Title of Invention	A PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE N-BENZYL-3-HYDROXYPYRROLIDINES
Abstract	The present invention relates to a facile, highly efficient and economical process for the preparation of optically active N-benzyl-3-hydroxypyrrolidine in high yield from a naturally occurring alkaloid vasicine. The natural alkaloid vasicine is used as a precursor of (S)-N-benzyl-3-hydroxypyrrolidine and (R)-N-benzyl-3-hydroxypyrrolidines which can easily be sourced from the medicinal plant Adatoda vasica by the method known in the art and transformed to optical isomers (R) and (S)-N-benzyl-3-hydroxypyrrolidine by the method described in the present invention.

Title of Invention

A PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE N-BENZYL-3-HYDROXYPYRROLIDINES

Abstract

The present invention relates to a facile, highly efficient and economical process for the preparation of optically active N-benzyl-3-hydroxypyrrolidine in high yield from a naturally occurring alkaloid vasicine. The natural alkaloid vasicine is used as a precursor of (S)-N-benzyl-3-hydroxypyrrolidine and (R)-N-benzyl-3-hydroxypyrrolidines which can easily be sourced from the medicinal plant Adatoda vasica by the method known in the art and transformed to optical isomers (R) and (S)-N-benzyl-3-hydroxypyrrolidine by the method described in the present invention.

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http://ipindiaonline.gov.in/patentsearch/GrantedSearch/viewdoc.aspx?id=Adyr8BLROz/YwKFlC0lM3A==&loc=+mN2fYxnTC4l0fUd8W4CAA==

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Patent Number

272479

Indian Patent Application Number

2648/DEL/2008

PG Journal Number

15/2016

Publication Date

08-Apr-2016

Grant Date

04-Apr-2016

Date of Filing

24-Nov-2008

Name of Patentee

COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

Applicant Address

ANUSANDHAN BHAWAN, RAFI MARG, NEW DELHI-110 001,INDIA

Inventors:

#	Inventor's Name	Inventor's Address
1	SUBHASH CHANDRA TANEJA	INDIAN INSTITUTE OF INTEGRATIVE MEDICINE JAMMU-TAWI
2	MUSHTAQ AHMAD AGA	INDIAN INSTITUTE OF INTEGRATIVE MEDICINE JAMMU-TAWI
3	BRIJESH KUMAR	INDIAN INSTITUTE OF INTEGRATIVE MEDICINE JAMMU-TAWI
4	VIJAY KUMAR SETHI	INDIAN INSTITUTE OF INTEGRATIVE MEDICINE JAMMU-TAWI
5	SAMAR SINGH ANDOTRA	INDIAN INSTITUTE OF INTEGRATIVE MEDICINE JAMMU-TAWI
6	GHULAM NABI QAZI	INDIAN INSTITUTE OF INTEGRATIVE MEDICINE JAMMU-TAWI

PCT International Classification Number

C07D

PCT International Application Number

N/A

PCT International Filing date

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1			NA