Title of Invention	A WATERSTABLE GEL FOR DRESSING OF PELLETISED AQUATIC SPECIES FEED FOR TRANSPORTING AQUACULTURE FEED ADDITIVES
Abstract	A gel based formulation is developed with an objective of providing a neutral carrier for medication/other nutritional adjuncts to aquaculture species-as a "TOP DRESS" on feed. The novelty of the invention is that the gel dries up quickly after it is coated onto feed granules/pellets when exposed to air. This preparation does not allow the top dressed preparation to leach into water. Immonostimulants, probiotics and other medicaments can also be added to the gel.

Title of Invention

A WATERSTABLE GEL FOR DRESSING OF PELLETISED AQUATIC SPECIES FEED FOR TRANSPORTING AQUACULTURE FEED ADDITIVES

Abstract

A gel based formulation is developed with an objective of providing a neutral carrier for medication/other nutritional adjuncts to aquaculture species-as a "TOP DRESS" on feed. The novelty of the invention is that the gel dries up quickly after it is coated onto feed granules/pellets when exposed to air. This preparation does not allow the top dressed preparation to leach into water. Immonostimulants, probiotics and other medicaments can also be added to the gel.

Full Text	FIELD OF INVENTION This invention relates to a waterstable gel for dressing of pelletised aquatic species feed for transporting aquaculture feed additives. BACKGROOUND OF INVENTION Aquaculture species at times require medication/other healthcare treatments to be rendered to them as "TOP DRESS" on feed. A medium is required to administer the healthcare products to aquatic animals, successfully without undergoing leaching loss in water. Some species are quick feeders while some of them are slow feeders and they require "TOP DRESSED" materials to stay (on feed) in water for a longer period. All ingredients used are GRAS (Generally Regarded As Safe), easily digestible and have no side effects on the animal or humans who consume the fish/shrimp as food. It is known to use gels as a carrier for medicaments or other additives onto the feed pellets without considering its holding capacity. Several gels are currently available for aquaculture purposes with the following deficiencies. 1. After coating onto the feed granules/pellets do not dry up fast, 2. The medicaments or nutritional adjuncts added to the gel, while coating leaches out within 5-10 minutes when put in the aquaculture pond resulting in an economical loss to the farmer. 3. Leaching of medicaments into water causes depletion in dissolved oxygen level thereby increasing BOD and COD of water. OBJECTS OF THE INVENTION An object of this invention is to propose stable gels for transporting aquaculture additives as top dressing to aquatic species. Another object of this invention is to propose stable gels which efficiently transports medicaments or other additives into aquaculture species, which in turn results in maximum utilization of the added medicament or additive. Still another object of this invention is to propose stable gel which mixes up well with normal medicaments or nutritional adjuncts used for aquaculture. Yet another object of this invention is to propose stable gels which is easier to coat on feed pellets or granules. A further object of this invention is to propose stable gels which has an attractant in the gel to attract aquatic species to their feed pellets and thereby resulting in quicker and complete feed consumption. A still further object of this invention is to propose stable gels which dries up much faster in air and doesn't allow leaching of medicaments/feed supplements/probiotics and herbal extracts. STATEMENT OF INVENTION According to this invention there is provided a waterstable gel for dressing of pelletised aquatic species feed for transporting aquaculture additives characterized in that a solution in water of the compound selected from the carbomer group having 0.5% to 2,5% concentration, 0.1%-0.75% of a pharma-ceutically accepted cellulose and 0.25%-2.0% of natural flavour and the resultant composition having a pH value in the range of 4.5 to 8.5 and viscosity in the range of 10,000-25,000 cP. Further according to this invention there is provided a waterstable gel for dressing of pelletised aquatic species feed for transporting aquaculture additives characterized in that tff a solution in water of the compound selected from the carbomer group having 2.5% to 5% concentration, 2%-5% of a pharmaceutically accepted cellulose and L5%-2.5% of natural flavour and the resultant composition having a pH value in the range of 6.5 to 8.0 and viscosity in the range of 15,000-20,000 cP. DETAIL DESCRIPTION OF THE INVENTION The product is a highly water stable transparent and high viscous gel. It contains a high molecular weight binder with no roping and sticking which helps in easy blending with or without added feed supplements and medicaments. The polymer includes acrylic acid polymer/carboxyl vinyl polymer/carboxyl polymethylene Acritamer. The cellulose may be sodium carboxy methyl cellulose/methyl cellulose/ethyl cellulose/hydroxy propyl cellulose/hydroxy ethyl cellulose/hydroxy propyy methyl cellulose phthalate/hydroxy butyl cellulose. These ingredients are non toxic and listed in USP/NF/ Apart from this the gel is fortified with flavours, flavour enchancers and attractants which specifically attracts shrimps, prawn and fish. The addition of flavours ensure maximum uptake of feed, reduce pond fouling and mask medication and other less palatable raw materials, which can otherwise reduce intake. By maximum feed and medicaments consumption, wastage will be negligible and the bottom of the pond will be clear. The composition in water is present at a level of from about 10-80% by weight. The polymer is present at a level of from about 2.5-5%. The composition has a pH value of from about 6.5 to 8. The cellulose is present at the level of about 2-5%. The composition has a viscosity in the range of 10,000 to 25,000 cP. The composition contains Vitamin E-50% powder vrith Vitamin E in the range of 0.25%-2.5% and Selenium yeast/sodium selenite liquid - 50% of which selenium is in the range of 100 ppm-2000 ppm and probiotics in the range of 30-50 g/Kg of feed. The composition may have Vitamin-C (coated/non coated) in the range 0.5%-12%. Further the composition may contain herbal extracts like tuisi, Phyllanthus niruri, Tephrosia purpurea, Andrographis paniculata, Tinospora cordifolia, Eclipta alba & Piper longum in the range 0.05%-2.5%. The composition may also contain chlorohydroxyquinoline in the range 0.05%-2.5%. and Colistin sulphate USP in the range of 0.05%-!% and Doxycycline hydrochloride IP in the range 0.25%-2.5% DESCRIPTION The stability of this gel, which is used for top dressing of feed, could be enhanced by the use of preservatives. Sodium methyl/propyl paraben/sodium benzoate^ronopol at the level of 0.01% to 1% by weight. The pH value is adjusted if necessary to pH 4.5 to 8.5. The preferred range of pH can be adjusted with mild bases such astriethanol amine or ammonia. The composition of this invention is readily prepared by mixing the polymer and cellulose and slowly adding the flavour. Stirring should be done until the polymer and cellulose completely disperses. The pH is the adjusted if necessary to the desired range. The composition of this invention could be easily blended onto the fed with the added feed additive and medicaments. The composition is also stable over wide temperature range, having acceptable tolerance and is satisfactory from a physical and chemical stability standpoint. The primary application is on topdressing for the fish feed. NOVEL FEATURES OF THE INVENTION 1. The gel based formulation is compatible with normal medicaments and other feed additives. 2. It carries a natural attractant-which reaches sensory organs of aquatic species-thereby assuring complete consumption of feed. 3. It has a very good flow property-which helps in homogenous mixing of medicaments or other additives even with simple hand mixing. It forms a uniform coating on the feed pellets assuring even distribution of medicaments on feed. 4. It dries up faster, once coated on the feed pellets thereby avoiding use of conventional driers. A quick dyring character does not soak the pellet which otherwise reduces the water stability. 5. It holds the medicaments onto feed with negligible leaching effect, rendering maximum benefit to the aquatic species. ADVANTAGES OVER OTHER KNOWN ALTERNATIVES 1. Free flowing with excellent mixing characteristics. 2. Has a better drying capability under optimum conditions. 3. The dried gel matrix doesn't allow the value added content to leach out in water in aquaculture ponds, thereby resulting in the delivery of correct dosages desired by the aqua culturist. 4. Has an aquatic species attractant, which is a naturally derived product. Example 1: Acrylic acid polymer- 5% Carboxy Methyl Cellulose - 5% Methyl paraben - 0.75% Propyl paraben -1% Triethanolamine - to adjust the pH 6.5 to 8 Flavour-2.5% Water-Q.S to 100g The preservatives are mixed with the water. The complete dissolution is ensured untii the Acrylic acid polymer and Carboxy Methyl cellulose are mixed thoroughly. As a result a clear transparent gel is obtained and slowly flavour is added and mixed. pH of the gel is adjusted if necessary with triethanolamine and made up to the required weight by adding water and stirring thoroughly. The above gel of the said composition has a viscosity 15,000 cP at ambient condition. Example 2: Carboxy Vinyl Polymer - 5% Propyl methyl cellulose phthalate - 5% Bronopol -1% Flavour-2.5% Triethanolamine - to adj the pH 6.5 to 8 Water-Q.S to 100 g The preservative is mixed with the water. The complete dissolution is ensured until the Carboxy Vinyl polymer and Propyl Methyl cellulose are mixed thoroughly. As a result a dear transparent gel is obtained and slowly flavour is added and mixed. pH of the gel is adjusted if necessary with triethanolamine and made up to the required weight by adding water and stirring thoroughly. The above gel of the said composition has a viscosity 20,000 cP at ambient condition. Example 3: Acritamer-2.5% Bronopoi -1% Flavour - 2.5% Ammonia soln - to adj the pH 6.5 to 8 Water-Q.S to 100 g Bronopoi is mixed with water. Acritamer is then dispersed into it to get a clear gel. The flavour is then added slowly and mixed thoroughly. pH of the gel is adjusted with Ammonia solution and made up to the required weight by adding water and stirring thoroughly. The above gel of the said composition has a viscosity 18,000 cP at ambient condition. Example 4: Carboxy polymethylene Acritamer - 5% Hydroxy butyl cellulose - 5% Bronopoi -1% Flavour - 2,5% Tuisi extract ( or any other herbal extract) - 0.05% - 2.5% Triethanolamine - to adj the pH 6.5 to 8 Water - Q.S to 100 g Bronopoi is mixed with water. Carboxy Polymethylene Acritamer and Hydroxy butyl celiulose are then dispersed into it to get a clear gel. The flavour is then added slowly and mixed thoroughly. pH of the gel is adjusted with triethanolamine. Herbal extract is then added to the above gel and mixed thoroughly. Finally the whole is made up to the required weight by adding water and stirring thoroughly. The above gel of the said composition has a viscosity 22,000 cP at ambient condition. Example 5: Carboxy Vinyl Polymer - 5% Methyl Cellulose - 5% Benzoyl peroxide -1% Flavour-2.5% Vitamin E - 0.25% - 2.5% Selenium -100 ppm - 2000 ppm Ammonia soln - to adj the pH 6,5 to 8 Water-Q.S to 100 g Benzoyl peroxide is mixed with water. Carboxy Vinyl Polymer and Methyl Cellulose are then dispersed into it to get a clear gel. The flavour is then added slowly and mixed thoroughly, pH of the gel is adjusted with ammonia. A premix is prepared by mixing Vitamin E 50% powder and Selenium. This premix is then added to the above gel and mixed thoroughly. Finally the whole is made up to the required weight by adding water and stirring thoroughly. The above gel of the said composition has a viscosity 25,000 cP at ambient condition. Example 6: Polymer - 5% Cellulose - 5% Bronopol -1% Flavour - 2.5% Chioro hydroxy quinoline - 0.05% - 2.5% Triethanolamine - to adj the plH 6.5 to 8 Water-Q.S to 100 g Bronopol is mixed with water. Polymer and Cellulose are then dispersed into it to get a clear gel. The flavour is then added slowly and mixed thoroughly, pH of the gel is adjusted with triethanolamine. Chloro hydroxy quinoline is then added to the above ge! and mixed thoroughly. Finally the whole is made up to the required weight by adding water and stirring thoroughly. The above gel of the said composition has a viscosity 20,000 cP at ambient condition. Example 7: Acritamer 2.5% Ethyl Cellulose - 5% Imidurea -1% Flavour-2-5% Probiotics -in the range of 30 - 50 g/Kg of feed Monoethanoiamine - to adj the pH 6.5 to 8 Water-Q.S to 100 g Imidurea is mixed with water. Acritamer and Ethyl Cellulose are then dispersed into it to get a clear gel. The flavour is then added slowly and mixed thoroughly. pH of the gel is adjusted with monoethanoiamine. Required probiotics are then added to the above gel and mixed thoroughly. Finally the whole is made up to the required weight by adding water and stirring thoroughly. The above gel of the said composition has a viscosity 25,000 cP at ambient condition. Example 8 : Acrylic acid Polymer - 5% Hydroxy ethyl Cellulose - 5% Bronopol -1% Flavour-2-5% Vitamin C-0.5% ^12% Tnethanolamine - to adj the pH 6.5 to 8 Water-Q.S to 100 g Bronopol is mixed with water. Acrylic acid polymer and Hydroxy ethyl Cellulose are then dispersed into it to get a clear gel. The flavour is then added slowly and mixed thoroughly. pH of the gel is adjusted with tnethanolamine. Vitamin C is then added to the above gel and mixed thoroughly. Finally the whole is made up to the required weight by adding water and stirring thoroughly. The above gel of the said composition has a viscosity 20,000 cP at ambient condition. Example 9 : Carboxy Vinyl Polymer - 5% Hydroxy propyl Cellulose - 5% Bronopol -1% Flavour-2.5% Colistin sulphate USP- 0.05% -1% Doxycycllne hydrochloride IP - 0.25% - 2.5% Triethanolamine - to adj the pH 6.5 to 8 Water-Q.S to 100 g Bronopo! is mixed with water. Carboxy Vinyl Polymer and Hydroxy propyl cellulose are then dispersed into it to get a clear gel. The flavour is then added slowly and mixed thoroughly. pH of the gel is adjusted with triethanolamine, Colistin sulphate USPand Doxycycllne hydrochloride IP are then added to the above gel and mixed thoroughly. Finally the whole is made up to the required weight by adding water and stirring thoroughly. The above gel of the said composition has a viscosity 22,000 cP at ambient condition. Water stable property of the gels were acceptable after topdressing with feed and dispersed into the pond. GLOSSARY : GRAS : Generally Regarded As Safe BOD : Biological Oxygen Demand COD : Chemical Oxygen Demand IP : Indian Pharmacopoeia USP/NF : United States Pharmacopoeia / National Formulary ppm : parts per million cP : centipoise Q.S : Quantity Sufficient The flow chart relatinq to the process of preparation of the composition is shown in Fiq.l of the acccnipanvinq drawinq- WE CLAIM; L A waterstable gel for dressing of palletised aquatic species feed for transporting aquaculture additives characterized in that a solution in water of the compound selected from the carbomer group having 0.5% to 2.5% concentration, 0.1%-0.75% of a pharma-ceutically accepted cellulose and 0,25%-2,0% of natural flavour and the resultant composition having a pH value in the range of 4.5 to 8.5 and viscosity in the range of 10,000-25,000 cP. 2. A waterstable gel for dressing of pelletised aquatic species feed for transporting aquaculture additives characterized in that tff a solution in water of the compound selected from the carbomer group having 2.5% to 5% concentration, 2%-5% of a pharmaceutically accepted cellulose and 1.5%-2.5% of natural flavour and the resultant composition having a pH value in the range of 6,5 to 8.0 and viscosity in the range of 15,000-20,000 cP. 3. A composition as claimed in claim 1 or 2 wherein the said carbomer may be acrylic acid polymer/carboxyl vinyl polymer/ carbojQ^l poly methylene Acritamer. 4. A composition as claimed in claim 1 or 2 wherein the said cellulose may be sodium carbojq^ methyl cellulose/ethyl cellulose/ hydroxy propyl cellulose/ hydroxy ethyl cellulose/hydroxy propyl ethyl cellulose phthalate/hydroxy ethyl cellulose. 5. A composition as claimed in claim 1 or 2 wherein said composition in water is present at a level of 10-80% by weight. 6. A composition as claimed in claim 1 having a pH value of 6.5 to 8. 7. A composition as claimed in claim 1 or 2 comprising of Vitamin E-50% powder with Vitamin E in the range 0.25%-2.5% and Selenium yeast/Sodium selenite liquid-50% of which selenium is in the range of 100 ppm-2000 ppm. 8. A composition as claimed in claim 1 or 2 comprising of probiotics in the range of 30-50 g/Kg of feed. 9. A composition as claimed in claim 1 or 2 comprising of Vitamin C (coated/non coated) in the range of 0.5%-12%. 10. A composition as claimed in claim 1 or 2 comprising of herbal extracts like tulsi, Phyllanthus niruri, Tephrosia purpurea, Andrographis paniculata, Tinospora cordifolia, Eclipta alba 85 Piper longum in the range of 0.05%-2.5%. 11. A composition as claimed in claim 1 or 2 comprising of chlorohydroxyquinoline in the range of 0.05%-2.5%, 12. A composition as claimed in claim 1 or 2 comprising of Colistin sulphate USP in the range of 0,05%-1% and Doxycycline hydrochloride IP in the range of 0,25-2.5%. 13. A waterstable gel for dressing of pelletised aquatic species feed for transporting aquaculture additives substantially as herein described and illustrated.

Full Text

FIELD OF INVENTION
This invention relates to a waterstable gel for dressing of pelletised aquatic species feed for transporting aquaculture feed additives.
BACKGROOUND OF INVENTION
Aquaculture species at times require medication/other healthcare treatments to be rendered to them as "TOP DRESS" on feed. A medium is required to administer the healthcare products to aquatic animals, successfully without undergoing leaching loss in water. Some species are quick feeders while some of them are slow feeders and they require "TOP DRESSED" materials to stay (on feed) in water for a longer period. All ingredients used are GRAS (Generally Regarded As Safe), easily digestible and have no side effects on the animal or humans who consume the fish/shrimp as food.
It is known to use gels as a carrier for medicaments or other additives onto the feed pellets without considering its holding capacity.

Several gels are currently available for aquaculture purposes with the following deficiencies.
1. After coating onto the feed granules/pellets do not dry up fast,
2. The medicaments or nutritional adjuncts added to the gel, while coating leaches out within 5-10 minutes when put in the aquaculture pond resulting in an economical loss to the farmer.
3. Leaching of medicaments into water causes depletion in dissolved oxygen level thereby increasing BOD and COD of water.
OBJECTS OF THE INVENTION
An object of this invention is to propose stable gels for transporting aquaculture additives as top dressing to aquatic species.
Another object of this invention is to propose stable gels which efficiently transports medicaments or other additives into aquaculture species, which in turn results in maximum utilization of the added medicament or additive.
Still another object of this invention is to propose stable gel which mixes up well with normal medicaments or nutritional adjuncts used for aquaculture.

Yet another object of this invention is to propose stable gels which is easier to coat on feed pellets or granules.
A further object of this invention is to propose stable gels which has an attractant in the gel to attract aquatic species to their feed pellets and thereby resulting in quicker and complete feed consumption.
A still further object of this invention is to propose stable gels which dries up much faster in air and doesn't allow leaching of medicaments/feed supplements/probiotics and herbal extracts.
STATEMENT OF INVENTION
According to this invention there is provided a waterstable gel for dressing of pelletised aquatic species feed for transporting aquaculture additives characterized in that a solution in water of the compound selected from the carbomer group having 0.5% to 2,5% concentration, 0.1%-0.75% of a pharma-ceutically accepted cellulose and 0.25%-2.0% of natural flavour and the resultant composition having a pH value in the range of 4.5 to 8.5 and viscosity in the range of 10,000-25,000 cP.

Further according to this invention there is provided a waterstable gel for dressing of pelletised aquatic species feed for transporting aquaculture additives characterized in that tff a solution in water of the compound selected from the carbomer group having 2.5% to 5% concentration, 2%-5% of a pharmaceutically accepted cellulose and L5%-2.5% of natural flavour and the resultant composition having a pH value in the range of 6.5 to 8.0 and viscosity in the range of 15,000-20,000 cP.
DETAIL DESCRIPTION OF THE INVENTION
The product is a highly water stable transparent and high viscous gel. It contains a high molecular weight binder with no roping and sticking which helps in easy blending with or without added feed supplements and medicaments.
The polymer includes acrylic acid polymer/carboxyl vinyl polymer/carboxyl polymethylene Acritamer. The cellulose may be sodium carboxy methyl cellulose/methyl cellulose/ethyl cellulose/hydroxy propyl cellulose/hydroxy ethyl cellulose/hydroxy propyy methyl cellulose phthalate/hydroxy butyl cellulose. These ingredients are non toxic and listed in USP/NF/ Apart from this the gel is fortified with flavours, flavour enchancers and attractants which specifically attracts shrimps, prawn and fish. The addition of flavours ensure maximum uptake of feed, reduce pond fouling and mask medication and other less palatable raw materials, which can otherwise reduce intake. By maximum feed and medicaments consumption, wastage will be negligible and the bottom of the pond will be clear.

The composition in water is present at a level of from about 10-80% by weight. The polymer is present at a level of from about 2.5-5%. The composition has a pH value of from about 6.5 to 8. The cellulose is present at the level of about 2-5%. The composition has a viscosity in the range of 10,000 to 25,000 cP.
The composition contains Vitamin E-50% powder vrith Vitamin E in the range of 0.25%-2.5% and Selenium yeast/sodium selenite liquid - 50% of which selenium is in the range of 100 ppm-2000 ppm and probiotics in the range of 30-50 g/Kg of feed. The composition may have Vitamin-C (coated/non coated) in the range 0.5%-12%. Further the composition may contain herbal extracts like tuisi, Phyllanthus niruri, Tephrosia purpurea, Andrographis paniculata, Tinospora cordifolia, Eclipta alba & Piper longum in the range 0.05%-2.5%. The composition may also contain chlorohydroxyquinoline in the range 0.05%-2.5%. and Colistin sulphate USP in the range of 0.05%-!% and Doxycycline hydrochloride IP in the range 0.25%-2.5%
DESCRIPTION
The stability of this gel, which is used for top dressing of feed, could be enhanced by the use of preservatives. Sodium methyl/propyl paraben/sodium benzoate^ronopol at the level of 0.01% to 1% by weight. The pH value is adjusted if necessary to pH 4.5 to 8.5. The preferred range of pH can be adjusted with mild bases such astriethanol amine or ammonia.

The composition of this invention is readily prepared by mixing the polymer and cellulose and slowly adding the flavour. Stirring should be done until the polymer and cellulose completely disperses. The pH is the adjusted if necessary to the desired range.
The composition of this invention could be easily blended onto the fed with the added feed additive and medicaments. The composition is also stable over wide temperature range, having acceptable tolerance and is satisfactory from a physical and chemical stability standpoint. The primary application is on topdressing for the fish feed.

NOVEL FEATURES OF THE INVENTION
1. The gel based formulation is compatible with normal medicaments and other feed additives.
2. It carries a natural attractant-which reaches sensory organs of aquatic species-thereby assuring complete consumption of feed.
3.
It has a very good flow property-which helps in homogenous mixing of medicaments or other additives even with simple hand mixing. It forms a uniform coating on the feed pellets assuring even distribution of medicaments on feed.

4. It dries up faster, once coated on the feed pellets thereby avoiding use of conventional driers. A quick dyring character does not soak the pellet which otherwise reduces the water stability.
5. It holds the medicaments onto feed with negligible leaching effect, rendering maximum benefit to the aquatic species.
ADVANTAGES OVER OTHER KNOWN ALTERNATIVES
1. Free flowing with excellent mixing characteristics.
2. Has a better drying capability under optimum conditions.
3. The dried gel matrix doesn't allow the value added content to leach out in water in aquaculture ponds, thereby resulting in the delivery of correct dosages desired by the aqua culturist.
4. Has an aquatic species attractant, which is a naturally derived product.

Example 1: Acrylic acid polymer- 5%
Carboxy Methyl Cellulose - 5%
Methyl paraben - 0.75%
Propyl paraben -1%
Triethanolamine - to adjust the pH 6.5 to 8
Flavour-2.5%
Water-Q.S to 100g
The preservatives are mixed with the water. The complete dissolution is ensured untii the Acrylic acid polymer and Carboxy Methyl cellulose are mixed thoroughly. As a result a clear transparent gel is obtained and slowly flavour is added and mixed. pH of the gel is adjusted if necessary with triethanolamine and made up to the required weight by adding water and stirring thoroughly. The above gel of the said composition has a viscosity 15,000 cP at ambient condition.
Example 2:
Carboxy Vinyl Polymer - 5%
Propyl methyl cellulose phthalate - 5%
Bronopol -1%
Flavour-2.5%
Triethanolamine - to adj the pH 6.5 to 8
Water-Q.S to 100 g
The preservative is mixed with the water. The complete dissolution is ensured until the Carboxy Vinyl polymer and Propyl Methyl cellulose are mixed thoroughly. As a result a dear transparent gel is obtained and slowly flavour is added and mixed. pH of the gel is adjusted if necessary with triethanolamine and made up to the required weight by adding water and stirring thoroughly. The above gel of the said composition has a viscosity 20,000 cP at ambient condition.

Example 3:
Acritamer-2.5%
Bronopoi -1%
Flavour - 2.5%
Ammonia soln - to adj the pH 6.5 to 8
Water-Q.S to 100 g Bronopoi is mixed with water. Acritamer is then dispersed into it to get a clear gel. The flavour is then added slowly and mixed thoroughly. pH of the gel is adjusted with Ammonia solution and made up to the required weight by adding water and stirring thoroughly. The above gel of the said composition has a viscosity 18,000 cP at ambient condition.
Example 4:
Carboxy polymethylene Acritamer - 5%
Hydroxy butyl cellulose - 5%
Bronopoi -1%
Flavour - 2,5%
Tuisi extract ( or any other herbal extract) - 0.05% - 2.5%
Triethanolamine - to adj the pH 6.5 to 8
Water - Q.S to 100 g
Bronopoi is mixed with water. Carboxy Polymethylene Acritamer and Hydroxy butyl celiulose are then dispersed into it to get a clear gel. The flavour is then added slowly and mixed thoroughly. pH of the gel is adjusted with triethanolamine. Herbal extract is then added to the above gel and mixed thoroughly. Finally the whole is made up to the required weight by adding water and stirring thoroughly. The above gel of the said composition has a viscosity 22,000 cP at ambient condition.

Example 5:
Carboxy Vinyl Polymer - 5% Methyl Cellulose - 5% Benzoyl peroxide -1% Flavour-2.5% Vitamin E - 0.25% - 2.5% Selenium -100 ppm - 2000 ppm Ammonia soln - to adj the pH 6,5 to 8 Water-Q.S to 100 g
Benzoyl peroxide is mixed with water. Carboxy Vinyl Polymer and Methyl Cellulose are then dispersed into it to get a clear gel. The flavour is then added slowly and mixed thoroughly, pH of the gel is adjusted with ammonia. A premix is prepared by mixing Vitamin E 50% powder and Selenium. This premix is then added to the above gel and mixed thoroughly. Finally the whole is made up to the required weight by adding water and stirring thoroughly. The above gel of the said composition has a viscosity 25,000 cP at ambient condition.
Example 6:
Polymer - 5%
Cellulose - 5%
Bronopol -1%
Flavour - 2.5%
Chioro hydroxy quinoline - 0.05% - 2.5%
Triethanolamine - to adj the plH 6.5 to 8
Water-Q.S to 100 g
Bronopol is mixed with water. Polymer and Cellulose are then dispersed into it to get a clear gel. The flavour is then added slowly and mixed thoroughly, pH of the gel is adjusted with triethanolamine. Chloro hydroxy quinoline is then added to the above ge! and mixed thoroughly. Finally the whole is made up to the required weight by adding water and stirring thoroughly. The above gel of the said composition has a viscosity 20,000 cP at ambient condition.

Example 7:
Acritamer 2.5%
Ethyl Cellulose - 5% Imidurea -1% Flavour-2-5%
Probiotics -in the range of 30 - 50 g/Kg of feed
Monoethanoiamine - to adj the pH 6.5 to 8 Water-Q.S to 100 g
Imidurea is mixed with water. Acritamer and Ethyl Cellulose are then dispersed into it to get a clear gel. The flavour is then added slowly and mixed thoroughly. pH of the gel is adjusted with monoethanoiamine. Required probiotics are then added to the above gel and mixed thoroughly. Finally the whole is made up to the required weight by adding water and stirring thoroughly. The above gel of the said composition has a viscosity 25,000 cP at ambient condition.
Example 8 :
Acrylic acid Polymer - 5% Hydroxy ethyl Cellulose - 5% Bronopol -1% Flavour-2-5% Vitamin C-0.5% ^12% Tnethanolamine - to adj the pH 6.5 to 8 Water-Q.S to 100 g
Bronopol is mixed with water. Acrylic acid polymer and Hydroxy ethyl Cellulose are then dispersed into it to get a clear gel. The flavour is then added slowly and mixed thoroughly. pH of the gel is adjusted with tnethanolamine. Vitamin C is then added to the above gel and mixed thoroughly. Finally the whole is made up to the required weight by adding water and stirring thoroughly. The above gel of the said composition has a viscosity 20,000 cP at ambient condition.

Example 9 :
Carboxy Vinyl Polymer - 5% Hydroxy propyl Cellulose - 5% Bronopol -1% Flavour-2.5%
Colistin sulphate USP- 0.05% -1% Doxycycllne hydrochloride IP - 0.25% - 2.5% Triethanolamine - to adj the pH 6.5 to 8 Water-Q.S to 100 g
Bronopo! is mixed with water. Carboxy Vinyl Polymer and Hydroxy propyl cellulose are then dispersed into it to get a clear gel. The flavour is then added slowly and mixed thoroughly. pH of the gel is adjusted with triethanolamine, Colistin sulphate USPand Doxycycllne hydrochloride IP are then added to the above gel and mixed thoroughly. Finally the whole is made up to the required weight by adding water and stirring thoroughly. The above gel of the said composition has a viscosity 22,000 cP at ambient condition.
Water stable property of the gels were acceptable after topdressing with feed and dispersed into the pond.
GLOSSARY :
GRAS : Generally Regarded As Safe
BOD : Biological Oxygen Demand
COD : Chemical Oxygen Demand
IP : Indian Pharmacopoeia
USP/NF : United States Pharmacopoeia / National Formulary
ppm : parts per million
cP : centipoise
Q.S : Quantity Sufficient
The flow chart relatinq to the process of preparation of the composition is shown in Fiq.l of the acccnipanvinq drawinq-

WE CLAIM;
L A waterstable gel for dressing of palletised aquatic species feed for transporting aquaculture additives characterized in that a solution in water of the compound selected from the carbomer group having 0.5% to 2.5% concentration, 0.1%-0.75% of a pharma-ceutically accepted cellulose and 0,25%-2,0% of natural flavour and the resultant composition having a pH value in the range of 4.5 to 8.5 and viscosity in the range of 10,000-25,000 cP.
2. A waterstable gel for dressing of pelletised aquatic species feed for transporting aquaculture additives characterized in that tff a solution in water of the compound selected from the carbomer group having 2.5% to 5% concentration, 2%-5% of a pharmaceutically accepted cellulose and 1.5%-2.5% of natural flavour and the resultant composition having a pH value in the range of 6,5 to 8.0 and viscosity in the range of 15,000-20,000 cP.
3. A composition as claimed in claim 1 or 2 wherein the said carbomer may be acrylic acid polymer/carboxyl vinyl polymer/ carbojQ^l poly methylene Acritamer.
4. A composition as claimed in claim 1 or 2 wherein the said cellulose may be sodium carbojq^ methyl cellulose/ethyl cellulose/ hydroxy propyl cellulose/ hydroxy ethyl cellulose/hydroxy propyl ethyl cellulose phthalate/hydroxy ethyl cellulose.

5. A composition as claimed in claim 1 or 2 wherein said composition in water is present at a level of 10-80% by weight.
6. A composition as claimed in claim 1 having a pH value of 6.5 to 8.
7. A composition as claimed in claim 1 or 2 comprising of Vitamin E-50% powder with Vitamin E in the range 0.25%-2.5% and Selenium yeast/Sodium selenite liquid-50% of which selenium is in the range of 100 ppm-2000 ppm.
8. A composition as claimed in claim 1 or 2 comprising of probiotics in the range of 30-50 g/Kg of feed.
9. A composition as claimed in claim 1 or 2 comprising of Vitamin C (coated/non coated) in the range of 0.5%-12%.
10. A composition as claimed in claim 1 or 2 comprising of herbal extracts like tulsi, Phyllanthus niruri, Tephrosia purpurea, Andrographis paniculata, Tinospora cordifolia, Eclipta alba 85 Piper longum in the range of 0.05%-2.5%.

11. A composition as claimed in claim 1 or 2 comprising of
chlorohydroxyquinoline in the range of 0.05%-2.5%,
12. A composition as claimed in claim 1 or 2 comprising of Colistin
sulphate USP in the range of 0,05%-1% and Doxycycline
hydrochloride IP in the range of 0,25-2.5%.
13. A waterstable gel for dressing of pelletised aquatic species feed
for transporting aquaculture additives substantially as herein
described and illustrated.

Documents:

0445-che-2003 abstract-duplicate.pdf

0445-che-2003 claims-duplicate.pdf

0445-che-2003 description (complete)-duplicate.pdf

445-che-2003-abstract.pdf

445-che-2003-claims.pdf

445-che-2003-correspondnece-others.pdf

445-che-2003-correspondnece-po.pdf

445-che-2003-description(complete).pdf

445-che-2003-form 1.pdf

445-che-2003-form 18.pdf

445-che-2003-form 26.pdf

445-che-2003-form 3.pdf

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Patent Number

226318

Indian Patent Application Number

445/CHE/2003

PG Journal Number

02/2009

Publication Date

09-Jan-2009

Grant Date

17-Dec-2008

Date of Filing

02-Jun-2003

Name of Patentee

TETRAGON CHEMIE PVT. LTD

Applicant Address

IS-40, KHB INDUSTRIAL AREA, YELAHANKA NEW TOWN, BANGALORE,

Inventors:

#	Inventor's Name	Inventor's Address
1	DHRUVAKUMAR L	IS-40, KHB INDUSTRIAL AREA, YELAHANKA NEW TOWN, BANGALORE,
2	P M RADHAKRISHNA	IS-40, KHB INDUSTRIAL AREA, YELAHANKA NEW TOWN, BANGALORE,
3	VIJAYANAND	IS-40, KHB INDUSTRIAL AREA, YELAHANKA NEW TOWN, BANGALORE,
4	BHARAT TANDAN	IS-40, KHB INDUSTRIAL AREA, YELAHANKA NEW TOWN, BANGALORE,

PCT International Classification Number

A61K47/38

PCT International Application Number

N/A

PCT International Filing date

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1			NA