Title of Invention

“METHOD OF SYNTHESIZING SEVOFLURANE”

Abstract The invention provides a method of synthesizing sevoflurane. The method comprises the following steps that: taking hexafluoro isopropanol as the raw material and reacting it with trioxymethylene (or paraformaldehyde) in the presence of acids to generate di-hexafluoro isopropanol formal derivatives, adding anhydrous aluminum trihalide to generate halomethyl 2, 2,2-trifluoro-1-(trifluoromethyl) ethyl ether, then reacting the halomethyl compound with metal fluoride to form the sevoflurane. The method has low cost, and the reaction condition is easy to implement, and produces sevoflurane in large scale.
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Documents:

http://ipindiaonline.gov.in/patentsearch/GrantedSearch/viewdoc.aspx?id=nh6Qab9cX1Y4sfdgOxezPQ==&loc=+mN2fYxnTC4l0fUd8W4CAA==


Patent Number 272882
Indian Patent Application Number 9349/DELNP/2010
PG Journal Number 19/2016
Publication Date 06-May-2016
Grant Date 29-Apr-2016
Date of Filing 30-Dec-2010
Name of Patentee LUNAN PHARMACEUTICAL GROUP CORPORATION
Applicant Address No. 209  Hongqi Road  Linyi City  Shandong Province  276006 China.
Inventors:
# Inventor's Name Inventor's Address
1 Zhiquan ZHAO Dormitory of LUNAN PHARMACEUTICALS FACTORY Xiduan Beice Hongqi Road Linyi City Shandong Province 276005 China.
PCT International Classification Number C07C
PCT International Application Number PCT/CN2009/000750
PCT International Filing date 2009-07-02
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 200810129596 X 2008-07-02 China