| Title of Invention | "PROLYL HYDROXYLASE INHIBITORS" |
|---|---|
| Abstract | The invention described herein relates to certain pyrimidinetrione N-substituted glycine derivatives of formula (I), (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example. |
| Full Text | Prolyl Hydroxylase Inhibitors FIELD OF THE INVENTION This invention relates to certain heteroaromatic N-substituted glycine derivatives that are inhibitors of HIF prolyl hydroxylases, and thus have use in treating diseases benefiting from the inhibition of this enzyme, anemia being one example BACKGROUND OF THE INVENTION Anemia occurs when there is a decrease or abnormality in red blood cells, which leads to reduced oxygen levels in the blood Anemia occurs often in cancer patients, particularly those receiving chemotherapy. Anemia is often seen in the elderly population, patients with renal disease, and m a wide variety of conditions associated with chronic disease. Frequently, the cause of anemia is reduced erythropoietin (Epo) production resulting in prevention of erythropoiesis (maturation of red blood cells) Epo production can be increased by inhibition of prolyl hydroxylases that regulate hypoxia inducible factor (HIF) One strategy to increase erythropoietin (Epo) production is to stabilize and thus increase the transcriptional activity of the HIF HIF-alpha subunits (HIF -1 alpha, HIF-2alpha, and HIF -3alpha) are rapidly degraded by proteosome under normoxic conditions upon hydroxylation of proline residues by prolyl hydroxylases (EGLN1, 2, 3) Proline hydroxylation allows interaction with the von Hippel Lindau (VHL) protein, a component of an E3 ubiquitm ligase This leads to ubiquitination of HIF-alpha and subsequent degradation Under hypoxic conditions, the inhibitory activity of the prolyl hydroxylases is suppressed, HIF-alpha subunits are therefore stabilized, and HIF-responsive genes, including Epo, are transcribed. Thus, inhibition of prolyl hydroxylases results m increased levels of HIF-alpha and thus increased Epo production The compounds of this invention provide a means for inhibiting these hydrolases, increasing Epo production, and thereby treating anemia Ischemia, myocardial infarction, stroke, and cytoprotection may also benefit by administering these compounds SUMMARY OF THE INVENTION In the first instance, this invention relates to a compound of formula (I) (Formula Removed) wherein R1 and R4 are each independently selected from the group consisting of hydrogen, -NR5R5, C1-C10alkyl, C2-C10alkenyl, C2-C10alkynyl, C3-C8cycloalkyl, C3-C8cycloalkyl-C1-C10alkyl, C5-C8cycloalkenyl, C5-C8cycloalkenyl-C1-C10alkyl, C3-C8heterocycloalkyl, C3-C8heterocycloalkyl- C1-C10alkyl, aryl, aryl-C1-C10alkyl, heteroaryl and heteroaryl-C1-C10alkyl, R2 is ~NR7R8 or -OR9, R3 is H or C1-C4alkyl, where R5 and R6are each independently selected from the group consisting of hydrogen, C1-C10alkyl, C3-C8cycloalkyl, C3-C8cycloalkyl-C1-C10alkyl, C3-C8heterocycloalkyl, C3-C8heterocycloalkyl-C1-C10alkyl, aryl, aryl-C1-C10alkyl, heteroaryl, heteroaryl-C1-C10alkyl, -C(O)C1-C4alkyl, -C(O)C3-C6cycloalkyl, -C(O)C3-C6heterocycloalkyl, -C(O)aryl, -C(O)heteroaryl and -S(O)2CrC4alkyl. or, when Rs and R6 are attached to the same nitrogen, R5 and R6 taken together with the nitrogen to which they are attached form a 5- or 6- or 7-membered saturated ring optionally containing one other heteroatom selected from oxygen, nitrogen and sulphur, R7 and R8 are each independently selected from the group consisting of hydrogen, C1-C10alkyl, C2-C10alkenyl, C2-C10alkynyl, C3-C8cyeloalkyl, C3-C8heterocycloalkyl, aryl and heteroaryl, and R9 is H or a cation, or C1-C10alkyl which is unsubstituted or substituted with one or more substituents, suitably from 1 to 6 substituents, suitably from 1 to 3 substituents, independently selected from the group consisting of C3-C6cycloalkyl, heterocycloalkyl, aryl and heteroaryl, X is O or S, and YisOorS, where any carbon or heteroatom of R1, R2, RJ, R4, R5, R5', R7, R8, R9 is unsubstituted or, where possible, is substituted with one or more substituents, suitably from 1 to 6 substituents, suitably from 1 to 3 substituents, independently selected from C1-C6alkyl, C1-C8haloalkyl, halogen, -OR10, -NR5R6, oxo, cyano, mtro, -C(O)R10, -C(O)OR10, -SR10, -S(O)R10, -S(O)2R'°, -NR5R6, -CONR5R6, -N(Rs)C(O)R10, -N(R5)C(O)0R10, -0C(O)NR5R6, -N(R5)C(O)NR5R6, -SO2NR5R6, -N(R5)SO2R10, C2-C10alkenyl, C2-C10alkynyl, C3-C6cycloalkyl, C3-C6heterocycloalkyl, aryl, C3-C6alkyl-aryl, heteroaryl and C1-C6alkyl-heteroaryl, wherein R5 and R6 are the same as defined above and R'° is selected from hydrogen, C1-C10alkyl, C2-C10alkenyl, C2-C10alkynyl, -C(O)C1-C4alkyl, -C(O)aryl, -C(O)heteroaryl, -C(O)C3-C6cycloalkyl, -C(O)C3-C6heterocycloalkyl, -S(O)2C1-C4-alkyl, C3-C8cycloalkyl, C3-C8heterocycloalkyl, C6-C14aryl, aryl-C1-C10alkyl, heteroaryl and heteroaryl-C1-C10alkyl, and/or a pharmaceutically acceptable salt or solvate thereof. In a second aspect of the present invention, there is provided a compound of formula (I) and/or a pharmaceutically acceptable salt or solvate thereof for use in mammalian therapy, including human therapy, e.g. treating amenia An example of this therapeutic approach is that of a method for treating anemia which is effected by increasing the production of erythropoietin (Epo) by inhibiting HIF prolyl hydroxylases comprising administering a compound of formula (I) and/or a pharmaceutically acceptable salt or solvate thereof, to a patient m need thereof, neat or admixed with a pharmaceutically acceptable excipient or excipients, in an amount sufficient to increase production of Epo. In a third aspect of the present invention, there is provided a pharmaceutical composition comprising a compound of formula (I), and/or a pharmaceutically acceptable salt or solvate thereof, and one or more of pharmaceutically acceptable earners, diluents and excipients In a fourth aspect, there is provided the use of a compound of formula (I) and/or a pharmaceutically acceptable salt or solvate thereof, in the preparation of a medicament for use in the treatment of a disorder mediated by inhibiting HIF prolyl hydroxylases, such as an anemia, that can be treated by inhibiting HIF prolyl hydroxylases In a fifth aspect, there is provided methods of co-administering the presently invented compounds of formula (I) with further active ingredients DETAILED DESCRIPTION OF THE INVENTION For the avoidance of doubt, unless otherwise indicated, the term "substituted" means substituted by one or more defined groups In the case where groups may be selected from a number of alternative groups the selected groups may be the same or different The term "independently" means that where more than one substituent is selected from a number of possible substituents, those substituents may be the same or different An "effective amount" means that amount of a drug or pharmaceutical agent that will elicit the biological or medical response of a tissue, system, animal or human that is being sought, for instance, by a researcher or clinician Furthermore, the term "therapeutically effective amount" means any amount which, as compared to a corresponding subject who has not received such amount, results in improved treatment, healing, prevention, or amelioration of a disease, disorder, or side effect, or a decrease in the rate of advancement of a disease or disorder. The term also includes within its scope amounts effective to enhance normal physiological function As used herein the term "alkyl" refers to a straight- or branched-cham hydrocarbon radical having the specified number of carbon atoms, so for example, as used herein, the terms "CiX^alkyl" and "C1-C10 alkyl" refers to an alkyl group having at least 1 and up to 4 or 10 carbon atoms respectively. Examples of such branched or straight-chained alkyl groups useful m the present invention include, but are not limited to, methyl, ethyl, n-propyl, isopropyl, isobutyl, n-butyl, t-butyl, n-pentyl, isopentyl, n-hexyl, n-hepryl, n-octyl, n-nonyl, and n-decyl, and branched analogs of the latter 5 normal alkanes When the term "alkenyl" for "alkenylenc") is used it refers to straight or branched hydrocarbon chains containing the specified number of carbon atoms and at least 1 and up to 5 carbon-carbon double bonds. Examples include ethenyl (or ethenylene) and propenyl (or propenylene) When the term "alkynyl" (or "alkynylene") is used it refers to straight or branched hydrocarbon chains containing the specified number of carbon atoms and at least 1 and up to 5 carbon-carbon triple bonds. Examples include ethynyl (or ethynylene) and propynyl (or propynylene) "Haloalkyl" refers to an alkyl group group that is substituted with one or more halo substituents, suitably from 1 to 6 substituents Haloalkyl includes trifluoromethyl When "cycloalkyl" is used it refers to a non-aromatic, saturated, cyclic hydrocarbon nng containing the specified number of carbon atoms So, for example, the term "Cs-Cscycloalkyl" refers to a non-aromatic cyclic hydrocarbon ring having from three to eight carbon atoms Exemplary "C3-C8cycloalkyl" groups useful in the present invention include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclohepryl and cyclooctyl The term "C5-C8cycloalkenyl" refers to a non-aromatic monocyclic carboxycychc nng having the specified number of carbon atoms and up to 3 carbon-carbon double bonds. "Cycloalkenyl" includes by way of example cyclopentenyl and cyclohexenyl Where "C3-C8heterocycloalkyl" is used, it means a non-aromatic heterocyclic nng containing the specified number of nng atoms being, saturated or having one or more degrees of unsaturation and containing one or more heteroatom substitutions independently selected from O, S and N Such a ring may be optionally fused to one or more other "heterocyclic" ring(s) or cycloalkyl ring(s). Examples of "heterocyclic" moieties mclude. but are not limited to, azindme, thiirane, oxirane, azetidme, oxetane, thietane, tetrahydrofuran, pyran, 1,4-dioxane, 1,3-dioxane, piperidme, piperazme, 2,4-piperazinedione, pyrrolidine, lmidazohdine, pyrazohdine, morpholine, thiomorpholme, tetrahydrothiopyran, tetrahydrothiophene, and the like. "Aryl" refers to optionally substituted monocyclic and polycarbocychc unfused or fused groups having 6 to 14 carbon atoms and having at least one aromatic rmg that complies with Huckel's Rule. Examples of aryl groups are phenyl, biphenyl, naphthyl, anthracenyl, phenanthrenyl and the like "Heteroaryl" means an optionally substituted aromatic monocyclic nng or polycarbocychc fused nng system wherein at least one nng complies with Huckel's Rule, has the specified number of ring atoms, and that nng contains at least one heteratom independently selected from N, O and S Examples of "heteroaryl" groups include furanyl, thiophenyl, pyrrolyl, lmidazolyl, pyrazolyl, tnazolyl, tetrazolyl, thiazolyl, oxazolyl, isoxazolyl, oxadiazolyl, oxo-pyridyl, thiadiazolyl, isothiazolyl, pyridinyl, pyridazmyl, pyrazmyl, pynmidmyl, quinolinyl, isoqumolinyl, benzofuranyl, benzothiophenyl, indolyl and indazolyl The term "optionally" means that the subsequently descnbed event(s) may or may not occur, and includes both event(s), which occur, and events that do not occur The term "solvate" refers to a complex of variable stoichiometry formed by a solute and a solvent Such solvents for the purpose of the invention may not interfere with the biological activity of the solute. Examples of suitable solvents include, but are not limited to, water, methanol, ethanol and acetic acid. Preferably the solvent used is a pharmaceutical^/ acceptable solvent Examples of suitable pharmaceutically acceptable solvents include, without limitation, water, ethanol and acetic acid. Most preferably the solvent used is water Herein, the term "pharmaceutically-acceptable salts" refers to salts that retain the desired biological activity of the subject compound and exhibit minimal undesired toxicological effects These pharmaceutically-acceptable salts may be prepared in situ dunng the final isolation and purification of the compound, or by separately reacting the punfied compound m its free acid or free base form with a suitable base or acid, respectively By the term "co-adrmnistering" and denvatives thereof as used herein is meant eithei simultaneous administration or any manner of separate sequential administration of a prolyl hydroxylase inhibiting compound, as descnbed herein, and a further active ingredient or ingredients, known to be useful m treating diseases of the hematopoietic system, particularly anemias, including EPO or a denvative thereof. The term further active ingredient or ingredients, as used herein, includes any compound or therapeutic agent known to or that demonstrates advantageous properties when administered to a patient in need of treatment for diseases of the hematopoietic system, particularly anemias or any compound known to be useful when used in combination with a prolyl hydroxylase inhibiting compound Preferably, if the administration is not simultaneous, the compounds are administered in a close time proximity to each other Furthermore, it does not matter if the compounds are administered in the same dosage form, e.g one compound may be administered topically and another compound may be administered orally In certain embodiments, compounds according to Formula I may contain an acidic functional group, one acidic enough to form salts Representative salts include pharmaceutically-acceptable metal salts such as sodium, potassium, lithium, calcium, magnesium, aluminum, and zinc salts; carbonates and bicarbonates of a pharmaceutically-acceptable metal cation such as sodium, potassium, lithium, calcium, magnesium, aluminum, and zinc, pharmaceutically-acceptable organic pnmary, secondary, and tertiary amines including aliphatic amines, aromatic amines, aliphatic diamines, and hydroxy alkylammes such as methylamine, ethylamme, 2-hydroxyethylamine, diethylamine, tnethylamine, ethylencdiamiiie. ethanolamine. diethanolamme, and cyclohexylamine In certain embodiments, compounds according to Formula (I) may contain a basic functional group and are therefore capable of forming pharmaceutical^-acceptable acid addition salts by treatment with a suitable acid Suitable acids include pharmaceutically-acceptable inorganic acids and pharmaceutically-acceptable organic acids Representative pharmaceutieally-acceptable acid addition salts include hydrochloride, hydrobromide, nitrate, methybiitrate, sulfate, bisulfate, sulfamate, phosphate^ acetate, hydroxyacetate. phenylacetate, propionate, butyrate, isobutyrate, valerate, maleate, hydroxymaleate, acryldte, fumarate, malate, tartrate, citrate, salicylate,/3-aminosalicyclate, glycollate, lactate, heptanoate, phthalate, oxalate, succinate, benzoate, o-acetoxybenzoate, chlorobenzoate. methylbenzoate, dinitrobenzoate, hydroxy benzoate, methoxybenzoate, mandelate, tannate, formate, stearate, ascorbate, palmitaie, oleate, pyruvate, pamoate, malonate, laurate, glutarate, glutamate, estolate, methancsulfonate (mesylate), ethanesulfonate (esylate), 2-hydroxyethanesulfonate, benzenesulfonate (besylate), p~ aminobenzenesulfonate,/>-toluenesulfonate (tosylate) and napthalene-2-sulfonate Compounds of formula (1) that are of particular interest include those wherein X is O, Yis O. R1 and R4 are each independently selected from the group consisting of hydrogen, C1-C10alkyl, C2-C10alkenyl, C2-C10alkynyl, C3-C8eycloalkyl, C1-C8cycioaikyl-C1-C10alkyl. C5-C8cycloalkenyl, C5-C8Cycloalkenyl-C1-C10alkyl, C3-C8heteroc\cloalkyl, C3-C8heterocycloalkyl-C1-C10alkyl, aryl, aryl-C1-C10alkyl, heteroaryl and heteroaryl-C1-C10alkyl; R2 is -NR7R8 or -OR9; R3 is H or C1-C4alkyll, where R7 and R8 are each independently selected from the group consisting of hydrogen, C1-C10alkyl, C2-C10alkenyl, C2-C10alkynyl, C3-C8cycloalky 1. C3-C8heteroeycloalkyl, aryl and heteroaryl, and R9 is H or a cation, or C1-C10alkyl which is unsubstituted or substituted with one or more substituents, suitably from 1 to 6 substituents, suitably from 1 to 3 substituents, independently selected from the group consisting of C3-C8cyeloalkyl, heterocycloalkyl, aryl and heteroaryl, where any carbon or heteroatom of R1, R2, R3,R4, R5, R6, R8 is unsubstituted or, where possible, is substituted with one or more substituents, suitably from 1 to ft substituents, suitably from 1 to 3 substituents, independently selected from C1-C6alkyl. C1-C6haloalkyl, halogen, -OR10, -NR5R6, oxo, cyano, nitro. -C(O)R10. -C(O)OR10, -SR10, -S(O)R10. -S(O)2R10, -NR5R6, -CONR5R°, -N(R5)C(O)R10, -N(R5)C(O)OR10, -OC(O)NR5R6, -N(R5)C(O)NR5R6, -SO2NR5Rb, ~N(R5)SO2R °. C2-C10alkenyl. C2-C10alkynyl, C3-C6cycloalkyl, C3-C6heterocycloalkyl, aryl, C1-C6alkyl-aryl, heteroaryl and C3-C6alkyl-heteroaryl, wherein R5, and R6 are the same as defined above and R'° is selected from hydrogen, C1-C10alkyl, C2-C10alkenyl, C2-C10alkynyl, -C(O)C1-C2 alkyl, -C(O)aryl, -C(O)heteroaryl, -C(O)C3-Cseycloalkyl, -C(O)C3-C6heterocytloalkyl, ~S(O)2C1-C4 alkyl, C3-C8cycloalkyl, C5-C8heterocycloalkyl. C6-C+14aiyl, aryl-C1-C10aikyl, heteroaryl and heteroaryl-C1-C10alkyl, and/or a pharmaceutically acceptable salt or solvate thereof Compounds of formula (1) that are of further interest are those wherein X is O, Y is 0; R1 and R4 are each independently selected from the group consisting of hydrogen, C1-C10alkyi, C2-C10alkenyl, C2-C10alkynyl, C3-C8eycloalkyi, C3-C8cycloalkyl-C1-C10alkyl, C5-C8cycloalkenyl, C5-C8cycloalkenyl-C1-C10alkyl, C3-C8eterocycloalkyl, C3-C8heterocycloalkyl-C1-C10alkyl, aryl, aryl-C1-C10alkyl, heteroaryl andheteroaryl-C1-C10alkyl. R- is -OR9. R3 is H or C1-C4alkyl, R8is II or a cation, or C1-C10alkyi which is unsubstituted or is substituted with one or more substituents, suitably from 1 to 6 substituents. suitably from 1 to 3 substituents, independently selected from the group consisting of Cj-C6 cycloaikyl, heterocycloalkyl. aryl and heteroaryl; where any carbon or heteroatom of R1, R2, R3, R4, R9 IS unsubstituted or. where possible, is substituted with one or more substituents, suitably from 1 to 6 substituents, suitably from 1 to 3 substituents, independently selected from C3-C6alkyi, C1-C6,hdloalkyl, halogen, -OR10, -NR5R6, oxo, cyano, nitro, -C(O)R10. -C(O)OR10 -SR10, -S(O)R10, -S(O)2R10, ~NR5R6. -CONR5R6, -N(R5)C(O)R10, -N(R5)C(O)ORl0, -OC(O)NR5R6, -N(R5)C(O)NRsR6, -SO2NR5R6, -N(R5)SO2R10, C2-C10 alkenyl, C2-C10 alkynyl. C3-C6cycloalkyt, C3-C6heterocycloalkyl, aryl, C1-C6alkyl-aryl, heteroaryl and C3-C6 alkyl-heteroaryl, wherein R5, and Rs are the same as defined above and R'° is selected from hydrogen, C1-C10alkyl, C2-C10alkenyl, C2-Cl0alkynyl, -C(O)C1-C4alkyl, -C(O)aryl, -C(O)heteroaiyl, -C(O)C3-C6cycloalkyl, -C(O)C3-C6heterocycloalkyl, -S(O)2C1-C4alkyl, C3-C8cycloalky!, C3-C8heterocycloalkyl, C6-Cl4aryl, aryl-C1-Cl0alkyl, heteroaryl and heteroaryl-C4-C10alkyl; and/or a pharmaceutically acceptable salt or solvate thereof Of further interest are those compounds of formula (1) where X is O, Y is O, R1 and R4 are each independently selected from the group consisting of hydrogen, C1-C10alkyl, C2-C10alkenyl, C2-C10alkynyl, C3-C8cycloalkyl, C3-C8cycloalkyl-C1-C10alkyl, C5-C8cycloalkenyl, C5-C8CycloalkenyI-C1-C10alkyl, C3-C8heterocycloalkyl, C3-C8heterocycloalkyl-C1-C10alkyl, aryl, aryl-Ct.Cioalkyl, heteroaryl and heteroaryl-C1-C10alkyl, R2 is -OR9, R3 is H, R9 is H or a cation, where any carbon or heteroatom of R1, R\ R\ R* is unsubstituted 01, where possible, is substituted with one or more substituents, suitably from 1 to 6 substituents, suitably from 1 to 3 substituents, independently selected from C1-C6dlkyl, C 1-C6haloalky1, halogen, -OR10, -NR5R6, oxo, cyano, mtro, -C(O)R10. -C(O)OR10, -SR10 -S(O)Rl0. ~S(O)2R10, -NR5R6, -CONR5R6, -N(R5)C(O)R10, -N(R')C(O)OR10, -OC(O)NR5R6, -N(R5)C(O)NR5R6, -SO2NR5R6, -N(R5)SO2R10, C2-C,oalkenyl, C2-C10alkynyl, C3,-C6cycloalkyl, C3-C6heterocycloalkyl, aryl, C1-C6alkyl-aryl, heteroaryl and C1-C6 alkyl-heteroaryl, wherein R5, and R6 are the same as defined above and R ° is selected from hydrogen, C1-C10alkyl, C2-C10alkenyl, C2-C10alkynyl, -C(O)C1-C4alkyl, -C(O)aryl, -C(O)heteroaryl, -C(O)C3-C6cycloalkyl, -C(O)C3-C6heterocycloaLkyl, -S(O)2C1-C4 alkyl, C3-C8 cycloalkyl, C3-C8heterocycloalkyl, C6-C+14 aryl, aryl-CVCjoalkyl, heteroaryl and heteroaryl-C1-C10alkyl, and/or a pharmaceutically acceptable salt or solvate thereof Specific compounds that arc exemplified herein and that are useful in the present mvention are N-{[l-(4-chIorophenyl)-6-hydroxy-2,4-dioxo-3-(phenylmethyl)-l,2,3,4-tetrahydro-5-pyrimidinyl]carbony 1} glycine, N-{[l-{[2,4-bis(methyloxy)phenyl]methyl}-6-hydroxy-2,4-dioxo-3-(phenylmethyl)-l,2,3,4-tetrahydro-5-pyrimidmyl]carbonyl} glycine, N- {[l-(4-chlorophenyl)-6-hydroxy-4-oxo-3-(phenylmethyl)-2-thioxo-1,2,3,4-tetrahydro-5-pynmidmyljcarbonyl} glycine, N-({6-hydroxy-2,4-dioxo-3-(phenylmethyl)-l-[3-(tnfluoromethyl)phenyl]-l,2,3,4-tetrahydro-5-pyrimidinyl}carbonyl)glycme, N-{[6-hydroxy-2,4-dioxo-3-(phenylmethyl)-l,2,3,4-tetrahydro 5-pyrimidinyl]carbony 1} glycine, N-{[6-hydroxy-2,4-dioxo-l-phenyl-3-(phenylmethyl)-l,2,3,4-tetrahydro~5-pyrimidinyl]carbonyl} glycine, N-[( 1 -(1, l-dimethylethyl)-3- {[4-( 1,1 -dimethy lethyl)phenyl]methy 1} -6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidmyl)carbonul]glycine, N- {[6-Hydroxy-2,4-dioxo-3-(phenylmethyl)-1 -(2-pyridmyl)-1,2,3,4-tetrahydro-5-pyrimidinyljcarbonyl} glycine, N-{[6-Hydroxy-l-(2-rutrophenyl)-2.4-dioxo-3-(phenylmethyl)-l,2 3,4-tetrahydro-5 pyrimidinyl]carbonyl} glycine, N-{[l-Cyclohexyl-6-hydroxy-2,4-dioxo-3-(phenylmethyl)-l,2,3,4-tetrahydro-5-pynmidmyl]carbonyl} glycine. N- {[l-[(3-Cyanophenyl)methyl]-6-hydroxy-2.4-dioxo-3~(phenylmethyl)-1,2,3,4-tetrahydro-5-pynmidinyl]carbonyl}glycine, N-[(6-Hydroxy-2,4-dioxo-3-(phenylmethyl)-l-{[4-(tnfluoromethyl)phenyl]methyl]-l,2,3,4-tetrahydro-5-pyrimidmyl)carbonyl]glycme, N-{[l-[(3,4-Dichlorophenyl)methylJ-6-hydroxy-2,4-dioxo-3-(phenylmethyl)-1,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine, N-{[6-Hydroxy-l-{[3-(methyloxy)phenyl]methyl}-2,4-dioxo-3-(phenylmethyl)-l,2,3,4-tetrahydro-5-pynmidinyl]carbonyl}glycine, N-{[l-[(2,6-Dichlorophenyl)methyl]-6-hydroxy-2,4-dioxo-3-(phenylmethyl)-l,2,3,4-tetrahy dro-5 -pyrimidiny l]carbonyl} glycine, N- {[6-Hydroxy-1 -methyl-2,4-dioxo-3-(phenylmethyl)-1,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine: N-{[l-Cyclohexyl-3-(2-cyclopropylethyl)-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pynmidinyl]carbonyl} glycine, N-[(l,3-Dicyclohexyl-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pynmidinyl)carbonylJglycine, N-{[l-Hexyl-6-hydroxy-2,4-dioxo-3-(phenylmethyl)-l,2,3,4-tetrahydro-5-pyrimidinyl]cait>onyl} glycine, N-{[l-Ethyl-6-hydroxy-2,4-dioxo-3-(phenylmethyl)-l,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl}g]ycine, N-{[6-Hydroxy-2,4-dioxo-3-(phenylmethyl)-l-propyl-l,2,3,4-tetrahydro-5-pynmidinyl]carbonyl}glycine, N-{[l-Butyl-6-hydroxy-2,4-dioxo-3-(phenylmethyl)-l,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine, N- {[6-Hydroxy-2,4-dioxo-1 -(2-phenylethyl)-3-(phenylmethyl)-1,2,3,4-tetrahydro-5-pyrimidinyljcarbonyl} glycine; N- {[3- {[4-( 1,1 -Dunethylethyl)phenyl]methyl} -6-hydroxy-1 -(1 -methylethyl)-2,4-dioxo-1,2,3,4-tetrahydro-5-pynmidinyl]carbonyl} glycine, N-[(l -cyclohexyl-3- {[4-( 1,1 -dimethy]ethyl)phenyl]methyl} -6-hydroxy-2,4-dioxo~ 1,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycme, N-{[6-Hydroxy-l,3-bis(l-methylethyl)-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine, N- {[3-[(2-Bromophenyl)methyl]-1 -(1,1 -dimethylethyl)-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pynmidmyl]carbonyl} glycine, N-[(1 -(2,6-Dichlorophenyl)-3- {[4-( 1,1 -dimethylethyl)phenyl]methyl) -6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pynmidmyl)carbonyl]glycine, N-[( 1 -(2,4-dichlorophenyl)-3- {[4-( 1,1 -dimethy lethyl)phenyl]methyl} -6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pynmidmyl)carbonyl]glycme, N-[(1 -(2-Bromophenyl)-3- {[4-( 1,1 -dimethy lethyl)phenyl]methyl}-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pynmidmyl)carbonyl]glycine, N-[( 1 -(2-Biphenylyl)-3- {[4-( 1,1 -dimethylethyl)phenyl]methyl} -6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pynmidmyl)carbonyl]glycine, N- {[6-Hydroxy-2,4-dioxo-3-(phenylmethyl)-1 -(tetrahydro-2H-pyran-4~yl)-1,2,3,4-tetrahydro-5-pynmidinyl]carbonyl} glycine. N- {[3-Cyclohexyl-6-hydroxy-2,4-dioxo-1 -(tetrahydro-2H-pyran-4-yl)-1,2,3,4-tetrahydro-5-pynmidinyl]carbonyl} glycine; N-{[3- {[4-( 1,1 -Dimethylethyl)phenyl]methy 1} -6-hydroxy-2,4-dioxo-1 -(2-thienyl)-1,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl}glycme. N-({l-Cyclohexyl-6-hydroxy-3-[3-(4-morpholmyl)propyl]-2,4-dioxo-l, 2,3,4- tetrahydro-5-pyrimidmyl} carbonyl)glycine, N~{[3- {[4-(l,l -Dimethylethyl)phenyl]methyl} -6-hydroxy-2,4-dioxo-1 -(3-pyridmyl)-1,2,3,4--tetrahydro-5-pyrimidmyljcarbonylJglycme. N-({l-Cyclohexyl-3-fC2-fluorophenyl)methyl]-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidmyl} carbonyl)glycine. N-({3-[(2-Chlorophenyl)methyl]-l-cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl}carbonyl)glycine; N-({l-Cyclohexyl-6-hydroxy-2,4-dioxo-3-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)methyl]-l,2,3,4-tetrahydro-5-pynmidmyl}carbonyl)glycine, N-({]-Cyclohexyl-3-[(2,4-dimethylphenyl)methyl]-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pynmidinyl}carbonyl)glycme. N-( {1 -Cyclohexyl-6-hydroxy-2,4-dioxo- 3- [(2,4,6-trifluorophenyl)methyl]-1,2,3,4-tetrahydro-5-pynmidmyl}carbonyl)glycine. N-[(l-Cyclohexyl-6-hydroxy-3-{[4-(J-methylethyl)phenyl]methyl)-2,4-dioxo-l,2,3,4-tetrahydro-5-pynmidinyl)carbonyl]glycme, N-( {1 -Cyclohexyl-3-[(2-ethylphenyl)methyl]-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidmyl}carbonyl)glycine, N-( {1 -Cyclohexyl-3-[(4-ethylphenyl)mcthyl]-6-hydioxy-2,4-dio\o -1,2,3,4-tetrahydro-5-pynmidinyl}carbonyl)glycme, N-( {]-Cyclohexyl-6-hydroxy-2,4-dioxo-3-[(2,4,6-tnmethylphenyl)methyl]-1,2,3,4-tetrahydro-5 -pyrmiidinyl} carbony l)glycme, N- {[1 -Cyclohexyl-3-(2-cyclohexylethyl)-6-hydroxy -2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidiny l]c arbony 1} glycine, N-[(3-{[3,5-Bis(methyloxy)phenyl]methyl'|-l -cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycme, N-{[l-Cyclohexyl-6-hydroxy-3-(2-naphthalenylmethyl)-2,4-dioxo-l,2,3,4-1etrahydro-5-pynmidmyl]carbonyl} glycine, N-( {1 -Cyclohexyl-6-hydroxy-3-[(4-methylphenyl)methyl]-2,4-dioxo-1,2,3,4-tetrahydro-5-pynmidmyl} carbony l)glycine, N-{t3-(4-Biphenylylmethyl)-l-cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidmyl]carbonyl}glycine, N-[(3-{[4-(l,3-Benzoxazol-2-yl)phenyl]methyl}-l-cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidmyl)carbonyl]glycme, N-({3-[2-(4-Biphenylyl)-2-oxoethyl]-l -cyclohexyl-6-hydroxy-2.4-dioxo-1,2,3,4-tetrahydro-5-pynmidmyl}carbonyl)glycme, N-[(l,3-Bis{[4-(l,l-dimethylethyl)phenyl]methyH-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycme. N-{fl-Cyclohexyl-6-hydroxy-3-(4-methylcycloheKyl)-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine, N-({ l-Cyclohexyl-3-[4-(l,l-dimethylethyl)cyclohexyl]-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahy dro-5 -pyrunidmyl} carbonyl )gly cme, N-[(l-Cyclohexyl-6-hydroxy-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydro-5-pynmidmyl)carbonyl] glycine, N-({l-Cyclohexyl-3-[4-(l,l-diinethylethyl)phenylJ-6-hydroxy-2,4-dioxo-],2,3,4-tetrahydro-5-pyrinudinyl}carbonyl)glycine, N-{[l-Cyclohexyl-3-(cyclohexylmethyl)-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyljcarbonyl} glycine; N-[(3-Cycloheptyl-l-cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyriimdinyl)carbonyl]glycme, N-[(3-Cyclohexyl-6-hydroxy-2,4-dioxo-l-tncyclo[3 3.1 l,7]dec l-yl-l,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycine, N-({1 -[(lR,2RAS)-Bicyclo[2 2 1 ]hept-2-yl]-3-cyclohexyi-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahy dro-5-pynmidinyl} carbony l)gly cine, N-{[l-Cyclohexyl-6-hydroxy-3-(3-methylcyclohexyl)-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidmy l]carbonyl} glycine; N-[(3-Cyclohexyl-l-cyclopropyl-6-hydro\y-2,4-dioxo-l,2,3,4-tetrahydro-5-pynmidinyl)earbonyl]glycine, N-[(l-Cyclobutyl-3-cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,44etrahydro-> pyrimidinyl)carbonyl]glycine, yV-[(3-Cyclohexyl-l-cyclopentyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pynmidinyl)carbonyl]glycme, N-{[6-Hydroxy-l,3-bis(3-methylbutyl)-2,4-dioxo-K2,3,4-tetrahydro-5-pynmidinyljcarbonyl} glycine, N-[(6-Hydroxy-1,3-bis {[2-(methyloxy )phenyl]methyl} -2,4-dioxo-1,2,3,4-tetrahydro-5-pynmidinyl)carbonyl]glycme, N-({l,3-Bis[(2-chlorophenyl)methyl]-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl}carbonyl)glycine, N-[(l ,3-DihcxyI-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pynmidmyl)carbonyI]glycine, N-{[l-Cyclohexyl-6-hydroxy-3-(2-methylcyclohexyl)-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl}glycine, N-{[l-Cyclohexyl-6-hydroxy-3-(2-naphthalenyl)-2,4-dioxo-l,2,3,4-tetrahydro-5-pynmidinyl]carbonyl} glycine, N-[( 1 -Cyclohexyl-3-hexyl-6-hydroxy-2,4-dioxo1,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycme, N-[(l,3-Dicycloheptyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycine, N-[(l,3-Dicyclopentyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycine, N-{[l-Cyclohexyl-3-(2,3-dimethylcyclohexyl)-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidiny I]carbonyl} glycine, 4-[5-{[(Carboxymethyl)aminoJcarbonyl}-3-cyclohexyl-4-hydroxy-2,6-dioxo-3,6-dihydro-1 (2i/)-pynmidinyl]cyclohexanecarboxyhc acid, N- {[1 -Cyclohexyl-3-(4-ethylcyclohexyl)-6-hydroxy-2,4-dioxo~1,2,3,4-tetrahydro-5-pynmidinyljcarbonyl} glycine; cis-4-[3-Cyclohexyl-5-( {[2-(ethyloxy)-2 -oxoethyljammo } carbonyl)-4-hydroxy-2,6-dioxo-3,6-dihydro-l(2H)-pynmidinyl]cyclohexanecarboxyhc acid, N-{[l-Cyclohexyl-6-hydroxy-3-(l-methylcyclohexyl)-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidiny Ijcarbonyl} glycine; 3-[5- {[(Carboxymethyl)amino]carbonyl f -3-cyclohexyl-4-hydroxy-2,6-dioxo-3,6-dihydro-1 (2H)-pyrimidinyl]cyclohexanecarboxyhc acid, N- {[1 -Cyclohexyl-6-hydroxy-2,4-dioxo-3-(2-oxo-2-phenylethyl)-1,2,3,4-tetrahydro-5-pyrimidmyl]carbonyl}glycuie; N-[(l-Cyclohexyl-6-hydroxy-3-{2-[4-(methyloxy)pheny[]-2-oxoethyH-?,4-dioxo-1,2,3,4-tetrahydro-5-pynmidmyl)carbonyl]glycme, N-({l-Cyclohexyl-6-hydroxy-3-[2-(4-methylphenyl)-2-oxoethyt]-2,4-dioxo-1,2,3,4-tetrahydro-5 -pyrimidiny 1} carbony l)glycine, N-{[l-Cyclohexyl-3-(3,3-dmiethyl-2-oxobutyl)-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidmyl]carbonyl} glycine, N-({l-Cyclohexyl-3-[2-(4-fluorophenyl)-2-oxoethyl]-6-hydroxy-2,4-dioxo-l,2,3.4-tetrahydro-5 -pyrimidmyl} carbonyDglycme, N-( {3-[2-(4-Cyanophenyl)-2-oxoethyl]-1 -cyclohexyl-6-hydroxy-2 4 -dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl}carbonyl)glycine, N-({3-[2-(l-Benzofuran-2-yl)-2-oxoethyl]-l-cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidmyl}carbonyl)glycme, N-{[3-Cyclohexyl-6-hydroxy-l-(l-naphthalenyl)-2,4-dioxo-1,2,3,4-tetrahydro-5-pynmidinyl]carbonyl} glycine, N-{[3-Cyclohexyl-l-(4,4-dimethylcyclohexyl)-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidmyl]carbonyl} glycine; N-({l-Cyclohexyl-3-[(2,3-difluorophenyl)methyl]-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl}carbonyl)glycme. Ethyl N-[(l,3-dicyclohexyl-6-hydroxy-2,4-dioxo-1,2,3,4-tctrahydio-5-pyrimidinyl)carbonothioyl]glycmate, N-[(l,3-Dicyclohexyl-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)carbonothioyl]glycine, 6-[5-{[(Carboxymethyl)amino]carbonylj-3-cyclohexyl-6-hydroxy-2,4-dioxo-3,4-dihydro-l(2#)-pynmidinyl]hexanoic acid, 6-[5-{[(Carboxymethyl)ammo]carbonothioyl}-3-cyclohexyl-6-hydroxy-2,4-dioxo-3,4-dihydro-1 (2H)-pyrimidmyl]hexanoic acid, N-({l-Cyclohexyl-3-[(3,4-dichlorophenyl)methyl]-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl}carbonyl)glycine. N[(l~Cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidmyl)carbonyl]glycine, N-( {3-Cyclohexyl-6-hydroxy-1 -[trans-4-(methyloxy)cyclohexyl]-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl}carbonyl)glycine, N-({l-[l,r-Bi(cyclohexyl)-4-yl]-3-cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidmyl} carbonyl)glycine, N-{[6-Hydroxy-2,4-dioxo-l,3-bis(l-propylbutyl)-1,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine, N-({3-(2-Cyclopropylethyl)-6-hydroxy-l [3-(methyloxy)phenyl]-2,4-dioxo-l,2,3,4-tetrahydro-5 -pyrimidinyl} carbonyl)glycme, N-{[3-Cyclohexyl-6-hydroxy-2,4-dtoxo-l-(4-phenylcyclohexyl)-l,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine, N-({l-Cyclohexyl-3-[(3,4-difluorophenyl)methyl]-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pynmidinyl}carbonyl)glycme, N-({3-(2-Cyclopropylethyl)-6-hydroxy-l-[4-(methyloxy)phenyl]-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl}carbonyl)glycme, N-{[3-(2-Cyclopropylethyl)-6-hydroxy-l-(3-nitrophenyl)-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyljcarbonyl} glycine, N-({3-(2-Cyclopropylethyl)-6-hydroxy-2,4-dioxo-1 -[4-(2-thienyl)phenyl]-l ,2,3,4-tetrahydro-5-pyrimidmyl}carbonyl)glycine, N-{[l,3-Bis(l-ethylpropyl)-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidmyl]carbonyl} glycine. N-[(6-Hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pynmidmyl)carbonyl]glycine, N-[(l -Cyclohexyl-6-hydroxy-2,4-dioxo-3- {[4-(tnfluoromethyl)phenyl] methyl} -1,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycme, N-[(l,3-Dibutyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pynniidinyl)carbonyl]glycine, N- {[1,3-Bis(2-cyclopropylethyl)-6~hydroxy-2,4-dioxo-1,2,3.4-tetrahydru-5-pyrimidmyl]carbonyl} glycine, N-{[6-Hydroxy-l,3-bis(2-methylpropyl)-2,4-dioxo-l,2,3.4-tetrdhydro-5-pyrimidmyl]carbony 1} glycine; N-({3-(2-Cyclopropylethyl)-6-hydroxy-1 -[3-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2,4-dioxo-1,2,3,4-tettahydro-5-pyrimidinyl}carbonyl)glycine, N-( {3-(2-Cyclopropylethyl)-6-hydroxy-1 -[4-(2-methyl-1,3-thiazol-4-yl)phenyl]-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidmyl}carbonyl)glycine, N- {[3-Cyclohexyl-6-hydroxy-2,4-dioxo-1 -(4-pipendmyl)-1,2,3,4-tetrahy dro-5-pyrimidinyljcarbonyl} glycine; N-( {3-(2-Cyclopropylethyl)-1 -[4-(2-furanyl)phenyl]-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl} carbonyl)glycme, N- {[1,3-Bis(l, 1 -dimethylpropyl)-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidiny l]carbonyl} glycine, N-{[3-Cyclohexyl-6-hydroxy-2,4-dioxo- l-(3-piperidinyl)-l,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine, N-{[3-Cyclohexyl-6-hydroxy-2,4-dioxo l-(l~{[(phenylmethyl)oxy]carbonyl)-3-piperidinyl)-1,2,3,4-tetrahydro-5-pynmidmy ljcarbonyl} glycine, N-{[l-(l-Acetyl-3-pipendmyl)-3-cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pynmidmyl]carbonyl}glycme; N-[(l-Cyclohexyl-3-{[4-fluoro-2-(tiifluoromethyl)phenyl]methylJ-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycine, N-({3-[(2-Bromophenyl)methyl]-l-cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidmyl} carbonyl)glycine, N-({l-Cyclohexyl-3-[(2,6-dichlorophenyl)methyl]-o-hydroxy-2.4-dioxo-1,2,3,4-tetrahydro-5 -pyrimidinyl} carbonyl)glycme, N-[(3- {[2-Bromo-5-(methyloxy)phenyl]methyl} -1 -cyclohexyl-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pynmidiny l)carbonyl]glyc me, N-[(3- {[2,4-Bis(tnfluoromethyl)phenyl jmethyl} -1 -cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glyane, N-({3-[(2-Bromo-5-fluorophenyl)methyl]-l-cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5 -pyrimidinyl} carbonyl)glycuie, N-[(3-{[2-Bromo-4-(l,l-dimethylethyl;phenyl]methyl)-l-cyclohexyl-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidmyl)carbonyl]glycme, 7^-({l-Cyclohexyl-6-hydroxy-3-[(2-methylphenyl)methyl]-2,4-dioxo-l,2,3,4-tetrahydro-5-pynmidinyl}carbonyl)glycme, N-{[l-Cyclohexyl-3-(l,l-dimethylpropyl)-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro 5-pyrimidinyl]carbonyl} glycine; and N-{[l,3-Bis(2,6-dichlorophenyl)-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine Processes for preparing the compound of formula (I) are also withm the ambit of this invention To illustrate, a process for preparing a compound of formula (I) (Formula Removed) wherein X, Y, R1, R2, R3 and R4 are the same as defined above for formula (I), the process comprising treating a compound of formula A (Formula Removed) wherein R1 and R4 are the same as for those groups in formula (J) with glycine and an appropriate base, such as l,8-diazabicyclo[5 4 0]undec-7-ene, in an appropriate solvent, such as ethanol, under either conventional thermal conditions or by microwave irradiation, to form a compound of formula (I) where Y is O, R2 is -OH, and R3 is H, or a process for preparing a compound of formula (I) wherein X, Y, R1, R2, R3 and R4 are the same as defined above for formula (1), the process comprising treating a compound of formula B (Formula Removed) wherein X, Y, R1, R2, R3 and R4 are the same as for those groups in formula (I) with an alkah such as sodium hydroxide, in an appropriate solvent, such as aqueous ethanol, at a suitable temperature such as room temperature, to form a compound of formula (1) where R" is -OH, or a process for preparing a compound of formula (I) wherein X, Y, R1, R , R3 are the same as defined above for formula (I) and R4 is pipendmyl, the process comprising treating a compound of formula C (Formula Removed) wherein X, Y, R1, and R3 are the same as for those groups in formula (I) with an acylatmg agent such as acetic anhydride, in an appropriate solvent, such as acetic acid, at a suitable temperature such as 130 °C, to form a compound of formula (I) where R2 is -OH, and R is acylpipendinyl, It will be appreciated by those skilled in the art that the compounds of formula (I) may exist in one or more tautomeric forms such as (Formula Removed) All tautomenc forms of the compounds described herein, including mixtures thereof, are intended to be encompassed within the scope of the invention. Generally, the compounds exemplified herein have been assigned names based on the structure of the tautomer of formaula (IA) It should be understood that any reference to named compounds of this invention is mtended to encompass all tautomers of the named compounds and any mixtures of tautomers of the named compounds The compounds of formula (1) may be prepared m crystalline or non-crystalline form, and, if crystalline, may optionally be solvated, e g as the hydrate This invention includes within its scope stoichiometnc solvates (e.g. hydrates) as well as compounds containing variable amounts of solvent (e.g water) Certain of the compounds described herein may contain one or more chiral atoms, or may otherwise be capable of existing as two enantiomers The compounds claimed below include mixtures of enantiomers as well as purified enantiomers or enantiomerically ennched mixtures. Also included within the scope of the invention are the individual isomers of the compounds represented by formula (I), or claimed below, as well as any wholly or partially equilibrated mixtures thereof The present invention also covers the individual isomers of the claimed compounds as mixtures with isomers thereof in which one or more chiral centers are inverted Where there are different isomeric forms they may be separated or resolved one from the other by conventional methods, or any given isomer may be obtained b> conventional synthetic methods or by stereospecific or asymmetric syntheses While it is possible that, for use in therapy, a compound of formula (I j, as well as salts, solvates and the like, may be administered as a neat preparation, 1 e no additional earner, the more usual practice is to present the active ingredient confected with a carrier or diluent Accordingly, the invention further provides pharmaceutical compositions, which mcludes a compound of formula (I) and salts, solvates and the like, and one or more pharmaeeutically acceptable earners, diluents, or excipients The compounds of formula (I) and salts, solvates, etc, are as descnbed above The carriers), diluent(s) or excipient(s) must be acceptable in the sense of being compatible with the other ingredients of the formulation and not deletenous to the recipient thereof In accordance with another aspect of the invention there is also provided a process for the preparation of a pharmaceutical formulation including admixing a compound of the formula (1), or salts, solvates etc, with one or more pharmaeeutically acceptable earners, diluents or excipients It will be appreciated by those skilled m the art that certam protected denvatives of compounds of formula (I), which may be made pnor to a final deprotection stage, may not possess pharmacological activity as such, but may, in certain instances, be administered orally or parenterally and thereafter metabolised in the body to form compounds of the invention which are pharmacologically active. Such denvatives may therefore be descnbed as "prodrugs" Further, certain compounds of the invention may act as prodrugs of other compounds of the invention. All protected denvatives and prodrugs of compounds of the invention are included within the scope of the invention It will further be appreciated by those skilled m the art, that certain moieties, known to those skilled m the art as "pro-moieties" may be placed on appropnate functionalities when such functionalities are present within compounds of the invention Preferced prodrugs for compounds of the invention include, esters, carbonate esters, hemi-esters, phosphate esters, nitro esters, sulfate esters, sulfoxides, amides, carbamates, azo-compounds, phosphamides, glycosides, ethers, acetals and ketals Pharmaceutical compositions may be presented in unit dose fonns containing a predetermined amount of active ingredient per unit dose Such a unit may contain, for example, 0 5 mg to 1 g, preferably 1 mg to 700 mg, more preferably 5 mg to 100 mg of a compound of the formula (I), depending on the condition being treated, the route of administration and the age, weight and condition of the patient, or pharmaceutical compositions may be presented m unit dose forms containing a predetermined amount of active ingredient per unit dose Preferred unit dosage compositions are those containing a daily dose or sub-dose, as herein above recited, or an appropriate fraction thereof, of an active ingredient. Furthermore, such pharmaceutical compositions may be prepared by any of the methods well known in the pharmacy art. Pharmaceutical compositions may be adapted for administration by any appropriate route, for example by the oral (including buccal or sublingual), rectal, nasal, topical (including buccal, sublingual or transdermal), vaginal or parenteral (including subcutaneous, intramuscular, intravenous or intradermal) route. Such compositions may be prepared by any method known m the art of pharmacy, for example by bringing into association a compound of formal (1) with the carner(s) or excipient(s). Pharmaceutical compositions adapted for oral administration may be presented as discrete units such as capsules or tablets; powders or granules, solutions or suspensions in aqueous or nonaqueous liquids; edible foams or whips, or oil-m-water liquid emulsions or water-m-oil liquid emulsions Capsules are made by preparing a powder mixture, as descnbed above, and filling formed gelatin sheaths. Glidants and lubricants such as colloidal silica, talc, magnesium stearate, calcium stearate or solid polyethylene glycol can be added to the powder mixture before the filling operation A disintegrating or solubihzing agent such as agN-agar, calcium carbonate or sodium carbonate can also be added to improve the availability of the medicament when the capsule is ingested Moreover, when desired or necessary, suitable bmders, lubricants, disintegrating agents and coloring agents can also be incorporated mto the mixture Suitable binders include starch, gelatin, natural sugars such as glucose or beta-lactose, corn sweeteners, natural and synthetic gums such as acacia, tragacanth or sodium alginate carboxymethylcellulose, polyethylene glycol, waxes and the like. Lubricants used in these dosage forms include sodium oleate, sodium stearate. magnesium stearate, sodium benzoate, sodium acetate, sodium chloride and the like Disintegrators include, without limitation, starch, methyl cellulose, agar, bentonite, xanthan gum and the like Tablets are formulated, for example, by preparing a powder mixture, granulating or slugging, adding a lubricant and dismtegrant and pressing into tablets A powder mixture is prepared by mixing the compound, suitably comminuted, with a diluent or base as descnbed above, and optionally, with a binder such as carboxymethylcellulose, an ahginate, gelatin, or polyvinyl pyrrohdone, a solution retardant such as paraffin, a resorption accelerator such as a quaternary salt and/or an absorption agent such as bentonite, kaolin or dicalcium phosphate The powder mixture can be granulated by tablet forming dies by means of the addition of stearic acid, a stearate salt, talc or mineral oil The lubricated mixture is then compressed into tablets The compounds of the present invention can also be combined with a free flowing inert earner and compressed into tablets directly without going through the granulating or slugging steps A clear or opaque protective coating consisting of a sealing coat of shellac, a coating of sugar or polymeric material and a polish coating of wax can be provided Dyestuffs can be added to these coatings to distinguish different unit dosages Oral fluids such as solution, syrups and elixirs can be prepared in dosage unit form so that a given quantity contains a predetermined amount of a compound of formula (I) Syrups can be prepared by dissolving the compound m a suitably flavored aqueous solution, while elixirs are prepared through the use of a non-toxic alcoholic vehicle Suspensions can be formulated by dispersing the compound in a non-toxic vehicle Solubihzers and emulsifiers such as ethoxylated isostearyl alcohols and polyoxy ethylene sorbitol ethers, preservatives, flavor additive such as peppermint oil or natural sweeteners or saccharin or other artificial sweeteners, and the like can also be added Where appropriate, dosage unit pharmaceutical compositions for oral administration can be microencapsulated. The formulation can also be prepared to prolong or sustain the release as for example by coating or embedding particulate material m polymers, wax or the like Pharmaceutical compositions adapted for rectal administration may be presented as suppositories or as enemas Pharmaceutical compositions adapted for vaginal administration may be presented as pessaries, tampons, creams, gels, pastes, foams or spray formulations Pharmaceutical formulations adapted for parenteral administration include aqueous and non-aqueous sterile injection solutions which may contain anti-oxidants, buffers, bactenostats and solutes which render the composition isotonic with the blood of the intended recipient, and aqueous and non-aqueous sterile suspensions which may include suspending agents and thickening agents The pharmaceutical compositions may be presented in unit-dose or multi-dose containers, for example sealed ampoules and vials, and may be stored in a freeze-dned (lyophihzed) condition requiring only the addition of the sterile liquid earner, for example water for injections, immediately prior to use. Extemporaneous injection solutions and suspensions may be prepared from sterile powders, granules and tablets It should be understood that in addition to the ingredients particularly mentioned above, the pharmaceutical compositions may include other agents conventional in the art having regard to the type of formulation in question, for example those suitable for oral administration may include flavouring agents. A therapeutically effective amount of a compound of the present invention will depend upon a number of factors including, for example, the age and weight of the intended recipient, the precise condition requiring treatment and its severity, the nature of the formulation, and the route of administration, and will ultimately be at the discretion of the attendant prescribing the medication However, an effective amount of a compound of formula (I) for the treatment of anemia will generally be in the range of 0 001 to 100 mg/kg body weight of recipient per day, suitably m the range of 01 to 10 mg/kg body weight per day For a 70kg adult mammal, the actual amount per day would suitably be from 7 to 700 mg and this amount may be given in a single dose per day or in a number (such as two, three, four, five or six) of sub-doses per day such that the total daily dose is the same. An effective amount of a salt or sohate, etc may be determined as a proportion of the effective amount of the compound of formula (I) per se It is envisaged that similar dosages would be appropriate for treatment of the other conditions referred to above Definitions CDI - carbonyl di-imidazole DBU -l,8-diazabicyclo[5 4 Ojundee-7-ene D1AD - diisopropyl azodicarboxyiate DMA - NN-dimethylacetamide DMF - iV.N-dimethylformamide DMSO - dimethylsulfoxide HPLC - high pressure liquid chromatography LC/MS - liquid ehromatography/mass spectrometry NMR - nuclear magnetic resonance rt - room temperature TFA - Tnfluoroacetic acid THF - tetrahydro&ran Chemical Background: The compounds of this invention may be made by a vanety of methods, including standard chemistry. Any previously defined variable will continue to have the previously defined meaning unless otherwise indicated. Illustrative general synthetic methods arc set out below and then specific compounds of the invention as prepared are given in the examples Compounds of general formula (I) may be prepared by methods known in the art of organic synthesis as set forth m part by the following synthesis schemes In all of the schemes described below, it is well understood that protecting groups for sensitive or reactive groups are employed where necessary in accordance with general principles of chemistry. Protecting groups are manipulated according to standard methods of organic synthesis (T W Green and P G M Wuts (1991) Protecting Qroups in Organic Synthesis. John Wiley & Sons) These groups are removed at a convenient stage of the compound synthesis using methods that are readily apparent to those skilled m the art. The selection of processes as well as the reaction conditions and order of their execution shall be consistent with the preparation of compounds of formula (I). Those skilled in the art will recognize if a stereocenter exists in compounds of formula (I) Accordingly, the present invention includes both possible stereoisomers and includes not only racemic compounds but the individual enantiomers as well When a compound is desired as a single enantiomer, it may be obtained by stereospecific synthesis or by resolution of the final product or any convenient intermediate Resolution of the final product, an intermediate, or a starting material may be effected by any suitable method known in the art See, for example, Stereochemistry of Organic Compounds by E L. Eliel, S. H Wilen, and L N Mander (Wiley-Interscience, 1994). Illustrated Methods of preparation a) 1 NaH, THF, rt 2. R'NCO, 60 °C, b) 1 NaH, THF or dioxane, rt 2 R*NCX, heat, c) H2NCH2CO2H, DBU, EtOH, 160 °C, microwave (Scheme Removed)…………..2 a) R1NH2, CH2C12 or R'NH, HC1, base, CH2C12, b) CH2(C(O)C1)2, CH2C1... reflux or CH2(CO2Et)2, NaOEt, MeO(CH2)2OH, reflux or 1 Et02CCH2COCl, CHC13, 70 °C 2 DBU, CHC13, 70 °C; c) 1 YCNCH2CO2Et„ EtPr'2N, CHCU or CH,C12 2 aq NaOH, EtOH, rt (Scheme Removed)…………..3 a) OCNCH2CO2Et, EtPr2N, CHC13 or CH2C12, b) 1 R1Hal, Na/K2CO3, DMF or DMA, 100 °C or R'Hal, pol-BEMP, DMF, 120 °C, microwave 2 aq NaOH, MeOH or EtOH, rt (Scheme Removed)…………..5 a) 1. CH2(CO2H)2, THF, 0 °C - rt 2 EtOH, reflux, b) 1 OCNCH2CO2Et, EtPrSN, CH2C12 2. aq NaOH, EtOH, n (Scheme Removed)…………..6 a) 1 Phthalimide, DIAD, PPh,, THF 2 (NH2)2, EtOH, reflux (Scheme Removed)…………..7 a) AC20,AcOH, 130 °C Experimentals Example 1 (Formula Removed) N-{[1-(4-Chlorophenyl)-6-hydroxy-2,4-dioxo-3-(phenylmethyl)-l,2,3,4-tetrahydro-5- pynmidinyllcarbonyl 1 glycine la). Diethyl {lYphenylmethyl)aminolcarbonyl} propanedioate A solution of diethyl malonate (1 52 mL, 10 0 mmoles) in dry tetrahydrofuran (20 mL) was added to a suspension of sodium hydride (60% suspension m mineral oil, 500 mg, 12 5 mmoles) under argon atmosphere at room temperature After stirring for 15 minutes, a solution of benzyl isocyanate (1 33 mL, 10 0 mmoles) was added and the mixture was heated at 60°C for 3 hours The mixture was cooled, carefully acidified with 1 molar hydrochloric acid and the tetrahydrofuran evaporated. The mixture was diluted with water and extracted twice with chloroform I he combined extracts were washed twice with bnne, dried and evaporated Crystallization from ether-hexane afforded the title compound as a white solid, 1.2 g, 40%. 1H NMR (400 MHz, DMSO-d6) δ ppm 1 20 (t, J=7 20 Hz, 6 H) 4 11 -4.20 (m, 4 H) 4.33 (d, J=6.06 Hz, 2 H) 4 56 (s, 1 H) 7 24 (s. 1 H) 7 25 - 7 36 (m, 5 H) δ 74 (t, .J=5.68 Hz, 1 H). 1b) Ethyl 1 -(4-chlorophenyl)-6-hydroxy-2,4-dioxo-3-(phenylmethyl)-1,2.3.4-tetrahydro-5-pyrimiduiecarboxylate. Diethyl {[(phenylmethyl)amino]carbonyl}propanedioate (293 mg, 1 0 mmoles) was added to a suspension of sodium hydnde (60% suspension in mineral oil, 100 mg, 2 5 mmoles) in dry tetrahydrofuran (50 mL) and stirred for 10 minutes under argon 4-Chlorophenyl isocyanate was added and the mixture was heated under reflux for 2 hours, cooled, acidified with 1 molar hydrochloric acid and extracted with ethyl acetate Flash chromatography (hexane-ethyl acetate) afforded the title compound (225 mg, 56%) 1H NMR (400 MHz, DMSO- 1c) N-{[1-(4-Chlorophenyn-6-hydroxy-2,4-dioxo-3-(phenylmethyl)-1.2.3.4-tetrahydro-5-pyrimidinyllcarbonyl}glycine. A mixture of ethyl l-(4-chlorophenyl)-6-hydroxy-2,4-dioxo-3-(phenylmethyl)-l,2,3,4-tetrahydro-5-pynmidmecarboxylate (225 mg, 0 56 mmoles), DBU (200 mg, 1 31 mmoles) and glycine (100 mg, 1 33 mmoles) m ethanol (10 mL) was sealed in a flask and heated in a microwave reactor at 160°C for 1 hour The reaction mixture was evaporated, dissolved m chloroform and washed with 1 molar hydrochloric acid. Evaporation of the residue and separation by preparative HPLC (10-80% acetonitrile-water-0.1%TFA) afforded the title compound (25 mg, 10%) 1H NMR (400 MHz, DMSO-d6) δ ppm 4 13 (d. J=5 81 Hz, 2 H) 5 03 (s, 2 H) 7 24 - 7 29 (m, 1 H) 7.31 - 7.38 (m, 4 H) 7 42 (d, J=8 34 Hz, 2 H) 7 52 - 7 58 (m, 2 H) 10 07 (s, 1 H) 13 11 (s, 1H) Example 2 (Formula Removed) N- {[1-{[2.4-Bis(methyloxy)phenyllmethyl}-6-hydroxy-2,4-dioxo-3-(phenylmethyl)-1,2,3.4-tetrahydro-5-pynmidmvl]carbonyl} glycine 2a) Ethyl l-{[2,4-bis(methyloxy)phenynmethyl}-6-hydroxy-2.4-dioxo-3-(phenylmethyl)-1.2.3.4-tetrahydro-5-pyrimidinecarboxylate Diethyl {[(phenylmethyl)amino]carbonyl}propanedioate (820 mg, 2 8 mmoles) was added to a suspension of sodium hydride (60% suspension in mmeral oil, 280 mg, 7 0 mmoles) in dry tetrahydrofuran (50 mL) and stirred for 10 minutes under argon 2,4-dimethoxybenzyl isocyanate (1 0 mL, 6 0 mmoles) was added and the mixture heated under reflux for 3 hours, cooled, acidified with I molar hydrochloric acid and extracted with ethyl acetate Flash chromatography (30% methanol in dichloromethane) afforded the title compound (480 mg, 39%) 1H NMR (400 MHz, DMSO-d6) δ ppm 1 15 (t, J=6 69 Hz, 3 H) 3 71 (s, 3 H) 3 78 (s, 3 H) 4 09 (q, J=5 05 Hz, 1 Hj 4.81 (s, 2 H) 4 92 (s, 2 H) 6.40 - 6 59 (m, 3 H) 6 62 - 7 26 (m, 5 H) 2b) N- {[1- {r2.4-bis(methyloxy)phenyl~lmethyl I -6-hydroxy-2.4-dioxo-3-(phenylmethyl)-1.2.3.4-tetrahydro-5-pyrimidinyllcarbonyl} glycine A mixture of ethyl 1 - {[2,4- bis(methyloxy)phenyl]methyl} -6-hydroxy-2,4-dioxo-3-(phenylmethyl)-1,2,3,4-tetrahydro-5-pyrimidmecarboxylate (110 mg, 0 25 mmoles), DBU (76 mg, 0.5 mmoles) and glycine (38 mg, 0 5 mmoles) m ethanol (5 mL) was sealed in a flask and heated in a microwave reactor at 160°C for 1 hour. The reaction mixture was diluted with 1 molar hydrochloric acid and extracted with ethyl acetate Purification by preparative HPLC (10-80% acetomtnle-water-0 1%TFA) afforded the title compound (50 mg, 42%) 1H NMR (400 MHz, DMSO-d6) δ ppm 3.71 - 3 81 (m, 6 H) 4 13 (d, .J=5.31 Hz, 2 H) 4.92 (s, 2 H) 5.03 (s, 2 H) 6 39 - 6 49 (m, 1 H) 6 56 (s, 1 H) 6 81 (d, J=8 08 Hz, 1 H) 7.24 - 7.36 (m, 5 H) 10 10 (s, 1 Hj 13 10 (s, 1 H) Example 3 (Formula Removed) AL,(ri-f4-Chlorophenyl>-6-hydroxy-4-oxo-3-(phenylmemvl)-2-thioxo-1.2.3.4-tetrahydro-5- Pvrrmidinyl]carbonyli glycine 3a) Ethyl 1 -(4-chlorophenyl)-6-hydroxy-4-oxo-3-(phenylmethyl)-2-thioxo-1.2.3.4-tetrahydro-5-pynmidinecarboxylate Diethyl {[(phenylmethyl)ammo]carbonyljpropanedioate (400 mg, 1 36 mmoles) was added to a suspension of sodium hydnde (60% suspension in mineral oil, 200 mg, 5 0 mmoles) in dry dioxan (15 mL) and stirred for 10 minutes under argon 4-Chlorophenyl isothiocyanate (340 mg, 2 0 mmoles) was added and the mixture sealed in a pressure flask heated in a microwave reactor at 100°C for 1 hour The mixture was taken up in dichloromethane, washed with 1 molar hydrochloric acid and dried Flash chromatography (hexane-ethyl acetate) afforded the title compound (85 mg, 20%) 1H NMR (400 MHz, DMSO- 3b) N-{ri-(4-Chlorophenyl)-6-hydroxy-4-oxo-3-(phenylmethyl)-2-thioxo-1.2.3.4-tetrahydro-5-pyrimidinyHcarbonyl \ glycine A mixture of ethyl l-(4-chlorophenyl)-6-hydroxy-4-oxo-3-(phenylmethyl)-2-thioxo-l,2,3,4-tetrahydro-5-pynmidinecarboxylate (85 mg, 0 21 mmoles), DBU (90 mg, 0 6 mmoles) and glycine (60 mg, 0 8 mmoles) m ethanol (5 mL) was sealed in a flask and heated in a microwave reactor at 160°C foi 1 hour The reaction mixture was diluted with 1 molar hydrochloric acid and extracted twice with ethyl acetate The combined extracts were washed with 1 molar hydrochloric acid, dried and evaporated Purification by preparative HPLC (10-80% acetonitnle-water-0.1%TFA) afforded the title compound (23 mg, 24%) 1H NMR (400 MHz, DMSO-d6) δ ppm 4 14 (d, J=5 81 Hz, 2 H) 5 67 (s, 2 H) 7 24 (t, J=6 95 Hz, 1 H) 7 29 - 7 40 (m, 7 H) 7.54 (d, J=8 59 Hz, 2 H) 10.10 (s, 1 H) 13 11 (s, 1 H) Example 4 (Formula Removed) N-({6-Hydroxy-2,4-dioxo-3-(phenylmethyl)-1 -[3-CtrifluoromethypphenvH-1,2.3,4-tetrahydro-5- pynmidinyll carbonyl)glycine 4a) Ethyl 6-hydroxy-2.4-dioxo-3-(phenylmethyl)-l-[3-(trifluoromethyl')phenvtl-1,2.3.4-tetrahydro-5-pyrimidinecarboxylate. Diethyl {[(phenylmethyl)ammo]carbonyl}propanedioate (200 mg, 0 68 mmoles) was added to a suspension of sodium hydride (60% suspension in mineral oil, 100 mg, 2 5 mmoles) in dry dioxane (5 mL) and stirred for 10 minutes under argon. 3-Tnfluorophenyl isocyanate (140 uL, 1 02 mmoles) was added and the mixture sealed in a pressure flask heated in a microwave reactor at 100°C for 40 minutes The mixture was taken up in dichloromethane, washed with 1 molar hydrochloric acid and dried. The mixture was evaporated and azeotroped with ethanol The residue was slurried in diethyl ether to give the title compound (110 mg, 37%) 1H NMR (400 MHz, DMSO-d6) δ ppm 1 10 (t, JM> 95 Hz, 3 H) 3.39 (q, J=6 99 Hz, 2 H) 4 89 - 4.94 (m, 2 H) 7 18 - 7 23 (m, 2 H) 7 24 - 7 31 (m, 3 H) 7 44 - 7 55 (m, 2 H) 7 59 -7 69 (m, 2 H) 4b) N-({6-hydroxy-2,4-dioxo-3-(phenylmethyl)-l-[3-(tnfluoromethyl)phenyl]-1,2,3,4-tetrahydro-5-pyrimidinyl}carbonyl)glycine A mixture of ethyl 6-hydroxy-2,4-dioxo-3-(phenylmethyl)-1 -[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydro-5-pynmidinecarboxylate (110 mg, 0 25 mmoles), DBU (100 mg, 0 6 mmoles ) and glycine (40 mg, 0.5 mmoles) in ethanol (5 mL) was sealed in a flask and heated in a microwave reactor at 160°C for 1 hour The reaction mixture was diluted with 1 molar hydrochloric acid and extracted twice with dichloromethane. Purification by preparative HPLC (10-80% acetonitnle-water-0 1%TFA) afforded the title compound (15 mg, 13%) 1H NMR (400 MHz, DMSO-d6) δ ppm 3 79 (d. J=5 05 Hz. 2 H) 4 97 (s, 2 H) 7 19 - 7 30 (m, 5 H) 7 46 - 7.57 (m, 2 H) 7 60 - 7 71 (m, 2 H) δ 27 (s, 1 H) 9 60 (s. 1 H) Example 5 (Formula Removed) N-lf6-Hvdroxy-2.4-dioxo-3-(phenylmethyl)-1.2.3.4-tetrahydro-5-pynmidmvllcarbonvU glycine 5a) Ethyl 6-hydroxy-2.4-dioxo-3-(phenylmethyl)-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate. Ethyl l-{[2,4-bis(methyloxy)phenyl]methyH-6-hydroxy-2,4-dioxo-3-(phenylmethyl)-l,2,3,4-tetrahydro-5-pynmidinecarboxylate (260 mg, 0 59mmoles) was stirred in a mixture of sulfunc acid (5.0 mL) and water (10 mL) for 3 hours The mixture was poured onto ice and the solid collected The aqueous was adjusted to pH3 and extracted three times with ethyl acetate The extracts were dried, evaporated and combined with the collected solid Purification by preparative HPLC (acetonitnle-water-0.1% TFA) gave the title compound (106 mg, 62%) 1H NMR (400 MHz, CHLOROFORM-d6) δ ppm 1 28 (t, J=7 07 Hz, 3 H) 4 14 (q, .J=7 16 Hz. 2 H) 5.09 (s, 1 H) 5 14 (s, 1 H)725-737(m,3H)742-752(m, 2 H) 1022 (s, 1 H) 1553 (s. 1 H) 5b) N- i r6-Hvdroxy-214-dioxo-3-( phenylmethyl)-1,2,3,4-tetrahydro-5- pynmidinvUcarbonyll glycine A mixture of ethyl 6-hydroxy-2,4-dioxo-3-(phenylmethyl)-l,2,3,4-tetrahydro-5-pyrimidmecarboxylate (100 mg, 0 34 mmoles). DBU (106 mg, 0 7 mmoles) and glycine (52 mg, 0.7 mmoles) in ethanol (5 mL) was sealed in a flask and heated in a microwave reactor at 160°C for 1 hour The reaction mixture was taken up in ethyl acetate and washed with 1 molar hydrochloric acid. Punfication by preparative HPLC (10-80% acetonitnle-water-0.1%TFA) afforded the title compound (15 mg, 14%) 1H NMR (400 MHz, DMSO-d6) δppm 4.11 (s, 2 H) 4 95 (s, 2 H) 7 23 - 7 35 (m, 5 H) 9 84 (s, 1 H) 12 09 (s, 1 H) Example 6 (Formula Removed) N-{r6-Hvdroxy-2.4-dioxo-l-phenyl-3-(phenylm ethyl )-l. 2.3.4-tetrahydro-5-pyrimidinyncarbonyl \ glycine 6a) Ethyl 6-hydroxy-2.4-dioxo-l-phenyl-3-(phenylmethyl)-1.2.3.4-tetrahydro-5-pyrimidinecarboxylate. Diethyl {[(phenylmethyl)arnino]carbonyl}propanedioate (420 mg, 1 43 mmoles) was added to a suspension of sodium hydride (60% suspension in mineral oil, 220 mg, 5 5 mmoles) m dry dioxan (10 mL) and stirred for 10 minutes under argon. Phenyl isocyanate (240 uL, 2.21 mmoles) was added and the mixture sealed m a pressure flask heated in a microwave reactor at 110°C for 1 hour The mixture was taken up in dichloromethane, washed with 1 molar hydrochlonc acid and evaporated onto silica gel Flash chromatography (ethyl acetate) gave the title compound (300 mg, 57%) 1H NMR (400 MHz, DMSO-d6) δ ppm 1 15 (t, J=7 07 Hz, 3 H) 3.99 - 4 07 (q, J=7 07 Hz, 2 H) 4 94 (s, 1 H) 7 08 - 7 13 (m, 2 H) 7 21 (ddd, J=8 46, 4.42, 4 29 Hz, 1 H) 7 26 - 7.33 (m, 5 H) 7 37 (t, J=7 45 Hz, 2 H) 6b) N- {[6-Hydroxy-2,4-dioxo-1 -phenyl-3-(phenylmethyl)-1,2,3,4-tetrahydro-5-pyrimidinyljcarbonyl} glycine. A mixture of ethyl 6-hydroxy-2,4-dioxo-1 -phenyl-3-(phenylmethyl)-l,2,3,4-tetrahydro-5-pyrrmidinecarboxylate (300 mg, 0 82 mmoles), DBU (150 mg, 1 0 mmoles) and glycine (120 mg, 1 6 mmoles) in ethanol (15 mL) was sealed m a flask and heated in a microwave reactor at 160°C for 1 hour The reaction mixture was filtered and the filtrate diluted with dichloromethane and washed with 1 molar hydrochloric acid. The aqueous was extracted with dichloromethane and the combined extracts dried and evaporated to give the title compound (50 mg, 15%) 1H NMR (400 MHz, DMSO-d6) δ ppm 3 81 (s, 2 H) 4 99 (s, 2 H) 7 14 (d, J=7 33 Hz, 2 H) 7 19 - 7 23 (m, 1 H) 7 25 - 7 34 (m, 5 H) 7 39 it, 1=1 45 Hz, 2 H) 9 84 (s, 1H) Example 7 (Formula Removed) N-r(l-(l.l-Dimethylethyl)-3-Jr4-fl.l-drmethylethyl)phenyl1methyl|-6-hydroxY-2.4-dioxo-1.2.3.4- tetrahydro-5-pynmidinyl)carbonyllglvcine 7a) 1 -(1. l-Dimethylethyl)-3- U4-( 1.1 -dimethylethyl)phenynmethyl} -2AM\H3H.5H)-pyrimidinetnone. A mixture oft-butyl isocyanate (571 uL, 5.0 mmoles) and 4-t-butylbenzylamine (880 uL, 5.0 mmoles) in dry dichloromethane was stirred for 1 hour Dichloromalonate (486 uL, 5.0 mmoles) was added and the mixture was heated under reflux for 1 hour The mixture was washed with IN hydrochlonc acid and evaporated onto silica gel Flash chromatography (10-35% ethyl acetate-hexane) gave the title compound (1 3 g, 79%) 1H NMR (400 MHz. CHLOROFORM-d6) δppm 1.32 (s, 9 H) 1 63 (s, 9 H) 3 60 (s, 2 H) 4 99 (s, 2 H) 7.37 (d, J=2 78 Hz, 4 H). 7b) Ethyl N-[(l-( 1, l-dimethylethyl)-3- ([4-( 1.1 -dimemvlemyl)phenyl1methyU-6-hydroxy-2.4-dioxo-1,2,3,4-tetrahydro-5-pynmidinyl)carbonynglycmate. l-(l,l-Dimethylethyl)-3-{[4-(l,l-dimethylethyl)phenyl]methyl}-2,4,6(lH,3H,5H)-pynmidinetnone (1 3 g, 3 93 mmoles) and diisopropylethylamine (1 36 mL, 7 86 mmoles) were stirred together in dry chloroform (25 mL) and treated with ethyl isocyanatoacetate (335 uL, 3 93 mmoles) The mixture was stirred for 3 hours, washed twice with 1 molar hydrochloric acid, dried and evaporated to give the title compound (1.8 g, quant.) IH NMR (400 MHz, CHLOROFORM-d)δ ppm 1 32 (t, J= 7 07 Hz, 3 H) 1 71 (s, 9 H) 1.73 (s, 9 H) 4 28 - 4 34 (m, 2 H) 5 03 - 5 07 (m, 2 H) 7 33 - 7 39 (m, 4 H) 10 21-10 30(m, IH). 7c) N-[( 1 -(1., 1 -Dimethylethyl)-3 - {[4-( 1,1 -dimethylethyl)phenyllmethyl} -6-hydroxy-2,4-dioxo-1.2.3.4-tetrahydro-5-pyrimidinyl)carbonyl] glycine. A mixture of ethyl N-[( 1 -(1,1 -dimethylethyl)-3- {[4-( 1, l-dimethylethyl)phenyl]methyH -6-hydroxy-2,4-dioxo-1,2,3,4-terrahydro-5 -pyrimidinyl)carbonyl]glycinate (1.8 g, 3 9 mmoles) and 1 molar sodium hydroxide solution (6 0 mL) m ethanol (5.0 mL) was stirred overnight The reaction was incomplete, therefore 6 molar sodium hydroxide was added. After 2 hours, the mixture was partitioned between ethyl acetate and 1 molar hydrochloric acid, the organic solution washed with 1 molar hydrochloric acid, dned and evaporated The title compound was obtained by crystallization from cold hexane (700 mg, 41%) IH NMR (400 MHz, DMSO-d6) δ ppm 1 25 (s, 9 H) 1 65 (s, 9 H) 4 11 (d, J=5 81 Hz, 2 H) 4 93 (s, 2 H) 7 20 (d, J=8.59 Hz, 2 H) 7 34 (d, J=8 34 Hz, 2 H) 10 06 (t, .J=5 56 Hz, 1 H) 13.06 (s, 1 H) Example (Formula Removed) N-(r6-Hvdroxy-2.4-dioxo-3-(phenylmethyl)-l-(2-pyndmyl)-1.2.3.4-tetrahydro-5- pynmidmvncarbonyl? glycine 8a) 2-Isocvaaatopyridine 2-Picohnic acid (1 0 g, 8 0 mmoles) was stirred in toluene (25mL) and treated with diphenylphosphoryl azide (2.0 mL, 9 3 mmoles) at room temperature under argon. Tnethylamme (1.34 mL, 9.6 mmoles) was added dropwise, stirred for 30 minutes then heated to 80°C for 2 hours. The mixture was cooled, the solid collected, washed with a little ethyl acetate, hexane and vacuum dried to give the title compound (750 mg, 78%) 1H NMR (400 MHz, DMSO-d6) δ ppm 8.62 (dd, J=4 93, 1 14 Hz, 1 H), 8 44 (d, J=6.32 Hz, 1 H), 8 04 (td, J=7 71, 2 02 Hz, 1 H), 7 91 (ddd, J=8.84, 6 95, 1 64 Hz, 1 H), 7 55 (s, 1 H), 7 51 - 7 55 (m, 1 H), 7.17 (d, y=8.84 Hz, 1 H), 7 00 (td, J=6 95, 1.26 Hz, 1 H) 8b) Ethyl 6-hydroxy-2.4-dioxo-3-(phenylmethyl)-l-(2-pyridinyl)-1.2.3.4-tetrahydro-5-pynmidmecarboxylate 2-Isocyanatopyridme (265 mg, 2 2 mmoles) was added to a suspension of sodium hydride (200 mg, 5 mmoles) and diethyl j[(phenylmethyl)ammo]carbonyl}propanedioate (example la, 425 mg, 1.45 mmoles) in anhydrous dioxane (10 mL) The mixture was heated in a microwave reactor at 110°C for 1 hour, cooled, dissolved in dichloromethane, washed with 1 molar hydrochloric acid and purified by flash chromatography (ethyl acetate - 10% methanol in ethyl acetate) to give the title compound (90 mg, 12%) IH NMR (400 MHz, DMSO-d6) δppm 8 93 (dd, J=7.20, 1.39 Hz, 1 H), 8.11 - 8 26 (m, 1 H), 7 19 - 7 45 (m, 7 H), 4 78 - 5 01 (m,2H),4 15 (q, J=l 24 Hz, 2 H), 1.24 (t, J=7.07 Hz, 3 H) 8c) N-{[6-hydroxy-2,4-dioxo-3-(phenylmethyl)-l-(2-pyridmyl)-l,2,3.4-tetrahydro-5-pyrimidinyncarbonyl}glycine A mixture of N- \ [6-hydroxy-2,4 dioxo-3-(phenylmethyl)-1-(2-pyridinyl)-l,2,3,4-tetrahydro-5-pynmidmyl]carbonyl}glycine (90 mg, 0 24 mmoles), glycine (90 mg, 1 2 mg) and DBU (150 mg, 1 0 mmoles) m ethanol (5 mL) was heated at 170°C for 1 hour m a microwave reactor Purification by preparative HPLC (acetonirnle - 0 1% TFA in water. 20-100%) gave the title compound (17 mg, 18%) 1H NMR (400 MHz, DMSO-d6) δ ppm 13 13 (s, 1 H), 10 07 (s, 1 H), 8 58 (dd, .J=4 93, 1 14 Hz, 1 H), 8 01 (td, J=7 71, 1 77 Hz, 1 H), 7.49 - 7 58 (m, 2 H), 7 26 - 7.36 (m, 6 H), 5 02 (s, 2 H), 4 15 (d, J=5 81 Hz, 2 H) Exmaple 9 (Formula Removed) mmoles) was added to a suspension of sodium hydride (60% suspension in mmeral oil, 220 mg, 5 5 mmoles) in dry dioxan (10 mL) and stirred for 10 minutes under argon 2-Nitrophenyl isocyanate (360 mg, 2.20 mmoles) was added and the mixture sealed in a pressure flask heated in a microwave reactor at 110°C for 1 hour The mixture was taken up in dichloromethane, washed with 1 molar hydrochloric acid and evaporated onto silica gel Flash chromatography (hexane to 0.5% formic acid in ethyl acetate) gave the title compound (59 mg, 7%) 1H NMR (400 MHz, DMSO-d6) δ ppm 8.16 (s, 1 H), 7.81 (s, 1 H), 7 68 (s, 1 H), 7 47 (s. 1 H), 7 08 - 7 38 (m, 5 H), 4 77 5.16 (m, 2 H), 4 12 (q, J=5 31 Hz, 2 H), 0 97 - 1 31 (m, 3 H) 9b) N-(r6-Hvdroxy-2.4-dioxo-l-phenyl-3-(phenylmethyU-1.2.3.4-tetrahydro-5-pyrimidinyllcarbQnyl)elvcine. A mixture of ethyl 6-hydroxy-l-(2-mtrophenyl)-2,4-dioxo-3-(phenylmethyl)-l,2,3,4-tetrahydro-5-pynmidmecarboxylate (59 mg. 0 14 mmoles), DBU (80 mg, 0 52 mmoles) and glycine (40 mg, 0 53 mmoles) in ethanol (3 mL) was sealed in a flask and heated in a microwave reactor at 170°C for 1 hour The reaction mixture was poured into 1 molar hydrochlonc acid and extracted with dichloromethane (x2) and washed with 1 molar hydrochloric acid. The title compound was obtained by purification by preparative HPLC (10-80% acetomtnle-water-0 1%TFA)(17 mg, 28%) 1H NMR (400 MHz, DMSO-d6) δ ppm 13 14 (br s , 1 H), 10 04 (br s , 1 H), 8.25 (dd, J=8 21, 1 14 Hz, 1 11), 7 93 (dt, .7-7 71, 1 26 Hz, 1 H), 7 71 - 7.81 (m, 2 H), 5 06 (s, 2 H), 4 14 (d, J=5 56 Hz, 2 H) Example 10 (Formula Removed) N-(|'l-Cyclohexyl-6-hydroxy-2.4-dioxo-3-(phenylmethyl)-1.2.3.4-tetrahydro-5- pynmidmvncarbonyl} glycine A microwave tube containing sodium hydride (60% suspension in oil, 46 mg, 1 15 mmoles) m dioxan (3 mL) was treated with diethyl {[(phenylmethyl)amino]carbonyl}~ propanedioate (example la, 100 mg, 0 34 mmoles) and stirred under argon until evolution ceased. Cyclohexyl isocyanate (90 uL, 0.7 mmoles) was added and the mixture was heated at 100°C for 30 minutes in a microwave reactor Glycine (48 mg, 0 65 mmoles) and DBU (4 drops) was added, the flask re-sealed and heated at 160°C for 1 hour in a microwave reactor The mixture was poured into 1 molar hydrochlonc acid and extracted with dichloromethane (x3) The combined extracts were washed with 1 molar hydrochlonc acid and brine, dried and evaporated to give the crude product Punfication by preparative HPLC (acetomtnle - water - 0 1% TFA, 20-100%) gave the title compound (10 mg, 7%) IH NMR (400 MHz, DMSO-d6) δ ppm 10 12 (t, J=5.18 Hz, 1 H), 7 23 - 7 34 (m, 6 H), 4.99 (s, 2 H), 4 65 (t, J=1 1 62 Hz, 1 H), 4 10 (d, J=5 81 Hz, 2 H), 2 21 -2 32 (m, 2 H), 1.78 (d, J=12 63 Hz, 2 H), 1 62 (s, 3 H), 1 22 - 1 33 (m. 3 H), 1 06 - 1 17 (m, 1 H) Example 11 (Formula Removed) N-{n-[(3-Cyanophenyl)methyl1-6-hydroxy-2,4-dioxo-3-(phenylmethyl)-1.2.3.4-tetrahydro-5- pynmidinyl]iarbonyl} glycine 1 la) Ethyl N-{f6-hydroxy-2.4-dioxo-3-(phenylmethyl)-1.2.3.4-tetrahydro-5-pyrimidinyllcarbonyll glvcinate. Ethyl isocyanatoacetate (2.24 mL, 20 mmoles) was added dropwise to a solution of l-(phenylmethyl)-2,4,6(lH,3H,5H)-pynmidmetnone (4 4 g, 20 mmoles) and ethyl dnsopropylamme (6 9 mL, 40 mmoles) in dichloromethane (120 mL) and stirred overnight under argon The mixture was washed with 1 molar hydrochloric acid, water and bnne, dned and evaporated The solid was slurned in diethyl ether, collected, washed with diethyl ether and hexane, dried to give the title compound (5 1 g, 73 %) IH NMR (400 MHz. DMSO- He) N-iri-r(3-Cyanophenyl>methyll-6-hydroxy-2.4-dioxo-3-(phenylmethyl)-1.2.3.4-tetrahydro-5-pyrimidipyllcarbonylIelvcine Ethyl N- {[1 -[(3-cyanophenyl)methyl]-6-hydroxy-2,4-dioxo-3-(phenylmethyl)-l,2,3,4-tetrahydro-5-pynmidmyl]carbonyliglycinate (280 mg, 0 6 mmoles) was dissolved in methanol (5 mL) and treated with 1 molar sodium hydroxide solution (4 mL) and stirred for 3 hours The mixture was acidified and extracted into ethyl acetate. Purification by preparative HPLC (acetonitrile - watei - 0 1% TFA, 20-100%) and crystallization from ethanol - water gave the title compound (50 mg, 20%) IH NMR (400 MHz, DMSO-d6) δ ppml3 11 (s, 1 H), 10.11 (s, 1 H), 7 79 (s, 1 H), 7 74 (d, J=l 58 Hz, 1 H), 7 66 (d, J=8.34 Hz, 1 H), 7.55 (t, .J=7.71 Hz, 1 H), 7.29 - 7 35 (m, 4 H), 7 23 - 7 29 (m, 1 H), 5 07 (s, 2 H), 5 03 (s, 2 H), 4 14(d,J=5 81 Hz, 2H). Example 12 (Formula Removed) N-r(6-Hvdroxy-2.4-dioxo-3-(phenylmethyl)-1 - {R-ftnfluoromethyUphenyllmethyl 1 -1.2,3,4-tetrahydro-5-pynmidinyl)carbonyllglvLine A mixture of ethyl 7v*-{[6-hydroxy-2,4-dioxo-3-(phenylmethyl)-l,2.3,4-tetrahydro-5-pyrimidinyl]carbonyl}glycinate (example 1 la. 356 mg, 1 03 mmoles), 4-tnfluoromethylbenzyl bromide (175 uL, 1 13 mmoles) and sodium carbonate (330 mg, 5 1 mmoles) in dimethylformamide (6.0 mL) was stirred under argon at 100°C for 2 5 hours The mixture was cooled, poured into 1 molar hydrochloric acid and extracted with ethyl acetate (x2). The ester was hydrolysed by stirring m a mixture of ethanol (3 mL) and 1 molar sodium hydroxide solution (3 mL) for 3 hours The mixture was acidified and extracted with ethyl acetate Purification by preparative HPLC (acetonitrile - water - 0 1% TFA, 20-100%) and crystallization from ethanol -water gave the title compound (150 mg, 30%) IH NMR (400 MHz, DMSO- Example 13 (Formula Removed) N- { [1 -[(3.4-DicatoTophenyl)methyn-6-hydro xy-2.4-dioxo-3-(phenylmethyl)-1,2.3.4-tetrahydro-5- pynmidmvllcarbonyl} glycine A mixture of ethyl N-{[6-hydroxy-2,4-dioxo-3-(phenylmethyB- l,2.3,4-tetrahydro-5-pyrimidmyl]carbonyl}glycinate (example 1 la, 357 mg, 1 03 mmoles), 3,4-dichlorobenzyl bromide (193 uL, 1.13 mmoles) and sodium carbonate (330 mg, 3.1 mmoles) m dimethylformamide (6 0 mL) was stirred under argon at 100°C for 2.5 hours. The mixture was cooled, poured into 1 molar hydrochloric acid and extracted with ethyl acetate (x2) The ester was hydrolysed by stirring m a mixture of ethanol (3 mL) and 1 molar sodium hydroxide solution (3 mL) for 3 hours. The mixture was acidified and extracted with ethyl acetate Purification by preparative HPLC (acetonitrile -water - 0.1% TFA, 20-100%) and crystallization from ethanol - water gave the title compound (50 mg, 10%). 1HNMR(400 MHz, DMSO-d6) δ ppm 13 13 (s, 1 H), 10 11 (t. J=5 68 Hz, 1 H), 7 59 (dd, J-5.18, 3.16 Hz, 2 H), 7 24 - 7 34 (m, 6 H), 5 01 (s, 2 H), 5.02 (s, 2 H), 4 14 (d, J=5 81 Hz, 2 H) Example 14 (Formula Removed) N-{[6-Hvdroxy-l-lf3-fmethyloxy>phenyl]methyn-2.4-dioxo-3-('phenylmethyl)-1.2.3.4-tetrahydro- 5-pyrimidmyl]carbonyl \ glycine A mixture of ethyl N-{[6-hydroxy-2,4-dioxo-3-(phenylmethyl)-l ,2,3,4-tetrahydro-5-pynmidinyl]carbonyl}glycinate (example 11a, 369 mg, 1 06 mmoles), 3-methoxybenzyl bromide (163 uL, 1 17 mmoles) and sodium carbonate (330 mg, 3 1 mmoles) in dimethylformamide (6.0 mL) was stirred under argon at 100°C for 2 5 hours The mixture was cooled, poured into 1 molar hydrochloric acid and extracted with ethyl acetate (x2) The ester was hydrolysed by stirring in a mixture of ethanol (3 mL) and 1 molar sodium hydroxide solution (3 mL) for 3 hours. The mixture was acidified and extracted with ethyl acetate Purification by preparative HPLC (acetonitrile -water - 0.1% TFA, 20-100%) and crystallization from ethanol - water gave the title compound (50 mg, 11 %) 1H NMR (400 MHz, DMSO-d6) δ ppm 13 10 (br s , 1 H). 10.12 (t, 1 H), 7 14 - 7.47 (m, 6 H), 6 69 - 6.97 (m, 3 H), 5 00 (s, 2 H), 5 03 is, 2 H), 4 13 (d, J=5 56 Hz, 2 H), 3 71 (s, 3 H) Example 15 (Formula Removed) N- {fl -[(2,6-Dichlorophenyl)methyn-6-hydroxy-2.4-dioxo-3-(phenylmethyl)-1,2,3,4-tetrahydro-5- pyrimidmyllcarbonyl I glycine A mixture of ethyl N-{[6-hydroxy-2.4-dioxo-3-(phenylmethyl)-l,2.3,4-tetrahydro-5 pynmidmyl]carbonyl}glycinate (example 11a, 388 mg, 1.12 mmoles), 2,6-dichlorobenzyl bromide (295 uL, 1 23 mmoles) and sodium carbonate (330 mg, 3 1 mmoles) in dimethylformainide (6 0 mL) was stirred under argon at 100°C for 2 5 hours The mixture was cooled, poured into 1 molar hydrochloric acid and extracted with ethyl acetate (x2) The ester was hydrolysed by stirring in a mixture of ethanol (3 mL) and 1 molar sodium hydroxide solution (3 mL) for 3 hours The mixture was acidified and extracted with ethyl acetate Purification by preparative HPLC (acetomtrile -water - 0.1% TFA, 20-100%) and crystallization from ethanol - water gave the title compound (60 mg, 11%). 1H NMR (400 MHz, DMSO-d6) δ ppm 13 12 (br s , 1 H), 10 02 (br s., 1 H), 7 42 (d. 2H), 7 22-7 35 (m, 6 H), 5 30 (s, 2 H), 5 01 (s. 2 H), 4 12 (d, .J=5 81 Hz, 2 H) Example 16 (Formula Removed) N-{r6-Hvdroxy-l-methyl-2.4-dioxo-3-(phenylmethyl)-1.2.3.4-tetrahydro-5-pyrrmidrnyl]carbonyl} glycine A mixture of ethyl N-{[6-hydroxy-2,4-dioxo-3-(phenylmethyl)-l ,2,3,4-tetrahydro-5-pyrimidmyl]carbonyl}glycinate (295 mg, 0 85 mmoles), methyl iodide (62 uL, 1 0 mmoles) and sodium carbonate (320 mg, 3 0 mmoles) in dimethylformamide (5 0 mL) was stirred under argon at 100°C for 2.5 hours. The mixture was cooled, poured into 1 molar hydrochloric acid and extracted with ethyl acetate (x2) The ester was hydrolysed by stirring in a mixture of ethanol (5 mL) and 1 molar sodium hydroxide solution (4 mL) for 4 hours The mixture was acidified and extracted with ethyl acetate. Purification by preparative HPLC (acetomtnle - water - 0 1% TFA, 20-100%) and crystallization from ether-hexane gave the title compound (80 mg, 28%) 1H NMR (400 MHz, DMSO-d6) δ ppm 13 11 (br. s., 1 H), 10.09 (br. s , 1 H), 7 28 - 7 36 (m, 4 H), 7 19 - 7.29 (m, 1 H), 5 01 (s, 2 H), 4 14 (d, J=5.81 Hz, 2 H), 3 21 (s, 3 H) Example 17 (Formula Removed) N- {T1 -Cyctohexyl-3-(2-cvclopropylethyl)-6-hydroxy-2,4-dioxo-1.2,3.4-tetrahydro-5-pynmidmyllcarbonvU glycine 17a) N-Cyclohexyl-.N-(2-cvclopropylethyl)urea Cyclohexyl isocyanate (564 uL, 4 7 mmoles) was added to a solution of cyclopropylethylamine hydrochloride (537 mg, 4 4 mmolesl and tnethylamme (615 uL, 4 4 mmoles) in chloroform (10 mL) under argon at room temperature The mixture was stirred for 1 hour, washed with 1 molar hydrochloric acid, dried and evaporated Trituration with hexane gave a solid (550 mg, 59%) 1H NMR (400 MHz, CHLOROFORM-rf) δ ppm 4 55 (br. s , 1 H), 3 47 - 3 59 (m, 1 H), } 27 (t, J=6 95 Hz, 2 H), 1 95 (dd, J=12 63, 3 54 Hz, 2 H), 1.67 - 1 79 (m, 2 H), 1.58 - 1 67 (m, 1 H), 1 43 (q, J=6 99 Hz, 2 H), 1 30 - 1 40 (m, 2 H), 1.07 -1 24 (m, 3 H), 0.63 - 0.77 (m, 1 H), 0 44 - 0 51 (m, 2 H). 0 05 - 0 12 (m, 2 Hj 17b) 1 -Cyck>hexyl-3-(2-cyclopropylethyl)-2.4,6( 1H,.3H.5H)-pynmidrnetrione. Malonyl dichloride (250 uL, 2 57 mmoles) was added dropwise to a solution of 7vr-cyclohexyl-A/'-(2-cyclopropylethyl)urea (500 mg, 2.38 mmoles) in dichloromethane under argon The mixture was stirred overnight then heated under reflux for 2 hours Flash chromatography (hexane to 20% ethyl acetate - hexane) gave the title compound (230 mg, 35%) 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 4 57 - 4 71 (m, 1 H), 3 94 - 4 04 (m, 2 H), i 60 - 3 68 (m, 2 H), 2 20 - 2 36 (m, 2 H), 1 86 (d, J=13 39 Hz, 2 H), 1.60- 1 73 (m, 3 H), 1 45 - 1 60 (m, 2 H), 1 29 - 1 44 (m, 2 H), 1 15- 1 29 (m, 1 H), 0 62 - 0 77 (m, 1 H), 0 40 - 0 51 (m, 2 H), -0.00 - 0 12 (m, 2 H) 17c) N-(ri-cyclohexyl-3-r2-cvclopropylethyl)-6-hydroxy-2,4-dioxo-1.2.3,4-terjrahydro-5-pyrimidinyllcarbonyl}glycine. A solution of l-cyclohexyl-3-(2-cyclopropylethyl)-2,4,6(1H,3H,5H) -pyrimidmetrione (225 mg, 0 8 mmoles) and dusopropylethylamine (280 uL, 1 6 mmoles) in chloroform (10 mL) was treated with ethyl 2-isocyanatoacetate (91 uL, 0.81 mmoles) and stirred for 1 hour The mixture was washed with hydrochloric acid (x2) and evaporated The residue was dissolved in ethanol (3 mL) and treated with 1 molar sodium hydroxide solution and stirred for 3 hours. The mixture was partitioned between ethyl acetate and 1 molar hydrochloric acid, separated and the organic solution washed with brme, dned and evaporated. The solid residue was reprecipitated from ether-hexane to give the title compound (190 mg, 63%) 1H NMR (400 MHz, DMSO-d6) δ ppm 13 07 (br. s, 1 H), 10 14 (t, .J=5 81 Hz, 1 H), 4 64 (s, 1 H), 4 12 (d, .J=5 81 Hz, 2 H), 3 87 - 3.92 (m, 2 H), 2 22 - 2 34 (m, 2 H), 1 79 (d, .J=13 14 Hz, 2 H), 1 61 (t,J=12 13 Hz, 3 H), 1 45 (q, J=7 16 Hz, 2 H), 1 23 - 1.33 (m, 2 H), 1 08 - 1 18 (m, 1 H). 0 62 - 0 70 (m, 1 H), 0 35 - 0 40 (m, 2 H). -0 04 - 0.00 (m, 2 H) Example 18 (Formula Removed) N-\(\ .3-Dicvclohexyl-6-hydroxy-2.4-dioxo-1,23.4-tetrahydro-5-pynmidinyl)carbonyl"|glvcme Method 1 18.1a) 1.3-Dicyclohexyl-2,4,6(1H,3H,5H)-pyrimidmetnone Dicyclohexylurea (3 0 g, 13 39 mmoles) was stirred in chloroform (80 mL) and treated with a solution of malonyl dichlonde (1 3 mL, 13 39 mmoles) in chloroform (20 mL), added dropwise under argon The mixture was heated at 50°C for 4 hours, wasahed with 1 molar hydrochloric acid and evaporated onto silica gel Flash chromatography (10-30% ethyl acetate in hexane) to give the title compound (2.13 g, 55%) 1H NMR(400MHz,DMSO-d6) δ ppm4 46(tt,.J=12 13,3 54 Hz, 2 H), 3 69 (s, 2 H), 2 15 (qd, .J=12 46, 3.28 Hz, 4 H), 1.77(d.J=13 14 Hz, 4 H), 1 59 (t.,J=12 76 Hz, 6 H), 1 26 (q, .J=12 97 Hz, 4 H), 1 04 - 1 16 (m, 2 H) 18.1b) N-[(1,3-Dicvclohexyl-6~hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)carbony 11 glycine. Ethyl isocyanatoacetate (802 uL, 7 15 mmoles) was added to a mixture of l,3-dicyclohexyl-2,4,6(1H,3H,5H)-pynmidmetnone (2 1 g, 7 15 mmoles) and diisopropylethylamme (2.47 mL, 14.3 mmoles) in dichloromethane (100 mL) and stirred overnight The reaction mixture was washed with 1 molar hydrochloric acid (x2) and evaporated. The residue was dissolved in ethanol (10 mL) and treated with 1 0 molar sodium hydroxide (5 mL) The mixture was stirred for 72 hours, acidified and extracted mto ethyl acetate Some ester remained, therefore the solution was evaporated and ther residue was dissolved in 1 molar soldium hydroxide solution with wanning and strred for 2 hours The mixture was acidified with 1M HC1 and extracted with ethyl acetate (x2) The combined extracts were washed with 1 molar hydrochloric acid , dried and evaporated to a solid which was slurried in a mixture of diethyl ether and hexane, collected, washed with the same solvent mixture and dried to give the title compound (1 86 g, 66%). 1H NMR (400 MHz, DMSO-d6) δ ppm 13 07 (br. s , 1 H), 10 19 (t, .J=5 31 Hz, 1 H), 4 63 (t, J=10 99 Hz, 2 H), 4 12 (d, J=5.56 Hz, 2 H), 2 27 (q, J=H 71 Hz,4H), 1.79 (d, J=12 88 Hz, 4 H), 1 50 - 1.69 (m, 6 H), 1.28 (q,J=12 97 Hz, 4 H), 1 12 (q,J=12 72 Hz, 2 H) Method 2 18.2a) 1.3-Dievcloaexyl-2.4.6( 1H13H,5H)-pynmidrnetnone A solution of M,N-dicyelohexylcarbodiimide (254 g, 1 23 mol) m anhydrous THF (700 mL) was added dropwise to a cold (0 °C) solution of malonic acid (64 1 g, 0 616 mol) in anhydrous THF (300 mL) over a penod of- 30 minutes. The mixture was stirred and allowed to warm to room temperature over 2 h (After 1 h, the mixture became very thick with precipitate so further anhydrous THF (500 mL) was added to facilitate agitation.). The mixture was filtered and the filtrate evaporated to afford a yellow solid which was immediately slurried m ethanol (1 L) and heated to reflux temperature The mixture was then allowed to cool to room temperature then filtered and the solid washed with cold ethanol (250 mL) to afford the title compound (129 4 g; 72%) as a colorless solid 1H NMR (400 MHz, DMSO-d6) δ ppm 1 03 - 1 18 (m, 2 H) 1 18 - 1 34 (m, 4 H) 1 59 (t, J=13 14 Hz, 6 H) 1 76 (d, J=12 88 Hz, 4 H) 2.04 - 2 24 (m, 4 H) 3 69 (s, 2 H) 4 35 - 4 54 (m, 2 H) 18.2b) Ethyl N-IYl.3-dicvclohexyl-6-hydroxy-2,4-dioxo-1.2,3.4-tetrahydro-5-pyrimidinyl)carbQnyl]glvcinate A solution of 1,3-dicyclohexyl-2.4,6( lH.3H,5H)-pyrimidinetrione (120 0 g; 0.41 mol) and diisopropylethylamine (105 8 g; 0 82 mol) in dichloromethane (1 L) was stirred and treated dropwise with a solution of ethyl isocyanatoacetate (53 0 g, 0 41 mol) in dichloromethane (500 mL) and the mixture was then stirred at room temperature overnight The mixture was then treated dropwise with 6M aq hydrochloric acid (500 mL) and the separated organic layer was dried and evaporated The resulting solid was slurried in hexanes (500 mL) and heated to reflux temperature The mixture was then allowed to cool and filtered to afford ethyl N-[(1,3-dicyclohexyl~6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pynmidmyl)carbonyl]glycinate (159.1 g, 92%) as a cream powder 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 1 24 (s, 2 H) 1.37 (s, 7 H) 1 52 - 1 76 (m, 6 H) 1 78 - 1 94 (m, 4 H) 2.25 - 2 48 (m. 4 Hj 4 17 (d,J=5 81 Hz, 2 H) 4 28 (q, J=7 24 Hz, 2 H) 4.74 (s, 2 H) 10 37 (t, J=4 67 Hz, 1 H) 18.2c) N-f(1.3-Dkvclohexyl-6-hydroxy-2,4-dioxo-1.23.4-tetrahydro-5- pyrimidinvDcarbopyllglycine A stirred suspension of ethyl N-[( 1,3-dicyclohexyl-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pynmidinyl)carbonyl]glycinate (159 0 g, 0 377 mol) m ethanol (1.5 L) was treated dropwise with 6M aq. Sodium hydroxide (250 mL) and stirred at room temperature for 3 h. The solution was then acidified by the dropwise addition of 6M aq hydrochlonc acid (300 mL), diluted with water (1L) and then filtered The crude solid was slurried in water (2 L) then stirred vigorously and heated at 35 °C for 1 h and filtered and dried The solid material (~ 138 g) was then crystallized from glacial acetic acid (1.5 L) (with hot filtration to remove a small amount of insoluble material). The solid, which crystallized upon cooling, was collected and washed with cold glacial acetic acid (3 x 100 mL) to affordN-[(l,3-dicyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pynmidinyl)carbonyl]glycine (116 2 g, 78%) as a colorless solid 1H NMR (400 MHz, DMSO-d6) δ ppm 1.11 (d, J=12 88 Hz, 2 H) 1 27 (q, J=12 80 Hz, 4 H) 1 62 (s, 6 H) 1 70 -1 90(m,J=12.88Hz,4H)2.11 - 2.44 (m, 4 H) 4 11 (d,J=5 81 Hz, 2 H) 4 45 - 4 77 (m, 2 H) 10 19 (t,J=5 81 Hz, 1 H) 13 08(s, 1 H) Example 14 (Formula Removed) N- (ri-Hexyl-6-hydroxy-2.4-dioxo-3-(phenylmethyl)-1,2.3.4-tetrahydro-5-pynmidinyl]carbonyll glycine 19a) N-Hexyl-N-(phenylmethyl)urea. «-Hexyl isocyanate (620 uL, 4 24 mmoles) was added to a solution of benzylamine hydrochloride (610 mg, 4 24 mmoles) and dusopropylethylamme (735 uL, 4.24 mmoles) in chloroform (10 mL) The mixture was stirred for 1 hour, washed with 1 molar hydrochloric acid (x2), dried and evaporated to give the title compound (993 mg, 91%) 1H NMR (400 MHz, CHLOROFORM-rf) δ ppm 7 18 - 7 45 (m, 5 H), 4 37 (s, 2 H), 3 15 (1, J=7 20 Hz, 2 H), 1.42-1 53 (m, 2 H), 1.23 - 1.36 (m, 6 H), 0.84 - 0 94 (m, 3 H). 19b) 1 -Hexyl-3-(phenylmethyl)-2,4,6( 1 #.3H,5.ffl-pynmidinetrione Malonyl dichloride (411 uL, 4.2 mmoles) was added to a solution of N-hexyl-N-(phenylmethyl)urea (900 mg, 3 8 mmoles) in dichloromethane (25 mL) and the mixture was heated under reflux for 3 hours The mixture was washed with 1 molar hydrochlonc acid and evaporated Flash cliromatography (10-15% ethyl acetate m hexane) gave the title compound (480 mg, 42%) 1H NMR (400 MHz, CHLOROFORM-*/) δ ppm 7.46 (dd, J=l 83, 1 52 Hz. 2 H), 7 28 - 7 41 (m, 3 H), 5.07 (s, 2 H), 3.82 - 3 91 (m, 2 H), 3.70 (s, 2 H), 1 52 - 1 66 (m. 2 H), 1 19 1 38 (m, b H), 0 79 - 0 97 (m, 3 H) 19c) N- {[1 -Hexyl-6-hydroxy-2.4-dioxo-3-(phenylmethyl)-1„2,3,4-tetrahydro-5-pyrimidinyncarbonyl} glycine. A mixture of 1 -hexyl-3-(phenylmethyl)-2,4,6(lH,3H,5H)-pyrimidinetrione (470 mg, 1 55 mmoles), dusopropylethylamme (280 uL, 1 6 mmoles) and ethyl 2-lsocyanatoacetate (132 uL, 1.55 mmoles) was stirred in chloroform (10 mL) for 3 hours. The mixture was washed with hydrochloric acid (x2) and evaporated The residue was dissolved m ethanol (15 mL), treated with 1 molar sodium hydroxide solution and stirred for 4 hours The mixture was partitioned between ethyl acetate and 1 molar hydrochloric acid The aqueous was extracted with ethyl acetate and the combined extracts washed with 1 molar hydrochloric acid and brine, dried and evaporated A solid was obtained from diethyl ether - hexane and recrystallized from toluene-hexane to give the title compound (280 mg, 46%) 1H NMR (400 MHz, DMSO-d6) δ ppm 13 11 (s, 1 H), 10 10 (s. 1 H), 7 24 - 7 34 (m, 5 H), 5.01 (s, 2 H), 4 13 (d, .J=5 81 Hz, 2 H), 3.77 - 3 86 (m, 2 H), 1 54 Example 20 (Formula Removed) N- (fl -^thyl-6-hydroxy-2.4-dioxo-3-(phenylmethyl)-1.2.3.4-tetrahydro-5-pynmidmvncarbonyl} glycine 20a) l-Ethyl-3-(phenylmethylV2.4.6(1H,3H,5H)-pyTimidmetnone. Malonyl dichlonde (411 uL, 4.2 mmoles) was added to a solution of N-ethyl-N-(phenylmethyl)urea (685 mg, 3 84 mmoles) in dichloromethane (25 mL) and the mixture was heated under reflux for 1 hour The mixture was washed with 1 molar hydrochloric acid and evaporated. Flash chromatography (10-30% ethyl acetate in hexane) gave the title compound (390 mg, 42%) 1H NMR (400 MHz, CHLOROFORM-**) δ ppm 7 41 - 7 49 (m, 2 H), 7 25 - 7 34 (m, 3 H). 5 03 (s, 2 H), 3 92 (q, J=7 07 Hz, 2 H), 3 64 (s, 2 H), 1.20 (t, J=H 07 Hz, 3 H) 20b) N-(ri-Ethyl-6-hydroxy-2.4-dioxo-3-(phenylmethyn-1.2.3.4-tetrahydro-5-pyrimidinyllcarbonyllglycine. A solution of l-ethyl-3-(pheny]methyl)-2,4,6(1H.3/f,5.rY> pyrimidmetnone (390 mg, 1.58 mmoles) and dusopropylethylamme (546 uL, 3 16 mmoles) in chloroform (10 mL) was treated with ethyl isocyanatoacetate (135 uL, 1 58 mmoles) and stirred for 2 hours under argon. The mixture was washed with 1 molar hydrochloric acid (x2), dried and evaporated The residue was dissolved m ethanol (10 mL), treated with 1 molar sodium hydroxide solution (5 mL) and stirred overnight. The mixture was acidified and extracted into ethyl acetate and the organic solution dried and evaporated Crystallization from methanol - water gave the title compound (350 mg, 64%). 1H NMR (400 MHz, DMSO-J6) δ ppm 13 12 (br s. 1 H), 10 10 (s, 1 H), 7.24 - 7 35 (m, 5 H), 5.01 (s, 2 H), 4 14 (d,J=5 56 Hz, 2 H), 3 87 (q, J=6 99 Hz, 2 H), 1 14 (t, J=6.95 Hz, 3 H) Example 21 (Formula Removed) N-{[6~Hydroxy-2.4-dioxo-3-(phenylmethyD-l -propyl-1,2,3,4-tetrahydrp-5-pynmidinyllcarbonyl \ glycine 21a) 1 -(Phenvtoethyl)-3-Dropyl-2.4,6( 1H,3fl,5H)-pynmidinetrione Malonyl dichlonde (427 uL, 4 4 mmoles) was added to a solution of N-(phenylmethyl)-7V,-propylurea (778 mg, 4 04 mmoles) m dichloromethane (25 mL) and the mixture was heated under reflux for 1 hour The mixture was washed with 1 molar hydrochloric acid and evaporated Flash chromatography (10-20% ethyl acetate m hexane) gave the title compound (730 mg, 70%) 1H NMR (400 MHz CHLOROFORM-d) δ ppm 7 46 (dd, J=8 08, 1 52 Hz, 2 H), 7 29 - 7 38 (m, 3 H), 5.07 (s, 2 H). 3 79 - 3 87 (m, 2 H), 3.69 (s, 2 H), 1 57 - 1 69 (m. 2 H). 0 94 (t, J=7 45 Hz, 3 H) 21b) 7Y- {r6-HvdrQXV-2.4-dioxo-3-fphenylmethylV 1 -propyl-1.2.3.4-tetrahydro-S-pyrimidinyllcarbonyl)glycine. A solution of 1 (phenylmethyl)-3-propyl-2,4,6(1H,3/f,5/i)-pynmidinetnone (730 mg, 2.8 mmoles) and dnsopropylethylamine (970 uL, 5 6 mmoles) in chloroform (12 mL) was treated with ethyl isocyanatoaeetate (239 uL, 2 8 mmoles) and stirred for 2 hours under argon The mixture was washed with 1 molar hydrochloric acid (x2), dried and evaporated. The residue was dissolved m ethanol (10 mL), treated with 1 molar sodium hydroxide solution (5 mL) and stirred overnight The mixture was acidified and extracted into ethyl acetate and the organic solution dried and evaporated Crystallization from ethanol - water gave the title compound (800 mg, 71%) 1H NMR (400 MHz, DMSO-rf6) δ ppm 13 11 (s, 1 H), 10 11 (s, 1 H), 7 24 - 7 34 (m, 5 H), 5.01 (s, 2 H), 4 13 (d, J=5 81 Hz, 2 H), 3 75 - 3 84 (m, 2 H), 1 52 - 1 63 (m, 2 H), 0 86 (t, J=7.45 Hz, 3 H) (Formula Removed) N-^ri-Butyl-6-hydroxy-2.4-dioxQ-3-(phenylmethyl)-l,2J14-tetrahydro-5-pynmidinyllcarbonyl} glycine 22a) 1 ~Buryl-3-fphepyl;ffiethyr)-2.4.6( lH,3H,5H)-pyrimidmetnone Malonyl dichlonde (497 uL, 5.1 mmoles) was added to a solution of A-butyl-A"~(phenyimetriyl)urea (959 mg, 4.65 mmoles) m dichloTomethane (25 rnL) and the mixture was heated under reflux for 1 hour. The mixture was washed with 1 molar hydrochloric acid and evaporated. Flash chromatography (0-15% ethyl acetate m hexane) gave the title compound (676 mg, 53%; 1H NMR (400 MHz, DMSO-d6) δ ppm 7 29 - 7.35 (m, 4 H), 7 20 - 7.28 (m, 1 H), 4 92 (s, 2 H). 3 X2 (s, 2 H). 3 71 (t, 2 H), 1 48 (tt, 2 H), 1.28 (tq,J=7.49, 7.33 Hz, 2 H), 0 88 (Formula Removed) N~ j[6-Hydroxy-2.4-dioxo-1 -(2-phenylethyl )-3-(phenylmethyl)-1,2,3,4-tetrahydro-5- pynmidmyl jcarbony 1 \ glycine 43 23a) N-(2-Phenylethyl)-N-(phenylmethyi)urea Phenethyl isocyanate (612 uL, 4 42 mmoles) was added to a stirred solution of benzylamine hydrochloride (635 mg, 4 42 mmoles) and diisopropylamme (766 uL, 4 42 mmoles) in chloroform under argon and stirred for 1 hour The mixture was washed with 1 molar hydrochloric acid (x2), dried and evaporated to give the title compound (1 0 g, 89%). IH NMR (400 MHz, CHLOROFORMd) δ ppm 7 20 - 7 41 (m, 8 H), 7.18 (d, .J=6.82 Hz, 2 H), 4.34 (s, 1 H), 3 47 (t, .J=6 82 Hz, 2 H), 2 82 (t, J=6 95 Hz, 2 H) 23b) l-(2-Phenylethyl)-3-(phenylmethylV2.4.6(lH,3H.5H)-pynmidmetnone Malonyl dichlonde (546 uL, 5 6 mmoles) was added to a solution ofN-(2~phenylethyl)-A"-(phenylmethyl)urea (1 0 g, 3 93 mmoles) m dichloromethane (25 mL) and the mixture was heated under reflux for 1 hour. The mixture was washed with 1 molar hydrochloric acid and evaporated Flash chromatography (10-25% ethyl acetate m hexane) gave the title compound (930 mg, 73%) IH NMR (400 MHz, CHLOROFORM-ci) δ ppm 7 43 (dd, J=7 9b, 1 64 Hz, 2 H). 7 14 - 7 40 (m, 8 H), 5 06 (s, 2 H), 4.08 - 4 17 (m, 2 H), 3 64 (s, 2 H), 2 87 - 2 97 Example 24 (Formula Removed) N- {[3- ([4-( 1.1 -Dimethylethyl)phenyllmethyl} -6-hydroxy-1 -(1 -methylethyl )-2,4-dioxo-1,2,3.4- tetrahydro-5-pynmidmvllcarbonyl} glycine 24a)1 - (f4-( 1.1-Dimethylethyl)phenyllmethyl) -3-( 1 -methylethyl)-2.4.6( IH.3H.5H)-pyrimidinetnone. A mixture of 4-t-butylben2ylamme (704 uL, 4 0 mmoles) and isopropyl isocyanate (392 uL, 4.0 mmoles) was stirred in chloroform (10 mL) for 1 hour Malonyl dichlonde (388 uL, 4 0 mmoles) was added and the mixture was heated at 45"C for 1 hour The mixture was washed with 1 molar hydrochloric acid and purified by flash chromatography (10-25% ethyl acetate - hexane) to give the title compound (385 mg, 30%) 1H NMR (400 MHz, CHLOROFORM-d6) δ ppm 7 34 - 7 43 (m, 4 H), 5 03 - 5 09 (m, 1 H), 5 03 (s, 2 H), 3 66 (s, 2 H), 1 45 (d, J=l 07 Hz, 6 H), 1 32 (s, 9 H) 24b) N-{f3-{[4-(l.l-dimethylethynphenyllmethyU-6-hydroxy-l-(l-methylethylV2.4-dioxo-1.2.3.4-tetrahyuro-5-pyrimidinyl1carbonyll glycine A solution of l-J,[4-( 1,1-dimethylethyl)phenyl]methyl}-3-(l-methylethyl)-2,4,6(l^,3H,5j¥)-pynmidinetnone (385 mg, 1 21 mmoles) and diisopropylethylamine (418 uL, 2 42 mmoles) in chloroform (10 mL) was treated with ethyl isocyanatoacetate (103 uL, 1 21 mmoles) and stirred for 3 hours under argon The mixture was washed with 1 molar hydrochloric acid (x2), dried and evaporated The residue was dissolved in ethanol (5 mL), treated with 1 molar sodium hydroxide solution (8 mL) and stirred for 3 hours The mixture was acidified and extracted into ethyl acetate and the organic solution dried and evaporated A solid was obtained by trituration m hexane plus a little diethyl ether, collected, washed with hexane to give the title compound (338 mg, 67%). IH NMR (400 MHz, DMSO-J6) δ ppm 13 09 (br.s, 1 H), 10 12 (br.s, 1 H), 7 34 (d, J=8 34 Hz, 2 H), 7 22 id, J=8 59 Hz, 2 H), 5 06 (ddd, J=13 52, 6.69, 6 57 Hz, 1 H), 4 96 (s, 2 H), 4 13 (d, .J=5.81 Hz, 2 H), 1 41 (d, .J=7 07 Hz, 6 H), 1 25 (s, 9 H) Example 25 (Formula Removed) N-|"(l-cyclohexyl-3-{r4-(l.l-dimethylethyl)phenyl]methyll-6-hydroxy-2.4-dioxo-1.2.3.4-tetrahydro-5-pynmidinyl)carbonyllglycine 25a) 1 -Cyclohexyl-3-{[4-( 1.1 -dimethylethyl)Dhenyl1methyll -2.4.6( 1 H.3H.5H)-pyrimidinetnone. A mixture of 4-r-butylbenzylamine (880 uL, 5 0 mmoles) and cyclohexyl isocyanate (638 uL, 5.0 mmoles) was stirred in dichloromethane (40 mlj for 1 hour Malonyl dichlonde (388 uL, 4.0 mmoles) was added and the mixture was heated under gentle reflux for 1 hour. The mixture was washed with 1 molar hydrochlonc acid and purified by flash chromatography (10-25% ethyl acetate - hexane) to give the title compound (1 23 g, 69%) 1H NMR (400 MHz, CHLOROFORM-rf) δ ppm 7 33 - 7 43 (m, 4 H), 5 02 (s, 2 H), 4 56 - 4 70 (m, 1 H), 3.65 (s, 2 H), 2 20 - 2 35 (m, 2 H), 1 85 (d, .J=13 39 Hz, 2 H), 1 65 (t, J=16 42 Hz, 3 H), 1 20 -1.43 (m, 11 H) 25b) N-H1 -Cyelohexyl-3-{[4-(l. 1 -dimethylethyl)phenyllmethyl} -6-hydroxy-2.4-dioxo-1.2.3.4-tetrahydro-5-pyriiaidjnyl)carbonyllglvcine A solution l-cyclohexyl-3-{[4-(l,l-dimethylethyl)phenyl]methyl}-2,4,6(1H,3H,5H)-pynmidmetrione (1 23 g, 3 45 mmoles) and diisopropylethylamine (1 2 mL, 6.9 mmoles) in chloroform (20 mL) was treated with ethyl isocyanatoacetate (295 uL, 3 45 mmoles) and stirred overnight under argon. The mixture was washed with 1 molar hydrochlonc acid (x2), dned and evaporated The residue was dissolved in ethanol (8 mL), treated with 1 molar sodium hydroxide solution (8 mL) and stirred for 3 hours The mixture was diluted with ethyl acetate, washed with 1 molar hydrochlonc acid (x2), dried and evaporated A solid was obtained from ethanol - water to give the title compound (1 3 g, 82%) lHNMR(400MHz, DMSO-d6) δ ppm 13 10 (br s, 1 H), 10 14(br s, 1 H), 7 34 (d, J=8 34 Hz, 2 H), 7.22 (d, J=8.34 Hz, 2 H). 4 95 (s, 2 H), 4 65 (t, J=1 1 75 Hz, 1 H). 4 13 (d, J=5.81 Hz, 2 H), 2 14 - 2 37 (m, 2 H), 1.79 (d, J=12.63 Hz, 2 H), 1 62 (d, J=11 62 Hz, 3 H), 1 19 - 1 37 (m, 11 H), 104-1 19 (m, 1 H) Example 26 (Formula Removed) N-{r6-Hvdroxy-1.3-bis(l-methylethyl)-2.4-dioxo-1.2.3.4-tetrahydrQ-5-pynmidmyllcarbonyl) glycine 26a) 1.3-Bis(l-methylethyl)-2.4.6(1H.3H,5H)-pynmidmetnone A solution of isopropylamine (520 uL, 6 11 mmoles) was stirred in dichloromethane (25 mL) under nitrogen, treated with isopropyl isocyanate (600 uL, 6.11 mmoles) m dichloromethane (25 mL) and stirred for 1 hour Malonyl dichloride (593 uL, 6 11 mmoles) was added and the mixture was heated under gentle reflux for 1 hour. The mixture was washed with 1 molar hydrochloric acid and punfied by flash chromatography (10-30% ethyl acetate - hexane) to give the title compound (900 mg, 69%) 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 5 04 (dt, J=\3 89, 6 95 Hz, 2 H), 3 61 (s, 2 H), 1 45 (d,J=7 07Hz, 12 H) 26b) N-{r6-Hvdroxy-1.3-bisfl-methylethyl)-2.4-dioxo-l,2.3,4-tetrahydro-5-pyriimdinvHcarbopyHglycine A solution l,3-bis(l-methylethyl)-2,4,6(1H,3H,5H)-pynmidmetnone (900 mg, 4.24 mmoles) and diisopropylethylamine (1 47 mL, 8 48 mmoles) in chloroform (15 mL) was treated with ethyl isocyanatoacetate (362 uL, 4 24 mmoles) and stirred for 4 hours under nitrogen The mixture was washed with 1 molar hydrochloric acid (x2), dried and evaporated The residue was dissolved in ethanol (6 mL), treated with 1 molar sodium hydroxide solution (8 mL) and stirred overnight. The mixture was diluted with ethyl acetate, washed with 1 molar hydrochloric acid (x2), dried and evaporated to a solid that crystallized from diethyl ether -hexane to give the title compound (925 mg, 69%) 1 H NMR (400 MHz, DMSO-de) δ ppm 13 06 (s, 1H), 10.14 (t,J=5.81 Hz, 1 H), 4 98-5 09 (m, 2 H), 4 12(d,.J=5 81 Hz, 2 H), 1 39 (d, .J=6 82 Hz, 12 H) Example 27 (Formula Removed) N- ir3-ff2-Bromophenyl)methyn-1 -f 1.1 -dimethylethyl)-6-hydroxy-2.4-dioxo-1.2,3.4-tetrahydro-5- pynmidinyl]carbonyl} glycine 27a) 1 -fq-Bromophenvr)methyl1-3-(1, 1 -dimethylethyl)-2,4,6(1H,3H,5H)-pyTimidinetnone t-Butyl isocyanate (571 uL, 5 0 mmoles) was added to a solution of 2-bromobenzylamine hydrochloride (1.112 g, 5 0 mmoles) and diisopropylethylamine (864 uL, 5 0 mmoles) in chloroform (50 mL) and the mixture stirred for 1 hour Malonyl dichlonde (486 uL, 5 0 mmoles) was added and the mixture was stirred at 50°C for 1 hour The mixture was washed with 1 molar hydrochloric acid and evaporated. Flash chromatography (10-35% ethyl acetate - hexane) afforded the title compound (500 mg, 28%) 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 7.59 (dd, J=8.08, 1 26 Hz, 1 H), 7.26 - 7 32 (m, 1 H), 7 12 - 7.19 (m, 1 H), 6 99 (dd, J=7 58, 1 52 Hz, 1 H), 5 12 (s, 2 H), 3 72 (s, 2 H), 1 63 (s, 9 H) 27b) N-1 r3-IY2-Bromophenyl)methyH-1 -(1,1 -dimethylethyl )-6-hydroxy-2.4-dioxo-1.2,3,4-tefrahydro-5-pyrimidinvricarbonyl) glycine 1 -[(2-Bromophenyl)methyl]-3-( 1,1 -dimethylethyl)-2,4,6(1H,3H,5H)-pyTraildinetrione (500 mg, 1.41 mmoles) and diisopropylethylamine (490 uL, 2.82 mmoles) were stared together in dry chloroform (15 mL) and treated with ethyl isocyanatoacetate (121 uL, 1 41 mmoles) The mixture was stirred for 3 hours, washed twice with 1 molar hydrochloric acid, dried and evaporated. The residue was dissolved in ethanol (5 0 mL) and treated with 1 molar sodium hydroxide solution (6.0 mL)) and stirred overnight The mixture was partitioned between ethyl acetate and 1 molar hydrochloric acid, the organic solution washed with 1 molar hydrochloric acid, dried and evaporated The title compound was obtained by crystallization from ethanol-water (390 mg, 61 %) 1H NMR (400 MHz, DMSO-d6) δ ppm 13 08 (s, 1 H). 10 05 (s, 1 H), 7 65 (dd, .J=8.08, 1 01 Hz, 1 H), 7.34 (t,J=6.95 Hz, 1 H), 7.22 (td, J=7 71, 1 52 Hz, 1 H), 7.03 (d, J=6.57 Hz, 1 H), 4 96 (s, 2 H), 4 12 (d, J=5 81 Hz, 2 H), 1 66 (s, 9 H) Example 28 (Formula Removed) N-[( 1 -f2.6-Dichlorophenyl)-3- {[4-( 1.1 -dimethylethyl)phenyllmethyl \ -6-hydroxy-2,4-dioxo-1.2.3.4-tetrahydro-5-pyrimidinyl)carbonyllglycine 28a) 1 -C2-6-DichloroDhenyl)-3- \ \4-( 1.1 -dimethylethyl (phenyl 1 methyl} -2.4.6(W.3H.5H)-pyrimidmetrione. A mixture of 2,6-dichlorophenhsocyanate (1 47 g, 7.82 mmoles) and 4-f-butylbenzylamme (1 38 g, 7 82 mmoles) in dichloromethane (100 mL) was stirred under argon for 1 hour Malonyl dichloride (760 uL, 7 82 mmoles) was added and the mixture was heated at 40°C for 1 hour. The mixture was washed with 1 molar hydrochlonc acid and evaporated Flash chromatography (10-25% ethyl acetate - hexane) afforded the title compound (2 2 g, 67%) 1H NMR (400 MHz, CHLOROFORM-rf) S ppm 7 50 (d, J=\ 26 Hz, 1 H), 7 48 (d, J=0 51 Hz, 2 H), 7.35 - 7 41 (m, 5 H), 5.11 (s, 2 H), 3 92 (s. 2 H), 1 33 (s, 9 H) 28b) N-IY1 -(2.6-Dichlorophenyl)-3-{[4-( 1,1 -dimethylethyl)phenyllmethyl 1 -6-hydroxy-2.4-dioxo-1.2,3,4-tetrahydro-5-pyrimidmvl)carbonyl1glycine l-(2,6-DichlorophenyI)-3-{[4-(l,l-dimethylethyl)phenyl]methyl}-2,4,6(lW,3H,5H)-pyrimidmetrione (2 3 g, 5 48 mmoles) and diisopropylethylamine (1 9 mL, 10 97 mmoles) were stirred together in dry chloroform (50 mL) and treated with ethyl isocyanatoacetate (469 uL. 5 48 mmoles) The mixture was stirred overnight, washed twice with 1 molar hydrochlonc acid, dried and evaporated Flash chromatography (dichloromethane) gave pure ester which was dissolved in ethanol (10 mL) and treated with 6 molar sodium hydroxide solution (5 0 mL)) and stirred overnight The mixture was partitioned between ethyl acetate and 1 molar hydrochloric acid, the organic solution washed with 1 molar hydrochloric acid, dried and evaporated The title compound was obtained by crystallization from ethanoi-water (1.8 g, 63%) IH NMR (400 MHz, DMSO-4.) § ppm 13.20 (s, 1 H), 10 08 (s, 1 H), 7.67 - 7.74 (m, 2 H), 7 54 - 7 61 (m, 1 H), 7.37 (d, J=8 34 Hz, 2 H), 7.22 (d, J"=8 59 Hz, 2 H), 5.06 (s, 2 H), 4 15 (d, .J=5.56 Hz, 2 H), 1 26 (s, 9 H) Example 29 (Formula Removed) N-[ (1 -(2.4-dichloxophenyl)-3- {[4-( 1.1 -dimethylethyl)phenyl]methy 1} -6-hydroxy -2t4-dioxo-1.2.3.4- tetrahydro-5-pyrirnidmyl)carbonyl]glycine 29a) 1 -( 2.4-Piehlorophenyl)-3- ([ 4-( 1.1 -drmethylethyl)phenyl Imethyl I -2A.60.H3H5H)-pyrimidinetnone. A mixture of 2,4-dichlorophenhsocyanate (1 43 g. 7 6 mmoles} and 4-t-butylbenzylamine (1.34 ml, 7.6 mmoles) m dichloromethane (100 mL) was stirred under argon for 1 hour Malonyl dichloride (739 uL, 7 6 mmoles) was added and the mixture was heated at 40"C for 1 hour. The mixture was washed with 1 molar hydrochloric acid and evaporated Flash chromatography (10-25% ethyl acetate - hexane) afforded the title compound (2 6 g, 82%) IH NMR (400 MHz, CHLOROFORM-**) δ ppm 7.58 (d, J~2 27 Hz, 1 H), 7.35 - 7 43 (m, 5 H). 7.21 (d, J=8.59 Hz, 1 H), 5 10 - 5 17 (m, 1 H), 5.01 - 5 07 (m. 1 H), 3 89 Hz, 1 H), 7 56 - 7.68 (m, 2 H), 7.62 (none, 2 H), 7 36 (d, 2 H), 7 26 (d, J=8 59 Hz, 2 H), 5 02 (d, J=2.27 Hz, 2 H), 4.15 (d,J=5 81 Hz, 2 H), 1 26 (s, 9 H) Example 30 (Formula Removed) N-Ul -(2-BromophenvD-3- (f4-(l. 1 -dimethylethyQphenyllmethyl} -6-hydroxy-2.4-dioxo-1.2,3.4- tetrahydro-5-pyrimidinyl)carbonyllglvcine 30a) l-(2-BromophenylV3-(f4-(l.l-dimethylethyl)phenynmethyl,]-2.4.6(lJrY.3i/.5H)-pyrimidinetnone. A mixture of 2-bromophenyhsocyanate (1 11 g, 5 6 mmoles) and 4-t-butylbenzylamine (1 0 ml, 5 6 mmoles) in dichloromethane (100 mL) was stirred under argon for 2 hours. Malonyl dichlonde (739 uL, 7 6 mmoles) was added and the mixture was heated at 40°C for 3 hour. The mixture was washed with 1 molar hydrochloric acid and evaporated Flash chromatography (10-35% ethyl acetate - hexane) afforded the title compound (1 75 g, 72%) 1H NMR (400 MHz, CHLOROFORM-rf) δ ppm 7 74 (dd, 7-7 96, 1 39 Hz, 1 H), 7 47 (td, J=7.71, 1 52 Hz, 1 H), 7.41 - 7 44 (m, 2 H), 7 35 - 7 40 (m, 3 H). 7 28 (dd. J=7 83, 1 77 Hz, 1 H), 5 11-5 18 (m, I H), 5.02 - 5 09 (m, 1 H), 3.90 (d, J=6 57 Hz, 2 H), 1 33 (s, 9 H) 30b) N-\( l-(2-Bromophenyl)-3- (f4-( 1. l-dimethylethyl)phenyllmethyl}-6-hydrQxy-2.4-dioxo-l,2.3.4-terrahydro-5-pyruaidmvl)carbonynglvcine l-(2-Bromophenyl)-3-{[4-(l,l-dimethylethyl)phenyl]methyl}-2,4,6(1H,3i:/,5H)-pynmidinetrione (1 7 g, 3 96 mmoles) and dnsopropylethylamine (1.37 mL, 7 92 mmoles) were stirred together in dry dichloromethane (20 mL) and treated with ethyl isocyanatoacetate (338 uL, 3 96 mmoles) The mixture was stirred for 4 hours, washed twice with 1 molar hydrochloric acid, dried and evaporated. The residue was dissolved in ethanol (10 mL) and treated with 1 molar sodium hydroxide solution (6 0 mL) and stirred overnight. The mixture was partitioned between ethyl acetate and 1 molar hydrochloric acid, the organic solution washed with 1 molar hydrochloric acid, dried and evaporated to a foam. The title compound was obtained as a solid by trituration with hexane and standing overnight (1.3 mg, 62%). 1H NMR (400 MHz, DMSO- Example 31 (Formula Removed) N-U1 -r2-BiphenylvlV3- i [4-( 1.1 -dimethylethyl)phenyllmethyl 1 -6-hydroxy-2.4-dioxo-1.2.3.4- tettahydrQ-5-pynmidmvl)carbonyl1glvcine 31a) l-(2-BiDhenylvn-3-(r4-(l.l-dimethylethyl)phenyllmethyll-2.4.6(lH,3H.5H)-pynmidinetnone. A mixture of 2-biphenyhsocyanate (858 uL, 5 0 mmoles) and 4-t-butylbenzylamine (881 uL, 5.0 mmoles) in dichloromethane (50 mL) was stirred under argon overnight Malonyl dichloride (486 uL, 5 0 mmoles) was added and the mixture was heated at 40°C for 3 hours. The mixture was washed with 1 molar hydrochlonc acid and evaporated Flash chromatography (10-35% ethyl acetate - hexane) afforded the title compound as a gum (1 86 g, 87%) 1H NMR (400 MHz, DMSO-d6) δ ppm 7 48-757 (m, 2 H), 7 44 (dd, J=7 07, 2 02 Hz, 1 H), 7.30 - 7.41 (m, 4 H), 7.26 (d, J=8 34 Hz, 2 H), 7 13 (d..J=6 82 Hz, 2 H), 6 89 (d, J=8 08 Hz, 2 H), 4 74 - 4.85 (m, 2 H), 3 92 (s, 2 H), 1.28 (s, 9 H) 31b) N-Ul -(2-Biphenylvl)-3- {\4-( 1,1 -dimethylethyl)phenyllmethyl \ -6-hydroxy-2,4-dioxo-1.2.3.4-tetrahydro-5-pyrimidmyl)carbonyllglycme l-(2-Biphenylyl)-3-{[4-(l,l-dimethylethyl)phenyl]methyl}-2,4,6(1H,3H,5H)-pynmidmetrione (1 8 g, 4 22 mmoles) and diisopropylethylamine (730 uL, 4 22 mmoles) were stirred together in dry dichloromethane (50 mL) and treated with ethyl isocyanatoacetate (474 uL, 4 22 mmoles) The mixture was stirred for under argon overnight, washed twice with 1 molar hydrochlonc acid, dried and evaporated The residue was dissolved m ethanol (10 mL) and treated with 1 molar sodium hydroxide solution (1.0 mL) and 6 molar sodium hydroxide solution (2 0 mL) and stirred for 24 hours The mixture was partitioned between ethyl acetate and 1 molar hydrochlonc acid, the organic solution washed with 1 molar hydrochlonc acid, dried and evaporated The title compound was obtained as a solid by tnturation with a small amount of dichloromethane in hexane (1 3 mg, 58%) 1H NMR (400 MHz, DMSO-d6)8ppml3 09(br s, 1 H), 10 01 (t, .J=5 68 Hz, 1 H), 7 49 7 58 (m, 2 H), 7 41 -7.47 (m, 1 H), 7.26 - 7 37 (m, 5 H). 7 15 (d. J=6 57 Hz, 2 H), 6 89 (d, J=8 08 Hz. 2 H), 4 89 (s, 2 H), 4 11 (d, J=5 81 Hz, 2 H), 1 28 (s, 9 H) Example 32 (Formula Removed) N- {[6-Hvdroxy-2.4-dioxo-3-(phenvrmethyiy 1 -(tetrahydTo-2Jj-pyran-4-vl)-1.2.3.4-tetrahydro-5- pynmidinyllcarbonyl 1 glycine 32a) 1 -(Phenylmethyl)-3-(ftetrahydro-2.H-pyTan-4-vn-2,4.6(IH.3H.5H) pynmidinetnone. A mixture of tetrahydro-2H-pyTan-4-ylamme (400 mg, 3 96 mmoles) and benzyl isocyanatc (490 uL, 3.96 mmoles) in chloroform (40 mL) was stirred under inert atmosphere for 4 hours. Malonyl dichloride (388 uL, 4 0 mmoles) was added and the mixture was heated at 50°C for 3 hours. The mixture was washed with 1 molar hydrochloric acid and evaporated Flash chromatography (10-40% ethyl acetate - hexane) afforded the title (980 mg, 82%) 1H NMR (400 MHz, DMSO-ds) δ ppm 7 23 - 7.35 (m, 5 H), 4 91 (s, 2 H), 4 69 - 4 79 (m, .J=12 06, 12.06, 3 92, 3 79 Hz, 1 H), 3 91 (dd, J=ll 12, 4 29 Hz, 2 H), 3 82 (s, 2 H), 3 33 (t, J=l 1 12 Hz, 2 H), 2 41 (qd,,J=12.38, 4 55 Hz, 2 H), 1 49 (dd, J=12 00, 2 15 Hz, 2 H) 32b) N-{f6-Hydroxy-2.4-dioxo-3-(Dhenylmethyl)-l-(tetrahydro-2H-pyran-4-vl)-l.2.3.4-tetrahydro-5 -pyrirnidinyllcarbonyl} glycine 1 -(Phenylmethyi)-3-(tetrahydro-2H-pyran-4-yl)~ 2,4,6(IH,3H,5H) pynmidinetnone (970 mg, 3 21 mmoles) and dnsopropylethylamine (111 mL, 6.42 mmoles) were stirred together in dry dichioromethane (50 mL) and treated with ethyl isocyanatoacetate (360 uL, 3 21 mmoles) The mixture was stirred for under argon overnight, washed twice with 1 molar hydrochlonc acid, dned and evaporated. The residue was dissolved in ethanol (15 mL) and treated with 1 molar sodium hydroxide solution (2 0 mL) and 6 molar sodium hydroxide solution (2.0 mL) and stirred for 4 hours The mixture was partitioned between ethyl acetate and 1 molar hydrochlonc acid, the organic solution washed with 1 molar hydrochlonc acid, dned and evaporated to a solid The solid was triturated with diethyl ether, collected, washed with a small amount of diethyl ether and hexane to afford the title compound (1 05 g, 81 %) IH NMR (400 MHz, DMSO-d6) δ ppm 13.11 (br s, I H), 10 15 It, .7-4 93 Hz, 1 H). 7 24 - 7 35 (m, 5 H), 5 00(s,2H),4.86-4 96(m,J=ll 91, 11 91,3 85,3 66 Hz. 1 H). 4 14 (d, .J=5 81 Hz, 2 H), 3.93 (dd, J=l 1 12, 4 04 Hz, 2 H), 3 37 (d, J=\ I 37 Hz, 2 H). 3 32 (s, 1 H), 2 53 - 2 59 (m 1 H), 1 55 (d, J=10 36Hz, 2H) Example 33 (Formula Removed) N-{[3-Cycloh9xyl-6-hydroxy-2.4-dioxo-l-(tetrahydro-2H-pyran-4-vl)-l. 2.3.4- tetrahydro-5- pynmidmyllearbonyl I glycine 33a) l-Cyclohexyl-3-(tetrahydro-2H-pyran-4-vl)-2.4.6(1H.3H,5H)-pynmidmetrione A mixture of tetrahydro-2H-pyran-4-ylamine (400 mg, 3 96 mmoles) and cyclohexyl isocyanate (505 uL, 3 96 mmoles) m chloroform (40 mL) was stirred under inert atmosphere for 4 hours. Malonyl dichloride (388 uL, 4 0 mmoles) was added and the mixture was heated at 50°C for 3 hours The mixture was washed with 1 molar hydrochloric acid and evaporated Flash chromatography (10-35% ethyl acetate - hexane) afforded the title (900 mg, 77%) 1H NMR (400 MHz, DMSO d6) δ ppm4 72(tt,J=12 09,3 95Hz, 1 H), 4 42-451 (m,.J=12 16, 12 16, 3 60, 1 41 Hz. 1 H), 391 (dd, J=1 1 12, 4 29 Hz, 2 H), 3.70 (s, 2 H), 3 33 (t, J- 10 99 Hz, 3 H), 2 42 (qd, J=12 38, 4 80 Hz, 2 H), 2.15(qd,J=12 51,3 41 Hz, 2 H), 1 77 (d, J=13 14 Hz. 2 H), 1.55- 1 65 (m, 3 H), 1 48 (dd, J=11 87, 2.27 Hz, 2 H), 1.21 - 1 32(m,2H), 1 12 (tt, J=12 S5, 3 06 Hz, 1 H) 33b) N- {r3-Cyclohexyl-6-hydroxy-2.4-dioxo-1 -(tetrahydro-2H-pyran-4-vl)-1,2,3.4-tetrahydro-5-pyrimidinyllcarbonvUelvcme l-Cyclohexyl-3-(tetrahydro-2H-pyran-4-yl)-2,4,6(1H,3i7,5H)-pyrimidinetnone (900 mg, 3.06 mmoles) and dusopropylethylamine (1.06 mL, 6 12 mmoles) were stirred together in dry dichloromethane (50 mL) and treated with ethyl isocyanatoacetate (360 uL, 3.21 mmoles). The mixture was stirred for under argon overnight, washed twice with 1 molar hydrochloric acid, dried and evaporated The residue was dissolved in ethanol (15 mL) and treated with 1 molar sodium hydroxide solution (2 0 mL) and 6 molar sodium hydroxide solution (2 0 mL) and stirred for 4 hours. The mixture was partitioned between ethyl acetate and 1 molar hydrochloric acid, the organic solution washed with 1 molar hydrochloric acid, dried and evaporated to a solid. The solid was triturated with diethyl ether, collected, washed with a small amount of diethyl ether and hexane to afford the title compound (570 mg, 47%) 1H NMR (400 MHz, DMSO-4) δ ppm 13 10 (br s, 1 H), 10 19 (t, ,J=5 56 Hz, 1 H), 4 83 - 4 94 (m. 1 H), 4 63 (t, .J=11 49 Hz, 1 H), 4 13 (d, J=5 81 Hz, 2 H), 3 93 (dd, J=11 12, 4 04 Hz, 2 H) 3 30 - 3 37 (m, 2 H), 2 56 (m, 2 H), 2 21 - 2.33 (m, 2 H), 1 79 (d, J=12 88 Hz, 2 H), 1 61 is, 3 H), I 52 (d, J=10 61 Hz, 2 H), 1.28 (q, J=12.97 Hz, 2 H), 1 11-1 18 (m. 1 H) Example 34 (Formula Removed) N-{r3-(r4-(l.l-Dimethylethyl')phenyllmethyl]-6-hydroxy-2,4-dioxo-l-(2-thieovn-l,2,3,4-tetrahydro-5-pynmidinyllcarbonyll glycine 34a) l-{r4-(l.l-DimethylethynDhenynmethyl}-3-(2-thienylV2.4,6(1H.3/f.5J7)-pyrimidmetnone. A mixture of 2-thienyl isocyanate (970 mg, 7 76 mmoles) and 4-t-butylbenzylamine (1 38 mL, 7 76 mmoles) in dichloromethane (100 mL) was stirred under inert atmosphere for 2 hours Malonyl dichloride (754 uL, 7 76 mmoles) was added (became dark on addition) and the mixture was heated under reflux for 1 5 hours The mixture was washed with 1 molar hydrochloric acid and evaporated Flash chromatography (10-35% ethyl acetate - hexane) afforded the title (274 mg, 10%) 1H NMR (400 MHz, DMSO-J6) δ ppm 7 57 (dd, .J=5 56, 1 52 Hz, 1 H), 7 27 - 7.36 (m, 4 H), 7 04 (dd, J=5 43, 3 66 Hz, 1 H), 6 96 (dd, J=3 66, I 39 Hz, 1 H), 4 90 (s, 2 H), 3 94 (s, 2 H), 1 26 (s, 9 H) 34b) N-{r3-ir4-(l.l-Dimethylethynr>henyllmethyU-6-hydroxy-2,4-dioxo-l-(2-thienyl)-1.23.4-tetrahydro-5-Dyrimidinyncarbonyn glycine 1 - {[4-( 1,1 -Dimethylethyl)phenyljmethyl} -3-(2-thienyl)-2,4,6(1H,3^r,5H)-pyrimidmetnone (270 mg, 0 66 mmoles) and dnsopropylethylamine (228 uL, 1.32 mmoles) were stirred together in dry chloroform (5 mL) and treated with ethyl isocyanatoacetate (56 4 uL, 0.66 mmoles) The mixture was stirred under argon overnight, washed twice with 1 molar hydrochloric acid, dried and evaporated The residue was dissolved m ethanol (5 mL) and treated with 6 molar sodium hydroxide solution (1.5 mL) and stirred overnight. The mixture was partitioned between ethyl acetate and 1 molar hydrochloric acid, the organic solution washed with 1 molar hydrochloric acid and evaporated, taken up in diethyl ether and warmed with decolorizing charcoal. The mixture was filtered and evaporated to a foam The sohd was triturated with hexane and collected. Preparative HPLC (10-100% acetonitrile - water -0 1% TFA) gave the title compound (120 mg, 40%). 1H NMR (400 MHz, DMSO-tf6) δ ppm 13 15 (br s, 1 H), 10 09 (br. s, 1 H), 7.60 (dd, J=5 05, 1 77 Hz, 1 H), i 32 - 7 38 (m, 2 H), 7.26 7 31 (m, 2 H), 7 04 - 7 10 (m, 2 H), 4 98 (s, 2 H), 4 12 - 4 19 (m, 2 H), 1 26 (s 9 H) Example 35 (Formula Removed) N-(n-Cyclohexyl-6-hydroxy-3-r3-(4-morpholmvl)propyll-2,4-dioxo-1,2,3,4-tetrahydro-5- pynmidiny 11 carbonyl) glycine 35a) 1 -Cyelohexyl-3-r3-(4-morpholinyl)propyn-2,4.6( 1 //,3H.5H)-pynmidinetrione A mixture of cyclohexyl isocyanate (638 mg, 5 0 mmoles) and 3-morphohnopropylamme (730 mL. 5.0 mmoles) m dichloromethane (50 mL) was stirred under inert atmosphere for 3 hours Malonyl dichloride (486 uL, 5 0 mmoles) was added and the mixture was heated under reflux for 3 hours The mixture was washed with water, sodium bicarbonate solution and evaporated Flash chromatography (0-5% methanol - dichloromethane) afforded the title (785 mg, 47%) 35b) N-({ l-Cyclohexyl-6-hydroxy-3-r3-(4-morpholmvl)propyl1-2.4-dioxo-1.2.3.4- tetrahydro-5-pyrimidinyl\carbonvDglvcine. l-Cyclohexyl-3-[3-(4-morpholinyl)propyl]-2,4,6(1H,3H,5H)-pyrimidmetnone (785 mg, 2.32 mmoles) and dnsopropylethylamme (805 uL, 4 65 mmoles) were stirred together in dry dichloromethane (50 mL) and treated with ethyl isocyanatoacetate (260 uL, 2.32 mmoles). The mixture was stirred under argon overnight, washed with water and brine, dried and evaporated. The residue was dissolved in ethanol (10 mL) and treated with 1 molar sodium hydroxide solution (2.0 mL) and 6 molar sodium hydroxide solution (1 0 mL) and stirred for 2 hours The mixture was diluted with 1 molar hydrochloric acid and extracted with ethyl acetate (x3), the organic solution washed with bnne and evaporated The residue was purified by preparative HPLC (10-70% acetonitnle - water - 0 1%TFA) to give the title compound (90 mg, 9%) 1H NMR (400 MHz, DMSO- Example 36 (Formula Removed) N-H3- (f4-( 1.1-Dimethylethyl)phenynmethyl} -6-hydroxy-2.4-dioxo-1 -(3-pyndinyl)-1.2.3.4-tetrahydro-5-pynmidinyllcarbonyl} glycine 36a) l-{r4-(l.l-DimethylethynphenynmethyU-3-(3-Dyndinyn-2.4.6riH.3H.5H)-pynmidmetnone. A mixture of pyridine 3-isocyanate (622 mg, 5 18 mmoles) and 4-t-butylbenzylamine (912 uL, 5 18 mmoles) in dichloromethane (50 mL) was stirred overnight The urea was purified by flash chromatography (ethyl acetate), taken up m methoxyethanol (10 mL), treated with diethyl malonate (1.0 mL, 6 58 mmoles) and sodium ethoxide (1 0 mL of a 21 molar solution in ethanol) and heated under reflux for 24 hours in an inert atmosphere The mixture was cooled, diluted with ethyl acetate and washed with brine The organic solution was evaporated and purified by flash chromatography (10-100% ethyl acetate in hexane) to give the title compound (340 mg, 19%) IH NMR (400 MHz, DMSO-J6) δ ppm 8.62 (dd, J=4 80, 1 52 Hz, 1 H), 8 48 (d, J=2.02 Hz, 1 H), 7 75 (d, J==8 08 Hz, 1 H), 7 57 (dd, 7-8 21, 4 93 Hz, 1 H), 7 29 - 7 36 (m, 4 H), 3.55 (s, 2 H), 1 26 (s, 9 H) 36b) N- (r3-iT4-(l .1 -Dimethylethyl)phenynmethyll -6-hydroxy-2.4-dioxo-1 -(3-pyndinylV 1.2.3.4-tetrahydro-5-pyrimidinyl1carbonyl} glycine 1 - {[4-( 1, l-Dimethylethyl)pherryl]methyl}-3-(3-pyridmyl)-2,4,6(1H,3.r7,5H)-pyrimidinetrione (340 mg, 0.96 mmoles) and dhsopropylethylamine (334 uL, 1 93 mmoles) were stirred together in dry chloroform(25 mL) and treated with ethyl isocyanatoacetate (108 uL, 0 96 mmoles) The mixture was stirred under argon overnight, washed with 1 molar hydrochloric acid and brine, dried and evaporated The residue was dissolved in ethanol (5 mL) and treated with 1 molar sodium hydroxide solution (2 0 ml.) and 6 molar sodium hydroxide solution (2 0 mL) and stirred overnight The mixture was diluted with 1 molar hydrochloric acid and extracted with ethyl acetate (x2), the organic solution washed with brine and evaporated. The solid residue was slurried in hot ethanol, collected and recrystalhzed from ethanol - water to give the title compound (100 mg, 23%) 1H NMR (400 MHz, DMSO-d6) δ ppm 13.11 (s, 1 H), 10.09 (s, 1 H), 8 62 (dd, J=467, I 39 Hz, 1 H), 8 58 (s, 1 H), 7 86 (d, J=7 83 Hz, 1 H), 7 55 (dd,.J=8 08, 4 80 Hz, 1 H). 7 28 - 7 37 (m. 4 H), 5 00 (s, 2 H), 4 11 - 4 19 (m, 2 H), 1 26 (s, 9 H) Example 37 (Formula Removed) N-( {1 -Cyelohexyl-3-f(2-fluorophenyl)methyH-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5- pyrrmidmyUcarbonyllglvcine 37a) Ethyl N-\l\ -Cyclohexyl-6-hydroxy-2.4-dioxo-1.2.3.4-tetrahydro-5-p^midmvDcaybonyllelvcuiate. Ethyl isocyanatoacetate (9 7 mL, 86 32 mmoles) in dichloromethane (80 mL) was added dropwise to a stirred solution of 1 -cyclohexylpyrimidinetrione (16 5 g, 78 5 mmoles) and dusopropylethylamine (27 2 mL, 157 mmoles) in dichloromethane (120 mL) The mixture was stirred for 3 hours, 1 molar hydrochloric acid was added, causing the title compound to precipitate The solid was collected and washed with 1 molar hydrochloric acid. The solid was slurried in diethyl ether, collected, washed with diethyl ether and hexane then dried to give the title compound (23 g, 86%) IH NMR (400 MHz, DMSO- Example 38 (Formula Removed) N-((3-r(2-Cblorophenyl')methyn-l-Cyclohexyl-6-hydroxy-2,4-dioxo-1.2.3.4-tetrahydro-5- pynmidmyl tcarbonyl Iglyeine A mixture of ethyl N-[( 1 -cyclohexyl-6-hydroxy~2,4-dioxo-1,2.3,4-tetrahydro-5-pynmidmyI)carbonyl]glycmate (340 mg, 1 0 mmoles),/>«/v Potassium carbonate (740 mg, 5 35 mmoles) and 2-chlorobenzyl bromide (300 mg, 1 5 mmoles) in dimethylformamide (5 mL) was vigorously stirred at 100°C for 3 hours The mixture was poured into 1 molar hydrochlonc acid and extracted with ethyl acetate The organic solution was washed with 1 molar hydrochlonc acid and evaporated The residue was purified by flash chromatograph}- (10-50% ethyl acetate m hexane), the required fractions evaporated, dissolved m ethanol (5 mL) and 1 molar sodium hydroxide solution (1 0 mL) and 6 molar sodium hydroxide solution (1 0 mL; added. The mixture was stirred overnight, acidified and extracted with ethyl acetate (x2), the combined extracts washed with 1 molar hydrochloric acid, dried and evaporated to give the title compound (193 mg, 44%) lHNMR(400MHz,DMSO- Example 39 (Formula Removed) N-(U-Cyclohexyl-6-hydroxy-2,4-dioxo-3-[(5,5,8,8-tetramethyl-5,6,7,8-tetTahydro-2- naphthalenyl)methyl]-1.2.3.4-tetrahydro-5-pynmidinvUcarbonyl)glvcme A mixture of ethyl N-[(l-cyclohexyl-6-hydroxy-2,4-dioxo-l ,2,3,4-tetrahydro-5-pyrimidmyl)carbonyl]glycinate (340 mg, 1 0 mmoles), puh Potassium carbonate (740 mg, 5 35 mmoles) and 6-(bromomethyl)-l,l,4,4-tetramethyl-l,2,3,4-tetrahydronaphthalene (250 mg, 0.89 mmoles) in dirnethylformamide (5 mL) was vigorously stirred at 100°C for 3 hours. The mixture was poured into 1 molar hydrochloric acid and extracted with ethyl acetate The organic solution was washed with 1 molar hydrochloric acid and evaporated The residue was purified by flash chromatography (10-50% ethyl acetate in hexane), the required fractions evaporated, dissolved in ethanol (5 mL) and 1 molar sodium hydroxide solution (1 0 mL) and 6 molar sodium hydroxide solution (1.0 mL) added The mixture was stirred overnight, acidified and extracted with ethyl acetate (x2), the combined extracts washed with 1 molar hydrochloric acid, dned and evaporated to give the title compound (156 mg, 35%). IH NMR (400 MHz, DMSO-d6) S ppm 13 07 (br s., 1 H), 7.24 (dd, .J=4.80, 3 28 Hz, 2 H), 6 98 (dd, J=8 21, 1 39 Hz, 1 H), 4 93 (s, 2 H), 4 66 (t, J=l 1 87 Hz, 1 H), 4 13 (d,y=5 56 Hz, 2 H), 2 19 - 2 36 (m, 2 H), 1 79 (d,.J=12 63 Hz, 2 H), 1.62 (s, 7 H), 1.01 - 1 37 (m, 15 H) Example 40 (Formula Removed) N-( {1 -Cyclohexyl-3-[(2.4-dimethylphenyl)methyll-6-hydroxy-2.4-dioxo-1,2.3.4-tetrahydro-5- pynmidinyl} carbonyl)glycine A mixture of ethyl N-[(l-cyclohexyl-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycinate (340 mg, 1 0 mmoles), pulv Potassium carbonate (740 mg, 5 35 mmoles) and 2,4-dimethylbenzyl bromide (400 mg, 2 0 mmoles) in dirnethylformamide (5 mL) was vigorously stirred at 100°C for 3 hours The mixture was poured into 1 molar hydrochloric acid and extracted with ethyl acetate The organic solution was washed with 1 molar hydrochloric acid and evaporated The residue was purified by flash chromatography (10-50% ethyl acetate in hexane), the required fractions evaporated, dissolved in ethanol (5 mL) and 1 molar sodium hydroxide solution (1.0 mL) and 6 molar sodium hydroxide solution (1 0 mL) added. The mixture was stirred overnight, acidified and extracted with ethyl acetate (x2), the combined extracts washed with 1 molar hydrochloric acid, dned and evaporated to give the title compound (173 mg, 40%) IH NMR (400 MHz, DMSO-4) δ ppm 13 10 (br s, 1 H), 10 15 (br s, 1 H).2 31 (s, 3 H), 2 18-2.29 (m, 5 H), 1.78 (d, J=13 14 Hz, 2 H), 1 62 (d, J=10 36 Hz, 3 H). 1 28 (q, J-12 72 Hz, 2 H), 1.12 (t, .J=12.88 Hz, 1 H). Example 41 (Formula Removed) N-( {1 -Cyclohexyl-6-hydroxy-2,4-dioxo-3-r(2,4,6-tnfluorophenyl)methyl)-1,2,3,4-tetrahydro-5- pynmidmyl [ carbonvPgrycine A mixture of ethyl N-[(l-cyclohexyl-6-hydroxy-2,4-dioxo-l ,2,3,4-tetrahydro-5-pynmidinyl)carbonyl]glycinate (340 mg, 1 0 mmoles), pulv Potassium carbonate (740 mg, 5 35 mmoles) and 2,4,6-trifluorobenzyl bromide (337 mg, 1 5 mmoles) in dimethylformamide (5 tnL) was vigorously stirred at 100°C for 3 hours The mixture was poured into 1 molar hydrochloric acid and extracted with ethyl acetate The organic solution was washed with 1 molar hydrochlonc acid and evaporated. The residue was punfied by flash chromatography (10-50% ethyl acetate in hexane), the required fractions evaporated, dissolved m ethanol (5 mi) and 1 molar sodium hydroxide solution (1.0 mL) and 6 molar sodium hydroxide solution (1 0 mL) added. The mixture was stirred overnight, acidified and extracted with ethyl acetate (x2), the combined extracts washed with 1 molar hydrochloric acid, dned and evaporated to give the title compound (240 mg, 53%) 1H NMR (400 MHz, DMSO-d6) δ ppm 13 06 Example 42 (Formula Removed) .N-[(l-Cyclohexyl-6-hydroxy-3- [[4-(l-methylethyl)phenyl]methyl}-2,4-dioxo-l,2,3,4-tetrahydro- 5 -pynmidmy l)carbony 1] glycine A mixture of ethyl N-[(l-cyclohexyl-6-hydroxy-2,4-dioxo-].2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycinate (340 mg, 1 0 mmoles), pulv Potassium carbonate (1.0 g, 7 24 mmoles) and 4-isopropylbenzyl chloride (250 mg, 1 5 mmoles) in dimethylacetamide (5 mL) was vigorously stirred at 100°C for 3 hours The mixture was poured into 1 molar hydrochloric acid and extracted with ethyl acetate The organic solution was washed with 1 molar hydrochloric acid and evaporated. The residue was purified by flash chromatography (10-50% ethyl acetate in hexane), the required fractions evaporated, dissolved in ethanol (5 mL) and 1 molar sodium hydroxide solution (1.0 mL) and 6 molar sodium hydroxide solution (1 0 mL) added. The mixture was stirred overnight, acidified and extracted with ethyl acetate (x2), the combined extracts washed with 1 molar hydrochloric acid, dried and evaporated to give the title compound (161 mg, 36%) 1H NMR (400 MHz, DMSO-d6) δ ppm 13 10 (s, 1 H), 10 14 (s, J H), 7 16 7 24 (m, 4 H), 4 95 (s, 2 H), 4.64 (t, J=l 1 37 Hz, 1 H), 4 13 (d, ,J=5 56 Hz, 2 H), 2 79 - 2 90 (m, J=6 86, 6.86, 6 86, 6 86, 6 86, 6 86 Hz, 1 H), 2.20 - 2 32 (m, 2 H), 1 78 (d, J=12 88 Hz, 2 H), 1 62 id, .J=11 12 Hz, 3 H), 1 22 - 1 34 (m, 2 H), 1 09 - 1 20 (m, 7 H) Example 43 (Formula Removed) N-({l-Cyclohexyl-3-[(2-ethylphenyl)methyl]-6-hydroxy-2,4~dioxo-l,2,3,4-tetrahydro-5- pynmidmyl J carbonyl)glycinc A mixture of ethyl N-[(l-cyclohexyl-6-hydroxy-2,4-dio\o-l ,2,3,4-tetrahydro-5-pyrimidmyl)carbonyl]glycinate (680 mg, 2 0 mmoles), puh potassium carbonate (2 0 g, 14 46 mmoles) and a mixture of both 2- and 4-ethylbenzyl chlonde (4o4 mg, 3 0 mmoles) m dimethylacetamide (8.0 mL) was vigorously stirred at 100°C for 3 hours The mixture was poured into 1 molar hydrochloric acid and extracted with ethyl acetate The organic solution was washed with 1 molar hydrochloric acid and evaporated. The residue was separated by preparative HPLC (80% acetonitrile-water-0 1%TFA), to give a) ethyl N-{ j l-cyclohexyl-3-[(2-efhytphenyl)methyl]-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pynmidinyl}carbonyl)glycrnate (100 mg, 11%) and b) ethyl N-({l-cyclohexyl-3-[(4-ethylphenyl)methyi]-6-hydroxy-2,4-dioxo-1,2,3,4- tetrahydro-5-pynmidinyl}carbonyl)glycinate (300 mg, 33%) Product a) was dissolved in ethanol (5 mL) and 1 molar sodium hydroxide solution (1 0 mL) and 6 molar sodium hydroxide solution (1 0 ml-) added The mixture was stirred overnight, acidified and extracted with ethyl acetate (x2), the combined extracts washed with 1 molar hydrochloric acid, dried and evaporated to give the title compound (58 mg, 62%) 1HNMR(400 MHz, DMSO-d6) δ ppm 13 00 (br s , 1 H), 10 15 (br s , 1 H), 7 14 - 7.23 (m, 2 H), 7.07 - 7 15 (m, 1 H), 6 88 (d, J=l 58 Hz, 1 H), 5 03 Is, 2 H), 4 65 (t, J=l 1 75 Hz, 1 H), 4 13 (d, J=5.56 Hz, 2 H), 2 72 (q, J=7 49 Hz, 2 H), 2 17 - 2.35 (m, 2 H). 1 78 (d, J=12 63 Hz, 2 H), 1.56 - 1.69 (m, 3 H), 1.23 - 1 35 (m, 2 H), 1 20 (t, J=7 58 Hz, 3 Hi, 1 04 - 1 17 (m, 1 H) Example 44 (Formula Removed) N-( {1 -Cyclohexyl-3-[(4-ethylphenyl)methyl]-6-hydroxy-2,4-dioxo-1.2,3,4-tetrahydro-5- pynmidmyl tcarbony ljglycine Ethyl N-( {1 -cyclohexyl-3-[(4-ethy lpheny l)methyl]-6~hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pynmidinyl}carbonyl)glycmate (product b from example 43) was dissolved in ethanol (5 mL) and 1 molar sodium hydroxide solution (1 0 mL) and 6 molar sodium hydroxide solution (1.0 mL) added The mixture was stirred overnight, acidified and extracted with ethyl acetate (x2), the combined extracts washed with 1 molar hydrochlonc acid, dried and evaporated to give the title compound (195 mg, 69%) 1H NMR (400 MHz, DMSO-d6) δ ppm 13 13 (br s , 1 H), 10 15 (s, 1 H), 7.18-7 24 (m, 2 H), 7.13-7 18 (m, 2 H), 4 95 (s, 2 H), 4 64 (t, 1=\ 1 62 Hz, 1 H), 4 13 (d, .J=5.81 Hz, 2 H), 2.56 (q, J=7 58 Hz, 2 H), 2 20-231 (m, 2 H), 1 78 (d.7-12 13 Hz, 2 H), 1 61 (d, J=10.36 Hz, 3 H), 1.28 (q, J= 12.72 Hz, 2 H), 1 06 - 1 17 (m, 4H) Example 45 (Formula Removed) N-({l-Cyclohexyl-6-hydroxy-2,4-dioxo-3-[(2,4.6-tnmethylphenyl)methyl]-l,2,3,4-tetrahydro-5- pynmidmyl | carbonyl)glycine A mixture of ethyl N-[(l-cyclohexyl-6-hydroxy-2,4-dio\o-l,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycinate (340 mg, 1 0 mmoles), pulv potassium carbonate (1 0 g, 7 24 mmoles) and 2,4,6-trimethylbenzyl chloride (339 mg, 1 5 mmoles) in dimethylacetamide (5 mL) was vigorously stirred at 100°C for 3 hours The mixture was poured into 1 molar hydrochlonc acid and extracted with ethyl acetate The organic solution was washed with 1 molar hydrochlonc acid and evaporated. The residue was punfied by flash chromatography (10-50% ethyl acetate in hexane), the required fractions evaporated, dissolved in ethanol (5 mL) and 1 molar sodium hydroxide solution (1 0 mL) and 6 molar sodium hydroxide solution (1 0 mL) added The mixture was stirred overnight, acidified and extracted with ethyl acetate (x2), the combined extracts washed with 1 molar hydrochlonc acid, dned and evaporated to give the title compound (61 mg, 13%) IH NMR (400 MHz, DMSO- Example 46 (Formula Removed) N-{[l-Cyclohexyl-3-(2-Cyclohexylethyl)-6-hydroxy-2,4-dioxo-1.2,3.4-tetrahydro-5- pynmidinyncarbonylj glycine A mixture of ethyl N-[(l-cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5 pyrimidmyl)carbonyl]glycinate (340 mg, 1 0 mmoles), puh potassium carbonate (1 0 g, 7 24 mmoles) and 2-cyclohexylethyl bromide (287 mg, 1 5 mmoles) m dimethylacetamide (8 mL) was vigorously stirred at 100°C for 3 hours The mixture was poured into 1 molar hydrochlonc acid and extracted with ethyl acetate The organic solution was washed with 1 molar hydrochloric acid and evaporated The residue was purified by flash chromatography (10-50% ethyl acetate in hexane), the required fractions evaporated, dissolved in ethanol (5 mL) and 1 molar sodium hydroxide solution (1.0 mL) and 6 molar sodium hydroxide solution (1 0 mL) added The mixture was stirred overnight, acidified and extracted with ethyl acetate (\2), the combined extracts washed with 1 molar hydrochloric acid, dned and evaporated Recrystalhzation from toluene gave the title compound (180 mg, 42%). 1H NMR (400 MHz, DMSO-d6) δ ppm 10 15 (br s , .J=5 43, 5 43 Hz, 1 H), 4 63 (t, J=11 62 Hz, 1 H), 4 07 - 4 19 (m, 2 H), 3 72 - 3.88 (in, 2 H), 2 18 2.36 (m, 2 H), 1 50 - 1 87 (m, 10 H), 1 35 - 1 47 (m, 2 H), 1 04 - 1 35 (m, 7 H), 0 91 (q, J=11 62 Hz, 2 H) Example 47 (Formula Removed) Nr[(3-{[3,5-Bisrmethyloxy^phenyllmethyn-l-Cyclohexyl-d-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro- 5-pyrirmdmyl (carbonyll glycine A mixture of ethyl N-[(l-cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycinate (340 mg, 1.0 mmoles), puh potassium carbonate (1 5 g, 11 mmoles) and 3,5-dimethoxybenzyl bromide (300 mg, 1 3 mmoles) in dimethylacetamide (5 mL) was vigorously stirred at 100°C for 3 hours The mixture was poured into 1 molar hydrochloric acid and extracted with ethyl acetate The organic solution was washed with 1 molar hydrochlonc acid and evaporated. The residue was purified by flash chromatography (10-50% ethyl acetate in hexane), the required fractions evaporated, dissolved m ethanol (5 mL) and 1 molar sodium hydroxide solution (1.0 mL) and 6 molar sodium hydroxide solution (1 0 mL) added The mixture was stirred overnight, acidified and extracted with ethyl acetate (x2), the combined extracts washed with 1 molar hydrochloric acid, dried and evaporated Recrystallization from toluene gave the title compound (190 mg, 41%) 1HNMR(400 MHz, DMSO-d6) δppm 13 11 (s, 1 H), 10 15 (s, 1 H), 6 40 (s, 3 H), 4 92 (s, 2 H), 4 64 (t, J=\ 1 87 Hz, 1 H), 4 09 - 4.17 (m, 2 H), 3 70 (s, 6 H), 2.26 (s, 2 H), 1 78 (d,.J=12.63 Hz, 2 H), 1 62 (d, J=l 1 62 Hz, 3 Hi. 1 28 (q, J=13 05 Hz, 2 H), 1.06 - 1 17 (m, 1 H) Example 48 (Formula Removed) N- (f 1 -Cyclohexyl-6-hydroxy-3-(2-naphthalenylmethyl)-2.4-dioxo-1.2.3.4-tetrahydro-5- pynmidmyllcarbonyl} glycine A mixture of ethyl N(3-cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycinate (100 mg, 0 29 tnmoles), 2-bromomethylnaphthalene (195 mg, 0 I mmoles) and polymer-bound 2-^rt-butyhmino-2-diethylamine-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine(pol-BEMP, 0.88 mmoles) in DMF (3 mL) was heated in a microwave synthesiser at 120°C for 20 mmutes After cooling, the mixture was filtered, and the solids washed with dichloromethane (3X3 mL) The combined filtrate was evaporated and purified by flash chromatography (ethyl acetate-hexane) to obtain the desired intermediate ester The crude ester was dissolved HI ethanol (4 mL) and 1M aqueous NaOH (1 mL) and the solution stirred for 2 hours, then neutralized by addition of 1M aqueous HC1 The solid was collected, washed with water (3X4 mL) and dned under vacuum overnight to give the title compound (77 mg, 29%) IH NMR (400 MHz, CDC13) δ ppm 1 13 - 1.42 (m, 4 H) 1 56 - 1 72 (m, 3 H) J 77 - 1.90 (m, 2 H) 2.26-2.44 (m, 2 H) 4.24 (dd, J=2 2, 5.7 Hz, 2 H) 4 64 - 4 84 (m, 1 H) 5.24 (s, 2 H) 7 40 - 7 50 (m, 2H)7 55(dt,J=2 1,8.3 Hz, 1 H) 7 75 - 7 90 (m, 4 H) 10 21 - 10.34 (m, 1 H) Example 49 (Formula Removed) N-( (1 -Cyclohexyl-6-hydroxy-3-r(4-methylphenyl)methyn-2,4-dioxo-1.2.3.4-tetrahydro-5~ pyrirnidmyl} carbonyl Iglvcine Using 4-methylbenzyl bromide in place of 2-bromomethylnaphthylene, the title compound was prepared in 27% yield (67 mg) following the procedures described m example 48. IH NMR (400 MHz, CDCI3) δ ppm 1.10 - 1 43 (m, 4 H) 1 52 - 1 72 (m, 3 H) 1 76 1 93 (m, 2 H) 2 20 - 2.43 (m, 5 H) 4 22 (dd, J=3 4, 5.7 Hz, 2 H) 4 64 - 4 82 (m, 1 H) 5 04 (s. 2 H) 7 06 - 7 16 (m, 2 H) 7 29 -7.36 (m, 2 H) 10.15 - 10.36 (m, 1 H) Example 50 (Formula Removed) N- {[3-f4-Biphenylyhnethyll-1 -cyclohexyl-6-hydroxy-2.4-dioxo-1,2.3.4~tetrahydro-5- pynmidinyllcarbonyl) glycine Using 4-bromomethylbiphenyl in place of 2-bromomethylnaphthylene, the title compound was prepared in 17% yield (48 mg) following the procedures described m example 48 IH NMR (400 MHz, CDCI3) δ ppm 1 13 - 1.45 (m, 3 H) 1 55 -1 75 (m, 3 H) 1 76 - 1 91 (m, 2 H) 2.24 - 2 46 (m, 2 H) 4.23 (dd, J=3 4, 5 7 Hz, 2 H) 4 62 - 4 92 (m, 1 H) 5 12 (s, 2 H) s 42 - 5 97 (m, 2 H) 7 29 -7 38(m, lH)738-746(m,2H)746-761 (m, 6 H) 10.14- 1042(m. 1 H) Example 51 (Formula Removed) {[3- {[4-(l ,3-Benzoxazol-2-yl')phenyllmethyl} -1 -Cyclohexyl-6-hydroxy-2,4-dioxo-1.2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]elvcinc Using 2-[4-(bromomethyl)phenyl]-l,3-bcnzoxazole in place of 2-bromomethylnaphthylene, the title compound was prepaied in ]0% yield (30 mg) following the procedures described m example 48 IH NMR (400 MHz, CDCIj) δ ppm 1 11 - (.42 (m, 3 H) 1 57 - 1 72 (m, 3 H) 1.74 - 1 91 (m, 2 H) 2.27 - 2 43 (m, 2 H) 4 16 (dd, J=3 4, 5 7 Hz, 2 H) 4 67-4 95 (m, 3 H) 5 09-5.23 (m, 2 H) 7 32-7 42 (m, 3 H) 7 53-7 62 (m. 3 H) 7 74-7 79 (m, 1 H) δ 38-8 27 (m, IH) 10 22-10 42 (m, 1 H) Exampte 52 (Formula Removed) N-f{3-r2-(4-Biphenylvl)-2-oxoethyll-l-Cyclohexyl-6-hydroxy-2.4-dioxo-l,2,3,4-tetrahydro-5- pynmidinyl} c arbonyl) glycine Using 2-bromo-4'-phenylacetophenone in place of 2-bromornethylnaphthylene, the title compound was prepared m 8% yield (24 mg) following the procedures descnbed in example 48 IH NMR (400 MHz, CDC13) δ ppm 1 11 - 1 27 (m, 1 H) 1 27 - 1 43 (m, 2 H) 1 59 - 1.78 (m. 3 H) 1 78- 1 20 (m, 2 H) 2 25 - 2.43 (m, 2 H) 4.15 -4 31 (m. 2 H) 4 62 - 4 87 (m, 1 H) 5 36 - 5 42 (m, 2 H) 7 39 -7 45 (m, 1 H) 7 45 - 7 53 (m, 2 Hi 7 61 - 7 67 |m. 2 H) 7 69 -7 76 (m, 2 H) δ 08 (d, J=8 3 Hz, 2 H) 10.07 - 10.42(m, 1 H) Example 53 (Formula Removed) N-[(1.3-Bis{[4-(l.l-dimethylethyl')phenyl1methyn-6-hydroxy-2,4-dioxo-1.213.44etrahydro-5- pynmidinyl)carbonyllglvcme 53a) N,N-Bis {[4-( 1,1 -dimethylethyl)phenyll methyl}urea. Diphosgene (725 µL, 6 0 mmoles) was added to a solution of 4-f-butylbenzylamme (880 uL, 5 Ommoles) in ethyl acetate (20 mL) under nitrogen atmosphere at room temperature A solid precipitated and the mixture was then heated to 70°C until the solid dissolved After stirring for 1 houi, 4-r-butylbenzylamme (880 uL, 5.0mmoles) was added and the mixture was stirred for 2 hours Dnsopropylethylamme (1 0 mL, 5.75 uL) was added and the mixture was stirred for 1 hour, washed with 1 molar hydrochlonc acid, dried and evaporated to an oil which solidified on standing overnight to give the title compound (710 mg, 40%) 1HNMR (400 MHz, DMSO-d6) δ ppm 7 30 - 7 38 (m 4 H), 7 17 (d, J=8 34 Hz, 4 H), 6 34 (t, J=5 94 Hz, 2 H), 4 18 (d, .J=5 S1 Hz, 4 H), 1 27 (s, 18 H) 53b) 1.3-Bis {[4-(l. 1 -dimethylethyl)pheny]]methyl} -2.4,b( 1H.3H,5fl)-pynmiduietnone. Malonyl dichloride (195 uL, 2.0 mmoles) was added to a stirred solution of AW-bis{[4-(l,l-dimethylethyl)phenyl]methyl}urea m dichloromethane (80 mL) and the mixture was heated under reflux for 2 hours. The mixture was washed with 1 molar hydrochlonc acid, and punfied by flash chromatography (0-30% ethyl acetate in hexane) to give the title compound (700 mg, 84%) 1H NMR (400 MHz, DMSO- 53c) N-f(1.3-Bis(r4-(Ll-dimethylethyl)phenyllmethyli-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidmyDcarbonyllglycine. A mixture of l,3-bis{[4-( 1,1 dimethylethyl)phenyl]methyl}-2,4,6(1H,3H,5H)-pynmidinetrione (700 mg, 1 66 mmoles) and diisopropylethylamme (574 uL, 3 32 mmoles) was stirred in dichloromethane (50 mL) and treated with ethyl isocyanatoacetate (202 uL, 1 8 mmoles) The mixture was stirred for 5 hours, then warmed to complete reaction. The mixture was washed with 1 molar hydrochlonc acid, evaporated, taken up m ethanol - 6 molar sodium hydroxide solution, stirred and gently warmed to complete hydrolysis The mixture was acidified and extracted into ethyl acetate The extracts were evaporated and a solid obtained from aqueous ethanol to give the title compound (700 mg, 81%). 1H NMR (400 MHz, DMSO-d6) δ ppm 9 67 (s, 1 H), 7 24 - 7 30 (m, 4 H), 7 16 (d, J=8 59 Hz, 4 H), 4.94 (s, 4 H), 3 42 (d, J=4 04 Hz, 2 H), 1 25 (s, 18 H) Example 54 (Formula Removed) N-{fl-Cyctohexyt-6-hydroxy-3-f4-methylCyclohexyl)-2.4-dioxo-l,2,3.4-tetriahydro-5- pynmidmvncarbonyl i glycine A solution of cyclohexyhsocyanate (1252 mg, 10 mmoles) in dichloromethane (20mL) was added dropwise to a solution of 4-methylcyclohexylamme (1132 mg, 10 mmoles) m dichloromethane (100 mL) The solution was allowed to stir at room temperature for 2 hours, then the solvent evaporated and the residue dissolved in dichloromethane (10 mL) along with malonyl chloride (10 mmol). The mixture was heated m a microwave synthesiser (80°C/20 mm) All volatiles were evaporated and the residue dissolved in of chloroform (10 mL) along with ethyl isocyanatoacetate (10 mmol), then the mixture was stirred at room temperature for 2 hours. Solvent was evaporated and the residue was purified by flash chromatography (ethyl acetate-hexane) to obtain the intermediate ester The ester was dissolved m a mixture of of ethanol (4 mL) and 1M aqueous NaOH (1 mL) The solution was stirred for 2 hours and neutralized by addition of 1M aqueous HC1 The solid was collected, washed with water (3X4 mL) and dried under vacuum overnight to give the title compound (443 mg, 11%) 1H NMR (400 MHz, CDC13) δ ppm 0 85 -0.96 (m, 2 H) 1.10 - 1 13 (m, 3 H) 1 16-1 50 (m, 6 H), 1 53 - 1 72 (m, b H) 1 73 - 1 89 (m, 3 H) 2.25 - 2.47 (m, 3 H) 2.50 - 2 66 (m, 1 H) 4 01 - 4 08 (m, 1 H) 4 23 (d, J=5 8 Hz, 1 H) 4 60 - 4 82 (m, 2H) 10 25- 10 36(m, 1 H) Example 5; (Formula Removed) N-({1-CyclohexyI-3-r4-(l.l-dimethylethyl)Cyclohexyn-6-hydroxy-2.4-dioxo-1.2,3.4-tctrahydro-5- pyrimidmyl} carbonyl)glvcme Using 4-fert-butylcyclohexylamme in place of 4-methylcyclohexylamme, the title compound was prepared in 21% yield (931 mg) following the procedures described m example 54 IH NMR (400 MHz, CDC13) δ ppm 0 77 - 0 94 (m, 13 H) 1 03 - 1 45 (m, 6 H)l 45 - 1 77 (m, 5 H) 1 77 - 1 97 (m, 3 H) 2 18 - 2.48 (m, 3 H) 4 01 - 4 10 (m, 1 H) 4 24 (d. J=5 6 Hz. 1 H) 4 58 - 4 82 (m,2H) 10.26-10 36 (m, 1 H) Example 56 (Formula Removed) N--[(l-Cyclohexyl-6-hydroxy-2.4-dioxo-3-phenyl-1,2.3,4-tetrahydro-5-pynmidinyDcarbonyllglvcme Using aniline in place of 4-methylcyclohexylamme, the title compound was prepared in 5% yield (198 mg) following the procedures described in example 54 IH NMR (400 MHz. CDCI3) δ ppm 1 02 - 1 46 (m, 5 H) 1 54 - 1 78 (m, 3 H) 1 78 - 1 98 (m, 2 H) 2 2d - 2 47 (m, 2 H) 4.21 (dd,J=5 8, 19 Hz, 2 H) 4 69 - 4 87 (m, 1 H) 7 Id - 7 31 (m, 2 H) 7 40 - 7 4d (m, 3 H) 10.06 -10.42 (m, 1 H) Example 57 (Formula Removed) N-( 11 -Cyclohexyl-3-r4-(l. l-dimethylethyl)phenyn-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5- pynmidinyl icarbonyQglycine Using 4-terZ-butylamline in place of 4-methylcyclohexylamme, the title compound was prepared m 7%yield (321 mg) following the procedures described in example 54 IH NMR (400 MHz, CDC13) δ ppm 1 09 - 1.24 (m, 1 H) 1 26 - 1 43 (m, 13 H) 1 58 - 1 77 (m, 3 H) 1 78 - 1 91 (m, 2 H) 2 27 - 2.49 (m, 2 H) 4 22 (dd, ^=14 7, 20 2 Hz, 2 H) 4 68 - 4 88 (m, 1 H) 7 16 (dd, J=8 6, 14 4 Hz, 2 H) 7.51 (dd, .J=14.4 Hz, 2 H) 10 10- 10 42(m, 1 H) Example 58 (Formula Removed) N- HI -CyclohexyI-3-fcyclohexylmethyl)-6-hydroxy-2.4-dioxo-1,2,3,4-terrahydro-5- pynmidinyl"|carbonyll glycine Using cyclohexylmethylamine in place of 4-methylcyclohexylamme, the title compound was prepared in 22% yield (442 mg) following the procedures descnbed in example 54 1H NMR (400 MHz, CDC13) δ ppm 0.85 - 1 11 (m, 2 H) 1 11 - 1 28 (m, 5 H) 1 28 - 1 48 (m, 2 H) 1 55 - 1 79 (m, 10 H) 1.79-1 91 (m, 2 H) 2 35 (dq,.J=3 0, 12 4 Hz, 2 H) 3 76 (d../M 4, 7 2 Hz, 2 H) 4 24 (dd, J=3.0, 7.2 Hz, 2 H) 4 65 - 4 83 (m, 1 H) 10 17 - 10 33(m, 1 H) Example 59 (Formula Removed) N-fr3-Cycloheptvl-l-cyclohexyl-6-hydroxy-2.4-dioxo-1.2.3.4-tetrahydro-5-pynmidinylkarbonyll glycine Using cycloheptylamine in place of 4-methylcyclohexylamme, the title compound was prepared in 29% yield (583 mg) following the procedures descnbed in example 54 IH NMR (400 MHz, DMSO-d«) 6 ppm 1 03 - 1 19 (m, 2 H) 1.19 - 1 34 (m. 3 H) 1 34 - 1 84 (m, 14 H) 2 14 - 2 36 (m, 4H)3.17(s,lH)4.06(d,J==5 6Hz, 2 H) 4 56 - 4 71(m, 1 H) 4 73 - 4 89 (m, 1 H) 10 11 -10.23 (m, 1 H) Example 60 (Formula Removed) N-r(3-Cyclohexyl-6-hydroxy-2.4-dioxo-l-tnCyclor3.3.1.13,7ldec-l -yl-1.2.3.4-tetrahydro-5- pynmidmyl )carbonyl] glycine Using 1-admantanamme hydrochloride in place of 4-methylcyclohexylamme, the title compound was prepared m 3% yield (66 mg) following the procedures described in example 54 1HNMR(400 MHz, CDC13) δppm 1.12 - 1 43 (m, 4 H) 1 54 - 1 88 (m, 12 H) 2 03 - 2 20 (m, 3 H) 2.23 - 2 28 (m, 2 H) 2 45 - 2 57 (m, 6 H) 4 21 (d, J-5 8 Hz, 2 H) 4 50 - 4 70 (m, 1 H) 10 16- 10 31 (m, 1 H) Example 61 (Formula Removed) N-({l-[lR.2RAS)-Bicyclo[2 2 11hept-2-yl]-3-Cydohexyl-6-hydroxy-2.4-dioxo-1,2.3.4-tetrahydro- 5-pynmidmvl) carbonyl )glycme Using exo-2-ammonoTbornane m place of 4-methylcyclohexylamme, the title compound was prepared in 30% yield (604 mg) following the procedures described in example 54 1H NMR (400 MHz, DMSO-dg) δ ppm 0 96 - I 34 (m, 9 H) 1 35 - 1 67 (m 6 H) 1 67 1 84 (m, 3 H) 2 20 -2.36 (m, 4 H) 4 01 (d, J=5 6 Hz, 2 H) 4 55 - 4 72 (m, 2 H) 10 11 - 10 20(m, 1 H) Example 62 (Formula Removed) N- {[1 -Cyclohexyl-6-hydroxy-3-(3-methylCyclohexyl)-2,4-dioxo-l ,2.3,4-tetrahydro-5 pynmidinyllearbonyl} glycine Using 3-methylcyclohexylamine m place of 4-methylcyclohexylamme, the title compound was prepared in 41% yield (836 mg) following the procedures described m example 54 1H NMR (400 MHz, DMSO-de) δ ppm 0 89 (d, J=b 6 Hz, 3 H) 0 97 - 1 48 (m, 8 H) 1 49 - 1 67 (m, 6 H) 1 69 - 1 86 (m, 3 H) 2.08 - 2 37 (m, 4 H) 4 06 (d, J=5 6 Hz, 2 H) 4.55-4 76 (m, 2H) 10 12- 10 26(m, 1H) Example 63 (Formula Removed) N-[(3-Cyclohexyl-1 -Cyclopropyl-6-hydroxy-2.4-dioxo-1,2,3,4-tetrahydro-5-pyniradinyl)carbonyllglycine Using cyclopropylamine in place of 4-methylcyclohexylamine, the title compound was prepared m 20% yield (351 mg) following the procedures described m example 54. IH NMR (400 MHz, CDC13) δppm 0 95 - 1 08 (m, 1 H), 1 12 - 1 28 (m, 4H), 1.29 - 1 42 (m, 1 H), 1 57 - 1 80 (m, 6 H), 1 80 - 1.89(m, 1 H), 2 28 - 2 42 (m, 2 H), 3 76 (d, J=l 1 H?, 2 H), 4 24 (dd, J=5 6, 3 5 Hz, 2 H), 4 66 - 4 82 (m, 1 H), 10 21- 10 31 (m, 1 H) Example 64 (Formula Removed) N-[(l-Cyclobutyl-3-cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5- pyrimidmyl)carbonyn glycine Using cyclobutylamme m place of 4-methylcyclohexy]amme, the title compound was prepared in 23% yield (424 mg) following the procedures described m example 54 IH NMR (400 MHz, CDCI3) Sppm 1 14-1.46 (m, 4 H) 1 56 - 1 98 (m, 7 H) 2 14 - 2 46 (m, 4 H) 2 80 - 3 00 (m, 2 H) 4 24 (d, J=5 6 Hz, 2 H) 4.58 - 4 83 (m, 1 H) 5 08 - 5 33 (m, 2 H) 10 22-10 32 (m, 1 H) Example 65 (Formula Removed) N-r(3-Cyclohexyl-l-Cyclopentyl-6-hydroxy-2.4-dioxo-1.2.3.4-tetrahydro-5-pyTimidinvOcarbonyl] glycine Method 1 65 1 Using cyclopentylamme m place of 4-methylcyclohexylamine, the title compound was prepared in 19% yield (357 mg) generally following the procedures described in example 54 1H NMR (400 MHz, CDC13) δ ppm 1 14 - 1.45 (m, 4 H) 1 52 - 1 73 (m, 5 H) 1 75 - 2 00 Cm, 7 H) 2 00 - 2.16 (m, 2 H) 2.24 - 2 43 (m, 2 H) 4.24 (dd, .J=1 3, 5 8 Hz, 2 H) 4 64 - 4 82 (m, 1 H) 5 11 - 5 38 (m, 1 H) 10 23- 10 35(m, 1 H) Method 2 65.2a) l-Cyclohexyl-3-Cyclopentyl-2.4.6(1H.3H.5H')-pynmidinetnone Cyclohexyl isocyanate (14.7 g, 117.34 mmoles) in dichloromethane (500 mL) under argon was treated with a solution of cyclopentylamine (11 58 mL, 117 34 mmoles) in dichloromethane (300 mL) and stirred overnight to leave a thick suspension of the urea. Malony] dichlonde (12 55 mL, 129 mmoles) in dichloromethane (200 mL) was added and the mixture was heated under gentle reflux for 3 5 hours The mixture was washed with 1 molar hydrochlonc acid (\2) dried and ev aporated Crystallization from ethanol and flash chromatography of the liquors (hexane to ethyl acetate) gave the title compound (18 9 g, 58%) 1H NMR (400 MHz, DMSO-d6) δ ppm 4 96 - 5.12 (m, 1 H), 4 46 (tt,J=12 13, 3 54 Hz, 1 H), 3 69 (s, 2 H), 2 15 (ddd, 2 H), 1 67 - 2.00 (m, 8 H), 1 41 - 1 66 (m, 5 H), 1 27 (m, 2 H), 1 11 (m, 1 H) pyrimidinyl)carbonyl]glvcine Ethyl isocyanatoacetate (8 33 mL,74.3 mmoles) was added to a mixture of l-cyclohexyl-3-cyclopentyl-2,4,6(1H,3/f,5H)-pynmidmetnone (18 8 g, 67.54 mmoles) and dnsopropylethylamine (23.53 mL, 135 08 mmoles) in dichloromethane (800 mL) and stirred for 2 hours. Reaction mixture from a prior run (approx 25% scale) was added The combined reaction mixture was washed with 2 molar hydrochlonc acid (2 x 1 0 L) and evaporated The residue was dissolved in ethanol (200 mL) and treated with 3.0 molar sodium hydroxide (100 mL) The mixture was stirred for 2 hours. Ethyl acetate (500 mL) was added and the mixture acidified with 6 molar hydrochlonc acid (200 mL), water (500 ml ) was added and the layers separated The aqueous layer was extracted with ethyl acetate (500 mL) and the organic solution was washed with 1 molar hydrochlonc acid. The organic solution was dned and evaporated to a solid residue which recrystallized from acetic acid (300 mL) to afford the title compound (15 5 g, 49%) Mp 222-224°C 1H NMR (400 MHz, DMSO-c/6) δ ppm 13 08 (s, 1 H), 10 17 (t, J=5 43 Hz, 1 H), 5 08 -5 33 (m, 1 H), 4 63 (t, J-12 25 Hz, 1 H), 4 12 (d, J=5 81 Hz, 2 H), 2 18 - 2 36 (m, 2 H), 1 93 - 2 06 (m, 2H), 1 69 - 1.91 (m, 6 H), 1 46 - 1 68 (m, 5 H), 1 28 (q J=12 88 Hz. 2 H), 1 12 (q, J-13 05 Hz, 1 H) Example 66 (Formula Removed) N- (f6-Hvdroxy-l .3-bis(3-methylbutvl)-2.4-dioxo-1.2.3.4-tetrahydro-5-pynmidinyllcarbonyl! glycine 66a) JVN-Qis(3-methylbutvl)urea Isoamylamme (1 4 mL, 12 mmoles) was added to a solution of [l,3]oxathiolo[4,5-6]pyridin-2-one (765 mg, 5 0 mmoles) m ethyl acetate (15 mL). The mixture was stirred for 2 hours, the solid collected, washed with ethyl acetate and dried to give the title compound (1 lg, 91%) 1H NMR (400 MHz, CHLOROFORM-rf) δ ppm 4 86 (br s, 2 H), 3.20 (td, J=7 33, 5.81 Hz, 4 H), 1.61-1 72 (m, J=13 39, 6 69, 6 69, 6 69, 6 69 Hz, 2 H), 1 40 - 1 48 (m, 4 H), 0 93 (d, J=6 57 Hz, 12 H). 66b) ,3-Bis(3-inethylbutvl)-2,4,6(1H,3^,5H)-pyrimidmetrione Ethyl malonyl chlonde (768 uL, 6 0 mmoles) was added to a solution of Ar,A/,-bis(3-methylburyl)urea (J 1 g, 5 5 mmoles) in chloroform (70 mL) and the mixture was stirred at 70°C for 2 hours The mixture was washed with 1 molar hydrochloric acid, dried and evaporated to give ethyl 3-((3-mcthylbutyl){[(3-methylbutyl)amino]carbonyl}amino)-3-oxopropanoate The intermediate was dissolved m ethanol (30 mL), DBU (900 uL, 6 mmoles) and heated to 70°C for 5 minutes. The mixture was cooled, diluted with ethyl acetate and washed with 1 molar hydrochloric acid, dried and evaporated to give the title compound (1.2 g, 81%). 1H NMR (400 MHz, DMSO-^e) δ ppm 3.65 - 3 78 (m, 3 H), 1.56 (dt, J=20.02, 13.33, 6 57 Hz, 1 H), 1 32 - 1 44 (m, 2 H), 0 90 (d,J=6 57 Hz, 6 H) 66c) -{[6-Hvdroxy-1.3-bis(3-methylbutvl)-2.4-dioxo-1.2.3.4-tetrahydro-5-pyrimidinyllcarbonyl{glycine A mixture of 1,3-bis(3-methylbutyl)-2,4,6( IH,3H,5H)~ pyrimidinetrione (1.2 g, 4 47 mmoles) and dnsopropylethylamme (1 56 mL, 8 94 mmoles) was stirred m dichloromethane (30 mL) and treated with ethyl isocyanatoacetate (501 uL, 4 47 mmoles) The mixture was stirred for 5 hours, washed with 1 molai hydrochloric acid (x2), evaporated, taken up in ethanol - 6 molar sodium hydroxide and stirred overnight The mixture was acidified and extracted into ethyl acetate (x2) The extracts were washed with 1 molar hydrochloric acid evaporated, dried and evaporated The title compound was recrystalhzed from acetic acid (430 mg, 26%). 1H NMR (400 MHz, DMSO-d6) δ ppm 13 09 (br s, 1 H), 10 11 (s, 1 H), 4 09 - 4 16 (m, 2 H), 3.77 - 3.86 (m, 4 H), 1 51 - 1 62 (dt, .J=13 29, 6 59, 6 59. 6.59, 6 59 Hz, 2 H), 1 42(q,J=7.07Hz,4H), 0.91 (d,J=6 57Hz, 12H) Example 67 (Formula Removed) N-r(6-Hvdroxy-1,3-bis (r2-(methyloxy)phenyl1methyl! -2.4-dioxo-1,2,3,4-tetrahydro-5- pynmidinvDcarbonvil glycine 67a) 1.3-Bis{[2-rmethyloxy)phenyl1methyl}-2.4,6(li/,3H,5H)-pynmidinetnone 2-Methoxybenzyl isocyanate (923 uL, 6 0 mmoles) was added to a solution of 2-methoxybenzylamine (775 uL, 6 0 mmoles) in chloroform (100 mL) and the mixture stirred for 1 hour. Ethyl malonyl chloride (768 uL, 6 0 mmoles) was added and the mixture was heated to 70°C for 2 hours. DBU (1.0 mL) was added and the mixture was heated for a further 1 hour The mixture was cooled and washed with 1 molar hydrochloric acid (x2), dried and evaporated The title compound was obtained as a solid by trituration in diethyl ether (1.65 g, 75 IB NMR (400 MHz, DMSO- 67b) N-[(6-hydroxy-1.3-bis {r2-(methyloxy)phenyl1methyl} -2.4-dioxo-1.2.3.4-tetrahydro-5-pyrimidinyl)carbonynglyeine. A mixture of 1,3-bis {[2-(methyloxy)phenyl]methyl} -2,4,6(1H,3H,5H)-pyrimidinetrione (1.64 g, 4 45 mmoles) and dnsopropyiethylarnme (1 56 mL, 8.94 mmoles) was stirred in dichloromethane (30 mL) and treated with ethyl isocyanatoacetate (500 uL, 4 45 mmoles). The mixture was stirred for 5 hours, washed with 1 molar hydrochloric acid (x2), evaporated, taken up in ethanol - 6 molar sodium hydroxide and stirred overnight. The mixture was acidified and extracted into ethyl acetate (x2) The extracts were washed with 1 molar hydrochloric acid evaporated, dried and evaporated The title compound was recrystallized from acetic acid(l 0g,48%). 1H NMR (400 MHz, DMSO-J6) δ ppm 1251 (br.s., 1 H), 10.11 (t, J=4.93 Hz, 1 H), 7 20 - 7.28 (m, 2 H), 7 00 (d. J=7 83 Hz, 2 H), 6 86 - 6 96 (m, 4 H), 5.00 (s, 4 H), 4.10-4 18(m,2H), 3 82 (s, 6 H) Example 68 (Formula Removed) N-( (1,3-Bisrri-chlorophenynmethyll]-hydroxy-2,4-dioxo-l ,2.3,4-tetrahydro-5- pyrimidinv 1) carbonyl) glycine 68a) 1.3-BisrC2-chIorophenyl)methyl]-2.4.6(1H.3H,5H)-pyTimidinetnone 2-Chlorobenzyl isocyanate (875 uL, 6.0 mmoles) was added to a solution of 2-chlorobenzylamme (725 uL, 6 0 mmoles) in chloroform (100 mL) and the mixture stirred for 1 hour Ethyl malonyl chloride (768 uL, 6.0 mmoles) was added and the mixture was heated to 70°C for 2 hours DBU (1 0 mL) was added and the mixture was heated for a further 1 hour The mixture was cooled and washed with 1 molar hydrochloric acid (x2), dned and evaporated to an oil (2.0 g, 88%) 1HNMR (400 MHz, DMSO-d6) δ ppm 7.45 - 7 49 (m, 2 H), 7 40 - 7 45 (m, 2 H), 7 28 - 7 32 (in, 4 H), 4 98 (s, 4 H), 4.02 (s, 2 H) 68b) N-( n.3-Bisrf2-chlorophenyl)methyn-6-hydroxy-2.4-dioxo-l .2.3.4-tetrahydro-5-pyrimidinvUcarbonvDglvcine. A mixture of l,3-bis[(2-chlorophenyl)methyl]-2,4,6( \H,3H,5H)-pyrimidmetnone (2.0 g, 5.3 mmoles) and dusopropylethylamine (1 85 mL, 10 6 mmoles) was stirred in dichloromethane (35 mL) and treated with ethyl isocyanatoacetate (594 uL, 5 3 mmoles) The mixture was stirred for 5 hours, washed with 1 molar hydrochloric acid (x2). evaporated, taken up in ethanol - 6 molar sodium hydroxide and stirred overnight The mixture was acidified and extracted into ethyl acetate (x2). The extracts were washed with 1 molar hydrochloric acid evaporated, dried and evaporated The title compound was recrystalhzed from acetic acid (1 59 g, 62%) 1H NMR (400 MHz, DMSO-J6) δ ppm 13 06 (br s., 1 H), 10 13 (s, 1 H), 7 41 - 7 60 (m, 2 H), 7 30 (dd, J=5 81, 3 28 Hz, 4 H), 7 21 (dd, .J=5 31. 3 79 Hz. 2 H), 5 09 (s, 4 H), 4 15 (s, 2 H) Example 69 (Formula Removed) N-[( 1.3-Dihexyl-6-hydroxy-2.4-dioxo-1.2.3.4-tetrahydro-5-pynmidmvl)caTbopyl'|glvcme Hexyl isocyanate (728 uL, 5 0 mmoles) was added to a solution of «-hexylamme (660 uL, 5.0 mmoles) in dichloromethane (100 mL) and the mixture stirred for 1 hour. Malonyl dichlonde (486 uL, 5 0 mmoles) was added and the mixture was heated to gentle reflux for 1 hour The mixture was washed with 1 molar hydrochloric acid (x2), dried and evaporated The residue was redissolved in dichloromethane (50 mL) and diisopropylethylamme (1 73 mL, 10 mmoles) and the mixture was treated with ethyl isocyanatoacetate (561 uL, 5 0 mmoles) After stirring overnight the mixture was washed with 1 molar hydrochloric acid, dried and evaporated The residue was dissolved m ethanol (5 mL) and treated with 6 molar sodium hydroxide (2 0 mL) The mixture was stirred for 1 hour, acidified and extracted into ethyl acetate The organic solution was washed with 1 molar hydrochlonc acid, dried and evaporated The crude product was slurried m hexane to afford the title compound (890 mg, 45%) 1HNMR (400 MHz, DMSO- Example 70 (Formula Removed) N- {[1 -Cyciohexyl-6-hydroxy-3-(2-methylcyclohexyl)-2.4-dioxo-1.2,3,4-tetrahydro-5- pynmidmyllcarbonvU glycine Using 2-methylcyclohexylamine in place of 4-methylcyclohexylamme, the title compound was prepared in 19% yield (390 mg) following the procedures described m example 54 1H NMR (400 MHz, CDC13) δ ppm 0 68 - 0 84 (m, 3 H) 1 14 - 1 43 (m, 8H) 1 5 3 1.76 (m, 5 H) 1 76 - 1 90 (m, 4H) 2 14 - 2.43 (m, 3 H) 4 18 - 4 27 (m, 2 H) 4 38 - 4 54 (m, 1 Hj 4 62 - 4 87 (m, 2 H) 10.21 10 43 (m, 1 H) Example 71 (Formula Removed) N-{ri-Cyclohexyl-6-hydroxy-3-(2-naphthalenyl)-2,4-dioxu-K2,3.4-tetrahydro-5- pynmidinyllcarbonyl f glycine Using 2-aminonaphthalene in place of 4-methylcyclohexylamme, the title compound was prepared m 0 6% yield (12 9 mg) following the procedures described in example 54. 1H NMR (400 MHz, CDC13) δ ppm 1.04 - 1.19 (m, 1 H) 1 27 - 1 46 (m, 2 H) 1 57 - 1 93 (m, 6 H) 2 26 - 2 48 (m, 2 H) 4 06-4.21 (m, 1 H) 4 23 (d, J=5 6 Hz, 1 H)4 72-4 91(m, 1 H)7 39(dd,J=l 0, 7 3 Hz, 1 H) 7 47 - 7 65 (m, 4 H) 7 84 - 8 03 (m, 2 H) 10 21 (t, J=5 6 Hz, 1 H) Example 72 (Formula Removed) N-r(l-Cyclohexyl-3-hexyl-6-hydroxy-2.4-dioxo-1.2,3.4-tetrahydro-5-p'VTimidmvl)carbonynglvcme Cyclohexyl isocyanate (635 uL, 5 0 mmoles) was added 10 a solution of M-hexylamme (660 uL, 5.0 mmoles) m dichloromethane (100 mL) and the mixture stirred for 1 hour Malonyl dichloride (486 uL, 5.0 mmoles) was added and the mixture was heated to gentle reflux for 1 hour The mixture was washed with 3 molar hydrochloric acid (x2), dried and evaporated The residue was redissolved in dichloromethane (50 mL) and diisopropylethylamme (1.73 mL. 10 mmoles) and the mixture was treated with ethyl isocyanatoacetate (561 uL, 5 0 mmoles) After stirring overnight the mixture was washed with 1 molar hydrochloric acid, dried and evaporated. The residue was dissolved in ethanol (5 mL) and treated with 6 molar sodium hydroxide (2 0 mL) The mixture was stirred for 1 hour, acidified and extracted into ethyl acetate The organic solution was washed with 1 molar hydrochloric acid, dried and evaporated to a brown oil. The crude material was stood in a freezer overnight in hexane to afford some solid The liquors were concentrated and purified by preparative HPLC (acetonitrile-water-0.1 % TFA) to give additional material which was combined with the previously obtained solid and recrystallized from ethanol-water to give the title compound (480 mg, 24%). IH NMR (400 MHz, DMSO- (Formula Removed) N-[(l ,3-Dicycloheptyl-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pynmidmyl)carbonyl]glycine Using cycloheptylarmne in place of 4-methylcyclohcxylamme and cycloheptyhsocyanate m place of cyclohexyhsocyanate, the title compound was prepared m 7% yield (142 6 mg) following the procedures described in example 54 IH NMR (400 MHz, CDCh) δ ppm 1 19 - 1 36 (m, 2 H) 1 37 - 1.92 (m, 17 H) 2 20 - 2 42 (m. 6 H) 4 15 (d, .J=5.8 Hz. 2 H) 4 69 - 5 03 (m. 3 H) 10.20 - 10 46 (m, I H) Example 74 (Formula Removed) N-[(l,3-Dicyclopentyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pynmidmyl)carbonyl]glycine Method 1 Using cyclopentylamine in place of 4-methylcyclohexytamme and cyclopentyhsocyanate m place of cyclohexyhsocyanate, the title compound was prepared in ] 4% yield (263 mg) following the procedures described in example 54 IH NMR (400 MHz, CDCH) S ppm 1 50 - 1 66 (m, 4 H) 1.75 - 1.88 (m, 4 H) 1.88 - 2.00 (m, 4 H) 2 01 - 2 16 (m, 4 H) 2 56 - 2 71 (m, 1 H) 3 06 3.27 (m, 1 H)4 14 (d, J=5.6 Hz, 2H) 5 12-5 40 (m, 2 H) 10 28- 10 41 (Formula Removed) N-{[l-Cyclohexyl-3-(2,3-dimethylcyclohexyl)-6-hydro\y-2,4-dioxo-l,2,3,4-terrahydro-5- pynmidinyl]carbonyl } glycine Using 2,3-dimethylcyclohexylamrne in place of 4-methylcyclohexylamme, the title compound was prepared in 5% yield (85 mg) following the procedures descnbed in example 54 LC/MSm/z422(M+Hf) Example 76 (Formula Removed) 4-[5-{[(Carboxymethyl)amino]carbonyl]-3-cyclohexyl-4-hydroxy-2,6-dioxo-3,6-dihydro-l(2H)- pyrimidmyljcyclohexanecarboxyhe acid Using 4-ammocyclohexanecarboxylic acid in place of 4-methylcyclohexylamine, the title compound was prepared in 16% yield (151 mg) following the procedures descnbed in example 54 LC/MS m/z 438 (M+H+) Example 77 (Formula Removed) N-{[l-Cyclohexyl-3-(4-ethylcyclohexyl)-6-hydroKy-2,4-dioxo-1,2.3,4-tetrahydro-5- pynmidmyl]carbonyl} glycine Using 4-ethylcyclohexylamme m place of 4-methylcyclohexylamme, the title compound was prepared in 20% yield (185 mg) following the procedures described in example 54 IH NMR (400 MHz, CDC13) δ ppm 0.85 - 0 96 (m, 3 H) 1 10 - 1 40 (m, 8 H) 1 53 - 1 72 (m, 6 H) 1 73 - 1 89 (m, 3 H) 2 19 - 2.61 (m, 3 H) 3.85 - 4 04 (m, 1 H) 4 09 - 4 34 (m, 1 H) 4 59 - 4 85 (m, 2 H) 5 07 -5 32 (m, 2 H) 10.30 - 10.426 (m, 1 H) Example 7X (Formula Removed) as-4-[3-Cyclohexyl-5-({[2-(ethyloxy)-2-oxoethyl]ammo}carbonyl)-4-hydroxy-2,6-dioxo-3,6-dihydro-l(2/f)-pynmidmyl]cycIohexanecarboxyhc acid Using «,y-4-ammocyclohexanecarboxylic acidl in place of 4-methylcyclohexylamine, the title compound was prepared in 9% yield (114 mg) following the procedures described in example 54 LC/MS m/z 466 (M+H+) Example 79 (Formula Removed) N- {[1 -Cyclohexyl-6-hydroxy-3-( 1 -methylcyclohexyl)-2,4-dioxo-1,2.3,4-terrahydro-5- pynmidinyljcarbonylj glycine Using 1-ammo-l-methylcyclohexane in place of 4-methylcyclohexylamine, the title compound was prepared in 18% yield (595 mg) following the procedures described in example 54 lHNMR(400MHz, CDC13) δ ppm 0 97 - 1 18 (m, 3 H) 1 19 - 1 44 (m, 9 H) 1 46 - 1 74 (m, 5 H) 1 77 - 1 99 (m, 4 H) 2 22 -2.40 (m, 2 H) 3 11 - 3 30 (m, 2 H) 4 07 - 4 37 (m, 2 H) 4 50 - 4 78 (m, 1 H) 10 15- 10 35(m, 1 H) Example 80 (Formula Removed) 3-r5-{r(Carboxymethyl)aminolcarbonyll-3-Cyclohexyl-4-hydroxy-2,6-dioxo-3,6-dihydro-U2H)- pyrimidinyllcyclohexanecarboxyhc acid Using 3-ammocyclohexanecarboxyhc acid m place of 4-methylcyclohexylamme, the title compound was prepared in 18% yield (184 mg) following the procedures descnbed in example 54 LC/MS m/z 438 (M+tT) Example 8 I (Formula Removed) N-{[l-Cyclohexyl-6-hydroxy-2,4-dioxo-3-(2-oxo-2-phenylethyl)-l,2,3,4-tetrahydro-5- pynmidiny Ijcarbonyl J glycine A mixture of ethyl N-[(3-cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pynmidinyl)carbonyl]glycinate (300 mg, 0 88 mmoles), 2-bromoacetophenone (350 mg, 1 76 mmoles) and potassium carbonate (243 mg, 1 76 mmoles) m DMF (4 mL) was heated m a microwave synthesiser at 100°C for 15 minutes, then cooled and filtered The residue was washed with dichloromethane (3X3 mL) and the combined filtrate was evaporated and purified by flash chromatography (ethyl acetate-hexane) to obtain the desired crude ester The ester was dissolved in ethanol (3 mL) and 1M aqueous NaOH {1 mL) and the solution stirred for 2 hours, then neutralized by addition of 1M aqueous HCL The solid was collected, washed with water (3X4 mL) and dried under vacuum overnight to give the title compound (51 mg, 20%) 1H NMR (400 MHz, CDC13) δ ppm 1.10- 1 27 (m, 1 H) 1 27 - 1 45 (m, 2 HU 58 - 1 77 (m, 3 H> 1.77 - 1.95 (m, 2 H) 2.24 - 2 43 (m, 2 H) 3 56 - 5 09 (brs. 2 H), 4 19 - 4.26 (m, 2 H) 4.62 • 4 85 (m, 1 H) 5.31 -5.41 (m, 2 H) 7.45 - 7.55 (m, 2 H) 7 58 - 7 66 (in, I H) 7 97 - 8.03 (m, 2 H) 10 04 - 10 42 (Formula Removed) N-[( 1 -Cyclohcxyl-6-hydroxy-3- ;244-(methyloxy)phenyl]-2-oxoethv 1} -2,4-dioxo-1,2,3,4-tctrahvdro-5-pyrimidinyl)carbonvllglvcine Using 2-bromo-4'-methoxyacetophenonc in place of 2-bromoacetophenene, the title compound was prepared m 48% yield (196 mg) following the procedures described in example 81 LC/MS m/z 460 (M+H+) Example 83 (Formula Removed) N-({ 1 -Cyclohexyl-6-hydroxy-3-[2-(4-methylphenyl)-2-oxoethyl]-2,4- Example 84 (Formula Removed) N-{[l-Cyclohexyl-3-(3,3-dimethyl-2-oxobutyl)-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro--5- pynrmdmyljcarbonylj glycine Using 1 -bromopmacolone m place of 2-bromoacctophenone, the title compound was prepared m 31% yield (114 mg) following the procedures described m example 81 1H NMR (400 MHz, CDC13) δppm 1 01 - 1 45 (m, 5 H) 1 26 (s, 9 H) I 57 - 1.76 (m, 3 Hi 1 76 - 1 91 (m, 2 H) 2 22 - 2 43 (m, 2 H) 4.15 - 4 30 (m, 2 H) 4 62 - 4 79 (m, 1 H) 4 82 - 4 97 (m, 2 H) 9 97 - 10 39 (m, 1H) Example 85 (Formula Removed) 7Y-({l-Cyclohexyl-3-[2-(4-fluorophenyl)-2-oxoethyl]-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5- pynmidinyl} carbonyl)glycme Using 2-bromo-4'-fluoroacetophenone in place of 2-bromoacetophenone, the title compound was prepared in 69% yield (275 mg) following the procedures described in example 81 lHNMR(400MHz,CDCl3)8ppml.06- 1 43 (m, 5 H) 1 55 - 1 76(m, 3 H) 1 76- 1 93 (m, 2 H) 2.23 - 2 43 (m, 2 H) 4.09 - 4.33 (m, 2 H) 4 65 - 4 84 (m, 1 H) 5 28 - 5 38 (m, 2 H) 7 13 - 7 23 (m, 2 H) 7 99-8 08 (m, 2H) 10.01 - 10.52 (m, 1 H) Example 86 (Formula Removed) N-({3-[2-(4-Cyanophenyl)-2-oxoethyl]-l-cyclohex>l-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5- pynmidinyl}carbonyljglycme Using 2-bromo-4'-cyanoacetophenone m place of 2-bromoacetophenone, the title compound was prepared in 65% yield (259 mg) following the procedures descnbed in example 81 1H NMR (400 MHz, CDCl3) δ ppm 1 05 - 1 45 (m, 5 H) 1 59 - 1 77 (m, 3 H) 1 77 - 1.91 (m, 2 H) 2.21 - 2 40 (m, 2 H) 4 18 - 4.29 (m, 2 H) 4 64 - 4.83 (m, 1 H) 5 29 5 41 (m, 2 H) 7 79 - 7 85 (m, 2 H) δ.09 (d, .J=8.6 Hz, 2 H) 9.99 - 10 45 (m, 1 H) Example 87 (Formula Removed) N-({3-r2-(l-Benzofiiran-2-vlV2-oxoethyll-l-Cyclohexyl-6-hydroxy-2.4-dioxo-1.2.3.4-tetrahydro-5- pynmidinyl}carbonyl (glycine Using l-(l~benzofuran-2-yl)-2-brornoethan-l-one m place of 2-bromoacetophenone, the title compound was prepared in 44% yield (183 mg) following the procedures descnbed in example 81 1HNMR (400 MHz, CDCh) δ ppm 1 04 - 1 44 (m, 5 H) 1 59 - 1 77 (m, 3 H) 1 H -1.91 (m, 2 H) 2.25 - 2 43 (m, 2 H) 4 16 - 4 28 (m, 2 H) 4 65 - 4 84 (m, 1 H) 5 30 - 5 40 (m, 1 H) 7.30 - 7 38 (m, 1 H) 7 46 - 7 56 (m, 1 H) 7 56 - 7.67 (m, 2 H) 7 69 - 7 78 (m, 1 H) 10.02 - 10 45 (m, 1 H) Example 88 (Formula Removed) N- {[3-Cyelohexyl-6-hydroxy-1 -(1 -naphthalenyl )-2.4-dioxo-1.2.3,4-tetrahydro-5- pynmidinyl Icarbonyl \ glycine Using 1-armnonaphthalene in place of 4-methylcyelohexylamme, the title compound was prepared in 20% yield (257 mg) following the procedures described in example 54. IH NMR (400 MHz, CDC13) δ ppm 1 07 - 1.43 (m, 4 H) 1 56 - 1 90 (m, 5 H) 2 27 - 2 48 (m, 2 H) 4 05 - 4.19 (m, 2 H) 4 23 (d, J=5.8 Hz, 1 H) 4.71 - 4 92 (m. 1 H) 7 37 - 7 4b (m, 1 H) 7 48 - 7 61 (m. 4H) 7 87 -8.00 (m, 2 H) 9.99 - 10 46 (m. 1 H) Example 89 (Formula Removed) N- {[3-Cyclohexyl- l-(4.4-dimethylCyclohexyl)-6-hydroxy-2.4-dioxo-1,2.3.4-tetrahydro-5- pynmidinyl]carbonyl} glycine Usmg 4,4-dimethylcyclohexylamme in place of 4-methylcyclohexylamme, the title compound was prepared in 3% yield (45 mg) following the procedures described in example 54. lHNMR(400MHz,CDCl3)δppm0.93(s, 3 H) 1.02(s, 3 H) 1 14 - 1 53 (m, 11 HH 56 - 1.72 (m, 3 H) 1 77 - 1.89 (m, 2 H) 2.26 - 2.43 (m, 2 H) 2 45 - 2 05 (m. 2 H) 4 15 - 4 32 (m, 2 H) 4 57 4.84 (m, 2 H) 10.20 - 10.40 (m, 1 H) Example 90 (Formula Removed) N-({1-Cycloheayl-3-f(2.3-difluorophenyl)methyn-6-hydroxy-2.4-dioxo-1.2.3.4-tetrahydro-5-pyrimidinyl} carbonvDglvcme A mixture of ethyl AL[(l-cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycinate (340 mg, 1.0 mmoles), pulv potassium carbonate (750 mg, 5 35 mmoles) and 2,3-difluorobenzyl bromide (255 uL, 2 0 mmoles) in dimethylacetamide (5 mL) was vigorously stirred at 100°C for 3 hours The mixture was poured into 1 molar hydrochloric acid and extracted with ethyl acetate (x2) The combined organic solutions were washed with 1 molar hydrochloric acid and evaporated. The residue was purified by flash chromatography (10-50% ethyl acetate in hexane), the required fractions evaporated, dissolved m ethanol (5 mL) and 1 molar sodium hydroxide solution (3 0 mL) added The mixture was stirred overnight, acidified and extracted with ethyl acetate (x2), the combined extracts washed with 1 molar hydrochloric acid, dried and evaporated. Recrystalhzation from ethanol-water gave the title compound (140 mg, 32%) IH NMR (400 MHz, DMSO-d6) δ ppm 13 10 (br s . 1 H), 10 11 (br s , 1 H), 7 25 - 7.43 (m, 1 H), 7 08 - 7 23 (m, 1 H), 7.03 (t, J=l 07 Hz, 1 H), 5 08 (s, 2 H), 4 55 - 4 73 (m, 1 H), 4 13 (d, .J=5.81 Hz, 2 H), 2.12 - 2.35 (m, 2 H), 1 78 (d. J=12.63 Hz, 2 H), 1 63 (s, 3 H), 1 20 - 1 38 (m, 2 H), 1.02- 1 18 (m, 1 H) Example 91 (Formula Removed) Ethyl N-f(1.3-diCyclohexyl-6-hydroxy-2,4-dioxo-1.2,3,4-tetrahydro-5-pynmidmyl)carbonothioyl]glycinate A mixture of l,3-dicyclohexyl-2,4,6(l/7,3H,5H)-pyrimidmetnonc (660 mg, 2 25 mmoles), dusopropylethylamine (780 uL, 4 5 mmoles) and ethyl isocyanatoacetate (340 uL, 2 75 mmoles) in chloroform (20 mL) was stirred for 6 hours The mixture was washed with 1 molar hydrochloric acid (x2), dried and evaporated The solid residue was purified by flash chromatography (0-20% ethyl acetate in hexane) and crystallization from ethanol to give the title compound (250 mg, 25%) IH NMR (400 MHz, DMSO-d6) δ ppm 12.57 (t, .J=5 18 Hz, 1 H). 4 69 (t, 2 H), 4 44 (d, J=5 31 Hz, 2H),4 17(q,J=724Hz, 2 H), 2 25 (q, 4 H), 1 79 (d, J=12.88 Hz, 4 H), 1 55 - 1.72 (m,6H), 1 24 - 1.38 (m, 4 H), 1 22 (t, J=7 07 Hz, 3 H), 1 12 (q,.J=12.88 Hz, 2 H) Example 92 (Formula Removed) N-[(1,3-Dicyclohexyl-6-hydroxy-2.4-dioxo-1.2.3.4-tetrahydro-5-pyrimidinyl)carbonothiovl] glycine A mixture of l,3-dicyclohexyl-2,4,6(1H,3H,5i/)-pynmidinernone (660 mg, 2.25 mmoles), diisopropylethylamine (780 uL, 4 5 mmolesj and ethyl isothiocyanatoacetate (340 uL, 2.75 mmoles) in chloroform (20 mL) was stirred overnight The mixture was washed with 1 molar hydrochloric acid (x2), dried and evaporated The solid lesidue was purified by flash chromatography (dichloromethane) and the fractions evaporated, dissolved in cthanol (5 mL, some heating) and treated with 1 molar sodium hydroxide (3 mL) The mixture was stirred for 30 minutes and acidified to give a solid which reerystalhzed from ethanol-water to give the title compound(135 mg, 15%) 1H NMR(400 MHz, DMSO-d6) δppm 13 I6U, 1 H), 12 54 (t, J=4 80 Hz, 1 H), 4 69 (t, J=12 00 Hz, 2 H), 4 35 (d, 7-5 05 Hz, 2 H), 2 25 (q, 4 H), 1 79 (d, J=12 38 Hz, 4 H), 1 63 (d, .J=12 38 Hz, 6 H), 1 29 (q, 4 H), 1 13 (q,2H) Example 93 (Formula Removed) 6-f5-{rrCarboxymethyl')amino1carbonyl}-3-Cyclohexyl-6-hydroxy-2,4-dioxo-3,4-dihydro-l(2H)- pynmidinyl]hexanoic acid 93a) Ethyl 6-f3-Cyclohexyl-2.4.6-tnoxotetrahydro-1 (2H)-pynmidmyl)hexanoNe. Ethyl isocyanatohexanoate (790 mg, 4 26 mmoles) and cyclohexylamine (490 uL, 4 26 mmoles) were stirred together m dichloromethane (100 mL) for 2 hours Malonyl dichlonde (414 uL, 4 26 mmoles) was added and the mixture was heated under gentle reflux for 2 hours The mixture was purified by flash chromatography (dichloromethane to 5% methanol in dichloromethane) to give the title compound (1.07 g, 71%) 1H NMR (400 MHz, CHLOROFORMd) δ ppm 4 56 - 4 67 (m, 1 H), 4.62 (tt, J=12.25, 3 79 Hz, 1 H), 4 13 (q, J=7 24 Hz, 2 H), 3 85 (t, 2 H), 2.31 (t, 2 H), 2.26 (dq, 2 H), 1.85 (d,J=13 39 Hz, 2 H), 1 57 - 1 73 (m, 7 H), 1 29 - 1 43 (m, 4 H), 1 26 (t, J=7 07 Hz, 3H), 1.06- 1.24 (m, 2 H) 93b) 6-[5-{[(Carboxymethyl)amminolcarbonyl} -3-Cyclohexyl-6-hydroxy-2.4-dioxo-3.4-dihydro- 1 (2ffi-pyriroidinyl1hexanoic acid. A mixture of ethyl 6-(3-cyclohexyl-2.4,6-tnoxotetrahydro-l(2H)- pyrimidinyl)hexanoate (330 mg, 0.936 mmoles) and diisopropylethylamme (324 uL, 1 87 mmoles) in chloroform (30mL) was treated with ethyl isocyanatoacetate (126 uL. 1.12 mmoles) and stirred overnight. The mixture was washed with 1 molar hydrochloric acid (\2), dried and evaporated The residue was taken up in ethanol and treated with 1 molar sodium hydroxide (2 mL) and stirred for 1 hour. The mixture was acidified and extracted into ethyl acetate The organic solution was washed with 1 molar hydrochloric acid, dried and evaporated. Crystallization from acetic acid afforded the title compound (160 mg, 40%) 1H NMR (400 MHz, DMSO-d6)δ ppm 13 06 (br s , 1 H), 12 08 (bi s.. 1 H), 10.15 (t,J=5.81 Hz, 1 H), 4 63 (t, J=9 22 Hz, 1 H), 4 12 (d,J=5 81 Hz, 2 H), 3.66 - 3.87 (m, 2 H), 2 26 (d, J=l 1.37 Hz, 2 H), 2 20 (t, J=7 33 Hz, 2 H), 1 79 (d, .J=12.88 Hz, 2 H), 1 57 - 1.68 (m, 3 H), 1 46 - 1.57 (m, 4 H), 1 21 - 1 35 (m, 4 H), I 04 - 1 19 (m, 1 H) Example 94 (Formula Removed) 6-[5-{[('Carboxymethyl)aminolcarbonothiovll-3-Cyclohexyl-6-hydroxy-2.4-dioxo-3T4-dihydro- l(2/f)-pyrimidmyl]hexanoic acid A mixture of ethyl 6-(3-cyclohexyl-2,4,6-tnoxotetrahydro-l(2i/)-pynm]diByl)hexanoate (330 mg, 0.94 mmoles), diisopropylethylamme (324 uL, 1 87 mmoles) and ethyl isothiocyanatoacetate (139 uL, 1.12 mmoles) in chloroform (20 mL) was stirred for 7 days. The mixture was washed with 1 molar hydrochloric acid (x2), dried and evaporated The residue was purified by flash chromatography (hexane - 20% ethyl acetate in hexane) to give the title compound as a clear oil (250 mg, 60%). The diester was dissolved m ethanol (3 mL) and treated with 1 molar sodium hydroxide (2 mL) The mixture was stirred overnight, taken up in eth> 1 acetate and washed with 1 molar hydrochloric acid (x2), dried and evaporated Crystallization from acetic acid afforded the title compound (160 mg, 40%) 1H NMR (400 MHz, DMSO-rf6 ) δ ppm 13.13 (br s, 1 H), 12.50 (s, 1 H), 12 03 (br s, 1 H), 4 71 (m, 1 H), 4 35 (d, J=5 05 Hz, 2 H), 3 84 (t, .J=7.20 Hz, 2 H), 2.10-2 38 (m, 4 H), 1 80 (d, J=12 63 Hz, 2 H), 1 42 - 1 71 (m, 7 H), 1.21 - 1.42 (m, 4 H), 1.01-122 (m, 1 H) Example 95 (Formula Removed) N-({ l-Cyclohexyl-34(3.4-dichlorophenyl)methyll-6-hydroxy-2.4-dioxo-1,2.3.4-tetrahydro-5- pynmidinyl} carbonyl )glvcine A mixture of ethyl N-[(l-cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pynmidinyl)carbonyl]glycinate (340 mg, 1 0 mmoles), pulv potassium carbonate (750 mg, 5 35 mmoles) and 3,4-dichlorobenzyl bromide (480 uL, 2 0 mmoles) in dimethylacetamide (5 mL) was vigorously stirred at 100°C for 3 hours. The mixture was poured into 1 molar hydrochloric acid and extracted with ethyl acetate (x2) The combined organic solutions were washed with 1 molar hydrochloric acid and evaporated. The residue was purified by flash chromatography (10-50% ethyl acetate m hexane), the required fractions evaporated, dissolved in ethanol (5 mL) and 1 molar sodium hydroxide solution (3 0 mL) added The mixture was stirred overnight, acidified and extracted with ethyl acetate (x2), the combined extracts washed with 1 molar hydrochloric acid, dried and evaporated. Recrystallization from ethanol-water gave the title compound (154 mg, 33%). 1H NMR (400 MHz, DMSO-J6) δ ppm 13 11 (br s. 1 H), 10 12 (br s.. 1 H), 7 58 (dd, J=5 05, 3 03 Hz, 2 H), 7 29 (dd, J=8 34, 2 02 Hz, 1 H). 4 97 (s, 2 H), 4 62 ft. J=12 00 Hz, 1 H), 4 13 (d, J=5.81 Hz, 2 H), 2.24 (q, 2 H), 1 78 (d, J=12 63 Hz, 2 H), 1 63 (s. 3 H), 1.27 (q, J=12 88 Hz, 2 H), 1 11 (q, 1 H) Example 96 (Formula Removed) N-IYl -Cyclohexyl-6-hydroxy-2.4-dioxo-1,2,3,4-tetrahydro-5-pynmidinyl)carbonyllglycme Ethyl N-[(l-cyclohexyl-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pynmidinyl)carbonyl]glycinate (270 mg, 0 80 mmol)) was dissolved m ethanol (2 mL) and IM aqueous NaOH solution was added. The solution was stirred one hour at room temperature, then neutralized by addition of IM aqueous HCl The resulting sohd was collected, washed with water, and dned under vacuum overnight to give the title compound (208 mg, 84%). LC/MS m/z 312 (M+H*). Example 97 (Formula Removed) N-({3-Cyclohexyl-6-hydroxy-l-[trans-4-fmethyloxykvclohexyll-2.4-dioxo-1.2.3.4-tetrahydro-5- pynmidmyl} carbonyl Iglvcine Using Imn5'-4-(methyloxy)cyclohexanamine hydrochlonde m place of 4-methylcyclohexylamine, the title compound was prepared in 11% yield (541 6 mg) following the procedures described in example 54. IH NMR (400 MHz, CDCh) δ ppm 1 12 - 1 50 (m, 6 H) 1 56 - 1 77 (m, 6 H) 1.78 - 1 90 (m, 2 H) 2 09 - 2 22 (m, 2 H) 2 25 - 2 55 (m, 4 H) 3 18 - 3 31 (m, 1 H) 3 37(s, 3 H) 4.22 (d, J=5 3 Hz, 2 H) 4 62-4 89 (m, 2 H) 10 22- 10 41 (m, 1 H) Example 98 (Formula Removed) N-({l-|"l.r-Bi(Cyclohexyl)-4-vn-3-Cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5- pynmidmyl} carbonyl)glycine Using l,l'-bi(cyclohexyl)-4-amme hydrochlonde in place of 4-methylcyclohexylamine, the title compound was prepared in 19% yield (84 mg) following the procedures described m example 54 IH NMR (400 MHz, CDC13) S ppm 0 88 - 1 43 (m, 13 H) 1 56 - 1 76 (m, 11 H) 1 76 - 1 91 (m, 4 H) 2.26 - 2.43 (m, 4 H) 4.24 (d, J=5.8 Hz, 2 H) 4 59 - 4 82 (m, 2 H) 10 24 - 10 38 (m, 1 H) Example 99 (Formula Removed) N- {[6-Hvdroxy-2.4-dioxo-1,3-bis( 1 -propylburyl)-1.2 3,4-tetrahydro-5~ pynmidinyllcarbonyl} glycine 99a) N,N-Bis( 1 -propylbutyDurea A mixture of carbonyldiimidazole (3 0 g, 18 5 mmoles) and 4-heptylamine (6.0 mL, 40 mmoles) in dimethylformamide (25 mL) was heated at 70°C for 3 hours The mixture was cooled and partitioned between ethyl acetate and 1 molar hydrochloric acid. The aqueous was extracted with ethyl acetate and the combined extracts washed with 1 molar hydrochloric acid, dried and evaporated to a solid (4 18 g, 88%) 1H NMR (400 MHz, DMSO-d6) δ ppm 5 34 (d, J=8.59 Hz, 2 H), 1 12 - 1 38 (m, 16 H), 0 85 (t, .J=6 19 Hz, 12 H) 99b) 1.3-Bis(l-propylbutyl)-2,4,6(1H,3H,5H)-pyrimidmetrione. N,N-bis( 1 -propylbutyl)urea (1 87 g, 7 29 mmoles) m chloroform (70 mL) was treated with malonyl dichloride (851 uL, 8 75 mmoles) and heated at 70°C for 3 hours The mixture was washed with 1 molar hydrochloric acid (x2), dned and evaporated. Flash chromatography (hexane - 50% ethyl acetate in hexane) gave the title compound (660 mg, 28%) 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 4 78 (s, 2 H), 3 61 (s, 2H), 1.94 - 2.04 (m, 4 H), 1.58-1 67 (m, \ H), 1 17- 1 28 (m, 8 H), 0 90 (t, .J=7 33 Hz, 12 H) 99c) N-{ri.3-Bisfl-ethylpropylV6-hydroxy-2.4-dioxo-1.2.3.4-tetrahydro-5-pyrimidinyl]carbonvUglycine. A mixture of l,3-bis(l-ethylpropyl)-2,4,6(1H,3H,5H)-pynmidmetnone (660 mg, 2.0 mmoles) and and dusopropylethy(amine (690 uL, 4.0 mmoles) in dichloromefhane (50 mL) was treated with ethyl isocyanatoacetate (270 uL, 2 4 mmoles) and stirred overnight. The mixture was washed with 1 molar hydrochloric acid (x2), dned and evaporated. The residue was dissolved m ethanol (6 mL) and treated with 6 molar sodium hydroxide (4.0 mL). The mixture was stirred for 72 hour, acidified and extracted with ethyl acetate (x2), dned and evaporated. The residue was stored at -10°C overnight to crystallize The solid produced was slurned m hexane, collected and washed with hexane to give the title compound (310, 36%). 1HNMR (400 MHz, DMSO-d6) δ ppm 13 09 (s, 1 H), 10 19 (d,.J=21.47 Hz, 1 H), 4.82 (s, 2 H), 4.12 (d, .J=3.54 Hz, 2 H), 2.02 (s, 4 H), 1 58 (s, 4 H), 1.16 (s. 8 H), 0.84 (t, .J=7 33 Hz, 12 H) Example 100 (Formula Removed) N-({3-(2-Cydopropylethyl)-6-hydroxy-l-r3-(methyloxy)phenyl]-2.4-dioxo-1.2.3.4-tetrahydro-5- pynmidinyl) carbonyl)glycine 100a) l-(2-Cyclopropylethyl)-3-(r3-rmethyloxy)phenyllmethylh2.4.6(1H,3H,5H)-pyrimidinetnone. Cyclopropylethylamme hydrochlonde (2 0 g, 16 44 mmoles) in dichloromethane (60 mL) was treated with diisopropylethylamine (2 84 mL, 16.44 mmoles) followed by 3-methoxyphenyl isocyanate (2 12 mL, 16 44 mmoles) The mixture was stirred for 1 hour, malonyl dichloride (1 92 mL, 19.73 mmoles) was added and the mixture heated under gentle reflux for 4 hours. The mixture was washed with 1 molar hydrochloric acid and purified by flash chromatography (hexane to 30% ethyl acetate in hexane) to give the title compound which was obtained as a solid from hexane-diethyl ether (2 12 g, 42%) 1HNMR (400 MHz, DMSO-d6) δ ppm 7 37 (t, .J=8.21 Hz, 1 H), 6 94 - 7 12 (m, 1 H), 6 69 - 6 88 (m. 2 H). 3 86 (Formula Removed) N-{[3-CyclohexyI-6-hydroxy-2.4-dioxo-1 -(4-phenylCyclohexyl)-1,2,3,4-tetrahydro-5~ pynmidmvllcarbonyl] glycine Using 4-phenylcyclohexylamme in place of 4-methylcyclohexylamme, the title compound was prepared in 29% yield (173 mg) following the procedures described m example 54 1H NMR (400 MHz, CDC13) δ ppm 1.16 - 1.44 (m, 4 H) 1 56 - 1 91 (m, 8 H) 1 95 - 2 07 (m, 3 H) 2 27 - 2 43 (m, 2 H) 2 51 - 2.68 (m, 4 H) 4.26 (d, J=5 6 Hz, 2 H) 4 65 - 4.96 (m, 2 H) 7.15 7 25 (m, 3 HI 7 27 - 7.35 (m, 2 H) 10.27 - 10 38 (m, 1 H) Example 102 (Formula Removed) N-(n-Cyclohexyl-3-[r3.4-difluorophenyl)methyll-6-hydroxy-2.4-dioxo-1.2.3.4-tetrahydro-5- pynmidinyl} carbonynglvcme A mixture of ethyl N-[( 1 -cyclohexyl-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycmate (340 mg, 1 0 mmoles), puh potassium carbonate (750 mg, 5 35 mmoles) and 3,4-difluorobenzyl bromide (256 uL, 2 0 mmoles) m dimethylacetamide (5 mL) was vigorously stirred at 100°C for 3 hours The mixture was poured into 1 molar hydrochloric acid and extracted with ethyl acetate (x2) The combined organic solutions were washed with 1 molar hydrochloric acid and evaporated. The residue was purified by flash chromatography (10-50% ethyl acetate in hexane), the required fractions evaporated, dissolved in ethanol (5 mL) and 1 molar sodium hydroxide solution (3 0 mL) added The mixture was stirred overnight, acidified and extracted with ethyl acetate (x2), the combined extracts washed with 1 molar hydrochloric acid, dried and evaporated. Recrystallization from ethanol-water gave the title compound (138 mg, 32%). 1HNMR(400 MHz, DMSO-rf6) δ ppm 13 11 (br. s.lH), 10 12 (br s , 1 H), 7 28 - 7 52 (m, 2 H), 7 05 - 7.23 (m, .J=5.43, 3 16 Hz, 1 H), 4 96 (s, 2 H), 4 63 (t, J=12 00 Hz, 1 H), 4 13 (d,.J=5 81 Hz, 2 H), 2.25 (q, 2 H), 1 78 (d,.J=12 88 Hz, 2 H), 1.63 (s, 3 H), 1 28 (q, J=12.97 Hz, 2 H), 1 11 (q, 1 H) Example 103 (Formula Removed) N-({3-(2-Cyclopropylethyl)-6-hydroxy-l-r4-(methyloxy)phenyl]-2.4-dioxo-1.2.3.4-tetrahydro-5- pynmidmvl }carbonyl)glvcme 103a) l-(2-Cyclopropylethyl)-3- {r4-(methyloxy)phenyllmethyl t -2,4.6( IH.3H.5H)-pynmidinetnone. Cyclopropylethylamme hydrochlonde (1 62 g, 13 32 mmoles) in chloroform (80 mL) was treated with diisopropylethylamine (2 3 mL, 13 32 mmoles) followed by 4-methoxyphenyl isocyanate (1 73 mL, 13 32 mmoles) The mixture was stirred for 2 hours, malonyl dichloride (1.55 mL, 16 0 mmoles) was added and the mixture heated at 43°C for 4 hours. The mixture was washed with 1 molar hydrochloric acid and purified by flash chromatography (hexane to 35% ethyl acetate m hexane) to give the title compound which was obtained as a solid from hexane-diethyl ether (2 2 g, 54%) 1H NMR (400 MHz, DMSO-d6) δ ppm 7.13 (d, 2 H), 7.00 (d, J=9 09 Hz, 2 H), 3.85 (s, 2 H), 3 80 - 3 84 (m, 2 H), 3.79 (s, 3 H), 1 42 (q, J=7 07 Hz, 2 H), 0 62 - 0.77 (m, 1 H), 0.36 - 0 44 (m, 2 H), -0 00 - 0 06 (m, 2 H) 103b) N-((3-(2-Cyclopropylethyl)-6-hydroxy-l-r4-rmethyloxy)phenyll-2.4-dioxo-1.2.3.4-tetrahydro-5-pyrimidinyllcarbonyl)glvcme A mixture 1 -(2-eyclopropylethyl)-3- {[4-(methyloxy)phenylJmethyl}-2,4,6(1H,3H,5H)-pynmidmetnone (2 2 g, 7 27 mmole) and and diisopropylethylamine (2 50 mL, 14.5 mmoles) m dichloromethane (80 mL) was treated with ethyl isocyanatoacetate (979 uL, 8.7 mmoles) and stirred overnight. The mixture was washed with 1 molar hydrochloric acid (x2), dried and evaporated The residue was dissolved in ethanol (6 mL) and treated with 6 molar sodium hydroxide (5 0 mL) The mixture was stirred for 2 hours, acidified and extracted with ethyl acetate (x2), dried and evaporated The residue was purified by flash chromatography (1.0% methanol - 0.1 % acetic acid m dichloromethane to 3 0% methanol-0.1 % acetic acid in dichloromethane) to give the title compound (1 3 g, 44%) 1H NMR (400 MHz, DMSO-J6)§ppm 13 10 (s, 1 H), 10 08 (s, 1 H), 7 21 (d, J=5 31 Hz, 2 H), 6.97 - 7 04 (m, 2 H), 4.13 (d, J=5.81 Hz, 2 H), 3.89 - 3 97 (m, 2 H), 3.80 (s, 3 H), 1.48 (q, .7-6 91 Hz, 2 H), 0 64 - 0.74 (m, J=15.22, 12 25, 7.39, 5 05 Hz. 1 H), 0 41 (ddd, J=7 96. 5 68. 4 04 Hz, 2 H), 0 02 (td. J=5 18, 4 29 Hz, 2 H) Example 104 (Formula Removed) N-([3-(2-Cyclopropylethyl)-6-hydroxy-l-(3-mtrophenylV2,4-dioxo-l,2.3.4-tetrahydro-5- pynmidinyllcarbonyl} glycine 104a) l-(2-Cyciopropylethyl)-3-(3-mtrophenyl)-2.4.6(1H.3H,5H)-pyrimidmetrrone. Cyclopropylethylamrne hydrochloride (1 62 g, 13.32 mmoles) m chloroform (80 ml.) was treated with diisopropylethylamine (2 3 mL, 13 32 mmoles) followed by 3-rutrophenyl isocyanate (2 19 g, 13 32 mmoles). The mixture was stirred for 2 hours, malonyl dichlonde (1 55 mL, 16 0 mmoles) was added and the mixture heated at 43°C for 4 hours The mixture was washed with 1 molar hydrochlonc acid and purified by flash chromatography (hexane to 50% ethyl acetate m hexane) to give the title compound (1 66 g, 40%) IH NMR (400 MHz, DMSO-d6) δ ppm 8 27 - 8 36 (m, 1 H), 8.22 (t, J=2 02 Hz, 1 H), 7 80 (d, J=8 08 Hz, 1 H), 7 71 - 7.77 (m. 1 H), 3 90 (s, 2 H), 3 84 (t, 2 H), 1.44 (q,J=7 16 Hz, 2 H), 0 62 - 0 80 (m. 1 H), 0 31 - 0 47 (m, 2 H), 0 05 (q..J=4 80 Hz, 2 H) 104b) N-{[1-(2-Cyclopropylethyl)-6-hydroxy-3-f3-nitrophcnyl)-2,4-dioxo-1.2,3,4-tetrahydro-5-pyrimidinyncarbonyl\glycine A mixture l-(2-cyclopropylethyl)-3-(3-mtrophenyl)-2,4,6(1//,3H,5H)-pyrimidinetrione (1.66 g, 5 23 mmole) and and diisopropylethylamine (1 80 mL, 10.5 mmoles) in dichloromethane (80 mL) was treated with ethyl isocyanatoacetate (704 uL, 6 27 mmoles) and stirred overnight The mixture was washed with 1 molar hydrochlonc acid (x2), dried and evaporated. The residue was dissolved m ethanol (6 mL) and treated with 6 molar sodium hydroxide (5.0 mL) The mixture was stirred for 1 hour, acidified and extracted with ethyl acetate (x2), dried and evaporated. A solid was obtained from acetic acid-water, which was purified by trituration in boiling chloroform to give the title compound (800 mg, 37%). IH NMR (400 MHz, DMSO-d6) δ PP™ 13 12 (br s, 1 H), 10 03 (s. 1 H), 8 35 (s. 1 H), 8 32 (ddd, J=8 40, 1.64, 1 33 Hz, 1 H), 7 82 - 7 88 (m, 1 H), 7 79 (t, J=8 08 Hz, 1 H), 4 14 (d, J=-5 81 Hz, 2 H), 3 88 -3.97 (m, 2 H), 1.50 (q, J=7 16 Hz, 2 H), 0 66 - 0 76 (m, 1 H), 0 42 (ddd,.J=7 96, 5 68, 4 04 Hz, 2 H), 0 05 (td, J=S 18, 4 29 Hz, 2 H) Example 105 (Formula Removed) N-( (3-("2-Cyclopropylethyl)-6-hydroxy-2.4-dioxo- l-[4-(2-thienyl^phenyl1-1.2.3.4- tetrahydro-5-p ynmidmyl 1 c arbonyl) glycine 105a) l-r2-CyciopropylemvlV3-r4-(2-thienynphenyl1-2.4.6fm,3H.5H)-pyrimidinetrione. Cyclopropylethylamine hydrochloride (608 mg, 4 96 mmoles) in chloroform (50 mL) was treated with diisopropylethylamme (2 1 mL, 12 0 mmoles) followed by 2-(4-isocyanatophenyl) thiophene (1.0 g, 4 96 mmoles) The mixture was stirred for 2 hours, malonyl dichlondc (583 uL, 6 0 mmoles) was added and the mixture heated at 63°C for 2 hours The mixture was washed with 1 molar hydrochloric acid and purified by flash chromatography (0-4 0% methanol in dichloromethane) to give the title compound (630 mg, 36%) 1H NMR (400 MHz, DMSCM6) δ ppm 7 75 (d, J=8 59 Hz, 2 H), 7 61 (dd, J=5 05, 1 26 Hz, 1 H), 7 57 (dd. J=3 54, 1.01 Hz, 1 H), 7 27 (d, .J=8 59 Hz, 2 H), 7 18 (dd, J=5 18, 3 66 Hz. 1 H), 3 89 (s, 2 H). 3 84 (t, 2 H), 1 44 (q, 2 H), 0.63 - 0 76 (m, 1 H), 0 37 - 0 46 (m. 2 H), 0 05 (q, J=4 80 Hz, 2 H ) 105b) N-( (3-(2-Cyclopropylethyl)-1 -[4-(2-thienynphenyll-6-hydroxy-2.4-dioxo-l .2.3.4-tetrahydro-5-pyrmidinyllcarbonyl)glvcine A mixture of 1 -(2-cyclopropylethyl)-3-[4-(2-thienyl)phenyl]-2,4,6(1H,3/f,5H)-pyrimidinetnone (630 mg, 1.78 mmoles) and and diisopropylethylamme (616 uL, 2 13 mmoles) in dichloromethane (50 mLI was treated with ethyl isocyanatoacetate (239 uL, 2.13 mmoles) and stirred overnight The mixture was washed with 1 molar hydrochloric acid (x2), dried and evaporated The residue was dissolved in ethanol (5 mL) and treated with 6 molar sodium hydroxide (2 0 mL) The mixture was stirred for 2 hour, acidified and extracted with ethyl acetate (x2), dried and e\ aporated Flash chromatography (dichloromethane to 3 5% methanol-0.1% acetic acid) gave the title compound which was recrystallized from dichloromethane (3 00 mg, 3 7%) 1H NMR (400 MHz, DMSO-d6) δ ppm 13 11 (s, 1 H), 10.07 (s, 1 H), 7 75 (ddd, J=8.72, 2 53, 2 15 Hz, 2 H), 7.60 (ddd, J=9 79, 4 36, 1 01 Hz, 2 H), 7.36 (d, J=6 82 Hz, 2 H), 7 18 (dd, .J=5.05, 3 54 Hz, 1 H), 4 14 (d, J=5 81 Hz, 2 H), 3 90 - 3.99 (m, 2 H), 1.50 (q, J=l 07 Hz, 2 H), 0 65 - 0 75 (m, 1 H), 0 42 (ddd, J-=7 96, 5 68, 4 04 Hz, 2 H), 0 03 (td, J=5.18, 4.29 Hz, 2 H) Example 106 (Formula Removed) N-{[ 1 3-Bis( 1 -ethylnropyl)-6-hydroxy-2.4-dioxo-1,2.3.4-tetrahydro-5-pyrimidinyncarbonyl} glycine 106a) NN-Bis( 1 -ethylpropyDurea A mixture of carbonyldiimidazole (3 0 g, 18.5 mmoles) and 3-aminopentane (4.66 mL, 40 mmoles) in dimethylformamide (25 mL) was heated at 70°C for 3 hours The mixture was cooled and partitioned between ethyl acetate and 1 molar hydrochlonc acid The aqueous was extracted with ethyl acetate and the combined extracts washed with 1 molar hydrochloric acid, dried and evaporated to a solid (3 6 g, 97%). 1H NMR (400 MHz, DMSO-d6) δ ppm 5 37 (s, 2 H), 1.55 (q, J=7.33 Hz, 4 H), 1 13 (s, 12 H), 0 76 (t. .J=7 45 Hz, 6 H) 106b) 1.3-Bis(l-ethylpropyl)-2.4.6( 1H,3H,5H)-pynmidinetnone N,N-bis(l-ethylpropyl)urea (1 03 g, 5 15 mmoles) in chloroform (60 mL) was treated with malonyl dichlonde (600 uL, 6 2 mmoles) and heated at 70°C for 3 hours The mixture was washed with 1 molar hydrochlonc acid (x2), dned and evaporated. Flash chromatography (hexane - 50% ethyl acetate in hexane) gave the title compound (540 mg, 39%). 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 4.45 - 4.76 (m, 2 H), 3.66 (s, 2 H), 1.91 - 2 14 (m, 4 H), 1 55 - 1 87 (m, 4 H). 0 85 (t, j=7 45 Hz, 12 H) 106c) N-{[13-Bis(l-ethylpropyl)-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyllcarbonvUglycine. A mixture of l,3-bis( l-ethylpropyl)-2,4,6( 1H,1H,SH)-pyrimidinetrione (540 mg, 2.0 mmoles) and and diisopropylethylamme (690 uL. 4.0 mmoles) in dichloromethane (50 mL) was treated with ethyl isocyanatoacetate (270 uL, 2 4 mmoles) and stirred overnight. The mixture was washed with 1 molar hydrochlonc acid (x2), dned and evaporated. The residue was dissolved in ethanol (6 mL) and treated with 6 molar sodium hydroxide (4.0 mL). The mixture was stirred for 72 hour, acidified and extracted with ethyl acetate (x2), dned and evaporated The residue was stored at -10°C overnight, crystallized The solid was slurried m hexane, collected, washed with hexane to give the title compound (300 mg, 40%) 1H NMR (400 MHz, DMSO-d6) δ ppm 13 10 (br s, 1 H), 10 20 (br s, 1 H), 4 65 (br s, 2 H), 4 13 (d, J=5 81 Hz, 2 H), 2.02 (br s, 4 H), 1.69 (br s, 4 H), 0 77 (t, .J=7 33 Hz, 12 H) Example 107 (Formula Removed) N-[(6-Hydroxy-2,4-dioxo-l,2,3.4-tetrahydro-5-pyrimidinyl)carbonynglvcine Barbitunc acid (512 mg. 4 mmol) was dissolved m a mixture of dichloromefhane (3 mL) and DMF (5 mL). TV.N-Diisopropylethylamme (2 mL) was added followed by ethyl isocyanatoacetate (645 mg, 5 mmol) and the solution was stirred overnight. After evaporation of all volatiles, the residue was re-dissolved in a mixture of ethanol (5 mL) and IM aqueous NaOH (5 mL). After stirring at room temperature for one hour, this solution was neutralized by addition of IM aqueous HC1 The resulting solid was collected, washed with water, and dried under vacuum overnight to give the title compound (202 mg, 22%) LC/MS m/z 230 (Mb-H+) Example 108 (Formula Removed) N-F( l-Cyclohexyl-6-hydroxy-2.4-dioxo-3-{r4-(trifluoromethyl)phenynmethyU-1.2,3,4-tetrahydro-5 -pyrimidinyl )carbonyl 1 glycine A mixture of ethyl N-[(l-cyclohexyl-6-hydroxy-2,4-dioxo-l,2.3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycinate (340 mg, 1 0 mmoles), puH potassium carbonate (750 mg, 5 35 mmoles) and 4-tnfluoromethylbenzyl bromide (478 uL. 2 0 mmoles) in dimethylacetamide (5 mL) was vigorously stirred at 100°C for 3 hours The mixture was poured into 1 molar hydrochloric acid and extracted with ethyl acetate (x2). The combined organic solutions were washed with 1 molar hydrochloric acid and evaporated The residue was purified by flash chromatography (10-50% ethyl acetate in hexane), the required fractions evaporated, dissolved in ethanol (5 mL) and 1 molar sodium hydroxide solution (3.0 mL) added The mixture was stirred overnight, acidified and extracted with ethyl acetate (x2), the combined extracts washed with 1 molar hydrochloric acid, dried and evaporated Recrystallization from ethanol-water gave the title compound (176 mg, 37.5%). 1HNMR (400 MHz, DMSO-d6) δ ppm 13 10 (br s., 1 H), 10 13 (br s , I H), 7 69 (d, .J=8.08 Hz, 2 H), 7 51 (d, J=8 08 Hz, 2 H), 5 07 (s, 2 H), 4 64 (t, .J= 12 13 Hz, 1 H), 4 13 (d, J=5 81 Hz, 2 H), 2.13 - 2.32 (m, 2 H), 1 78 (d, J=12 63 Hz, 2 H). 1 50 - 1.72 (m, 3 H), 1 28 (q, 2 H), 1 11 (q, J=13 22 Hz, 1 H). Example 109 (Formula Removed) N-[( 1.3-Dibutvl-6-hydroxy-2.4-dioxo-1.2.3.4-tetrahydro-5 -pynmidrnyl IcarbQnyl] glycine 109a) 1.3-Dibutyl-2.4.6(l/f.3/f.5H)-pyrimidinetrione 1-Butyhsocyanate (2.25 ml, 20 mmoles) and butylamine (1.98 mL, 20 mmoles) were stirred together in dichloromethane (100 mL) for 2 hours. Malonyl dichloride (2 14 mL, 22 mmoles) was added and the mixture was heated under gentle reflux for 2 hours. The mixture was washed with 1 molar hydrochloric acid (x2), dned and evaporated. Flash chromatography (hexane - 25% ethyl acetate-hexane) gave the title compound (1.32 g, 27%). IHNMR (400 MHz, DMSO-76) δ ppm 3 65 - 3 77 (m, 6 H), 1 48 (tt, 4 H), 1.28 (tq, J=7 49, 7 33 Hz, 4 H), 0.89 (t, J=7 33 Hz, 6 H) 109b) N-['(1,3-Dibutvl-6-hyuroxy-2.4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl)carbonynglvcine A mixture of l,3-dibutyl-2,4,6(1H,3H,5H)-pyrimidmetrione (1 3 g mg, 5 5 mmoles) and diisopropylethylamine (1.9 mL, 11 0 mmoles) in dichloromethane (20mL) was treated with ethyl isocyanatoacetate (673 uL, 6 0 mmoles) and stirred for 24 hours The mixture was washed with 1 molar hydrochloric acid (x2), dned and evaporated. The residue was taken up m ethanol (5 mL) and treated with 6 molar sodium hydroxide (3 mL) and stirred for 2 hours The mixture was acidified with 1 molar hydrochloric acid and stirred for 30 minutes to give a solid which was recrystallized from acetic acid-water to afford the title compound (1 2 g, 64%) 1H NMR (400 MHz,DMSO-d6) δ ppm 13.10(br. s, 1 H) 10 11 (t,J=6 19Hz, 1 H), 4 13 (d,J=5 81 Hz, 2 H), 3 81 (t, 4 H), 1 43 - 1 63 (m, 4 H), 1 14-141 (m, 4 H), 0 89 (t, J=7 33 Hz, 6 H) Example 110 Formula Removed) N-{[1.3-Bis(2-Cyclopropylethyl)-6-hydroxy-2.4-dioxo-1.2.3.4-tetrahydro-5-pyrimidinyl'lcarbonyl} glycine 110a) yVN-Bis(2-Cyclopropylethyl)urea A mixture of eyelopropylethylamrne hydrochloride (5.15 g, 42 35 mmoles), sodium carbonate (4.56 g, 43 mmoles) and carbonyldnmidazole (2.99 g, 18 4 mmoles) in dimethylformamide (30 mL) was sealed in a pressure flask and heated at 100°C for 2 hours The mixture was acidified with 1 molar hydrochloric acid and extracted into ethyl acetate (x2) The combined extracts were washed with 1 molar hydrochloric acid, dried and evaporated to give the title compound (3 28 g, 79%) 1H NMR (400 MHz, DMSO-d6) δ ppm 5.77 (br s., 2 H), 3.03 (t, J=6 95 Hz, 4 H), 1 25 (q. J=l 07 Hz, 4 H), 0 50 - 0 76 (m, 2 H), 0 26 - 0 48 (m, 4H),-0 17-0 16(m,4H) 110b) 1.3-Bis(2-Cyclopropylethyl)-2.4.6(1H.3tf,5H)-pynmidmetnone Malonyl dichlonde (2 02 mL, 20.8 mmoles) was added to a solution of iV,N-bis(2-cyclopropylethyl)urea (3 26 g, 16 6 mmoles) m dichloromethane (200 mL) and the mixture was heated under gentle reflux for 2 hours The mixture was washed with 1 molar hydrochloric acid, evaporated and purified by flash chromatography (hexane - 25% ethyl acetate-hexane) gave the title compound (1 05 g, 24%) 1H NMR (400 MHz, CHLOROFORM-tf) δ ppm 3 94 (t, 4 H). 3 61 (&, 2 H), 1 46 (q, 4 H), 0 55 - 0 75 (m, 2 H), 0 33 - 0.49 (m, 4 H), -0 04 - 0 08 (m, 4 H) 110c) N-{n.3-Bis(2-Cyclopropylethyl)-6-hydroxy-2,4-dioxo-L2,3.4-tetTahydro-5-pyrimidinyl]carbQnvUglycine A mixture of l,3-bis(2-cyclopropylethyl)-2,4.6(1H,3H,5iT0-pyrimidinernone (1 05 g, 3.97 mmoles) and dnsopropylethylamme (151 mL, 8 7 mmoles) m dichloromethane (50mL) was treated with ethyl isocyanatoacetate (980 uL, 8 7 mmoles) and stirred overnight The mixture was washed with 1 molar hydrochloric acid (x2), dried and evaporated The residue was taken up in ethanoi (6 mL) and treated with 6 molar sodium hydroxide (4 mL) and stirred for 2 hours The mixture was acidified with 1 molar hydrochloric acid and stirred for 30 minutes to give a solid which was recrystalhzed from acetic acid-water to afford the title compound (1.1 g, 76%). 1H NMR (400 MHz, DMSO-rf6) δ ppm 13 09 (br. s, 1 H). 10.10 (t, J=5.81 Hz, 1 H), 4 13 (d, J=5 81 Hz, 2 H), 3 86 - 3 95 (m, 4 H), 1 45 (q, .J=7 07 Hz, 4 H), 0 62 -0 72 (m, J=15 13, 12 28, 7 33, 4 93 Hz, 2 H), 0 38 (ddd,.J=7 96, 5 68. 4 04 Hz, 4 H), -0 00 (q, J=4.80 Hz, 4 H) Example 11 1 (Formula Removed) N-{[6-Hvdroxy-l,3-bis('2-methylpropyl)-2,4-dioxo-1,2,3.4-tetrahydro-5-pynmidinyl]carbonyl} glycine Ilia) ?\^N-Bis(2-methylpropyl)urea A mixture ofisobutylamine (3.98 mL, 40 mmoles) and carbonyldiimidazole (3 0 g, 18 5 mmoles) in dunethylformarmde (6 mL) was sealed m a pressure flask and heated at 75°C for 2 hours The mixture was acidified with 1 molar hydrochloric acid and extracted mto ethyl acetate (x2) The combined extracts were washed with 1 molar hydrochloric acid, dried and evaporated to give the title compound (3 2 g, 93%) IH NMR (400 MHz, DMSO-40 5 ppm 5 79 (br s , 2 H), 2 81 (d, J=6 82 Hz. 4 H), 1 59 (dq, .J=13.39, 6 69 Hz, 2 H), 0.82(d,J=6 82Hz, 12 H) 111b) 1.3-Bi8(2-methylpropyl)-2.4,6(1H,3H,5H)-pynmidinetnone Malonyl dichlonde (2 2 mL, 22.3 mmoles) was added to a solution of vV,N-bis(2-methylpropyl)urea (3 2 g, 18 6 mmoles) m dichloromethane (175 mL) and the mixture was heated under gentle reflux for 2 hours The mixture was washed with 1 molar hydrochloric acid, evaporated and purified by flash chromatography (hexane - 25% ethyl acetate-hexanej gave the title compound (3 38 g, 76%) IH NMR (400 MHz, CHLOROFORM-d) δ ppm 3 75 (d, J=7 33 Hz, 4 H). 3 70 (s, 2 H), 2 07 (dq, J=13 89, 7 07 Hz, 2 H), 0.92 (d, J=6 82 Hz, 12 H) 111c) N- (r6-Hydioxy-1,3-bis(2-methylpropyl )-2,4-dioxo-1,2.3,4-tetrahydro-5 -pyrimidinyllcarbonyl}glycine. A mixture of l,3-bis(2-methylpropyl)-2.4,6(1H,3iir,5iy)-pynmidmetnone (3.3 g, 13.73 mmoles) and dnsopropylethylamine (5 2 mL, 30 mmoles) in dichloromethane (lOOmL) was treated with ethyl isocyaiiatoacetate (3 36 mL, 30 mmoles) and stirred overnight. The mixture was washed with 1 molar hydrochloric acid (x2). dried and evaporated to a solid which was slurried in hexane and collected The solid was taken up in ethanol (10 mL) and treated with 6 molar sodium hydroxide (6 mL) and stirred for 2 hours. The mixture was acidified with 6 molar hydrochloric acid and diluted with 6 molar hydrochloric acid stirred for 30 minutes to give a solid which was recrystalhzed from acetic acid-water to afford the titfe compound (3 15 g, 67%) IH NMR (400 MHz, DMSO-d6) δ ppm 13 11 (br. s, 1 H), 10 13 (t, J=5.81 Hz, 1 H), 4 13 (d, J-5 81 Hz, 2 H), 3 67 (d,.J=7 33 Hz, 4 H). 2 02 (dq,J-l3 80, 6 92 Hz, 2 H), 0.85 (d, .J=6 82 Hz, 12 H) Example 112 (Formula Removed) N-({3-r2-CycloprQpylethyl)-6-hydroxy-l-[3-(5-methyl-1.2.4-oxadiazol-3-vl')pheBvl]-2.4-dioxo-1.2.3.4-tetrahydro-5-pyrimidinvUcarbonyl)glvcine 112a) l-(2-Cyclopropylethyn-3-r3-('5-methyl-1.2.4-oxadiazol-3-vnphenyll-2.4.6(1H,3H,5H)-pyrimidinetrione. Cyclopropylethylamme hydrochlonde (588 mg, 4 84 mmoles) in chloroform (50 mL) was treated with dhsopropylethylamine (2 1 mL, 12 0 mmoles) iollowed by 3-(3-isocyanatophenyl)-5-methyl-l,2,4-oxadiazole (973 mg, 4 84 mmoles) The mixture was stirred for 2 hours, malonyl dichlonde (583 uL, 6 0 mmoles) was added and the mixture heated at 63"C for 2 hours The mixture was washed with 1 molar hydrochloric acid and purified by flash chromatography (0-4 0% methanol in diehloromethane) to give the title compound (425 mg, 25%) 1H NMR (400 MHz, CHLOROFORM-^/) δ ppm 8 19 (ddd, J=7 96, i 39, I 26 Hz, 1 H), 7 95 (t, .J=1.77 Hz, 1 H), 7.64 (t, J=8.08 Hz, 1 H), 7 36 (ddd, .7-7 90. 2 15, 1 01 Hz, 1 H), 4 03 - 4 09 (m, 2 H), 3 89 (s, 2 H), 2.68 (s, 3 H), 1 54 - 1 57 (m, 1 H). 0 67 - 0 77 (m, 1 H). 0 46 - 0 52 (m, 2 H), 0 10 (td, J=5 24, 4.42 Hz, 2 H) H2b) N-( (3-Q-Cyclopropylethyl)-6-hydroxy-1 -r3-(5-methyl-1.2.4-oxadiazol-3-vl)phenyl 1-2.4-dioxo-1.2.3.4-tetrahydro-5-pyrimidinyllcarbonvDglycme A mixture of l-(2-cyclopropylethyl)-3-[3-(5-methyl-l,2,4-oxadiazol-3-yl)phenyl]-2,4,6(17/,3H,5H)-pyrimidmetnone(418 mg, 1 18 mmoles) and and diisopropylethylamme (408 uL, 2 36 mmoles) m diehloromethane (50 mL) was treated with ethyl isocyanatoacetate (160 uL, 1 41 mmoles) and stirred overnight The mixture was washed with 1 molar hydrochloric acid (x2), dried and evaporated The residue was dissolved in ethanol (5 mL) and treated with 6 molar sodium hydroxide (2 0 mL) The mixture was stirred for 2 hour, acidified and extracted with ethyl acetate (x2), dried and evaporated Flash chromatography (diehloromethane to 3 5% methanol-0.1% acetic acid) gave the title compound which was recrystallized from acetic acid - water (290 mg, 54%) 1H NMR (400 MHz, DMSO- Example 113 (Formula Removed) N-r{3-r2-Cyclopropylethyl)-6-hydroxy-l-r4-(2-methyl-1,3-thiazol-4-vl)phenyll-2,4-dioxo-1,2,3,4- terjahydro-5-pyrrmidinvUcarbonyl)glvcine 113a) l-(2-CycloproPvlethylV3-r4-C2-methyl-l,3-thiazol-4-vnphenyll-2,4,6(1H,3H,5H)-pyrimidinetnone. Cyclopropylethylamme hydrochloride (620 mg, 5 I mmoles) m chloroform (50 mL) was treated with dnsopropylethylamme (2 1 mL, 12 0 mmoles) followed by 4-(4-isocyanatophenyl)-2-methyl-l,3-thiazole (1 1 g, 5 1 mmoles) The mixture was stirred for 2 hours, malonyl dichlonde (583 uL, 6.0 mmoles) was added and the mixture heated at 63°C for 2 hours The mixture was washed with 1 molar hydrochloric acid and purified by flash chromatography (0-7.0% methanol m dichloromethane) to give the title compound (620mg, 33%) 1H NMR (400 MHz, CHLOROFORM-**) δ ppm 8 03 (d, J-8 59 Hz, 2 H), 7 39 (s. 1 H), 7 26 (d, J=8 84 Hz, 2 H), 4 01 - 4 10 (m, 2 H), 3 88 (s, 2 H), 2 81 (s, * H), 1 58 (q. 2 H), 0 67 - 0 ^8 (m, 1 H), 0 44 - 0 50 (m, 2H), 0 06-0.13 (m, 2 H) 113b) N-({3-r2-Cyclopropylethyl')-6-hydroxy-l-[4-(2-methyl-1.3-thiazol-4-vl)phenyll-2,4-dioxo-1.2,3.4-tetrahydro-5-pynmidmvl}carbonyl)glvcme A mixture of 1 -(2-cyclopropylethyl)-3-[4-(2-methyl-l,3-thiazol-4-yl)phenyl]-2,4,6(1H,3H,5jf/)-pyrimidmetnone (618 mg, 1 67 mmoles) and and dnsopropylethylamine (578 uL, 3 34 mmoles) in dichloromethane (50 mL) was treated with ethyl isocyanatoacetate (224 uL, 2 0 mmoles) and stirred overnight The mixture was washed with 1 molar hydrochloric acid (x2), dried and evaporated The residue was dissolved in ethanol (5 mL) and treated with 6 molar sodium hydroxide (2 0 mL) The mixture was stirred for 2 hour, acidified and extracted with ethyl acetate (x2), dried and evaporated Flash chromatography (dichloromethane to 3 5% methanol-0 1 % acetic acid) gave the title compound which was obtained as a solid from diethyl ether. (210 mg, 27%) 1H NMR (400 MHz, DMSO-d6 > § ppm 13 11 (br s, 1 H), 10.08 (br. s, 1 H), 7.97 - 8.05 (m, 3 H). 7 37 (d, J=6 82 Hz, 2 H). 4 14 (d, J=5 56 Hz, 2 H), 3 88 - 3 98 (m, 2 H), 2 74 (s, 3 H), 1 50 (q, J=7 07 Hz, 2 H), 0 65 - 0 75 (m, 1 H), 0 37 - 0 46 (m, 2 H), 0 03 (q, J=4.72 Hz, 2 H) Example 114 (Formula Removed) N- {r3-Cyclohexyl-6-hydroxy-2,4-dioxo-1 -(4-pipendinyl)-1,2,3,4-tetrahydro-5-pyrimidinyllcarbonyl} glycine 114a) Phenylmethyl 4-(l,3-dioxo-l,3-dihydro-2H-isoindol-2-vl)-1 -pipendmecarboxylate. A mixture of benzyl 4-hydroxy-1-piperidme carboxylate (2.0 g, 8 5 mmoles), phthalimide (2 5 g, 17 mmoles), triphenylphospbine (4 46 g, 17 mmoles) and dusopropyl azodicarboxylate (3 345 mL, 17 mmoles) were stirred together in tetrahydrofuran (60 mL) for 5 hours The mixture was evaporated onto silica gel and chromatographed (hexane to 60% ethyl acetate - hexane) The fractions afforded crystalline product on standing (1 5 g, 48%) 1H NMR (400 MHz, DM SO-d6) δ ppm 7 76-7 94 (m, 5 H), 7.37 -7 41 (m, 3 H), 7 30 - 7 37 (m, 1 H), 4 71 - 4 83 (m, 1 H), 4 18-4 29 (m, 1 H),4 14(d,J=13 64Hz, 2 H), 2 16(dd,2H), 1 73 (d,.J=10 36 Hi, 2 H), 1 18 (d,J=6 32 Hz, 2H) 114b) Phenylmethyl 4-amino-1 -pipendmecarboxylate A mixture of phenylmethyl 4-(l ,3-dioxo-l,3-dihydro-2/f-isoindol-2-yl)-l-piperidmecarbo\ylate (1 5 g, 4 11 mmoles) and 25% hydrazine hydrate (10.0 mL) in ethanol (20 mL) was heated under reflux for 30 minutes The mixture was evaporated, re-diluted with ethanol and re-evaporated to a solid. The solid was slurried m diethyl ether, collected, washed with diethyl ether and the filtrate evaporated to give the title compound as an oil (quant.) 1H NMR (400 MHz, CHLOROFORM-^ 8 ppm 7 25 - 7 45 (m, 5 H), 5 14 (s, 2 H), 4.89 - 5 07 (m, 1 H), 3 18 - 3.42 (m, 2 H), 2 76 - 2 95 (m, 2 H), 1 74 - 1 94 (m, 2 H), 1 51 - 1 68 (m, 2 H), 1 28 (d, J=6 06 Hz, 2 H) 114c) Phenvhflethyl 4-f3-cyclohexyl-2.4.6-trioxotetrahydro-1 f2H)-pynmidmyl)-1 -pipendmecarboxylate A mixture of phenylmethyl 4-ammo-l-pipendmecarboxylate (700 mg, 2 98 mmoles) and cyclohexyl isocyanate (457 uL, 3 6 mmoles) was stirred m chlorofonn (60 mL) for 2 hours Malonyl dichloride (350 uL, 3 6 mmoles) was added and the mixture was stirred at 50"C for 2 hours. The mixture was washed with 1 molar hydrochloric acid (x2) and evaporated onto silica gel. Flash chromatography (dichloromethane to 30% methanol m dichloromethane) gave the title compound (350 mg, 80%) 1H NMR (400 MHz, DMSO-c/6) δ ppm 7 24 - 7 47 (m, 5 H), 5 10 (s, 2 H), 4 61 - 4 78 (m, 1 H), 4 35 - 4 52 (m, 1 H\ 4 09 (d, .J=10 86 Hz. 2 H), 3 70 (s, 2 H). 2 85 (d, .J=26 02 Hz, 2 H), 2.20 - 2.33 (m, 2 H), 2 14 (dd, 1 H), 1 78 (d, 2 H), 1 58 (d, .J=11 12 Hz, 4 H), 1 00 - 1 34 (m, 5 H) 114d) N- {r3-Cyclohexyl-6-hydroxy-2,4-dioxo-1 -(4-pipendinyl)-1,2,3,4-tetrahydro-5-pyrimidinyncarbonvUglycine A mixture of phenylmethyl 4-(3-cydohexyl-2,4,6-trioxotetrahydro-l(2H)-pyrimidinyl)-l-piperidmecarboxylate (530 mg, 1 24 mmoles) and dnsopropylethylamme (536 uL, 3 1 mmoles) m chloroform (50 mL) was treated with ethyl isocyanatoacetate (225 uL, 2 0 mmoles) and stirred overnight The mixture was washed with 1 molar hydrochloric acid (x2), dned and evaporated. The residue was dissolved in isopropanol (30 mL), the solution flushed with argon and 10% palladium on charcoal catalyst (100 mg) added The mrxtuie was shaken in a hydrogen atmosphere at 50 psi for 2 hours The mixture was filtered, evaporated and treated with 1 molar sodium hydroxide solution overnight. Acidified and extracted into ethyl acetate Preparative HPLC (10 to 80% acetonitnle-water-0 1%TFA) gave the title compound (120 mg, 24%) 1HNMR(400 MHz, DMSO-(/6) δppm 13 17 (s, 1 H), 10 18 (s. 1 H), 8 74 (A,J=\ 1 12 Hz, 1 H), 8 32 - 8 40 (m, 1 H), 8 29 (s, 1 H), 4 95 (t, 7-12 6} Hz, 1 H), 4.63 ft, 7-12.63 Hz, 1 H), 4 15 (d, J=5 81 Hz, 2 H), 3.36 (d, J=12 13 Hz, 2 H), 3 02 (q, J=12 55 Hz, 2 H), 2 61 - 2 73 (m, 2 H), 2 20-231 (m, 2 H), 1.79 (d, .J=12.38 Hz, 4 H), 1 62 (>, 3 H i, 1 22 - 1 34 (m, 2 Hj. 1 10 (d J=16 42 Hz, 1 H) Example 115 (Formula Removed) N-({3-(2-Cyclopropylethyl)-l-r4-(2-furanyl)phenyn-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5- pynmidmyl} carbonyl )elvcme 115a) l-(2-Cyclopropylethyl)-3-['4-(2-furanyl)phenyll-2,4,6(1H,3H,5/J)-pyTimidinetnone Cyclopropylethylamine hydrochloride (693 mg, 5 67 mmoles) m chloroform (50 mL) was treated with dnsopropylethylamme (1.04 mL, 6 0 mmoles) followed by 2-(4-isocyanatophenyl) furan (1 05 g, 5 67 mmoles). The mixture was stirred for 2 hours, malonyl dichlonde (665 uL, 6.84 mmoles) was added and the mixture heated at 63°C for 2 hours The mixture was washed with 1 molar hydrochloric acid and purified by flash chromatography (0-3 5% methanol in dichloromethane) to give the title compound (330 mg, 17%; 1H NMR (400 MHz, DMSO-76> 5 ppm 7 75 (d, .7-8 59 Hz, 2 H), 7.59 - 7.63 (m, 1 H), 7 55 - 7.59 (m, 1 H), 7 27 (d, J=8 59 Hz. 2 H), 7 18 (dd, J=5 05, 3 54 Hz, 1 H), 3 88 (s, 2 H), 3 84 (t, 2 H), 1 44 (q, J=7 33 Hz, 2 Hj. 0 o3 - 0 76 (m, 1 H), 0 36 -0 44 (m, 2 H), 0.01 - 0 07 (m, 2 H) H5b) N-({3-f2-CycloDropylethyl)-l-r4-(2-ruranyl)phenyll-t>-hydroxy-2.4-dioxo-1.2,3.4-tetrahydro-5-pyrimidinvUcarbonyl)glvcme A mixture l-(2-cyclopropylethyi)-3~[4-(2-furanyl)phenyl]-2,4,6(l/f,3H,5H)-pynmidmetnone (330 mg, 0 976 mmoles) and and dnsopropylethylamine (337 uL, 1 95 mmoles) in dichloromethane (80 mL) was treated with ethyl isocyanatoacetate (131 uL, 1 17 mmoles) and stirred overnight. The mixture was washed with 1 molar hydrochloric acid (x2), dned and evaporated The residue was dissolved m ethanol (5 mL) and treated with 6 molar sodium hydroxide (2 0 mL) The mixture was stirred for 2 hour, acidified and extracted with ethyl acetate (x2), dried and evaporated Flash chromatography (dichloromethane to 3 5% methanol-0 1% acetic acid), material still impure, re-chromatographed (hexane-ethyl acetate) gave the title compound (30 mg, 7%) 1H NMR (400 MHz, DMSO-J6) δ ppm 13 10 (s, 1 H), 10.08 (br s , 1 H), 7 80 (s, 2 H), 7 78 (s, 1 H), 7 36 (d, .J=7 33 Hz, 2 H), 7.04 (d, .J=3 28 Hz, 1 H), 6 64 (dd, J=3 28, 1 77 Hz, 1 H), 4 14 (d, .J= 5 81 Hz, 2 H), 3 94 (t, 2 H), 1 50 (q, J=6 65 Hz, 2 H), 0 63 - 0 77 (m, I H), 0 36 - 0 46 (m, 2 H), -0 01 - 0 07 (m, 2 H) Example 116 (Formula Removed) N-{ri,3-Bis(l.l-dimethylpropyl)-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pynmidinyllcarbonyl \ glycine 116a) MN-Bisn, 1 -dimethylpropyDurea A mixture of carbonyldnmidazole (3 0 g, 18 5 mmoles) and f-amylamine (4.7 mL, 40 mmoles) m dimethylformamide (25 mL) was heated at 70°C for 3 hours The mixture was cooled and partitioned between ethyl acetate and 1 molar hydrochlonc acid. The aqueous was extracted with ethyl acetate and the combined extracts washed with 1 molar hydrochlonc acid, dned and evaporated to a solid (2 9 g. 78%) 1H NMR (400 MHz, DMSO-J6) δ ppm 5 37 (s, 2 H), 1.55 (q, J=7.33 Hz. 4 H), 1 13 (s, 12 H), 0 76 (t,.J=7 45 Hz, 6 H) 116b) L3-Bisd.l-dunethylpropylV2.4.6(1H.3H.5H)-pynmidinetnone V,7Y-bis(l,l-dimethylpropyDurea (1 6 g, 8.0 mmoles) in chloroform (60 mL) was treated with malonyl dichloride (935 uL, 9 6 mmoles) and heated at 70°C for 3 hours The mixture was washed with 1 molar hydrochloric acid (x2), dned and evaporated Flash chromatography (hexane - 50% ethyl acetate in hexane) gave the title compound (960 mg, 44%) 1H NMR (400 MHz, CHLOROFORM-*/) δ ppm 3 49 (s, 2 H), 2 04 (q, ,J=7 41 Hz, 4 H). 1 55 (N 12 H) 0 85 (t, J=7.45 Hz, 6 H) 116c) N- in .3-Bis(l. 1 -dimethylpropyl)-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pynmidinyl]carbonyl 1 glycine A mixture of l,3-bis(l,l-dimethylpropyl)-2.4,6(1H,3H,5H)-pyrimidinetrione (960 mg, 3 5 mmoles) and and diisopropylethylamme (121 mL, 7.0 mmoles) in dichloromethane (50 mL) was treated with ethyl isocyanatoacetate (482 uL, 4 3 mmoles) and stirred overnight The mixture was washed with 1 molar hydrochloric acid (\2), dried and evaporated The residue was dissolved in ethanol (10 mL) and treated with 6 molar sodium hydroxide (5.0 mL) The mixture was stirred for 72 hour, acidified and extracted with ethyl acetate (x2), dried and evaporated The residue was stored at -10°C overnight, crystallized. The solid was slurried in hexane, collected, washed with hexane to give the title compound (600 mg, 46%) 1H NMR (400 MHz, DMSO-d6) δ ppm 12 71 (br s, 1 H), 10 12 (t,.j=6 Oo Hz, 1 H), 4 08 (d, J=5 81 Hz, 2 H), 2 00 - 2.10 (m, 4 H), 1 54 (s, 12 H), 0 79 (m, 6 H) Example 117 (Formula Removed) N- lf3-Cyclohexyl-6-hydroxy-2.4-dioxo-1 -(3-prperidinyl)-1,2.3,4-tetrahydro-5-pynmidinyllcarbonyl \ glycine 117a) Phenylmethyl3-(3-Cyclohexyl-2,4.6-tnoxotetrahydro-l(2H)-pynmidmvl)-l-piperidinecarboxylate. A mixture of benzyl 3-aminopipendine-1 -carboxylate hydrochloride (1 51 g, 5.57 mmoles), diisopropylethylamme (965 uL, 5 57 mmoles) and cyclohexyhsocyanate (708 uL, 5.57 mmoles) were stirred together m dichloromethane (60 mL) overnight The mixture was washed with 1 molar hydrochloric acid (x2) and the solution dried Malony 1 dichloride (650 uL, 6 68 mmoles) was added and the mixture was heated under gentle reflux for 4 hours The mixture was washed with 1 molar hydrochloric acid (x2) and the solution dned and evaporated The title compound was obtained as a solid from diethyl ether (1 0 g, 42%) 1H NMR (400 MHz, DMSO-d6) δ ppm 7 24 - 7.47 (m, 5 H), 5 09 (s, 2 H), 4 35-4 58 (m, 2 H), 3 98 (d, 2 H), 3 68 (d, J=A 29 Hz, 2 H), 3 35 - 3 60 (m, 1 H), 2.32 (q, 1 H), 2 07 - 2 21 (m, 2 H), 1 66 - 1 87 (m. 5 H), 153-1 65 (m, 3 H), 1.36 - 1.50 (m, 1 H), 1.26 (q, J=J3 05 Hz, 2 H), 1 03 - 1 15 (m, 1 H; 117b) Example 118 (Formula Removed) Phenylmethy{3-r3-Cyclohexyl-5-({r2-(ethyloxy)-2-oxoethyllammofcarboryyl)-6-hydroxy-2.4-dioxo-3,4-dihydro-1 (2ffl-pynmidinyll -1 -pipendinecarboxylate A mixture of phenylmethyl 3-(3-cyclohexyl-2,4,6-trioxotetrahydro-l(27^-pynmidmyl)-l-pipendinecarboxylate (1.0 g, 3 5 mmole) and and diisopropylethylamine (1 2 mL, 7 0 mmoles) in dichloromethane (60 mL) was treated with ethyl isocyanatoacetate (450 uL. 4 0 mmoles) and stirred overnight. The mixture was washed with 1 molar hydrochloric acid (x2), dried and evaporated to a glassy solid (1 3 g, 67%) lHNMR(400MHz,DMSO- N- {[3-CyeIohffxyl-6-hydroxy-2,4-dioxo-1 -(1 - {[( phenylmethyl )oxy]carbonyl 1-3 -pipendinyl) 1.2.3.4-tetrahydro-5-pyrimidinvricarbonyl} glycine 117c) N-{[3-Cyclohexyl-6-hydroxy-2.4-dioxo-l-(3-pipendinyl)-1.2,3.4-tetrahydro-5-pynnudinyllcarbonyl) glycine hydrobromide. Phenylmethyl 3-[3-cyelohexyl-5-( f[2-(ethyloxy)-2-oxoethyl]amino}carbonyl)-6-hydroxy-2,4-dioxo-3,4-dihydro-1 (2H)-pynmidinylJ-1 -pipendinecarboxylate (1.2 g, 2.15 mmoles) was stnred m a mixture of acetic acid (30 mL) and 48% hydrobromic acid (5.0 mL) for 40 hours - reaction incomplete The mixture was then heated at 60°C for 2 hours, diluted with water and extracted with ethyl acetate (x5) The combined extracts were dried and evaporated, and recrystallized from diethyl ether hexane to give the title compound (160 mg, 20%) 1H NMR (400 MHz, DMSO-^6j 8 ppm 12 84 Ibr s , 1 H), 10 11 (s, 1 H), 8.86 (s, 1 H), 5.12 (s, 1 H), 4.63 (t, J=]2 00 Hz, 1 H), 4 09 (s, 2 H), 3 66 (t, J=\ 1 37 Hz, 1 H), 3 28(d,J=10.61Hz,2H),2.77(t,J=ll 12 Hz, 1 H), 2 36 (dd, J=\2 38, 3 54 Hz, 1 H), 2 22 - 2 32 (m, 2 H), 1 89 (d, .J=12.63 Hz, 1 H), 1.69 - 1 81 (m, 4 H), I 55 - 1 67 (m, 4 H), 1 27 (q, J=12 88 Hz, 2 H), 1 11 (q, J=12 97 Hz, 1 H) Phenylmethyl 3-[3-cyclohexyI-5-( {[2-(ethyloxy)-2-oxoethyl]ammo j carbonyl)-6-hydroxy-2,4-dioxo-3,4-dihydro-l(2i?)-pyrimidinyl]-l-pipendinecarboxylate (100 mg, 0 18 mmoles) was dissolved in ethanol (3.0 mL) and treated with 6 molar sodium hydroxide (1 5 mL) The mixture was stirred for 2 hours, acidified and extracted with ethyl acetate (x2) The combined extracts were washed with 1 molar hydrochloric acid, dried and evaporated to a foam (80 mg, 84%) 1H NMR (400 MHz, DMSO-J6) δ ppm 13 11 (s, 1 H), 10 17 (s, 1 H), 7 30 - 7 40 (m, 5 H), 5 10(s,2 H), 4 57 - 4.69 (m, 2 H), 4 13 (d, .J=5.81 Hz, 2 H), 3.95 - 4 05 (m, 2 H), 3 64 (s, 1 H), 3 37 (s, 1 H), 2 73 (s, 1 H), 2.36 - 2.48 (m, 1 H), 2 25 (q,7-=l 1 62 Hz, 2 H), 1.70 - 1 82 (m, 4 H), 1 62 (d, .J=11 37 Hz, 3 H), 1 38 - 1 50 (m, 1 H), 121-1 33 (m, 2 H), 1.06 - 1 18 (m, 1 H) Example 119 (Formula Removed) N- f[l-(l-Acetvl-3-pipendinyl)-3-Cyclohexyl-6-hydroxy-2,4-dioxo-1,2,3.4-tetrahydro-5- pynmidinyllcarbonyl I glycine A solution of N-{[3-cyclohexyl-6-hydroxy-2,4-dioxo-L(3-pipendmyl)-1,2,3,4-tetrahydro-5-pynmidmyl]carbonyl}glycine (500 mg. 1 26 mmoles) m acetic acid (5 0 mL) and acetic anhydride (5.0 mL) was heated at 130°C for 2 hours The mixture was cooled, diluted with ethyl acetate and washed with 1 molar hydrochloric acid (x3), dried and evaporated Flash chromatography (dichloromethane to 4% methanol-0.1% acetic acid m dichloromethane) and recrystallization from ethanol - water gave the title compound (170 mg, 31%) 1H NMR (400 MHz, DMSO- Example 120 (Formula Removed) N-[(1 -Cyclohexyl-3-{[4-fluoro-2-ftnfluoromethyl)phenyl1methyl \ -6-hydroxy-2.4-dioxo-1,2,3,4- tetrahydro-5-pyiimidinyl)carbonyllglvcine A mixture of ethyl N-[(l-cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycmate (340 mg, 1 0 mmoles), pulv potassium carbonate (750 mg, 5.35 mmoles) and 4-fluoro-2-trifluoromethylbenzyl bromide (455 mg, 1 77 mmoles) m dimethylacetamide (6 mL) was vigorously stirred at 100°C for 3 hours The mixture was poured into 1 molar hydrochloric acid and extracted with ethyl acetate (x2). The combined organic solutions were washed with 1 molar hydrochloric acid and evaporated The residue was purified by flash chromatography (10-50% ethyl acetate m hexane), the required fractions evaporated, dissolved in ethanol (5 mL) and 1 molar sodium hydroxide solution (3 0 mL) added The mixture was shrred overnight, acidified and extracted with ethyl acetate (x2), the combined extracts washed with 1 molar hydrochloric acid, dried and evaporated Recrystallization from hexane gave the title compound (184 mg, 38%) 1H NMR (400 MHz, DMSO-d6) δ ppm 13 10 (br s., 1 H), 10 11 (br s , 1 H), 7 67 (dd, J=9 09, 2.78 Hz, 1 H), 7 45 (ddd, J=8 40, 2 65 Hz, 1 H), 7 29 (dd, J=8 59, 5 31 Hz, 1 H), 5 13 (s, 2 H), 4 64 (t,J=12.00 Hz, 1 H), 4 13 (d, /-5 81 Hz. 2 H), 2 24 (q, 2 H), 1 78 (d, J=12 63Hz, 2H), 1.53- 1 73 (m, 3 H), 1 28 (q, 7-12 72 Hz, 2 H), 1 10 (q, J=12 63 Hz, 1 HI Example 121 (Formula Removed) N-({3-[(2-Bromophenynmethyll-l-Cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5- pynmidinyl 1 c arbonyl) glycine A mixture of ethyl N-[(l-cyclohexyl-6-hydroxy 2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycinate (340 mg, 1 0 mmoles),pulv potassium carbonate (750 mg, 5 35 mmoles) and 2-bromobenzyl bromide (480 mg, 1 92 mmoles) in dimethylacetamide (6 mL) was vigorously stirred at 100°C for 3 hours The mixture was poured into 1 molar hydrochloric acid and extracted with ethyl acetate (x2) The combined organic solutions were washed with 1 molar hydrochloric acid and evaporated. The residue was purified by flash chromatography (10-50% ethyl acetate in hexane), the required fractions evaporated, dissolved in ethanol (5 mL) and 1 molar sodium hydroxide solution (3 0 mL) added The mixture was stirred overnight, acidified and extracted with ethyl acetate (x2), the combined extracts washed with 1 molar hydrochloric acid, dned and evaporated. Recrystallization from ethanol-water gave the title compound (150 mg, 38%). 1HNMR (400 MHz, DMSO-d6) δppm 13 11 (br s , I H), 10 12 (br s , 1 H), 7 65 (dd, J=7.96, 1 14 Hz, 1 H), 7.32 (ddd, J=7 52, 1.14 Hz, 1 H), 7 22 (ddd, J=7.64, 1 64 Hz, 1 H), 7 03 (dd, J=7 58, 1 26 Hz, 1 H), 5 00 (s, 2 H), 4 65 (t, J-=12 13 Hz, 1 H), 4 13 (d, J=5 81 Hz, 2 H), 2 25 (q, 2 H), 1 79 (d, J=12 88 Hz, 2 H), 1.54-1 72 (m, 3 H), 1 28 (q, .J=13 14 Hz, 2 H), 1 10 (q, ,J=12 38 Hz, 1H) Example 122 (Formula Removed) N-({l-Cyclphexyl-3-f(2,6-dichlorophenynmethyll-6-hydroxy-2,4-dioxo-1.2,3,4-tetrahydro-5- pyrimidinyl}earbonyl)grycine A mixture of ethyl N-[(l-cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-terrahydro-5-pyrimidinyl)carbonyl]glycmate (340 mg, 1 0 mmoles), pulv potassium carbonate (750 mg, 5 35 mmoles) and 2,6-dichlorobenzyl bromide (440 mg, 2 0 mmoles) m dimethylacetamide (6 mL) was vigorously stirred at 100°C for 3 hours The mixture was poured into 1 molar hydrochloric acid and extracted with ethyl acetate (x2) The combined organic solutions were washed with 1 molar hydrochloric acid and evaporated The residue was purified by flash chromatography (10-50% ethyl acetate in hexane), the required fractions evaporated, dissolved m ethanol (5 mL) and 1 molar sodium hydroxide solution (3.0 mL) added The mixture was stirred overnight, acidified and extracted with ethyl acetate (x2), the combined extracts washed with 1 molar hydrochloric acid, dned and evaporated. Recrystallization from ethanol-water gave the title compound (150 mg, 32%) 1H NMR (400 MHz, DMSO-J6) δ ppm 13 07 (br s , 1 H), 9 98 (br s , 1 H), 7 43 (dd, 2 H), 7 30(dd, 1 H), 5 26(s, 2 H), 4 60 (t, J= 12 00 Hz, 1 H), 2 14-2 31 (m,2H), 1 77 (d, J=U 88 Hz, 2 H), 1 47 - 1.66 (m, 3 H), 1 27 (q, 2 H), 1 10 (q, 1 H) Example 123 (Formula Removed) N-1[_(3- {[2-Bromo-5-(methyloxy)phenyl]methyl} -1 -Cyclohexyl-6-hydroxy-2.4-dioxo-1.2.3.4-tetrahydro-5-pynmidinyl)carbonyl]glveine A mixture of ethyl N-[(l-cyclohexyl-6-hydro\y-2,4-dioxo-l,2,3.4-tetrahydro-5-pynmidmyl)carbonyl]glycinate (340 mg, 1 0 mmoles), puh potassium carbonate (750 mg, 5 35 mmoles) and 2-bromo~5-methoxybenzyl bromide (560 mg, 2 0 mmoles) in dimethylacetamide (6 mL) was vigorously stirred at 100°C for 3 hours The mixture was poured into 1 molar hydrochloric acid and extracted with ethyl acetate (x2) The combined organic solutions were washed with 1 molar hydrochloric acid and evaporated. The residue was purified by flash chromatography (10-50% ethyl acetate in hexane), the required fractions evaporated, dissolved in ethanol (5 mL) and 1 molar sodium hydroxide solution (3 0 mL) added The mixture was stirred overnight, acidified and extracted with ethyl acetate (x2), the combined extracts washed with 1 molar hydrochloric acid, dried and evaporated Recrystallizatkm from acetic acid-water gave the title compound (150 mg, 29%) 1H NMR (400 MHz, DMSO-d6) 6 ppm 13 04 (br s , 1 H), 10 12 (br s., 1 H), 7 55 (d, J=8 84 Hz, 1 H), 6 84 (dd, J=8 84, 3 03 Hz. 1 H), 6 50 (d, J=l 78 Hz, I H), 4 94 (s, 2 H), 4 65 (t, J=l 1 75 Hz, 1 H), 4.13 (d. > 5 81 Hz, 2 H), 3 69 (s, 1 H), 2 25 (q, 2 H), 1 79 (d,J=13 14 Hz, 2 H), 1 54- 1 74 (m, 3 H), 1 28 (q,.J=12 72 Hz, 2 H), 1 10 (q, 7-12 88 Hz, 1 H) Example 124 (Formula Removed) N-{(3- {[2.4-Bisftnfluoromethyl)phenyllmethyl} -1 -cyelohexyl-6-hydroxy-2,4-dioxo-1,2,3.4-tetrahydro-5-pynmidmyl)carbonyllglycine A mixture of ethyl N-[(l-cyclohexyl-6-hydroxy-2,4-dioxo-l ,2,3,4-tetrahydro-5-pynmidinyl)carbonyl]glycmate (340 mg, 1 0 mmoles), puh potassium carbonate (750 mg, 5 35 mmoles) and 2,4-bis(tnfluoromethyl)benzyl bromide (375 uL, 2 0 mmoles) in dimethylacetamide (6 mL) was vigorously stirred at 100°C for 3 hours The mixture was poured into 1 molar hydrochloric acid and extracted with ethyl acetate (x2) The combined organic solutions were washed with 1 molar hydrochloric acid and evaporated. The residue was purified by flash chromatography (10-50% ethyl acetate in hexane), the required fractions evaporated, dissolved in ethanol (5 mL) and 1 molar sodium hydroxide solution (3 0 mL) added The mixture was stirred overnight, acidified and extracted with ethyl acetate (x2). the combined extracts washed with 1 molar hydrochloric acid, dried and evaporated Recrystalhzation from acetic acid-water gave the title compound (180 mg, 34%). 1H NMR (400 MHz, DMSO-d6) δ ppm 13 11 (br s , 1 H), 8 06 (s, 1 H), 7 98 (d, J=8.59 Hz, 1 H), 7 53 (d, J=8 34 Hz, 1 H), 5.23 (s, 2 H), 4 64 (t, .J=12 00 Hz, ] H), 4 13 (d, J=5.56 Hz, 2 H), 2.24 (q, 2 H), 1 78 (d, J=U 63 Hz, 2 H), 1.52 - 1 73 (m, 3 H), 1 28 (q, J=13.05Hz, 2H), 1 10 (q, 1 H) Example 125 (Formula Removed) N-[{3-rr2-Bromo-5-fluorophenyl)methyll-l-Cyclohexyl-6-hydroxy-2,4-dioxo-1.2.3,4-tetrahydro-5-pynmidinyl} carbonylOglvcine A mixture of ethyl N-f(l-cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-terrahydro-5-pyrimidinyl)carbonyl]glycmate (340 mg, 1 0 mmoles), pulv potassium carbonate (750 mg, 5 35 mmoles) and 2-bromo-5-fluorobenzyl bromide (375 uL, 2 0 mmoles) m dimethylacetamide (6 mL) was vigorously stirred at 100°C for 3 hours The mixture was poured into 1 molar hydrochloric acid and extracted with ethyl acetate (x2) The combined organic solutions were washed with 1 molar hydrochloric acid and evaporated The residue was purified by flash chromatography (10-50% ethyl acetate m hexane), the required fractions evaporated, dissolved in ethanol (5 mL) and 1 molar sodium hydroxide solution (3.0 mL) added The mixture was stirred overnight, acidified and extracted with ethyl acetate (x2), the combined extracts washed with 1 molar hydrochloric acid, dried and evaporated. Recrystallization from acetic acid-water gave the title compound (160 mg, 31%) 1H NMR (400 MHz, DMSO-d6) δ ppm 13 10 (br. s , 1 H). 10 10 (br s , 1 H), 7 69 (dd, J-8.59, 5.31 Hz, 1 H), 7.11 (ddd, J=8 53, 3 16 Hz, 1 H), 7 05 (dd, J=9 60, 2 78 Hz, 1 H), 4 95 (s, 2 H), 4 63 (t, .J=12.38 Hz, 1 H), 4 13 (d, J=5 81 Hz, 2 H), 2 24 (q, 2 H), 1.7y (d, J=13 14 Hz, 2 H), 1.52-1 74 (m, J=27 54, 1162Hz,3H), 1.28 (q, J=12 88 Hz, 2 H), 1 10 (q, J=12.97 Hz. 1 H). Example 126 (Formula Removed) N-[(3- {[2-Bromo-4-( 1,1 -dimethylethyl)phenyllmethyl} -1 -Cyclohexyl-6-hydroxy-2.4-dioxo-1.2,3,4-tetrahydro-5-Dynmidmvl)carbonynglvcine A mixture of ethyl N-[(l-cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pynmidinyl)carbonyl]glycinate (340 mg, 1 0 mmoles),pulv potassium carbonate (740 mg, 5 35 mmoles) and 2-bromo-l-(bromomethyl)-4-(l,l-dimethylethyl)berLzene (612 mg, 2.0 mmoles) in dimethylformamide (5 mL) was vigorously stirred at 100°C for 3 hours The mixture was poured into 1 molar hydrochloric acid and extracted with ethyl acetate (x2) The combined organic solutions were washed with 1 molar hydrochloric acid and evaporated The residue was purified by flash chromatography (10-50% ethyl acetate in hexane), the required fractions evaporated, dissolved in ethanol (5 mL) and 1 molar sodium hydroxide solution (1.0 mL) and 6 molar sodium hydroxide (1.0 mL) added. The mixture was stirred overnight, acidified and extracted with ethyl acetate (x2), the combined extracts washed with 1 molar hydrochloric acid, dried and evaporated. Preparative HPLC (50-90% acetonitnle-water-0 1% TFA) gave the title compound (40 mg, 7 5%) 1HNMR(400 MHz, DMSO-d6) δ ppm 13 17 (br s , 1 H), 10 14 (br s , 1 H), 7 59 (d, J=1 52 Hz, 1 H), 7.33 (dd, J=8.08, 1.52 Hz, 1 H), 6 92 (d, J=8 08 Hz, 1 H), 4 96 (s, 2 H), 4 65 (t, .J=11 75 Hz, 1 H),4.13(d,J=5 56Hz, 2H), 2 25(q,J=ll 54 Hz, 2 H), 1 79 (d, J=12 13 Hz, 2 H), 1.53- 1 73 (m, 3 H), 1 20 - 1 38 (m, 11 H), 1 11 (q, 1 H) Example 127 (Formula Removed) N-({l-Cyclohexyl-6-hydroxy-3-[(2-methylphenyl)methyn-2,4-dioxo-l,2,3,4-tetrahydro-5- pynmidinyl}carbonyl)glycine A mixture of ethyl N-f(l-cyclohexyl-6-hydroxy-2,4-dioxo-l,2.3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycinate (340 mg, 1 0 mmoles), pub, potassium carbonate (740 mg, 5 35 mmoles) and 2-methylbenzene (268 uL, 2 0 mmoles) in dimethylformamide (5 mL) was vigorously stirred at 100°C for 3 hours. The mixture was poured into 1 molar hydrochloric acid and extracted with ethyl acetate (x2). The combined organic solutions were washed with 1 molar hydrochlonc acid and evaporated. The residue was purified by flash chromatography (10-50% ethyl acetate in hexane), the required fractions evaporated, dissolved m ethanol (5 mL) and 1 molar sodium hydroxide solution (3 0 mL) added The mixture was stirred overnight, acidified and extracted with ethyl acetate (x2), the combined extracts washed with 1 molar hydrochloric acid, dned and evaporated. Preparative HPLC (20-90% acetonitnle-water-0 1% TFA) gave the title compound (12 mg, 3.0%) 1H NMR (400 MHz, DMSO-d6) δ ppm 13 11 (br s , I H), 10 15 (br s 1H), 7 00-7 29 (m, 3 H), 6.89 (d, J=6 82 Hz, 1 H), 4 96 (s, 2H),4 65 (t,.J=12 25 Hz, 1 H), 4 13 (d, J=5 56 Hz, 2H), 2.35 (s, 3 H), 2 26 (q, 2 H), 1 78 (d, J=12 13 Hz, 2 H), 1 51 - 1.72 (m, 3 H), 1 28(q,2H), 1 10 (q, 1 H) Example 128 (Formula Removed) N-{ri-Cyclohexyl-3-(l.l-dimethylpropyl)-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5- pynmidinyllcarbonyl} glycine 128a) l-Cycloh.exyl-3-(l.l-dimethylpropyls)-2.4,6(1H.3H.5H)-pyrimidmetrione A mixture of t-amylamme (118 mL, 10 mmoles) and cyclohexyl isocyanate (1 28 mL. 10 mmoles) in chloroform (50 mL) was stirred overnight Malonyl dichlonde (116 mL, 12 mmoles) was added and the mixture was heated at 50°C for 3 hours The mixture was evaporated and flash chromatographed (ethyl acetate 10-50% in hexane) to give the title compound (1.9 g, 68%) 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 4.54 (tt, .J=12 25, 3 66 Hz, 1 H), 3 56 (s, 2 H), 2 23 (ddd, J=24 88, 12 51,3 54Hz,2H),2.06(q,J=7 58Hz, 2H), 1 77 - 1 91 (m, 2 H), 1 52 1 72(m,9H), 1 35 (qt, .J=13 09,3.28, 3.16 Hz, 2 H), 1 22 (qt, .J=12 87, 12 66.3 28 Hz, 1 H), 0 83 (t, .J=7 45 Hz, 3 H) 128b) N-{[1-Cyclohexyl-3-(l.l-dimethybropyl)-6-hydroxy-2,4-dioxo-1.2,3.4-tetrahydro-5-pyrimidinyllcarbonynglycine A mixture of 1 -cyclohexyl-3-(l .1-dimethylpropyl)-2,4,6(1H,3H,5H)-pyrimidinetnone (1 9 g, 6 8 mmoles), dnsopropylethylamme (2 35 mL, 13 6 mmoles) and ethyl isocyanatoacetate (915 uL, 8 16 mmoles) in dichloromethane (60 mL) was stirred for 72 hours The mixture was washed with 1 molar hydrochlonc acid (x2) and evaporated The residue was dissolved m ethanol (10 mL). treated with 6 molar sodium hydroxide (5 mL) and stirred overnight. The mixture was diluted with ethyl acetate, washed with 1 molar hydrochlonc acid (x2), dned and evaporated. The residue was crystallized from a small amount of acetic acid to give the title compound (960 mg, 37%) 1H NMR (400 MHz, DMSO- Example 129 (Formula Removed) N- {1,3-Bis(2,6-dichlorophenyl )-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pynmidinyllcarbonyl} glycine 129a) N,N-Bis(2.6-dichlorophenyl)urea 2,6 dichloroanilme (3 47 g, 21 4 mmoles) and carbonyldiimidazole (3 24 g, 20 mmoles) were heated together m dimethylformamide (75 mL) for 4 hours. The mixture was cooled and partitioned between ethyl acetate and 1 molar hydrochlonc acid, which produced a solid The solid was collected washed with ethyl acetate, hexane and dned to give the title compound (940 mg, 27%) 1H NMR (400 MHz, DMSO-d6) δ ppm 8 44 (s, 2 H), 7.52 (d, J=8.08 Hz, 4 H). 7 28 - 7 35 (m, 2 H) 129b) 1.3-B^(2.6-dichlorophenyl)-2.4,6(1H,3H,5H)-pynmidinetnone A mixture of N,N-bis(2,6-dichlorophenyl)urea (850 mg, 2 43 mmoles) and malonyl dichlonde (240 uL, 2 47 mmoles) in chloroform (500 mL) was heated under reflux for 3 hours Another aliquot of malonyl dichlonde (240 uL, 2 47 mmoles) was added and heating continued for a further 2 hours The mixture was filtered, evaporated and punfied by flash chromatography (dichloromethane to 2% methanol in dichloromethane) to give the title compound (200 mg, 20%) 1H NMR (400 MHz, DMSO-d6) δ ppm 7.66 (d, J=8.08 Hz, 4 H), 7 53 (t, J=8 08 Hz, 2 H), 4 93 (br s 2 H) 129c) N-(ri.3-Bisf2.6-dichloroDhenyl)-6-hydroxy-2.4-dioxo-l,2.3,4-terrahydro-5-pyrimidmvl]carbonyU glycine. A mixture of 1,3-bis(2,6-dichlorophenyl)-2,4,6(1H,3H,5H)-pyrimidmetnone (200 mg, 0.478 mmoles), diisopropylethylamme (210 uL, 0 96 mmoles) and ethyl isocyanatoacetate (126 uL, 0 574 mmoles) in dichloromethane (50 mL) was stirred overnight. Reaction was very slow, therefore additional diisopropylethylamme (1 0 mL, 3 4 mmoles) and ethyl isocyanatoacetate (500 uL, 2.6 mmoles) was added and the mixture was heated batchwise (3 x 20 mL) in a microwave reactor at 120°C for 20 minutes The combined reaction mixtures was washed with 1 molar hydrochlonc acid (x2) and evaporated The residue was dissolved in ethanol (5 mL), treated with 6 molar sodium hydroxide (5 mL) and stirred for 1 hour The mixture was diluted with ethyl acetate, washed with 1 molar hydrochlonc acid (x2), dried and evaporated. The residue was crystallized from a small amount of acetic acid to give the title compound (138 mg, 55%). 1H NMR (400 MHz, DMSO-d6) δ ppm 13 25 (br s , 1 H), 10 11 (t, .J=5.68 Hz, 1 H), 7.67 -7.76 (m, 4 H), 7.59 (dd, .J=8.84, 7.58 Hz, 2 R), 4 18 (d, J=5 56 Hz, 2 H) Biological Background: The following references set out information about the target enzymes, HIF prolyl hydroxylases, and methods and materials for measuring inhibition of same by small molecules. M. Hirsila, P. Koivunen, V. Giinzler, K I Kivmkko, and J Myllyharju "Characterization of the Human Prolyl 4-Hydroxylases That Modify the Hypoxia-inducible Factoi" J. Biol Chem , 2003, 278, 30772-30780 C. Willam, L. G. Nicholls, P J Ratcliffe, C W Pugh, P H Maxwell "The prolyl hydroxylase enzymes that act as oxygen sensors regulating destruction of hypoxia-inducible factor a" Advan. Enzyme ReguL, 2004, 44, 75-92 M. S Wiesener, J. S. Jurgensen, C Rosenberger. C K. Scholze, J H Horstrup, C Wamecke, S Mandriota, 1 Bechmann, U A Frci, C W Pugh, P f Ratchffc, S. Bachmann, P H Maxwell, and K.-U. Eckardt "Widespread hypoxia-inducible expression of HlF-2u m distinct cell populations of different organs" FASEB J, 2003, 17 271-273 S. J. Klaus, C J Molmeaux, T B Neff, V Guenzler-Pukall, J Lansetmo Parobok, I W Seeley, R. C Stephenson "Use of hypoxia-inducible factor a (HIFa) stabilizers for enhancing erythropoiesis" PCT Int. Appl (2004), WO 2004108121 Al C Wamecke, Z Zaborowska, J Kurreck. V A Erdmann, U r-rei, M Wiesener, and K -U Eckardt "Differentiating the functional role of hypoxia-inducible factor (HlF)-la and HIF-2a (EPAS 1) by the use of RNA interference erythropoietin is a HlF-2a target gene in Hep3B and Kelly cells" FASEB J., 2004, 75, 1462-1464 For the expression oj EGLN3 see. R. K Bruick and S. L McKmght "A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF" Science, 2001, 294, 1337-1340 For the expression of HIFla-CODD see a) P Jaakkola, D. R. Mole, Y -M Tian, M 1 Wilson, J Gielbert. S J Gaskell, A. von Kriegsheim, H. F. Hebestreit, M Mukherji, C / Schofield, P H Maxwell, C. W Pugh, P, J Ratcliffe "Targeting of F£IF-a to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation" Science, 2001, 292, 468-472. b) M Ivan, K. Kondo, H. Yang, W Kim, J Valiando, M Ohh, 4 Salic, J M Asara, W. S Lane, W G. Kaelin Jr. "HIFa Targeted for VHL-Mediated Destruction by Proline Hydroxylation. Implications for 02 Sensing'" Science, 2001, 292, 464-468 For the expression of VHL, elongin b and elongin c see A. Pause, S Lee, R A. Worrell, D. Y T Chen, W H. Burgess, W M. Lmehan, R D Klausner "The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins" Proc Natl Acad Sci USA, 1997, 94, 2156-2161 Biological Assay(s) EGLN3 Assay Materials: His-MBP-EGLN3 (6HisMBPAttBlEGLN3(]-239>) was expressed in E Colt and purified from an amylase affinity column Biotin-VBC [6HisSumoCysVHL(2-213), 6HisSumoElonginB(l-l 18), and 6HisSumoElonginC(l-l 12)] and His-GBl-HIF2a-CODD (6HisGBltevHIF2A(467-572)) were expressed from E Coh Method: Cy5-labelled HIF2a CODD, and a biotm-labeled VBC complex were used to determine EGLN3 inhibition EGLN3 hydroxylation of the Cy5CODD substrate results m its recognition by the biotm-VBC. Addition of a Europium/streptavidm (Eu/SA) chelate results in proximity of Eu to Cy5 in the product, allowing for detection by energy transfer A ratio of Cy5 to Eu emission (LANCE Ratio) is the ultimate readout, as this normalized parameter has significantly less vanance than the Cy5 emission alone Then 50nL of inhibitors in DMSO (or DMSO controls) were stamped into a 384-well low volume Corning NBS plate, followed by addition of 2 5 uL of enzyme [50 ml. buffer (50 mM HEPES/50 mM KC1) + 1 mL of a 10 mg/mL BSA in buffer + 6 25 uL of a lOmg/mL FeCl; solution in water + 100 uL of a 200 mM solution of ascorbic acid m water + 15 63 uL EGLN3] or control [50 mL buffer + 1 mL of a 10 mg/mL BSA in buffer -+ 6 25 uL of a lOmg/mL FeCL solution in water + 100 uL of a 200 mM solution of ascorbic acid in water] Following a 3 minutes incubation, 2.5 uL of substrate [50mL Buffer + 68 6 u.L biohn-VBC + 70 4 uJL Eu (at 710 u.g/mL stock) + 91.6 uJL Cy5CODD + 50 uL of a 20 mM solution of 2-oxoglutane acid m water + 0 3mM CHAPS] was added and incubated for 30 minutes The plate was loaded into a PerkinElmer Viewlux for imaging For dose response experiments, normalized data were fit by ABASE/XC50 using the equation y = a + (b-a)/(l+(10^/x10^c)^d), where a is the minimum % activity, b is the maximum % activity, c is the plC50, and d is the Hill slope All exemplified compounds herein (Examples 1 to 129) have demonstrated in vitro EGLN3 inhibitory activity in this assay and have IC50's in the range of 0 8 nanomolar to 20 micromolar This range represents the data accumulated as of the time of filing this application Later testing may show variations in IC5o data due to variations m reagents, conditions and variations m the method(s) used from those given herein above. Thus, these values are to be viewed as illustrative rather than absolute Measure Epo protein produced by Hep3B cell line using ELISA method. Hep3B cells obtained from the American Type Culture Collection (ATCC) are seeded at 2x10^4 cells/well in Dulbecco's Modified Eagle Medium (DMEM) + 10% FBS m 96-well plates Cells are incubated at 37degC/5% CO2/90% humidity (standard cell culture incubation conditions) After overnight adherence, medium is removed and replaced with DMEM without serum containing test compound or DMSO negative control Following 48 hours incubation, cell culture medium is collected and assayed by ELISA to quantitate Epo protein Of the exemplified compounds tested to date all, except Examples 8, 9, 31, 35, 39, 88, 91, 93, and 94, have demonstrated EC5o's in the Hep3B ELISA assay in the range of 0 4 micromolar to 100 micromolar using the reagents and under the conditions outlined herein above. Examples 8, 9, 31, 35, 39, 88, 91, 93, and 94, have demonstrated EC50's in the Hep3B ELISA assay of greater than 100 micromolar, the maximum concentration tested This range represents the data accumulated as of the time of the filing of this application Later testing may show variations in EC50 data due to variations in reagents, conditions and variations in the method(s) used from those given herein above Thus, these values are to be viewed as illustrative rather than absolute These compound are believed to be useful m therapy as defined above and to not have unacceptable or untoward effects when used m compliance with a permited therapeutic regime. The foregoing examples and assay have been set forth to illustrate the invention, not limit it. What is reserved to the inventors is to be determined by reference to the claims. We Claims :- 1. A compound according to formula (I): (Formula Removed) wherein: R1 and R4 are each independently selected from the group consisting of hydrogen, -NR5R6, C1-C10alkyl, C2-C10alkenyl, C2-C10alkynyl, C3-C8cyclcaikyl,C3-C8cycloalkyl-C1-C10alkyI, C5-C8cycloalkenyl, C5-C8cycloalkenyl-C1-C10alkyl, C3-C8heterocycloalkyl, C3-C8heterocycloalkyl- C1-C10alkyl, aryl, aryl-C1-C10alkyl, heteroaryl and heteroaryl-C1-C10alkyl; R2 is -NR7R8 or -OR9; R3 is H or C1-C4alkyl; where R5 and R6are each independently selected from the group consisting of hydrogen, C1-C10alkyl, C5-C8cycloalkyl, C3~C8cycloalkyl-C1-C10alkyl, C3-C8heterocyeloalkyl, C3-C8heterocycloalkyl-C1-C10alkyl. aryl, aryl-C1-C10alkyl, heteroaryl, heteroaryl- d.doalkyl, -C(O)C1-C4alkyl, -C(O)C3-C6cycloalkyl, -C(O)C3-C6heterocycloalkyl, -C(O)aryl, -C(O)heteroaryl and -S(O)2C1-C4alkyl, or, when R5 and R6 are attached to the same nitrogen, R5 and R6 taken together with the nitrogen to which they are attached form a 5- or 6- or 7-membered saturated ring optionally containing one other heteroatom selected from oxygen, nitrogen and sulphur, R7 and R8 are each independently selected from the group consisting of hydrogen, C1-C10alkyl, C2-C10alkenyl, C2-C10alkynyl, C3-C8cycloalkyl, C3-C8heterocycloalkyl, aryl and heteroaryl, and R9 is H or a cation, or CVC10alkyl which is unsubstituted or substituted with one or more substituents independently selected from the group consisting of C3-C6cycioalkyl, heterocycloalkyl, aryl and heteroaryl; X is O or S; and Y is O or S; where any carbon or heteroatom of R1. R2, R3, R4, R5, R6, R7, R8, R9 is unsubstituted or is substituted with one or more substituents independently selected from C1-C6alkyl, C1-C6haloalkyl, halogen, -OR10, -NR5R6, oxo, cyano, nitro, -C(O)R10, -C(O)OR10, -SR10, -S(O)R10, -S(O)2R10, -NR5R6, -CONR5R6, -N(R5)C(O)R10, -N(R5)C(O)OR10, -OC(O)NR5R6, -N(R5)C(O)NR5R6, -SO2NR5R6, -N(R5)SO2RK', C2-C10alkenyl, C2-C10alkynyl, C3-C6cycloalkyl, Cj C'sheterocycloalkyl, aryl, C1-C6alkyl-aiyl, heteroaryl and C1-C6alky 1-heteroaryl, wherein R5 and R6 are the same as defined above and R10 is selected from hydrogen, C1-C10alkyl, C2-C10alkenyl, C2-C10alkynyl, C(O)C1-C4alkyl, -C(O)aryl, -C(O)heteroaTyl, -C(O)C3--C6cycloalkyl, -C(O)C3-C6heterocycloalkyi, -S(O)2C,-C4alkyl, C3-C8cycloalkyl, C3-C8heterocycloalkyl, C6-C14aryl, aryl-C1-C10alkyl, heteroaryl and heteroaryl-C1-C10alkyl; and/or a pharmaceutically acceptable salt or solvate thereof. 2. A compound according to claim 1 wherein: X is O; Y is O; R1 and R4 are each independently selected from the group consisting of hydrogen, C1-C10aucyl, C2-C10alkenyl, C2-C10alkynyl, C3-C8cycloalkyl, C3-C8cycloalkyl-C1-C10aLkyl, C5-C8cycloalkenyl, C5-C8cycloalkenyl~C1-C10alkyl, C3-C8heterocycloalkyl, C3-C8heterocycloalkyl-C1-C10alkyl, aryl, aryl-C1-C10alkyl, heteroaryl and heteroaryl-C1-C10alkyl; R2 is -NR7R8 or -OR9; R3 is H or C1-C4alkyl; where R7 and R8 are each independently selected from the group consisting of hydrogen, C1-C10alkyl, C2-C10alkenyl, C2-C10alkynyl, C3-C8cycloalkyl, C3-C8heterocycloalkyl, aryl and heteroaryl, and R9 is H OT a cation, or C1-C10alkyl which is unsubstituted or substituted with one or more substituents independently selected from the group consisting of C3-C6cycloalkyl. heterocycloalkyl, aryl and heteroaryl, where any carbon or heteroatom of R1, R2, R3, R4, R7, R8, R9 is unsubstituted or is substituted with one or more substituents independently selected from C1-C6alkyl, C1-C6haloalkyl, halogen, -OR10, -NR5R6, oxo, cyano, nitro, -C(O)R10, -C(O)OR10, -SR10, -S(O)R10, -S(O)2R10, -NR5R6, -CONR5R6, -N(R5)C(O)R!0, -N(R5)C(O)OR10, -OC(O)NR5R6, -N(R5)C(O)NR5R6. -SO2NR5R6, -N(R5)SO2R10, C2-C10alkenyl, C2-C10alkynyl, C3-C6cycloalkyl, C3-C6heterocycloalkyl, aryl, C3-C6alkyl-aryl, heteroaryl and C1-C6alkyl-heteroaryl, wherein R\ and R are as defined in claim 1 and RH is selected from hydrogen, C1-C10alkyl, C2 -C10alkenyl, C2-C10alkynyl -C(O)C1-C4 alkyl, -C(O)aryl, -C(O)heteroaryl, -C(O)C3-C6cycloalkyl, -C(O)C3-C6heterocycIoalkyl, S(O)2C, C4 alkyl, C3-C8cycloalkyl, C3-C8heterocycloalkyl, C6-C14aryl, aryl-C1-C10alkyl, heteroaryl and heteroaryl-C1-C10alkyl; and/or a pharmaceutically- acceptable salt or solvate thereof. 3. A compound according to claim 1 wherein: X is O; Y is O; R1 and R4 are each independently selected from the group consisting of hydrogen, C1-C10alkyl, C2-C10alkenyl, C2-C10alkynyl, C3-C8cycloalkyi, C3-C8cycloalkyl-C1-C10atkyl, C5-C8cycloalkenyl, C5-Cscycloalkenyl-C1-C10aikyl, C3-C8heterocycloalkyl, C3-C8beterocycloalkyl-C1-C10alkyl, aryl, aryl-C1-C10alkyl, heteroaryl and heteroaryl-C1-C10alk.yl; R2 is -OR9; R3 is H or C1-C4alkyl; R9 is H or a cation, or C1-C10alkyl which is unsubstituted or is substituted with one or more substituents independently selected from the group consisting of C3-C6 cycloalkyl, heterocycloalkyl, aryl and heteroaryl, where any carbon or heteroatom of R1, R2, R3. R , R9 is unsubstituted or is substituted with one or more substituents independently selected from C1-C6alkyl, C1-C6haloalkyl, halogen, -OR10, -NR5R6, oxo, cyano, nitro, -C(O)R10, -C(O)OR10. -SR!0, -S(O)R10, -S(O)2R10 -NR5R6, -CONR5R6, -N(R5)C(O)R10, -N(R5)C(O)OR10, -OC(O)NRjR6, -N(R5)C(O)NR5R6, -SO2NR5R6, -N(R5)SO2R10, C2-C10 alkenyl, C2-C10 alkynyl, C1-C6eycloalkyl, C3-C6eterocycloalkyl, aryl, C1-C6alkyl-aryl, heteroaryl and C1-C6 alkyl-heteroaryl, wherein R5, and R are the same as defined in claim 1 and R1U is selected from hydrogen, C1-C10alkyl, C2-C10alkenyl, C2.C10alkynyl, -C(O)C1-C4alkyl, -C(O)aryl, -C(O)heteroaryl, -C(O)C3-C6cycloalkyl, -C(O)C3-C6heterocycloalkyL -S(O)2C,-C4alkyl, C3~C8cycloalkyl, C3-C8heterocycioalkyl, C6-C14aryl, aryl-C1-C10alkyl, heteroaryl and heteroaryl-C1-C10alkyl; and/or a pharmaceutically acceptable salt or solvate thereof. 4. A compound according to claim 1 wherein: X is O; Y is O; R1 and R4 are each independently selected from the group consisting of hydrogen, C1-C10alkyl, C2-C10alkenyl, C2-C10alkynyl, C3-C8cycloalkyl, C3-C8cycIoalkyl-C1-C10alkyl, C3-C8cycloalkenyl, C5-C8cycloalkenyl-C1-C10alkyl, C3-C8heterocycloalkyl, C3-C8heterocycloalkyl-C1-C10alkyl, aryl, aryl-Ci.C10alkyl, heteroaryl and heteroaryl-C1-C10alky!; R2 is -OR9; R3 is H; R9 is H or a cation; where any carbon or heteroatom of Rl, R\ R\ R~ is unsubstituted or is substituted with one or more substituents independently selected from C1-C6alkyl, C1-C6haloalkyl, halogen, -OR10, -NRSR6, oxo, cyano, nitro, -C(O)Rl°, -C(O)OR10, -SR10, -S(O)R10, -S(O)2R10, -NR5R6, -CONR5R6, -N(R5)C(O)R10; -N(Rs)C(O)OR10, -OC(O)NR5R6, -N(R5)C(O)NR5R6, -SO2NR5R6, -N(R5)SO2R10, C2-C10alkenyl, C2-C10alkynyL C3-C6cycloalkyl, C3-C6heterocycloalkyl, aryl, C1-C6alkyl-aryl, heteroaryl and C1-C6 alkyl-heteroaryl, wherein R5, and R6 are the same as defined in claim 1 and R10 is selected from hydrogen, C1-C10alkyl, C2-C10alkenyl, C2-C10alkynyl, -C(O)C1-C4allcyl, -C(O)aryl, -C(O)heteroaryl, -C(O)C3-C6cycloalkyl, -C(O)C3-C6heterocycloalkyL -S(O)2C1-C4 alkyl, C3-C8 cycloalkyl, C3-C8heterocycloalkyl, C6-C14 aryl, aryl-C1-C10allcyl, heteroaryl and heteroaryl-C1-C10alkyl; and/or a pharmaceutically acceptable salt or solvate thereof. 5. A compound according to claim 1 which is selected from: N- {[1 -(4-chlorophenyl)-6-hydroxy-2,4-dioxo-3-(phenylmethyl)-1,2,3,4-tetrahydro-5-pyrimidinyljcarbonyl} glycine; N-{[l-{[2,4-bis(methyloxy)phenyl]methyl}-6-hydroxy-2,4-dioxo-3-(phenylmethyl)-l,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl}glyeine; N-{[l-(4-chlorophenyl)-6-hydroxy-4-oxo-3-(phenylmethyl)-2-thioxo-l,2,3,4-tetrahydro-5-pyrimidinyljcarbonyl} glycine; N-( {6-hydroxy-2,4~dioxo-3-(phenylmethyl)-1 -[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydro-5-pyrimidinyl}carbonyl)glycme; N-{[6-hydroxy-2)4-dioxo-3-(phenylmethyl)-l,2,3,4-tetrahydroo-pyrimidinyl]carbonyl} glycine; N-{[6-hydroxy-2,4-dioxo-l-phenyl-3-(phenylmethyl)-l ,2,3,4-tetrahydro-5-pyrimidinyljcarbonyl} glycine; and A-[(l-(1,1-dimethyl ethyl)-3- {[4-(l, 1 -dimethylethyl)phenyl]methyl}-6-hydioxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycine; and/or a pharmaceutically acceptable salt or solvate thereof. 6. A compound according to claim 1 which is selected from: iV-{[6-Hydroxy-2,4-dioxo-3-(phenylmethyl)-l-(2-pyridinyl)-l,2,3,4-tetrahydro-5-pyrimidiny l]carbonyl} glycine, N-{[6-Hydroxy-l-(2-nitrophenyl)-2,4-dioxo-3-(phenylmethyl)-l,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine; iV- {[1 -Cyclohexyl-6-hychoxy-2,4-dioxo-3-(pheny lmethyl)-1,23,4-tetrahydro-5-pyrimidinyljcarbonyl} glycine; iV-{[l-[(3-Cyanophenyl)methyl]-6-hydroxy-2,4-dioxo-3-(phenylmethyl)-1,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine; N-[(6-Hydroxy-2,4-dioxo-3-(phenylmethyl)-1 - {[4-(trifluoromethyl)phenyl]methyl} -l,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycine; N-{[l-[(3,4-Dichlorophenyl)methyl]-6-hydroxy-2,4-dioxo-3-(phenylmethyl)-1,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine; N-{[6-Hydroxy-l-{[3-(methyloxy)phenyl]methyl}-2,4-dioxo-3 (phenylmethyl)-1,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine; N- {[1 -[(2,6-Dichlorophenyl)methyl]-6-hydroxy-2,4-dioxo-3-(phenylmethyl)-1,2,3,4-tetrahydro-5-pyTimidinyl]carbonyl} glycine; N- {[6-Hydroxy-1 -methyl-2,4-dioxo-3-(phenylmethyl)-1,2,3,4-tetrahydro-5-pyrimidiny Ijcarbonyl} glycine; N-{[l-Cyclohexyl-3-(2-cyclopropylethyl)-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyljcarbonyl} glycine; N-[(l,3-Dicyclohexyl-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycine; N-{[l-Hexyl-6-hydroxy-2,4-dioxo-3-(phenylmethyl)-l,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine; N-{[l-Ethyl-6-hydroxy-2,4-dioxo-3-(phenylmethyl)-l,2,3,4-tetrahydTO-5-pyrimidinyl]carbonyl} glycine; N-{[6-Hydroxy-2,4-dioxo-3-(phenylme1hyl)-1-propyl-1,2,3,4-tetrahy dro-5-pyrimidiny Ijcarbonyl} glycine; N-{[l-Butyl-6-hydroxy-2,4-dioxo-3-(phenylmethyl)-l,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine; N- {[6-Hydroxy-2,4-dioxo-1 -(2-phenylethyl)-3-(phenylmethyl)-1,2,3,4-tetrahydro-5 -pyrimidiny Ijcarbonyl} glycine; N-{[3-{[4-(l,l-Dimethylethyl)phenyl]methyl}-6-hydroxy-l-('l-methylethyl)-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl}glycine; N-[(l-cyclohexyl-3-{[4-( 1,1-dimethylethyl)phenyl]methyl}-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycine; N-{[6-Hydroxy-l,3-bis(l-methylethyl)-2,4-dioxo- l,2,3,4-tetrahydro-5-pyrimidinyljcarbonyl} glycine; N- {[3-[(2-BTomophenyl)methyl]-1 -(1,1 -dimethylethyl)-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl}glycrne; N-[(l-(2,6-DichJorophenyl)-3-{[4-(l,l-dimethylethyl)phenyl]methyl}-6-hydroxy~2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycine; N-[(l -(2,4-dichlorophenyl)-3- {[4-(l, 1 -dimethylethyl)phenyl]methyl} -6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycine; N-[(l-(2-Bromophenyl)-3-{[4-(l,l-dimethylethyl)phenyl]methyl}-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycine; N-[(l-(2-Biphenylyl)-3-{[4-(l,l-dimethylethyl)phenyl]methyl}-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycine; N- {[6-Hydroxy-2,4-dioxo-3-(phenylmethyl)-1 -(tetrahydro-2N-pyran-4-yl)-l ,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine; N- {[3-Cyclohexyl-6-hydroxy-2,4-dioxo -1 -(tetrahydro-2N-pyran-4-y 1)-1,2,3,4-tetrahydro-5-pyrimidiny l]carbonyl} glycine; N-{[3 - {[4-( 1,1 -Dimethylethyl)pheny ljmethyl} -6- hydroxy-2,4-dioxo-1 -(2-thieny 1)-1,2,3,4-tetrahydro-5-pyriniidinyl]carbonyl} glycine; N-({l-Cyclohexyl-6-hydroxy-3-[3-(4-morpholmyl)propyl]-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidiny 1} carbony l)glycine; N-{[3-{[4-(l,l-Dimethylethyl)phenyl]methyl}-6-hydroxy-2,4-dioxo-l-(3-pyridinyl)-1,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine; N-({l-Cyclohexyl-3-[(2-fluorophenyl)methyl]-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl}carbonyl)glycine; N-({3-[(2-Chlorophenyl)methyl]-l-cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl} carbony l)glycine; N-({l-Cyclohexyl-6-hydroxy-2,4-dioxo-3-[(5,5,8,8-tetramcthyl-5,6,7,8-tetrahydro-2-naphthalenyl)methyl]-1,2,3,4-tetrahydro-5-pyrimidinyl} carbonyl)glycine; N-({ 1 -Cyclohexyl-3-[(2,4-dimethylphenyl)methyl]-6-hydroxy-2,4-dioxo-l ,2,3,4-tetrahydro-5 -pyrimidinyl} carbony l)gly cine; N-({l-Cyclohexyl-6-hydroxy-2,4-dioxo-3-[(2,4,6-trifluorophenyl)methyl]-1,2,3.4-tetrahydro-5-pyrimidinyl}carbonyl)glycine; N-[(l-Cyclohexyl-6-hydroxy-3-{[4-(l-methylethyl)phenyl]methyl}-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycine; N-({l-Cyclohexyl-3-[(2-ethylphenyl)methyl]-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl}carbonyl)glycine; N-({l-Cyclohexyl-3-[(4-ethylphenyl)methyl]-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl} carbonyl)glycine; N-({l-Cyclohexyl-6-hydroxy-2,4-dioxo-3-[(2,4,6-trimethylphenyl)methyl]-l,2,3,4-tetrahydro-5-pyrimidinyl}carbonyl)glycine; N-{[l-Cyclohexyl-3-(2-cyclohexylethyl)-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine; N-[(3-{[3,5-Bis(methyloxy)phenyl]methyl} l-cyclohexyl-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycine; N-{[l-Cyclohexyl-6-hydroxy-3-(2-naphthalenylmethyl)-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyljcarbonyl} glycine; N-({l-Cyclohexyl-6-hydroxy-3-[(4-methylphenyl)methyl]-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl} carbonyl)glycine; N- {[3-(4-Biphenylylmethyl)-1 -cyclohexyl-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine; N-[(3-{[4-(l,3-Benzoxazol-2-yl)phenyl]methyl}-l-cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycine; N-({3-[2-(4-Biphenylyl)-2-oxoethyl]-l-cyclohexyl-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl}carbonyl)glyciiie; N-[(l,3-Bis{[4-(l,]-dimethylethyl)phenyl]methyl}-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycine; N-{[l-Cyclohexyl-6-hydroxy-3-(4-methylcyclohexyl)-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine; N-({l-Cyclohexyl-3-[4-(l,l-dimethylethyl)cyclohexyl]-6-hydroxy-2,4-dioxo-l,2,3,4-tetTahydro-5-pyrimidinyl) carbonyl)glycine; N-[(l-Cyclohexyl-6-hydroxy-2,4-dioxo-3-phenyl-l,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycine; N-({l-Cyclohexyl-3-[4-(l,l-dimethylethyl)pheriylj-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl}carbonyl)glycine; N-{[l-Cyclohexyl-3-(cyclohexylmethyl)-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl}glycine; N-[(3-Cycloheptyl-l -cyclohexyl-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycine; N-[(3-Cyclohexyl-6-hydroxy-2,4-dioxo-] .-tricyclo[3.3.1.1 *'idee-1-y 1-1,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycine; N-({l-[(lJR,2JR,45)-Bicyclo[2.2.1]hept-2-y)]-3-cyelohexyl-6-hydroxy-2,4-dioxo-1,2,3,4-tetTahydro-5-pyrimidinyl}caTbonyl)glycine, N-{[l-Cyclohexyl-6-hydroxy-3-(3-methylcyclohexyl)-2,4-dioxo~],2,3,4-tetrahydro-5-pyrimidinyljcarbonyl} glycine; N-[(3-Cyclohexyl-l-cyclopropyl-6-hydroxy-2,4-dioxo-l,23,4-tetrahydro-5-pyximidinyl)carbonyl]glyeine; N-[(l-Cyclobutyl-3-cyclohexyl-6-hydioxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidiny l)carbony l]glycine; N-[(3-Cyclohexyl-l-cyclopentyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycine; N-{[6-Hydroxy-l,3-bis(3-methylbutyl)-2,4-dioxo-l,2:3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine; N-[(6-Hydroxy-1,3-bis{[2-(methyloxy)phenyl]methyl} -2,4 dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycine; N-({l,3-Bis[(2-chlorophenyl)methyl]-6-hydroxy-2,4-dioxo-1.2,3»4-tetrahydro-5-pyrimidinyl}carboiiyl)glycine; N-[(l,3-Dihexyl-6-hydioxy-2,4-dioxo-l,2,3,4-tetrahydro-5-p>Timidmyl)carbonyl]glycine; N-{[l-Cyclohexyl-6-hydroxy-3-(2-methylcyclohexyl)-2,4-dioxo-l ,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine; N- {[l-Cyclohexyl-6-hydroxy-3-(2-naphthalenyl)-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine; N-[(l-Cyclohexyl-3-hexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro--5-pyrimidinyl)carbonyl]glycine; N-[(l,3-Dicycloheptyl-6-hydroxy-2,4-dioxo-1,2,3,4-tctrahydro-5-pyrimidinyl)carbonyl]glycine; N-[(l,3-Dicyclopentyl-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyTimidinyl)carbonyl]glycine; N-{[l-Cyclohexyl-3-(2,3-dimethylcyclohexyl)-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine; 4-[5-{[(Carboxymethyl)amino]carbonyl}-3-cyclohexyl-4-hydroxy-2,6-dioxo-3,6-dihydro-1 (2/f)-pyrimidinyl]cyclohexanecarboxylic acid; N-{[l-Cyclohexyl-3-(4-ethylcyclohexyl)-6-hydrory-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine; cis-4-[3-Cyclohcxyl-5-({[2-(ethyloxy)-2-oxoethyl]amino}carbonyl)-4-hydroxy-2,6-dioxo-3,6-dihydro-1 (2/f)-pyrimidinyl]cyclohexanecarboxylic acid; N-{[l-Cyclohexyl-6-hydroxy-3-(l-methylcyclohexyl)-2,4-dioxo-1,2,3,4-tetrahydTo-5-pyrimidinyl]carbonyl} glycine; 3-[5-{[(CaTboxymethyl)amino]carbonyl}-3-cyclohexyl-4-hydroxy-2,6-dioxo-3,6-dihydro-1 (2H)-pyrimidia.yl]cyclohexanecarboxylic acid; N-{[l-Cyclohexyl-6-hydroxy-2,4-dioxo-3-(2-oxo-2-phenylethyl)-l,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine; N-[(l-Cyclohexyl-6-hydroxy-3- {2-[4-(methyloxy)phenyl]-2-oxoethyl}-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)carbony ljglyc ine; N-({l-Cyclohexyl-6-h.ydroxy-3-[2-(4-methylphenyl)-2-oxoethyl]-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl}carbonyl)glycme; N-{[l-Cyclohexyl-3-(3,3-dimethyl-2-oxobutyl)-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine; N-({l-Cyclohexyl-3-[2-(4-fluorophenyl)-2-oxoethyl]-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydTO-5-pyrimidinyl}carbonyl)glycine; N-({3-[2-(4-Cyanophenyl)-2-oxoethyl]-l-cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl}carbonyl)glycine; N-({3-[2-(l-Benzofuran-2-yl)-2-oxoethyl]-l-cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl}carbonyl)glycine; N-{[3-Cyclohexyl-6-hydroxy-l-(l-naphthalenyl)-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine; N-{[3-Cyclohexyl-l-(4,4-dimethylcyclohexyl)-6-hydroxy-2,4-dioxo-l,2)3,4-tetrahydro-5-pyriimdinyl]carbonyl} glycine; N-({l-Cyclohexyl-3-[(2,3-difluorophenyl)methyl]-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl}carbonyl)glycine; Ethyl N-[(l,3-dicyclohexyl-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)carbonothioyl]glycinate; N-[(l,3-Dicyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5~ pyrimidinyl)carbonothioyl]glycine; 6-[5-{[(Carboxymethyl)amino]caibonyl}-3-cyclohexyI-6-hydroxy-2,4-dioxo-3,4-dihydro-l(2H)-pyrimidmyl]hexanoic acid; 6-[5-{[(Caiboxymethyl)amino]carbonothioyl}-3-cyclohexyl-6-hydroxy-2,4-dioxo-3,4-dihydro-1 (2H)-pyrimidinyl]hexanoic acid; N-({l-Cyclohexyl-3-[(3,4-dichlorophenyl)methyl]-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl}carbonyl)glycine: N-[(l-Cyclohexyl-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycine; N-({3-Cyclohexyl-6-hydroxy-l-[fra;w-4-(methyloxy)cyclohexyl]-2,4-dioxo-l ,2,3,4-tetrahy dro-5 -pyrimidinyl} carbonyl)glycine: N-({l-[l,r-Bi(cyclohexyl)-4-yl]-3-cyclohexyl-6-hydTOxy-2,4-diox.o-l,233,4-tetTahydro-5-pyrimidinyl} carbonyl)glycine; N- {[6-Hydroxy-2,4-dioxo-1,3-bis( 1 -propylbuty I)-1 ,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine; N-({3-(2-Cyclopropylethyl)-6-hydroxy-1 -[3-(methyloxy)phenyl]-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidmyl}carbonyl)glycine; N- {[3-Cyclohexyl-6-hydroxy-2,4-dioxo-1 -(4-phenylcyclohexyl)-1,2,3,4-tetrahydro-5-pyrimidinyljcarbonyl} glycine; N'-({l-Cyclohexyl-3-[(3,4-difluorophenyl)methyl]-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl}carbonyl)glycine; N-({3-(2-Cyclopropylethyl)-6-hydroxy-l-[4-(methyloxy)phenyl]-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidmyl}carbonyl)glycine; N-{[3-(2-Cyclopropylethyl)-6-hydroxy-l-(3-ni1rophenyl)-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine; N-({3-(2-Cyclopropylethyl)-6-hydroxy-2,4-dioxo-l-[4-(2-thienyl)phenylJ-l,2,3,4-tetrahy dro-5-pyrimidiny 1} carbonyl)glycine; N-{[l,3-Bis(l-ethylpropyl)-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl}glycine; N-[(6-Hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycine; N-[(l-Cyclohexyl-6-hydroxy-2,4-dioxo-3-{[4-(trifluoromethyl)phenyl]methyl}-1,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycine; N-[(l,3-Dibutyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycine; N-{[l,3-Bis(2-cyclopropylethyl)-6-hydroxy-2,4-dioxo-1.2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine; N-{[6-Hydroxy-l,3-bis(2-methylpropyl)-2,4-dioxo-l,2,3,4-tetrahydro-5 pyrimidinyl]carbonyl} glycine; N-({3-(2-Cyclopropylethyl)-6-hydroxy-l-[3-(5-methyl-l,2,4-oxadiazol-3-yl)phenyl]-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidmyl} carbonyl)glycine; N-({3-(2-Cyclopropylethyl)-6-hydroxy-l-[4-(2-methyl-l,3-thiazol-4-yl)phenyl]-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl}carbonyl)glycme; N-{[3-Cyclohexyl-6-hydroxy-2,4-dioxo-l-(4-piperidinyl)-l,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine; N-({3-(2-Cyclopropylethyl)-l-[4-(2-furanyl)phenyl]-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl}carbonyl)glycine; N-{[l,3-Bis(l,l-dimethylpropyl)-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl} glycine; N- {[3-Cyclohexyl-6-hydroxy-2,4-dioxo-1 -(3-piperidinyl)-1,2,3,4-tetrahydxo-5-pyrimidinyl]carbonyl}glycine; N-{[3-Cyclohexyl-6-hydroxy-2,4-dioxo-l-(l -{[(phenylmethyl)oxy]carbonyl}-3-piperidiny^-l,2,3,4-tetrahydro-S-pyrimidinyljcarbonyl} glycine; N-{[l-(l-Acetyl-3-piperidinyl)-3-cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyljcarbonyl} glycine; N-[(1-Cyclohexyl-3-{[4-fluoro-2-(trifluoromethyl)phenyl]methyl}-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycine; N-({3-[(2-Bromophenyl)methyl]-l-cyclohexyl-6-hydroxy-2,4-dioxo-l,2s3,4-tetrahydro-5-pyrimidinyl}carbonyl)glycine; N-({l-Cyclohexyl-3-[(2,6-dichlorophenyl)methyl]-6-hydroxy-2,4-dioxo-1,2,3,4 tetrahydro-5-pyrunidinyl}carbonyl)glycine; N-[(3-{[2~Bromo-5-(methyloxy)phenyl]methyl}~! -cyclobexyl-6 hydroxy-2,4-dioxo-l,2,3,44etrahyoTO-5-pyTimidinyl)caroonyl]glycme; N-[(3- {[2,4-Bis(trifluoromethyl)phenyl]methyl} -1 -cyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyTimidinyl)carbonyl]glycine; N-({3-[(2-Bromo-5-fluorophenyl)methyl]-l-cyclohexyl-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidmyl}carbonyl)glycine; N-[(3- {[2-Bromo-4-(l, 1 -dimethylethyl)phenyl]methyl} -1 -cyclohexyl-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]gly cine; N-({l-Cyclohexyl-6-hydroxy-3-[(2-methylphenyl)methyl]-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl}carbonyI)glycine; N-{[l-Gyclohexyl-3-(l,l-dimethylpropyl)-6-hydroxy-2,4-dioxo-l,2,3,4-tetrahydro-5-pyrimidinyl]caxbonyl} glycine; and N- {[1,3-Bis(2,6-dichlorophenyl)-6-hydroxy-2,4-dioxo~ 1,2,3,4-tetrahycb o-5 pyrimidinyl]caibonyl}glycine: and/or a pharmaceutically acceptable salt or solvate thereof 7. A pharmaceutical composition which comprises a compound as described in claim 1 and one or more of pharmaceutically acceptable carriers, diluents and excipients. 8. A process for preparing a pharmaceutical composition containing a pharmaceutically acceptable carrier or diluent and an effective amount of a compound as described in claim 1 which process comprises bringing the compound as described in claim 1 into association with a pharmaceutically acceptable carrier or diluent. 9. A process for preparing a compound of formula (I) (Formula Removed) wherein: R1and R4 are each independently selected from the group consisting of hydrogen, -NR'R , C1-C10alkyl, C2„Cioalkenyl, C2-C10alkynyl, C3-C8cycloalkyl, C3-C8cycloalkyl-C1-C10alkyl, C5-C8cycloalkenyl, C5-C8Cycloalkenyl-C1-C10alkyl, C5-C8heterocycloalkyl, C3-C8heterocycloalkyl- C1-C10alkyU aryl, aryl-C1-C10alkyl, heteroaryl and heteroaryl-C1-C10alkyl; R2 is -NR7R8 OR -OR9; R3 is H or C1-C4alkyl; where R5 and R6 are each independently selected from the group consisting of hydrogen, C1-C10alkyl, C3-Cgcycloalkyl, C3-C8cycloalkyl-C1-C10alkyl, C3-C8heterocycloalkyl, C3-C8heterocycloalkyl-C1-C10alkyI, aryl, aryl-C1-C10alkyl, heteroaryl, heteroaryl- C1-C10alkyl, -CO(C1-C4alkyl), -CO(C3-C6cycloalkyl), -CO(C3-C6heterocycloalkyl), -CO(aryl), -CO(heteroaryl) and -SO2(C1-C4alkyl), or, when R5 and R6 are attached to the same nitrogen, R5 and R6 taken together with the nitrogen to which they are attached form a 5- or 6- or 7-membered saturated ring optionally containing one other heteroatom selected from oxygen, nitrogen and sulphur, R7 and R8 are each independently selected from the group consisting of hydrogen, C1-C10alkyl, C2-C10alkenyl, C2-C10alkynyl, C5-C8cycloalkyl, C3-C8heterocycloalkyl, aryl and heteroaryl, and R9 is H or a cation, or C1-C10alkyl which is unsubstituted or substituted with one or more substituents independently selected from the group consisting of CVCscycloalkyl, heterocycloalkyl, aryl and heteroaryl; X is O or S; and Y is O or S; where any carbon or heteroatom of R1, R2, R3, R4, R5,R6, R7, R8, R9 is unsubstituted or is substituted with one or more substituents independently selected from C1-C6alkyl, C1-Cghaloalkyl, halogen, -OR10, -NR5R6, oxo, cyano, nitro, -C(O)R10, -C(O)ORl0, -SR10, -S(O)R10, ~S(O)2R10, -NR5R6, -CONR5R6, -N(R5)C(O)R10, -N(R5)C(O)OR10, -OC(O)NR5R6, -N(R5)C(O)NR5R6, -SO2NR5R6, ~N(R5)SO2R10, C2-C10alkenyl, C2-C10alkynyl, C3-C6cycloalkyl, C3-C6heterocycloalkyl, aryl, C1- C6alkyl-aryl, heteroaryl and C1-C6alkyl-heteroaryl, wherein R3 and R6 are the same as defined above and R10 is selected from hydrogen, C1-C10alkyl, C2_C10alkenyl, C2-C10alkynyl, -CO(C1-C4alkyl), -CO(aryl), -CO(heteroaryl), -CO(C3-C6cycloalkyl), -CO(C3-C6heterocycloalkyl), -SO2(Cr C4alkyl), C3-C8cycloalkyl, C3-C8eterocycloalkyl, C6-C]4aryl, aryl-C1-C10alkyl, heteroaryl and heteroaryl-C1-C10alkyl; comprising treating a compound of formula A: (Formula Removed) wherein Rl and R4 are the same as for those groups in formula (I) with glycine and an appropriate base in an appropriate solvent under conventional thermal conditions or by microwave irradiation, to form the compound of formula (I). 10. A process for preparing a compound of formula (I) (Formula Removed) wherein: R1and R4 are each independently selected from the group consisting of hydrogen, -NRR6, C1-C10alkyl, C2.Ctoalkenyl, C2-C10alkynyl, C3-C8eycloaLky], C3-C8cycloalkyl-C1-C10alkyl, C5-C8cycloaLkenyl, C5-C8cycloalkenyl-C1-C10alkyI, C3-Csheterocycloalkyl, C3-C8heterocycloalkyl- C1-C10alkyl, aryl, aryl-C1-C10alkyl, heteroaryl and heteroaryl-C1-C10alkyl; R2 is -NR7R8 or -OR9: R3 is H or C1-C4alkyl; where R5 and R6are each independently selected from the group consisting of hydrogen, C1-C10alkyl, C3-C8CycIoalkyl, C3-C8Cyck>alkyi-C1-C10alky], C3~C8heterocycloalkyl, C3-C8hetetocycloaLkyl-C1-C10alkyl, aryl, aryl-C1-C10alkyl, heteroaryl, heteroaryl- C1-C10alkyl, -CO(C1-C4alkyl), -CO(C3-C6cycloalkyl), -CO(C3-C6heterocycloalkyl), -CO(aryl), -CO(heteroaryl) and -SO2(C1-C4alkyl), or, when R' and R6 are attached to the same nitrogen, R5 and R6 taken together with the nitrogen to which they are attached form a 5- or 6- or 7-membered saturated ring optionally containing one other beteroatom selected from oxygen, nitrogen and sulphur, R7 and R8 are each independently selected from the group consisting of hydrogen, C1-C10alkyl, C2-C10alkenyl, C2-C10alkynyl, C3-C8cycloaIkyl, C3-C8heterocycloalkyl, aryl and heteroaryl, and R9 is H or a cation, or C1-C10alkyl which is unsubstitured or substituted with one or more substituents independently selected from the group consisting of C3-C6cycioaikyl heterocycloallcy], aryl and heteroaryl; X is O or S; and Y is O or S; where any carbon or heteroatom of R1, R2, R3, R4, R4 ,R6, R7, R8, R9 is unsubstituted or is substituted with one or more substituents independently selected from C1C6alkyl, C1-C6haloalkyl, halogen, -OR10, -NR5R6, oxo, cyano, nitro, -C(O)R10, -C(O)OR10, -SR10, -S(O)R10, -S(O)2R10, -NR5R6, -CONR5R6, -N(R5)C(O)R10, -N(R5)C(O)OR10, -OC(O)NR5R6, -N(R5)C(O)NR5R6, -SO2NR5R6, -N(R5)SO2R10, C2-C10alkenyl, C2-C10alkynyl, C3-C6cycloalkyl, C3-C6heterocycloalkyl, aryl, C1-C6alkyl-aryl, heteroaryl and C1-C6alkyl-heteroaryl, wherein R5 and R6 are the same as defined above and R10 is selected from hydrogen, C1-C10alkyl, C2-C10alkeny], C2-C10alkynyl, -CO(C1-C4aiky!), -CO(alyl), -CO(heteroaryl), -CO(C3-C6cycloalkyl), -CO(C3~Csheterocycloalkyl), -SO2(C1-C4alkyl), C3-C8cycloalkyl, C3-C8heterocycloalkyl, C6-Ci4aryl, aryI-Ci_C10alkyl, heteroaryl and heteroaryl-C1-C10alkyl; comprising treating a compound of formula B: (Formula Removed) wherein R1 and R4 are the same as for those groups in formula (I) with an alkali, in an appropriate solvent at a suitable temperature to form the compound of formula (I). |
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| Patent Number | 279762 | |||||||||||||||||||||
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| Indian Patent Application Number | 10555/DELNP/2008 | |||||||||||||||||||||
| PG Journal Number | 05/2017 | |||||||||||||||||||||
| Publication Date | 03-Feb-2017 | |||||||||||||||||||||
| Grant Date | 30-Jan-2017 | |||||||||||||||||||||
| Date of Filing | 22-Dec-2008 | |||||||||||||||||||||
| Name of Patentee | SMITHKLINE BEECHAM CORPORATION | |||||||||||||||||||||
| Applicant Address | ONE FRANKLIN PLAZA, PO BOX 7929, PHILADELPHIA, PENNSYLVANIA 19101, U.S.A. | |||||||||||||||||||||
Inventors:
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| PCT International Classification Number | A61K 31/515 | |||||||||||||||||||||
| PCT International Application Number | PCT/US07/071854 | |||||||||||||||||||||
| PCT International Filing date | 2007-06-22 | |||||||||||||||||||||
PCT Conventions:
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