Title of Invention	A PHARMACEUTICAL COMPOSITION COMPRISING COMPOUND OF FORMULA I AND TAXANES
Abstract	The present invention provides compositions and method for the treatment of cancer in a subject wherein compounds of formula i as defined herein in combination with paclitaxel, taxotere or mosified taxane or taxoid analogs provide enhanced anticancer effects over the effects achieved with the induvidual compounds.

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^-I^.=~^7ZN-LS- DERIVATIVES IN COM=~NATiON WITH-TWB*3S BACKGROUND OF THE INVENTION Cancer is a disease for which many potentially effective treatments are available. However, due to the prevalence of cancers of various types and the serious effects it can have, more effective treatments, especially those with fewer adverse side effects than currently available forms of treatment, are needed.. This invention relates to pharmaceutical compositions useful in treating cancer in a mammal. The pharmaceutical compositions' of the present invention comprise two compounds: a first compound which is paclitsxel, taxotere or a modified taxane cr taxoid analog arid a second compound, which is s compound of Formula I: R1 R2 N-CV:X-C0-A-3-D-{S),-(F)--(G)o-K (I) Formula I is discussed in detail bslow. Some examples of compounds of Formula I firs specifically presented herein. For example, compounds of Formula I can be those in which ?.- and ?.: are each methyl cr ethyl; X is isopropyl, sec-butyl cr rert-butyl; s is 1; t and u are each 0; A is valyl, isoleucyl cr 2-tsrt-butylglycyl; S is N-methylvalyl, 1-isoleucyl or 2-tert-butylelycyl; D is thiazolidinyl-carbcr.yl, 3,4-dehydroprolyl cr prolyl; E is prolyl, -hi=2=lidinyl-4-oarbonyl, homoprolyl, hydrcxyprolyl cr 3,4-dehydroprolyl; and K is a substituted amino moiety having the formula R=-K-Rs, wherein R5 is hydrogen cr C-C^-alkcxy and Rfi is a monovalent radical such as (1;- or (2)- adamantyl; {CH2)v-phenyl with v-1; a,ff-dimethylbenzyl; a ci"ci2 linear or branched hydroxyalkyl group, such as -C[CH3)2-CH2-CH2-OH, also referred to as 3-hydroxy-l, 1-dimethylpropyl; a C3-CJ0 cycloalkyl group, such as bicyclo[3.3.0]octa-l-yl, 1-methylcyclopentyl or 1-methylcyclohexylf or a CJ-CJJ linear or branched alkyl group, such as -C(CH3)3, also referred to as tert-butyl; -C-CH2-CH3, also referred to as 1,1-dimethylpropyl; (CH3)2 -C(CH2-CH3) 2, also referred to as 1-methyl-l-ethylpropyl; CH3 -CH-C(CH3)3, also referred to as (S)- or (R)-l-methyl-2,2- CH3 dimethyl-propyl; -CH-CH{CH3)2, also referred to as (S)- or (R)-l-ethyl-2- C2HS methylpropyl; -CH-CH(CH3)2, also referred to as l-isopropyl-2-methyl-CH{CH3)2 propyl; or -C£CH3)2-CH(CH3)2, also referred to as 1, l-dimethyl-2- methylpropyl; -CH(CH3)2 , also referred to as isopropyl; -CH(CHj)CH2CH3, sec-butyl [ (S) or (R) ] ; or -CH{CH3)CH(CH3)2, also referred to as 1, 2-dimethylpropyl. Each compound is present in the pharmaceutical composition in an effective amount. The pharmaceutical composition can include one or more of each type of compound (e.g., one or more of the first type of compound, such as paclitaxel or paclitaxel and taxotere and one or more compounds of Formula I). This invention also relates to methods of treating cancer in a mammal in which the pharmaceutical compounds described herein are used. In the method of the present invention, the two compounds are administered in the pharmaceutical composition or as individual/separate compounds which are given sufficiently close in time to have the desired effect. It has been discovered that, surprisingly the combination of paclitaxel, taxotere or a modified taxane or taxoid analog as described herein and a compound having Formula I as described herein provides enhanced or therapeutically synergistic anticancer effects in vivo. For purposes of this invention, two drugs are considered therapeutically synergistic if a combination- regimen produces a_significantly better tumor cell kill than the best constituent when it is administered alone at optimal or maximum tolerated doses. Differences in tumor cell kill less than half a decade are not considered signficant. BRIEF DESCRIPTION OF THE DRAWINGS The Figure depicts compounds i-xvii, as examples of compounds of Formula I. DETAILED DESCRIPTION OF THE INVENTION The present invention relates to pharmaceutical compositions useful in treating cancer in a mammal. The pharmaceutical composition of the present invention comprises two compounds: a first compound which is paclitaxel, taxotere or a modified taxane or taxoid analog and a second compound of Formula I as further described below. Each compound is present in the pharmacuetical composition in an effective amount. One or more of each type of compound can be present in the pharmaceutical composition or administered in the present method. As used herein the term "an effective amount" refers to an amount sufficient to elicit the desired biological response. In the instant invention, the desired biological response is inhibition (partial or total) of formation of a tumor or a hematological malignancy, reversal of the development of a solid tumor or other malignancy or prevention or reduction of its further progression. PACLITAXEL, TAXOTERE OR A MODIFIED TAXANE OR TAXOID ANALOG Paclitaxel (Taxol®), which is one example of a first compound of the pharmaceutical composition, is a diterpene isolated from the bark of the Western (Pacific) yew, Taxus brevifolia and is representative of a class of therapeutic agent having a taxane ring system. The formula for paclitaxel is: Paclitaxel and its analogs have been produced by partial synthesis from 10-deacetylbaccatin III, a precursor obtained from yew needles and twigs, and by total synthesis. See Holton, et al., J. Am. Chem. Soc. 216:1597-1601 (1994) and Nicolaou, et al., Nature 367:630 (1994). Paclitaxel has been demonstrated to possess antineoplastic activity. More recently, it was shown that the antitumor activity of paclitaxel is due to a promotion of microtubule polymerization. See Kumar, N., J. Biol. Chem. 256:10435-10441 (1981); Rowinsky, et al., J. Natl. Cancer Inst. £2:1247-1259 (1990); and Schiff, et al.. Nature 277:655-667 (1379). Paclitaxel has now demonstrated efficacy in several human tumors in clinical trials. See McGuire et al., Ann. Int. Med. 112:237-279 (1989); Holmes, et al., J. Natl. Cancer Inst. S3-.1797-1805 (1991); Kohn et al. , J. Natl. Cancer Inst. 86:18-24 (1994); and Kohn, et al., American Society for Clinical Oncology 12 (1993). Paclitaxel is available from Bristol-Myers Squibb Company, New York, NY by the registered tradename Taxol®. The first compound in the pharmaceutical composition is typically paclitaxel (Taxol ®), taxotere or a modified taxane or taxoid analog. The modified taxane or taxoid analogs are those compounds having a taxane ring bearing modified side chains. A number of these analogs have improved properties, such as greater water solubility and stability than that of naturally occurring paclitaxel. For example, RPR109881 is a new oral and iv active taxoid analog under development by Rhone-Foulenc Rhorer and currently in Phase I Clinical Trials. These analogs are known to those of skill in the art and are disclosed, for example, in U.S. Patent Nos. 5,278,324; 5,272,171; 5,254,580; 5,250,683; 5,248,796; and 5,227,400, the disclosures of which are incorporated herein by reference. Taxotere can be prepared by the method in WO 93/18210, the disclosure of which is incorporated herein by reference. In particular embodiments, tiie first compound in the pharmaceutical composition is paclitaxel or taxotere. COMPOUNDS OF FORMULA. 1 A number of short peptides with significant activity as inhibitors of cell growth have been isolated from the Indian Ocean sea hare Dolabella auricularia (Bai, et al., Bivchem. Pharmacology, 40: 1859-18G4 (1990); Beckwith et PA . , J. Natl. Cancer Inst., 85: 483-488 (1993) and references cited therein). These include Dolastatins 1-10 (U.S. Patent No. 4,616,444, issued to Pettit et al.) and Dolastatin-15 {European Patent Application No. 398558) . Dolastatin-15, for example, markedly inhibits the growth of the National Cancer Institute's P3B8 lymphocytic leukemia cell line, a strong predictor of efficacy against various types of human malignancies. This compound, however, is present only in trace quantities in the sea hare and is difficult to isolate, expensive to synthesize and suffers from poor aqueous solubility. The compounds of Formula I are derivatives of Dolastatin-15, which overcome the above-mentioned disadvantages of Dolastatin-15 while retaining antineoplastic actii'ity or exhibiting greater antineoplastic activity than the natural product. The Dolastatin-15 derivatives of Formula I, which are employed in combination with paclitaxel, taxotere or a modified taxane or taxoid analog in the present invention, can be synthesized, as described herein and in related copending application U. S.S.N. 06/472,453, filed June 7, 1995, the teachings of which are incorporated herein in their entirety. The Dolastatin-15 derivatives of Jcrmula I generally comprise L-amino acids, but they can also contain one or more D-amino acids, as described in related copending application U.S.S.N. OB/472,453 filed on June 7, 1995. Th compounds of Formula I can also be present as salts with physiologically-compatible acids, such as, but not .limited to, hydrochloric acid, citric acid, tartaric acid, lactic acid, phosphoric acid, methanesulfonic acid, acetic acid, formic acid, maleic acid, fumaric acid, malic acid, succinic acid, malonic acid, sulfuric acid, L-glutamic acid, L-aspartic acid, pyruvic acid, mucic acid, benzoic acid, glucuronic acid, oxalic acid, ascorbic acid and acetylglycine. For purposes of the present invention, the term "monovalent radical" is intended to mean an electrically neutral molecular fragment capable of forming one covalent bond v.-ith a second neutral molecular fragment. Monovalent radicals include the hydrogen atom, alkyl groups (e.g. methyl, ethyl, propyl and tert-butyl groups), cycloalkyl groups, hydroxy alkyl groups, adamantyl groups, halogen atoms (e.g. fluorine, chlorine and bromine atoms), aryl groups (e.g. phenyl, benzyl and naphthyl groups) and alkoxy groups (e.g. methoxy and ethoxy groups). Two monovalent radicals on adjacent sigma-bonded atoms can also form a pi bond between the adjacent atoms. Two monovalent radicals may also be linked together, for example, by a polymethylene unit to form a cyclic structure. For example, the unit -N More specifically, for the compounds of Formula I: R1 is alkyl, such as Cj-C3; cycloalkyl, such as cyclopropyl; alkylsulfonyl, such as Cx-C3; fluoroalkyl, such as fluoroethyl, difluoroethyl, f luoroisopropyl,- aminosulf onyl which may be substituted by alkyl, such as methyl; R2 is hydrogen; alkyl, such as CJ-CJ; fluoroalkyl, such as fluoroethyl, difluoroethyl, fluoroisopropyl; cycloalkyl, such as cyclopropyl; R1-N-R2 together may be a pyrrolidino or piperidino residue; A is a valyl, isoleucyl, leucyl, allo-isoleucyl, 2,2-dimethylglycyl, 2-cyclopropylglyCyl, 2- cycloprntylglycyl, 3-tert-butylalanyl, 2-tert-butylglycyl, 3-cyclohexylalanyl, 2-ethylglycyl, 2-cyclohexylglycyl, norleucyl or norvalyl residue; is a N-alkyl-valyl, -norvalyl, -leucyl, -isoleucyl, -2 -tert-butylglycyl, -3 -tert-butylalanyl, -2-ethylglycyl, - 2 -cyclopropylglycyl, -2-cyclopentylglycyl, norleucyl or -2-cyclohexylglycyl residue where N-alkyl is preferably N-methyl or N-ethyl; is a prolyl, homoprolyl, hydroxyprolyl, 3,4-dehydroprolyl, 4-fluoroprolyl, 3-methylprolyl, 4-methylprolyl, 5-methylprolyl, azetidine-2-carbonyl, 3 , 3 -dimethylprolyl, 4,4 -dif luoroprolyl, oxazolidine-4-carbonyl or thiazolidine-4-carbonyl residue; is a prolyl, homoprolyl, hydroxyprolyl, 3,4-dehydroprolyl, 4-fluoroprolyl, 3-methylprolyl, 4 -methylprolyl, 5-methylprolyl, azetidine-2-carbonyl, 3 , 3-dimethylprolyl, 4,4-difluoroprolyl, oxazolidine-4-carbonyl or thiazolidine-4-carbonyl residue; are independently selected from the group consisting of prolyl, homoprolyl, hydroxyprolyl, thiazolidinyl-4-carbonyl, 1-aminopentyl-l-carbonyl, valyl, 2-tert-butylglycyl, isoleucyl, leucyl, 3-cyclohexylalanyl, phenylalanyl, N-methylphenylalanyl, tetrahydrosi.oquinolyl-2-histidyl, l-aminoindyl-1-carbonyl, 3-pyridylalanyl, 2-cyclohexylglycyl, norleucyl, norvalyl, neopentylglycyl, trytophanyl, glycyl, 2,2-dimethylglycyl alanyl, G-alanyl and 3-naphthy]alanyl residues; X is hydrogen, alkyl (such as Cj-C5) , cycloalkyl (such as C3-C7), -CH2-cyclohexyl or arylalkyl (such as benzyl or phenethyl); s, t and u are independently 0 or 1; and K is hydroxy, alkoxy (such as Cj_-C4) , phenoxy, benzyloxy or a substituted or unsubstituted amino moiety. In addition, the compounds of Formula I can be present as a salt thereof with physiologically tolerated acids. One subclass of compounds of this invention includes compounds of Formula I wherein R1-N-R2 is a pyrrolidinyl or piperidinyl residue. Another subclass of compounds of this invention includes compounds of Formula I wherein K is an amino noiety of the formula R5-N-R6, wherein: Rs is hydrogen, or hydroxy, or C1.1 alkoxy, or benzyloxy, or phenyloxy or C^^ linear or branched hydroxyalkyl, such as. 3-hydroxy-l, 1-dimethylpropyl, or Cj__7 linear or branched alkyl {which may be substituted by one or more fluoro atoms), or C3.10-cycloalkyl, such as, bicyclo[3.3.0]octa-lyl, 1-methylcyclopentyl or 1-methylcylcohexyl; or benzyl (which may be substituted by up to three substituents which may independently be CF3, nitro, Cj_.7 alkylsulfonyl, Cj_.4 alkoxy, phenoxy, benzoxy, halogen, C^-alkyl, cyano, hydroxy, N(CH3)2, COOMe, COOEt, COOiPr, or COONH2) ; ^e is hydrogen, or C1.12 linear or branched alkyl (which may be substituted by one or more fluoro atoms), or C1.l2 linear or branched hydroxyalkyl, such as 3-hydroxy-1,1-dimethylpropyl, or C3_J0-cycloalkyl, such as bicyclo[3.3.Ojocta-1-yl, or 1-methylcyclopentyl or 1-methylcyclohexyl; or - (CH2)V-Cj.7- cycloalkyl (v=0,i,2, or 3), or norephedryl, or norpseudoephedryl, or quinolyl, or pyrazyl, or -CH2-benzimidazolyl, or (1) -adamantyl, or (2)-adamantyl- -CH2-adamantyl, or alpha-methyl-benzyl, or alpha-dimethylbenzyl, or -(CH2) v-phenyl (v=0,l,2, or 3; which may be substituted by up to two substituents which may independently be CF3, nitro, C^,, alkylsulfonyl, Cl. This subclass includes compounds of Formula I wherein s, t and u are independently 0 or 1; Rl, R2 and X are lower alkyl, A is a lower alkyl amino acid, B is a N-loweralkylated lower alkyl amino acid; D,E,F,G and K are as previously defined. With the foregoing in mind, three sets of such compounds can thus be depicted by the following formulas II, III, and IV: R1R2N-CXH-CO-A-B-Pro-Pro-F-G-K II ' R^N-CXH-CO-A-B-Pro-Pro-F-K III R1R3H-CXH-CO-A-B-Pro-Pro-K IV -CHR7-5-membered heteroaryl may, for example, be represented by one of the following residues: -NR5CHR7-5-membered heteroaryl may, for example, be epresented by the following residues: 5-me^ibered heteroaryl may, for example, be represented by the following residues: In another subclass of compounds of this invention Rs-N-R* together may form structures selected from the group consisting of: Still another subclass of compounds of this invention includes, for example, compounds of Formula I wherein s, t and u are 1 and K is a hydroxy, alkoxy, phenoxy or benzyloxy moiety. Yet another subclass of compounds of this invention includes, for example, compounds of Formula I wherein s and t are 1, u is o and K is a hydroxy, alkoxy, phenoxy or benzyloxy moiety. Another subclass of compounds of this invention includes, for example, compounds of Formula I wherein s is 1, t and u are 0 and K is a hydroxy, alkoxy, phenoxy or benzyloxy moiety. In particular embodiments, the second compound in the pharmaceutical composition of the invention is a compound of Formula I in which R1 and R2 are each methyl or ethyl; X is isopropyl, sec-butyl or tert-butyl; s is 1; t and u are each 0; A is valyl, isoleucyl or 2-tert-butylglycyl; B is K-methylvalyl, 1-isoleucyl or -2-tert-butylglycyl; D is prolyl, thi.azolidinyl-4-carbonyl or 3,4 dehydroprolyl; E is prolyl, thiazolidinyl- 4-carbonyl, homoprolyl, 3,4-dehydroprolyl or hydroxyprolyl; and K is a substituted or unsubstituted amino moiety having the formula RS-N-RG. In a further embodiment, the second compound in the pharmaceutical composition is a compound of Formula I in which R1 3nd R2 are each methyl or ethyl; X is isopropyl, cec-butyl or tert-butyl; s is 1; t and u are each 0; A is valyl, isoleucyl or 2-tert-butylglycyl; B is N-methylvalyl, 1-isoleucyl or 2-tertbutylglycyl; D is prolyl, thiazolidinyl~4-carbonyl, or 3,4-dehydroprolyl; E is prolyl, thiazolidinyl-4-carbonyl, homoprolyl, 3,4-cehydroprolyl or hydroxyprolyl; and K is a substituted amino moiety having the formula R5-N-RG wherein R5 is hydrogen or C1-C hydroxyalkyl group represented, for example, by the following monovalent radicals: -C(CHa)a-CH2-CHa-OH, also referred to as 3-hydroxy-l, l- dimethylpropyl; -C(CH3)3, also referred to as tert-butyl; -C-CH2-CH,( also referred to as 1,1-dimethyl propyl; (CH3)2 -9(CH2-CHj),, also referred to as 1-methyl-l-ethyl propyl; CH3 -9H-C(CH3)3, also referred to as (S) - or (R) -l-methyl-2,2-CH3 dimethyl propyl; -CH-CH(CH3J2, also referred to as (£)- or (RJ-l-ethyl-2-C-Hs methyl propyl; -CH-CH(CH3)a, also referred to as l-isopropyl-2-methyl CH(CH3)2' butyl; or -C(CH3) 2-CH(CH3) z, also referred to as 1, l-dimethyl-2-methyl propyl -CH(CH3)2, also referred to as isopropyl -CZ(CH3)C?iiCH1, also referred to as sec-butyl, (S) - or (R)- -CH(CK3)CH[CH3)2, also referred to as 1,2-dimethylpropyl. In another embodiment, the second compound in the pharmaceutical composition of the invention is a compound of Formula I in which R1 and R3 are each methyl or ethyl; X is isopropyl, sec-butyl or tert-butyl; s is 1; t and u are each 0; A is valyl, isoleucyl or 2-tert-butylglycyl; B is K-methylvalyl, l-isoleucyl or 2-tert-butylglycyl; D is prolyl, thiazolidinyl-4 -carbonyl, 3,4-dehydroprolyl; E is prolyl, thiazolidinyl-4-carbonyl, homoprolyl, 3,4-dehydroprolyl or hydroxyprolyl; and K is a substituted amino moiety having the formula R5-N-R6 wherein R5 is hydrogen or C1-CA alkoxy and RG is a monovalent radical such as a C3-C10 cycloalkyl group {e.g. cyclobutyl, cyclopentyl, cyclohexyl, or 1-methylcyclopentyl, or 1- methylcyclohexyl or bicyclo[3.3.0]octa-1-yl); a (1) - or (2) -adamantyl group; (CH3) v-phenyl with v*l or In a further embodiment, the second compound in the pharmaceutical composition of the invention is a compound of Formula T in which R1 and R2 are each methyl; X is isopropyl; s is 1; t and u are each 0; A is valyl; B is N-methylvalyl; D is prolyl; E is prolyl; and K is a substituted amino moiety having- the formula Rs-N-R6 wherein R5 is benzyl and RG is hydrogen. This compound corresponds to compound (xvii) depicted in the Figure. The results of the use of compound (xvii) of Formula I, in combination with paclitaxel are presented in Tables 1-4. The pharmaceutical compositions of the present invention may optionally contain a pharmaceutical^ acceptable carrier. Pharmaceutically acceptable carriers are well known to those who are skilled in the art. The choice of a carrier will be determined in part by the particular compounds in the combination, as well as by the particular method used to administer the pharmaceutical composition. Accordingly, there is a wide variety of suitable formulations of the pharmaceutical compositions of the present invention. For example, paclitaxel (Taxol4) is available as a sterile nonpyrogenic solution which includes polyoxyethylated castor oil (Cremophor® EL) and dehydrated alcohol, USP. In another aspect, the present invention comprises a method for partially or totally inhibiting formation of, or otherwise treating (e.g., reversing or inhibiting the further development of) solid tumors (e.g., tumors of the lui-q, breast, colon, prostate, bladder, rectum, or endometrium) or hematological malignancies (e.g., leukemias, lymphomas} in a mammal, for example, a human, by administering to the mammal an effective amount of a first compound which is paclitaxel, taxotere or a modified taxane or taxoid analog and administering an effective amount of a second compound, which is a compound of Formula I. The two compounds are administered in combination according to the invention. The term in combination in this context means that the drugs are given either simultaneously or sequentially. If given sequentially, one of the two compounds is usually detectable in the serum of the subject at the onset of administration of the other compound. In one embodiment, a compound of Formula I is administered first, followed by administration of the above described first compound, such as paclitaxel. In a specific embodiment, paclitaxel is administered about one hour after administration of a compound of Formula I. Alternatively, the first compound and the second compound can be administered simultaneously, or the first compound could be administered first, followed by administration of a second compound, which is a compound of Formula I. The first and the second compounds nay be administered alone or with a pharmaceutically accepted carrier or diluent appropriate for the desired route of administration. Administration can be by any of the means which are conventional for pharmaceutical, preferably oncological, agents, including oral and parenteral means such as subcutaneously, intravenously, intramuscularly, ir.traperitoneally, nasally or rectally. Such pharmaceutical compositions may also contain other therapeutically active ingredients. The dosage administered to the mammal, such as a human, includes a combination of an effective amount of a compound of Formula I and an effective amount of paclitaxel, taxotere or modified taxane or taxoid analog, as described herein. For a particular condition or method of treatment, the dosage can be determined empirically, using known methods, and will depend upon factors such as the biological activity, mechanism of action, cross resistance, overlapping toxicity and toxicity profile of the particular compounds employed; the means of =dministration; the age, health and body weight of the ecipient; the nature and extent of the symptoms; the requency of treatment; the administration of other herapies; and the effect desired. A typical daily dose of the compounds of Formula I ;ill be from about 5 to about 250 milligrams per kilogram >f body weight by oral administration and from about 1 to ibout 100 milligrams per kilogram of body weight by parenteral administration. A typical daily dose of saclitaxel, taxotere or a modified taxane or taxoid analog ■■■ill generally be from 5 to about 250 milligrams per cilogram. The first and the second compounds of the present invention can be administered in conventional solid or liquid pharmaceutical administration forms, for example, jncoated or (film)coated tablets, capsules, powders, granules, suppositories or solutions. These are produced in a conventional manner. The active substances can for this purpose be processed with conventional pharmaceutical aids such as tablet binders, fillers, preservatives, tablet disintegrants, flow regulators, plasticizers, wetting agents, dispersants, emulsifiers, solvents, sustained release compositions, antioxidants and/or propellant gases (cf. H. Sucker et si.; Pharmazeutische Technologie, Thieme-Verlag, Stuttgart, 1978). The administration forms obtained in this way typically contain from about 1 to about 90% by weight of the active substance. The compounds of Formula I are described in detail above. In a particular embodiment, the method of the invention uses a compound of Formula I in which R1 and H3 are each methy] or ethyl; X is isopropyl, sec-butyl or tert-butyl; s is 1; t and u are each 0; A is valyl, isolsucyl cr 2-tert~butylglycyl; B is N-methylvalyl, i- isoleucyl or 2-tert-butylglycyl; D is prolyl, thiazolidinyl-4-carbonyl or 3,4-dehydroprolyl; E is prolyl, thiazolidinyl-4-carbonyl, homoprolyl, 3,4-dehydroprolyl or hydroxyprolyl; and K is a substituted or unsubstituted amino moiety having the formula Rs-N-Rs. In a further embodiment, the method of the invention uses a compound of Formula I in which R1 and R2 are each methyl or ethyl ; X is isopropyl, sec-butyl or tert-butyl; s is 1 ,* t and u are each 0; A is valyl, isoleucyl or 2-tert-butylglycyl; B is N-methylvalyl, 1-isoleucyl or 2-tert-butylglycyl; D is prolyl, thiazolidinyl-4-carbonyl or 3,4-dehydroprolyl; E is prolyl, thiazolidinyl-4-carbonyl, homoprolyl, 3,4-dehydroprolyl or hydroxyprolyl; and K is a substituted amino moiety having the formula R5-N-Rs wherein ?.' is hydrogen or Ct-C4 alkoxy and R6 is a Cj-C12 linear or branched alkyl group or Cj^-C^ linear or branched hydroxyalkyl group represented, for example, by the following monovalent radicals: -C(CH3)2-CH2-CH2-OH, also referred to as 3 -hydroxy-1, l- dimethylpropyl; -C(CH3)3, also referred to as tert-butyl; -C-CH2-CH3, also referred to as 1,1-dimethyl propyl; tCH3}2 -C (CH2-CH3) 2, also referred to as 1-methyl-l-ethyl propyl; CH3 ■■CH-CiCH^}^, also referred to as (S) - or (R) - 1-methyl-2 , 2- CH3 dimethyl propyl; -CH-CH(CH3)2r also referred to as (S)- or (R)-l-ethyl-2-CH2HS methyl propyl; -CH-CH{CH3) 2> also referred to as l-isopropyl-2-metbyl CH(CH3)2 butyl; or -C(CH3)2~CH(CH3)2, also referred to as 1, l-dimethyl-2-methyl propyl -CH(CH3}2, also referred to as isopropyl -CH(CH3)CH2CH3, also referred to as sec-butyl, (S) - or (R)--CH(CH3)CH(CH3Jj, also referred to as 1,2-dimethylpropyl. In another embodiment, the method of the invention uses a compound of Formula I in which R1 and R2 are each methyl or ethyl; X is isopropyl, eec-butyl or tert-butyl; s is 2; t and u are each 0; A is valyl, isoleucyl or 2-tert-butylglycyl; B is N-methylvalyl, 1-isoleucyl or 2-tert-butylglycyl; D is prolyl, thiazolidinyl-4-carbonyl, 3,4-dehydroprolyl; E is prolyl, thiazolidinyl-4-carbonyl, homoprolyl, 3,&-dehydroprolyl or hydroxyprolyl ,* and K is a substituted amino moiety having the formula Rs-N-Rs wherein R5 is hydrogen or Cx-Ck alkoxy and R6 is a monovalent radical such as a C3-Cl0 cycloalkyl group (e.g. cyclobutyl, cyclopentyl, cyclohexyl, 1-methylcyclopentyl, 1-meiihylcyclohexyl or bicyclo[3 . 3 . Ojocta-1-yl) ; a (1)- or (2)-adamantyl group; (CH2) v-phenyl with v*i or ct, In a further embodiment, the method of the invention uses a compound of Formula I in which R1 and R2 are each nethyl; X is isopropyl; s is 1; t and u are each 0; A is valyl; 8 is W-methyl valyl; D is prolyl; E is prolyl; and K is a substituted amino moiety having the formula RE-N-Re wherein Rs is benzyl and RG is hydrogen. This compound corresponds to compound (xvii) depicted in the Figure. The results of the use of compound (xvii) of Formula I, in combination with paclitaxel are presented in Tables 1-4. SYKTHETIC METHODS The compounds of Formula I can be prepared by known methods of peptide synthesis such as those described herein and, in U.S. Patent Application Serial No. 08/470,453 filed June 7, 1995, the teachings of which are incorporated herein by reference. The peptides can be assembled sequentially from individual amino acids or by linking suitable small peptide fragments. In sequential assembly, the peptide chain is extended stepwise, starting at the C-terminus, by one amino acid per step. In fragment coupling, fragments of different lengths can be linked together, ; and the fragments can also be obtained by sequential assembly from amino acids or by fragment coupling of still shorter peptides. In both sequential assembly and fragment coupling it is necessary to link the units by forming an amide linkage, which can be accomplished via a variety of enzymatic and chemical methods. The methods described herein for formation of peptidic amide linkages, are also suitable for the formation of non-peptidic amide linkages. Chemical methods for forming the amide linkage are described in detail in standard references on peptide chemistry, including Muller, Methoden der oraanischen Chemie Vol. XV/2, 1-364, Thieme Verlag, Stuttgart, {1974); Stewart and Young, Solid Phase Peptide Synthesis. 31-34 and 71-82, Pierce Chemical Company, Rockford, IL (1984); Bodanszky et al., Peptide Synthesis. 65-128, John Wiley & Sons, New York, (1976); Practice of Peptide Svnthesisr H. Bodansky, A. Bodansky, Springer-Verlag, 1994 and other standard works in peptide chemistry. Preferred methods include the azide method, the symmetric and mixed anhydride method, the use of in situ generated or preformed active esters, the use of urethane protected N-carboxy anhydrides of amino acids and the formation of the amide linkage using coupling reagents, such as dicyclohexylcarbodiimide (DCC), diisopropylcarbodiimide (DIC), l-ethoxycarbonyl-2-ethoxy-l,2-dihydroquinoline (EEDQ), pivaloyl chloride, l-ethyl-3- (3-dimethylaminopropyl)carbodiimide hydrochloride (EDCI), n-propane-phosphonic anhydride (PPA), N,N-bis {2-oxo-3-oxazolidinyl)amido phosphoryl chloride (B0P-C1) bromo-tris-pyrrolidinophosphonium hexafluorophosphate (PyBrop), diphenylphosphoryl azide (DPPA), Castro's reaoent (BOP, PyBop), 0-benzotriazolyl-N,N,N',N'-tetramethyluronium salts (HBTU), 0-azabenzotriazolyl-N,N,N',N'-tetramethyliironiiim salts (TATU), diethylphosphoryl cyanide (DEPCN), 2,5-diphenyl-2,3-dihydro-3-oxo-4-hydroxythiophene dioxide (Steqlich's reagent; HOTDO), and 1,1'-carbonyldiimidazole (CDI). The coupling reagents can be employed alone or in combination with additives such as N,N-dimethyl- 4~aminopyridine (DMAPJ, N-hydroxy-benzotriazole (HOBt), N-hydroxybenzotriazine (HOOBt), N-hydroxysuccinimide (HOSu) or 2-hydroxypyridine. Although the use of protecting groups is generally not necessary in enzymatic peptide synthesis, reversible protection of reactive groups not involved in formation of the amide linkage is necessary for both reactants in chemical synthesis. Three conventional protective group techniques typically used for chemical peptide synthesis are: the benzyloxycarbonyl (Z), the t-butoxycarbonyl (Boc) and the 9-fluorenylmethoxycarbonyl (Fmoc) techniques. Identified in each case is the protective group on the a-amino group of the chain-extending unit. A detailed review of amino-acid protective groups is given by Muller, Methpden der oraanischen Chemie Vol. XV/l, pp 20-90G, Thieme Verlag, Stuttgart (1974). . The units employed for assembling the peptide chain can be reacted in solution, in suspension or by a method sirr.ilar to that described by Merrifield in J. Amer. Chem. Soc. 85 (1953) 2149. In one method, peptides are assembled sequentially or by fragment coupling using the 2, Boc or Fmoc protective group technique, with one of the reactants in the Merrifield technique being bonded to an insoluble polymeric support (also called resin hereinafter). This typically entails assembling the peptide sequentially on the polymeric support using the Boc or Fmoc protective group technique, with the growing peptide chain covalently bonded at the C terminus to the insoluble resin partic]es. This procedure allows the removal of reagents and by¬products by filtration, eliminating the need to recrystallize intermediates. The protected amino acids can be linked to any suitable polymer, which must be insoluble in the solvents used and have a stable physical form which permits filtration. The polymer must contain a functional group to which the first protected amino acid can be covalently attached. A wide variety of polymers are suitable for this purpose, for example, cellulose, polyvinyl alcohol, polymethacrylate, sulfonated polystyrene, chloromethylated styrene/divinylbenzene copolymer (Merrifield resin), 4-methylbenzhydrylamine resin (MBHA-resin), phenylacetamidomethyl resin (Pam-resin), p-benzyloxy-benzyl-alcohol-resin, benzhydryl-amine-resin '^HA-resin), 4-(hydroxymethyl)-benzoyl-oxymethyl-resin, the resin of Breipohl ed al. (Tetrahedron Letters 28 (1987) 565; supplied by BACHEM), 4-(2,4-dimethoxyphenylaminomethyl) phenoxy resin [supplied by Novabiocherr.) or o-chlorotrityl-resin (supplied by Biohellas). Solvents suitable for peptide synthesis include any solvent which is inert under the reaction conditions, for example, water, H,N-dimethylformamide (DKF), dimethyl sulfoxide (DMSO), acetonitrile, dichloromethane (DCM), 1,4-dioxane, tetrahydrofuran (THF), N-methyl-2-pyrrolidone {!"■:?) and mixtures of these solvents. Peptide synthesis on the polymeric support can be carried out in a suitable inert organic solvent in which the amino acid derivatives and starting materials employed are soluble. Particularly useful solvents are, for example, DMF, DCM, NMP, acetonitrile, DMSO and mixtures thereof, due to their resin swelling properties. Following synthesis, the peptide is removed [commonly referred to as cleaved) from the polymeric support. The conditions under which this cleavage is accomplished are well known in the art of peptide synthesis and depend in part on the type of resin employed. The cleavage reactions most commonly used are acid- or palladium-catalyzed, the acid catalyzed cleavage being conducted in, for example, liquid anhydrous hydrogen fluoride, anhydrous trifluoromethanesulfonic acid, dilute or concentrated trifluoroacetic acid, and acetic acid/dichloromethane/ trifluoroethanol mixtures. The palladium-catalyzed cleavage can be carried out in THF or THF-DCM-mixtures in the presence of a weak base such as morpholine. Certain protecting groups are also cleaved off under these condi tionp. Partial deprotection of the peptide may also be necessary prior to certain derivatization reactions. For example, peptides dialkylated at the N-terminus can be prepared either by coupling the appropriate N,N-di-alkylamino acid to the peptide in solution or on the polymeric support or by reductive alkylation of the resin-bound peptide in DMF/1% acetic acid with NaCNBH3 and the appropriate aldehyde or by hydrogenation of the peptide in solution in the presence of aldehyde or ketone and Pd/C. The various non-naturally occurring amino acids as well as the various non-amino acid moieties disclosed herein may be obtained from commercial sources or synthesized from commercially-available materials usina methods known in the art. For example, amino acid building blocks with R1 and R2 moieties can be prepared according to E. Wuensch, Huben Keyl, Hethoden der oroanischen Phpmii> Vol. XV/i, p. 3 06, Thieme Verlag, Stuttgart (1974) and literature cited therein. Peptides with gamma-or delta-lactam bridges can be prepared by incorporating the appropriate lactam-bridged dipeptide units (R. Freidinger, J. Org. Chem. (1982) 104-109) into the peptide chain. Peptides with thiazole-, oxazol-, thiazolin- or oxazolin-containing dipeptide building blocks can be prepared by Incorporating the appropriate dipeptidic units (P. Jouin et il.. Tetrahedron Letters (1992), pp. 20B7-2810; P. Wipf et 32., Tetrahedon Letters {1992), pp. 907-910; W.R. Tully, J. tfed. Chem. (1991), p 206S; Synthesis (1987), p 235) into ;he peptide chain. The following procedures are intended to illustrate nethods useful for preparation of compounds of Forumla I. tfhen applicable, amino acids are abbreviated using the toiown three letter codes. Other meanings used are: ^e2Val=N,N~dimethylvaline. MeVal=N-methylvaline, TFA -Lrifluoroacetic acid, Ac = acetic acid, Bu GENERAL SYNTHETIC PROCEDURES I. Compounds of Formula I of the present invention are either synthesized by classical solution synthesis using standard Z- and Boc-methocclagy as described above or by standard methods of solid-phase synthesis on a completely automatic model 431A synthesizer supplied by APPLIED BIOSYSTEMS. The apparatus uses different synthetic cycles for the Boc and Fmoc protective group techniques. In the case of solid phase synthesis, the N,N-dialkyl-penta- or hexapeptide acids are liberated from the solid support and further coupled with the corresponding C-terminal amines in solution. BOP-Cl and PyBrop were used as reagents for coupling of the amino acid following the N-methylamino acids. The reaction times were correspondingly increased. For reductive alkylation of the N-terminus, the peptide-resin was deprotected at the N terminus and then reacted with a 3 - fold molar excess of aldehyde or ketone in DMF/1% acetic acid with addition of 3 equivalents of NaCNBH3. After the reaction was complete (negative Kaiser test) the resin was washed several times with water, isopropanol, DMF and dichloromethane. In solution synthesis, the use of either Boc~protected amino acid NCAs (N-tert-butyloxycarbonyl-amino acid-N-carboxy-anhydrides), Z-protected amino acid NCAs (N-benzyloxycarbonyl-amino acid-N-carboxy-anhydrides), or the use of pivaloylchloride as condensing agent respectively is most advantageous for coupling of the amino acid following the N-methylamino acids. Reductive alkylation of the N terminus can, for example, be achieved by reaction of the N-terminally deprotected peptides or amino acids with the corresponding aldehydes or ketones using NaCNBH3 or hydrogen, Pd/C. Synthetic cycle for the Boc protective group technique; 30°* trifluoroacetic acid in DCM 1x3 min 50V trifluoroacetic acid in DCM 1 x 1 min DCM washing 5% d5isopropylethylamine in DCM 5x1 min 5% diisopropylethylamine in NKP 1 x 1 min KMP washing 5x1 min Addition of preactivated protected amino acid (DCC and 1 equivalent of HOBt in NMP/DCH); Peptide coupling (1st part) 1 x 30 min Addition of DMSO to the reaction mixture until it contains 20% DMSO by volume; Peptide coupling {2nd part) 1 x 16 min 9. Addition of 3.8 equivalents of diisopropylethylamine to the reaction mixture; Peptide coupling (3rd part) 1x7 min 10. DCM washing 3x1 min 11. If conversion is incomplete, repetition of coupling (back to 6) 12 . 10% acetic anydride, 5% diisopropylethylamine in DCM 1x2 min 13. 10% acetic anhydride in DCM 1x4 min 14. DCM washing 4x1 min 15. Back to 1. BOP-Cl and PyBrop were used as reagents for coupling cf the amino acid following N-methylamino acids. The reaction times were correspondingly increased. In solution synthesis, the use of either Boc-protected amino acid NCAs (N-tert-butyloxycarbonyl-amino acid-N-carboxy-anhydrides) or Z-protected amino acids NCAs respectively is most advantageous for this type of coupling. lxl min 1x4 min 1 x 16 min 5x1 min 1 x 61 min 3x1 min 1 2 3 4 , 5. 6 7 Synthetic cycle for the Fmoc protective group technique: DMF washing 20% piperidine in DMF 20% piperidine in DMF DMF washing Addition of the preactivated protected amino acid (activation by 1 equivalent of TBTU and 5 equivalents of DIPEA in DMF) ; Peptide coupling DMF washing If conversion is incomplete, repetition of coupling (back to 5) 8. 10% acetic anhydride in DMF 1 x B min 9. DMF washing 3x1 min 10. Back to 2. BOP-cl and PyBrop were used as reagents for coupling on the amino acid following the N-methylamino acids. The reaction times were correspondingly increased. 11. Reductive Alkylation of the H-terminus The peptide-resin prepared in la or lb above was deprotected at the N-terminus (steps 2-4 in lb or 1-6 in la) and then reacted with a 3-fold molar excess of aldehyde or ketone in DMF/1% acetic acid with addition of 3 equivalents of NaCNBHj. After reaction was complete (negative Kaiser test) the resin was washed several times with water, isopropanol, DMF and dichloromethane. III. Workup of the peptide-resins obtained as in la and II The peptide-resin w&s dried under reduced pressure and transferred into a reaction vessel of a TEFLON HF apparatus -(supplied by PENINSULA). Addition of a scavenger, for example,, anisole (Iml/g of resin) , and in the case of tryptophan-containing peptides of a thiol to remove the indolic formyl group, for example, ethanedithiol (0.5 ml/g of resin), was followed by condensing in hydrogen fluoride (10 ml/g of resin) while cooling with liquid N2. The mixture was allowed to warm to 0°C and stirred at this temperature for 45 minutes. The hydrogen fluoride was then stripped off under reduced pressure, and the residue was washed with ethyl acetate in order to remove remaining scavenger. The peptide was extracted with 30% acetic acid and filtered, and the filtrate was lyophilized. Work-up of the peptide-resins obtained as in lb and II The peptide-resin was dried under reduced pressure and then subjected to one of the following cleavage procedures, depending on the amino acid composition (Wade, Tregear, Howard Florey Fmoc Workshop Manual, Melbourne 19B5). Cleavage conditions: TFA Scavenger Reaction time 1. 95V 5% water l.S h 2. 95* 5% ethanethiol/ anisole (1:3) 1.5 h The suspension of the peptide-resin in the suitable TFA mixture was stirred at room temperature for the stated time and then the resin was filtered off and washed with TFA and DCM. The filtrate and the washings were concentrated, and the peptide was precipitated by addition of the diethyl ether. After cooling in an ice bath, the precipitate was filtered off, taken up in 30% acetic acid and lyophilized. When an o-chlorotrityl-resin (supplied by Biohellas) is used, the suspension of the peptide-resin in an acetic acid/ trifluoroethanol/ dichlorcmethane mixture (1.-1:3) is stirred at room temperature for 1 h. The resin is then filtered off with suction and thoroughly washed with the cleavage solution. The combined filtrates are concentrated in vacuo and treated with water. The precipitated solid is removed by filtration or centrifugation,. washed with diethyl ether and dried under reduced pressure. VI. Purification and characterization of the peptides Purification was carried out by gel chromatography (SEPHADEX G-10, G-15/l0% HOAc, SEPHADEX LH20/MeOH) medium pressure chromatography {stationary phase: HD-SIL C-18, 20-45 micron, 100 Angstrom; mobile phase: gradient with A=0.1% TFA/MeOH, B«0.1V TFA/water) or preparative HPLC (stationary phase: water Delta-Pak C-18, 15 micron, 100 Angstrom; mobile phase: gradient with A= 0.1% TFA/MeOH, B= 0.1% TFA/water). The purity of the resulting products was determined by analytical HPLC (stationary phase: 100 2.1 mm VYDAC C-18, 51, 300 Angstrom; mobile phase: acetonitrile-water gradient, buffered with 0.1% TFA, 40°C>. Characterization was by amino acid analysis and fast atom bombardment mass spectroscopy. SPECIFIC SYNTHETIC PROCEDURES EXAMPLE 1A: N,N-dimethyl-Val-Val-K-methyl-Val-Pro-Pro-Val-Phe-NHS 1.98 g of Fmoc-RlNK-resin (substitution 0.46 mmol/g), corresponding to a batch size of 0.64 mmol, were reacted as in lb above with 1.26 mmol each of Fmoc-Phe-OH Fmoc-Val-OH Fmoc-Pro-OH Fmoc-Pro-OH Fmoc-N-methyl-Val-OH Fmoc-Val-OH Fmoc-Val-OH The amino acid following the N-methyl amino acid was coupled on with PyBrop as coupling reagent. After the iterative synthetic cycles were completed, the peptide-resin underwent N-terrriinal deprotection (steps 2-4 in lb) and was further reacted with aqueous formaldehyde solution as in II and then dried under reduced pressure. The resulting resin was subjected to TFA cleavage as in IV. The crude product (590 mg) was purified by gel filtration (SEPHADEX-LH-20). The yield was 295 mg. EXAMPLE 1A: Example 1 can also be prepared via classical solution phase methodology. The synthesis of N,N-dimethyl-Val-Val-N-methyl-Val-Pro-Pro-Val-Phe-NH2 and its associated intermediates is described in the following paragraph. Z-MeVal-Pro-OMe 66.25 g (250 mmol) of Z-MeVal-OH were dissolved in 250 ml of dry dichloromethsne. After addition of 36.41 ml (262.5 mmol) of triethylamine, the reaction mixture was cooled to -25°C and 32.37 ml (262.5 mmol) pivaloyl chloride were added. After stirring for 2.5 hours, 41.89g (250 mmol) of H-Pro-OMe-HCl in 250 ml of dichloromethane, neutralized with 36.41 ml (262.5 mmol) triethylamine at 0°C, were added to the reaction mixture. Stirring was continued for 2h at -25°C and overnight at room temperature. The reaction mixture was diluted with dichloromethane and thoroughly washed with saturated aqueous KaHC03 solution (3X), water (IX), 5% citric acid (3X) and saturated NaCl solution. The organic phase was dried over sodium sulfate, filtered and evaporated to dryness. The residue (91.2-1 g) was stirred with petroleum ether overnight and filtered. 62.3 g of product were obtained. b) H-HeVal-Pro-OHe 4B.9 g (130 mmol) Z-MeVal-Pro-OMe were dissolved in 490 ml of methanol. After addition of 10.9 ml {130 mmol) concentrated hydrochloric acid and 2.43 g of 10% palladium/charcoal, the reaction mixture was hydrogenated. Filtration and evaporation to dryness yielded 3 6.43 g of product. c) Z-Val-MeVal-Pro-OMe 1B.1 g (65 mmol) of H-MeVal-Pro-OMe, 21.6 g (79 mmol) Z-Val-N-carboxyanhydride and 22.8 ml (130 mmol) diisopropylethylamine were stirred in 110 ml of DMF at 40°C for 2 days. After evaporation of DMF, dichloromethane was added and the organic phase washed with saturated aqueous NaHC03 solution (3X), water (IX) S% citric acid (3X) and saturated NaCl solution. The organic phase was dried over sodium sulfate, filtered and evaporated to dryness. The product {29.3 g) was obtained as a viscous oil. d) H-Val-MeVal-Pro-OMe 29.3 g (SI.6 mmol) of Z-Val~MeVal-Pro-bMe were dissolved in 230 ml of methanol. After addition of 1.15 g of 10% palladium/charcoal, the reaction mixture was hydrogenated. Filtration and evaporation to dryness yielded 21.96 g of product. e) Z -Val-Val-MsVal-Pro-OMe 15.29 g (61 mmol) of Z-Val-OH and 21.9(7 g (Si mmol) of H-Vrl-MeVal-Pro-OMe were dissolved in 610 ml of dichloromethane and cooled to 0°C. After addition of 8.16 mol(73.2 mmol) of N-methylmorpholine,' 2.77 g (20.3 mmol) of HOBt and 11.74g (61 mmol) of EDCI, the reaction mixture was stirred overnight at room temperature, diluted with dichioromethane and thoroughly washed with saturated aqueous NaHC03 solution (3X), water (IX), 5% citric acid Z-Val-Val-MeVal-Pro-OH 31.96 g (57 mmol) of Z-Val-Val-MeVal-Pro-OMe were dissolved in 250 ml of methanol. 102.6 ml of a IN LiOH solution was added and the mixture stirred overnight at room temperature. After addition of 500 n-J of water, the aqueous phase was washed three times with ethyl acetate. The organic phase was dried over sodium sulfate, filtered and evaporated to dryness yielding 30.62 g of the desired product as a white solid. Z-Val-Val-MeVal-Pro-Pro-Val-Phe-NH2 25 g (43.3 mmol) of Z-Val-Val-MeVal-Pro-OH and 15.59 g (43.3 mmol) of K-Pro-Val-Phe-NH3 were suspended in 430 tnl of dry dichioromethane. After cooling to 0°C, 5.61 ml (52 mmol) N-methylmorpholine, 1.97 g (15 mmol) of H03t and B.33 g (43.3 mmol) of EDCI were added and the reaction mixture stirred overnight at room temperature. The solvents were evaporated, the residue dissolved in 640 ml of dichioromethane and thoroughly washed with saturated aqueous NaHCO, solution (4X), water (IX), 5% citric acid (3X) and saturated NaCl solution. The organic phase was dried over sodium sulfate, filtered and evaporated to dryness to yield 33.04 g of the product. The crude product was chromatographed on a silica gel column with 20% MeOH/hexane. 18.32 g of the desired product were obtained. h) N,N-dimethyl-Val-Val-HeVal-Pro-Pro-Val-Phe-NH2 18.32 g of Z-val-Val-MeVal-Pro-Pro-Val-Phe-NH2 were dissolved in 80 ml of methanol. 0.4 g of 10* palladium/carbon were added under nitrogen atmosphere and the reaction mixture hydrogenated at room temperature for 4 hours. After addition of 6.22 ml (81.24 mmol) of a 37% aqueous formaldehyde solution, hydrogenation was continued for 5 hours. Filtration and evaporation of the solvent gave rise to 15.S g of crude product. Further purification was achieved by dissolving the peptide in water, adjusting the pH to 2 and extracting the aqueous phase three times with ethyl acetate. The aqueous phase was then adjusted to pK 8-9 and extracted four times with ethyl acetate. The organic phase was washed with water and dried over sodium sulfate, filtered and.evaporated to yield 11.3 g of purified product as a white powder. The comoound was characterized by fast atom bombardment mass spectrometry ( [M+H] * = 797). EXAMPLE 2A: N,N-dimethyI-Val-Val-NMe-Val-pro-[l- [thiazol-(2)-yl]-2-phenyl}-ethylamide 4.11 g of Fmoc-Pro-p-alkoxybenzyl-alcohol-resin (substitution 0.73 mmol/g), corresponding to a batch size of 3 mmol, were reacted as in lb with 4.5 mmol each of Fmoc-N-MeVal-OH Fmoc-Val-OH Fmoc-Val-OH The amino acid following the N-methylamino acid was in this case reacted with double coupling using PyBrop or Bop-Cl with increased reaction times. After the synthesis was complete, the peptide-resin underwent N-terminal deprotection (Steps 2-4 in lb), and was further reacted with aqueous formaldehyde solution as in II and then dried under reduced pressure. The resin obtained in this way was subjected to TFA cleavage as in IV. The crude product (750 mg) was employed directly for the next coupling. 100 mg of this compound were reacted with 45 mg of (S) -2-[l-amino-2-phenylethyl]thiazole and 230 mg of PyBop with the addition of 192 microliters of DIPEA in DMF at room temperature for 2 days. The reaction mixture was purified by gel chromatography (SSPHADEX LH-20, methanol} and the product fractions were combined. 83 mg of product were obtained. EXAMPLE IB Ke2Val-Val-MeVal-Pro-Pro-NHCH(CH3)2 a) Z-MeVal-:Pro-OKe 66.25 g (250 tnmol) Z-MeVal-OH were dissolved in 250 ml dry dichloromethane. After addition of 36.41 ml (262.5 mmol) triethylamine, the reaction mixture was cooled to -25°C and 32.27 ml (262.5 mmol) pivaloyl chloride were added. After stirring for 2.5 h, 41.69 g (250 mmol) H-Pro-OMe x HC1 in 250 ml dichloromethane, neutralized with 36.41 ml (262.5 mmol) triethylamine at 0°C, were added to the reaction mixture. Stirring continued for 2 h at -25°c and overnight at room temperature. The reaction mixture was diluted with dichloromethane and thoroughly washed with saturated aqueous KaHC03 solution (3x), water (Ix), S£ citric acid (3x) and saturated NaCl solution. The organic phase was dried over sodium sulfate filtered and evaporated to dryness. The residue (91.24 g) was stirred with petroleum ether overnight and filtered. 62.3 g of product were obtained. H-MeVal-Pro-OMe 48.9 g (130 mmol) Z-MeVal-Pro-OMe were dissolved in 490 ml methanol. After addition of 10.9 ml (130 mmol) concentrated hydrochloric acid and 2.43 g 10 % Palladium/charcoal, the reaction mixture was hydrogenated. Filtration and evaporation to dryness yielded 35.43 g of the product. Z-Val-MeVal-Pro-OMe 18.1 g (65 mmol) H-MeVal-Pro-OMe, 21.6 g (76 mmol) Z-Val-N-carbo>:yanhydride and 22.8 ml (130 mmol) diisopropylethylamine were stirred in 110 ml DMF at 40°C for 2 d. After evaporation of DMF, dichloromethane was added and the organic phase washed with saturated aqueous NaHC03 solution (3x), water (lx), SV citric acid (3x) and saturated NaCl solution. The organic phase was cried over sodium sulfate and evaporated to dryness. The product (29.3 g) was obtained as a viscous oil. K-Val-MeVal-Pro-OMe 29.3 g (61.6 mmol) of Z-Val-MeVal-Pro-OMe were dissolved in 230 ml methanol. After addition of 1.15 g 10% Palladium/charcoal, the reaction mixture was hydrogenated. Filtration and evaporation to dryness yielded 21.96 g of the product. Z-Val-Val-MeVal-Pro-OMe 15.29 g (61 mmol) Z-Val-OH and 21.96 g (61 "mmol) K-Val-MeVal-Pra-OMe were dissolved in 610 ml dichloromethane and cooled to 0°C. After addition of B.ie ml {73.2 mmol) N-Methylmoropholine, 2.77 g (20.3 mmol) HOBt and 11.74 g (61 mmol) EDCI, tb" reaction mixture was stirred overnight at room temperature, diluted with dichloromethane and thoroughly washed with saturated aqueous NaHC03 solution (3x), water (lx), 5% citric acid (3x) and saturated NaCl solution. The organic phase was dried over sodium sulfate, filtered and evaporated to dryness to yield 31.96 g of the product. Z-Val-Val-MeVal-Pro-OH 31.96 g (57 mmol) Z-Val-Val-MeVal-Pro-OMe were dissolved in 250 ml methanol. 102.6 ml of a 1 N LiOH solution was added and the mixture stirred overnight at room temperature. After addition of 500 ml water, the aqueous phase was washed three times with ethyl acetate, adjusted to pH 2 at 0°C and extracted three times with ethyl acetate. The craanic phase was dried over sodium sulfate, filtered and evaporated to dryness yielding 30.62 g of the desired product as a white solid. Z-Val-Val-MeVal-Pro-Pro-NHCH(CH.,)2 2 g (3.35 mmol) Z-Val-Val-KeVal-Pro-OH and 0.664 g (3.35 mmol) H-Pro-NHCH(CH3); were dissolved in 34 ml of dry dichloromethane. After cooling to 0°C, 1.35 ml (12.1 mmol} K-methylmorpholine, 0.H4 g (0.84 mmol) HOBt and 0.64 5 g (3.3 5 mmol) EDCI were added and the reaction mixture stirred overnight at room temperature. 80 ml dichloromethane were added and the organic phase thoroughly washed with saturated aqueous NaHC03 solution (3x), water (lx), 5V citric acid (3x) and saturated NaCl solution (lx) . The organic phase was dried over sodium sulfate, filtered and evaporated to dryness to yield 1.96 g of the product which was used in the next reaction without further purification. i) Me2Val-Val-MeVal-Pro-Pro-NHCH(CH3)2 1.9G g Z-Val-Val-MeVal-Pro-Pro-NHCH(CH3>2 were dissolved in 11 ml methanol. 0.054 g 10V Pd/C were added under nitrogen atmosphere and the reaction mixture hydrogenated at room temperature for 4 h. After addition of 0.86 ml (11.24 mraol) of a 37V aqueous formaldehyde solution and 0.281 g 10* Pd/C, hydrogonation was continued for 5 h. Filtration and evaporation of the solvent gave rise to 2.77 g of crude product. Further purification was achieved by dissolving the peptide in water, adjusting the pH tc 2 and extracting the aqueous phase three times with ethyl acetate. The aqueous phase was then adjusted to pH 8-9 and extracted four times with dichloromethane . The organic phase was dried over sodium sulfate, filtered and evaporated to yield 1.37 g of purified product as a white foam. The compound was further-purified using medium pressure liquid chromatography (10-50% A in 10 min.; 50-90% A in 320 min.J. Fractions containing the product were combined, lyophilized, redissolved in water and the pH adjusted to g with 1 N LiOH. After extraction with dichloromethane, the organic phase was dried over sodium sulfate, filtered and evaporated to dryness. Lyophilization led to 500 tng of pure product, which was characterized by fast atom bombardment mass spectrometry ([K+K]* = 593). EXAMPLE 2B Me2Val-Val-MeVal-Pro-Pro-NHC£CH3)3 a) Z-Val-Val-MeVal-Pro-Pro-NHC(CH3)3 2 g (3.35 mmol) Z-Val-Val-MeVal-Pro-OH and 0.692 g (3.35 mmol) H-Pro-NHC(CH3)3 were dissolved in 34 ml of dry dichloromethane. After cooling to 0°C, 1.35 ml (12.1 mmol) N-methylmorpholine, 0.114 g (0.84 mmol) HODt and 0.64S g (3.35 mmol) EDCI were added and the reaction mixture stirred overnight at room temperature. 60 ml dichloromethane were added and the organic phase thoroughly washed with saturated aqueous NaHC03 solution (3x), water (lx), 5% citric acid (3x) and saturated KaCl solution (lx). The organic phase was dried over sodium sulfate, filtered and evaporated to dryness to yield l.B g of the product which was used in the next reaction without further purification. b) Ke2Vsl-Val-KeVal-Pro-Pro-NHC(CH3)3 l.B g Z~Val-Val-MeVal-Pro-Pro-NHC(CH3)3 were dissolved in 10 ml methanol. 0.045 g 10% Pd/C were added under nitrogen atmosphere and the reaction mixture hydrogenated at room temperature for 4 h. After addition of O.aS ml (11.24 mmol) of a 37% aqueous formaldehyde solution and 0.252 g 10% Pd/C, hydrogenation was continued for 5 h. Filtration and evaporation of the solvent gave rise to 1.82 a of crude product. The compound was further purified using medium pressure liquid chromatography (10-50% A in 10 min.; i0-90% A in 320 min.). Fractions containing the product were combined, lyophilized, redissolved in water and the pH adjusted to 9 with 1 H LiOH. After extraction with dichloromethane, the organic phase was dried over sodium suirate EVALUATION OF BIOLOGICAL ACTIVITY In vivo Methodology The combination of a compound of Formula I and paclitaxel, taxotere or a modified taxane or taxoid analog was further tested in various preclinical assays for in vivo activity, which are indicative of clinical utility. The P388 (ascites model), LX-1, CX-1 and PC-3 (human tumor xenograft models for lung, colon and prostate) tumor models are all suitable for use in this invention. In general, any dosing regimen which appears to provide an acceptable level of antitumor activity for both agents is suitable. Any acceptable method of drug administration can be used in the combination therapy of this invention and can be determined using techniques well known to those of skill in the art. In addition, the drugs can be administered either simultaneously or sequentially, in any order. ^3 8 8 MODEL The P3SS tumor model employs a murine lymphocytic leukemia cell line (See Schabel et al., Pharmac. Ther. A, 1:411-435). The P3B8 tumor cells used in this invention, were harvested from donor mice by peritoneal lavage at day 7 poFt transplant. lxlO6 F388 tumor cells were then implanted intraperitoneally in a volume of 0.5 ml in mice. A typical dosing regimen includes initiation of i treatment approximately one day post transplant followed by treatment on days 5 and 9 post transplant. Generally the compounds of Formula I are administered intravenously (i.v.) and the paclitaxel, taxotere or modified taxane or taxoid analog is administered intraperitoneally (i.p.). Therapeutic results of the combinations df the invention against P388 cells, are presented in terms of increase in lifespan reflected by the relative median survival time (MST) of treated (T) versus control (C) group {survival period for untreated mice is generally in the range of 11 to 13 days) and is represented as %T/C values. According to the National Cancer Institute guidelines a VT/C in the range or 128-190* indicates a drug with moderate to good activity. In addition, the Net log Cell Kill is used to compare efficacy of different schedules and combinations, and is calculated as follows: Net log Cell Kill = ffT-C) - duration of_treatment I x 0.332 Doubling Time Jvhere, Doubling Time = time required for control tumors to double once (0.4 days). T and C = the median survival time (days) for the control (C) and treated (T) mice. Duration of: treatment with drug 0.332 = Derived constant A positive Net log Cell Kill number indicates that fever tumor eel1, r. are present at the end of treatment. A negative number indicates that the tumor was still growing during treatment. EXAKPLE 3: Combination Treatment Using Compound (xvii) and Paclitaxel in the P3S8 Tumor Model 1 x 106 P38S tumor cells were transplanted intraperitonmlly in a volume of 0.5 ml in mice. Treatment was initiated approximately 1 day later followed by treatment on both day 5 and day 9, post transplant. Compound (xvii) was administered IV while paclitaxel was administered IP. Compound (xvii) was administered at either 20, 40 or 60 mg/kg and paclitaxel at either 10, 20 ;>r 30 mg/kg. The dosing was sequential with compouond ixvii) being administered first followed by paclitaxel one nour later. RESULTS: The results from Example 3 are shown in Table 1. The data in Table 1 shows that single drug treatment resulted in an optimal %T/C of 175% for compound (xvii) corresponding to a Net log Cell Killing (NICK) of 0.66 when administered intravenously at a dose of 60 mg/kg and an optimal %T/C of 1B3% corresponding to a NICK of 1.33 for paclitaxel when administered intraperitoneally at a dose of 10 mg/kg. For combination drug treatment the data of Table 1 show that the combination of 60 mg/kg (xvii) and 20 mg/kg of paclitaxel resulted in a significant ircrease in life span (P Value less than 0.001, as determined by the Mann-Whitney Test) and an optimal VT/C value of 242% corresponding to a NICK of 5.98 with 38% of the animals surviving more than 60 days. HUMAN TUMOR XENOGRAFTS MODEL Human tumors from lung {LX-D, colon (CX-1) and prostate (PC-3) which had been grown in athymic nude mice were transplanted (xenografted) into new recipient mice, as is well known in the art. The transplanted tumor fragments were approximately 50 mg in size. The day of transplantation was designated as day 0. The combination therapy of the present invention was evaluated for anti¬tumor efficacy following administration to the xenograft-bearing mice. Combination therapy was accomplished by intravenous administration of both drugs. The Q2dx3; 5, 12 and.19 injection schedule was followed with paclitaxel being administered one hour after Compound (xvii). in other words, treatment consisted of 3 cycles, starting on days 5, 12 and 19 post tumor implantation. One cycle of treatment consisted of treatment every other day for a total of three times. The optimal dose for single dose administration of both Compound (xvii) and paclitaxel used in the LX-1 and CX-i types of human xenograft models tested, can be found in Tables 2-3, with no optimal dose determined with the PC-3 model. Tumor diameters and body weights were measured twice weekly. Tumor volumes were calculated using the diameters measured with Vernier calipers, and the formula: (length x width2} / 2 ■= mg of tumor weight Mean tumor weights (KTW) were calculated for each treatment group, and T/C values determined for each group relative to the untreated control tumors. Results are also presented as Net log Cell Kill and are calculated as follows: Net log Cell Kill = \ (T-C) - duration of treatment! x 0.332 Doubling Time T and C = The median days required for the control and treated tumors to reach a specified tumor size, in this instance 2000 mm3 . Doubling Time = Time required for control tumors to double in size. 0.332 = Derived constant EXAMPLE 4: Combination Treatment Using Compound 103793 and Paclitaxel in the LX-1 Human Tumor Xenograft Model The Q2dx3; 5, 12 and 19 dosing regimen described above was used in this example. Paclitaxel was administered IV one hour after Compound (xvii) was administered IV. The optimal single dose of both paclitaxel and Compound (xvii) can be determined from Table 2. EXAMPLE 5.- Combination Treatment Using Compound 103793 and Paclitaxel in the CX-1 Human Tumor Xenograft Model The Q2dx3; 5, 12 and 19 dosing regimen described above was used in this example. Paclitaxel was administered IV one hour after Compound (xvii) was administered IV. The optimal single dose of both paclitaxel and Compound (xvii) can be determined from Table 3. EXAMPLE 6: Combination Treatment Using Compound 103793 and Paclitaxel in the PC-3 Human Tumor Xenograft Model The Q2dx3; 5, 12 and 19 dosing regimen described above was used in this example. Paclitaxel was administered IP one hour after Compound (xvii) was administered IV. The optimal single dose of both paclitaxel and Compound (xvii) was not determined. RESULTS: The results obtained using the Human Xenograft Model to assess anti-tumor efficacy of the combination therapy of the present invention are presented in Tables 2-4. The data presented represents results from preliminary experiments. The data in Table 2 show that the optimal combination of compound (xvii) and paclitaxel was 15 mg/kg and 10 mg/kg respectively, in the LX-1 model. The combination resulted in some regressions and tumor growth delay. However, the same combination schedule in the CX-1 model did not result in any advantage over the single drug treatment as shown in Table 3. In the PC-3 model, there was no beneficial effect of the combination as compared to single drug treatment. However, the optimal dose for single dose administration was not determined. 1 The following compounds were prepared and can be prepared according to the Examples: 3. Xaa Val Xab Pro Xac 4. Xaa Val Xab Pro Xad 5. Xaa Val Xab Pro Xae 6. Xaa Val Xab Pro Xaf 7. Xaa Val Xab Pro Xag 8. Xaa Val Xab Pro Xah 9. Xaa Val Xab Pro Xai 10. Xaa Val Xab Pro Xak 11. Xaa Val Xab Pro Xal 12. Xaa Val Xab Pro Xam 13. Xaa Val Xab Pro Xan 14. Xaa Val Xab Pro Xao 15. Xaa Val Xab Pro Xap 16. Xaa Val Xab Pro Xaq 17. Xaa Val Xab Pro Xar 1H. Xaa Val Xab Pro Xas 19. Xaa Val Xab Pro Xat 20. Xaa Val Xab Pro Xau 21. Xaa Val Xab Pro Xav 22. Xaa Val Xab Pro Xaw 23. Xaa Val Xab Pro Xax 2«. Xaa Val Xab Pro Xay 25. Xaa Val Xab Pro Xaz 26. Xaa Val Xab Pro Xba 27. Xaa Val Xab Pro Xbb 28. Xaa Val Xbc Pro Xay 29- Xaa. Val Xab Pro Xbd 30. Xaa Val Xab Pro Xbe 31. Xaa Val Xab Pro Xbf 32. Xaa Val Xab Pro Xbg 33. Xaa Val Xab Pro Xbh 34. Xaa Val Xab Pro Xbi 35. Xaa Val Xab Pro Xbk 36. Xaa Val Xab Pro Xbl 37. Xaa Val Xab Pro Xbm 38. Xaa Val Xab Pro Xbn 39. Xaa Val Xab Pro Xbo 40. Xaa Val Xab Pro Xbp 41. Xaa Val Xab Pro Xbq 42. Xaa Val Xab Pro Xbr 43. Xaa Val Xab Pro Xbs 44. Xaa Val Xab Pro Xbt 45. Xaa Val Xab Pro Xbu 46. Xaa Val Xab Pro Xbv 47. Xaa Val Xab Pro Xbw 48. Xaa Val Xab Pro Xbx 4S. Xaa Val Xab Pro Xby 50. Xaa Val Xab Pro Xbz 51. Xaa Val Xab Pro Xca 52. Xaa Va] Xab Pro Xcb 53. Xaa Val Xab Pro Xcc 54. Xaa Val Xab Pro Xcd 55. Xaa Val Xab Pro Xce 56. Xaa Val Xab Pro Xcf 57. Xaa Xdf Xab Pro Xay 58. Xaa Val Xab Pro Xch 5?. Xaa Val Xab Pro Xci 60. Xaa Val Xab Pro Xck 61. Xaa Val Xab Pro Xcl 62. Xaa Val Xab Pro Xcm 63. Xaa Val Xab Pro Xcn 64. Xaa Val Xab Pro Xco 65. Xaa Val Xab Pro Xcp 66. Xaa Val Xab Pro Xcq 67. Xaa Val Xab Pro Xcr 68. Xaa Val Xab Pro Xcs 69. Xaa Val Xab Pro Xct - 70. Xaa Val Xab Pro Xcu 71. Xcw Val Xab Pro Xcv 12. Y.cx Val Xab Pro Xcv 73. Xaa Val Xab Pro Pro Xcy 74. Xaa Val Xab Pro Pro Xcz 75. Xaa Val Xda Pro Xcv 16. Xaa Xdb Xab Pro Xcv 77. Xdc Val Xab Pro Xcv 78. Xaa lie Xab Pro Xcv 79. Xdd Val Xab Pro Xcv 80. Xde Val Xab Pro Xcv 81. Xaa Xdf Xab Pro Xcv 82. Xaa Val Xab Pro Xcg 63. Xaa Val Xab Pro Pro Xdg S4 . Xaa Val Xab Pro Pro Xdh 85. Xaa Val Xab Pro Pro Xdi 86. 'Aaa Val Xab Pro Pro Xdk 87. Xaa Val Xdl Pro Xcv 68. Xde Val Xab Pro Xay 69. Xaa Val Xdl Pro Xay 90. Xaa Val Xab Pro Xdm 91. Xaa Val Xab Pro Xdn 52. Xaa Val Xab Pro Xdo 53. Xaa Val Xah Pro Xdp 94. Xaa Val Xab Pro Xdq 95. Xaa Val Xab Pro Pro Xdr 96. Xaa Val Xab Pro Xds 97. Xaa Val Xbc Pro Xcv 98. Xaa lie Xab Pro Xay 99- Xcw Val Xab Pro Xay ICO. Xaa Val Xbc Pro Xal 101. Xaa Val Xdl Pro Xal 102. Xaa Xdf Xab Pro Xal 103. Xaa lie Xab Pro Xal 104. Xdd Val Xab Pro Xal 105. Xde Val 106. Xcx Val 107. Xcw Val 108. Xcx Val 109. Xcw Val 110. Xcx Val 111. Xcw Val 112. Xcx Val 113. Xab Val 114. Xab Val 115. Xab 'Val 116. Xab Val 117. Xab Val 118. Xab Val 115. Xab Val 120. Xab Val 121. Xab Val 122. Xab Val 123. Xab Val 124. x'ab Val 125. Xab Val 126. Xab Val 127. Xab Val 128. Xaa Val 129. Xaa Val 13 0. Xaa Val 131. Xaa Val 132. Xaa Val 133. Xaa Val 134. Xaa Val 135. Xaa Val 136. Xaa Val 137. Xaa Val 138. Xaa Val 13 9. Xaa Val Xab Pro Xal Xab Pro Xcy Xab Pro Xal Xab Pro Xal Xab Pro Xav Xab Pro Xav Xab Pro Xaw Xab Pro Xaw Xab Pro Xay Xab Pro Xcv Xab Pro Xal Xab Pro Xam Xab Pro Xan Xab Pro Xao Xab Pro Xav Xab Pro Xaw Xab Pro Xat Xab Pro Xau Xab Pro Xbf Xab Pro Xbm Xab Pro Xbn Xab Pro Xbo Xab Pro Xch Xab Pro Xdt Xab Pro Xdu Xab Pro Xdv Xab Pro Xdw Xab pro Xdx Xab Pro Xdy Xab Pro Xdz Xab Pro Xea Xab Pro Xeb Xab pro Xec Xab Pro Xed Xab Pro Xef 140. Xaa Val Xab 141. Xaa Val Xab 142. Xaa Val Xab 143. Xaa Val Xab 144. Xaa Val Xab 145. Xaa Val Xab 14 5. Xaa Val Xab 147. Xaa Val Xab 148. Xaa Val Xab 149. Xaa Val Xab 150. Xaa Val Xab 151. Xaa Val Xab 152. Xaa Val Xab 153 . Xaa Val Xab 154. Xaa Val Xer 155. Xaa Val Xbc 156. Xaa lie Xab 157. Xaa Leu Xab 156. Xdc Val Xab 159. Xdd Val Xab 160. Xes Val Xab 151. Xeu Val Xab 162. Xaa Val X.-b 163. Xaa Val Xab 163. Xaa Val Xab 165. Xaa Val Xab 156. Xaa Val Xab 167. Xaa Val Xab 168. Xaa Val Xab 169. Xdd Val Xab 170. Xaa Xdf Xab 171. Xaa Val Xab 172. Xaa Val Xab 173. Xfa Val Xab 174. Xaa Val Xab Pro Xeg Pro Xeh Pro Xei Pro Xek Pro Xel Pro Xem Pro Ken Pro Xeo Pro Xep Pro Xeq Pro Xer Pro Xcq Pro Pro Val Phe Pro Xet Val Phe NKa Pro Pro Val Phe NH3 Pro Pro Val Phe NH2 Pro Pro Val Phe NH2 Pro Pro Val Phe NH2 Pro Pro Val Phe KH2 Pro Pro Val Phe NH2 Pro Pro Val Phe NH2 Pro Pro Val Phe NH2 Pro Pro Phe Phe NH2 Pro Fio Val NH2 Pro Xev Pro Pro NH2 Pro Pro Pro Xew Xex Pro Pro NH2 Pro Pro NH; Pro Xey Pro Xez Pro Pro Val Phe NH2 Pro Pro Xfb .75 . Xaa Val Xab Pro Xf c .76. Xaa Val Xab pro X£d .77. Xaa Val Xab pro Xfe ,78. Xaa Val Xab Pro Xff L79. Xaa Val Xab Pro Xfg 180. Xaa Val Xab pro Xfh 181. Xaa Val Xab Pro Xfi 182. Xaa Val Xab Pro Xfj 163. Xaa Val Xdl Pro Pro NH; 184. Xia Val Xfk Pro Pro NH2 185. Xaa Val Xfl Pro Xfh 186. Xaa Va^ Xfk Pro Xfh 187. Xcx Val Xab pro Xfh 18 8. Xaa Val Xab Pro Pro Xdf Phe NHS 16 9. Xaa Val Xab Pro Pro Leu Phe NH3 190. Xaa Val Xab Pro Pro lie Phe NHa Examples for the Ms-characterization of the synthesized novel compounds are listed below; EXAMPLE Fast atom bombardment MS analysis 3. 565 4. 579 5. 5 93 6. 607 7. 621 8. 635 11. 607 12. 607 13. 621 14. 649 15. 635 16. 635 17. 635 18 635 19. 621 20. 21. 22. 25. 26. 27. 31. 32. 33. 34. 35. 35. 37. 38. 39. 41. 42. 43 . 44 . 45 . 46. 47. 4 8 . 49. 50. 51. 52. 53. 55. 58. ei. 62. 63. 64. £5 . 621 635 635 633 647 661 623 671 667 681 655 655 669 621 635 649 621 633 £ 66. 67. 68. 69. 70. 71. 72. 74 . 75. 76. 77. 78. 79. 80. 81. 82. S3. B4. 85. 66. 87. 90. 92. 93. 94 . 95. 128 131 139 151 152 153 154 155 156 591 715 685 685 591 607 621 706 579 579 579 607 607 607 607 637 692 705 706 706 607 635 659 617 636 678 671 625 625 637 798 810 812 812 812 hJMMM>-JM!-'HHMMMHI-Jt-'MMMHKH'H!-JH'l--,Hl-'Ht-JHI-'MIOH iDUCDiDCococo(DmctiD)si'j>jvivjv|Ki-j~ivimffimmo\(7:ii\oioi(nuiwtn O^OCO^J^U1if»WNJHOVOCO»JO^UlN'»WUMOU)CD-J(rtLnil»U]tOHOV£l09-J HtJMIJ10JUllJ1Wi(iit»a)K]|--'l--"H The symbols used in the description of the compounds of Formula I have the following meanings: Xaa: N,N-Dimethylvaline Xab: N-Methylvaline / Xda: N-Methyl-2-aminobutyroyl ;:db: S-aminobutyroyl 5 Xdc: N,N-Dimethyl-2-aminobutyroyl Xdd: N,N-Dimethyl~2-tert.butylglycine Xde: N,N-Dimethy1-isoleucine ) Xdf: 2-tert.butylglycine Xer: N-Methy1leucine Xes.- N-Acetyl-N-methylvalin& Xet: pipecolinic acid Xeu: N,N-Dibutylvaline Xfk: N-Ethylvaline Xfl: N-Methyl-3-tert-butylalanine EQUIVALENTS Those skilled in the art will recognize or be able to ascertain using no more than routine experimentation many equivalents to the specific embodiments of the invention 3 described herein. Such equivalents are intended to be encompassed in the scope of the following claims. WE CLAIM : 1. A pharmaceutical composition comprising: an effective amount of a first compound selected from the group consisting of paclitaxel, taxotere and modified taxane or taxoid analogs; and an effective amount of a second compound, wherein the second compound is of Formula I wherein: R1 is alkyl, cycloalkyl, alkylsulfonyl, fluoroalkyl, or aminosulfonyl; R2 is hydrogen, alkyl, fluoroalkyl or cycloalkyl; R1-K-R2 together may be a pyrrolidino or piperidino residue,- A is a valyl, isoleucyl, leucyl, allo-isoleucyl, 2,2-dimethylglycyl, 2-cyclopropylglycyl, 2-cyclopentylglycyl, 3 -tert-butylalanyl, 2-tert-butylglycyl, 3-cyclohexylalanyl, 2-ethylglycyl, 2 -cyclohexylglycyl, norleucyl or norvalyl residue; B is a N-alkyl-valyl, -norvalyl, -leucyl, -isoleucyl, -2-tert-butylglycyl, -3-tert-butylalanyl, -2-ethylglycyl, -2-cyclopropylglycyl, -2-cyclopentylglycyl/ norleucyl or -2-cyclohexylglycyl residue; D is a prolyl, homoprolyl, hydroscyprolyl, 3,4-dehydroprolyl, 4-fluoroprolyl, 3-methylprolyl, 4-methylprolyl, 5-methylprolyl, azetidine-2-carbonyl, 3,3-dimethylprolyl. 4,4-difluoroprolyl, oxazolidine-4-carbonyl or thiazolidine-4-carbonyl residue; E is a prolyl, homoprolyl, hydroxyprolyl, 3,4-dehydroprolyl, 4 -fluoroprolyl, 3 -methylprolyl, 4-methyl prolyl, 5-methylprolyl, azetidine-2-carbonyl, 3,3-dimethylprolyl, 4,4-difluoroprolyl, oxazolidine-4-carbonyl or thiazolidine-4-carbonyl residue; F and G are independently selected from the group consisting of prolyl, homoprolyl, hydroxyprolyl, thiazolidinyl-4-carbonyl, 1-aminopentyl-1-carbonyl, valyl, 2 -tert-butylglycyl, isoleucyl, leucyl, 3-cyclohexylalanyl, phenylalanyl, N-methylphenylalanyl, tetrahydrosioguinolyl-2-histidyl, 1-aminoindyl-l-carbonyl, 3-pyridylalanyl, 2-cyclohexylglycyl, norleucyl, norvalyl, neopentylglycyl, trytophanyl, glycyl, 2,2-dimethylglycyl, alanyl, S-al'anyl and 3-naphthylalanyl residues; X is hydrogen, alkyl, cycloalkyl, -CH2-cyclohexyl or arylalkyl; s, t and u are independently 0 or 1; and K is hydroxy, alkoxy, phenoxy, benzyloxy or a substituted or unsubstituted amino moiety; and the salts thereof with physiologically tolerated aC1ds. 2. The pharmaceutical composition as claimed in claim 1 wherein it comprises a pharmaceutically acceptable carrier. 3 . The composition as claimed in claim 1 wherein for the compound of Formula I, K is a substituted amino moiety having the formula R5-N-R6 wherein: Rs is hydrogen, or hydroxy, or alkoxy, or benzyloxy, or phenyloxy, or linear or branched alkyl (which may be substituted by one or more fluoro atoms), or linear or branched hydroxyalkyl, or C3.10-cycloalkyl, or benzyl (which may be substituted by up to three substituents which may independently be CF3, nitro, cx., alkylsulfonyl, C1 alkoxy, phenoxy, benzoxy, halogen, C1-alkyl, cyano, hydroxy, N(CH3)2, COOMe, COOEt, COOiPr, or COONH2) ; R6 is hydrogen, linear or branched alkyl (which may be sustituted by one or more fluoro atoms), or linear or branched hydroxyalkyl, or C3_10-cycloalkyl, or -{cH2)v- C3.7- cycloalkyl (v=0,l,2, or 3), or norephedryl, or norpseudoephedryl, or quinolyl, or pyrazyl, or -CH2-benzimidazolyl, or (X)-adamantyl or (2)-adamantyl or -CH2-adamantyl, or alpha-methyl-benzyl, or alpha-dime thylbenzyl, or - (CH2)v-phenyl {v-0,1,2, or 3) which may be substituted by up to two substituents which may independently be CF3, nitro, C1ml alkylsulfonyl, C1 alkoxy, phenoxy, benzoxy, halogen, Cj.^-alkyl which may form a cyclic system, cyano, hydroxy, N(CH3)2, COOMe, COOEt, COOiPr, or COONH2) ; or - (CH2)m-naphthyl (m-0 or 1); or - (CH2) v-benzhydryl (w«0,l, or 2); or biphenyl or picolyl or benzothiazolyl or benzoisothiazolyl or benzopyrazolyl or benzoxazolyl or - (CH2JR-fluorenyl {m-0 or 1); or pyrimidyl or - (CH2)m-indanyl (m-0 or 1) ; or - may independently be CF3, nitro, cyano,1 halogen, COOMe, COOEt, COOiPr, CONH2, Cj.,-alkyl, C1-alkoxy, phenyl, benzyl, naphthyl, or Cj.-j-alkylsulfonyl [R7 ■ hydrogen, linear or branched C1 alkyl, benzyl; or R7 and R5 together form a group -(CHa)3- or -(CHa)4-). 4 . ThecomPosition as claimed in claim 3 wherein for the compound of Formula I R1 and R* are each methyl or ethyl; X is isopropyl, sec-butyl or tert-butyl; s is 1; t and u are each 0; A is valyl, isoleucyl or 2-tert-butylglycyl; B is N-methylvalyl, 1-isoleucyl or 2-tertbutylglycyl; D is prolyl, thiazolidinyl--4-carbonyl, or 3,4-dehydroprolyl; E is prolyl, thiazolidinyl-4-carbonyl, homoprolyl, 3,4-dehydroprolyl or hydroxyprolyl; and K is a substituted amino moiety having the formula R--N-R* wherein R5 is hydrogen or C1-C4 alkoxy and RG is a Cj,-Cl2 linear or branched alkyl group selected from the group of monovalent radicals consisting of: -C(CH3)3, also referred to as tert-butyl; -p-CH2-CH3, also referred to as 1,1-dimethyl propyl; -C(CH2-CH3)3, also referred to as 1-methyl-l-ethyl CH3 propyl -CH-C(CH3)3, also referred to as (s) - or (R)-i-methyl-CH3 2,2-dimethyl propyl; -pH-CH(CH3)2, also referred to as (S) - or (R)-l-ethyl-C2HS 2-methyl propyl; 'CH-CH(CH3)j, also referred to as l-isopropyl-2-methyl CH(CH3)3 butyl; or -C(CH3)2-CH(CH3)2, also referred to as 1,l-dimethyl-2-methylpropyl -CH{CH3)2, also referred to as isopropyl -CH(CH3)CH2CH3, also referred to as sec-butyl, (S) - or (R>- ~CH(CH-)CH{CH3)., also referred to as 1,2- dimethylpropyl. 5 . The composition as claimed in claim 4 wherein the monovalent radical is -C(CH3)3, also referred to as tert-butyl. 6 . The composition as claimed in claim 3 wherein forthe compound of Formula I R1 and R3 are each methyl or ethyl; X is isopropyl, sec-butyl or tert-butyl; s is 1; t and u are each 0; A is valyl, isoleucyl or 2-tert-butylglycyl; B is N-methylvalyl, 1-isoleucyl or 2-tertbutylglycyl; D is prolyl, thiazolidinyl-4-carbonyl, or 3,4-dehydroprolyl; E is prolyl, thiazolidinyl-4-carbonyl, homoprolyl, 3,4-dehydroprolyl or hydroxyprolyl; and K is a substituted amino moiety having the formula R5-N-Rs wherein R5 is hydrogen or C1C4 alkoxy and Rs is selected from the group of monovalent radicals consisting of: (CH2)v-phenyl (wherein v is 1) and a,a-dimethylbenzyl. 1 ■ The composition as claimed in claim 3 wherein for the compound of Formula I R* and R2 are each methyl or ethyl; X is isopropyl, sec-butyl or tert-butyl; s is 1; t and u are each 0; A is valyl, isoleucyl or 2-tert-butylglycyl; B is N-methylvalyl, 1-isoleucyl or 2-tertbutylglycyl; D is prolyl, thiazolidinyl-4-carbonyl, or 3,4-de^hydroprolyl; E is prolyl, thiazolidinyl-4-cajjbonyl, homoprolyl, 3,4-dehydroprolyl or h.ydroxyprolyl; and K is a substituted amino moiety having the formula Rs-N-Rs wherein R5 is hydrogen or CjC4 alkoxy and R6 is a Cj-Cl2 linear or branched hydroxyalkyl. 8. The composition asclaimedin Claim 7 wherein Re is 3-hydroxy-L,1- dimethylpropyl. 9 • The composition as claimed in claim 3 wherein for the compound of Formula I R1 and R* are each methyl or ethyl; x is isopropyl, sec-butyl or tert-butyl; s is l; t and u are each 0; A is valyl, isoleucyl or 2-tert-butylglycyl; B is N-methylvalyl, l-isoleucyl or 3-tertbutylglycyl; D is prolyl, thiazolidinyl-4-carbonyl, or 3,4-dehydroprolyl; E is prolyl, thiazolidinyl-4-carbonyl, homoprolyl, 3,4-dehydroprolyl or hydroxyprolyl; and K is a substituted amino moiety having the fcrtnula Rs-N-R6 wherein Rs is hydrogen or alkoscy and R6 is a C3. 10 cycloalkyl selected from the group consisting of: (1) -adamantyl, (2) -adamantyl, cyclobutyl, cyclopentyl, cyclohexyl, 1-methylcyclopentyl, l-methylcyclohexyl and [3.3.0]octa-l-yl. 10, The composition as claimed in claim 3 wherein forthe compound of Formula I R1 and R! are each methyl; X is isopropyl; s is i; t and u are each 0; A is valyl; B is N-methylvalyl; D is prolyl; E is prolyl; R5 is benzyl and R6 is hydrogen. WE CLAIM : 1. A pharmaceutical composition comprising: an effective amount of a first compound selected from the group consisting of paclitaxel, taxotere and modified taxane or taxoid analogs; and an effective amount of a second compound, wherein the second compound is of Formula I wherein: R1 is alkyl, cycloalkyl, alkylsulfonyl, fluoroalkyl, or aminosulfonyl; R2 is hydrogen, alkyl, fluoroalkyl or cycloalkyl; R1-K-R2 together may be a pyrrolidino or piperidino residue,- A is a valyl, isoleucyl, leucyl, allo-isoleucyl, 2,2-dimethylglycyl, 2-cyclopropylglycyl, 2-cyclopentylglycyl, 3 -tert-butylalanyl, 2-tert-butylglycyl, 3-cyclohexylalanyl, 2-ethylglycyl, 2 -cyclohexylglycyl, norleucyl or norvalyl residue; B is a N-alkyl-valyl, -norvalyl, -leucyl, -isoleucyl, -2-tert-butylglycyl, -3-tert-butylalanyl, -2-ethylglycyl, -2-cyclopropylglycyl, -2-cyclopentylglycyl/ norleucyl or -2-cyclohexylglycyl residue; D is a prolyl, homoprolyl, hydroscyprolyl, 3,4-dehydroprolyl, 4-fluoroprolyl, 3-methylprolyl, 4-methylprolyl, 5-methylprolyl, azetidine-2-carbonyl, 3,3-dimethylprolyl. 4,4-difluoroprolyl, oxazolidine-4-carbonyl or thiazolidine-4-carbonyl residue; E is a prolyl, homoprolyl, hydroxyprolyl, 3,4-dehydroprolyl, 4 -fluoroprolyl, 3 -methylprolyl, 4-methyl prolyl, 5-methylprolyl, azetidine-2-carbonyl, 3,3-dimethylprolyl, 4,4-difluoroprolyl, oxazolidine-4-carbonyl or thiazolidine-4-carbonyl residue; F and G are independently selected from the group consisting of prolyl, homoprolyl, hydroxyprolyl, thiazolidinyl-4-carbonyl, 1-aminopentyl-1-carbonyl, valyl, 2 -tert-butylglycyl, isoleucyl, leucyl, 3-cyclohexylalanyl, phenylalanyl, N-methylphenylalanyl, tetrahydrosioguinolyl-2-histidyl, 1-aminoindyl-l-carbonyl, 3-pyridylalanyl, 2-cyclohexylglycyl, norleucyl, norvalyl, neopentylglycyl, trytophanyl, glycyl, 2,2-dimethylglycyl, alanyl, S-al'anyl and 3-naphthylalanyl residues; X is hydrogen, alkyl, cycloalkyl, -CH2-cyclohexyl or arylalkyl; s, t and u are independently 0 or 1; and K is hydroxy, alkoxy, phenoxy, benzyloxy or a substituted or unsubstituted amino moiety; and the salts thereof with physiologically tolerated aC1ds. 2. The pharmaceutical composition as claimed in claim 1 wherein it comprises a pharmaceutically acceptable carrier. 3 . The composition as claimed in claim 1 wherein for the compound of Formula I, K is a substituted amino moiety having the formula R5-N-R6 wherein: Rs is hydrogen, or hydroxy, or alkoxy, or benzyloxy, or phenyloxy, or linear or branched alkyl (which may be substituted by one or more fluoro atoms), or linear or branched hydroxyalkyl, or C3.10-cycloalkyl, or benzyl (which may be substituted by up to three substituents which may independently be CF3, nitro, cx., alkylsulfonyl, C1 alkoxy, phenoxy, benzoxy, halogen, C1-alkyl, cyano, hydroxy, N(CH3)2, COOMe, COOEt, COOiPr, or COONH2) ; R6 is hydrogen, linear or branched alkyl (which may be sustituted by one or more fluoro atoms), or linear or branched hydroxyalkyl, or C3_10-cycloalkyl, or -{cH2)v- C3.7- cycloalkyl (v=0,l,2, or 3), or norephedryl, or norpseudoephedryl, or quinolyl, or pyrazyl, or -CH2-benzimidazolyl, or (X)-adamantyl or (2)-adamantyl or -CH2-adamantyl, or alpha-methyl-benzyl, or alpha-dime thylbenzyl, or - (CH2)v-phenyl {v-0,1,2, or 3) which may be substituted by up to two substituents which may independently be CF3, nitro, C1ml alkylsulfonyl, C1 alkoxy, phenoxy, benzoxy, halogen, Cj.^-alkyl which may form a cyclic system, cyano, hydroxy, N(CH3)2, COOMe, COOEt, COOiPr, or COONH2) ; or - (CH2)m-naphthyl (m-0 or 1); or - (CH2) v-benzhydryl (w«0,l, or 2); or biphenyl or picolyl or benzothiazolyl or benzoisothiazolyl or benzopyrazolyl or benzoxazolyl or - (CH2JR-fluorenyl {m-0 or 1); or pyrimidyl or - (CH2)m-indanyl (m-0 or 1) ; or - may independently be CF3, nitro, cyano,1 halogen, COOMe, COOEt, COOiPr, CONH2, Cj.,-alkyl, C1-alkoxy, phenyl, benzyl, naphthyl, or Cj.-j-alkylsulfonyl [R7 ■ hydrogen, linear or branched C1 alkyl, benzyl; or R7 and R5 together form a group -(CHa)3- or -(CHa)4-). 4 . ThecomPosition as claimed in claim 3 wherein for the compound of Formula I R1 and R* are each methyl or ethyl; X is isopropyl, sec-butyl or tert-butyl; s is 1; t and u are each 0; A is valyl, isoleucyl or 2-tert-butylglycyl; B is N-methylvalyl, 1-isoleucyl or 2-tertbutylglycyl; D is prolyl, thiazolidinyl--4-carbonyl, or 3,4-dehydroprolyl; E is prolyl, thiazolidinyl-4-carbonyl, homoprolyl, 3,4-dehydroprolyl or hydroxyprolyl; and K is a substituted amino moiety having the formula R--N-R* wherein R5 is hydrogen or C1-C4 alkoxy and RG is a Cj,-Cl2 linear or branched alkyl group selected from the group of monovalent radicals consisting of: -C(CH3)3, also referred to as tert-butyl; -p-CH2-CH3, also referred to as 1,1-dimethyl propyl; -C(CH2-CH3)3, also referred to as 1-methyl-l-ethyl CH3 propyl -CH-C(CH3)3, also referred to as (s) - or (R)-i-methyl-CH3 2,2-dimethyl propyl; -pH-CH(CH3)2, also referred to as (S) - or (R)-l-ethyl-C2HS 2-methyl propyl; 'CH-CH(CH3)j, also referred to as l-isopropyl-2-methyl CH(CH3)3 butyl; or -C(CH3)2-CH(CH3)2, also referred to as 1,l-dimethyl-2-methylpropyl -CH{CH3)2, also referred to as isopropyl -CH(CH3)CH2CH3, also referred to as sec-butyl, (S) - or (R>- ~CH(CH-)CH{CH3)., also referred to as 1,2- dimethylpropyl. 5 . The composition as claimed in claim 4 wherein the monovalent radical is -C(CH3)3, also referred to as tert-butyl. 6 . The composition as claimed in claim 3 wherein forthe compound of Formula I R1 and R3 are each methyl or ethyl; X is isopropyl, sec-butyl or tert-butyl; s is 1; t and u are each 0; A is valyl, isoleucyl or 2-tert-butylglycyl; B is N-methylvalyl, 1-isoleucyl or 2-tertbutylglycyl; D is prolyl, thiazolidinyl-4-carbonyl, or 3,4-dehydroprolyl; E is prolyl, thiazolidinyl-4-carbonyl, homoprolyl, 3,4-dehydroprolyl or hydroxyprolyl; and K is a substituted amino moiety having the formula R5-N-Rs wherein R5 is hydrogen or C1C4 alkoxy and Rs is selected from the group of monovalent radicals consisting of: (CH2)v-phenyl (wherein v is 1) and a,a-dimethylbenzyl. 1 ■ The composition as claimed in claim 3 wherein for the compound of Formula I R* and R2 are each methyl or ethyl; X is isopropyl, sec-butyl or tert-butyl; s is 1; t and u are each 0; A is valyl, isoleucyl or 2-tert-butylglycyl; B is N-methylvalyl, 1-isoleucyl or 2-tertbutylglycyl; D is prolyl, thiazolidinyl-4-carbonyl, or 3,4-de^hydroprolyl; E is prolyl, thiazolidinyl-4-cajjbonyl, homoprolyl, 3,4-dehydroprolyl or h.ydroxyprolyl; and K is a substituted amino moiety having the formula Rs-N-Rs wherein R5 is hydrogen or CjC4 alkoxy and R6 is a Cj-Cl2 linear or branched hydroxyalkyl. 8. The composition asclaimedin Claim 7 wherein Re is 3-hydroxy-L,1- dimethylpropyl. 9 • The composition as claimed in claim 3 wherein for the compound of Formula I R1 and R* are each methyl or ethyl; x is isopropyl, sec-butyl or tert-butyl; s is l; t and u are each 0; A is valyl, isoleucyl or 2-tert-butylglycyl; B is N-methylvalyl, l-isoleucyl or 3-tertbutylglycyl; D is prolyl, thiazolidinyl-4-carbonyl, or 3,4-dehydroprolyl; E is prolyl, thiazolidinyl-4-carbonyl, homoprolyl, 3,4-dehydroprolyl or hydroxyprolyl; and K is a substituted amino moiety having the fcrtnula Rs-N-R6 wherein Rs is hydrogen or alkoscy and R6 is a C3. 10 cycloalkyl selected from the group consisting of: (1) -adamantyl, (2) -adamantyl, cyclobutyl, cyclopentyl, cyclohexyl, 1-methylcyclopentyl, l-methylcyclohexyl and [3.3.0]octa-l-yl. 10, The composition as claimed in claim 3 wherein forthe compound of Formula I R1 and R! are each methyl; X is isopropyl; s is i; t and u are each 0; A is valyl; B is N-methylvalyl; D is prolyl; E is prolyl; R5 is benzyl and R6 is hydrogen.

Documents:

508-mas-1998 abstract duplicate.pdf

508-mas-1998 abstract.pdf

508-mas-1998 claims duplicate.pdf

508-mas-1998 claims.pdf

508-mas-1998 correspondence others.pdf

508-mas-1998 correspondence po.pdf

508-mas-1998 description (complete) duplicate-1.pdf

508-mas-1998 description (complete) duplicate.pdf

508-mas-1998 description (complete)-1.pdf

508-mas-1998 description (complete).pdf

508-mas-1998 drawings duplicate.pdf

508-mas-1998 form-1.pdf

508-mas-1998 form-13.pdf

508-mas-1998 form-19.pdf

508-mas-1998 form-26.pdf

508-mas-1998 form-4.pdf

508-mas-1998 form-6.pdf

508-mas-1998 petiiton.pdf