Title of Invention	“METHOD FOR PRODUCING PHAMACEUTICAL COMPOSITION
Abstract	There have been demands for a pharmaceutical composition which has good dissolvability and contains a compound represented by formula (I) a pharmaceutically acceptable salt thereof or a solvate of the compound or salt and which has an inhibitory effect on activated blood coagulation factor X and is useful as a prophylactic and/or therapeutic agent for thrombotic diseases. Disclosed is a method for producing a pharmaceutical composition that contains a compound represented by formula (I) which comprises a step wherein a compound represented by formula (I) a pharmaceutically acceptable salt thereof or a solvate of the compound or salt one or more excipients selected from the group consisting of sugar alcohols and water-swellable additives a disintegrant and a binder are mixed under such conditions that the maximum water content in a granulated product is maintained at 10% or less during the granulation.

Title of Invention

“METHOD FOR PRODUCING PHAMACEUTICAL COMPOSITION

Abstract

There have been demands for a pharmaceutical composition which has good dissolvability and contains a compound represented by formula (I) a pharmaceutically acceptable salt thereof or a solvate of the compound or salt and which has an inhibitory effect on activated blood coagulation factor X and is useful as a prophylactic and/or therapeutic agent for thrombotic diseases. Disclosed is a method for producing a pharmaceutical composition that contains a compound represented by formula (I) which comprises a step wherein a compound represented by formula (I) a pharmaceutically acceptable salt thereof or a solvate of the compound or salt one or more excipients selected from the group consisting of sugar alcohols and water-swellable additives a disintegrant and a binder are mixed under such conditions that the maximum water content in a granulated product is maintained at 10% or less during the granulation.

Full Text	PLEASE SEE THE SPECIFICATION ATTACHED.

Documents:

http://ipindiaonline.gov.in/patentsearch/GrantedSearch/viewdoc.aspx?id=OrE/6X16xBnpkuAwMFxSnQ==&loc=vsnutRQWHdTHa1EUofPtPQ==

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Patent Number

279488

Indian Patent Application Number

1865/MUMNP/2012

PG Journal Number

04/2017

Publication Date

27-Jan-2017

Grant Date

24-Jan-2017

Date of Filing

30-Jul-2012

Name of Patentee

Daiichi Sankyo Company Limited

Applicant Address

3-5-1 Nihonbashi Honcho Chuo-ku Tokyo 103-8426 Japan.

Inventors:

#	Inventor's Name	Inventor's Address
1	KAMADA Makoto	c/o Daiichi Sankyo Limited 1-12-1 Shinomiya Hiratsuka-shi Kanagawa 254-0014 Japan.
2	SEKIGUCHI Gaku	c/o Daiichi Sankyo Limited 1-12-1 Shinomiya Hiratsuka-shi Kanagawa 254-0014 Japan.
3	KIDOKORO Motonori	c/o Daiichi Sankyo Limited 1-12-1 Shinomiya Hiratsuka-shi Kanagawa 254-0014 Japan.

PCT International Classification Number

A61K 31/444

PCT International Application Number

PCT/JP2011/055956

PCT International Filing date

2011-03-14

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1	2010-063694	2010-03-19	Japan