Title of Invention	“NOVEL HYDROPHILIC DERIVATIVES OF 2-ARYL-4-QUINOLONES AS ANTICANCER AGENTS”
Abstract	2-aryl-4-quinolones are converted into phosphates by reacting with tetrabenzyl pyrophosphate to form dibenzyl phosphates thereof, which are then subject to hydrogenation to replace dibenzyl groups with H, followed by reacting with Amberlite IR-120(Na+ form) to form disodium salts. The 5 results of preliminary screening revealed that these phosphates showed significant anti-cancer activity. A novel intermediate, 2-selenophene 4-quinolone and N, N-dialkylaminoalkyl derivatives of 2-phenyl-4-quinolones are also synthesized. These novel intermediates exhibited significant anticancer activities. 10

Title of Invention

“NOVEL HYDROPHILIC DERIVATIVES OF 2-ARYL-4-QUINOLONES AS ANTICANCER AGENTS”

Abstract

2-aryl-4-quinolones are converted into phosphates by reacting with tetrabenzyl pyrophosphate to form dibenzyl phosphates thereof, which are then subject to hydrogenation to replace dibenzyl groups with H, followed by reacting with Amberlite IR-120(Na+ form) to form disodium salts. The 5 results of preliminary screening revealed that these phosphates showed significant anti-cancer activity. A novel intermediate, 2-selenophene 4-quinolone and N, N-dialkylaminoalkyl derivatives of 2-phenyl-4-quinolones are also synthesized. These novel intermediates exhibited significant anticancer activities. 10

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Patent Number

271317

Indian Patent Application Number

3052/CHENP/2009

PG Journal Number

08/2016

Publication Date

19-Feb-2016

Grant Date

16-Feb-2016

Date of Filing

01-Jun-2009

Name of Patentee

CHINA MEDICAL UNIVERSITY

Applicant Address

No. 91 Syueshih Road China Medical University Taichung Taiwan

Inventors:

#	Inventor's Name	Inventor's Address
1	Sheng-Chu Kuo	Graduate Institute of Pharmaceutical Chemistry College of Pharmacy China Medical University Taichung Taiwan
2	Che-Ming Teng	Pharmacological Institutes College of Medicine National Taiwan University Taipei Taiwan
3	Kuo-Hsiung Lee	Natural Products Laboratory School of Pharmacy University of North Carolina Chapel Hill NC 27599 USA
4	Li-Jiau Huang	Graduate Institute of Pharmaceutical Chemistry College of Pharmacy China Medical University Taichung Taiwan
5	Li-Chen Chou	Graduate Institute of Pharmaceutical Chemistry College of Pharmacy China Medical University Taichung Taiwan
6	Chih-Shiang Chang	Graduate Institute of Pharmaceutical Chemistry College of Pharmacy China Medical University Taichung Taiwan
7	Chung-Ming Sun	Department of Applied Chemistry National Chiao-Tung University Hsinchu Taiwan
8	Tian-Shung Wu	Department of Chemistry National Cheng Kung University No. 1 Dasyue Rd. Tainan Taiwan
9	Shiow-Lin Pan	Pharmacological Institutes College of Medicine National Taiwan University Taipei Taiwan
10	Tzong-Der Way	School of Biological Science and Technology College of Medicine China Medical University Taichung Taiwan
11	Jang-Chang Lee	School of Pharmacy China Medical University Taichung Taiwan
12	Jing-Gung Chung	School of Biological Science and Technology Departments of Microbiology China Medical University Taichung Taiwan
13	Jai-Sing Yang	Departments of Pharmacology China Medical University Taichung Taiwan
14	Chien-Ting Chen	Graduate Institute of Pharmaceutical Chemistry College of Pharmacy China Medical University Taichung Taiwan
15	Ching-Che Huang	Graduate Institute of Pharmaceutical Chemistry College of Pharmacy China Medical University Taichung Taiwan
16	Shih-Ming Huang	Graduate Institute of Pharmaceutical Chemistry College of Pharmacy China Medical University Taichung Taiwan

PCT International Classification Number

A01N 57/00

PCT International Application Number

PCT/US2007/025056

PCT International Filing date

2007-12-07

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1	60/873,258	2006-12-07	U.S.A.