Title of Invention	SYNTHESIS OF NOW FLUCONAZOLE ANALOGUES CONTAINING 1,2,3-TRIAZOLE MOIETY AND HAVING BETTER ANTIFUNGAL SPECTRUM
Abstract	The need for new class of antifungal drugs with high efficacy and low toxicity is well established. Synthesis and antifungal activity of new analogues of the azole antifungal drug fluconazole, 1 -(1 H-1,2,4-triazol-1 -yl)-2-(2,4-difluorophenyl)-3-(4-substituted-1,2,3-triazol-1 -yl)-2-propanols of formula (1) and l-(lH-l,2,4-triazol-l-yl)-2-(2,4-difluorophenyl)-3-(N-substituted-l,2,3-triazol-4-yl)-2-propanols is described. These compounds were found to be less toxic than antifungal drug ketoconazole.

Title of Invention

SYNTHESIS OF NOW FLUCONAZOLE ANALOGUES CONTAINING 1,2,3-TRIAZOLE MOIETY AND HAVING BETTER ANTIFUNGAL SPECTRUM

Abstract

The need for new class of antifungal drugs with high efficacy and low toxicity is well established. Synthesis and antifungal activity of new analogues of the azole antifungal drug fluconazole, 1 -(1 H-1,2,4-triazol-1 -yl)-2-(2,4-difluorophenyl)-3-(4-substituted-1,2,3-triazol-1 -yl)-2-propanols of formula (1) and l-(lH-l,2,4-triazol-l-yl)-2-(2,4-difluorophenyl)-3-(N-substituted-l,2,3-triazol-4-yl)-2-propanols is described. These compounds were found to be less toxic than antifungal drug ketoconazole.

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Patent Number

278183

Indian Patent Application Number

771/DEL/2008

PG Journal Number

53/2016

Publication Date

23-Dec-2016

Grant Date

15-Dec-2016

Date of Filing

26-Mar-2008

Name of Patentee

COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

Applicant Address

ANUSANDHAN BHAWAN, RAFI MARG, NEW DELHI-110001, INDIA.

Inventors:

#	Inventor's Name	Inventor's Address
1	PRAVEEN KUMAR SHUKLA	CENTRAL DRUG RESEARCH INSTITUTE, CHATTAR MANZIL PALACE, POST BOX NO. 173, LUCKNOW 226001
2	NILKANTH GANPAT AHER	NATIONAL CHEMICAL LABORATORY, DR. HOMI BHABHA ROAD, PUNE-411008, INDIA.
3	VANDANA SUDHIR PORE	NATIONAL CHEMICAL LABORATORY, DR. HOMI BHABHA ROAD, PUNE-411008, INDIA.
4	MANOJ KUMAR BHAT	NATIONAL CENTRE FOR CELL SCIENCE, UNIVERSITY OF PUNE, CAMPUS, GANESHKHIND, PUNE 411007, INDIA.
5	GADDAM BALAKRISHNA SHIVA KESHAVA	CENTRAL DRUG RESEARCH INSTITUTE, CHATTAR MANZIL PALACE, POST BOX NO. 173, LUCKNOW 226001
6	AWANIT KUMAR	CENTRAL DRUG RESEARCH INSTITUTE, CHATTAR MANZIL PALACE, POST BOX NO. 173, LUCKNOW 226001
7	NRIPENDRA NATH MISHRA	CENTRAL DRUG RESEARCH INSTITUTE, CHATTAR MANZIL PALACE, POST BOX NO. 173, LUCKNOW 226001

PCT International Classification Number

C07D249/00

PCT International Application Number

N/A

PCT International Filing date

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1			NA