Title of Invention	ORALLY-DISINTEGRATING TABLET AND MANUFACTURING METHOD THEREOF
Abstract	An orally-disintegrating tablet comprises a principal agent, a sugar alcohol powder and a sugar alcohol granule, wherein the orally-disintegrating tablet has a hardness of 30 N or greater. According to the present invention, a smooth swallowing orally-disintegrating tablet, for which both the mechanical strength and the disintegration properties in the buccal cavity are favorable with using a normal tableting machine and without using special devices and the feeling on the tongue and taste are favorable, is provided.

Title of Invention

ORALLY-DISINTEGRATING TABLET AND MANUFACTURING METHOD THEREOF

Abstract

An orally-disintegrating tablet comprises a principal agent, a sugar alcohol powder and a sugar alcohol granule, wherein the orally-disintegrating tablet has a hardness of 30 N or greater. According to the present invention, a smooth swallowing orally-disintegrating tablet, for which both the mechanical strength and the disintegration properties in the buccal cavity are favorable with using a normal tableting machine and without using special devices and the feeling on the tongue and taste are favorable, is provided.

Full Text	Orally-disintegrating tablet and Manufacturing Method Thereof BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to an orally-disintegrating tablet and a manufacturing method thereof, and more specifically relates to an orally-disintegrating tablet that disintegrates easily in the buccal cavity even though it has comparatively high hardness and a manufacturing method thereof. 2. Background Information [0002] Orally-disintegrating tablets are formulations that are easily taken by elderly people, children and patients that have difficulty swallowing. They are attracting attention as formulations that improve quality of life (QOL) because administration without water is possible. Typically, the orally-disintegrating tablets disintegrate rapidly after administration, but there is a problem in that they are difficult to use with automatic packaging machines due to their poor mechanical strength. [0003] In addition, in the manufacturing methods therefore, a method of pouring a dispersion liquid of a drug substance and an additive into PTP pockets or the like and lyophilizing them; a method using special machines such as a wet tableting machine; a method of tableting noncrystalline sugars at low pressure and humidifying and drying them to increase the hardness, and the like are known, but all of these methods are troublesome and complex and invite increases in production costs. Also, if the mechanical strength of the orally-disintegrating tablets themselves, which are obtained in this manner, is increased comparatively in consideration of handling properties, the property of disintegrating in the mouth is reduced, and a sufficiently satisfactory product is not obtained. [0004] Typically, sugar alcohols, which have good disintegration properties are used in a suitable manner as additives in orally-disintegrating tablets. However, sugar alcohols are normally in the form of fine powders, have poor molding properties and cannot be molded by tableting without modification. In addition, assuring tableting properties by mixing cellulose based excipients, such as crystal cellulose, into the sugar alcohol has been proposed (see, for example, Japanese Laid-Open Patent Application 2004-175796), but if the cellulose component is contained in large quantities, fiber remains when it is administered, and the feeling on the tongue and taste degrade. Furthermore, tableting is possible using granulated sugar alcohols, but the disintegration properties in the buccal cavity deteriorate, and tablets that require a minute or more to disintegrate are formed. SUMMARY OF THE INVENTION [0005] In light of the problems described above, it is an object of the present invention to provide an orally-disintegrating tablet that may be formed using a normal tableting machine, that reduces the disintegration time in the buccal cavity while imparting a hardness that is the same as an ordinary tablet and that has a suitable mechanical strength, and an manufacturing method thereof. [0006] The inventors has found, as a result of earnest investigations into additives for conventional orally-disintegrating preparations, that it is possible to unexpectedly obtain more satisfactory characteristics, by using a single ingredient in which forms are different, for both of the characteristics in the trade-off relationship between improving the mechanical strength of the orally-disintegrating tablets and the disintegration properties in the buccal cavity by mixing a granulation of sugar alcohol, which is superior in molding properties but degrades the disintegration properties, into a powder sugar alcohol, which has superior disintegration properties but degrades the molding properties. [0007] The present invention provides a orally-disintegrating tablet comprising a principal agent, a sugar alcohol powder and a sugar alcohol granule, wherein the orally-disintegrating tablet has a hardness of 30 N or greater. Further, the present invention provides a manufacturing method for an orally-disintegrating tablet comprising: mixing a sugar alcohol powder and a sugar alcohol granule with a principal agent to obtain a mixture and compression-molding the mixture at a hardness of 30 N or greater. [0008] According to the present invention, a smooth swallowing orally-disintegrating tablet, for which both the mechanical strength and the disintegration properties in the buccal cavity are favorable with using a normal tableting machine and without using special devices and the feeling on the tongue and taste are favorable, and a manufacturing method thereof are provided. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS [0009] An orally-disintegrating tablet of the present invention contains at least a principal agent and a sugar alcohol. There is no particular restriction on the principal agent here, and examples of the principal agent include medicines for motion sickness, analgesic antipyretic, aromatic stomachic, digestant, antacid agent, vitamin, nutrient tonic, enzyme preparation, nutrient tonic supplement, anti-inflammatory, antirheumatic drug, gout remedy, antihistamine, allergy agent, antibiotic agent, synthetic antibacterial, medicine for dental and oral use, bronchodilator, cough remedy, expectorant drug, sleep sedative, anxiolytic agent, antiepileptic drug, psychoneurotic agent, autonomic agent, central nervous system drug, antispasmodic agent, ameliorant of cerebral metabolism, ameliorant of cerebral circulation, antiParkinson's disease agent, Alzheimer therapeutic agent, cardiotonic agent, antiarrhythmia agent, diuretic agent, vasoconstrictor, vasodilatation agent, hypotensive agent, antihyperlipemia agent, constipating agent, peptic ulcer agent, cathartic, hormone agent, diabetes agent, and the like, as well as prodrugs. [0010] The primary agent may have any form, powder, solid, granulated powder or the like. There is no particular restriction on the size, and it may be suitably prepared in consideration of the feel on the tongue when administered as an orally-disintegrating tablet. Moreover, a method for making the grain diameters uniform such as a sieve or membrane filter and a method for pulverizing, such as a ball mill pulverizer, hammer mill pulverizer, or pin mill pulverizer may cited for giving the principal agent a suitable shape and size. In addition, it is suitable for the principal agent to be about 0.1 % or more by weight, and more suitably about 1 % or more by weight, as well as about 50 % or less by weight of the total weight of the orally-disintegrating tablet. [0011] Examples of the sugar alcohol include D-mannitol, erythritol, sorbitol, xylitol, trehalose, maltitol, lactitol, and the like. Among these, it is preferably D-mannitol, erythritol, sorbitol, xylitol, and the like. These can be used alone or as mixture of two or more. [0012] The orally-disintegrating tablet of the present invention is formed using at least both a powder sugar alcohol and a granulated sugar alcohol. Powder means that it is not in a granulated form. Normally, the average particle size in powder sugar alcohols is cited as being smaller than about 50 urn, and typically, use of ones about 40 um or less is preferable. [0013] The granule is a sugar alcohol granulated by a method commonly known in the field, and for example, either wet granulation or dry granulation may be used for the manufacturing method. In the case of wet granulation, granulation may be done by a variety of devices, such as a fluid bed granulator and dryer, agitating granulator, cylindrical extrusion granulator, rolling fluid bed granulation and coating machine, or spray drying. In the case of dry granulation, granulation may be done using various devices, dry granulators, such as roller compactors, slug tableting machines, and the like. Among these, forming using a wet granulation method is preferable. Since wet granulation methods yield more uniform particle diameters than dry granulation methods, and the proportion of fine powder is reduced, a granulated powder with better molding properties may typically be obtained. Moreover, when the sugar alcohol is granulated, any additives that may be added for pharmaceutical products, such as sweeteners, disintegration agents and colorants, may be added, as will be discussed in the following. [0014] It is preferable for the granulated substance to have, for example, an average particle diameter of about 50 m or greater, about 70m or greater, about 80 m or greater, and about 500 m or less, about 400 m or less, about 300 m or less, about 200 m or less, about 150 m or less. Particularly, it is preferably to have an average particle diameter of at least about 80 m. From another point of view, it is suitable for the granulated substance to have a particle diameter of about 2 to about 20 times, preferably about 3 to about 8 times that of the powder sugar alcohol. [0015] It is suitable for the mixing ratio for the powder sugar alcohol and the granulated sugar alcohol to be a ratio by weight of about 8:1 to about 1:4, preferably about 6:1 to about 1:2, more preferably about 4:1 to 1:1 for the sugar alcohols. This is because molding becomes difficult for the tablets if there is too much of the powder, and if there is too much of the granulated substance, the orally-disintegration time tends to increase. Because of the mixing of the powder sugar alcohol and the granulated sugar alcohol in this range, there is a difference from a comparatively low density tablet, where the voids between the sugar alcohol particles like those in an orally-disintegrating tablet formed with granulated sugar alcohol only are connected, in that the voids between the particles are present independently to a moderate degree, and the powder sugar alcohol is dispersed in the vicinity of these voids. While molding with comparatively high hardness is possible because of this particle distribution, the tablet can easily be disintegrated in a short period of time by the saliva in the buccal cavity. Moreover, its is preferable for the independent voids here to be at least approximately the same as the average particle diameter of the granulated sugar alcohol or to be voids with smaller diameters than these, and it is preferable for these independent voids be present to a degree of about 50% or more, about 60 % ore more, and about 70 % or more of the total void volume. [0016] In addition, in the present invention, it is suitable for the sugar alcohol powder and the sugar alcohol granules to be about 50 % or more, about 55 % or more, about 60 % or more by weight of the total weight of the orally-disintegrating preparation. There is no particular upper restriction, but, normally it is about 70 % by weight. By including the sugar alcohols in this range, it is possible to assure both the disintegration properties and molding properties with the single sugar alcohol component, and along with disintegration happening smoothly in the buccal cavity while there is suitable mechanical strength, it is possible to make it easy to swallow with a good feeling on the tongue, feeling of roughness and flavor in the buccal cavity. [0017] Furthermore, normally used additives and the like may be included in the orally-disintegrating tablet of the present invention. Examples of the additive include disintegrating agent, excipient, binder, solubilizing agent, lubricant, fluidiser, sweetener, fragrance, foaming agent, surfactant, pH adjuster, preservative, colorant, and the like. [0018] Examples of the disintegrating agent include crospovidone, sodium starch glycolate, sodium carboxymethyl starch, starch, partially pregelatinized starch, cornstarch, lactose, calcium carbonate, precipitated calcium carbonate, calcium citrate, light silicic anhydride, synthetic aluminum silicate crystalline cellulose, low substitution degree hydroxypropylcellulose, croscarmellose, sodium croscarmellose, calcium carboxymethylcellulose, carmellose, hydroxypropyl starch, and the like. These can be used alone or as mixture of two or more. Among these, it is preperably croscarmellose, sodium starch glycolate, carmellose, starch, hydroxypropyl starch, crospovidone, and the like. The amount of the disintegrating agent can be, for example, included about 0.1 % or more, preferably about 0.5 % or more, and more preferably about 2 % or more by weight with respect to the total weight of the orally-disintegrating tablet. Also, it can be included about 30 % or less, preferably about 25 % or less, and more preferably about 15 % by weight. [0019] Examples of the excipient include glucose, fructose, lactose, sucrose, hydrogenated maltose, and the like. These can be used alone or as mixture of two or more. Examples of the binder include a water-soluble substance such as gelatine, agar, alginic acid, sodium alginate, dextrin, xanthan gum, arabian gum, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, polyvinylpyrrolidone, partially saponification polyvinyl alcohol, methylcellulose, pullulan, partially pregelatinized starch, sugar, and the like. These can be used alone or as mixture of two or more. [0020] Examples of the solubilizing agent include magnesium oxide, calcium oxide, sodium citrate, magnesium chloride, sodium carbonate, sodium bicarbonate, and the like. These can be used alone or as mixture of two or more. [0021] Examples of the lubricant include magnesium stearate, calcium stearate, talc, sucrose fatty acid ester, polyethyleneglycol, stearic acid, light silicic anhydride, hydrogenated rape oil, hydrogenated castor oil, glycerin fatty acid ester, sodium stearyl fumarate, sodium benzoate, L-leucin, L-valine, and the like. These can be used alone or as mixture of two or more. [0022] Examples of the fluidizer include hydrated silicon dioxide, light silicic anhydride, and the like. Examples of the sweetener include aspartame, sodium saccharin, dipotassium glycyrrhizinate, stevia, thaumatin, and the like. These can be used alone or as mixture of two or more. Examples of the fragrance include mint, lemon or orange extract, and the like. Examples of the foaming agent include tartrate, citrate, bicarbonate, and the like. [0023] Examples of the surfactant include an anionic surfactant such as sodium alkylsulfate; a nonionic surfactant such as sucrose fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene fatty acid ester and polyoxyethylene castor oil derivatives, and the like. These can be used alone or as mixture of two or more. Examples of the pH adjuster include an organic acid such as glycin, sodium acid carbonate, dibasic calcium phosphate, dibasic sodium phosphate, acetic acid, succinic acid, tartaric acid, fumaric acid, and citric acid. Examples of the preservative include benzoic acid, parahydroxybenzoic acid, and the like or a salt thereof. Examples of the colorant include yellow oxide of iron, yellow iron sesquioxide, iron sesquioxide (red), orange essence, brown iron oxide, caramel, light silicic anhydride, Food Blue No.5, Food Yellow No.4, Food Yellow No.4 aluminum lake, Food Yellow No.5, Food Red No.2 (Amaranth), Food Red No.3, Food Red No.102, talc, sodium tetrafluorescein, green tea powder, Vitamin C, and the like. [0024] It is preferable for the orally-disintegrating tablet of the present invention to have a hardness that does not allow it to be destroyed by being removed from a packaging container or the like. Specifically, it is suitably 30 N or greater, preferably 35 N or greater, more preferably 40 N or greater. The hardness of preparations may be measured using a tablet hardness gauge (Schleuinger Inc., Tablet Tester 6D), for example. [0025] There is no particular restriction on the shape of the orally-disintegrating preparation of the present invention, and it may be made into a disk shape, donut shape, polygonal disk shape, spherical shape, elliptical shape, capsule shape or the like. Among these, the disk shape, which is the normal tablet shape, is preferable. There is no particular restriction on the size, and it is suitable for it to be slightly large so that it cannot be directly swallowed. For example, a diameter of about 3 to about 30 mm and a thickness of about 1 to about 10 mm are preferable. [0026] In addition, the manufacturing method for the orally-disintegrating tablet of the present invention comprises mixing the sugar alcohol powder and sugar alcohol granules into the principal agent and molding. [0027] The mixing of the principal agent, sugar alcohol powder, sugar alcohol granules and optionally an additive described above may be carried out using commonly known devices and the like by a method commonly known in the field. The principal agent and the sugar alcohol powder are normally not ones that have been granulated, and the sugar alcohol granules have been granulated in advance as described above, at mixing. These may be mixed in any order or at the same time. The mixing at this time is preferably carried out without wetting or adding moisture. Here, wetting or adding moisture means water content of more than about 5% of the total weight of the orally-disintegrating tablet. Therefore, without wetting and without the addition of moisture means mixing water of about 5% or less to the total weight of the orally-disintegrating tablet. [0028] It is suitable to use commonly known devices or the like, compress and carry out the molding of the mixture by methods that are commonly known in the field. For example, a tableting mortar and upper and lower pestles for tableting are used, and a hydraulic hand press, a single punch tableting machine, a rotary tableting machine or the like is used for the device for compression molding. [0029] The tablets obtained in compression molding have a suitable hardness, for example about 30 N or greater, and suitable independent voids are assured in the tablets. Adjustment and execution so that there can be rapid disintegration are necessary for the orally-disintegrating tablets. For example, there is no particular restriction for the tableting pressure, and it may be adjusted suitably according to the device used, principles, size of tablet, type of principal agent and the like. When a device like that described above is used, for example, a tableting pressure of about 50 kg/cm2 or greater and about 1500 kg/cm2 or less is suitable, and about 300 kg/cm2 or greater and about 1000 kg/cm2 or less is preferable. Moreover, it is also suitable for being carried out without wetting and without moisture being added at compression molding. Typically, with molding as a production method for orally-disintegrating tablets, there is a method of drying after the mixed powder is tableted in a wet state (wet tableting), a method of mixing in a noncrystalline sugar in advance, tableting at a comparatively low pressure, adding moisture and drying (aging) after that to increase the tablet hardness, and the like. These methods may be used in the present invention, but as was described earlier, in molding methods for normal tablets, there is merit in being able to manufacture them conveniently without requiring special processes like these. [0030] In the following, examples of the orally-disintegrating tablet of the present invention and the manufacturing method thereof will be described in detail. Example 1 500 g of D-mannitol was introduced into a fluid bed granulator (Powerex Corp., Multiplex), a 10% aqueous solution of D-mannitol (Nikken Fine Chemical Co., Ltd.) sprayed as the spraying fluid and fluid bed granulation carried out. After 500g was sprayed, it was dried and granulated mannitol was obtained (average particle diameter 150 to 220 urn). In addition, using the same method, 500 g of erythritol (Mitsubishi Chemical Corp.) was introduced into, a 10% aqueous solution of erythritol sprayed as the spray fluid, fluid bed granulated, sprayed 500 g of the aqueous solution, after that dried, and granulated erythritol obtained (average particle diameter 80 to 130 urn). For the commercial sugar alcohol granules, direct tableting mannitol (Patikku 100M, Merck, granulated mannitol, average particle diameter 90 to 120 (m) was used for the granulated substance. [0031] Crystal cellulose (Asahi Kasei Chemicals Corp., Seorasu PH301), crospovidon XL10 (ISP), aspartame (Ajinomoto Co., Inc), magnesium stearate (Taihei Chemical Industrial Co., Ltd.), crosscarmellose (Asahi Kasei Chemicals Corp.) and hydroxypropyl starch (Fruend Industrial Co., Ltd.) were used as additives. [0032] The various compounds described above were tableted so as to have a diameter of 7 mm with a weight of 100 mg per tablet in a rotary tableting machine according to the recipe given in Table 1 through Table 3. In addition, as a comparative example, an orally-disintegrating preparation was tableted using only the powder sugar alcohol or only the granulated substance as shown in Table 4. [0033] Table 1 Example 1 2 3 4 5 6 7 8 9 10 D-mannitol 37.5 45 50 37.5 45 50 56.3 37.5 45 50 Granulated Mannitol 37.5 30 25 Direct Tableting 37.5 30 25 18.7 Mannitol Granulated Erythritol 37.5 30 25 Crystal Cellulose 13 13 13 13 13 13 13 13 13 13 Crospovidon 10 10 10 10 10 10 10 10 10 10 Aspartame 1 1 1 1 1 1 1 1 1 1 Magnesium Stearate 1 1 1 1 1 1 1 1 1 1 Tableting 450 700 850 450 650 800 950 500 750 900 Pressure (kgf/cm2) Hardness (N) 40 40 35 40 45 35 30 40 40 30 Disintegration Time (s) 28 20 15 25 15 13 10 24 18 11 [0034] Table 2 Example 11 12 13 14 D-mannitol 45 45 45 45 Direct Tableting Mannitol 30 30 30 30 Crystal Cellulose 13 13 13 8 Crospovidon 2 5 Crosscarmellose 5 5 Hydroxypropyl Starch 8 5 5 10 Aspartame 1 1 1 1 Magnesium Stearate 1 1 1 1 Tableting Pressure (kgf/cm2) 500 650 700 800 Hardness (N) 45 40 37 40 Disintegration Time (s) 25 19 27 24 [0035] Table 3 Example 15 16 17 18 Acetaminophen 15 Risperidone 2 Zolpidem tartrate 10 Amlodipine Besilate 3.47 D-mannitol 36 39 45 43.53 Granulated Mannitol 24 26 28 28 Direct Tableting Mannitol 37.5 Granulated Erythritol Crystal Cellulose 13 13 13 13 Crospovidon 10 10 10 10 Aspartame 1 1 1 1 Magnesium Stearate 1 1 1 1 Tableting Pressure (kgf/cm2) 800 750 650 650 Hardness (N) 35 40 45 40 Disintegration Time (s) 28 20 15 18 [0036] Table 4 Comparative Example 1 2 D-mannitol 75 Granulated Mannitol Direct Tableting Mannitol 75 Granulated Erythritol Crystal Cellulose 13 13 Crospovidon 10 10 Aspartame 1 T—1 Magnesium Stearate 1 1 Tableting Pressure (kgf/cm2) 1000 600 Hardness (N) Tableting was 40 Disintegration Time (s) impossible 45 [0037] From the results in Tables 1 through 4, the hardness was 30 N or greater for all of the examples of the present invention, but even though it was high, the buccal cavity disintegration time was within 30 sec, and a rapidly disintegrating orally-disintegrating tablet was obtained. Moreover, all of the orally-disintegrating tablets in the examples had a good feel on the tongue in the buccal cavity, and there was easy swallowing with no feeling of roughness or sense of discomfort. On the other hand, when only the powder sugar alcohol was used in the comparative examples, tableting was impossible, and tablets could not be formed. In addition, when only the granulated sugar alcohol was used, the buccal cavity disintegration time increased. [0038] Regardless of the type of principal agent and regardless of the part that is disintegrated, the present invention may be used over a wide range of formulations that disintegrate and administer the agent. This application claims priority to Japanese Patent Application No. 2007-103925. The entire disclosure of Japanese Patent Application No. 2007-103925 is hereby incorporated herein by reference. While only selected embodiments have been chosen to illustrate the present invention, it will be apparent to those skilled in the art from this disclosure that various changes and modifications can be made herein without departing from the scope of the invention as defined in the appended claims. Furthermore, the foregoing descriptions of the embodiments according to the present invention are provided for illustration only, and not for the purpose of limiting the invention as defined by the appended claims and their equivalents. Thus, the scope of the invention is not limited to the disclosed embodiments. What is claimed is: 1. An orally-disintegrating tablet comprising a principal agent, a sugar alcohol powder and a sugar alcohol granule, wherein the orally-disintegrating tablet has a hardness of 30 N or greater. 2. The orally-disintegrating tablet according to claim 1, wherein the sugar alcohol granule has a particle diameter of 2 to 20 times that of the sugar alcohol powder. 3. The orally-disintegrating tablet according to claim 1, wherein the sugar alcohol powder is at least one compound selected from the group consisting of D-mannitol, erythritol, sorbitol, xylitol. 4. The orally-disintegrating tablet according to claim 1, wherein the sugar alcohol granule is formed by a wet granulation method. 5. The orally-disintegrating tablet according to claim 4, wherein the sugar alcohol granule is formed by a method of agitating and granulating, fluid bed granulating or spray drying. 6. The orally-disintegrating tablet according to claim 1, wherein the sugar alcohol granule has a particle diameter of 80 m or more. 7. The orally-disintegrating tablet according to claim 1, wherein a mixture ratio of the sugar alcohol powder and the sugar alcohol granule is of 8:1 to 1:4 by weight of the total weight of the sugar alcohols. 8. The orally-disintegrating tablet according to claim 1, wherein an amount of the sugar alcohol powder and the sugar alcohol granule is 50 % or more by weight of the total weight of the orally-disintegrating tablet. 9. The orally-disintegrating tablet according to claim 1, further comprising at least one compound selected from the group consisting of croscarmellose, sodium starch glycolate, carmellose, starch, hydroxypropyl starch and crospovidone. 10. A manufacturing method for an orally-disintegrating tablet comprising: mixing a sugar alcohol powder and a sugar alcohol granule with a principal agent to obtain a mixture and compression-molding the mixture at a hardness of 30 N or greater. 11. The method according to claim 10, wherein the mixing and compression-molding are carried out without wetting and without addition of moisture. An orally-disintegrating tablet comprises a principal agent, a sugar alcohol powder and a sugar alcohol granule, wherein the orally-disintegrating tablet has a hardness of 30 N or greater. According to the present invention, a smooth swallowing orally-disintegrating tablet, for which both the mechanical strength and the disintegration properties in the buccal cavity are favorable with using a normal tableting machine and without using special devices and the feeling on the tongue and taste are favorable, is provided.

Full Text

Orally-disintegrating tablet and Manufacturing Method Thereof
BACKGROUND OF THE INVENTION
1. Field of the Invention
[0001]
The present invention relates to an orally-disintegrating tablet and a
manufacturing method thereof, and more specifically relates to an orally-disintegrating
tablet that disintegrates easily in the buccal cavity even though it has comparatively
high hardness and a manufacturing method thereof.
2. Background Information
[0002]
Orally-disintegrating tablets are formulations that are easily taken by elderly
people, children and patients that have difficulty swallowing. They are attracting
attention as formulations that improve quality of life (QOL) because administration
without water is possible.
Typically, the orally-disintegrating tablets disintegrate rapidly after
administration, but there is a problem in that they are difficult to use with automatic
packaging machines due to their poor mechanical strength.
[0003]
In addition, in the manufacturing methods therefore, a method of pouring a
dispersion liquid of a drug substance and an additive into PTP pockets or the like and
lyophilizing them; a method using special machines such as a wet tableting machine; a
method of tableting noncrystalline sugars at low pressure and humidifying and drying
them to increase the hardness, and the like are known, but all of these methods are
troublesome and complex and invite increases in production costs. Also, if the
mechanical strength of the orally-disintegrating tablets themselves, which are obtained
in this manner, is increased comparatively in consideration of handling properties, the
property of disintegrating in the mouth is reduced, and a sufficiently satisfactory
product is not obtained.
[0004]
Typically, sugar alcohols, which have good disintegration properties are used in
a suitable manner as additives in orally-disintegrating tablets. However, sugar
alcohols are normally in the form of fine powders, have poor molding properties and
cannot be molded by tableting without modification. In addition, assuring tableting
properties by mixing cellulose based excipients, such as crystal cellulose, into the sugar
alcohol has been proposed (see, for example, Japanese Laid-Open Patent Application
2004-175796), but if the cellulose component is contained in large quantities, fiber
remains when it is administered, and the feeling on the tongue and taste degrade.
Furthermore, tableting is possible using granulated sugar alcohols, but the

disintegration properties in the buccal cavity deteriorate, and tablets that require a
minute or more to disintegrate are formed.
SUMMARY OF THE INVENTION
[0005]
In light of the problems described above, it is an object of the present invention
to provide an orally-disintegrating tablet that may be formed using a normal tableting
machine, that reduces the disintegration time in the buccal cavity while imparting a
hardness that is the same as an ordinary tablet and that has a suitable mechanical
strength, and an manufacturing method thereof.
[0006]
The inventors has found, as a result of earnest investigations into additives for
conventional orally-disintegrating preparations, that it is possible to unexpectedly
obtain more satisfactory characteristics, by using a single ingredient in which forms are
different, for both of the characteristics in the trade-off relationship between improving
the mechanical strength of the orally-disintegrating tablets and the disintegration
properties in the buccal cavity by mixing a granulation of sugar alcohol, which is
superior in molding properties but degrades the disintegration properties, into a
powder sugar alcohol, which has superior disintegration properties but degrades the
molding properties.
[0007]
The present invention provides a orally-disintegrating tablet comprising a
principal agent, a sugar alcohol powder and a sugar alcohol granule, wherein the
orally-disintegrating tablet has a hardness of 30 N or greater.
Further, the present invention provides a manufacturing method for an
orally-disintegrating tablet comprising:
mixing a sugar alcohol powder and a sugar alcohol granule with a principal
agent to obtain a mixture and
compression-molding the mixture at a hardness of 30 N or greater.
[0008]
According to the present invention, a smooth swallowing orally-disintegrating
tablet, for which both the mechanical strength and the disintegration properties in the
buccal cavity are favorable with using a normal tableting machine and without using
special devices and the feeling on the tongue and taste are favorable, and a
manufacturing method thereof are provided.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
[0009]
An orally-disintegrating tablet of the present invention contains at least a

principal agent and a sugar alcohol.
There is no particular restriction on the principal agent here, and examples of
the principal agent include medicines for motion sickness, analgesic antipyretic,
aromatic stomachic, digestant, antacid agent, vitamin, nutrient tonic, enzyme
preparation, nutrient tonic supplement, anti-inflammatory, antirheumatic drug, gout
remedy, antihistamine, allergy agent, antibiotic agent, synthetic antibacterial, medicine
for dental and oral use, bronchodilator, cough remedy, expectorant drug, sleep sedative,
anxiolytic agent, antiepileptic drug, psychoneurotic agent, autonomic agent, central
nervous system drug, antispasmodic agent, ameliorant of cerebral metabolism,
ameliorant of cerebral circulation, antiParkinson's disease agent, Alzheimer therapeutic
agent, cardiotonic agent, antiarrhythmia agent, diuretic agent, vasoconstrictor,
vasodilatation agent, hypotensive agent, antihyperlipemia agent, constipating agent,
peptic ulcer agent, cathartic, hormone agent, diabetes agent, and the like, as well as
prodrugs.
[0010]
The primary agent may have any form, powder, solid, granulated powder or
the like. There is no particular restriction on the size, and it may be suitably prepared
in consideration of the feel on the tongue when administered as an orally-disintegrating
tablet. Moreover, a method for making the grain diameters uniform such as a sieve or
membrane filter and a method for pulverizing, such as a ball mill pulverizer, hammer
mill pulverizer, or pin mill pulverizer may cited for giving the principal agent a suitable
shape and size. In addition, it is suitable for the principal agent to be about 0.1 % or
more by weight, and more suitably about 1 % or more by weight, as well as about 50 %
or less by weight of the total weight of the orally-disintegrating tablet.
[0011]
Examples of the sugar alcohol include D-mannitol, erythritol, sorbitol, xylitol,
trehalose, maltitol, lactitol, and the like. Among these, it is preferably D-mannitol,
erythritol, sorbitol, xylitol, and the like. These can be used alone or as mixture of two
or more.
[0012]
The orally-disintegrating tablet of the present invention is formed using at least
both a powder sugar alcohol and a granulated sugar alcohol. Powder means that it is
not in a granulated form. Normally, the average particle size in powder sugar alcohols
is cited as being smaller than about 50 urn, and typically, use of ones about 40 um or
less is preferable.
[0013]
The granule is a sugar alcohol granulated by a method commonly known in the
field, and for example, either wet granulation or dry granulation may be used for the
manufacturing method. In the case of wet granulation, granulation may be done by a

variety of devices, such as a fluid bed granulator and dryer, agitating granulator,
cylindrical extrusion granulator, rolling fluid bed granulation and coating machine, or
spray drying. In the case of dry granulation, granulation may be done using various
devices, dry granulators, such as roller compactors, slug tableting machines, and the
like. Among these, forming using a wet granulation method is preferable. Since wet
granulation methods yield more uniform particle diameters than dry granulation
methods, and the proportion of fine powder is reduced, a granulated powder with
better molding properties may typically be obtained.
Moreover, when the sugar alcohol is granulated, any additives that may be
added for pharmaceutical products, such as sweeteners, disintegration agents and
colorants, may be added, as will be discussed in the following.
[0014]
It is preferable for the granulated substance to have, for example, an average
particle diameter of about 50 m or greater, about 70m or greater, about 80 m or
greater, and about 500 m or less, about 400 m or less, about 300 m or less, about 200
m or less, about 150 m or less. Particularly, it is preferably to have an average
particle diameter of at least about 80 m. From another point of view, it is suitable for
the granulated substance to have a particle diameter of about 2 to about 20 times,
preferably about 3 to about 8 times that of the powder sugar alcohol.
[0015]
It is suitable for the mixing ratio for the powder sugar alcohol and the
granulated sugar alcohol to be a ratio by weight of about 8:1 to about 1:4, preferably
about 6:1 to about 1:2, more preferably about 4:1 to 1:1 for the sugar alcohols. This is
because molding becomes difficult for the tablets if there is too much of the powder,
and if there is too much of the granulated substance, the orally-disintegration time
tends to increase. Because of the mixing of the powder sugar alcohol and the
granulated sugar alcohol in this range, there is a difference from a comparatively low
density tablet, where the voids between the sugar alcohol particles like those in an
orally-disintegrating tablet formed with granulated sugar alcohol only are connected, in
that the voids between the particles are present independently to a moderate degree,
and the powder sugar alcohol is dispersed in the vicinity of these voids. While
molding with comparatively high hardness is possible because of this particle
distribution, the tablet can easily be disintegrated in a short period of time by the saliva
in the buccal cavity. Moreover, its is preferable for the independent voids here to be at
least approximately the same as the average particle diameter of the granulated sugar
alcohol or to be voids with smaller diameters than these, and it is preferable for these
independent voids be present to a degree of about 50% or more, about 60 % ore more,
and about 70 % or more of the total void volume.
[0016]

In addition, in the present invention, it is suitable for the sugar alcohol powder
and the sugar alcohol granules to be about 50 % or more, about 55 % or more, about
60 % or more by weight of the total weight of the orally-disintegrating preparation.
There is no particular upper restriction, but, normally it is about 70 % by weight. By
including the sugar alcohols in this range, it is possible to assure both the disintegration
properties and molding properties with the single sugar alcohol component, and along
with disintegration happening smoothly in the buccal cavity while there is suitable
mechanical strength, it is possible to make it easy to swallow with a good feeling on the
tongue, feeling of roughness and flavor in the buccal cavity.
[0017]
Furthermore, normally used additives and the like may be included in the
orally-disintegrating tablet of the present invention. Examples of the additive include
disintegrating agent, excipient, binder, solubilizing agent, lubricant, fluidiser, sweetener,
fragrance, foaming agent, surfactant, pH adjuster, preservative, colorant, and the like.
[0018]
Examples of the disintegrating agent include crospovidone, sodium starch
glycolate, sodium carboxymethyl starch, starch, partially pregelatinized starch,
cornstarch, lactose, calcium carbonate, precipitated calcium carbonate, calcium citrate,
light silicic anhydride, synthetic aluminum silicate crystalline cellulose, low substitution
degree hydroxypropylcellulose, croscarmellose, sodium croscarmellose, calcium
carboxymethylcellulose, carmellose, hydroxypropyl starch, and the like. These can be
used alone or as mixture of two or more. Among these, it is preperably croscarmellose,
sodium starch glycolate, carmellose, starch, hydroxypropyl starch, crospovidone, and
the like. The amount of the disintegrating agent can be, for example, included about
0.1 % or more, preferably about 0.5 % or more, and more preferably about 2 % or more
by weight with respect to the total weight of the orally-disintegrating tablet. Also, it
can be included about 30 % or less, preferably about 25 % or less, and more preferably
about 15 % by weight.
[0019]
Examples of the excipient include glucose, fructose, lactose, sucrose,
hydrogenated maltose, and the like. These can be used alone or as mixture of two or
more.
Examples of the binder include a water-soluble substance such as gelatine, agar,
alginic acid, sodium alginate, dextrin, xanthan gum, arabian gum,
hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose,
polyvinylpyrrolidone, partially saponification polyvinyl alcohol, methylcellulose,
pullulan, partially pregelatinized starch, sugar, and the like. These can be used alone
or as mixture of two or more.
[0020]

Examples of the solubilizing agent include magnesium oxide, calcium oxide,
sodium citrate, magnesium chloride, sodium carbonate, sodium bicarbonate, and the
like. These can be used alone or as mixture of two or more.
[0021]
Examples of the lubricant include magnesium stearate, calcium stearate, talc,
sucrose fatty acid ester, polyethyleneglycol, stearic acid, light silicic anhydride,
hydrogenated rape oil, hydrogenated castor oil, glycerin fatty acid ester, sodium stearyl
fumarate, sodium benzoate, L-leucin, L-valine, and the like. These can be used alone
or as mixture of two or more.
[0022]
Examples of the fluidizer include hydrated silicon dioxide, light silicic
anhydride, and the like.
Examples of the sweetener include aspartame, sodium saccharin, dipotassium
glycyrrhizinate, stevia, thaumatin, and the like. These can be used alone or as mixture
of two or more.
Examples of the fragrance include mint, lemon or orange extract, and the like.
Examples of the foaming agent include tartrate, citrate, bicarbonate, and the
like.
[0023]
Examples of the surfactant include an anionic surfactant such as sodium
alkylsulfate; a nonionic surfactant such as sucrose fatty acid ester, polyoxyethylene
sorbitan fatty acid ester, polyoxyethylene fatty acid ester and polyoxyethylene castor oil
derivatives, and the like. These can be used alone or as mixture of two or more.
Examples of the pH adjuster include an organic acid such as glycin, sodium
acid carbonate, dibasic calcium phosphate, dibasic sodium phosphate, acetic acid,
succinic acid, tartaric acid, fumaric acid, and citric acid.
Examples of the preservative include benzoic acid, parahydroxybenzoic acid,
and the like or a salt thereof.
Examples of the colorant include yellow oxide of iron, yellow iron sesquioxide,
iron sesquioxide (red), orange essence, brown iron oxide, caramel, light silicic
anhydride, Food Blue No.5, Food Yellow No.4, Food Yellow No.4 aluminum lake, Food
Yellow No.5, Food Red No.2 (Amaranth), Food Red No.3, Food Red No.102, talc,
sodium tetrafluorescein, green tea powder, Vitamin C, and the like.
[0024]
It is preferable for the orally-disintegrating tablet of the present invention to
have a hardness that does not allow it to be destroyed by being removed from a
packaging container or the like. Specifically, it is suitably 30 N or greater, preferably
35 N or greater, more preferably 40 N or greater. The hardness of preparations may be
measured using a tablet hardness gauge (Schleuinger Inc., Tablet Tester 6D), for

example.
[0025]
There is no particular restriction on the shape of the orally-disintegrating
preparation of the present invention, and it may be made into a disk shape, donut
shape, polygonal disk shape, spherical shape, elliptical shape, capsule shape or the like.
Among these, the disk shape, which is the normal tablet shape, is preferable. There is
no particular restriction on the size, and it is suitable for it to be slightly large so that it
cannot be directly swallowed. For example, a diameter of about 3 to about 30 mm and
a thickness of about 1 to about 10 mm are preferable.
[0026]
In addition, the manufacturing method for the orally-disintegrating tablet of the
present invention comprises mixing the sugar alcohol powder and sugar alcohol
granules into the principal agent and molding.
[0027]
The mixing of the principal agent, sugar alcohol powder, sugar alcohol granules
and optionally an additive described above may be carried out using commonly known
devices and the like by a method commonly known in the field. The principal agent
and the sugar alcohol powder are normally not ones that have been granulated, and the
sugar alcohol granules have been granulated in advance as described above, at mixing.
These may be mixed in any order or at the same time.
The mixing at this time is preferably carried out without wetting or adding
moisture. Here, wetting or adding moisture means water content of more than about
5% of the total weight of the orally-disintegrating tablet. Therefore, without wetting
and without the addition of moisture means mixing water of about 5% or less to the
total weight of the orally-disintegrating tablet.
[0028]
It is suitable to use commonly known devices or the like, compress and carry
out the molding of the mixture by methods that are commonly known in the field. For
example, a tableting mortar and upper and lower pestles for tableting are used, and a
hydraulic hand press, a single punch tableting machine, a rotary tableting machine or
the like is used for the device for compression molding.
[0029]
The tablets obtained in compression molding have a suitable hardness, for
example about 30 N or greater, and suitable independent voids are assured in the
tablets. Adjustment and execution so that there can be rapid disintegration are
necessary for the orally-disintegrating tablets. For example, there is no particular
restriction for the tableting pressure, and it may be adjusted suitably according to the
device used, principles, size of tablet, type of principal agent and the like. When a
device like that described above is used, for example, a tableting pressure of about 50

kg/cm2 or greater and about 1500 kg/cm2 or less is suitable, and about 300 kg/cm2 or
greater and about 1000 kg/cm2 or less is preferable.
Moreover, it is also suitable for being carried out without wetting and without
moisture being added at compression molding.
Typically, with molding as a production method for orally-disintegrating
tablets, there is a method of drying after the mixed powder is tableted in a wet state
(wet tableting), a method of mixing in a noncrystalline sugar in advance, tableting at a
comparatively low pressure, adding moisture and drying (aging) after that to increase
the tablet hardness, and the like. These methods may be used in the present invention,
but as was described earlier, in molding methods for normal tablets, there is merit in
being able to manufacture them conveniently without requiring special processes like
these.
[0030]
In the following, examples of the orally-disintegrating tablet of the present
invention and the manufacturing method thereof will be described in detail.
Example 1
500 g of D-mannitol was introduced into a fluid bed granulator (Powerex Corp.,
Multiplex), a 10% aqueous solution of D-mannitol (Nikken Fine Chemical Co., Ltd.)
sprayed as the spraying fluid and fluid bed granulation carried out. After 500g was
sprayed, it was dried and granulated mannitol was obtained (average particle diameter
150 to 220 urn).
In addition, using the same method, 500 g of erythritol (Mitsubishi Chemical
Corp.) was introduced into, a 10% aqueous solution of erythritol sprayed as the spray
fluid, fluid bed granulated, sprayed 500 g of the aqueous solution, after that dried, and
granulated erythritol obtained (average particle diameter 80 to 130 urn).
For the commercial sugar alcohol granules, direct tableting mannitol (Patikku
100M, Merck, granulated mannitol, average particle diameter 90 to 120 (m) was used
for the granulated substance.
[0031]
Crystal cellulose (Asahi Kasei Chemicals Corp., Seorasu PH301), crospovidon
XL10 (ISP), aspartame (Ajinomoto Co., Inc), magnesium stearate (Taihei Chemical
Industrial Co., Ltd.), crosscarmellose (Asahi Kasei Chemicals Corp.) and hydroxypropyl
starch (Fruend Industrial Co., Ltd.) were used as additives.
[0032]
The various compounds described above were tableted so as to have a diameter
of 7 mm with a weight of 100 mg per tablet in a rotary tableting machine according to
the recipe given in Table 1 through Table 3.
In addition, as a comparative example, an orally-disintegrating preparation was
tableted using only the powder sugar alcohol or only the granulated substance as

shown in Table 4.
[0033]

Table 1
Example 1 2 3 4 5 6 7 8 9 10
D-mannitol 37.5 45 50 37.5 45 50 56.3 37.5 45 50
Granulated Mannitol 37.5 30 25
Direct Tableting 37.5 30 25 18.7
Mannitol
Granulated Erythritol 37.5 30 25
Crystal Cellulose 13 13 13 13 13 13 13 13 13 13
Crospovidon 10 10 10 10 10 10 10 10 10 10
Aspartame 1 1 1 1 1 1 1 1 1 1
Magnesium Stearate 1 1 1 1 1 1 1 1 1 1
Tableting 450 700 850 450 650 800 950 500 750 900
Pressure (kgf/cm2)
Hardness (N) 40 40 35 40 45 35 30 40 40 30
Disintegration Time (s) 28 20 15 25 15 13 10 24 18 11
[0034]

Table 2
Example 11 12 13 14
D-mannitol 45 45 45 45
Direct Tableting Mannitol 30 30 30 30
Crystal Cellulose 13 13 13 8
Crospovidon 2 5
Crosscarmellose 5 5
Hydroxypropyl Starch 8 5 5 10
Aspartame 1 1 1 1
Magnesium Stearate 1 1 1 1
Tableting Pressure (kgf/cm2) 500 650 700 800
Hardness (N) 45 40 37 40
Disintegration Time (s) 25 19 27 24

[0035]

Table 3
Example 15 16 17 18
Acetaminophen 15
Risperidone 2
Zolpidem tartrate 10
Amlodipine Besilate 3.47
D-mannitol 36 39 45 43.53
Granulated Mannitol 24 26 28 28
Direct Tableting Mannitol 37.5
Granulated Erythritol
Crystal Cellulose 13 13 13 13
Crospovidon 10 10 10 10
Aspartame 1 1 1 1
Magnesium Stearate 1 1 1 1
Tableting Pressure (kgf/cm2) 800 750 650 650
Hardness (N) 35 40 45 40
Disintegration Time (s) 28 20 15 18
[0036]

Table 4
Comparative Example 1 2
D-mannitol 75
Granulated Mannitol
Direct Tableting Mannitol 75
Granulated Erythritol
Crystal Cellulose 13 13
Crospovidon 10 10
Aspartame 1 T—1
Magnesium Stearate 1 1
Tableting Pressure (kgf/cm2) 1000 600
Hardness (N) Tableting was 40
Disintegration Time (s) impossible 45
[0037]
From the results in Tables 1 through 4, the hardness was 30 N or greater for all
of the examples of the present invention, but even though it was high, the buccal cavity
disintegration time was within 30 sec, and a rapidly disintegrating orally-disintegrating

tablet was obtained. Moreover, all of the orally-disintegrating tablets in the examples
had a good feel on the tongue in the buccal cavity, and there was easy swallowing with
no feeling of roughness or sense of discomfort.
On the other hand, when only the powder sugar alcohol was used in the
comparative examples, tableting was impossible, and tablets could not be formed. In
addition, when only the granulated sugar alcohol was used, the buccal cavity
disintegration time increased.
[0038]
Regardless of the type of principal agent and regardless of the part that is
disintegrated, the present invention may be used over a wide range of formulations that
disintegrate and administer the agent.
This application claims priority to Japanese Patent Application No. 2007-103925.
The entire disclosure of Japanese Patent Application No. 2007-103925 is hereby
incorporated herein by reference.
While only selected embodiments have been chosen to illustrate the present
invention, it will be apparent to those skilled in the art from this disclosure that various
changes and modifications can be made herein without departing from the scope of the
invention as defined in the appended claims. Furthermore, the foregoing descriptions
of the embodiments according to the present invention are provided for illustration
only, and not for the purpose of limiting the invention as defined by the appended
claims and their equivalents. Thus, the scope of the invention is not limited to the
disclosed embodiments.

What is claimed is:
1. An orally-disintegrating tablet comprising a principal agent, a sugar alcohol
powder and a sugar alcohol granule, wherein the orally-disintegrating tablet has a
hardness of 30 N or greater.
2. The orally-disintegrating tablet according to claim 1, wherein the sugar
alcohol granule has a particle diameter of 2 to 20 times that of the sugar alcohol powder.
3. The orally-disintegrating tablet according to claim 1, wherein the sugar
alcohol powder is at least one compound selected from the group consisting of
D-mannitol, erythritol, sorbitol, xylitol.
4. The orally-disintegrating tablet according to claim 1, wherein the sugar
alcohol granule is formed by a wet granulation method.
5. The orally-disintegrating tablet according to claim 4, wherein the sugar
alcohol granule is formed by a method of agitating and granulating, fluid bed
granulating or spray drying.
6. The orally-disintegrating tablet according to claim 1, wherein the sugar
alcohol granule has a particle diameter of 80 m or more.
7. The orally-disintegrating tablet according to claim 1, wherein a mixture
ratio of the sugar alcohol powder and the sugar alcohol granule is of 8:1 to 1:4 by
weight of the total weight of the sugar alcohols.
8. The orally-disintegrating tablet according to claim 1, wherein an amount of
the sugar alcohol powder and the sugar alcohol granule is 50 % or more by weight of
the total weight of the orally-disintegrating tablet.
9. The orally-disintegrating tablet according to claim 1, further comprising at
least one compound selected from the group consisting of croscarmellose, sodium
starch glycolate, carmellose, starch, hydroxypropyl starch and crospovidone.
10. A manufacturing method for an orally-disintegrating tablet comprising:
mixing a sugar alcohol powder and a sugar alcohol granule with a principal
agent to obtain a mixture and
compression-molding the mixture at a hardness of 30 N or greater.

11. The method according to claim 10, wherein the mixing and
compression-molding are carried out without wetting and without addition of
moisture.

An orally-disintegrating tablet comprises a principal agent, a sugar alcohol powder and a sugar alcohol granule, wherein the orally-disintegrating tablet has a hardness of 30 N or greater. According to the present invention, a smooth swallowing orally-disintegrating tablet, for which both the mechanical strength and the
disintegration properties in the buccal cavity are favorable with using a normal tableting machine and without using special devices and the feeling on the tongue and taste are favorable, is provided.

Documents:

http://ipindiaonline.gov.in/patentsearch/GrantedSearch/viewdoc.aspx?id=GLFhNsvRDK2Jr5goBYgDGQ==&loc=wDBSZCsAt7zoiVrqcFJsRw==

« Previous Patent

Next Patent »

Patent Number

277135

Indian Patent Application Number

689/KOL/2008

PG Journal Number

47/2016

Publication Date

11-Nov-2016

Grant Date

11-Nov-2016

Date of Filing

08-Apr-2008

Name of Patentee

NIPRO CORPORATION

Applicant Address

9-3, HONJO-NISHI 3-CHOME, KITA-KU OSAKA-SHI, OSAKA

Inventors:

#	Inventor's Name	Inventor's Address
1	NAOHISA KATAYAMA	C/O. NIPRO CORPORATION, PHARMACEUTICAL RESEARCH CENTER 3023, NOJI-CHO, KUSATSU-SHI SHIGA-KEN 525-0055
2	TOSHIYA KAI	C/O. NIPRO CORPORATION, PHARMACEUTICAL RESEARCH CENTER 3023, NOJI-CHO, KUSATSU-SHI SHIGA-KEN 525-0055
3	SHIHO SAKURAGI	C/O. NIPRO CORPORATION, PHARMACEUTICAL RESEARCH CENTER 3023, NOJI-CHO, KUSATSU-SHI SHIGA-KEN 525-0055
4	JUN-ICHI YOKOE	C/O. NIPRO CORPORATION, PHARMACEUTICAL RESEARCH CENTER 3023, NOJI-CHO, KUSATSU-SHI SHIGA-KEN 525-0055

PCT International Classification Number

A61K9/20; A61K47/10

PCT International Application Number

N/A

PCT International Filing date

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1	2007-103925	2007-04-11	Japan