Indian Patents. 216846:" AN AEROSOL COMPOSITION , PROCESS FOR ITS PREPARATION AND PRESSURIZED CAN COMPRISING IT"

Title of Invention	" AN AEROSOL COMPOSITION , PROCESS FOR ITS PREPARATION AND PRESSURIZED CAN COMPRISING IT"
Abstract	An aerosol composition which prepared from a biliquid foam an aqueous phase and a propellant. The incor poration of an oil soluble functional material into the biliquid foam during the prparation of the aerosol composition enables this material to be more readily incorporated into the composition.

Full Text	The present invention relates to aerosol delivery systems and, in particular, to aerosol delivery 5 system which are designed to reduce the amount of surfactant Included therein. Aerosol compositions are known in the art which contain oil soluble functional materials such as 10 fragrances, silicones, esters and bio-active materials. therein. In order to disperse the oil soluble functional material into the aqueous phase of the aerosol composition there is generally a requirement to include in the composition from two to three times 15 by weight of the functional material of a solvent or surfactant therein. We have now found that incorporation of the oil soluble functional material into a biliquid foam 20 enables this material to be readily dispersed throughout the aqueous phase of the aerosol composition without the use of excessive amounts of solvents or surfactants, which may affect the material and which may neutralize the effects of any 25 preservatives contained within the aerosol composition. Accordingly, the present invention provides an aerosol composition which is prepared from a biliquid 30 foam, an aqueous phase and a propellant. The invention also provides a pressurized aerosol can comprising an aerosol composition, of the invention. WO 2004/042227 PCT/GB2003/004806 - 2 - The invention also provides a process for preparing an aerosol composition of the invention which comprises adding the aqueous phase to a vessel, adding the biliquid foam to the vessel and mixing and 5 filling an aerosol can with the addition of a suitable propellent. Biliquid foam are known in the art and are described in the following literature references by 10 Sebba; "Biliquid foams", J. colloid and Interface Science, 40 (1972) 468-474; and "The Behaviour of Minute Oil Droplets Encapsulated in a Water Film" Colloid Polymer Sciences, 257 (1979) 392-396. 15 US Patent No., 4486333 to Sebba describes a particular method for the preparation of biliquid foams by agiating a hydrogen bonded liquid containing a soluble surfactant to produce a gas foam and Intermittently adding to the gas foam a non-polar 20 liquid which is immiscible with the hydrogen bonded liquid, the surfactant-containing hydrogen bonded liquid being selected to provide a spreading coefficient equal to or greater than zero. 25 The biliquid roam which is incorporated into the aerosol compositions of the present invention generally contains at least one oil soluble functional material therein. Examples of the oil soluble functional materials are fragrances, lubricants, 30 vegetable oils, fuels, silicones, esters and bio- active materials. The biliquid foam which is used in the present invention will preferably comprise from 70 to 95% by WO 2004/41227 PCT/GB2003/004806 - 3 - weight of the oil phase, which may consist solely of the oil soluble functional material, and 5 to 30% by weight of the continuous phase, which is preferably an aqueous phase. A surfactant to stabilise the biliquid 5 foam may also be included in an amount of from. 0 _ 1 to 3%, preferably 0.1 to 1% by weight based on the total weight of the formulation. Suitable surfactants are, for example, sodium lauryl ether sulphates, polyethoxylated castor oil, ethoxylated oleyl alcohols 10 or polyethoxylated hydrogenated castor oils. Propellents which are used in aerosol delivery systems are well known in the art and will preferably be liquified petroleum gas (LPG), Which is preferably 15 burane, optionally in admixture with propane. The propellant will generally be present in an amount of from 5 to 40% by weight. The aerosol compositions of the present invention 20 will generally include the biliquid foam in an amount of from o.1 to 10% by weight. The biliquid foam will therefore generally provide the desired oil soluble functional material in an amount of from 0. 07 to 9.5% by weight. 25 The invention, includes within its scope an aerosol composition which comprises from 0.01 to 40% by weight of the biliquid foam, from 5 to. 40% weight of the propellant and from 20 to 95% by weight of 30 water. The aqueous phase of the asroeol composition may include therein one or more surfactants or other additives. The surfaatant may be chosen to prevent WO 2004/041041227 PCT/GB2003/004806 - 4 - interaction of the propellant with the biliquid foam. Cationic surfactants are preferred, in particular quaternary ammonium compounds or amine oxides. Surfactants may also be choesn, to create an affinity 5 with the propellant. The aerosol compositions of the present invention may be packaged in cans which are well Known in the art and generally are formed of aluminium or lacquered 10 or unlacquered tin plate or the like. Methods of producing biliquict foam are described in US-A-4486333 involving the preliminary formation of a gas foam in order to provide a sufficiently large 15 surface area on which the biliquid foam can subsequently be formed. It has been found that the prior formation of a gas foam is not required to manufacture a stable biliquid foam, provided that a suitable stirring mechanism is provided in the 20 manufacturing vessel. Such an apparatus comprises a tank provided with a stirrer in which the stirrer blade breaks the interface between the liquid and air and provides low 25 shear mixing throughout the whole of the volume of the biliquid foam throughout the whole of the production process. A delivery device is provided through which the oil phase (non-polar liquid), which will comprise the internal phase of the dispersion is delivered to 30 the tank. The design of the delivery device is such that the rate of addition of the internal phase fluid can be controlled and varied during the production process. A feature of the production process is that the internal (oil) phase ia added to the stirred WO 2004/041227 PCT/GB2003/004806 - 5 - aqueous phase slowly at first until sufficient droplets have been formed to constitute a large, additional surface area for the more rapid formation of new droplets, At this point, the rate of addition 5 of the oil phase way be increased. The production process consists of the following steps: 10 1. The addition of one or more chosen surfactants to one or other or both, phases (as. previously determined by experiment) , 2. The charging of the aqueous phase into the bottom of a process vessel. 15 3. The incorporation of the stirrer into the vessel so that it stirs the surface of the aqueous phase. 4. Adjustment of the stirrer speed to a previously determined level. 20 5, The slow addition of the internal phase whilst continuing to stir at the prescribed speed. 6. The speeding up of the rate of addition of the oil phase once a prescribed amount 25 (usually between 5% and 10% of the total amount to be added) 1 as been added. The stirring rate and the rate of addition of the oil phase are variables, the values of which depend 30 upon the detailed design of the manufacturing plant (in particular, the ratio of tank diameter to impeller diameter) r the physical-chemical properties of the oil phase and the nature and concantrations of the choser,. surfactants . These can all be pre-determined by WO 2004/041227 PCT/GB2003/004806 - 6 - laboratory or pilot plant experiment. It will be understood by those skilled in the art that other manufacturing methods for the biliquid foam 5 may be used, as appropriate. The preparation of the biliquid foams proceeds independently of the preparation of the final aerosol compositions of the invention. The aerosol 10 compositions may be prepared by adding the aqueous phase optionally including one or more surfactants therein to a suitable vessel, adding the biliquid foam thereto and mixing. The composition so prepared is then filled into aerosol cans using techniques known 15 in the art. The. compositions are then pressurized in the aerosol cans, with the addition of a suitable propellant, using techniaques known in the art. The aerosol compositions of the present invention 20 will generally possess one or more of the following advantages: - the elimination of the need for the use of large amounts of solvents or surfactants and 25 volatile organic compounds. - the potential to reduce skin irritation in compositions which are to be applied to the skin; 30 - the possibility to include in the Composition oils which, would generally be incomptible with one another; WO 2004/041227 PCT/CB2003/004806 - 7 - - the possibility of using lower levels of fragrance components, whilst obtaining the same level of fragrance impact. 5 - the possibility of using lower levels of preservatives, whilst obtaining the same level of preservation. - better performing formulations which allow 10 dispensing using less propellant to achieve. similar results. The aerosol compositions of the invention are preferably used as or in polishes, particularly 15 furniture polishes, air fresheners, fragrances/ moisturisers, sunscreens, shaving preparations, or follicle softeners. The aerosol compositions of the invention may 20 contain other components (in addition to the biliquid foam aqueous phase and propellant) depending upon the uses to which they are to be put. Thus, where the aerosol compositions are to be used as polishes, the compositions may additionally contain waxes, for 25 example vegetable waxes (for example, carnauba and candelilla) , optionally combined with one or more softeners, fillers and pigments. one or more alcohols or other solvents may also be present. 30 Where the aerosal compositions are used. as furniture polishes, these may additionally contain one or more of silicone, red oil, lemon oil and petroleum solvent; nail polishes generally comprise nitrocellulose, optionally with amyl acetate solvent WO 2004/041227 PCT/GB2003/004806 - 8 - present. Where the aerosol compositions are used as air fresheners, a perfumed component (e.g. a free perfume) 5 will generally be present. In addition, such compositions may comprise one or more of the group comprising porosity modifiers, disintegrants, water- swelling agents and colourants. Also present may be inert fillers, hydroscopic agents. binders, coating 10 materials and moisture-providing agents, Where the compositions are used as repellents, these will generally comprise an active repellent agent: such as citronella oil, dimethyl phthalate, n- 15 butylmesityl oxide oxalate and l-ethyl hexane-1,3- diol. Actidione may be used as an active agent in rodent repellents as may thiuram disulfide amino complexes with trinitrobenzne and hexaohlorophene. 20 where the aerosol compositions are used as shaving preparations, appropriate additional components may be as described in Harry's Cosmeticology, 7th Ed; J, B. wilkinson and R-. J. Moore (editors), Chemical Publishers, New York, 1982, 25 pp. 126 - 189 . Sunscreens will generally comprise either of both of both a UV-A or UV-B filter. UV-A filters are generally derivates of dibenzoylmethanef particularly 30 avobenzene (4- (1,1 -dimethylethyl) -4'- methoxydibenzoylmethne, sold under the brand name PARSOL 1789) . Preferably, each of avobenzone, octyl salicylate and oxybenzoe is present. other diahabenzoymethane derivatives known be UV-A filters WO 2004/041227 PCT/GB2003/004806 - 9 - are described in US Patent Nos. 4,387,089, 4,489,057 and 4,562,057, UV-B filters are generally paramethoxycinnaic acid esters, such as 2-ethylhexyl paramethoxycinncimate, generally known as octyl methoxy 5 cinnamate ar PARSOL MCX, octyl salicyiate and oxybenzone- Follicle softeners generally comprise one or more of the following: surfactants, lubrictants, hunectants, 10 foaming agents, fragrances, fatty acids and bases. The contents of all publications referred to herein are hereby incorporated ay reference. 15 The present invention will be further described with reference to the following Examples, Examples 1 20 Preparation of biliquid foam A biliquid to foam was prepared from the following ingredients using the stirring mathod as described above. The aqueous phase was introduced into a beaker equipped with a stirrer, the diameter of which was 25 approximately 60% of the beaker diameter and the depth sufficient to provide mixing throughout the body of the biliquid foam once the oil addition was complete, to provide law shear mixing. The fragrance and surfactant were slowly added over a period of a few 30 minutes with Stirring continuing after completion of the oil addition until the sample became homogeneous. Oil Phase % w/w Fragrance 8.9.1 WO 2004/041227 PCT/GB2003/004806 - 10 - Castor oil/PoIyoxyethylene glycol 0.9 (35) adduct (Etocas 35 NF) Aqueous Phase 5 Demin. Water 9.90 Sodium lauryl ether sulphate (Standopol) 0.10 100.00 10 Preparation of Screening Aerosol Composition An aerosol formulation was prepared from the following ingredients: % w/w Biliquid foam 0.34 15 polyquaternium-11 (Gafquat 755N) 5.00 Isopentane 5.00 Water 89.66 100.00 20 The water was mixed with the polyquaternium-11 and the biliquid foam added. The isopentane was then added to the mixture. The mixture demonstrated the suitability of the invention for formulation as an aerosol composition using a suitable propellant to 25 replace the isopentane. Example 2 A screening aerosol formulation was prepared from 30 the following ingredients: % w/w Biliquid foam of Example 1 0.34 Polyquaterniunm-11 (Gafquat 755N) 0.10 Isopentane 5.00 WO 2004/041227 PCT/GB2003/004806 - 11 - Water 94.56 200.00 The water was mixed with the polyguaternium-11 5 and the biliquid foam added. The isopentane was then added to the mixture. _Example_ 3 10 A screening aerosol formulation was prepared from the following ingredients: % w/w Biliquid foam of Example 1 0.34 15 Polyquaternium-11 (Gafquat 755N) 0.05 Ispentane 5.00 Water 94.61 100 .00 20 The water was mixed with the polyquaternium-11 and the biliquid foam added. The isopentane was then added to the mixture. Example 4 25 A screening aerosol formulation was prepared from the following ingredients, % w/w Biliquid foam of Example 1 0.34 30 Polyquaternium-7 (Mackernium 007) 0.10 Isopentane 5.00 Water 94.56 100.00 WO 2004/041227 PCT/GB2003/001806 - 12 - The water was mixed with the polyquaternium-11 and the biliquid foam added. The isopentane wsa then added to the mixture. Example 5 5 A screening aerosol formulation was prepared from the. following ingrdients: % w/w Biliquid foam of Example 1 0.34 10 Dicetyl Dimonium Chloride (Proquat 868-P) 0.10 Isopentane 5.00 Water 94.56 100.00 15 The water was mixed with the polyquaternium-11 and the biliquid foam added. The isopentane was then added to the mixture. 20 Example 5 A screening aerosol formulation was prepared from the following ingredients: % w/w 25 Biliquid foam of Example 1 0.34 Amine oxide (Ao-455) 0.10 Isopentane 5.00 Water 95.94 100.00 30 The water was mixed with the polyquaternium-11 and the biliquid foam added. The isopentane was then edded to the mixture. WO 2004/04l227 PCT/GB2003/00-1806 - 13 - Example 7 A screening aerosol formulation was prepared from the following ingredients: 5 % w/w Biliquid foam of Example 1 0.34 Amine oxide (AO-455) 0.05 Isapentane 5.00 Water 94.51 10 100.00 The water was mixed with the polyquaternium-11 and the biliquid foam added. The isopsntane was then added to the mixture. 15 Example B A screening aerosol formulation was prepared from the fallowing ingredients: 20 %w/w Siliquid foam of Example 1 0.34 Vinyl caprolactam/PVP/Dimethyl- aminomethyl mathacrylate copolymer 0.10 Isopentane 5.00 25 Water 94.56 100.00 The water was mixed with the polyquaternim-11 and the biliquid foam added. The isopentane was then 30 added to the mixture. WO 2004/041227 PCT/GB2003/004806 - 14 - Example _9 A screening aerosol formulation was prepared from the fellowing ingredients: 5 % w/w Biliquid foam 0.34 0.34 Dimethyl lauryl amine oxide 0.10 Isopentane 5.00 Water 94.56 10 100.00 The water was mixed with the polyqaternium-11 and the biliquid foam added. The isopentane was then added to the mixture. 15 Example10 A screening aerosol formulation was prepared from the following ingredients: 20 %w/w Biliquid foam of example 1 0.34 Cocamidopropylamine oxide 0.10 Isopentane 5.00 Water 94.56 25 100.00 The water was mixed with the polyquaternium-11 and the biliquid foam added. The isopentane was then added to the mixture. 30 In a similar, manner to the procedding examples, further examples of aerosol compositions according to the invention are prepared from the following components : WO 2004/041227 PCT/GB2003/004806 - 15 - Example 11 : Furniture Polish % w/w 5 Mineral Oil 21.02 Deodorized Mineral Spirits 1.20 Silicone 4.50 Laureth –4 0.27 Sodium Lauryl Ether Sulfate 0.30 10 Preservative 0.56 Water 71.76 Carbormer 0.56 Triethanolamine 0.34 15 Example 12: Fragrance / Moisturizer %w/w Water 55.264 Denatured Alcohol 20 .00 20 Glycerin 2.00 Polyacrylamide and c13-14 Isopal affin and Laureth –7 0.60 Nylon-12 0.50 Titanium Dioxide 0.40 25 Glyceryl Trioctanoate 5.00 Isododecane 4.00 Silicone 6.00 Fragrance 6.00 PEG 25 Hydrogenated Castor Oil 0.106 30 PEG 25 Castor oil 0.106 Sodium Lauryl Ethar Sulfate 0.24 WO 2004/04227 PCT/GB2OO3/004806 - 16 - Example 13: Air Freshener % w/w Water 97.98 5 Carbomer 0.60 Triethanolamine 0.30 Preservative 0.10 Fragrance 0.45 Laureth –4 0.27 10 sodium Lauryl Ether sulphate 0.30 Example 14: sunscreen %w/w 15 Avobenzone 3.00 Octyl Salicylate 5.00 Oxybenzone 4.00 Dimethyhoxyl 2.6-Napthalate 5.00 sunflower oil 2.00 20 Cyclopentasiloxane 2.00 PBG 35 Castor Oil 0.21 Sodium Lauryl Ether Sulfate 0.24 Water 73.00 Carbomer 0.25 25 Triethanolamine 0.10 Propylene Glycol 5.00 Preservative 0.20 -17- CLAIMS: 1. An aerosol composition comprising a biliquid foam, an aqueous phase and a propelIant. 5 2. An aerosol composition as claimed in claim 1 wherein the biliquid foam incorporates an oil soluble functional material therein. 10 3. An aerosol composition as claimed in claim 2 wherein the oil soluble functional material is a fragrance, lubricant, vegetable oil, fuel, silicons, ester or a bioactive material. 15 4. An aerosol composition as claimed in any one of the preceding claims wherein the propellant is liquefied petroleum gas. 5. An aerosol composition as claimed in any one of the 20 preceding claims which comprises from 0.01 to 40% by weight of the biliquid foam, from 5 to 40% by weight of the propellant and from 20 to 95% by weight of water. 6. An aerosol ccmposition as claimed in any one of the 25 preceding claims wherein the aqueous phase includes therein one or more surfactants. 7 An aerosol compositon as claimed in claim a wherin the surfectant is a cationic surfactants, or additives. 30 8. An.aerosol composition as claimed in claim 7 wherein the cationic surfactant is a quaternary AMENDED SHEET WO 2004/041227 PCT/GB2003/004806 - 18 - ammonium compound or amine oxide, 9. An aerosol composition as claimed in any one of the preceding claims which is a polish, air 5 fresher, repellent, pre- or post shave preparation, shaving preparation or follicle softner. 10. A pressurized aerosol can comprising an aerosol 10 composition as defined in any one of the preceding claims. 11. A process for preparing an aerosol composition as defined in any one of claims 1 to .10 which 15 comprises adding the aqueous phase to a vessel, adding the biliquid foam to the vessel and mixing, and filling the aerosol can with the addition of a suitable propellat. An aerosol composition which prepared from a biliquid foam an aqueous phase and a propellant. The incor poration of an oil soluble functional material into the biliquid foam during the prparation of the aerosol composition enables this material to be more readily incorporated into the composition.

Full Text

The present invention relates to aerosol delivery
systems and, in particular, to aerosol delivery
5 system which are designed to reduce the amount of
surfactant Included therein.
Aerosol compositions are known in the art which
contain oil soluble functional materials such as
10 fragrances, silicones, esters and bio-active materials.
therein. In order to disperse the oil soluble
functional material into the aqueous phase of the
aerosol composition there is generally a requirement
to include in the composition from two to three times
15 by weight of the functional material of a solvent or
surfactant therein.
We have now found that incorporation of the oil
soluble functional material into a biliquid foam
20 enables this material to be readily dispersed
throughout the aqueous phase of the aerosol
composition without the use of excessive amounts of
solvents or surfactants, which may affect the material
and which may neutralize the effects of any
25 preservatives contained within the aerosol
composition.
Accordingly, the present invention provides an
aerosol composition which is prepared from a biliquid
30 foam, an aqueous phase and a propellant.
The invention also provides a pressurized aerosol
can comprising an aerosol composition, of the
invention.

WO 2004/042227 PCT/GB2003/004806
- 2 -
The invention also provides a process for
preparing an aerosol composition of the invention
which comprises adding the aqueous phase to a vessel,
adding the biliquid foam to the vessel and mixing and
5 filling an aerosol can with the addition of a suitable
propellent.
Biliquid foam are known in the art and are
described in the following literature references by
10 Sebba; "Biliquid foams", J. colloid and Interface
Science, 40 (1972) 468-474; and "The Behaviour of
Minute Oil Droplets Encapsulated in a Water Film"
Colloid Polymer Sciences, 257 (1979) 392-396.
15 US Patent No., 4486333 to Sebba describes a
particular method for the preparation of biliquid
foams by agiating a hydrogen bonded liquid containing
a soluble surfactant to produce a gas foam and
Intermittently adding to the gas foam a non-polar
20 liquid which is immiscible with the hydrogen bonded
liquid, the surfactant-containing hydrogen bonded
liquid being selected to provide a spreading
coefficient equal to or greater than zero.
25 The biliquid roam which is incorporated into the
aerosol compositions of the present invention
generally contains at least one oil soluble functional
material therein. Examples of the oil soluble
functional materials are fragrances, lubricants,
30 vegetable oils, fuels, silicones, esters and bio-
active materials.
The biliquid foam which is used in the present
invention will preferably comprise from 70 to 95% by

WO 2004/41227 PCT/GB2003/004806
- 3 -
weight of the oil phase, which may consist solely of
the oil soluble functional material, and 5 to 30% by
weight of the continuous phase, which is preferably an
aqueous phase. A surfactant to stabilise the biliquid
5 foam may also be included in an amount of from. 0 _ 1 to
3%, preferably 0.1 to 1% by weight based on the total
weight of the formulation. Suitable surfactants are,
for example, sodium lauryl ether sulphates,
polyethoxylated castor oil, ethoxylated oleyl alcohols
10 or polyethoxylated hydrogenated castor oils.
Propellents which are used in aerosol delivery
systems are well known in the art and will preferably
be liquified petroleum gas (LPG), Which is preferably
15 burane, optionally in admixture with propane. The
propellant will generally be present in an amount of
from 5 to 40% by weight.
The aerosol compositions of the present invention
20 will generally include the biliquid foam in an amount
of from o.1 to 10% by weight. The biliquid foam will
therefore generally provide the desired oil soluble
functional material in an amount of from 0. 07 to 9.5%
by weight.
25
The invention, includes within its scope an
aerosol composition which comprises from 0.01 to 40%
by weight of the biliquid foam, from 5 to. 40% weight
of the propellant and from 20 to 95% by weight of
30 water.
The aqueous phase of the asroeol composition may
include therein one or more surfactants or other
additives. The surfaatant may be chosen to prevent

WO 2004/041041227 PCT/GB2003/004806
- 4 -
interaction of the propellant with the biliquid foam.
Cationic surfactants are preferred, in particular
quaternary ammonium compounds or amine oxides.
Surfactants may also be choesn, to create an affinity
5 with the propellant.
The aerosol compositions of the present invention
may be packaged in cans which are well Known in the
art and generally are formed of aluminium or lacquered
10 or unlacquered tin plate or the like.
Methods of producing biliquict foam are described
in US-A-4486333 involving the preliminary formation of
a gas foam in order to provide a sufficiently large
15 surface area on which the biliquid foam can
subsequently be formed. It has been found that the
prior formation of a gas foam is not required to
manufacture a stable biliquid foam, provided that a
suitable stirring mechanism is provided in the
20 manufacturing vessel.
Such an apparatus comprises a tank provided with
a stirrer in which the stirrer blade breaks the
interface between the liquid and air and provides low
25 shear mixing throughout the whole of the volume of the
biliquid foam throughout the whole of the production
process. A delivery device is provided through which
the oil phase (non-polar liquid), which will comprise
the internal phase of the dispersion is delivered to
30 the tank. The design of the delivery device is such
that the rate of addition of the internal phase fluid
can be controlled and varied during the production
process. A feature of the production process is that
the internal (oil) phase ia added to the stirred

WO 2004/041227 PCT/GB2003/004806
- 5 -
aqueous phase slowly at first until sufficient
droplets have been formed to constitute a large,
additional surface area for the more rapid formation
of new droplets, At this point, the rate of addition
5 of the oil phase way be increased.
The production process consists of the following
steps:
10 1. The addition of one or more chosen
surfactants to one or other or both, phases
(as. previously determined by experiment) ,
2. The charging of the aqueous phase into the
bottom of a process vessel.
15 3. The incorporation of the stirrer into the
vessel so that it stirs the surface of the
aqueous phase.
4. Adjustment of the stirrer speed to a
previously determined level.
20 5, The slow addition of the internal phase
whilst continuing to stir at the prescribed
speed.
6. The speeding up of the rate of addition of
the oil phase once a prescribed amount
25 (usually between 5% and 10% of the total
amount to be added) 1 as been added.
The stirring rate and the rate of addition of the
oil phase are variables, the values of which depend
30 upon the detailed design of the manufacturing plant
(in particular, the ratio of tank diameter to impeller
diameter) r the physical-chemical properties of the oil
phase and the nature and concantrations of the choser,.
surfactants . These can all be pre-determined by

WO 2004/041227 PCT/GB2003/004806
- 6 -
laboratory or pilot plant experiment.
It will be understood by those skilled in the art
that other manufacturing methods for the biliquid foam
5 may be used, as appropriate.
The preparation of the biliquid foams proceeds
independently of the preparation of the final aerosol
compositions of the invention. The aerosol
10 compositions may be prepared by adding the aqueous
phase optionally including one or more surfactants
therein to a suitable vessel, adding the biliquid foam
thereto and mixing. The composition so prepared is
then filled into aerosol cans using techniques known
15 in the art. The. compositions are then pressurized in
the aerosol cans, with the addition of a suitable
propellant, using techniaques known in the art.
The aerosol compositions of the present invention
20 will generally possess one or more of the following
advantages:
- the elimination of the need for the use of
large amounts of solvents or surfactants and
25 volatile organic compounds.
- the potential to reduce skin irritation in
compositions which are to be applied to the
skin;
30
- the possibility to include in the
Composition oils which, would generally be
incomptible with one another;

WO 2004/041227 PCT/CB2003/004806
- 7 -
- the possibility of using lower levels of
fragrance components, whilst obtaining the
same level of fragrance impact.
5 - the possibility of using lower levels of
preservatives, whilst obtaining the same
level of preservation.
- better performing formulations which allow
10 dispensing using less propellant to achieve.
similar results.
The aerosol compositions of the invention are
preferably used as or in polishes, particularly
15 furniture polishes, air fresheners, fragrances/
moisturisers, sunscreens, shaving preparations, or
follicle softeners.
The aerosol compositions of the invention may
20 contain other components (in addition to the biliquid
foam aqueous phase and propellant) depending upon the
uses to which they are to be put. Thus, where the
aerosol compositions are to be used as polishes, the
compositions may additionally contain waxes, for
25 example vegetable waxes (for example, carnauba and
candelilla) , optionally combined with one or more
softeners, fillers and pigments. one or more alcohols
or other solvents may also be present.
30 Where the aerosal compositions are used. as
furniture polishes, these may additionally contain one
or more of silicone, red oil, lemon oil and petroleum
solvent; nail polishes generally comprise
nitrocellulose, optionally with amyl acetate solvent

WO 2004/041227 PCT/GB2003/004806
- 8 -
present.
Where the aerosol compositions are used as air
fresheners, a perfumed component (e.g. a free perfume)
5 will generally be present. In addition, such
compositions may comprise one or more of the group
comprising porosity modifiers, disintegrants, water-
swelling agents and colourants. Also present may be
inert fillers, hydroscopic agents. binders, coating
10 materials and moisture-providing agents,
Where the compositions are used as repellents,
these will generally comprise an active repellent
agent: such as citronella oil, dimethyl phthalate, n-
15 butylmesityl oxide oxalate and l-ethyl hexane-1,3-
diol. Actidione may be used as an active agent in
rodent repellents as may thiuram disulfide amino
complexes with trinitrobenzne and hexaohlorophene.
20 where the aerosol compositions are used as
shaving preparations, appropriate additional
components may be as described in Harry's
Cosmeticology, 7th Ed; J, B. wilkinson and R-. J.
Moore (editors), Chemical Publishers, New York, 1982,
25 pp. 126 - 189 .
Sunscreens will generally comprise either of both
of both a UV-A or UV-B filter. UV-A filters are
generally derivates of dibenzoylmethanef particularly
30 avobenzene (4- (1,1 -dimethylethyl) -4'-
methoxydibenzoylmethne, sold under the brand name
PARSOL 1789) . Preferably, each of avobenzone, octyl
salicylate and oxybenzoe is present. other
diahabenzoymethane derivatives known be UV-A filters

WO 2004/041227 PCT/GB2003/004806
- 9 -
are described in US Patent Nos. 4,387,089, 4,489,057
and 4,562,057, UV-B filters are generally
paramethoxycinnaic acid esters, such as 2-ethylhexyl
paramethoxycinncimate, generally known as octyl methoxy
5 cinnamate ar PARSOL MCX, octyl salicyiate and
oxybenzone-
Follicle softeners generally comprise one or more
of the following: surfactants, lubrictants, hunectants,
10 foaming agents, fragrances, fatty acids and bases.
The contents of all publications referred to
herein are hereby incorporated ay reference.
15 The present invention will be further described with
reference to the following Examples,
Examples 1
20 Preparation of biliquid foam
A biliquid to foam was prepared from the following
ingredients using the stirring mathod as described
above. The aqueous phase was introduced into a beaker
equipped with a stirrer, the diameter of which was
25 approximately 60% of the beaker diameter and the depth
sufficient to provide mixing throughout the body of
the biliquid foam once the oil addition was complete,
to provide law shear mixing. The fragrance and
surfactant were slowly added over a period of a few
30 minutes with Stirring continuing after completion of
the oil addition until the sample became homogeneous.
Oil Phase % w/w
Fragrance 8.9.1

WO 2004/041227 PCT/GB2003/004806
- 10 -
Castor oil/PoIyoxyethylene glycol 0.9
(35) adduct (Etocas 35 NF)
Aqueous Phase
5 Demin. Water 9.90
Sodium lauryl ether sulphate
(Standopol) 0.10
100.00
10 Preparation of Screening Aerosol Composition
An aerosol formulation was prepared from the
following ingredients:
% w/w
Biliquid foam 0.34
15 polyquaternium-11 (Gafquat 755N) 5.00
Isopentane 5.00
Water 89.66
100.00
20 The water was mixed with the polyquaternium-11
and the biliquid foam added. The isopentane was then
added to the mixture. The mixture demonstrated the
suitability of the invention for formulation as an
aerosol composition using a suitable propellant to
25 replace the isopentane.
Example 2
A screening aerosol formulation was prepared from
30 the following ingredients:
% w/w
Biliquid foam of Example 1 0.34
Polyquaterniunm-11 (Gafquat 755N) 0.10
Isopentane 5.00

WO 2004/041227 PCT/GB2003/004806
- 11 -
Water 94.56
200.00
The water was mixed with the polyguaternium-11
5 and the biliquid foam added. The isopentane was then
added to the mixture.
_Example_ 3
10 A screening aerosol formulation was prepared from
the following ingredients:
% w/w
Biliquid foam of Example 1 0.34
15 Polyquaternium-11 (Gafquat 755N) 0.05
Ispentane 5.00
Water 94.61
100 .00
20 The water was mixed with the polyquaternium-11
and the biliquid foam added. The isopentane was then
added to the mixture.
Example 4
25
A screening aerosol formulation was prepared from
the following ingredients,
% w/w
Biliquid foam of Example 1 0.34
30 Polyquaternium-7 (Mackernium 007) 0.10
Isopentane 5.00
Water 94.56
100.00

WO 2004/041227 PCT/GB2003/001806
- 12 -
The water was mixed with the polyquaternium-11
and the biliquid foam added. The isopentane wsa then
added to the mixture.
Example 5
5
A screening aerosol formulation was prepared from
the. following ingrdients:
% w/w
Biliquid foam of Example 1 0.34
10 Dicetyl Dimonium Chloride
(Proquat 868-P) 0.10
Isopentane 5.00
Water 94.56
100.00
15
The water was mixed with the polyquaternium-11
and the biliquid foam added. The isopentane was then
added to the mixture.
20 Example 5
A screening aerosol formulation was prepared from
the following ingredients:
% w/w
25 Biliquid foam of Example 1 0.34
Amine oxide (Ao-455) 0.10
Isopentane 5.00
Water 95.94
100.00
30
The water was mixed with the polyquaternium-11
and the biliquid foam added. The isopentane was then
edded to the mixture.

WO 2004/04l227 PCT/GB2003/00-1806
- 13 -
Example 7
A screening aerosol formulation was prepared from
the following ingredients:
5 % w/w
Biliquid foam of Example 1 0.34
Amine oxide (AO-455) 0.05
Isapentane 5.00
Water 94.51
10 100.00
The water was mixed with the polyquaternium-11
and the biliquid foam added. The isopsntane was then
added to the mixture.
15
Example B
A screening aerosol formulation was prepared from
the fallowing ingredients:
20 %w/w
Siliquid foam of Example 1 0.34
Vinyl caprolactam/PVP/Dimethyl-
aminomethyl mathacrylate copolymer 0.10
Isopentane 5.00
25 Water 94.56
100.00
The water was mixed with the polyquaternim-11
and the biliquid foam added. The isopentane was then
30 added to the mixture.

WO 2004/041227 PCT/GB2003/004806
- 14 -
Example _9
A screening aerosol formulation was prepared from
the fellowing ingredients:
5 % w/w
Biliquid foam 0.34 0.34
Dimethyl lauryl amine oxide 0.10
Isopentane 5.00
Water 94.56
10 100.00
The water was mixed with the polyqaternium-11
and the biliquid foam added. The isopentane was then
added to the mixture.
15
Example10
A screening aerosol formulation was prepared from
the following ingredients:
20 %w/w
Biliquid foam of example 1 0.34
Cocamidopropylamine oxide 0.10
Isopentane 5.00
Water 94.56
25 100.00
The water was mixed with the polyquaternium-11
and the biliquid foam added. The isopentane was then
added to the mixture.
30
In a similar, manner to the procedding examples,
further examples of aerosol compositions according to
the invention are prepared from the following
components :

WO 2004/041227 PCT/GB2003/004806
- 15 -
Example 11 : Furniture Polish
% w/w
5 Mineral Oil 21.02
Deodorized Mineral Spirits 1.20
Silicone 4.50
Laureth –4 0.27
Sodium Lauryl Ether Sulfate 0.30
10 Preservative 0.56
Water 71.76
Carbormer 0.56
Triethanolamine 0.34
15 Example 12: Fragrance / Moisturizer
%w/w
Water 55.264
Denatured Alcohol 20 .00
20 Glycerin 2.00
Polyacrylamide and c13-14 Isopal affin
and Laureth –7 0.60
Nylon-12 0.50
Titanium Dioxide 0.40
25 Glyceryl Trioctanoate 5.00
Isododecane 4.00
Silicone 6.00
Fragrance 6.00
PEG 25 Hydrogenated Castor Oil 0.106
30 PEG 25 Castor oil 0.106
Sodium Lauryl Ethar Sulfate 0.24

WO 2004/04227 PCT/GB2OO3/004806
- 16 -
Example 13: Air Freshener
% w/w
Water 97.98
5 Carbomer 0.60
Triethanolamine 0.30
Preservative 0.10
Fragrance 0.45
Laureth –4 0.27
10 sodium Lauryl Ether sulphate 0.30
Example 14: sunscreen
%w/w
15 Avobenzone 3.00
Octyl Salicylate 5.00
Oxybenzone 4.00
Dimethyhoxyl 2.6-Napthalate 5.00
sunflower oil 2.00
20 Cyclopentasiloxane 2.00
PBG 35 Castor Oil 0.21
Sodium Lauryl Ether Sulfate 0.24
Water 73.00
Carbomer 0.25
25 Triethanolamine 0.10
Propylene Glycol 5.00
Preservative 0.20

-17-
CLAIMS:
1. An aerosol composition comprising a biliquid foam, an
aqueous phase and a propelIant.
5 2. An aerosol composition as claimed in claim 1 wherein
the biliquid foam incorporates an oil soluble
functional material therein.
10 3. An aerosol composition as claimed in claim 2 wherein
the oil soluble functional material is a fragrance,
lubricant, vegetable oil, fuel, silicons, ester or a
bioactive material.
15 4. An aerosol composition as claimed in any one of the
preceding claims wherein the propellant is liquefied
petroleum gas.
5. An aerosol composition as claimed in any one of the
20 preceding claims which comprises from 0.01 to 40% by
weight of the biliquid foam, from 5 to 40% by weight of
the propellant and from 20 to 95% by weight of water.
6. An aerosol ccmposition as claimed in any one of the
25 preceding claims wherein the aqueous phase includes
therein one or more surfactants.
7 An aerosol compositon as claimed in claim a wherin
the surfectant is a cationic surfactants, or additives.
30
8. An.aerosol composition as claimed in claim 7 wherein
the cationic surfactant is a quaternary
AMENDED SHEET

WO 2004/041227 PCT/GB2003/004806
- 18 -
ammonium compound or amine oxide,
9. An aerosol composition as claimed in any one of
the preceding claims which is a polish, air
5 fresher, repellent, pre- or post shave
preparation, shaving preparation or follicle
softner.
10. A pressurized aerosol can comprising an aerosol
10 composition as defined in any one of the
preceding claims.
11. A process for preparing an aerosol composition as
defined in any one of claims 1 to .10 which
15 comprises adding the aqueous phase to a vessel,
adding the biliquid foam to the vessel and
mixing, and filling the aerosol can with the
addition of a suitable propellat.

An aerosol composition which prepared from a biliquid foam an aqueous phase and a propellant. The incor
poration of an oil soluble functional material into the biliquid foam during the prparation of the aerosol composition enables this
material to be more readily incorporated into the composition.

Documents:

« Previous Patent

Next Patent »

Patent Number

216846

Indian Patent Application Number

00885/KOLNP/2005

PG Journal Number

12/2008

Publication Date

21-Mar-2008

Grant Date

19-Mar-2008

Date of Filing

13-May-2005

Name of Patentee

DRUG DELIVERY SOLUTIONS LIMITED

Applicant Address

SUIT H13 THE THE LEATHERHEAD ENTERPRISE CE3NTERE RANDALIS ROAD LEATHERHEAD SURREY UK.

Inventors:

#	Inventor's Name	Inventor's Address
1	MERCURIO ANTIIONY FRED	577 DORCHESTER DRIVE, RIVERVALE, NEW JERSEY, NJ 07675, U.S.A
2	WILEELER DEREK ALFRED	C/O DISPERSE LIMITED, SURREY RESEARCH PARK, 40 ALAN TURING ROAD, SURREY RESEARCH PARK, GUILDFORD, SURREY GU2 6YF, GREAT BRITAIN.

PCT International Classification Number

A61K 7/15

PCT International Application Number

PCT/GB2003/04806

PCT International Filing date

2003-11-06

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1	10/288,590	2002-11-06	U.S.A.