| Title of Invention | “IMPROVED PROCESS FOR THE PRODUCTION OF NUCLEOTIDE SUGARS” |
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| Abstract | The current invention provides methods (e.g., large-scale processes) for the production of nucleotide sugars, which are modified with a polymeric modifying group, such as poly(alkylene oxide) moieties (e.g., poly(ethylene glycol) or poly(propylene glycol)) moieties. A typical process of the invention includes anion exchange chromatography followed by an ultrafiltration procedure, such as tangential flow filtration. The process of the invention provides modified nucleotide sugars in unexpectedly high purity and high overall yields. |
| Full Text | PLEASE SEE THE SPECIFICATION ATTACHED. |
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| Patent Number | 271543 | ||||||||||||||||
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| Indian Patent Application Number | 8002/DELNP/2009 | ||||||||||||||||
| PG Journal Number | 09/2016 | ||||||||||||||||
| Publication Date | 26-Feb-2016 | ||||||||||||||||
| Grant Date | 24-Feb-2016 | ||||||||||||||||
| Date of Filing | 08-Dec-2009 | ||||||||||||||||
| Name of Patentee | RATIOPHARM GmbH | ||||||||||||||||
| Applicant Address | GRAF ARCO STREET 3,89079, ULM, GERMANY. | ||||||||||||||||
Inventors:
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| PCT International Classification Number | C07H 19/00 | ||||||||||||||||
| PCT International Application Number | PCT/US2008/066749 | ||||||||||||||||
| PCT International Filing date | 2008-06-12 | ||||||||||||||||
PCT Conventions:
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