Title of Invention	"A PROCESS FOR THE PREPARATION OF A NEUTRALIZING AGENT FOR NEUTRALIZING TOXIC EFFECTS OF TOXIC ORGANOPHOSPHOROUS AND ORGANO-SULFUR-CHLORINE COMPOUNDS"
Abstract	A process for the preparation of a neutralising agent for neutralising toxic effects of toxic organophosphorous and organo-sulfur-chlorine compounds comprising of the steps of : a) preparing a first solution of oil, surfactant, alcohol, monoethyalamine, ethenediol, sequestrine, and water in the ratio of 4:4:5:15:1:2:1 respectively and mixed with each other, . b) prebarinq a second solution of 0,1% alkaline solution in water and then c) mixing said first and second solutions in the ratio of 1:1 to obtain the decontaminating or neutralizing agent.

Title of Invention

"A PROCESS FOR THE PREPARATION OF A NEUTRALIZING AGENT FOR NEUTRALIZING TOXIC EFFECTS OF TOXIC ORGANOPHOSPHOROUS AND ORGANO-SULFUR-CHLORINE COMPOUNDS"

Abstract

A process for the preparation of a neutralising agent for neutralising toxic effects of toxic organophosphorous and organo-sulfur-chlorine compounds comprising of the steps of : a) preparing a first solution of oil, surfactant, alcohol, monoethyalamine, ethenediol, sequestrine, and water in the ratio of 4:4:5:15:1:2:1 respectively and mixed with each other, . b) prebarinq a second solution of 0,1% alkaline solution in water and then c) mixing said first and second solutions in the ratio of 1:1 to obtain the decontaminating or neutralizing agent.

Full Text	This invention relates to a process for the preparation of a neutralizing agent for neutralizing tonic effects of toxic organophosphorous and organo- sulfur—chlorine compounds and their formulations 'specially, but. without implying any limitation toxic organophosphorous compounds containing, either or all of the four elements Fluorine;, Oxygen, Phosphorous and Sulfur and 'organo sulfur chlorine compound: such as b.is(2—Chloroethyl ) sulfide and related structure?©. Hany of the organophosphorous compounds are known as potential insecticides, fungicides and chemical warfare agents. These compounds affect the human body through inhalation, contact and oral routes- Some of the compounds like cyanofenphos, leptophos, which are earlier used as effective insecticides,, have since been banned as these have been found to cause Organophosphorous Induced Delayed Neuropathy Generally, preventive measure are recommended to avoid touching or inhalation of the preparations of the organophosphorous compounds. For this purpose, farmers, etc. who use/handle the imsecticxdal compounds are advised to use hand, glove® or face piece to avoid the toxic effects of these chemicals. The empty containers of these chemicals, are generally cleaned before discarding to avoid re-use by any person ignorant of the toxic effects of these chemicals. The contamination with organophosphorous based chemicals can also occur due to leakage/spillage while producing, storage or transportation of these chemicals. In case of contamination with highly toxic organophosphorous compounds such as O-diisopropylmethylphosphonofluoridate and o-ethyl S-(2-diisopropylamino) ethyl methyl phosphonothiolate etc. the body of the individual must be protected completely to avoid health hazards. However, many of the organophosphorous based formulations are generally insoluble in water. Therefore, residual toxic effect of organophosphorous based insecticides etc. cannot be completely detoxified by mere washing with water or even washing with soapy water. Any re-use of empty containers of organophosphorous based insecticides/fungicides etc. by any ignorant person can therefore cause him health-hazard. Similarly, any metal, wooden, fabric or plastic surface which gets contaminated due to contact with these compounds cannot be fully'de-toxified by washing with water or detergents. Therefore, there is a need for a chemical formulation which can completely de-toxify any surface/container from the residual toxic effects of the organophosphorous based insecticides, fungicides or highly toxic organophosphorous compounds. Alkaline solutions are known in the art to be used for neutralising the residual toxic-effect of the organophosphorous chemicals. One of the disadvantages of the use of strong alkaline solution for neutralising the residual toxic effects of the organophosphorous chemicals is that alkali has harmful effect on the human skin and easy washing with water is difficult. Another disadvantage of the use of strong alkaline solution is that it corrodes the metal containers and also affects the wooden surface. Another neutralising formulation known in the art is Miceller solution which is prepared by a process involving of mixing surfactant and water followed by additon of alkali. However, on of the drawbacks of the miceller solution is that it has ppor solubilising property due to which it is not very effective and is very slow-acting in neutralising specially organo-sulfur-chlorine compounds. Besides, it does not dissolve some of the organophosphorous compounds. Another limitation /of the miceller solution is that it is unsuitable for use at low temperatures, as even at 10 C its ingredients tend to precipitate out. According to another process known in the art, RM solutions are prepared and used for neutralising residual toxic effects of organophosphorous compounds. The main disadvantage of the above solution is that RM cleaning agents are to be used as an admixture with oxidizing agent (e.g. bleaching powder) for complete decontamination of the toxic organosulfur chlorine compounds, as the use of single solution does not give effective detoxiffcation of the contaminated sufface. According to Miceller process known in the art, the process provides formulation comprising of alkali and surfactant. This formulation has also the drawback of not much effective as it does not solubilise all toxic agents and due to which it is slow in neutralising the organophosphorous as well as organo-sulfur-chlorine compounds. The primary object of the present invention is to propose a process for preparation of a decontaminating or neutralizing agent for neutralising toxic organophosphorous as well as as organo-sulfur chlorine chemicals so as to de-toxify any contaminated metal, wooden, fabric or plastic surface to protect against the residual toxic effects of these chemicals. Another object of the present invention is to propose a process for the preparation of a decontaminating or neutralizing agent which is capable of decontamination/neutralisation of extremely toxic organophosphorous based chemicals containing either or all of the four elements namely Fluorine, Oxygen, Phosphorous and sulfur. For this simple reason this formulation is rightly referred to as FOPS decontamination solution. Still another object of the present invention is to propose a process for the preparation a decontaminating or neutralizing agent which is also effective against highly toxic/delayed neurotoxic organophosphorous compounds like di-isopropyl phosphorofluoridate, ethyl pnitrophenyl phosphorothionate etc. A further object of the present invention is to propose a process for the preparation a decontaminating or neutralizing agent which provides detoxification of surfaces contaminated with organo-sulfur-chlorine compounds e.g., Bis {2-chloroethyl) sulfide and compounds of similar structures. A still further object of the present invention is to propose a process for the preparation of a decontaminating or neutralizing agent which is a ready to use solution for detoxification of surfaces contaminated with toxic organophosphorous chemicals, i.e. the solution not requiring even preliminary processing like dissolution or dilution. Yet. still a further object of the present invention is to propose a process for the preparation of a decontaminating or neutralizing agent which is non-corrosive to metal/wooden surfaces and is safer to handle. Yet still another object of the present invention is to provide a process for preparation of a decontaminating or neutralizing agent which has a lower freezing point thereby enabling the use of the solution of low-temperatures in colder regions. Yet another object of the present invention is to propose a process for the preparation of a decontaminating or neutralising agent which can also be used at. the site of decontamination in bulk quantities within a short notice, thereby obviating the need for storage of huge dump of these chemicals, transportation and delivery of the decontaminating solutions to the area of contamination,, Ac.cctrd.ing to this invention there is provided a process for the preparation of a decontaminating or neutralising agent comprising of the steps of : a) preparing a first solution of oil, surfactant, alcohol, monoethalamine, ethenediol, . sequestrine, and water in the ratio of 4:4;5;15:1:1:2:1 respectively and mixed with each other, fa) preparing a second solution of 0,1% alkaline solution in water and then c) mixing said first and second solutions in the ratio of 1:1 to obtain the decontaminating or neutra1izingagent. In accordance with the present invention a first solution is prepared by mixing of oil, surfactant, alcohol, monoethanolamine, ethenediol, sequestrrne. and water in the ratio of 4:4:5 :15 :1:1: 2:1 The oil taken may be cyclic/acyclic hydrocarbon or chlorinated hydrocarbon e.g. tetrachloroethylene. The alcohol may be represented as CnH2n+1OH(n = 4 to .6) . A 0.1% alkaline second solution is prepared in water. The first and second I solutions are then mixed in ratio of 1:1 with stirring to obtain the required decontaminating or neutralizing agent. Further in accordance with the present invention for preparation in bulk amounts of the decontaminating or neutralizing agent/ the first and second solutions prepared as described above are charged in separate compartments of" a mobile decontamination system, the second, tsolution obtained in as described above is flown at equal rates and is alloWed to mix to obtain the desired composttion. The first solution may be stored separately and diluted only at the time of its use. Thus it would solve. The proposed formulation in addition to surfactant and alkaline solution (0.020 M) in water known in the art, incorporates additional chemical sonstituents namely alcohol (CnH2n+lOH with n = 4 to 6), monoethanolamine, oil which may be cyclic/acyclic hydrocarbon or chlorinated hydrocarbon like Tetrachloroethylene antifreezing chemical (e.g. ethylene glycol) and sequestering agent (HICO -Metclaw ) for softening the hard water. . The additional constituents have synergic effects in the overall composition of the proposed formulation, Firstly, the proposed composition of the invention provides a single solution for neutralising all types of organophosphorous and organosuffur chlorine based chemicals like insecticides fungicides and also the chemicals of warfare status, Secondly, the additi©nal; \ constituents enhance the solubilising water and softening property of the proposed neutralising formulation thereby improving greatly the efficacy of the solution in terms of de-toxification against residual toxic effects of toxic/highly toxic/delayed neurotoxic organophosphorous based chemicals/formulations. Thirdly, the additional constituents • in the proposed improved composition result in a compostition with lower freezing point thereby extending the use of the solutions in the colder regions as compared to the solutions known in the o art in which ingredients separate out even at IOC. Fourthly, the addition of monoethanolamine to the proposed composition results in imparting the composition an additional and special property of neutralising the toxic organo-sulfur-chlorine compounds. The monoethanolamine reacts- with bis (2-chloroethyl) sulfide and forms comparatively lesser toxic products. This method has potential to find an application for decontamination of bulk quantities of chemicals. The invention will now be illustrated but not limited by the following examples:- EXAMPLE; l.Og Sodium hydroxide is dissolved in 600 ml of water and is added to a mixture of oil (80ml), surfactant (80g), Butanol (100-120 ml), monoethanolamine (300ml), Ethananediol (20ml) and Metclaw (20ml). PRECAUTION: The composite mixture is harmful to eyes hence direct contact must be avoided. In case of eyes coming in direct contact, wash thoroughly with water. I CLAIM : 1. A process for the preparation of a neutralizing agent for neutralising toxic effects of toxic organophosphorous and organo-su1 fur-chlorine compounds comprising" of the steps of s a) preparing a first solution of oil, surfactant, alcohol, monoethyalafnine, ethenedioi f sequestrine, and water in the ratio of 4:4:5:15:1;1:2:1 respectively and mixed with each other, h> preparing a second solution of 0.1% alkaline solution in water and then c) mixing said' first, and second solutions in the ratio of 1:1 to obtain the decontaminating or neutralizing agent. 2. A process as, claimed in claim 1, wherein said oil is cylic/acylic hydrocarbon, chlorinated hydrocarbon e.g. tetrachloroethylene. 3. A process as claimed in claim 1 wherein said alcohol is represented by the formula as C. H2n+1,0H(n=4 to 6) 4. A process for the preparation of a decontaminating or neutralising agent substantially as herein described and illustrated.

Full Text

This invention relates to a process for the
preparation of a neutralizing agent for neutralizing tonic effects of toxic organophosphorous and organo-
sulfur—chlorine compounds and their formulations 'specially, but. without implying any limitation toxic
organophosphorous compounds containing, either or all of the four elements Fluorine;, Oxygen, Phosphorous and
Sulfur and 'organo sulfur chlorine compound: such as b.is(2—Chloroethyl ) sulfide and related structure?©.
Hany of the organophosphorous compounds are known as potential insecticides, fungicides and
chemical warfare agents. These compounds affect the human body through inhalation, contact and oral routes-
Some of the compounds like cyanofenphos, leptophos, which are earlier used as effective insecticides,, have
since been banned as these have been found to cause Organophosphorous Induced Delayed Neuropathy Generally, preventive measure are recommended to avoid touching or inhalation of the preparations of
the organophosphorous compounds. For this purpose, farmers, etc. who use/handle the imsecticxdal compounds
are advised to use hand, glove® or face piece to avoid the toxic effects of these chemicals. The empty
containers of these chemicals, are generally cleaned
before discarding to avoid re-use by any person ignorant of the toxic effects of these chemicals. The contamination with organophosphorous based chemicals can also occur due to leakage/spillage while producing, storage or transportation of these chemicals. In case of contamination with highly toxic organophosphorous compounds such as O-diisopropylmethylphosphonofluoridate and o-ethyl S-(2-diisopropylamino) ethyl methyl phosphonothiolate etc. the body of the individual must be protected completely to avoid health hazards.
However, many of the organophosphorous based formulations are generally insoluble in water. Therefore, residual toxic effect of organophosphorous based insecticides etc. cannot be completely detoxified by mere washing with water or even washing with soapy water. Any re-use of empty containers of organophosphorous based insecticides/fungicides etc. by any ignorant person can therefore cause him health-hazard. Similarly, any metal, wooden, fabric or plastic surface which gets contaminated due to contact with these compounds cannot be fully'de-toxified by washing with water or detergents. Therefore, there is a need for a
chemical formulation which can completely de-toxify any surface/container from the residual toxic effects
of the organophosphorous based insecticides, fungicides or highly toxic organophosphorous compounds.
Alkaline solutions are known in the art to be
used for neutralising the residual toxic-effect of the organophosphorous chemicals.
One of the disadvantages of the use of strong alkaline solution for neutralising the
residual toxic effects of the organophosphorous chemicals is that alkali has harmful effect on the human skin and easy washing with water is difficult.
Another disadvantage of the use of strong alkaline solution is that it corrodes the metal containers and also affects the wooden surface.
Another neutralising formulation known in the art is Miceller solution which is prepared by a process involving of mixing surfactant
and water followed by additon of alkali.
However, on of the drawbacks of the miceller solution is that it has ppor solubilising property due to which it is not very effective and is very slow-acting in neutralising specially organo-sulfur-chlorine compounds. Besides, it does not dissolve some of the organophosphorous compounds.
Another limitation /of the miceller solution is that it is unsuitable for use at low temperatures, as even at 10 C its ingredients tend to precipitate out.
According to another process known in the art, RM solutions are prepared and used for
neutralising residual toxic effects of organophosphorous compounds.
The main disadvantage of the above solution is that RM cleaning agents are to be used as an admixture with oxidizing agent (e.g. bleaching powder) for complete decontamination of the toxic organosulfur chlorine compounds, as the use of single solution does not give effective detoxiffcation of the contaminated sufface.
According to Miceller process known in the art, the process provides formulation comprising of alkali and surfactant. This formulation has also the drawback of not much effective as it does not solubilise all toxic agents and due to which it is slow in neutralising the organophosphorous as well as organo-sulfur-chlorine compounds.
The primary object of the present invention is to propose a process for preparation of a decontaminating or neutralizing agent for neutralising toxic organophosphorous as well
as as organo-sulfur chlorine chemicals so as to de-toxify any contaminated metal, wooden,
fabric or plastic surface to protect against the residual toxic effects of these chemicals.
Another object of the present invention is to propose a process for the preparation of a decontaminating
or neutralizing agent which is capable of decontamination/neutralisation of extremely toxic organophosphorous based chemicals containing either or all of the four elements namely Fluorine, Oxygen, Phosphorous and sulfur. For this simple reason this formulation is rightly referred to as FOPS decontamination solution.
Still another object of the present invention
is to propose a process for the preparation a decontaminating or neutralizing agent which
is also effective against highly toxic/delayed neurotoxic organophosphorous compounds like di-isopropyl phosphorofluoridate, ethyl pnitrophenyl phosphorothionate etc.
A further object of the present invention is to propose a process for the preparation a decontaminating or neutralizing agent which provides detoxification of surfaces contaminated with organo-sulfur-chlorine compounds e.g., Bis {2-chloroethyl) sulfide and compounds of similar structures.
A still further object of the present invention is to propose a process for the preparation of a decontaminating or neutralizing agent which is a ready to use solution for detoxification of surfaces contaminated with toxic organophosphorous chemicals, i.e. the solution not requiring even preliminary processing like dissolution or dilution.
Yet. still a further object of the present invention is to propose a process for the preparation of a decontaminating or neutralizing agent which is non-corrosive to metal/wooden surfaces and is safer to handle.
Yet still another object of the present invention
is to provide a process for preparation of a decontaminating or neutralizing agent which has a lower
freezing point thereby enabling the use of the solution of low-temperatures in colder regions.
Yet another object of the present invention is to propose a process for the preparation of a
decontaminating or neutralising agent which can also be used at. the site of decontamination in bulk quantities
within a short notice, thereby obviating the need for storage of huge dump of these chemicals, transportation
and delivery of the decontaminating solutions to the area of contamination,,
Ac.cctrd.ing to this invention there is provided
a process for the preparation of a decontaminating or neutralising agent comprising of the steps of :
a) preparing a first solution of oil, surfactant, alcohol, monoethalamine, ethenediol, . sequestrine, and
water in the ratio of 4:4;5;15:1:1:2:1 respectively and mixed with each other, fa) preparing a second solution of 0,1% alkaline
solution in water and then c) mixing said first and second solutions in the
ratio of 1:1 to obtain the decontaminating or neutra1izingagent.
In accordance with the present invention a first solution is prepared by mixing of oil, surfactant, alcohol, monoethanolamine, ethenediol, sequestrrne. and water in the ratio of 4:4:5 :15 :1:1: 2:1 The oil taken may be
cyclic/acyclic hydrocarbon or chlorinated hydrocarbon e.g. tetrachloroethylene. The alcohol may be represented as CnH2n+1OH(n = 4 to .6) . A 0.1% alkaline second
solution is prepared in water. The first and second I solutions are then mixed in ratio of 1:1 with
stirring to obtain the required decontaminating
or neutralizing agent.
Further in accordance with the present invention
for preparation in bulk amounts of the decontaminating or neutralizing agent/ the first and second
solutions prepared as described above are charged
in separate compartments of" a mobile decontamination
system, the second, tsolution obtained in as
described above is flown at equal rates and is
alloWed to mix to obtain the desired composttion.
The first solution may be stored separately
and diluted only at the time of its use. Thus it would solve.
The proposed formulation in addition to surfactant and alkaline solution (0.020 M) in water known in the art, incorporates additional chemical sonstituents namely alcohol (CnH2n+lOH with n = 4 to 6), monoethanolamine, oil which may be cyclic/acyclic hydrocarbon or chlorinated hydrocarbon like Tetrachloroethylene antifreezing chemical (e.g. ethylene glycol) and sequestering agent (HICO -Metclaw ) for softening the hard
water. . The additional constituents have synergic effects in the overall composition of the proposed
formulation, Firstly, the proposed composition of the invention provides a single solution for neutralising all types of organophosphorous and
organosuffur chlorine based chemicals like insecticides fungicides and also the chemicals of warfare status, Secondly, the additi©nal; \ constituents enhance the solubilising water and softening property of the proposed neutralising formulation thereby improving greatly the efficacy of the solution in terms of de-toxification against residual toxic effects of toxic/highly toxic/delayed neurotoxic organophosphorous based chemicals/formulations.
Thirdly, the additional constituents • in the proposed improved composition result in a compostition with lower freezing point thereby extending the use of the solutions in the colder
regions as compared to the solutions known in the
o art in which ingredients separate out even at IOC.
Fourthly, the addition of monoethanolamine to the proposed composition results in imparting
the composition an additional and special property of neutralising the toxic organo-sulfur-chlorine compounds. The monoethanolamine reacts- with bis (2-chloroethyl) sulfide and forms comparatively lesser toxic products. This method has potential to find an application for decontamination of bulk quantities of chemicals.
The invention will now be illustrated but not limited by the following examples:-
EXAMPLE;
l.Og Sodium hydroxide is dissolved in 600 ml
of water and is added to a mixture of oil (80ml), surfactant (80g), Butanol (100-120 ml), monoethanolamine
(300ml), Ethananediol (20ml) and Metclaw (20ml). PRECAUTION: The composite mixture is harmful to eyes hence direct contact must be avoided. In case of eyes coming in direct contact, wash thoroughly with water.

I CLAIM :
1. A process for the preparation of a neutralizing
agent for neutralising toxic effects of toxic

organophosphorous and organo-su1 fur-chlorine compounds
comprising" of the steps of s a) preparing a first solution of oil, surfactant,
alcohol, monoethyalafnine, ethenedioi f sequestrine, and water in the ratio of 4:4:5:15:1;1:2:1 respectively and
mixed with each other, h> preparing a second solution of 0.1% alkaline
solution in water and then c) mixing said' first, and second solutions in the
ratio of 1:1 to obtain the decontaminating or neutralizing agent.
2. A process as, claimed in claim 1, wherein said oil
is cylic/acylic hydrocarbon, chlorinated hydrocarbon
e.g. tetrachloroethylene.
3. A process as claimed in claim 1 wherein said
alcohol is represented by the formula as C. H2n+1,0H(n=4
to 6)
4. A process for the preparation of a decontaminating
or neutralising agent substantially as herein described
and illustrated.

Documents:

1053-del-1996-abstract.pdf

1053-del-1996-claims.pdf

1053-del-1996-complete specification (granted).pdf

1053-del-1996-correspondence-others.pdf

1053-del-1996-correspondence-po.pdf

1053-del-1996-description (complete).pdf

1053-del-1996-form-1.pdf

1053-del-1996-form-2.pdf

1053-del-1996-form-4.pdf

1053-del-1996-gpa.pdf

« Previous Patent

Next Patent »

Patent Number

232983

Indian Patent Application Number

1053/DEL/1996

PG Journal Number

13/2009

Publication Date

27-Mar-2009

Grant Date

24-Mar-2009

Date of Filing

20-May-1996

Name of Patentee

THE CHIEF CONTROLLER RESEARCH & DEVELOPMENT

Applicant Address

B-341 SENA BHAWAN, DHQ P.O., NEW DELHI-110 011, INDIA.

Inventors:

#	Inventor's Name	Inventor's Address
1	DR. PURNANAND	B-341 SENA BHAWAN, DHQ P.O., NEW DELHI-110011, INDIA.
2	DR. MALLADI VENKATA SATYA SURYANARAYANA	B-341 SENA BHAWAN, DHQ P.O., NEW DELHI-110 011, INDIA.
3	KRASHAN MURARI SONI	B-341 SENA BHAWAN, DHQ P.O., NEW DELHI-110 011, INDIA.
4	RAJENDRA KUMAR SHRIVASTAVA	B-341 SENA BHAWAN, DHQ P.O., NEW DELHI-110 011, INDIA.

PCT International Classification Number

A61K 31/01

PCT International Application Number

N/A

PCT International Filing date

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1			NA