. Kitagawa, H. Shinokubo, K. Oshima, J. Org. Chem. 2001, 66, 4333; A. Inoue, K. Kitagawa, H. Shinokubo, K. Oshima, Tetrahedron 2000, 56, 9601). Accordingly, inter alia, mixtures of Grignard or dialkylmagnesium compounds and lithium chloride LiCI are disclosed as a highly potent reagent for halogen/metal exchange reactions. By reaction of these mixtures with, for example, aryl halides, new organomagnesium compounds are obtainable which cannot be prepared, or can be prepared only with difficulty, by other processes (P. Knochel et al., EP-A-04008081; P. Knochel et al., EP-A-1582524; P. Knochel et al., Angew. Chem. Int. Ed. 2003, 42, 4302; A. Krasovskiy et al., Angew. Chem. Int. Ed. 2004, 43, 3333; P. Knochel et al., Chem. Commun. 2004, 2288; P. Knochel et al.. Org. Lett. 2004, 6, 4215; P. Knochel, Chem. Commun. 2005, 543; P. Knochel, Angew. Chem. Int. Ed. 2005, 44, 1654; P. Knochel et al., Angew. Chem. Int. Ed. 2005, 44, 3133). The advantage of using such dialkylmagnesium/LiCI mixtures in halogen/metal exchange reactions instead of mixtures of alkylmagnesium halides and lithium chloride is that the rate of conversion is markedly higher, unactivated organic compounds can be converted and, in addition, only half the amount of dialkylmagnesium compound need be used, because both alkyl substituents are involved in the exchange reaction. The economy of a halogen/metal exchange reaction can therefore be increased considerably by using dialkylmagnesium/LiCI mixtures. However, the use of this method requires a diorganomagnesium compound to be available and to be mixed with a lithium salt. However, the preparation of diorganomagnesium-containing synthesis agents, on the one hand, and the mixing thereof with alkali salts, on the other hand, is complex according to the prior art. The known methods for the preparation of diorganomagnesium-containing synthesis agents are described hereinbelow. The transmetallation of diorganomercury compounds with magnesium yields diorganomagnesium compounds, as shown in Figure 1. However, a diorganomercury compound must be prepared and made available for this process, i Such mercury compounds are additionally extremely toxic (H. C. Holtkamp et al., J. Organomet. Chem. 1969, 19, 279). Figure 1: Transmetallation reaction for the preparation of R2Mg compounds: The reaction of organolithium compounds with organomagnesium halides yields diorganomagnesium compounds, with the formation of lithium halides, as shown in i Figure 2 (C. W. Kamienski et al., J. Organomet. Chem. 1967, 8, 542). By using an excess of organolithium compounds or Grignard compounds, mixtures of diorgano¬magnesium compounds and lithium organyls or Grignard compounds are formed. This method requires that a corresponding organolithium compound be available. However, many organolithium compounds are either not obtainable or have only limited stability in aprotic organic solvents or in ether-containing aprotic organic solvent mixtures. By the use of the above-described process, diorganomagnesium-containing synthesis agents are in most cases obtained in ether-containing solvent mixtures, which can impair the selectivity of a reaction in further reactions or can also impair the reactivity of the diorganomagnesium-containing synthesis agent. In some cases, depending on the coordination strength, the ether can be removed completely by distillation by addition of higher boiling hydrocarbons. This is possible, for example, in the preparation of dibutyl-(2)-magnesium. However, hydrocarbon has to be added continuously during the distillation. The preparation of diorganomagnesium compounds in only one solvent accordingly consumes a large amount of solvent and is therefore uneconomical. Mixtures of, for example, di-(2)-butylmagnesium with lithium chloride for use in halogen/metal exchange reactions cannot be prepared directly by reaction of 2-butylmagnesium chloride with 2-butyllithium when commercially available dilute solutions of 2-butyllithium (12% in cyclohexane) and of 2-butylmagnesium chloride (25% in tetrahydrofuran (THF)) are used, because the lithium chloride that forms precipitates in the cyclohexane-rich solvent mixture and is accordingly no longer available for accelerating exchange reactions. If THF, for example, is added to this suspension, the lithium chloride that forms goes into solution, but the di-(2)-butylmagnesium/LiCI mixtures that are obtained are so dilute that their use in exchange reactions is uneconomical. Although a more concentrated solution of 2- ) butyllithium in, for example, cyclohexane can be used in order to obtain the desired di-(2)-butylmagnesium/LiCI mixtures directly, such concentrates are pyrophoric, have only limited stability and are difficult to handle. In addition, ether cleavage is observed in the presence of ethers even at lower temperatures, which leads to undesirable secondary products and losses in yield. As is shown in Figure 3, organomagnesium halides are present in solution according to W. Schlenk in the following equilibrium (W. Schlenk et al, Berichte 1929, 62, 920; W. Schlenk, Berichte 1931, 64, 734): By the addition of specific solvents, such as, for example, pyridine. Crown ether, dioxan, tetramethylethylenediamine (TMEDA) or dimethyl ether (DME), the equilibrium is displaced in the direction towards the diorganomagnesium compound. After separation of the resulting poorly soluble magnesium halide, it is accordingly possible to obtain diorganomagnesium compounds or mixtures thereof with Grignard compounds, as is shown in Figure 4. However, it is known that the displacement of the equilibrium is greatly dependent on the choice of solvent, the temperature, the time of action of the solvent on the Grignard compound, and the concentration of the solution. Almost complete precipitation of the magnesium halide is possible only with difficulty. It is therefore technically demanding to obtain definite products in a reproducible manner. In addition, this process requires the use of exotic solvents which are used only rarely commercially and some of which are toxic or carcinogenic. Diorganomagnesium compounds can also be prepared by reaction of magnesium hydride MgHa with alkenes containing activated double bonds, as is shown in Figure 5: The yields of diorganomagnesium compounds prepared by this method are low. In addition, this process requires high pressures and temperatures. As a result, secondary reactions take place and the crude product must be purified in a technically complex manner. A further method is described in EP-B-0285374. Mixtures of lithium organyls and diorganomagnesium compounds are obtained by reaction of an alkyl halide with a mixture of, for example, lithium and magnesium in hydrocarbons containing from 0.05 to 2 molar equivalents of a Lewis base per mol of organometallic composition, as is shown in Figure 6: This process has the disadvantage that it is carried out in mixtures of hydrocarbons and Lewis bases, for example THF. The product is therefore present in a solvent mixture. This often has a disadvantageous effect in synthetic chemistry because, for example, changed selectivities or reactivities are obtained. In addition, it is I known that if the amount of Lewis base exceeds or falls short of a specified amount, poorer yields are obtained, for example owing to secondary reactions such as ether cleavage. Because of the higher reactivity of lithium in comparison with magnesium, an organolithium compound mainly accumulates in the reaction mixture at the beginning of the reaction. It is known, however, that many organolithium compounds, such as, for example, sec-butyllithium, have only limited stability in solvents containing Lewis bases and react with the Lewis base. Undesirable secondary products thereby form, and the yield falls accordingly. The process therefore has only limited usability. In addition, because of the poor solubility of lithium salts in solvents containing only small amounts of Lewis base, only synthesis agents that are low in or free of lithium salts are obtained according to this process, and such synthesis agents are not suitable for use in halogen/metal exchange reactions, for example. A further process is disclosed in US-A-5171467. Here too, the reaction takes place in solvent mixtures of hydrocarbons and ethers. The process is explained by way of example by means of Figure 7. Figure 7: Preparation of diorganomagnesium compounds via magnesium halides: As is shown, an organolithium compound is formed as an intermediate in the synthesis and is subsequently reacted with magnesium chloride. Anhydrous magnesium chloride must therefore be used in the synthesis in order to prevent partial hydrolysis of the organolithium compound, which would lead to a loss in yield. Anhydrous magnesium chloride must be prepared in situ in a technically complex manner or must be dried at high temperatures for a long time. Both operations have a disadvantageous effect on the economy of this method. In addition, a pure diorganomagnesium compound can be obtained only when an excess of dry magnesium halide is used. If magnesium halides are used in less than stoichiometric amounts, a mixture of a diorganomagnesium compound and a lithium organyl is formed. As has already been described above, it is known that many lithium organyls have only limited stability in ether-containing solvent mixtures because of ether cleavage. Secondary reactions occur, which result in undesirable secondary products and poorer yields. The process therefore has only limited usability. Magnesium chloride is only sparingly soluble in mixtures of hydrocarbons and ethers, which results in a slower reaction of the organolithium compound with magnesium chloride. Long reaction times are necessary, which favours secondary reactions, for example ether cleavage. In addition, only diorganomagnesium-containing synthesis agents that are low in or free of lithium salts are obtained according to this process, which synthesis agents have only limited usability, as has been described. In addition to these methods there are further methods, but these are suitable only for the synthesis of specific organomagnesium compounds. The direct preparation of organomagnesium compounds from magnesium and organic halides is possible only in rare cases. For example, it is possible in the case of di-(2)-butylmagnesium, butylethylmagnesium, butyloctylmagnesium, n-butyl-sec-butylmagnesium. However, these compounds can be prepared only under conditions which are very disadvantageous in terms of energy. For example, some of the alkyl halides used for the synthesis must be added under high pressure to the boiling suspension of solvent and very fine magnesium powder. Because secondary reactions also take place at the very high reaction temperatures, gaseous alkenes from p-H elimination reactions are always given off into the surroundings. For example, it is known that relatively large amounts of butene are formed in the synthesis of dibutylmagnesium. It is also known that some of the dialkylmagnesium compounds prepared in this manner have poor solubility in the solvent used. Therefore, octyl chloride must always be added where possible to form octyl-containing dialkylmagnesium compounds. Although the solubility of the compound is thereby increased, it is not possible to prepare a definite product in this manner. It is likewise known that solutions of the dialkylmagnesium compounds so prepared always have a very high viscosity, through the formation of coordination polymers, so that auxiliary agents such as aluminium alkyls must in principle be added in order to lower the viscosity. However, this impairs the purity considerably. In addition, long reaction times are necessary owing to the slow oxidative addition, shown in Figure 8, of the two necessary equivalents of alkyl halide to magnesium (Magnesium Alkyls from Akzo Nobel, 1999: Metal Alkyls from Akzo Nobel, 2003; M. de Vries, Stamicarbon N. V. 1969, US-A-3737393; Zn-Zusatze: G. W. Knight, L. 5 Jackson, D. E. Mach, Dow Chemical Comp. 1975, US-A- 4213880; SiOR4-Zusatz: Akzo Nobel 1997, WO-A-99/09035; GaR3, lnR3, RLi: L. W. Fannin, D. B. Malpass, R. Sanchez; Texas Alkyls 1980, US-A-4299781; C. W. Kamiensky, B. J. McElroy, R. O. Bach, Lithium Corp. of America 1976 US-A-4069267; L. W. Fannin, D. B. Malpass, Texas Alkyls 1977, US-A-4127507; D. B. Malpass, D. W. Webb, Texas Alkyls 1984, US-A-4547477). Figure 8: Synthesis of R2Mg compounds from magnesium and organic halides using the example of di-(2)-butylmagnesium: Mixtures of diorganomagnesium compounds and alkali-metal organyls are obtained according to Figure 9 by reaction of diorganomagnesium compounds with alkali metals (D. B. Malpass, J. F. Eastham, J. Org. Chem. 1973,21,3718). I Figure 9: Mixtures of diorganomagnesium compounds and alkali-metal organyls: 3 R2Mg + 2 M ► 2 RsMgM + Mg 12 R2Mg + 2 RM 5 (sec-Bu)2Mg + 6 Li - 2 (sec-Bu)5MgLi3 + 3 Mg 12 (sec-Bu)2Mg + 6 sec-BuLi R = organic fragment, M = alkali metal However, this process requires that a diorganomagnesium compound be available. As has been shown, however, the preparation of such compounds by methods of the prior art is difficult. 5 The speed of halogen/metal exchange reactions can be increased drastically by the use of, for example, mixtures of Grignard compounds or diorganomagnesium compounds with lithium salts. By the addition of lithium salts to the above-described compounds It is possible to prepare reagents which cannot be prepared commercially, or which can be prepared commercially only with difficulty, by other 3 processes owing to secondary reactions or long reaction times. In all the above-described possible methods of preparing diorganomagnesium compounds that do not use lithium organyls or lithium metal as starting material, a lithium salt, for example lithium chloride, must therefore be added in a further process step. Because of the poor solubility of the lithium salt in the solvent or solvent mixture used, a solvent exchange must additionally be carried out in some cases. If organomagnesium compounds are prepared via lithium organyls or using lithium metal, a lithium salt forms in situ. However, because it is necessary in the described processes to work in hydrocarbons or in ether/hydrocarbon mixtures owing to the implementability of the methods, the lack of stability or lack of solubility of the resulting lithium organyl, a large part of the lithium salt that forms precipitates. Although this can be brought into solution again by the addition of polar solvents, dilute solutions form, which are uneconomical to use in synthetic chemistry. In order nevertheless to obtain lithium-salt-containing mixtures, a solvent exchange is necessary in this case too in a further process step. In addition, the availability and stability of an organolithium compound are required in some cases. Lithium chloride is very hygroscopic, which makes its subsequent introduction into organomagnesium compounds difficult. If water-containing or slightly moist lithium chloride is used, partial hydrolysis of the organomagnesium compounds takes place. Undesirable secondary products form as a result, and the yield of organomagnesium compounds falls accordingly. All the mentioned processes for the preparation of diorganomagnesium-containing synthesis agents or mixtures thereof with alkali-metal salts are either expensive, require the handling of pyrophoric or even toxic compounds, use as starting materials organometalllc compounds which in some cases are not available commercially or organometalllc compounds which have only limited stability, require a plurality of process steps, lead to the formation of undesirable secondary products or have only limited usability. The object of providing an efficient, simple and inexpensive process, which can be carried out commercially, for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali salts has accordingly not hitherto been achieved. ) The object of the present invention is, therefore, to provide a process for the preparation of diorganomagnesium-containing synthesis agents which overcomes the disadvantages of the prior art. It is a particular object of the present invention to provide a process which yields identically or differently substituted diorganomagnesium-containing synthesis agents in only one specified solvent or in specified solvent mixtures, and which yields directly alkali-salt-containing solutions, but also solutions which are low in or free of alkali-metal salts, of diorganomagnesium-containing synthesis agents in specific solvents or solvent mixtures. Surprisingly, the object is achieved according to the invention by the features of the main claim. Preferred embodiments will be found in the subsidiary claims. Surprisingly, the process according to the invention permits the preparation of a large number of diorganomagnesium compounds, such as, for example, dialkyi-, dialkenyl-, dialkynyl-, diaryl-, diheteroaryl-, alkylalkenyl-, alkylalkynyl-, alkylaryl-, alkylheteroaryl-, alkenylalkynyl-, alkenylaryl-, alkenylheteroaryl-, alkynylaryl- or alkynylheteroaryl-magnesium compounds, or mixtures thereof with alkali-metal organyls or Grignard compounds, or mixtures with alkali-metal salts, in only one specific solvent or in specific solvent mixtures. By means of the process according to the invention, alkali-salt-containing solutions of diorganomagnesium-containing synthesis agents or solutions that are low in or free of alkali-metal salts can also be prepared directly. The diorganomagnesium-containing synthesis agents prepared according to the invention, or mixtures thereof with alkali-metal salts, can be used in the preparation of a large number of in some cases highly functionalised substances, such as pharmaceuticals, natural substance derivatives, polymer materials, agrochemicals, speciality chemicals and catalysts, for example in halogen/metal exchange reactions or metallation reactions, for example ortho-metallation reactions, or transmetallation reactions, for example in the preparation of diorganozinc compounds or organozinc halides. It has been found, surprisingly, that the desired diorganomagnesium-containing synthesis agents, or mixtures thereof with alkali-metal salts, are formed directly by reaction of a compound of the general formula RMgX - or of a plurality of compounds of the general formula R'MgX, R2MgX and R3MgX - and a compound the general formula RX - or a plurality of compounds of the general formula R1X, R2X and R3X - with alkali metal or with a mixture of alkali metal and magnesium. This embodiment of the process according to the invention is explained by the general reaction formula in Figure 10, without limiting the invention thereto. Alkali metal within the scope of the invention is the pure alkali metal and also mixtures or alloys thereof with other alkali metals. Lithium or mixtures or alloys of lithium and another alkali metal, preferably sodium, are preferably used as the alkali metal. The content of lithium in the mixtures or alloys is from 50 to 99.99 wt.%, preferably from 80 to 99.99 wt.%, more preferably from 90 to 99.99 wt.%. However, other alkali metals can also be used. The process according to the invention is explained in detail using the example of the following formula (Figure 10): 2n M + (n+m) RX + m Mg + (p-m) RMgX *► n R2Mg + n MX R = organic fragment, X = halogen; M = lithium or lithium-containing mixture or alloy RMgX = Grignard compound or mixture of x • R1MgX and y • R1MgX Grignard compounds , wherein x + y = (p - m) and x and y are chosen independently of one another between 0 and (p - m) RX = organic halide or mixture of x • R1X and y • R2X organic halides, wherein x + y = (n+m) and x and y are chosen independently of one another between 0 and (n+m) The process according to the invention is generally carried out as follows: I The alkali metal or a mixture of alkali metal and magnesium is suspended in an aprotic organic solvent or solvent mixture. The desired diorganomagnesium-containing synthesis agent or a mixture thereof with alkali-metal salts is formed by addition of a Grignard compound RMgX - or of a plurality of Grignard compounds R'MgX, R1MgX and R1MgX - and of a compound of the general formula RX - or of i a plurality of compounds of the general formula R1X, R2X and R3X - separately or mixed beforehand. The compounds of the general formulae R'MgX, R1MgX and R1MgX are preferably added in solution in an aprotic organic solvent or solvent mixture, more preferably in the solvent or solvent mixture in which the alkali metal or the mixture of alkali metal and magnesium is suspended. ) The molar ratio of the total amount of alkali metal to the total amount of compounds of the general formulae RX, R'X, R1X and R1X is 2n/(n+m), the molar ratio of magnesium to the total amount of compounds of the general formulae RX, R1X, R1X and R1X is m/(n+m) and the molar ratio of the total amount of compounds of the general formula RMgX, R1MgX, R1MgX and R1MgX to the total amount of compounds of the general formulae RX, R1X, R1X and R1X is (p-m)/(n+m), wherein n is chosen between n = 0.1 and n = 5, preferably between n = 0.8 and n = 3, and m is chosen between m = 0 and m = 5, preferably between m = 0 and m = 3, and wherein (p-m) > 0 and p is chosen between p = 0 and p = 10, preferably between p = 0 and p = 6. In a preferred embodiment according to the invention for the preparation of diorganomagnesium compounds and mixtures thereof with alkali-metal salts, n is chosen between n = 0.8 and n = 1.8, preferably between n = 0.8 and n = 1.2, and m is chosen between m = 0 and m = 1, preferably between m = 0 and m = 0.5, and p is chosen between p = 0 and p = 3, preferably between p = 0 and p = 1.5, wherein (p-m) > 0. In a preferred embodiment according to the invention for the preparation of mixtures of diorganomagnesium compounds and Grignard compounds and mixtures thereof with alkali-metal salts, p for n > m is preferably p > n and for n m. In a preferred embodiment according to the invention for the preparation of mixtures of diorganomagnesium compounds and alkali-metal organyls and mixtures thereof with alkali-metal salts, preferably n > m and p In a preferred embodiment according to the invention for the preparation of identically substituted diorganomagnesium-containing synthesis agents, a Grignard compound RMgX and an organic halide RX are used. In a preferred embodiment according to the invention for the preparation of differently substituted diorganomagnesium-containing synthesis agents, x • R1MgX and y • R1MgX Grignard compounds and organic halide z • R1X are used, wherein x and y are chosen independently of one another between 0 and (p-m) and wherein the sum of x+y = (p-m) and wherein z is chosen between 0 and (n+m). In a further preferred embodiment according to the invention for the preparation of differently substituted diorganomagnesium-containing synthesis agents, x • R1X and y • R1X organic halides and Grignard compound x • R1MgX are used, wherein X and y are chosen independently of one another between 0 and (n+m) and wherein the sum of x+y = (n+m) and wherein z is chosen between 0 and (p-m). in a further preferred embodiment according to the invention, the ratio of the molar rate of addition of the total amount of organic halides RX, R1X, R1X, R1X to the molar rate of addition of the total amount of Grignard compounds RMgX, R1MgX, R1MgX, R1MgX is from 1:50 to 50:1, preferably from 1:20 to 20:1, particularly preferably from 1:10 to 10:1, very particularly preferably from 1:5 to 5:1. If rates of addition other than those specified above are chosen there is the possibility of secondary reactions such as, for example, ether cleavage, in particular when the organic halide is added markedly more rapidly than the Grignard compound. Diorganomagnesium-containing synthesis agents within the scope of the invention are diorganomagnesium compounds R2Mg or Rx1Ry1Mg and mixtures thereof with z Grignard compounds RMgX or R1MgX or z alkali-metal organyls RM or R1M. The molar mixing ratio with Grignard compounds or alkali-metal organyls is determined by z, z is in the range from 0 to 10, preferably from 0 to 4. The sum of the coefficients x and y is 2, and they are within the range between 0 and 2, independently of one another. R, R\ R1 and R1 are chosen independently of one another and are as defined hereinbelow. Depending on the solvent or solvent mixture used, mixtures of diorganomagnesium-containing synthesis agents and alkali salt halides are obtained that differ in terms of the ratio of alkali salt to organomagnesium compound. Lithium or lithium-containing mixtures or alloys are preferably used in the form of a metal powder, a metal dispersion or metal granules, particularly preferably in the form of a metal powder or a metal dispersion. Magnesium is preferably used in the form of turnings, flakes or powders. Grignard compounds RMgX and organic halides RX are preferably added to a suspension of the alkali metal or of a mixture of alkali metal and magnesium in an aprotic organic solvent or solvent mixture. For the preparation of the diorganomagnesium-containing synthesis agents according to the invention in solvent mixtures of ethers and hydrocarbons, one or more different Grignard compounds RMgX in ethers or in mixtures of ethers and hydrocarbons are used in a further embodiment. Furthermore, the alkali metal or the alkali metal and magnesium is preferably suspended in an aromatic or aliphatic hydrocarbon. The ethers used can be removed by methods of the prior art when the reaction is complete, for example by distillation under normal pressure, under reduced pressure, by vacuum distillation or by concentration by evaporation. Solutions of diorganomagnesium-containing synthesis agents that are low in or free of alkali-metal salts are thus formed. For the preparation of diorganomagnesium-containing synthesis agents containing alkali-metal salts, for example for use in halogen/metal exchange reactions or metallation reactions, solely ethereal solvents are used in a preferred embodiment, preference being given to cyclic ethers and particularly preferably to THF and 2-methyl-THF. The process for the preparation of diorganomagnesium-containing synthesis agents is preferably carried out with the exclusion of air and moisture, preferably in an inert gas atmosphere, particularly preferably in a nitrogen or argon atmosphere. The process according to the invention can be carried out at temperatures from -100°C to the boiling point of the reaction suspension; it is preferably carried out in a temperature range from -15°C to the boiling point of the reaction suspension, particularly preferably from 0°C to 60°C. The diorganomagnesium-containing synthesis agent according to the invention is obtained in addition to solids, which in a preferred embodiment are separated off by methods of the prior art. Methods of the prior art are, for example, decantation, filtration or centrifugation. The resulting solutions of diorganomagnesium-containing synthesis agents are either free of alkali-metal salt or contain alkali-metal salt, depending on the solvent or solvent mixture, and can be used directly in organic or organometallic synthetic chemistry. In the Grignard compounds of the general composition RMgX, R1MgX, R1MgX and R1MgX and in the organic halides RX, RX, R1X and R1X and in the diorganomagnesium compounds R2Mg and Rx3Ry3Mg and mixtures thereof with all - R, R\ R3 and R3, which may be identical or different, can be selected from H, saturated, unsaturated, branched, unbranched, functionalised, unfunctionalised, aliphatic, cyclic, heterocyclic or aromatic organic fragments, preferably fragments having from 1 to 80, particularly preferably from 1 to 40, very particularly preferably from 1 to 20 carbon atoms, and - R can generally also represent R\ R3 and R3, and - X is selected from chlorine, bromine, iodine, tosylate and triflate, preferably from chlorine, bromine and iodine, and - M is an alkali metal. In particular, R, R\ R3 and R3, which may be identical or different, can be selected from methyl, ethyl, cyclopropyl, cyclopentyl, cyclohexyl, phenyl, benzyl and heteroaryl fragments as well as branched and unbranched propyl, butyl, pentyl, hexyl, heptyl, octyl fragments. Preferred aprotic organic solvents are aliphatic or aromatic hydrocarbons, heterocycles, ethers, amines, nitriles or mixtures thereof. Within the scope of the invention, the term aliphatic hydrocarbons includes cyclic, saturated, unsaturated, branched and unbranched hydrocarbons. Preference is given to saturated or cyclic, branched or unbranched hydrocarbons having from 5 to 20 carbon atoms, particularly preferably n-pentane, n-hexane, n-heptane, n-octane or the isomers thereof, cyclopentane, cyclohexane and methylcyclohexane. Within the scope of the invention, the term ethers includes acyclic, cyclic, saturated, unsaturated, branched, unbranched, identically substituted and differently substituted ethers having at least one oxygen atom, preferably having from one to four oxygen atoms. Also preferred as ethers are dimethyl ether, diethyl ether, dibutyl ether, dimethoxyethane, diethoxymethane, polyethylene glycol, methyl tert-butyl ether, cyclopentyl methyl ether, dioxan, tetrahydrofuran and 2-methyl-tetrahydrofuran, and particular preference is given to THF and 2-methyl-THF. Within the scope of the invention, the term amines includes acyclic, cyclic, saturated, unsaturated, branched, unbranched, identically substituted and differently substituted amines having at least one nitrogen atom, preferably having from one to four nitrogen atoms, preference being given to N,N-tetramethylethylenediamine. Within the scope of the invention, the term aromatic hydrocarbons includes unsubstituted, monosubstituted and polysubstituted aromatic compounds. Benzene, toluene, ethylbenzene, cumene and xylene and the isomers thereof are preferably used. Within the scope of the invention, heterocycles are substituted, unsubstituted, aromatic, saturated and unsaturated cyclic compounds which consist in the ring of at least four carbon atoms and at least one atom from the group of the heteroatoms oxygen, sulfur and nitrogen, preference being given to from four to six carbon atoms and from one to three heteroatoms, particular preference being given to pyridine, THF and 2-methyltetrahydrofuran. In detail, the invention provides: a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, characterised in that an alkali metal or mixtures or alloys of alkali metals, a Grignard compound of the general formula RMgX or a plurality of Grignard compounds of the general formulae R3MgX, R3MgX and R3MgX, an organic halide of the general formula RX or a plurality of organic halides of the general formulae R3X, R3X and R3X are reacted with one another; a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts using alkali metals or mixtures or alloys of alkali metals, Grignard compounds of the general formula RMgX and organic halides of the general formula RX, wherein the diorganomagnesium-containing synthesis agents are formed directly from the added reagents; a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein magnesium is additionally also used; a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein alkali metal is to be understood as being lithium or mixtures or alloys consisting of lithium and another alkali metal, preferably sodium, wherein the amount of lithium in the mixtures or alloys is from 50 to 99.99 wt.%, preferably from 80 to 99.99 wt.%, more preferably from 90 to 99.99 wt.%; a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein the alkali metal or the alkali metal and magnesium is/are suspended in an organic aprotic solvent or solvent mixture and a compound of the general formula RMgX or a plurality of compounds of the general formulae R1MgX, R1MgX and R1MgX - separately or mixed beforehand - and a compound of the general formula RX or a plurality of compounds of the general formulae R1X, R1X and R1X - separately or mixed beforehand - are added; a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein there are added compounds of the general formulae RMgX, R1MgX, R1MgX and R1MgX dissolved in an aprotic organic solvent or solvent mixture, preferably in the solvent or solvent mixture in which the alkali metal or the alkali metal and magnesium is/are suspended; a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein the molar ratio of the total amount of alkali metal to the total amount of compounds of the general formulae RX, R1X, R1X and R1X is 2n/(n+m), the molar ratio of magnesium to the total amount of compounds of the general formulae RX, R'X, R1X and R1X is m/(n+m) and the molar ratio of the total amount of compounds of the general formulae RMgX, R'MgX, R1MgX and R1MgX to the total amount of compounds of the general formulae RX, R1X, R1X and R1X is (p-m)/(n+m), wherein n is chosen between n = 0.1 and n = 5, preferably between n = 0.8 and n = 3, and m is chosen between m = 0 and m = 5, preferably between m = 0 and m = 3, and (p-m) > 0 and p is chosen between p = 0 and p = 10, preferably between p = 0 and p = 6; a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein in a preferred embodiment for the preparation of diorganomagnesium compounds and mixtures thereof with alkali-metal salts n is chosen between n = 0.8 and n = 1.8, preferably between n = 0.8 and n = 1.2, and m is chosen between m = 0 and m = 1, preferably between m = 0 and m = 0.5, and (p-m) > 0 and p is chosen from a range between p = 0 and p = 3, preferably between p = 0 and p = 1.5; a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein for the preparation of mixtures of diorganomagnesium compounds and Grignard compounds and mixtures thereof with alkali-metal salts for n m preferably p > n and for n a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein for the preparation of mixtures of diorganomagnesium compounds and alkali-metal organyls and mixtures thereof with alkali-metal salts n > m and p n; a process for the preparation of identically substituted diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein a Grignard compound RMgX and an organic halide RX are used; a process for the preparation of differently substituted diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein there are used for the preparation x • R1MgX and y . R1MgX Grignard particularly preferably between 1:10 and 10:1, very particularly preferably between 1:5 and 5:1; a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein the lithium or the lithium-containing alloys or mixtures are used in the form of a metal powder, a metal dispersion or metal granules, preferably in the form of a metal powder or a metal dispersion; a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein the magnesium is preferably used in the form of turnings, flakes or powders; a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein the Grignard compounds RMgX or R1MgX, R1MgX and/or R1MgX and the organic halides RX or R1X, R1X and/or R1X are added to a suspension of the alkali metal or of the alkali metal and magnesium; a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts in solvent mixtures of ethers and hydrocarbons, wherein there are used for the preparation one or more different Grignard compounds RMgX or R1MgX, R1MgX and/or R1MgX in ethers or, preferably, in mixtures of ethers and hydrocarbons and wherein the alkali metal or the alkali metal and magnesium is/are preferably suspended in an aromatic or aliphatic hydrocarbon, and wherein, when the reaction is complete, the ethers used can be removed by methods of the prior art, for example by distillation under normal pressure, under reduced pressure, by vacuum distillation or by concentration by evaporation, and wherein solutions of organomagnesium compounds that are low in or free of alkali-metal salts are formed; a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein for the preparation of diorganomagnesium-containing synthesis agents containing alkali-metal salts, for example for use in halogen/metal exchange reactions or metallation reactions, there are used solely ethereal solvents, preference being given to the use of cyclic ethers and particularly preferably THF and 2-methyl-THF; a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein the processes are carried out with the exclusion of air and moisture, preferably in an inert gas atmosphere, particularly preferably in a nitrogen or argon atmosphere; a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein the process according to the invention is carried out at temperatures of from -100°C to the boiling point of the reaction suspension, preferably at temperatures of from -15°C to the boiling point of the reaction suspension, particularly preferably from 0°C to 60°C; a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein the corresponding diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts are separated from precipitated solids by methods of the prior art, preferably decantation, filtration or centrifugation; a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein R, R1 R1 and R1 are in all cases selected independently of one another from H, saturated, unsaturated, branched, unbranched, functionalised, unfunctionalised, aliphatic, cyclic, heterocyclic or aromatic organic fragments, wherein in particular saturated, unsaturated, branched, unbranched, functionalised, unfunctionalised, aliphatic, cyclic, heterocyclic or aromatic organic fragments having from 1 to 80 carbon atoms are preferred, wherein saturated, unsaturated, branched, unbranched, functionalised, unfunctionalised, aliphatic, cyclic, heterocyclic or aromatic organic fragments having from 1 to 40 carbon atoms are preferred, wherein saturated, unsaturated, branched, unbranched, functionalised, unfunctionalised, aliphatic, cyclic, heterocyclic or aromatic organic fragments having from 1 to 20 carbon atoms are particularly preferred, and wherein branched and unbranched methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, cyclopropyl, cyclopentyl, cyclohexyl, phenyl, benzyl and heteroaryl fragments are particularly preferred, and X is selected from chlorine, bromine, iodine, tosylate and triflate, preferably from chlorine, bromine and iodine; a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein aprotic organic solvents are used; a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein aliphatic or aromatic hydrocarbons, heterocycles, ethers, amines, nitriles or mixtures thereof are used; a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein there are used as aliphatic hydrocarbons cyclic, saturated, unsaturated, branched and unbranched hydrocarbons, preferably saturated or cyclic, branched or unbranched hydrocarbons having from 5 to 20 carbon atoms, particularly preferably n-pentane, n-hexane, n-heptane, n-octane or the isomers thereof, cyclopentane, cyclohexane and methylcyclohexane; a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein there are used as ethers cyclic, saturated, unsaturated, branched, unbranched, identically substituted and differently substituted ethers having at least one oxygen atom, preferably having from one to four oxygen atoms, particularly preferably dimethyl ether, diethyl ether, dibutyl ether, dimethoxyethane, diethoxymethane, methyl tert-butyl ether, polyethylene glycol, cyclopentyl methyl ether, dioxan, tetrahydrofuran and 2-methyltetrahydrofuran; a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein there are used as amines cyclic, aliphatic, saturated, unsaturated, branched, unbranched, identically substituted and differently substituted amines having at least one nitrogen atom, preferably having from one to four nitrogen atoms, particular preference being given to N,N-tetramethylethylenediamine; a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein there are used as aromatic hydrocarbons unsubstituted, monosubstituted and polysubstituted aromatic compounds, preferably benzene, toluene, ethylbenzene, cumene and/or xylenes or the isomers thereof; a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein there are used as heterocycles substituted, unsubstituted, aromatic, saturated and unsaturated cyclic compounds which consist in the ring of at least four carbon atoms, preferably from four to six carbon atoms, and at least one atom, preferably from one to three atoms, from the group of the heteroatoms oxygen, sulfur and nitrogen, wherein THF, 2-methyl-THF and pyridine are particularly preferred; a process for the preparation of identically or differently substituted dialkyi-, dialkenyl-, dialkynyl-, diaryl-, diheteroaryl-, alkylalkenyl-, alkylalkynyl-, alkylaryl-, alkylheteroaryl-, alkenylalkynyl-, alkenylaryl-, alkenylheteroaryl-, alkynylaryl- or alkynylheteroaryl-magnesium compounds or mixtures thereof with alkali salts, Grignard compounds RMgX or organolithium compounds RLi; a process for the preparation of identically or differently substituted di-n-alkyi-, di-sec-alkyi-, di-iso-alkyi-, di-tert-alkyi-, di-cycloalkyi-, di-aryl- and di-heteroaryl-magnesium compounds or mixtures thereof with alkali salts, Grignard compounds RMgX or organolithium compounds RLi; a process for the preparation of dimethylmagnesium, diethylmagnesium, di- isopropylmagnesium, di-n-propylmagnesium, di-n-butylmagnesium, di-sec- butylmagnesium, di-isobutylmagnesium, di-tert-butylmagnesium, di-cyclo- propylmagnesium, di-cyclo-pentylmagnesium, di-cyclo-hexylmagnesium, di-n- pentylmagnesium, di-n-hexylmagnesium, diphenylmagnesium, dibenzylmagnesium, n-butyl-n-octylmagnesium, n-butyl-ethylmagnesium, s-butyl-ethylmagnesium or s-butyl-n-butylmagnesium or mixtures thereof with alkali salts, Grignard compounds RMgX or organolithium compounds RLi; the use of the diorganomagnesium-containing synthesis agents prepared according to the invention, and of mixtures thereof with alkali salts, in synthetic chemistry; the use of the diorganomagnesium-containing synthesis agents prepared according to the invention, and of mixtures thereof with alkali salts, in organic chemistry and organometallic chemistry; the use of the diorganomagnesium-containing synthesis agents prepared according to the invention, and of mixtures thereof with alkali salts, in halogen/ metal exchange reactions; the use of the diorganomagnesium-containing synthesis agents prepared according to the invention, and of mixtures thereof with alkali salts, in metallation reactions, preferably in ortho-metallation reactions; the use of the diorganomagnesium-containing synthesis agents prepared according to the invention, and of mixtures thereof with alkali salts, in transmetallation reactions; the use of the diorganomagnesium-containing synthesis agents prepared according to the invention, and of mixtures thereof with alkali salts, in the preparation of organozinc halides or diorganozinc compounds; the use of the diorganomagnesium-containing synthesis agents prepared according to the invention, and of mixtures thereof with alkali salts, in the preparation of magnesium alcoholates and magnesium halides; a diorganomagnesium compound Rx1Ry1Mg in the form of a solution in an ether-containing solvent, wherein it is present in admixture with lithium halides and/or Grignard compounds RMgX and/or alkali-metal organyls RM and the molar ratio of diorganomagnesium compounds to lithium halide is from 1:0.1 to 1:2 and the molar mixing ratio of diorganomagnesium compound and Grignard compound or alkali-metal organyl is from 1:0.15 to 1:4 and the sum of x+y = 2 and X and y are chosen independently of one another from the range between 0 and 2; a solution of diorganomagnesium compounds Rx1Ry1Mg and lithium halides selected from the group lithium chloride, lithium bromide and lithium iodide in a tetrahydrofuran- or 2-methyltetrahydrofuran-containing solvent, and mixtures thereof with Grignard compounds RMgX or alkali-metal organyls RM, wherein R, R1 and R1 are chosen independently of one another from secondary alkyl groups, preferably sec-butyl, isopropyl, cyclopropyl, cyclopentyl, cyclohexyl, and the molar ratio of Rx1Ry1Mg to the lithium halide is in the range from 1:0.1 to 1:2 and the molar mixing ratio of diorganomagnesium compound and Grignard compound or alkali-metal organyl is from 1:0.15 to 1:4 and the sum x+y = 2 and x and y are chosen independently of one another from the range between 0 and 2; a solution of diorganomagnesium compounds Rx1Ry1Mg and lithium halides selected from the group lithium chloride, lithium bromide and lithium iodide in a tetrahydrofuran- or 2-methyltetrahydrofuran-containing solvent, and mixtures thereof with Grignard compounds RMgX or alkali-metal organyls RM, wherein R, R1 and R1 are chosen independently of one another from methyl, ethyl, isopropyl, n-propyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, n-octyl, cyclopropyl, cyclopentyl, cyclohexyl, phenyl, benzyl, and the molar ratio of Rx1Ry1Mg to the lithium halide is in the range from 1:0.1 to 1:2 and the molar mixing ratio of diorganomagnesium compound and Grignard compound or alkali-metal organyl is from 1:0.15 to 1:4 and the sum x+y = 2 and X and y are chosen independently of one another from the range between 0 and 2; a solution of diorganomagneslum compounds Rx1Ry1Mg and lithium halides selected from the group lithium chloride, lithium bromide and lithium iodide in tetrahydrofuran or 2-methyltetrahydrofuran, and mixtures thereof with Grignard compounds RMgX or alkali-metal organyls RM, wherein R, R1 and R1 are chosen independently of one another from methyl, ethyl, isopropyl, n-propyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, n-octyl, cyclopropyl, cyclopentyl, cyclohexyl, phenyl, benzyl, and the molar ratio of Rx1Ry1Mg to the lithium halide is in the range from 1:0.1 to 1:2 and the molar mixing ratio of diorganomagneslum compound and Grignard compound or alkali-metal organyl is from 1:0.15 to 1:4 and the sum x+y = 2 and x and y are chosen independently of one another from the range between 0 and 2; a solution of diorganomagneslum compounds Rx1Ry1Mg and lithium halides selected from the group lithium chloride, lithium bromide and lithium iodide in solvent mixtures of hydrocarbons and ethers, and mixtures thereof with Grignard compounds RMgX or alkali-metal organyls RM, wherein R, R"" and R1 are chosen independently of one another from methyl, ethyl, isopropyl, n-propyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, n-octyl, cyclopropyl, cyclopentyl, cyclohexyl, phenyl, benzyl, and the molar ratio of Rx1Ry1Mg to the lithium halide is in the range from 1:0.05 to 1:2 and the molar mixing ratio of diorganomagneslum compound and Grignard compound or alkali-metal organyl is from 1:0.05 to 1:4 and the sum x+y = 2 and x and y are chosen independently of one another from the range between 0 and 2, and wherein the molar ratio of ether to diorganomagneslum compound is from 0.02:1 to 50:1; a solution of diorganomagneslum compounds Rx1Ry1Mg and lithium halides selected from the group lithium chloride, lithium bromide and lithium iodide in solvent mixtures of dimethyl ether, diethyl ether, dibutyl ether, methyl tert-butyl ether, cyclopentyl methyl ether, tetrahydrofuran or 2-methyltetrahydrofuran and toluene, cumene, xylenes, pentane, hexane, heptane, octane, cyclohexane or methylcyclohexane, and mixtures thereof with Grignard compounds RMgX or alkali-metal organyls RM, wherein R, R1 and R1 are chosen independently of one another from methyl, ethyl, isopropyl, n-propyl, n-butyl, isobutyl sec-butyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, n-octyl, cyclopropyl, cyclopentyl, cyclohexyl, phenyl, benzyl, and the molar ratio of Rx1Ry1Mg to the lithium halide is in the range from 1:0.05 to 1:2 and the molar mixing ratio of diorganomagnesium compound and Grignard compound or -metal organyl is from 1:0.05 to 1:4 and the sum x+y = 2 and x and y are chosen independently of one another from the range between 0 and 2, and wherein the molar ratio of ether to diorganomagnesium compound is from 0.02:1 to 50:1. The invention Is explained by means of the following examples, without being limited thereto. To illustrate the efficiency of the process according to the invention, the preparation of di-sec-butylmagnesium and mixtures thereof with sec-BuLi or sec-BuMgCI and LiCI is chosen. The preparation of this compound according to the prior art, for example by oxidative addition of two equivalents of sec-butyl chloride to magnesium, leads, as has been described, to p-H elimination and various secondary products. In addition, high process temperatures and long reaction times are necessary. Tests for the preparation of {sec-Bu)2Mg by transmetallation with sec-BuLi result in solvent mixtures. If lithium-chloride-containing solutions are to be obtained directly by reaction of sec-BuMgCI with sec-BuLi, it is necessary to work with sec-BuLi concentrate, which has only limited stability and is also pyrophoric. If the synthesis of sec-Bu2Mg/LiCI mixtures with sec-BuMgCI and sec-BuLi concentrate is carried out in THF at 0°C, for example, THF cleavage is additionally observed, so that the product solution is contaminated. All tests are carried out in an argon atmosphere using Schlenk techniques. Commercial raw materials were used. With regard to sec-BuMgCI, various batches in the form of approximately 25% solutions in THF are used. The precise content and the composition of the batches are determined by wet analysis. With regard to lithium, lithium metal having different sodium contents was used. The sodium content is shown in Fig. 1, Table 1. The test parameters, analytical results and evaluations of the examples relating to the preparation according to the invention of organomagnesium compounds are summarised in Figs. 1 and 2, Tables 1 and 2. In the examples, R = sec-butyl. Where indicated, samples were taken during the reaction and examined by wet analysis. This was not taken into account when determining the yield, so that where samples were taken, the yields indicated in the tables are lower according to the number of samples. The magnesium content was determined by complexometry, the chloride content by argentometry and the total base content by acidimetry after hydrolysis. The active base was determined according to Watson-Eastham using 2,2'-biquinoline as indicator. Examples 1 to 13: Diorganomagnesium-containing synthesis agents via lithium, sec-butyl chloride and sec-butylmagnesium chloride, in some cases with magnesium, according to Figure 10: General procedure described by means of Example 1: 24.0 g (259 mmol) of sec-butyl chloride and 81.0 g (166 mmol) of sec-butylmagnesium chloride (in the form of an approximately 25% solution in THF) are added in the course of 125 minutes, at a reaction temperature of 25°C, to a suspension of 3.00 g (432 mmol) of lithium metal and 1.73 g (71 mmol) of coarse magnesium powder in 149 g of THF. After a post-reaction time of 60 minutes at 25°C, the resulting suspension is filtered and the residue is washed with THF and then dried in vacuo. Yield original solution: 221.4 g of a brown solution; washing solution: 86.44 g. Examples 2 to 13 were carried out analogously to Example 1 according to the experimental parameters indicated in Table 1. No magnesium metal was used in Examples 3 to 13. The test parameters and results are summarised in Table 2. The identity and purity of the isolated products were confirmed by GC/MS investigations and ^H-NMR measurements. Patent Claims A process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, characterised In that an alkali metal or mixtures or alloys of alkali metals, a Grignard compound of the general formula RMgX or a plurality of Grignard compounds of the general formulae R'MgX, R1MgX and R1MgX, an organic halide of the general formula RX or a plurality of organic halides of the general formulae R1X, R1X and R1X are reacted together, wherein: - R, R\ R1 and R1, which may be identical or different, can be chosen from H, saturated, unsaturated, branched, unbranched, functionalized, unfunctionalised, aliphatic, cyclic, heterocyclic or aromatic organic fragments, preferably fragments having from 1 to 80, particularly preferably from 1 to 40, very particularly preferably from 1 to 20 carbon atoms, and - X is chosen from chlorine, bromine, iodine, tosylate and trifoliate, preferably from chlorine, bromine and iodine. A process according to claim 1 or 2, characterised in that R, R\ R1 and R1, which may be identical or different, can be chosen from methyl, ethyl, cyclopropyl, cyclopentyl, cyclohexyl, phenyl, benzyl and heteroaryl fragments as well as branched and unbranched propel, butyl, panty, hexyls, hefty, octyl fragments. A process according to claim 1 or 2, characterised in that magnesium is additionally added. A process according to at least one of claims 1 to 3, characterised in that the alkali metal is lithium or mixtures or alloys consisting of lithium and another alkali metal, preferably sodium, wherein the amount of lithium in the mixtures or alloys is from 50 to 99.99 wt.%, preferably from 80 to 99.99 wt.%, more preferably from 90 to 99.99 wt.%. A process according to at least one of claims 1 to 4, characterised in that the molar ratio of the total amount of alkali metal to the total amount of compounds of the general formulae RX, R'X, R1X and R1X is 2n/(n+m), the molar ratio of magnesium to the total amount of compounds of the general formulae RX, R1X, R1X and R1X is m/(n+m), and the molar ratio of the total amount of compounds of the general formulae RMgX, R1MgX, R1MgX and R1MgX to the total amount of compounds of the general formulae RX, R'X, R1X and R1X Is (p-m)/(n+m), wherein n is chosen between n = 0.1 and n = 5, preferably between n = 0.8 and n = 3, and m is chosen between m = 0 and m = 5, preferably between m = 0 and m = 3, and (p-m) > 0 and p is chosen between p = 0 and p = 10, preferably between p = 0 and p = 6. A process according to at least one of claims 1 to 5, characterised in that n is chosen between n = 0.8 and n = 1.8, preferably between n = 0.8 and n = 1.2, and m is chosen between m = 0 and m = 1, preferably between m = 0 and m = 0.5, and (p-m) > 0 and p is chosen between p = 0 and p = 3, preferably between p = 0 and p = 1.5. A process according to at least one of claims 1 to 5, characterised in that for n 1 m preferably p 1 n and for n 1 m preferably p 1 m. A process according to at least one of claims 1 to 5, characterised in that n > m and p A process according to at least one of claims 1 to 8, characterised in that for the preparation of identically substituted diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts there are used a Grignard compound RMgX and an organic halide RX. A process according to at least one of claims 1 to 8, characterised in that for the preparation of differently substituted diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts there are used X . R1MgX and y. R1MgX Grignard compounds and organic halide z. R1X, wherein x and y are chosen independently of one another between 0 and (p-m) and wherein the sum of x+y = (p-m) and wherein z is chosen between 0 and (n+m) and wherein R1 = R1 ?i R1 or R1 = R1 91 R1 or R1 = R1 ?1 R1 or R1 T1 R11 R1 A process according to at least one of claims 1 to 8, characterised in that for the preparation of differently substituted diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts there are used X . R1X and y • R1X organic halides and Grignard compound z . R1MgX, wherein x and y are chosen independently of one another between 0 and (n+nn) and wherein the sum of x+y = (n+m) and wherein z is chosen between 0 and (p-m) and wherein R1 = R1 91 R1 or R1 = R1 T' R1 or R1 = R1 1 R1 or R1 ¥1 R11 Rl A process according to at least one of claims 1 to 11, characterised in that the ratio of the rate of addition of the total amount of organic halides RX, R1X, R1X, R1X to the rate of addition of the total amount of Grignard compounds RMgX, R1MgX, R1MgX, R1MgX is chosen between 1:50 and 50:1, preferably between 1:20 and 20:1, particularly preferably between 1:10 and 10:1, very particularly preferably between 1:5 and 5:1. A process according to at least one of claims 1 to 12, characterised in that the lithium or the lithium-containing alloys or mixtures are used in the form of a metal powder, a metal dispersion or metal granules, preferably in the form of a metal powder or a metal dispersion. A process according to at least one of claims 1 to 13, characterised in that the magnesium is preferably used in the form of turnings, flakes or powders. A process according to at least one of claims 1 to 14, characterised in that the Grignard compounds RMgX or R1MgX, R1MgX and/or R1MgX and the organic halides RX or R'X, R1X and/or R1X are added to a suspension of the alkali metal or of the alkali metal and magnesium. A process according to at least one of claims 1 to 15, characterised in that the reaction takes place in solvent mixtures of ethers and hydrocarbons, wherein one or more different Grignard compounds RMgX or R1MgX, R1MgX and/or R1MgX in ethers, preferably in mixtures of ethers and hydrocarbons, are used and the alkali metal or the alkali metal and magnesium is/are preferably suspended in an aromatic or aliphatic hydrocarbon. A process according to at least one of claims 1 to 16, characterised in that the reaction takes place solely in ethers, wherein there are used for the preparation one or more different Grignard compounds RMgX or R'MgX, R1MgX and/or R1MgX in ethers, and the alkali metal or the alkali metal and magnesium is/are suspended in ethers. A process according to at least one of claims 1 to 17, characterised in that there are used as ethers dimethyl ether, diethyl ether, dibutyl ether, methyl tart-butyl ether, cyclopentyl methyl ether, tetrahydrofuran or 2-methyltetrahydrofuran, preferably THF and/or 2-methyl-THF. A process according to at least one of claims 1 to 18, characterised in that there are used as hydrocarbons aprotic organic solvents, preferably toluene, cumene, xylenes, pentane, hexane, heptane, octane, cyclohexane or methylcyclohexane. A process according to at least one of claims 1 to 19, characterised in that it is carried out at temperatures of from -100°C to the boiling point of the reaction suspension, preferably at temperatures of from -15°C to the boiling point of the reaction suspension, particularly preferably from 0°C to 60°C. A synthesis agent which comprises a diorganomagnesium compound Rx1Ry1Mg in the form of a solution in an ether-containing solvent and which can be prepared according to at least one of claims 1 to 20, characterised in that the diorganomagnesium compound is in admixture with lithium halides and/or Grignard compounds RMgX and/or alkali-metal organyls RM and the molar ratio of diorganomagnesium compounds to lithium halide is from 1:0.1 to 1:2 and the molar mixing ratio of diorganomagnesium compound with Grignard compound or alkali-metal organdy is from 1:0.15 to 1:4 and the sum of X + y = 2 and x and y are chosen independently of one another from the range between 0 and 2. A synthesis agent according to claim 21, characterised in that: - the lithium halides are chosen from the group lithium chloride, lithium bromide and lithium iodide; - the solvent is chosen from dimethyl ether, diethyl ether, dibutyl ether, methyl tort-butyl ether, cyclopentyl methyl ether, tetrahydrofuran, 2-methyltetrahydrofuran, toluene, cumene, xylenes, pentane, hexane, heptane, octane, cyclohexane and methylcyclohexane or any desired mixtures of at least two of these substances, and R, R1 and R1 are chosen independently of one another from: methyl, ethyl, isopropyl, n-propyl, n-butyl, isobutyl, sec-butyl, tart-butyl, n-pentyl, n-hexyl, n-heptyl, n-octyl, cyclopropyl, cyclopentyl, cyclohexyl, phenyl, benzyl. A synthesis agent according to claim 21 or 22, characterised in that the solvent contains tetrahydrofuran and/or 2-methyltetrahydrofuran or consists of tetrahydrofuran or 2-methyltetrahydrofuran or any desired mixtures thereof. A synthesis agent according to at least one of claims 21 to 23, characterised in that the diorganomagnesium compound is a dialkyi-, dialkenyl-, dialkynyl-, diary!-, diheteroaryl-, alkylalkenyl-, alkylalkynyl-, alkylaryl-, alkylheteroaryl-, alkenylalkynyl-, alkenylaryl-, alkenylheteroaryl-, alkynylaryl- or alkynylheteroaryl-magnesium compound, preferably a di-n-alkyi-, di-sec-alkyi-, di-iso-alkyi-, di-tert-alkyi-, di-cycloalkyi-, di-aryl- and di-heteroaryl-magnesium compound, particularly preferably diethylmagnesium, di-isopropylmagnesium, di-n-propylmagnesium, di-n-butylmagnesium, di-sec-butylmagnesium, di-isobutylmagnesium, di-tert-butylmagnesium, di-cyclo-propylmagnesium, di-cyclopentyl-magnesium, di-cyclo-hexyimagnesium, di-n-pentylmagnesium, di-n-hexylmagnesium, diphenylmagnesium, dibenzylmagnesium, n-butyl-n-octylmagnesium, n-butyl-ethylmagnesium, s-butyl-ethylmagnesium or s-butyl-n-butylmagnesium. Use of the synthesis agent according to at least one of claims 21 to 24 in synthetic chemistry, preferably in organic chemistry and organometallic chemistry. Use according to claim 25, characterised in that the synthesis agent is used in halogen/metal exchange reactions, in metallation reactions, preferably in ortho-metallation reactions, in transmetallation reactions, in the preparation of organozinc halides or diorganozinc compounds, magnesium alcoholates or magnesium halides. 1

Full Text

Process for the preparation of diorganomagnesium-containing
synthesis agents
The present invention provides a diorganomagnesium-containing synthesis agent, a process for its preparation, and the use of this synthesis agent.
The present invention provides in particular a process for the preparation of mixtures of diorganomagnesium-containing synthesis agents with alkali salts for use in organic and organometallic synthetic chemistry, for example in halogen/metal exchange reactions or transmetallation reactions, or in metallation reactions.
Organomagnesium compounds are used in a variety of applications in chemical synthesis (H. G. Richey, Jr., Grignard Reagents New Developments, John Wiley and Sons, 2000; G. S. Silvermann, P. E. Rakita, Handbook of Grignard Reagents, Marcel Dekker Inc., 1996). In terms of reactivity, Grignard reagents RMgX and diorganomagnesium compounds R1R2Mg are very similar (K. Nutzel, Methoden der organischen Chemie, Metallorganische Verbindungen (Houben-Weyl, Ed.: E. Muller, O. Bayer), Thieme Verlag Stuttgart, 1973, Volume Xlll/2a, Edition 4, p. 197ff.). Mixtures of diorganomagnesium compounds with alkali-metal organyls in some cases exhibit higher reactivity, which is readily made use of in synthetic chemistry (K. Kitigawa, A. Inoue, H. Shinokubo, K. Oshima, Angew. Chem. 2000, 112, 2594; A. Inoue, K. Kitagawa, H. Shinokubo, K. Oshima, J. Org. Chem. 2001, 66, 4333; A. Inoue, K. Kitagawa, H. Shinokubo, K. Oshima, Tetrahedron 2000, 56, 9601).
Accordingly, inter alia, mixtures of Grignard or dialkylmagnesium compounds and lithium chloride LiCI are disclosed as a highly potent reagent for halogen/metal exchange reactions. By reaction of these mixtures with, for example, aryl halides, new organomagnesium compounds are obtainable which cannot be prepared, or can be prepared only with difficulty, by other processes (P. Knochel et al., EP-A-04008081; P. Knochel et al., EP-A-1582524; P. Knochel et al., Angew. Chem. Int. Ed. 2003, 42, 4302; A. Krasovskiy et al., Angew. Chem. Int. Ed. 2004, 43, 3333; P. Knochel et al., Chem. Commun. 2004, 2288; P. Knochel et al.. Org. Lett. 2004, 6, 4215; P. Knochel, Chem. Commun. 2005, 543; P. Knochel, Angew.

Chem. Int. Ed. 2005, 44, 1654; P. Knochel et al., Angew. Chem. Int. Ed. 2005, 44, 3133).
The advantage of using such dialkylmagnesium/LiCI mixtures in halogen/metal exchange reactions instead of mixtures of alkylmagnesium halides and lithium chloride is that the rate of conversion is markedly higher, unactivated organic compounds can be converted and, in addition, only half the amount of dialkylmagnesium compound need be used, because both alkyl substituents are involved in the exchange reaction. The economy of a halogen/metal exchange reaction can therefore be increased considerably by using dialkylmagnesium/LiCI mixtures. However, the use of this method requires a diorganomagnesium compound to be available and to be mixed with a lithium salt.
However, the preparation of diorganomagnesium-containing synthesis agents, on the one hand, and the mixing thereof with alkali salts, on the other hand, is complex according to the prior art.
The known methods for the preparation of diorganomagnesium-containing synthesis agents are described hereinbelow.
The transmetallation of diorganomercury compounds with magnesium yields diorganomagnesium compounds, as shown in Figure 1. However, a diorganomercury compound must be prepared and made available for this process, i Such mercury compounds are additionally extremely toxic (H. C. Holtkamp et al., J. Organomet. Chem. 1969, 19, 279).
Figure 1: Transmetallation reaction for the preparation of R2Mg compounds:

The reaction of organolithium compounds with organomagnesium halides yields diorganomagnesium compounds, with the formation of lithium halides, as shown in i Figure 2 (C. W. Kamienski et al., J. Organomet. Chem. 1967, 8, 542). By using an excess of organolithium compounds or Grignard compounds, mixtures of diorgano¬magnesium compounds and lithium organyls or Grignard compounds are formed.

This method requires that a corresponding organolithium compound be available. However, many organolithium compounds are either not obtainable or have only limited stability in aprotic organic solvents or in ether-containing aprotic organic solvent mixtures. By the use of the above-described process, diorganomagnesium-containing synthesis agents are in most cases obtained in ether-containing solvent mixtures, which can impair the selectivity of a reaction in further reactions or can also impair the reactivity of the diorganomagnesium-containing synthesis agent. In some cases, depending on the coordination strength, the ether can be removed completely by distillation by addition of higher boiling hydrocarbons. This is possible, for example, in the preparation of dibutyl-(2)-magnesium. However, hydrocarbon has to be added continuously during the distillation. The preparation of diorganomagnesium compounds in only one solvent accordingly consumes a large amount of solvent and is therefore uneconomical.
Mixtures of, for example, di-(2)-butylmagnesium with lithium chloride for use in halogen/metal exchange reactions cannot be prepared directly by reaction of 2-butylmagnesium chloride with 2-butyllithium when commercially available dilute solutions of 2-butyllithium (12% in cyclohexane) and of 2-butylmagnesium chloride (25% in tetrahydrofuran (THF)) are used, because the lithium chloride that forms
precipitates in the cyclohexane-rich solvent mixture and is accordingly no longer available for accelerating exchange reactions. If THF, for example, is added to this suspension, the lithium chloride that forms goes into solution, but the di-(2)-butylmagnesium/LiCI mixtures that are obtained are so dilute that their use in exchange reactions is uneconomical. Although a more concentrated solution of 2-
) butyllithium in, for example, cyclohexane can be used in order to obtain the desired di-(2)-butylmagnesium/LiCI mixtures directly, such concentrates are pyrophoric, have only limited stability and are difficult to handle. In addition, ether cleavage is

observed in the presence of ethers even at lower temperatures, which leads to undesirable secondary products and losses in yield.
As is shown in Figure 3, organomagnesium halides are present in solution according to W. Schlenk in the following equilibrium (W. Schlenk et al, Berichte 1929, 62, 920; W. Schlenk, Berichte 1931, 64, 734):

By the addition of specific solvents, such as, for example, pyridine. Crown ether, dioxan, tetramethylethylenediamine (TMEDA) or dimethyl ether (DME), the equilibrium is displaced in the direction towards the diorganomagnesium compound. After separation of the resulting poorly soluble magnesium halide, it is accordingly possible to obtain diorganomagnesium compounds or mixtures thereof with Grignard compounds, as is shown in Figure 4.

However, it is known that the displacement of the equilibrium is greatly dependent on the choice of solvent, the temperature, the time of action of the solvent on the Grignard compound, and the concentration of the solution. Almost complete precipitation of the magnesium halide is possible only with difficulty. It is therefore technically demanding to obtain definite products in a reproducible manner. In addition, this process requires the use of exotic solvents which are used only rarely commercially and some of which are toxic or carcinogenic.

Diorganomagnesium compounds can also be prepared by reaction of magnesium hydride MgHa with alkenes containing activated double bonds, as is shown in Figure 5:

The yields of diorganomagnesium compounds prepared by this method are low. In addition, this process requires high pressures and temperatures. As a result, secondary reactions take place and the crude product must be purified in a technically complex manner.
A further method is described in EP-B-0285374. Mixtures of lithium organyls and diorganomagnesium compounds are obtained by reaction of an alkyl halide with a mixture of, for example, lithium and magnesium in hydrocarbons containing from 0.05 to 2 molar equivalents of a Lewis base per mol of organometallic composition, as is shown in Figure 6:

This process has the disadvantage that it is carried out in mixtures of hydrocarbons and Lewis bases, for example THF. The product is therefore present in a solvent mixture. This often has a disadvantageous effect in synthetic chemistry because, for example, changed selectivities or reactivities are obtained. In addition, it is I known that if the amount of Lewis base exceeds or falls short of a specified amount, poorer yields are obtained, for example owing to secondary reactions such

as ether cleavage. Because of the higher reactivity of lithium in comparison with magnesium, an organolithium compound mainly accumulates in the reaction mixture at the beginning of the reaction. It is known, however, that many organolithium compounds, such as, for example, sec-butyllithium, have only limited stability in solvents containing Lewis bases and react with the Lewis base. Undesirable secondary products thereby form, and the yield falls accordingly. The process therefore has only limited usability. In addition, because of the poor solubility of lithium salts in solvents containing only small amounts of Lewis base, only synthesis agents that are low in or free of lithium salts are obtained according to this process, and such synthesis agents are not suitable for use in halogen/metal exchange reactions, for example.
A further process is disclosed in US-A-5171467. Here too, the reaction takes place in solvent mixtures of hydrocarbons and ethers. The process is explained by way of example by means of Figure 7.
Figure 7: Preparation of diorganomagnesium compounds via magnesium halides:

As is shown, an organolithium compound is formed as an intermediate in the synthesis and is subsequently reacted with magnesium chloride. Anhydrous magnesium chloride must therefore be used in the synthesis in order to prevent partial hydrolysis of the organolithium compound, which would lead to a loss in yield. Anhydrous magnesium chloride must be prepared in situ in a technically complex manner or must be dried at high temperatures for a long time. Both operations have a disadvantageous effect on the economy of this method. In addition, a pure diorganomagnesium compound can be obtained only when an excess of dry magnesium halide is used. If magnesium halides are used in less than stoichiometric amounts, a mixture of a diorganomagnesium compound and a lithium organyl is formed.
As has already been described above, it is known that many lithium organyls have only limited stability in ether-containing solvent mixtures because of ether cleavage.

Secondary reactions occur, which result in undesirable secondary products and poorer yields. The process therefore has only limited usability. Magnesium chloride is only sparingly soluble in mixtures of hydrocarbons and ethers, which results in a slower reaction of the organolithium compound with magnesium chloride. Long reaction times are necessary, which favours secondary reactions, for example ether cleavage. In addition, only diorganomagnesium-containing synthesis agents that are low in or free of lithium salts are obtained according to this process, which synthesis agents have only limited usability, as has been described.
In addition to these methods there are further methods, but these are suitable only for the synthesis of specific organomagnesium compounds. The direct preparation of organomagnesium compounds from magnesium and organic halides is possible only in rare cases. For example, it is possible in the case of di-(2)-butylmagnesium, butylethylmagnesium, butyloctylmagnesium, n-butyl-sec-butylmagnesium. However, these compounds can be prepared only under conditions which are very disadvantageous in terms of energy. For example, some of the alkyl halides used for the synthesis must be added under high pressure to the boiling suspension of solvent and very fine magnesium powder. Because secondary reactions also take place at the very high reaction temperatures, gaseous alkenes from p-H elimination
reactions are always given off into the surroundings. For example, it is known that relatively large amounts of butene are formed in the synthesis of dibutylmagnesium. It is also known that some of the dialkylmagnesium compounds prepared in this manner have poor solubility in the solvent used. Therefore, octyl chloride must always be added where possible to form octyl-containing
dialkylmagnesium compounds. Although the solubility of the compound is thereby increased, it is not possible to prepare a definite product in this manner. It is likewise known that solutions of the dialkylmagnesium compounds so prepared always have a very high viscosity, through the formation of coordination polymers, so that auxiliary agents such as aluminium alkyls must in principle be added in
order to lower the viscosity. However, this impairs the purity considerably. In addition, long reaction times are necessary owing to the slow oxidative addition, shown in Figure 8, of the two necessary equivalents of alkyl halide to magnesium (Magnesium Alkyls from Akzo Nobel, 1999: Metal Alkyls from Akzo Nobel, 2003; M. de Vries, Stamicarbon N. V. 1969, US-A-3737393; Zn-Zusatze: G. W. Knight, L.
5 Jackson, D. E. Mach, Dow Chemical Comp. 1975, US-A- 4213880; SiOR4-Zusatz: Akzo Nobel 1997, WO-A-99/09035; GaR3, lnR3, RLi: L. W. Fannin, D. B. Malpass,

R. Sanchez; Texas Alkyls 1980, US-A-4299781; C. W. Kamiensky, B. J. McElroy, R. O. Bach, Lithium Corp. of America 1976 US-A-4069267; L. W. Fannin, D. B. Malpass, Texas Alkyls 1977, US-A-4127507; D. B. Malpass, D. W. Webb, Texas Alkyls 1984, US-A-4547477).
Figure 8: Synthesis of R2Mg compounds from magnesium and organic halides
using the example of di-(2)-butylmagnesium:

Mixtures of diorganomagnesium compounds and alkali-metal organyls are obtained according to Figure 9 by reaction of diorganomagnesium compounds with alkali metals (D. B. Malpass, J. F. Eastham, J. Org. Chem. 1973,21,3718).
I Figure 9: Mixtures of diorganomagnesium compounds and alkali-metal
organyls:
3 R2Mg + 2 M *► 2 RsMgM + Mg 12 R2Mg + 2 RM
5 (sec-Bu)2Mg + 6 Li *- 2 (sec-Bu)5MgLi3 + 3 Mg 12 (sec-Bu)2Mg + 6 sec-BuLi
R = organic fragment, M = alkali metal
However, this process requires that a diorganomagnesium compound be available. As has been shown, however, the preparation of such compounds by methods of the prior art is difficult.
5 The speed of halogen/metal exchange reactions can be increased drastically by the use of, for example, mixtures of Grignard compounds or diorganomagnesium compounds with lithium salts. By the addition of lithium salts to the above-described compounds It is possible to prepare reagents which cannot be prepared commercially, or which can be prepared commercially only with difficulty, by other
3 processes owing to secondary reactions or long reaction times. In all the above-described possible methods of preparing diorganomagnesium compounds that do not use lithium organyls or lithium metal as starting material, a lithium salt, for

example lithium chloride, must therefore be added in a further process step. Because of the poor solubility of the lithium salt in the solvent or solvent mixture used, a solvent exchange must additionally be carried out in some cases.
If organomagnesium compounds are prepared via lithium organyls or using lithium metal, a lithium salt forms in situ. However, because it is necessary in the described processes to work in hydrocarbons or in ether/hydrocarbon mixtures owing to the implementability of the methods, the lack of stability or lack of solubility of the resulting lithium organyl, a large part of the lithium salt that forms precipitates. Although this can be brought into solution again by the addition of polar solvents, dilute solutions form, which are uneconomical to use in synthetic chemistry. In order nevertheless to obtain lithium-salt-containing mixtures, a solvent exchange is necessary in this case too in a further process step. In addition, the availability and stability of an organolithium compound are required in some cases.
Lithium chloride is very hygroscopic, which makes its subsequent introduction into organomagnesium compounds difficult. If water-containing or slightly moist lithium chloride is used, partial hydrolysis of the organomagnesium compounds takes place. Undesirable secondary products form as a result, and the yield of organomagnesium compounds falls accordingly.
All the mentioned processes for the preparation of diorganomagnesium-containing synthesis agents or mixtures thereof with alkali-metal salts are either expensive, require the handling of pyrophoric or even toxic compounds, use as starting materials organometalllc compounds which in some cases are not available commercially or organometalllc compounds which have only limited stability,
require a plurality of process steps, lead to the formation of undesirable secondary products or have only limited usability. The object of providing an efficient, simple and inexpensive process, which can be carried out commercially, for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali salts has accordingly not hitherto been achieved.
) The object of the present invention is, therefore, to provide a process for the preparation of diorganomagnesium-containing synthesis agents which overcomes the disadvantages of the prior art.

It is a particular object of the present invention to provide a process which yields identically or differently substituted diorganomagnesium-containing synthesis agents in only one specified solvent or in specified solvent mixtures, and which yields directly alkali-salt-containing solutions, but also solutions which are low in or free of alkali-metal salts, of diorganomagnesium-containing synthesis agents in specific solvents or solvent mixtures.
Surprisingly, the object is achieved according to the invention by the features of the main claim. Preferred embodiments will be found in the subsidiary claims.
Surprisingly, the process according to the invention permits the preparation of a large number of diorganomagnesium compounds, such as, for example, dialkyi-, dialkenyl-, dialkynyl-, diaryl-, diheteroaryl-, alkylalkenyl-, alkylalkynyl-, alkylaryl-, alkylheteroaryl-, alkenylalkynyl-, alkenylaryl-, alkenylheteroaryl-, alkynylaryl- or alkynylheteroaryl-magnesium compounds, or mixtures thereof with alkali-metal organyls or Grignard compounds, or mixtures with alkali-metal salts, in only one specific solvent or in specific solvent mixtures.
By means of the process according to the invention, alkali-salt-containing solutions of diorganomagnesium-containing synthesis agents or solutions that are low in or free of alkali-metal salts can also be prepared directly. The diorganomagnesium-containing synthesis agents prepared according to the invention, or mixtures
thereof with alkali-metal salts, can be used in the preparation of a large number of in some cases highly functionalised substances, such as pharmaceuticals, natural substance derivatives, polymer materials, agrochemicals, speciality chemicals and catalysts, for example in halogen/metal exchange reactions or metallation reactions, for example ortho-metallation reactions, or transmetallation reactions, for
example in the preparation of diorganozinc compounds or organozinc halides.
It has been found, surprisingly, that the desired diorganomagnesium-containing synthesis agents, or mixtures thereof with alkali-metal salts, are formed directly by reaction of a compound of the general formula RMgX - or of a plurality of compounds of the general formula R'MgX, R2MgX and R3MgX - and a compound the general formula RX - or a plurality of compounds of the general formula R1X, R2X and R3X - with alkali metal or with a mixture of alkali metal and magnesium. This embodiment of the process according to the invention is explained by the general reaction formula in Figure 10, without limiting the invention thereto.

Alkali metal within the scope of the invention is the pure alkali metal and also mixtures or alloys thereof with other alkali metals. Lithium or mixtures or alloys of lithium and another alkali metal, preferably sodium, are preferably used as the alkali metal. The content of lithium in the mixtures or alloys is from 50 to 99.99 wt.%, preferably from 80 to 99.99 wt.%, more preferably from 90 to 99.99 wt.%. However, other alkali metals can also be used.
The process according to the invention is explained in detail using the example of the following formula (Figure 10):
2n M + (n+m) RX + m Mg + (p-m) RMgX *► n R2Mg + n MX
R = organic fragment, X = halogen; M = lithium or lithium-containing
mixture or alloy
RMgX = Grignard compound or mixture of x • R1MgX and y • R1MgX
Grignard compounds , wherein x + y = (p - m) and x and y are chosen
independently of one another between 0 and (p - m)
RX = organic halide or mixture of x • R1X and y • R2X organic halides,
wherein x + y = (n+m) and x and y are chosen independently of one
another between 0 and (n+m)
The process according to the invention is generally carried out as follows:
I The alkali metal or a mixture of alkali metal and magnesium is suspended in an aprotic organic solvent or solvent mixture. The desired diorganomagnesium-containing synthesis agent or a mixture thereof with alkali-metal salts is formed by addition of a Grignard compound RMgX - or of a plurality of Grignard compounds R'MgX, R1MgX and R1MgX - and of a compound of the general formula RX - or of
i a plurality of compounds of the general formula R1X, R2X and R3X - separately or mixed beforehand. The compounds of the general formulae R'MgX, R1MgX and R1MgX are preferably added in solution in an aprotic organic solvent or solvent mixture, more preferably in the solvent or solvent mixture in which the alkali metal or the mixture of alkali metal and magnesium is suspended.
) The molar ratio of the total amount of alkali metal to the total amount of compounds of the general formulae RX, R'X, R1X and R1X is 2n/(n+m), the molar ratio of magnesium to the total amount of compounds of the general formulae RX, R1X,

R1X and R1X is m/(n+m) and the molar ratio of the total amount of compounds of the general formula RMgX, R1MgX, R1MgX and R1MgX to the total amount of compounds of the general formulae RX, R1X, R1X and R1X is (p-m)/(n+m), wherein n is chosen between n = 0.1 and n = 5, preferably between n = 0.8 and n = 3, and m is chosen between m = 0 and m = 5, preferably between m = 0 and m = 3, and wherein (p-m) > 0 and p is chosen between p = 0 and p = 10, preferably between p = 0 and p = 6.
In a preferred embodiment according to the invention for the preparation of diorganomagnesium compounds and mixtures thereof with alkali-metal salts, n is chosen between n = 0.8 and n = 1.8, preferably between n = 0.8 and n = 1.2, and m is chosen between m = 0 and m = 1, preferably between m = 0 and m = 0.5, and p is chosen between p = 0 and p = 3, preferably between p = 0 and p = 1.5, wherein (p-m) > 0.
In a preferred embodiment according to the invention for the preparation of mixtures of diorganomagnesium compounds and Grignard compounds and mixtures thereof with alkali-metal salts, p for n > m is preferably p > n and for n m.
In a preferred embodiment according to the invention for the preparation of mixtures of diorganomagnesium compounds and alkali-metal organyls and mixtures thereof with alkali-metal salts, preferably n > m and p In a preferred embodiment according to the invention for the preparation of identically substituted diorganomagnesium-containing synthesis agents, a Grignard compound RMgX and an organic halide RX are used.
In a preferred embodiment according to the invention for the preparation of differently substituted diorganomagnesium-containing synthesis agents, x • R1MgX and y • R1MgX Grignard compounds and organic halide z • R1X are used, wherein x and y are chosen independently of one another between 0 and (p-m) and wherein the sum of x+y = (p-m) and wherein z is chosen between 0 and (n+m).
In a further preferred embodiment according to the invention for the preparation of differently substituted diorganomagnesium-containing synthesis agents, x • R1X and y • R1X organic halides and Grignard compound x • R1MgX are used, wherein

X and y are chosen independently of one another between 0 and (n+m) and wherein the sum of x+y = (n+m) and wherein z is chosen between 0 and (p-m).
in a further preferred embodiment according to the invention, the ratio of the molar rate of addition of the total amount of organic halides RX, R1X, R1X, R1X to the molar rate of addition of the total amount of Grignard compounds RMgX, R1MgX, R1MgX, R1MgX is from 1:50 to 50:1, preferably from 1:20 to 20:1, particularly preferably from 1:10 to 10:1, very particularly preferably from 1:5 to 5:1.
If rates of addition other than those specified above are chosen there is the possibility of secondary reactions such as, for example, ether cleavage, in particular when the organic halide is added markedly more rapidly than the Grignard compound.
Diorganomagnesium-containing synthesis agents within the scope of the invention are diorganomagnesium compounds R2Mg or Rx1Ry1Mg and mixtures thereof with z Grignard compounds RMgX or R1MgX or z alkali-metal organyls RM or R1M. The molar mixing ratio with Grignard compounds or alkali-metal organyls is determined by z, z is in the range from 0 to 10, preferably from 0 to 4. The sum of the coefficients x and y is 2, and they are within the range between 0 and 2, independently of one another. R, R\ R1 and R1 are chosen independently of one another and are as defined hereinbelow.
Depending on the solvent or solvent mixture used, mixtures of diorganomagnesium-containing synthesis agents and alkali salt halides are obtained that differ in terms of the ratio of alkali salt to organomagnesium compound.
Lithium or lithium-containing mixtures or alloys are preferably used in the form of a metal powder, a metal dispersion or metal granules, particularly preferably in the form of a metal powder or a metal dispersion.
Magnesium is preferably used in the form of turnings, flakes or powders.
Grignard compounds RMgX and organic halides RX are preferably added to a suspension of the alkali metal or of a mixture of alkali metal and magnesium in an aprotic organic solvent or solvent mixture.

For the preparation of the diorganomagnesium-containing synthesis agents according to the invention in solvent mixtures of ethers and hydrocarbons, one or more different Grignard compounds RMgX in ethers or in mixtures of ethers and hydrocarbons are used in a further embodiment. Furthermore, the alkali metal or the alkali metal and magnesium is preferably suspended in an aromatic or aliphatic hydrocarbon. The ethers used can be removed by methods of the prior art when the reaction is complete, for example by distillation under normal pressure, under reduced pressure, by vacuum distillation or by concentration by evaporation. Solutions of diorganomagnesium-containing synthesis agents that are low in or free of alkali-metal salts are thus formed.
For the preparation of diorganomagnesium-containing synthesis agents containing alkali-metal salts, for example for use in halogen/metal exchange reactions or metallation reactions, solely ethereal solvents are used in a preferred embodiment, preference being given to cyclic ethers and particularly preferably to THF and 2-methyl-THF.
The process for the preparation of diorganomagnesium-containing synthesis agents is preferably carried out with the exclusion of air and moisture, preferably in an inert gas atmosphere, particularly preferably in a nitrogen or argon atmosphere.
The process according to the invention can be carried out at temperatures from -100°C to the boiling point of the reaction suspension; it is preferably carried out in a temperature range from -15°C to the boiling point of the reaction suspension, particularly preferably from 0°C to 60°C.
The diorganomagnesium-containing synthesis agent according to the invention is obtained in addition to solids, which in a preferred embodiment are separated off by methods of the prior art. Methods of the prior art are, for example, decantation, filtration or centrifugation. The resulting solutions of diorganomagnesium-containing synthesis agents are either free of alkali-metal salt or contain alkali-metal salt, depending on the solvent or solvent mixture, and can be used directly in organic or organometallic synthetic chemistry.
In the Grignard compounds of the general composition RMgX, R1MgX, R1MgX and R1MgX and in the organic halides RX, RX, R1X and R1X and in the

diorganomagnesium compounds R2Mg and Rx3Ry3Mg and mixtures thereof with all - R, R\ R3 and R3, which may be identical or different, can be selected from H, saturated, unsaturated, branched, unbranched, functionalised, unfunctionalised, aliphatic, cyclic, heterocyclic or aromatic organic fragments, preferably fragments having from 1 to 80, particularly preferably from 1 to 40, very particularly preferably from 1 to 20 carbon atoms, and
- R can generally also represent R\ R3 and R3, and
- X is selected from chlorine, bromine, iodine, tosylate and triflate, preferably from chlorine, bromine and iodine, and
- M is an alkali metal.
In particular, R, R\ R3 and R3, which may be identical or different, can be selected from methyl, ethyl, cyclopropyl, cyclopentyl, cyclohexyl, phenyl, benzyl and heteroaryl fragments as well as branched and unbranched propyl, butyl, pentyl, hexyl, heptyl, octyl fragments.
Preferred aprotic organic solvents are aliphatic or aromatic hydrocarbons, heterocycles, ethers, amines, nitriles or mixtures thereof.
Within the scope of the invention, the term aliphatic hydrocarbons includes cyclic, saturated, unsaturated, branched and unbranched hydrocarbons. Preference is given to saturated or cyclic, branched or unbranched hydrocarbons having from 5 to 20 carbon atoms, particularly preferably n-pentane, n-hexane, n-heptane, n-octane or the isomers thereof, cyclopentane, cyclohexane and methylcyclohexane.
Within the scope of the invention, the term ethers includes acyclic, cyclic, saturated, unsaturated, branched, unbranched, identically substituted and differently substituted ethers having at least one oxygen atom, preferably having from one to four oxygen atoms. Also preferred as ethers are dimethyl ether, diethyl ether, dibutyl ether, dimethoxyethane, diethoxymethane, polyethylene glycol, methyl tert-butyl ether, cyclopentyl methyl ether, dioxan, tetrahydrofuran and 2-methyl-tetrahydrofuran, and particular preference is given to THF and 2-methyl-THF.
Within the scope of the invention, the term amines includes acyclic, cyclic, saturated, unsaturated, branched, unbranched, identically substituted and

differently substituted amines having at least one nitrogen atom, preferably having from one to four nitrogen atoms, preference being given to N,N-tetramethylethylenediamine.
Within the scope of the invention, the term aromatic hydrocarbons includes unsubstituted, monosubstituted and polysubstituted aromatic compounds. Benzene, toluene, ethylbenzene, cumene and xylene and the isomers thereof are preferably used.
Within the scope of the invention, heterocycles are substituted, unsubstituted, aromatic, saturated and unsaturated cyclic compounds which consist in the ring of at least four carbon atoms and at least one atom from the group of the heteroatoms oxygen, sulfur and nitrogen, preference being given to from four to six carbon atoms and from one to three heteroatoms, particular preference being given to pyridine, THF and 2-methyltetrahydrofuran.
In detail, the invention provides:
a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, characterised in that an alkali metal or mixtures or alloys of alkali metals, a Grignard compound of the general formula RMgX or a plurality of Grignard compounds of the general formulae R3MgX, R3MgX and R3MgX, an organic halide of the general formula RX or a plurality of organic halides of the general formulae R3X, R3X and R3X are reacted with one another;
a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts using alkali metals or mixtures or alloys of alkali metals, Grignard compounds of the general formula RMgX and organic halides of the general formula RX, wherein the diorganomagnesium-containing synthesis agents are formed directly from the added reagents;
a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein magnesium is additionally also used;
a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein alkali metal is to be understood as being lithium or mixtures or alloys consisting of lithium and

another alkali metal, preferably sodium, wherein the amount of lithium in the mixtures or alloys is from 50 to 99.99 wt.%, preferably from 80 to 99.99 wt.%, more preferably from 90 to 99.99 wt.%;
a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein the alkali metal or the alkali metal and magnesium is/are suspended in an organic aprotic solvent or solvent mixture and a compound of the general formula RMgX or a plurality of compounds of the general formulae R1MgX, R1MgX and R1MgX - separately or mixed beforehand - and a compound of the general formula RX or a plurality of compounds of the general formulae R1X, R1X and R1X - separately or mixed beforehand - are added;
a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein there are added compounds of the general formulae RMgX, R1MgX, R1MgX and R1MgX dissolved in an aprotic organic solvent or solvent mixture, preferably in the solvent or solvent mixture in which the alkali metal or the alkali metal and magnesium is/are suspended;
a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein the molar ratio of the total amount of alkali metal to the total amount of compounds of the general formulae RX, R1X, R1X and R1X is 2n/(n+m), the molar ratio of magnesium to the total amount of compounds of the general formulae RX, R'X, R1X and R1X is m/(n+m) and the molar ratio of the total amount of compounds of the general formulae RMgX, R'MgX, R1MgX and R1MgX to the total amount of compounds of the general formulae RX, R1X, R1X and R1X is (p-m)/(n+m), wherein n is chosen between n = 0.1 and n = 5, preferably between n = 0.8 and n = 3, and m is chosen between m = 0 and m = 5, preferably between m = 0 and m = 3, and (p-m) > 0 and p is chosen between p = 0 and p = 10, preferably between p = 0 and p = 6;
a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein in a preferred embodiment for the preparation of diorganomagnesium compounds and mixtures thereof with alkali-metal salts n is chosen between n = 0.8 and n = 1.8, preferably between n = 0.8 and n = 1.2, and m is chosen between m = 0 and m = 1, preferably between m = 0 and m = 0.5, and (p-m) > 0 and p is

chosen from a range between p = 0 and p = 3, preferably between p = 0 and p = 1.5;
a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein for the preparation of mixtures of diorganomagnesium compounds and Grignard compounds and mixtures thereof with alkali-metal salts for n m preferably p > n and for n a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein for the preparation of mixtures of diorganomagnesium compounds and alkali-metal organyls and mixtures thereof with alkali-metal salts n > m and p n;
a process for the preparation of identically substituted diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein a Grignard compound RMgX and an organic halide RX are used;
a process for the preparation of differently substituted diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein there are used for the preparation x • R1MgX and y . R1MgX Grignard

particularly preferably between 1:10 and 10:1, very particularly preferably between 1:5 and 5:1;
a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein the lithium or the lithium-containing alloys or mixtures are used in the form of a metal powder, a metal dispersion or metal granules, preferably in the form of a metal powder or a metal dispersion;
a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein the magnesium is preferably used in the form of turnings, flakes or powders;
a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein the Grignard compounds RMgX or R1MgX, R1MgX and/or R1MgX and the organic halides RX or R1X, R1X and/or R1X are added to a suspension of the alkali metal or of the alkali metal and magnesium;
a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts in solvent mixtures of ethers and hydrocarbons, wherein there are used for the preparation one or more different Grignard compounds RMgX or R1MgX, R1MgX and/or R1MgX in ethers or, preferably, in mixtures of ethers and hydrocarbons and wherein the alkali metal or the alkali metal and magnesium is/are preferably suspended in an aromatic or aliphatic hydrocarbon, and wherein, when the reaction is complete, the ethers used can be removed by methods of the prior art, for example by distillation under normal pressure, under reduced pressure, by vacuum distillation or by concentration by evaporation, and wherein solutions of organomagnesium compounds that are low in or free of alkali-metal salts are formed;
a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein for the preparation of diorganomagnesium-containing synthesis agents containing alkali-metal salts, for example for use in halogen/metal exchange reactions or metallation reactions, there are used solely ethereal solvents, preference being given to the use of cyclic ethers and particularly preferably THF and 2-methyl-THF;
a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein the processes are

carried out with the exclusion of air and moisture, preferably in an inert gas atmosphere, particularly preferably in a nitrogen or argon atmosphere;
a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein the process according to the invention is carried out at temperatures of from -100°C to the boiling point of the reaction suspension, preferably at temperatures of from -15°C to the boiling point of the reaction suspension, particularly preferably from 0°C to 60°C;
a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein the corresponding diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts are separated from precipitated solids by methods of the prior art, preferably decantation, filtration or centrifugation;
a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein R, R1 R1 and R1 are in all cases selected independently of one another from H, saturated, unsaturated, branched, unbranched, functionalised, unfunctionalised, aliphatic, cyclic, heterocyclic or aromatic organic fragments, wherein in particular saturated, unsaturated, branched, unbranched, functionalised, unfunctionalised, aliphatic, cyclic, heterocyclic or aromatic organic fragments having from 1 to 80 carbon atoms are preferred, wherein saturated, unsaturated, branched, unbranched, functionalised, unfunctionalised, aliphatic, cyclic, heterocyclic or aromatic organic fragments having from 1 to 40 carbon atoms are preferred, wherein saturated, unsaturated, branched, unbranched, functionalised, unfunctionalised, aliphatic, cyclic, heterocyclic or aromatic organic fragments having from 1 to 20 carbon atoms are particularly preferred, and wherein branched and unbranched methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, cyclopropyl, cyclopentyl, cyclohexyl, phenyl, benzyl and heteroaryl fragments are particularly preferred, and X is selected from chlorine, bromine, iodine, tosylate and triflate, preferably from chlorine, bromine and iodine;
a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein aprotic organic solvents are used;

a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein aliphatic or aromatic hydrocarbons, heterocycles, ethers, amines, nitriles or mixtures thereof are used;
a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein there are used as aliphatic hydrocarbons cyclic, saturated, unsaturated, branched and unbranched hydrocarbons, preferably saturated or cyclic, branched or unbranched hydrocarbons having from 5 to 20 carbon atoms, particularly preferably n-pentane, n-hexane, n-heptane, n-octane or the isomers thereof, cyclopentane, cyclohexane and methylcyclohexane;
a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein there are used as ethers cyclic, saturated, unsaturated, branched, unbranched, identically substituted and differently substituted ethers having at least one oxygen atom, preferably having from one to four oxygen atoms, particularly preferably dimethyl ether, diethyl ether, dibutyl ether, dimethoxyethane, diethoxymethane, methyl tert-butyl ether, polyethylene glycol, cyclopentyl methyl ether, dioxan, tetrahydrofuran and 2-methyltetrahydrofuran;
a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein there are used as amines cyclic, aliphatic, saturated, unsaturated, branched, unbranched, identically substituted and differently substituted amines having at least one nitrogen atom, preferably having from one to four nitrogen atoms, particular preference being given to N,N-tetramethylethylenediamine;
a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein there are used as aromatic hydrocarbons unsubstituted, monosubstituted and polysubstituted aromatic compounds, preferably benzene, toluene, ethylbenzene, cumene and/or xylenes or the isomers thereof;
a process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, wherein there are used as heterocycles substituted, unsubstituted, aromatic, saturated and unsaturated cyclic compounds which consist in the ring of at least four carbon atoms, preferably from four to six carbon atoms, and at least one atom, preferably from

one to three atoms, from the group of the heteroatoms oxygen, sulfur and nitrogen, wherein THF, 2-methyl-THF and pyridine are particularly preferred;
a process for the preparation of identically or differently substituted dialkyi-, dialkenyl-, dialkynyl-, diaryl-, diheteroaryl-, alkylalkenyl-, alkylalkynyl-, alkylaryl-, alkylheteroaryl-, alkenylalkynyl-, alkenylaryl-, alkenylheteroaryl-, alkynylaryl- or alkynylheteroaryl-magnesium compounds or mixtures thereof with alkali salts, Grignard compounds RMgX or organolithium compounds RLi;
a process for the preparation of identically or differently substituted di-n-alkyi-, di-sec-alkyi-, di-iso-alkyi-, di-tert-alkyi-, di-cycloalkyi-, di-aryl- and di-heteroaryl-magnesium compounds or mixtures thereof with alkali salts, Grignard compounds RMgX or organolithium compounds RLi;
a process for the preparation of dimethylmagnesium, diethylmagnesium, di-
isopropylmagnesium, di-n-propylmagnesium, di-n-butylmagnesium, di-sec-
butylmagnesium, di-isobutylmagnesium, di-tert-butylmagnesium, di-cyclo-
propylmagnesium, di-cyclo-pentylmagnesium, di-cyclo-hexylmagnesium, di-n-
pentylmagnesium, di-n-hexylmagnesium, diphenylmagnesium,
dibenzylmagnesium, n-butyl-n-octylmagnesium, n-butyl-ethylmagnesium, s-butyl-ethylmagnesium or s-butyl-n-butylmagnesium or mixtures thereof with alkali salts, Grignard compounds RMgX or organolithium compounds RLi;
the use of the diorganomagnesium-containing synthesis agents prepared according to the invention, and of mixtures thereof with alkali salts, in synthetic chemistry;
the use of the diorganomagnesium-containing synthesis agents prepared according to the invention, and of mixtures thereof with alkali salts, in organic chemistry and organometallic chemistry;
the use of the diorganomagnesium-containing synthesis agents prepared according to the invention, and of mixtures thereof with alkali salts, in halogen/ metal exchange reactions;
the use of the diorganomagnesium-containing synthesis agents prepared according to the invention, and of mixtures thereof with alkali salts, in metallation reactions, preferably in ortho-metallation reactions;
the use of the diorganomagnesium-containing synthesis agents prepared according to the invention, and of mixtures thereof with alkali salts, in transmetallation reactions;

the use of the diorganomagnesium-containing synthesis agents prepared according to the invention, and of mixtures thereof with alkali salts, in the preparation of organozinc halides or diorganozinc compounds;
the use of the diorganomagnesium-containing synthesis agents prepared according to the invention, and of mixtures thereof with alkali salts, in the preparation of magnesium alcoholates and magnesium halides;
a diorganomagnesium compound Rx1Ry1Mg in the form of a solution in an ether-containing solvent, wherein it is present in admixture with lithium halides and/or Grignard compounds RMgX and/or alkali-metal organyls RM and the molar ratio of diorganomagnesium compounds to lithium halide is from 1:0.1 to 1:2 and the molar mixing ratio of diorganomagnesium compound and Grignard compound or alkali-metal organyl is from 1:0.15 to 1:4 and the sum of x+y = 2 and X and y are chosen independently of one another from the range between 0 and 2;
a solution of diorganomagnesium compounds Rx1Ry1Mg and lithium halides selected from the group lithium chloride, lithium bromide and lithium iodide in a tetrahydrofuran- or 2-methyltetrahydrofuran-containing solvent, and mixtures thereof with Grignard compounds RMgX or alkali-metal organyls RM, wherein R, R1 and R1 are chosen independently of one another from secondary alkyl groups, preferably sec-butyl, isopropyl, cyclopropyl, cyclopentyl, cyclohexyl, and the molar ratio of Rx1Ry1Mg to the lithium halide is in the range from 1:0.1 to 1:2 and the molar mixing ratio of diorganomagnesium compound and Grignard compound or alkali-metal organyl is from 1:0.15 to 1:4 and the sum x+y = 2 and x and y are chosen independently of one another from the range between 0 and 2;
a solution of diorganomagnesium compounds Rx1Ry1Mg and lithium halides selected from the group lithium chloride, lithium bromide and lithium iodide in a tetrahydrofuran- or 2-methyltetrahydrofuran-containing solvent, and mixtures thereof with Grignard compounds RMgX or alkali-metal organyls RM, wherein R, R1 and R1 are chosen independently of one another from methyl, ethyl, isopropyl, n-propyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, n-octyl, cyclopropyl, cyclopentyl, cyclohexyl, phenyl, benzyl, and the molar ratio of Rx1Ry1Mg to the lithium halide is in the range from 1:0.1 to 1:2 and the molar mixing ratio of diorganomagnesium compound and Grignard compound or alkali-metal organyl is from 1:0.15 to 1:4 and the sum x+y = 2 and

X and y are chosen independently of one another from the range between 0 and 2;
a solution of diorganomagneslum compounds Rx1Ry1Mg and lithium halides selected from the group lithium chloride, lithium bromide and lithium iodide in tetrahydrofuran or 2-methyltetrahydrofuran, and mixtures thereof with Grignard compounds RMgX or alkali-metal organyls RM, wherein R, R1 and R1 are chosen independently of one another from methyl, ethyl, isopropyl, n-propyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, n-octyl, cyclopropyl, cyclopentyl, cyclohexyl, phenyl, benzyl, and the molar ratio of Rx1Ry1Mg to the lithium halide is in the range from 1:0.1 to 1:2 and the molar mixing ratio of diorganomagneslum compound and Grignard compound or alkali-metal organyl is from 1:0.15 to 1:4 and the sum x+y = 2 and x and y are chosen independently of one another from the range between 0 and 2;
a solution of diorganomagneslum compounds Rx1Ry1Mg and lithium halides selected from the group lithium chloride, lithium bromide and lithium iodide in solvent mixtures of hydrocarbons and ethers, and mixtures thereof with Grignard compounds RMgX or alkali-metal organyls RM, wherein R, R"" and R1 are chosen independently of one another from methyl, ethyl, isopropyl, n-propyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, n-octyl, cyclopropyl, cyclopentyl, cyclohexyl, phenyl, benzyl, and the molar ratio of Rx1Ry1Mg to the lithium halide is in the range from 1:0.05 to 1:2 and the molar mixing ratio of diorganomagneslum compound and Grignard compound or alkali-metal organyl is from 1:0.05 to 1:4 and the sum x+y = 2 and x and y are chosen independently of one another from the range between 0 and 2, and wherein the molar ratio of ether to diorganomagneslum compound is from 0.02:1 to 50:1;
a solution of diorganomagneslum compounds Rx1Ry1Mg and lithium halides selected from the group lithium chloride, lithium bromide and lithium iodide in solvent mixtures of dimethyl ether, diethyl ether, dibutyl ether, methyl tert-butyl ether, cyclopentyl methyl ether, tetrahydrofuran or 2-methyltetrahydrofuran and toluene, cumene, xylenes, pentane, hexane, heptane, octane, cyclohexane or methylcyclohexane, and mixtures thereof with Grignard compounds RMgX or alkali-metal organyls RM, wherein R, R1 and R1 are chosen independently of one another from methyl, ethyl, isopropyl, n-propyl, n-butyl, isobutyl sec-butyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, n-octyl, cyclopropyl, cyclopentyl, cyclohexyl, phenyl, benzyl, and the molar ratio of Rx1Ry1Mg to the lithium halide

is in the range from 1:0.05 to 1:2 and the molar mixing ratio of diorganomagnesium compound and Grignard compound or -metal organyl is from 1:0.05 to 1:4 and the sum x+y = 2 and x and y are chosen independently of one another from the range between 0 and 2, and wherein the molar ratio of ether to diorganomagnesium compound is from 0.02:1 to 50:1.
The invention Is explained by means of the following examples, without being limited thereto.
To illustrate the efficiency of the process according to the invention, the preparation of di-sec-butylmagnesium and mixtures thereof with sec-BuLi or sec-BuMgCI and LiCI is chosen. The preparation of this compound according to the prior art, for example by oxidative addition of two equivalents of sec-butyl chloride to magnesium, leads, as has been described, to p-H elimination and various secondary products. In addition, high process temperatures and long reaction times are necessary. Tests for the preparation of {sec-Bu)2Mg by transmetallation with sec-BuLi result in solvent mixtures. If lithium-chloride-containing solutions are to be obtained directly by reaction of sec-BuMgCI with sec-BuLi, it is necessary to work with sec-BuLi concentrate, which has only limited stability and is also pyrophoric. If the synthesis of sec-Bu2Mg/LiCI mixtures with sec-BuMgCI and sec-BuLi concentrate is carried out in THF at 0°C, for example, THF cleavage is additionally observed, so that the product solution is contaminated.
All tests are carried out in an argon atmosphere using Schlenk techniques. Commercial raw materials were used. With regard to sec-BuMgCI, various batches in the form of approximately 25% solutions in THF are used. The precise content and the composition of the batches are determined by wet analysis. With regard to lithium, lithium metal having different sodium contents was used. The sodium content is shown in Fig. 1, Table 1.
The test parameters, analytical results and evaluations of the examples relating to the preparation according to the invention of organomagnesium compounds are summarised in Figs. 1 and 2, Tables 1 and 2. In the examples, R = sec-butyl.
Where indicated, samples were taken during the reaction and examined by wet analysis. This was not taken into account when determining the yield, so that

where samples were taken, the yields indicated in the tables are lower according to the number of samples.
The magnesium content was determined by complexometry, the chloride content by argentometry and the total base content by acidimetry after hydrolysis. The active base was determined according to Watson-Eastham using 2,2'-biquinoline as indicator.
Examples 1 to 13: Diorganomagnesium-containing synthesis agents via lithium, sec-butyl chloride and sec-butylmagnesium chloride, in some cases with magnesium, according to Figure 10:
General procedure described by means of Example 1:
24.0 g (259 mmol) of sec-butyl chloride and 81.0 g (166 mmol) of sec-butylmagnesium chloride (in the form of an approximately 25% solution in THF) are added in the course of 125 minutes, at a reaction temperature of 25°C, to a suspension of 3.00 g (432 mmol) of lithium metal and 1.73 g (71 mmol) of coarse magnesium powder in 149 g of THF. After a post-reaction time of 60 minutes at 25°C, the resulting suspension is filtered and the residue is washed with THF and then dried in vacuo.
Yield original solution: 221.4 g of a brown solution; washing solution: 86.44 g.
Examples 2 to 13 were carried out analogously to Example 1 according to the experimental parameters indicated in Table 1. No magnesium metal was used in Examples 3 to 13. The test parameters and results are summarised in Table 2.
The identity and purity of the isolated products were confirmed by GC/MS investigations and ^H-NMR measurements.

Patent Claims
A process for the preparation of diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts, characterised In that an alkali metal or mixtures or alloys of alkali metals, a Grignard compound of the general formula RMgX or a plurality of Grignard compounds of the general formulae R'MgX, R1MgX and R1MgX, an organic halide of the general formula RX or a plurality of organic halides of the general formulae R1X, R1X and R1X are reacted together, wherein:
- R, R\ R1 and R1, which may be identical or different, can be chosen from H, saturated, unsaturated, branched, unbranched, functionalized, unfunctionalised, aliphatic, cyclic, heterocyclic or aromatic organic fragments, preferably fragments having from 1 to 80, particularly preferably from 1 to 40, very particularly preferably from 1 to 20 carbon atoms, and
- X is chosen from chlorine, bromine, iodine, tosylate and trifoliate, preferably from chlorine, bromine and iodine.
A process according to claim 1 or 2, characterised in that R, R\ R1 and R1, which may be identical or different, can be chosen from methyl, ethyl, cyclopropyl, cyclopentyl, cyclohexyl, phenyl, benzyl and heteroaryl fragments as well as branched and unbranched propel, butyl, panty, hexyls, hefty, octyl fragments.
A process according to claim 1 or 2, characterised in that magnesium is additionally added.
A process according to at least one of claims 1 to 3, characterised in that the alkali metal is lithium or mixtures or alloys consisting of lithium and another alkali metal, preferably sodium, wherein the amount of lithium in the mixtures or alloys is from 50 to 99.99 wt.%, preferably from 80 to 99.99 wt.%, more preferably from 90 to 99.99 wt.%.
A process according to at least one of claims 1 to 4, characterised in that the molar ratio of the total amount of alkali metal to the total amount of compounds of the general formulae RX, R'X, R1X and R1X is 2n/(n+m), the molar ratio of magnesium to the total amount of compounds of the general formulae RX, R1X, R1X and R1X is m/(n+m), and the molar ratio of the total

amount of compounds of the general formulae RMgX, R1MgX, R1MgX and R1MgX to the total amount of compounds of the general formulae RX, R'X, R1X and R1X Is (p-m)/(n+m), wherein n is chosen between n = 0.1 and n = 5, preferably between n = 0.8 and n = 3, and m is chosen between m = 0 and m = 5, preferably between m = 0 and m = 3, and (p-m) > 0 and p is chosen between p = 0 and p = 10, preferably between p = 0 and p = 6.
A process according to at least one of claims 1 to 5, characterised in that n is chosen between n = 0.8 and n = 1.8, preferably between n = 0.8 and n = 1.2, and m is chosen between m = 0 and m = 1, preferably between m = 0 and m = 0.5, and (p-m) > 0 and p is chosen between p = 0 and p = 3, preferably between p = 0 and p = 1.5.
A process according to at least one of claims 1 to 5, characterised in that for n 1 m preferably p 1 n and for n 1 m preferably p 1 m.
A process according to at least one of claims 1 to 5, characterised in that n > m and p A process according to at least one of claims 1 to 8, characterised in that for the preparation of identically substituted diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts there are used a Grignard compound RMgX and an organic halide RX.
A process according to at least one of claims 1 to 8, characterised in that for the preparation of differently substituted diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts there are used X . R1MgX and y. R1MgX Grignard compounds and organic halide z. R1X, wherein x and y are chosen independently of one another between 0 and (p-m) and wherein the sum of x+y = (p-m) and wherein z is chosen between 0 and (n+m) and wherein R1 = R1 ?i R1 or R1 = R1 91 R1 or R1 = R1 ?1 R1 or R1 T1 R11 R1
A process according to at least one of claims 1 to 8, characterised in that for the preparation of differently substituted diorganomagnesium-containing synthesis agents and mixtures thereof with alkali-metal salts there are used X . R1X and y • R1X organic halides and Grignard compound z . R1MgX,

wherein x and y are chosen independently of one another between 0 and (n+nn) and wherein the sum of x+y = (n+m) and wherein z is chosen between 0 and (p-m) and wherein R1 = R1 91 R1 or R1 = R1 T' R1 or R1 = R1 1 R1 or R1 ¥1 R11 Rl
A process according to at least one of claims 1 to 11, characterised in that the ratio of the rate of addition of the total amount of organic halides RX, R1X, R1X, R1X to the rate of addition of the total amount of Grignard compounds RMgX, R1MgX, R1MgX, R1MgX is chosen between 1:50 and 50:1, preferably between 1:20 and 20:1, particularly preferably between 1:10 and 10:1, very particularly preferably between 1:5 and 5:1.
A process according to at least one of claims 1 to 12, characterised in that the lithium or the lithium-containing alloys or mixtures are used in the form of a metal powder, a metal dispersion or metal granules, preferably in the form of a metal powder or a metal dispersion.
A process according to at least one of claims 1 to 13, characterised in that the magnesium is preferably used in the form of turnings, flakes or powders.
A process according to at least one of claims 1 to 14, characterised in that the Grignard compounds RMgX or R1MgX, R1MgX and/or R1MgX and the organic halides RX or R'X, R1X and/or R1X are added to a suspension of the alkali metal or of the alkali metal and magnesium.
A process according to at least one of claims 1 to 15, characterised in that the reaction takes place in solvent mixtures of ethers and hydrocarbons, wherein one or more different Grignard compounds RMgX or R1MgX, R1MgX and/or R1MgX in ethers, preferably in mixtures of ethers and hydrocarbons, are used and the alkali metal or the alkali metal and magnesium is/are preferably suspended in an aromatic or aliphatic hydrocarbon.
A process according to at least one of claims 1 to 16, characterised in that the reaction takes place solely in ethers, wherein there are used for the preparation one or more different Grignard compounds RMgX or R'MgX, R1MgX and/or R1MgX in ethers, and the alkali metal or the alkali metal and magnesium is/are suspended in ethers.

A process according to at least one of claims 1 to 17, characterised in that there are used as ethers dimethyl ether, diethyl ether, dibutyl ether, methyl tart-butyl ether, cyclopentyl methyl ether, tetrahydrofuran or 2-methyltetrahydrofuran, preferably THF and/or 2-methyl-THF.
A process according to at least one of claims 1 to 18, characterised in that there are used as hydrocarbons aprotic organic solvents, preferably toluene, cumene, xylenes, pentane, hexane, heptane, octane, cyclohexane or methylcyclohexane.
A process according to at least one of claims 1 to 19, characterised in that it is carried out at temperatures of from -100°C to the boiling point of the reaction suspension, preferably at temperatures of from -15°C to the boiling point of the reaction suspension, particularly preferably from 0°C to 60°C.
A synthesis agent which comprises a diorganomagnesium compound Rx1Ry1Mg in the form of a solution in an ether-containing solvent and which can be prepared according to at least one of claims 1 to 20, characterised in that the diorganomagnesium compound is in admixture with lithium halides and/or Grignard compounds RMgX and/or alkali-metal organyls RM and the molar ratio of diorganomagnesium compounds to lithium halide is from 1:0.1 to 1:2 and the molar mixing ratio of diorganomagnesium compound with Grignard compound or alkali-metal organdy is from 1:0.15 to 1:4 and the sum of X + y = 2 and x and y are chosen independently of one another from the range between 0 and 2.
A synthesis agent according to claim 21, characterised in that:
- the lithium halides are chosen from the group lithium chloride, lithium bromide and lithium iodide;
- the solvent is chosen from dimethyl ether, diethyl ether, dibutyl ether, methyl tort-butyl ether, cyclopentyl methyl ether, tetrahydrofuran, 2-methyltetrahydrofuran, toluene, cumene, xylenes, pentane, hexane, heptane, octane, cyclohexane and methylcyclohexane or any desired mixtures of at least two of these substances, and

R, R1 and R1 are chosen independently of one another from: methyl, ethyl, isopropyl, n-propyl, n-butyl, isobutyl, sec-butyl, tart-butyl, n-pentyl, n-hexyl, n-heptyl, n-octyl, cyclopropyl, cyclopentyl, cyclohexyl, phenyl, benzyl.
A synthesis agent according to claim 21 or 22, characterised in that the solvent contains tetrahydrofuran and/or 2-methyltetrahydrofuran or consists of tetrahydrofuran or 2-methyltetrahydrofuran or any desired mixtures thereof.
A synthesis agent according to at least one of claims 21 to 23, characterised in that the diorganomagnesium compound is a dialkyi-, dialkenyl-, dialkynyl-, diary!-, diheteroaryl-, alkylalkenyl-, alkylalkynyl-, alkylaryl-, alkylheteroaryl-, alkenylalkynyl-, alkenylaryl-, alkenylheteroaryl-, alkynylaryl- or alkynylheteroaryl-magnesium compound, preferably a di-n-alkyi-, di-sec-alkyi-, di-iso-alkyi-, di-tert-alkyi-, di-cycloalkyi-, di-aryl- and di-heteroaryl-magnesium compound, particularly preferably diethylmagnesium, di-isopropylmagnesium, di-n-propylmagnesium, di-n-butylmagnesium, di-sec-butylmagnesium, di-isobutylmagnesium, di-tert-butylmagnesium, di-cyclo-propylmagnesium, di-cyclopentyl-magnesium, di-cyclo-hexyimagnesium, di-n-pentylmagnesium, di-n-hexylmagnesium, diphenylmagnesium, dibenzylmagnesium, n-butyl-n-octylmagnesium, n-butyl-ethylmagnesium, s-butyl-ethylmagnesium or s-butyl-n-butylmagnesium.
Use of the synthesis agent according to at least one of claims 21 to 24 in synthetic chemistry, preferably in organic chemistry and organometallic chemistry.
Use according to claim 25, characterised in that the synthesis agent is used in halogen/metal exchange reactions, in metallation reactions, preferably in ortho-metallation reactions, in transmetallation reactions, in the preparation of organozinc halides or diorganozinc compounds, magnesium alcoholates or magnesium halides.
1

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Patent Number

271021

Indian Patent Application Number

2400/CHENP/2008

PG Journal Number

06/2016

Publication Date

05-Feb-2016

Grant Date

29-Jan-2016

Date of Filing

14-May-2008

Name of Patentee

CHEMETALL GmbH

Applicant Address

TRAKEHNER STRASSE 3, D-60487 FRANKFURT

Inventors:

#	Inventor's Name	Inventor's Address
1	LANG, SEBASTIAN	KONIGSTEINERSTRASSE 57, 65929 FRANKFURT AM MAIN
2	RODER, JENS	SCHLOSSSTRASSE 37 H, 60486 FRANKFURT AM MAIN
3	MURSO, ALEXANDER	JOSEF-MAY-STRASSE 1, 60489 FRANKFURT AM MAIN
4	WIETELMANN, ULRICH	RODHEIMER STRASSE 19, D-61381 FRIEDRICHSDORF
5	LISCHKA, UWE	GUNTER-VOGT-RING 79, 60437 FRANKFURT AM MAIN

PCT International Classification Number

C07F3/02

PCT International Application Number

PCT/EP06/67464

PCT International Filing date

2006-10-16

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1	102005049635.0	2005-10-14	Germany
2	102006024915.1	2006-05-24	Germany