Title of Invention	" 2-PYRIDINYLETHYLBENZAMIDE COMPOUNDS AND PROCESS FOR PREPARING THE SAME"
Abstract	2-pyridinylethylbenzamide compounds of general formula (1) in which R1, R2, R3, R4, R5, R6, R7, X, Y, n and p are as described in the specification and claims.

Full Text

New 2-pyridinylethylbenzamide compounds The present invention relates to novel N-[2-(2-pyridinyl)ethyl]benzamide derivatives, their process of preparation, their use as fungicides, particularly in the form of fungicidal compositions, and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions. The international patent application WO 01/11965 discloses a broad family of fungicidal compounds in which the 2-pyridyl group is substituted by at least one halogenoalkyl group. It is always of high-interest in agriculture to use novel pesticidal compounds in order to avoid or to fight the development of resistant strains to the active ingredients used by the farmer. It is also of high-interest to use novel compounds being more active than those already known, with the aim of decreasing the amounts of active material to be used by the farmer, whilst at the same time maintaining an effectiveness at least equivalent to the already known compounds. We have now found a new family of compounds which possess the above mentioned characteristics. Accordingly, the present invention relates to N-[2-(2-pyridinyl)ethyl]benzamide derivative of general formula (I): (Figure Removed) in which : -nis 1,2 or 3; - X is the same or different and is a hydrogen atom, a halogen atom, a nitro group, a cyano group, a hydroxy group, an amino group, a sulfanyl group, a pentafluoro-X6-suIfanyl group, a formyl group, a formyloxy group, a formylamino group, a carboxy group, a carbamoyl group, a N-hydroxycarbamoyl group, a carbamate group, a (hydroxyimino)-C1-C6-alkyl group, a C1-C6-alkyl, a C2-C8-alkenyl, a C2-C8-alkynyl, a C1-C8-alkylamino, a di-C1-C8-alkylamino, a C1-C8-alkoxy, a C1-C8halogenoalkoxy having 1 to 5 halogen atoms, a C1-C8-alkylsulfanyl, a C1-C8-halogenoalkylsulfanyl having 1 to 5 halogen atoms, a C2-C8-alkenyloxy, a C2-C8-halogenoalkenyloxy having 1 to 5 halogen atoms, a C3-C8-alkjoiyloxy, a C3-C8-halogenoalkynyloxy having 1 to 5 halogen atoms, a C3-C8-cycloalkyl, a C3-C8-halogenocycloalkyl having 1 to 5 halogen atoms, a C1-C8-alkylcarbonyl, a C1-C8-halogenoalkylcarbonyl having 1 to 5 halogen atoms, a C1-C8-alkylcarbamoyl, a di-C1-C8-alkylcarbamoyl, a (N-C1-C8-alkyl)oxycarbamoyl, a C1-C8-alkoxycarbamoyl, a (N-C1-C8-alkyl)-CrCs-alkoxycatbamoyl, a Ci-Cg-atkoxycarbonyt, a C1-C8-halogenoalkoxycarbonyl having 1 to 5 halogen atoms, a C1-C8-alkylcarbonyloxy, a C1-C8-halogenoalkylcarbonyloxy having 1 to 5 halogen atoms, a C1-C8-alkylcarbonylamino, a C1-C8-halogenoalkylcarbonylamino having 1 to 5 halogen atoms, a C1-C8-alkylaminocarbonyloxy, a di-C1-C8-alkyiaminocarbonyloxy, a C1-C8-alkyloxycarbonyloxy, a C1-C8-alkylsulphenyl, a C1-C8-halogenoalkylsulphenyl having 1 to 5 halogen atoms, a C1-C8-alkylsulphinyl, a C1-C8-halogenoalkylsulphiriyl having 1 to 5 halogen atoms, a C1-C8-alkylsulphonyl, a C1-C6-halogenoalkyl-sulphonyl having 1 to 5 halogen atoms, a (C1-C6-alkoxyiminoVC1-C6-alkyl, a (d-C6-alkenyloxyimino)-C1-C6-alkyl, a (C1-C6-alkynyloxyimino)-C1-C6-alkyl, a (benzyloxyimino)-C1-C6alkyl, a benzyloxy, a benzylsulfanyl, a benzylamino, a phenoxy, a phenylsulfanyl or a phenylamino; - R1 is a hydrogen atom, a halogen atom, a nitro group, a cyano group, a hydroxy group, an ammo group, a sulfanyl group, a pentafluoro-X6-sulfanyl group, a formyl group, a formyloxy group, a formylammo group, a carboxy group, a carbamoyl group, a N-hydroxycarbamoyl group, a carbamate group, a (hydroxyimino)-Ci-C6-alkyl group, a C1-C8alkyl, a C2-C8-alkenyl, a C2-C8-alkynyl, a C1-C8-alkyiamino, a di-C1-C8-alkylamino, a Ci-Cg-alkoxy, a C1-C8-halogenoalkoxy having 1 to 5 halogen atoms, a C1-C8alkylsulfanyl, a Ci-Cg-halogenoalkylsulfanyl having 1 to 5 halogen atoms, a C1-C8-alkenyloxy, a C1-C8-halogenoalkenyloxy having 1 to 5 halogen atoms, a C1-C8alkynyloxy, a C1-C8-halogenoalkynyloxy having 1 to 5 halogen atoms, a C1-C8cycloalkyl, a C1-C8-halogenocycloalkyl having 1 to 5 halog-n atoms, a C1-C8alkylcarbonyl, a C1-C8-halogenoalkylcarbonyl having 1 to 5 halogen atoms, a C1-C8alkylcarbamoyl, a di-C1-C8-alkylcarbamoyl, a N-C|-Cs-alkyloxycarbamoyl, a C1-C8alkoxycarbamoyl, a N-C1-C8alkyl-Ci-Cs-alkoxycarbamoyl, a C1-C8-alkoxycarbonyl, a C1-C8-halogenoalkoxycarbonyl having 1 to 5 halogen atoms, a C1-C8-alkylcarbonyloxy, a C1-C8halogenoalkylcarbonyloxy having 1 to 5 halogen atoms, a C1-C8-alkylcarbonylamino, a C1-C8-halogenoalkylcarbonylamino having 1 to 5 halogen atoms, a C1-C8-alkylaminocarbonyloxy, a di-C1-C8-alkylaminocarbonyloxy, a C1-C8- alkyloxycarbonyloxy, a C1-C8-alkylsulphenyl, a C1-C8-halogenoalkylsulphenyl having 1 to 5 halogen atoms, a C1-C8-alkylsulphinyl, a C1-C8-halogenoalkylsulphinyl having 1 to 5 halogen atoms, a C1-C8-alkylsulphonyl, a C1-C8-halogenoalkyl-sulphonyl having 1 to 5 halogen atoms, a (C1-C8-alkoxyimino)-C1-C6-alkyl, a (Ci-C6-alkenyloxyimino)-C1-C6-aIkyl, a (C1-C6alkynyloxyimino)-C1-C6alkyl, a (benzyloxyimino)-C1-C6alkyl, a benzyloxy, a benzylsulfanyl optionally substituted with 1 to 5 halogen atoms, a benzylamino, a phenoxy, a phenylsulfanyl optionally substituted with 1 to 5 halogen atoms or a phenylamino; with the proviso that X and R1 are not both a hydrogen atom; - R2 and R3 are the same or different and are a hydrogen atom, a halogen atom, a cyano group, a hydroxy group, a C1-C6-alkyl, a C1-C6-halogenoalkyl having 1 to 5 halogen atoms, a C1-C6-alkenyl, a C1-C6-alkoxy, a C1-C6-alkylsulfanyl, a C]- Ce-alkylsulfenyl, a C1-C6-alkylsulfinyl, a C1-C6alkoxycarbonyl, a C1-C6- alkylcarbonyloxy or a C1-C6-alkylcarbonylamino; or R2 and R3 may together form a 3-, 4-, 5- or 6-membered carbocycle; - R4 and R5 are the same or different and are a hydrogen atom, a halogen atom, a cyano group, a C1-C6-alkyl or a C1-C6-halogenoalkyl having 1 to 5 halogen atoms; or R4 and R5 may together form a 3-, 4-, 5- or 6-membered carbocycle; - R6 is a hydrogen atom, a cyano group, a formyl group, a hydroxy group, a C1-C6alkyl, a C1-C6-halogenoalkyl having 1 to 5 halogen atoms, a C1-C6-alkoxy, a C1-C6halogenoalkoxy having 1 to 5 halogen atoms, a C1-C6-cycIoalkyl, a C1-C6 halogenocycloalkyl having 1 to 5 halogen atoms, a C2-C6-alkenyl, aC1-C6-alkynyl, a C1-C6alkoxy-C1-C6-alkyl, a C1-C6cyanoalkyl, a C1-C6-aminoalkyl, a C1-C6 alkylamino-C1-C6-alkyl, a di-C1-C6alkylamino-C1-C6-alkyl, a C1-C6alkylcarbonyl, a C1-C6-halogenalkylcarbonyl having 1 to 5 halogen atoms, a C1-C6- alkyloxycarbonyl, a C1-C6benzyloxycarbonyl, a C1-C6-alkoxy-C1-C6-alkylcarbonyl, a C1-C6-alkylsulfonyl or a C1-C6-halogenoalkylsulfonyl having 1 to 5 halogen atoms; -p is 1,2, 3 or 4; - Y is the same or different and is a hydrogen atom, a halogen atom, a nitro group, a cyano group, a hydroxy group, an amino group, a sulfanyl group, a pentafluoro-X6-sulfanyl group, a formyl group, a formyloxy group, a formylamino group, a carboxy group, a C1-C8-alkyl, a C1-C6-halogenoalkyl having 1 to 5 halogen atoms, a C1-C6-alkenyl, a Ca-Cg-alkynyl, a C1-C6-alkylamino, a di-C1-C8-alkylamino, a C1-C6alkoxy, aC1-C6-halogenoalkoxy having 1 to 5 halogen atoms, aC1-C8- alkoxy-C1-C6-a!kenyl, a C1-C6-alkylsulfanyl, a C1-C6halogenoalkylsulfanyl having 1 to 5 halogen atoms, a C1-C8-alkoxycarbonyl, a C1-C8-halogenoalkoxycarbonyl having 1 to 5 halogen atoms, a C1-C8-alkylcarbonyloxy, a C1-C8-halogenoalkylcarbonyloxy having 1 to 5 halogen atoms, a C1-C8-alkylsulphenyl, a C1-C8-halogenoalkylsulphenyl having 1 to 5 halogen atoms, a C1-C8-alkylsulphinyl, a C1-C8halogenoalkylsulphinyl having 1 to 5 halogen atoms, a C1-C8-alkyl-sulphonyl, a C1-C8halogenoalkylsulphonyl having 1 to 5 halogen atoms or a C1-C8-alkylsulfonamide; and - R7 is a halogen atom, a nitro group, a cyano group, an amino group, a sulfanyl group, a pentafluoro-X.6-sulfanyl group, a formyl group, a formyloxy group, a formylamino group, a carboxy group, a C1-C8-alkyl, a C1-C8-halogenoalkyl having 1 to 5 halogen atoms, a C2-C8-alkenyl, a C2-C8-alkynyl, a C1-C8-alkylamino, a di-C1-C8-alkylamino, a CpCg-alkoxy, a Cj-Cg-halogenoalkoxy having 1 to 5 halogen atoms, a C1-C8-alkoxy-C2-C8-alkenyl, a C1-C8-alkylsulfanyl, a C1-C8-halogenoalkylsulfanyl having 1 to 5 halogen atoms, a C1-C8alkoxycarbonyl, a C1-C8-halogenoalkoxycarbonyl having 1 to 5 halogen atoms, a C1-C8-alkylcarbonyloxy, a C1-C8-halogenoalkylcarbonyloxy having 1 to 5 halogen atoms, a C1-C8-alkylsulphenyl, a C1-C8-halogenoalkylsulphenyl having 1 to 5 halogen atoms, a Cp Cs-alkylsulphinyl, a C1-C8--halogenoalkylsulphinyl having 1 to 5 halogen atoms, a C1-C8--alkylsulphonyl, a C1-C8--halogenoalkylsulphonyl having 1 to 5 halogen atoms or a Ci-Cg-alkylsulfonamide; as well as its salts, N-oxydes, metallic and metalloidic complexes. In the context of the present invention : - halogen means fluorine, bromine, chlorine or iodine. -carboxy means -C(=O)OH; carbonyl means -C(=O)-; carbamoyl means -C(=0)NH2; N-hydroxycarbamoyl means -C(=0)NHOH ; - an alkyl group, an alkenyl group, and an alkynyl group as well as moieties containing these terms, can be linear or branched. In the context of the present invention, it has also to be understood that in the case of di-substituted amino and of di-substituted carbamoyl radicals, the two substituents may form together with the nitrogen atom bearing them a saturated heterocyclic ring containing 3 to 7 atoms. Any of the compound of the present invention can exist in one or more optical or chiral isomer forms depending on the number of asymmetric centres in the compound. The invention thus relates equally to all the optical isomers and to their racemic or scalemic mixtures (the term "scalemic" denotes a mixture of enantiomers in different proportions), and to the mixtures of all the possible stereoisomers, in all proportions. The diastereoisomers and/or the optical isomers can be separated according to the methods which are known per se by the man ordinary skilled in the art. Any of the compound of the present invention can also exist in one or more geometric isomer forms depending on the number of double bonds in the compound. The invention thus relates equally to all geometric isomers and to all possible mixtures, in all proportions. The geometric isomers can be separated according to general methods, which are known per se by the man ordinary skilled in the art. Any of the compound of general formula (I) wherein R1 represents a hydroxy or sulfanyl group, and/or X represents a hydroxy, sulfanyl or amino group, may be found in its tautomeric form resulting of the shift of the proton of said hydroxy, sulfanyl or amino group. Such tautomeric forms of such compounds are also part of the present invention. More generally speaking, all tautomeric forms of compounds of general formula (I) wherein Rj represents a hydroxy or sulfanyl group, and/or X represents a hydroxy, sulfanyl or amino group, as well as the tautomeric forms of the compounds which can optionally be used as intermediates in the preparation processes, and which will be defined in the description'of these processes, are also part of the present invention. According to the present invention, the 2-pyridyl is substituted in 6-position by R1 and may be substituted in any other position by (X)n, in which X and n are as defined above. Preferably, the present invention relates to N-[2-(2-pyridinyl)ethyl]benzamide derivative of general formula (I) in which the different characteristics may be chosen alone or in combination as being : - as regards R1, R1 is a hydrogen atom or a halogen atom; - as regards n, n is 1 or 2; - as regards X, X is a halogen atom or a C1-C6-alkyl; - as regards the positions in which the 2-pyridyl moiety is substituted by X, the 2- pyridyl moiety is substituted by X in 3- and/or in 5-position. According to the present invention, the phenyl is substituted in ortho position by R7 and may be substituted in any other position by (Y)p, in which Y and p are as defined above. Preferably, the present invention relates to N-[2-(2-pyridinyl)ethyl]benzamide derivative of general formula (I) in which the different characteristics may be chosen alone or in combination as being : - as regards R7, R7 is a halogen atom, a C1-C6alkyl or a C1-C6-halogenoalkyl having 1 to 5 halogen atoms; - as regards p, p is 1 or 2. More preferably, p is 1. - as regards Y, Y is a hydrogen atom, a halogen atom or a C1-C6-alkyl. More preferably Y is a hydrogen atom; - as regards the positions in which the phenyl moiety is substituted by Y, the phenyl moiety is substituted by Y preferentially first in para position. The present invention also relates to a process for the preparation of the compound of general formula (I). Thus, according to a further aspect of the present invention there is provided a process (A) for the preparation of compound of general formula (la) pg x (Figure Removed) wherein : - R1, R2, R7, X, Y, n and p are as defined above; -R3 is a C1-C6alkyl; which comprises - a first step according to reaction scheme A-l : Scheme A-l (Figure Removed) in which : - R1, R2, X and n are as defined above; - R8 is a C1-C6 alkyl, a C1-C6 haloalkyl, a benzyl, 4- methoxybenzyl or pentafluorophenyl; - U is a leaving group chosen as being a halogen, a C1-C6 alkylsulfonate or a C1-C6haloalkylsulfonate; comprising the arylation of a cyanoacetate derivative of general formula (III) by a pyridine derivative of general formula (II), to provide a 2-(pyridyl)cyanoacetate derivative of general formula (IV), in the presence of a base, at a temperature of from 0°C to 200°C; - a second step according to reaction scheme A-2 : Scheme A-2 (Figure Removed) in which : - R1, R2, X, n are as defined above; - R3 is a hydrogen atom; - R8 is a C1-C6 alkyl, a C1-C6 haloalkyl, a benzyl, 4- methoxybenzyl or pentafluorophenyl; comprising a basic hydrolysis, an acidic hydrolysis or a displacement by an halide of a compound of general formula (IV) in the same or a different pot to provide, upon heating at a temperature of from 40°C to reflux, a 2-pyridylacetonitrile derivative of general formula (Va); - a third step according to reaction scheme A-3 : Scheme A-3 i(Figure Removed) n which : - R1, R2, X, n are as defined above; -R3 is aC1-C6alkyl; - W is a halogen atom, a C1-C6 alkylsulfonate, a haloalkyl sulfonate or a 4-methyI-phenylsulfonate, comprising the alkylation of a compound of general formula (Va) by a reagent of general formula (XVII) to provide a compound of general formula (Vb); - a fourth step according to reaction scheme A-4 : (Figure Removed) which : - - R1, R2, X, n are as defined above; - R3 is a hydrogen atom or a C1-C6alkyl; I - L is a leaving group chosen as being a -OR group or a - OCOR8 group, R8 being a C1-C6alkyl, a C1-C6 haloalkyl, a benzyl, 4-methoxybenzyl or pentafluorophenyl; - PG represents a protecting group which may be a -COOR8 group or -COR8 groupr, Rs being a C1-C6 alkyl, a C1-C6 haloalkyl, a benzyl, 4- methoxybenzyl or pentafluorophenyl; comprising the reduction, by hydrogenation or by an hydride donor, of a compound of general formula (Va) or (Vb), in the presence of a catalyst and in the presence of a compound of general formula (VI) to produce a compound of general formula (VII), at a temperature of from 0°C to 150°C and under a pressure of from 1 bar and 100 bar; - a fifth step according to reaction scheme A-5 : Scheme A-5 (Figure Removed) in which : - R1, R2, X, n are as defined above; -R3 is a C1-C6alkyl; - PG represents a protecting group which may be a -COOR group or -COR8 group, Rs being a C1-C6 alkyl, a C1-C6 haloalkyl, a benzyl, 4-methoxybenzyl or pentafluorophenyl; comprising a deprotection reaction, in an acidic or in a basic medium, of a compound of general formula (VII) to provide an amine derivative of general formula (Villa) or one of its salt; - a sixth step according to reaction scheme A-6 : Scheme A-6 (Figure Removed) in which : - R1, R2, R7, X, Y, n and p are as defined above; - R3 is a C1-C6 alkyl; - L is a leaving group chosen as being a halogen atom, a hydroxyl group, an OR8 group, an OCOR8, R8 being a C1-C6 alkyl, a C1-C6haloalkyl, a benzyl, 4-methoxybenzyl or pentafluorophenyl; or a group of formula o (Figure Removed) comprising a coupling reaction of an amine derivative of general formula (Villa) or one of its salt, with a carboxylic acid derivative of formula (IX) to provide a compound of general formula (la). The first step (step A-l) of the process A according to the present invention is conducted in the presence of a base. Preferably, the base will be chosen as being an inorganic or an organic base. Suitable examples of such bases may for example be alkaline earth metal or alkali metal hydrides, hydroxides, amides, alcoholates, carbonates or hydrogen carbonates, acetates or tertiary amines. The first step (step A-l) of the process A according to the present invention is conducted at a temperature of from 0°C to 200°C. Preferably, first step (step A-l) is conducted at a temperature of from 0°C to 120°C, more preferably at a temperature offromO°Cto80°C. The first step (step A-l) of the process A according to the present invention may be conducted in the presence of a solvent. Preferably, the solvent is chosen as being water, an organic solvent or a mixture of both. Suitable organic solvents may for example be aliphatic, alicyclic or aromatic solvent. The first step (step A-l) of the process A according to the present invention may also be conducted in the presence of a catalyst. Preferably, the catalyst is chosen as being palladium salts or complexes. More preferably, the catalyst is chosen as being a palladium complex. Suitable palladium complex catalyst may for example be generated directly in the reaction mixture by separately adding to the reaction mixture a palladium salt and a complex ligand. Suitable ligands may for example be bulky phosphines or arsines ligands, such as (R).(.)_i_[(S)-2- (dicyclohexylphosphino)ferrocenyl]ethyldicyclohexylphosphine and its corresponding enantiomer, or a mixture of both; (R)-(-)-l[(S)-2- (dicyclohexylphosphino)ferrocenyl] hyldiphenylphosphine and its corresponding enantiomer, or a mixture of both; (R)-(-)-l[(S)-2~ (diphenylphosphino)ferrocenyl]ethyldi-t-butylphosphine and its corresponding enantiomer, or , a mixture of both; or (R)-(-)-l[(S)-2-(diphenylphosphino)ferrocenyl]ethyldicyclohexylphospliine and its corresponding enantiomer, or a mixture of both. The fourth step (step A-4) of the process A according to the present invention is conducted in the presence of a hydride donor. Preferably, the hydride donor 'is chosen as being metal or metallloid hydrides such as LiAlH4, NaBH4, KBH4, B2H6- The fourth step (step A-4) of the process A according to the present invention is conducted in the presence of a catalyst. Preferably, the catalyst is chosen as being Co(II)-Chloride, Ni(II)-chloride, ammonia or one of its salt, Palladium on charcoal, Raney Nickel, Raney Cobalt or Platinum. The fourth step (step A-4) of the process A according to the present invention is conducted at a temperature of from 0°C to 150°C. Preferably the temperature is of from 10°C to 120°C. More prefereably, the temperature is of from 10°C to SO°C. The fourth step (step A-4) of the process A according to the present invention is conducted under a pressure of from 1 bar to 100 bar. Preferably the pressure is of from 1 bar to 50 bar. The fourth step (step A-4) of the process A according to the present invention may be conducted in the presence of an organic solvent, of water or of a mixture thereof. Preferably, the solvent is chosen as being ether, alcohol, carboxylic acid, or a mixture thereof with water or pure water. The present invention also relates to another process for the preparation of the compound of general formula (I). Thus, according to a further aspect of the present invention there is provided a second process B for the preparation compound of general formula (la) (X)1)N (Figure Removed) wherein : - R1, R2, R7, X, Y, n and p are as defined above; -R3 is a C1-C6alkyl; 'which comprises - a first step according to reaction scheme B-l : Scheme B-l (Figure Removed) in which : - R1, R2, X and n are as defined above; - V is a C1-C6 alkyl, a C1-C6 haloalkyl, a benzyl, 4- methoxybenzyl or pentafluorophenyl; - U is a leaving group chosen as being a halogen atom, a C1-C6 alkylsulfonate or a C1-C6haloalkylsulfonate; comprising the arylation of a cyanoacetate derivative of general formula (III) by a pyridine derivative of general formula (II) to provide a 2-pyridylcyanoacetate derivative of general formula (IV); - a second step according to reaction scheme B-2 : SchenmB-2 (Figure Removed) in which : - R1, R2, X and n are as defined above; - R8 is a C1-C6 alkyl, a C1-C6 haloalkyl, a benzyl, 4-methoxybenzyl or pentafluorophenyl; comprising a basic hydrolysis, an acidic hydrolysis or a displacement by an halide of a compound of general formula (IV) in the same or a different pot to provide, upon heating at a temperature of from 40°C to reflux, a 2-pyridylacetonitrile derivative of general formula (Va); a third step according to reaction schemeB-3 Scheme B-3 (Figure Removed) in which : - R1, R2, X, n are as defined above; -R3 is a C1-C6 alkyl; - W is a halogen atom, a C1-C6 alkylsulfonate, a haloalkylsulfonate or a 4-methyl-phenylsulfonate, comprising the alkylation of a compound of general formula (Va) by a reagent of general formula (XVII) to provide a compound of general formula (Vb); - a fourth step according to reaction scheme B-4 : Scheme B- - R!, R2, R7, X, Y, n and p are as defined above; - 3 is a C1-C6 alkyl; - L3 is a leaving group chosen as being -OCOR8, Rs being a C1-C6alkyl, a Cg haloalkyl, a benzyl, 4-methoxybenzyl or pentafluorophenyl; -OCHO, -SCSN(Me)2 or a group of formula (Figure Removed) comprising the reduction by hydrogenation or by an hydride of a compound of general formula (Va) or a compound of general formula (Vb) in the presence of a catalyst and in the presence of a compound of general formula (IX) to produce a compound of general formula (la), at a temperature of from 0°C to 150°C and under a pressure of from 1 bar and 100 bar. Compound of general formula (la) according to the present invention may be prepared according to the process B. The preferred conditions under which step B-l of the process B is conducted are the same than the preferred conditions under which step A-l of the above mentioned process A is conducted. The preferred conditions under which step B-2 of the process B is conducted are the same than the preferred conditions under which step A-2 of the above mentioned process A is conducted. The preferred conditions under which step B-3 of the process B is conducted are the same than the preferred conditions under which step A-3 of the above mentioned process A is conducted. The preferred conditions under which step B-4 of the process B is conducted are the same than the preferred conditions under which step A-4 of the above mentioned process A is conducted. The present invention also relates to another process for the preparation of the compound of general formula (I). Thus, according to a further aspect of the present invention there is provided a third process C for the preparation compound of general formula (la) (Figure Removed) wherein R1, R2, R3, R7, X, Y, n and p are as defined above; which comprises - a first step according to reaction scheme C-l : Scheme C-l (Figure Removed) in which : - R1, R2, R3, X and n are as defined above; - U is a leaving group chosen as being a halogen atom, a C1-C6 alkylsulfonate or a C1-C6 haloalkylsulfonate; comprising the arylation of a compound of general formula (IIIb) by a pyridine derivative of general formula (II) to provide a 2-pyridylacetonitriJe derivative of genera] formula (Vb), in the presence of a base and at a at temperature of from - 100°Cto200°C; - a second step according to reaction scheme C-2 : Scheme C-2 (Figure Removed) in which : - R1, R2, R3, X and n are as defined above; - Ll is a leaving group chosen as being a -OR8 group or a - OCOR8 group, R8 being a C1-C6 alkyl, a C1-C6 haloalkyl, a benzyl, 4-methoxybenzyl or pentafluorophenyl; A - PG represents a protecting group which may be a -COOR group or -COR8 group, R8 being a C1-C6 alkyl, a C1-C6 haloalkyl, a benzyl, 4- methoxybenzyl or pentafluorophenyl; comprising the reduction, by hydrogenation or by an hydride donor, of a compound of general formula (Va) or (Vb), in the presence of a compound of general formula (VI) to produce a compound of general formula (VII); - a third step according to reaction scheme C-3 : Scheme C-3 (Figure Removed) in which : - R , R , R , X and n are as defined above; - PG represents a protecting group which may be a -COOR group or -COR8 group, R8 being a C1-C6 alkyl, a C1-C6 haloalkyl, a benzyl, 4-methoxybenzyl or pentafluorophenyl; comprising a deprotection reaction, in an acidic or in a basic medium, of a compound of general formula (VII) to provide an amine derivative of general formula (Villa) or one of its salt; - a fourth step according to reaction scheme C-4 Scheme C-4 (Figure Removed) in which : - R1, R2, R3, R7, X, Y, n and p are as defined above; - L4 is a leaving group chosen as being a halogen atom, a hydroxyl group, -OCHO, -SCSN(Me)2, an ORS group, an OCOR8, R8 being a C1-C6 alkyl, a C1-C6 haloalkyl, a benzyl, 4-methoxybenzyl or pentafluorophenyl; or a group of formula (Figure Removed) comprising a coupling reaction of an amine derivative of general formula (Villa) or one of its salt, with a carboxylic acid derivative of formula (IX) to provide a compound of general formula (la). The first step (step C-l) of the process C according to the present invention is conducted at a temperature of from -100°C to 200°C. Preferably, first step (step A-l) is conducted at a temperature of from -80°C to 120°C, more preferably at a temperature of from -80°C to 80°C. The first step (step C-l) of the process C according to the present invention is conducted in the presence of a base. Preferably, the base will be chosen as being an inorganic or an organic base. Suitable examples of such bases may for example be alkaline earth metal or alkali metal hydrides, hydroxides, amides, alcoholates, carbonates or hydrogen carbonates, acetates or tertiary amines. The first step (step C-l) of the process C according to the present invention may be conducted in the presence of a solvent. Preferably, the solvent is chosen as being water, an organic solvent or a mixture of both. Suitable organic solvents may for example be aliphatic, alicyclic or aromatic solvent. The first step (step C-l) of the process C according to the present invention may also be conducted in the presence of a catalyst. Preferably, the catalyst is chosen as being palladium salts or complexes. More preferably, the catalyst is chosen as being a palladium complex. Suitable palladium complex catalyst may for example be generated directly in the reaction mixture by separately adding to the reaction mixture a palladium salt and a complex ligand. Suitable ligands may for example be bulky phosphines or arsines ligands, such as (R)-(-)-l-[(S)-2- (dicyclohexylphosphino)ferrocenyl]ethyldicyclohexylphosphine and its corresponding enantiomer, or a mixture of both; (R)-(-)-l[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyldiphenylphosphine and its corresponding enantiomer, or a mixture of both; (R)-(-)-l[(S)-2-(diphenylphosphino)ferrocenyl]ethyldi-t-butylphosphine and its corresponding enantiomer, or a mixture of both; or (R)-(-)-l[(S)-2-(diphenylphosphino)ferrocenyl]ethyldicyclohexylphosphine and its corresponding enantiomer, or a mixture of both. The preferred conditions under which step C-2 of the process C is conducted are the same than the preferred conditions under which step A-4 of the above mentioned process A is conducted. The preferred conditions under which step C-3 of the process C is conducted are the same than the preferred conditions under which step A-5 of the above mentioned process A is conducted. The preferred conditions under which step C-4 of the process C is conducted are the same than the preferred conditions under which step A-6 of the above mentioned process A is conducted. The present invention also relates to another process for the preparation of the compound of general formula (I). Thus, according to a further aspect of the present invention there is provided a fourth process D for the preparation of compound of general formula (la) (Figure Removed) wherein : - R1, R2, R7, X, Y, n and p are as defined above; -R3 is aC1-C6 alkyl; which comprises - a first step according to reaction scheme D-l : Scheme D-l (Figure Removed) - R1, R2, R3, X and n are as defined above; - U is a leaving group chosen as being a halogen atom, a C1-C6 alkylsulfonate or a Ci-Cehaloalkylsulfonate; comprising the arylation of a compound of general formula (Illb) by a pyridine derivative of general formula (II) to provide a 2-pyridylacetonitrile derivative of general formula (Vb), in the presence of a base and at a at temperature of from -100°Cto200°C; - a second step according to reaction scheme D-2 : Scheme D-2 (Figure Removed) in which : - R1, R2, R7, X, Y, n and p are as defined above; -R3 is a C1-C6 alkyl; 3 - L is a leaving group chosen as being -OCOR , R being a C1-C6 alkyl, a C1-C6 haloalkyl, a benzyl, 4-methoxybenzyl or pentafluorophenyl; -OCHO, -SCSN(Me)2 or a group of formula ° (Figure Removed) comprising the reduction by hydrogenation or by an hydride donor a compound of general formula (Va) or a compound of general formula (Vb) in the presence of a compound of general formula (IX) to provide a compound of general formula (la). Compound of general formula (la) according to the present invention may be prepared according to the process D, The preferred conditions under which step D-l of the process D is conducted are the same than the preferred conditions under which step C-l of the above mentioned process C is conducted. The preferred conditions under which step D-2 of the process D is conducted are the same than the preferred conditions under which step A-4 of the above mentioned process A is conducted. The present invention also relates to a process for the preparation of the compound of general formula (I). Thus, according to a further aspect of the present invention there is provided a fifth process (E) for the preparation of compound of general formula (la) (X)nv (Figure Removed) wherein : - R1 , R2, R3, R7, X, Y, n and p are as defined above; - R4 is a hydrogen atom, a C1-C6 alkyl or a C1-C6 haloalkyl; - R5 is a C1-C6 alkyl or a C1-C6 haloalkyl; - L4 is a leaving group chosen as being a halogen atom, a hydroxyl group, -OCHO, -SCSN(Me)2, an OR8 group, an OCOR8, R8 being a C1-C6 alkyl, aC1-C6 haloalkyl, a benzyl, 4- methoxybenzyl or pentafluorophenyl; or a group of formula (Figure Removed) which comprises - a first step according to reaction scheme E-l : Scheme E-l (Figure Removed) in which : - R1, R2, R3, X and n are as defined above: - R4 is a hydrogen atom, a C1-C6 alkyl or a Ci-C6haloalkyl; - U is a leaving group chosen as being a halogen atom, a C1-C6 alkylsulfonate or a C1-C6 haloalkylsulfonate; comprising the arylation of a compound of general formula (X) by a pyridine derivative of general formula (II) to provide a compound of general formula (XI); - a second step according to reaction scheme E-2 : Scheme E-2 (Figure Removed) in which : - R1, R2, RJ, X and n are as defined above; , - R4 is a hydrogen atom, a C1-C6 alkyl or a C1-C6 haloalkyl; comprising the conversion of a compound of general formula (XI) into a compound of general formula (XIII) by addition of a compound of general formula R5-M., in which R5 is a C1-C6 alkyl or a C1-C6 haloalkyl and M is a metal specie; - a third step according to reaction scheme E-3 : Scheme E-3 (Figure Removed) in which : - R1, R2, R3, X and n are as defined above; - R4 is a hydrogen atom, a C1-C6 alkyl or a C1-C6 haloalkyl; - R5 is a C1-C6 alkyl or a C1-C6 haloalkyl; - W is a leaving group chosen as being a halogen atom, a C1-C6 alkylsulfonate, a CpCehaloalkylsulfonate or a 4-methyl-phenylsulfonate; comprising the activation of a compound of general formula (XIII) by converting it intoa compound of general formula (XIV); - a fourth step according to reaction scheme E-4 : Scheme E-4 (Figure Removed) in which : - R1, R2, R3, X and n are as defined above; - R4 is a hydrogen atom, a C1-C6 alkyl or a C1-C6 haloalkyl; - R5 is a C1-C6 alkyl or a C1-C6 haloalkyl; - W is a leaving group chosen as being a halogen atom, a C1-C6 alkylsulfonate, a C1-C6 haloalkylsulfonate or a 4-methyl-phenylsulfonate; comprising the substitution of a compound of general formula (XIV) by a phtalimide derivative or one of its salt to provide a compound of general formula (XVa); - a fifth step according to reaction scheme E-5 : Scheme E-5 - (Figure Removed) in which : - R1, R2, R3, X and n are as defined above; - R4 is a hydrogen atom, a C1-C6 alkyl or a C1-C6 haloalkyl; - R5 is a C1-C6 alkyl or a C1-C6 haloalkyl; comprising the de-protection of a compound of general formula (XVa) by reacting it with hydrazine hydrate or a hydrazine salt to provide an amine derivative of general formula (VHIc) or one of its salt; - a sixth step according to reaction scheme E-6 : Scheme E-6 (Figure Removed) in which : - R1, R2, R3, R7, X, Y, n and p are as defined above; - R4 is a hydrogen atom, a C1-C6 alkyl or a C1-C6 haloalkyl; - R5 is a C1-C6 alkyl or a C1-C6 haloalkyl; - L4 is a leaving group chosen as being a halogen atom, a hydroxyl group, -OCHO, -SCSN(Me)2, an OR8 group, an OCOR8, R8 being a C1-C6 alkyi, a C1-C6 haloalkyl, a benzyl, 4- methoxybenzyl or pentafluorophenyl; or a group of formula (Figure Removed) - comprising a coupling reaction of an amine derivative of general formula (VHIb) or one of its salt, with a carboxylic acid derivative of formula (IX) to provide a compound of general formula (la). Compound of general formula (I) according to the present invention may be prepared according to the process E. The preferred conditions under which step E-6 of the process E is conducted are the same than the preferred conditions under which step A-6 of the above mentioned process A is conducted. The present invention also relates to another process for the preparation of the compound of general formula (I). Thus, according to a further aspect of the present invention there is provided a sixth process F for the preparation of compound of general formula (la) (Figure Removed) wherein : - R1, R7, X, Y, n and p are as defined above; - R', R4 and R5 are independently from each other chosen as being a hydrogen atom, a C1-C6 alkyl or a C1-C6 ghaloalkyl; which comprises - a first step according to reaction scheme F-l : Scheme F-l (Figure Removed) in which : - R1, X and n are as defined above; - U is a leaving group chosen as being a halogen atom a C1-C6 alkylsulfonate or a C1-C6 haloalkylsulfonate; - R2, R4 and R5 are independently from each other chosen as being a hydrogen atom, a C1-C6 alkyl or a C1-C6 haloalkyl; - M is a metal or a metalloid specie; comprising a coupling reaction of a pyridine derivative of general formula (II) with a vinylic specie of general formula (XVI), at a temperature of from 0°C to 200°C, to provide a compound of general formula (XVII); - a second step according to reaction scheme F-2 : Scheme F-2 (Figure Removed) in which : - R1, X and n are as defined above; - R2, R4 and R5 are independently from each other chosen 'as being a hydrogen atom/a C1-C6 alkyl or aC1-C6 haloalkyl; comprising the addition of a phtalimide or one of its salt on a compound of general formula (XVII) to provide a compound of general formula (XVb); - a third step according to reaction scheme F-3 : Scheme F-3 (Figure Removed) In which R1, X and n are as defined above; - R2, R4 and R5 are independently from each other chosen as being a hydrogen atom, a C1-C6 alkyl or a C1-C6 haloalkyl; comprising the de-protection of a compound of general formula (XVb) with hydrazine hydrate or an hydrazine salt, to provide an amine derivative of general formula (Vllld) or one of its salts; - a fourth step according to reaction scheme F-4 : Scheme F-4 (Figure Removed) R1, R7, X, Y, n and p are as defined above; ' - R2, R4 and R5 are independently from each other chosen as being a hydrogen atom, a C1-C6 alkyl or a C1-C6 haloalkyl; - L4 is a leaving group chosen as being a halogen atom, a hydroxyl group, -OCHO, -SCSN(Me)2, an OR8 group, an OCOR8, R8 being a C1-C6 alkyl, a C1-C6 haloalkyl, a benzyl, 4-methoxybenzyl or pentafluorophenyl; or a group of formula (Figure Removed) comprising a coupling reaction of an amine derivative of general formula (VHIb) or one of its salt, with a carboxylic acid derivative of formula (IX) to provide a compound of general formula (la). The first step (step F-l) of the process F according to the present invention is conducted in the presence of a vinylic specie of general formula (XVI) in which M can be a metal or a metalloid specie. Preferably M is a tin derivative or a boron derivative. More preferably M is a tri-ttbutyltin group. The first step (step F-l) of the process F according to the present invention is conducted at a temperature of from 0°C to 200°C. Preferably, step G-l is conducted at a temperature of from 60°C to 160°C, more preferably at temperature of from SO°Ctol40°C. The first step (step F-l) of the process F according to the present invention may be conducted in the presence of a solvent. Preferably, the solvent is chosen as being water, an organic solvent or a mixture of both. Suitable organic solvents may for example be aliphatic, alicyclic or aromatic solvent. The first step (step F-l) of the process F according to the present invention may also be conducted in the presence of a catalyst. Preferably, the catalyst is chosen as being palladium salts or complexes. More preferably, the catalyst is chosen as being a palladium complex. Suitable palladium complex catalyst may for example be generated directly in the reaction mixture by separately adding to the reaction mixture a palladium salt and a complex ligand. Suitable ligands may for example be bulky phosphines or arsines ligands, such as (R)-(-)-i-[(S)-2- (dicyclohexylphosphino)ferrocenyl]ethyldicyciohexylphosphine and its corresponding enantiomer, or a mixture of both; (R)-(-)-l[(S)-2- (dicyclohexylphosphino)ferrocenyl]ethyldiphenylphosphine and its corresponding enantiomer, or a mixture of both; (R)-(-)- l[(S)-2- (diphenylphosphino)ferrocenyl]ethyldi-t-butylphosphine and its corresponding enantiomer, or ' a mixture of both; or (R)-(-)-l[(S)-2-(diphenylphosphino)ferrocenyl]ethyldicyclohexylphosphine and its corresponding enantiomer, or a mixture of both. The first step (step F-l) of the process F according to the present invention may also be conducted in the presence of a base. Preferably, the base is chosen as being an inorganic or an organic base. Suitable examples of such bases may for example be alkaline eatth metal or alkali metal hydrides, hydroxides, amides, alco-holates, carbonates or hydrogen carbonates, acetates or tertiary amines. The preferred conditions under which step F-3 of the process F is conducted are the same than the preferred conditions under which step E-5 of the above mentioned process E is conducted. The preferred conditions under which step F-4 of the process F is conducted are the same than the preferred conditions under which step A-6 of the above mentioned process A is conducted. Any of the above described processes A to F may optionally comprise a further step according to reaction scheme G : Scheme G (Figure Removed) in which : - R1 , R2, R3, R4, R5, R6, R7 , X, Y, n and p are as defined above; - L5 is a leaving group chosen as being a halogen atom, a 4-methy! phenylsulfonyloxy, a methylsulfonyloxy; comprising the reaction of a compound of general formula (la) with a compound of general formula (XVI) to provide a compound of general formula (Ib). The present invention also relates to another process for the preparation of the compound of general formula (I). Thus, according to a further aspect of the present invention there is provided a seventh process H for the preparation of compound of general formula (I) as defined above, which comprises - a first step according to reaction scheme H-l : Scheme H-l (Figure Removed) - R1, R2, R3, X and n are as defined above; - R4 is a hydrogen atom, a C1-C6 alkyl or a C1-C6 haloalkyl; - U is a leaving group chosen as being a halogen atom, a C1-C6 alkylsulfonate or a C1-C6 haloalkylsulfonate; comprising the arylation of a compound of general formula (X) by a pyridine derivative of general formula (II) to provide a compound of general formula (XI), in the presence of a base, at a temperature of from 0°C to 200°C; - a second step according to reaction scheme H-2 : Scheme H-2 (Figure Removed) in which : - R, R, R, X and n are as defined above; - R4 is a hydrogen atom, a C1-C6 alkyl or a C1-C6 haloalkyl; - R6 is a hydrogen atom, a C1-C6 alkyl, a C1-C6 haloalkyl, a C1 C6 alkoxy or a C3-C7 cycloalkyl; comprising the reaction of a compound of general formula (XI) with an amine of formula R6-NH2 to provide an imine derivative of general formula (XII); - a third step according to scheme H-3 : (Figure Removed) in which : - R1, R2, R3, X and n are as defined above; • - R4 is a hydrogen atom, a C1-C6 alkyl or a C1-C6 haloalkyl; - R6 is a hydrogen atom, a Ci-Cs alkyl, a C1-C6 haloalkyl, a C1 C6 alkoxy or a C3-C7 cycloalkyl; comprising the reduction of an inline derivative of general formula (XII) by hydrogenation or by an hydride donor, in the same or a different pot to provide an amine derivative of general formula (Vlllb) or one of its salt; - a fourth step according to reaction scheme H-4 : Scheme H-4 (Figure Removed) in which : - R1, R2, R3, R7, X, Y, n and p are as defined above; -R4 is a hydrogen atom, a C1-C6 alkyl or a C1-C6 haloalkyl; - R6 is a hydrogen atom, a C1-C6 alkyl, a C1-C6 haloalkyl, a C1 C6 alkoxy or a C3-C7 cycloalkyl; - L4 is a leaving group chosen as being a halogen atom, a hydroxyl group, -OCHO, -SCSN(Me)2, an OR8 group, an OCOR8, R8 being a C1-C6 alkyl, aC1-C6 haloalkyl, a benzyl, 4-methoxybenzyl or pentafluorophenyl; or a group of formula. (Figure Removed) comprising a coupling reaction of an amine derivative of general formula (Vlllb) or one of its salt, with a carboxylic acid derivative of formula (IX) to provide a compound of general formula (I). Compound of general formula (I) according to the present invention may be prepared according to the process H. The preferred conditions under which step H-l of the process H is conducted are the same than the preferred conditions under which step A-l of the above mentioned process A is conducted. The third step (step H-3) of the process H according to the present invention is conducted in the presence of a hydride donor. Preferably, the hydride donor is chosen as being metal or metallloid hydrides such as LiAIHa, NaBHa, KBHi, B2H6- The compound according to the present invention can be prepared according to the general processes of preparation described above. It will nevertheless be understood that, on the basis of his general knowledge and of available publications, the skilled worker will be able to adapt this method according to the specifics of each of the compounds, whidi it is desired to synthesise. The present invention also relates to a fungicidal composition comprising an effective amount of an active material of general formula (I). Thus, according to the present invention, there is provided a fungicidal composition comprising, as an active ingredient, an effective amount of a compound of general formula (I) as defined above and an agriculturally acceptable support, carrier or filler. In the present specification, the term "support" denotes a natural or synthetic, organic or inorganic material with which the active material is combined to make it easier to apply, notably to the parts of the plant. This support is thus generally inert and should be agriculturally acceptable. The support may be a solid or a liquid. Examples of suitable supports include clays, natural or synthetic silicates, silica, resins, waxes, solid fertilisers, water, alcohols, in particular butanol, organic solvents, mineral and plant oils and derivatives thereof. Mixtures of such supports may also be used. The composition may also comprise additional components. In particular, the composition may further comprise a surfactant. The surfactant can be an emulsifier, a dispersing agent or a wetting agent of ionic or non-ionic type or a mixture of such surfactants. Mention may be made, for example, of polyacrylic acid salts, lignosulphonic acid salts, phenolsulphonic or naphthalenesulphonic acid salts, polycondensates of ethylene oxide with fatty alcohols or with fatty acids or with fatty amines, substituted phenols (in particular alkylphenols or arylphenols), salts of sulphosuccinic acid esters, taurine derivatives (in particular alkyl taurates), phosphoric esters of polyoxyethylated alcohols or phenols, fatty acid esters of polyols, and derivatives of the above compounds containing sulphate, sulphonate and phosphate functions. The presence of at least one surfactant is generally essential when the active material and/or the inert support are water-insoluble and when the vector agent for the application is water. Preferably, surfactant content may be comprised between 5% and 40% by weight of the composition. Optionally, additional components may also be included, e.g. protective colloids, adhesives, thickeners, thixotropic agents, penetration agents, stabilisers, sequestering agents. More generally, the active materials can be combined with any solid or liquid additive, which complies with the usual formulation techniques. In general, the composition according to the invention may contain from 0.05 to 99% (by weight) of active material, preferably 10 to 70% by weight. Compositions according to the present invention can be used in various forms such as aerosol dispenser, capsule suspension, cold fogging concentrate, dustable powder, emulsifiable concentrate, emulsion oil in water, emulsion water in oil, encapsulated granule, fine granule, flowable concentrate for seed treatment, gas (under pressure),gas generating product, granule, hot fogging concentrate, macrogranule, microgranule, oil dispersible powder, oil miscible flowable concentrate, oil miscible liquid, paste, plant rodlet, powder for dry seed treatment, seed coated with a pesticide, soluble concentrate, soluble powder, solution for seed treatment, suspension concentrate (flowable concentrate), ultra low volume (ulv) liquid, ultra low volume (ulv) suspension, water dispersible granules or tablets, water dispersible powder for slurry treatment, water soluble granules or tablets, water soluble powder for seed treatment and wettable powder. These compositions include not only compositions which are ready to be applied to the plant or seed to be treated by means of a suitable device, such as a spraying or dusting device, but also concentrated commercial compositions which must be diluted before application to the crop. The compounds of the invention can also be mixed with one or more insecticides, fungicides, bactericides, attractant acaricides or pheromones or other compounds with biological activity. The mixtures thus obtained have a broadened spectrum of activity. The mixtures with other fungicides are particularly advantageous. The fungicidal compositions of the present invention can be used to curatively or preventively control the phytopathogenic fungi of crops. Thus, according to a further aspect of the present invention, there is provided a method for curatively or preventively controlling the phytopathogenic fungi of crops characterised in that a fiingicidal composition as hereinbefore defined is applied to the seed, the plant and/or to the fruit of the plant or to the soil in which the plant is growing or in which it is desired to grow. The composition as used against phytopathogenic fungi of crops comprises an effective and non-phytotoxic amount of an active material of general formula (I). The expression "effective and non-phytotoxic amount" means an amount of composition according to the invention which is sufficient to control or destroy the fungi present or liable to appear on the crops, and which does not entail any appreciable symptom of phytotoxicity for the said crops. Such an amount can vary within a wide range depending on the fungus to be controlled, the type of crop, the climatic conditions and the compounds included in the fungicidal composition according to the invention. This amount can be determined by systematic field trials, which are within the capabilities of a person-skilled in the art. The method of treatment according to the present invention is useful to treat propagation material such as tubers or rhizomes, but also seeds, seedlings or seedlings pricking out and plants or plants pricking out. This method of treatment can also be useful to treat roots. The method of treatment according to the present invention can also be useful to treat the overground parts of the plant such as trunks, steins or stalks, leaves, flowers and fruits of the concerned plant. Among the plants that can be protected by the method according to the invention, mention may be made of cotton; flax; vine; fruit or vegetable crops such as Rosaceae sp. (for instance pip fruits such as apples and pears, but also stone fruits such as apricots, almonds and peaches), Ribesioidae sp., Juglandaceae sp., Betulaceae sp., Anacardiaceae sp., Fagaceae sp., Moraceae sp., Oleaceae sp., Actinidaceae sp., Lauraceae sp., Musaceae sp. (for instance banana trees and plantins), Ruhiaceae sp., Theaceae sp., Sterculiceae sp., Rutaceae sp. (for instance lemons, oranges and grapefruits); leguminous crops such as Solanaceae sp. (for instance tomatoes), Liliaceae sp., Asteraceae sp. (for instance lettuces), Umbelliferae sp., Cruciferae sp., Chenopodiaceae sp., Cucurbitaceae sp., Papilionaceae sp. (for instance peas), Rosaceae sp. (for instance strawberries); big crops such as Graminae sp. (for instance maize, lawn or cereals such as wheat, rice, barley and triticale), Asteraceae sp. (for instance sunflower), Cruciferae sp. (for instance colza),. Papilionaceae sp. (for instance soja), Solanaceae sp. (for instance potatoes), Chenopodiaceae sp. (for instance beetroots); horticultural and forest crops; as well as genetically modified homologues of these crops. Among the plants and the possible diseases of these plants protected by the method according to the present invention, mention may be made of: - wheat, as regards controlling the following seed diseases: fusaria (Microdochium nivale and Fitsarhtm roseum). stinking smut (Tilletia caries, Tilletia controversa or Tilletia indica), septoria disease (Septoria nodorum) and loose smut; - wheat, as regards controlling the following diseases of the aerial parts of the plant: cereal eyespot (Tapesia yalhindae, Tapesia acuiformis), take-all {Gaeumannomyces graminis), foot blight (F. culmorum, F. gramineamm), black speck (Rhizoctonia cerealis), powdery mildew (Erysiphe graminis forma specie tritici), rusts (Puccinia striiformis and Puccinia reconditd) and septoria diseases (Septoria tritici and Septoria nodorum); - wheat and barley, as regards controlling bacterial and viral diseases, for example barley yellow mosaic; * - barley, as regards controlling the following seed diseases: net blotch (Pyrenophora graminea, Pyrenophora teres and Cochliobolus sativus), loose smut (Ustilago nuda) and fusaria (Microdochium nivale and Fusarium roseum}; - barley, as regards controlling the following diseases of the aerial parts of the plant: cereal eyespot (Tapesia yallundae), net blotch (Pyrenophora teres and Cochliobolus sativus), powdery mildew (Erysiphe graminis forma specie hordei), dwarf leaf rust (Puccinia hordei) and leaf blotch (Rhynchosporium secalis); - potato, as regards controlling tuber diseases (in particular Helminthosporiurn solani, Phoma tuberosa, Rhizoctonia solani, Fusarium solani), mildew (Phytopthora infestans) and certain vimses (virus Y); - potato, as regards controlling the following foliage diseases: early blight (Alternaria solani), mildew (Phytophthora infestans); - cotton, as regards controlling the following diseases of young plants grown from seeds: damping-off and collar rot (Rhizoctonia solani, Fusarium oxyspontm) and black root rot (Thielaviopsis basicola); - protein yielding crops, for example peas, as regards controlling the - following seed diseases: anthracnose (Ascochyta pisi, Mycosphaerella pinodes), fusaria (Fusarium oxysporum), grey mould (Botrytis cinerea) and mildew (Peronospora pisi); - oil-bearing crops, for example rape, as regards controlling the following seed diseases: Phoma lingam, Alternaria brassicae and Sclerotinia sclerotiorum; - corn, as regards controlling seed diseases: (Rhizopus sp., Penicillium sp., Trichoderma sp., Aspergillus sp., and Gibberellafujikuroi); - flax, as regards controlling the seed disease: Alternaria linicola; - forest trees, as regards controlling damping-off (Fiisarhun oxysporum, Rhizoctonia solani); - rice, as regards controlling the following diseases of the aerial parts: blast disease (Magnaporthe griseci), bordered sheath spot (Rhizoctonia solani); - leguminous crops, as regards controlling the following diseases of seeds or of young plants grown from seeds: damping-off and collar rot (Fusariwn oxysporum, Fusarium roseitm, Rhizoctonia solani, Pythium sp.}; - leguminous crops, as regards controlling the following diseases of the aerial parts: grey mould (Botrytis sp.)3 powdery mildews (in particular Eiysiphe cichoracearum, Sphaerotheca fuliginea and Leveillula tauricd), fusaria (Fusarium oxysporum, Fusarium roseiuri), leaf spot (Cladosporium sp.), alternaria leaf spot (Alternaria sp.), anthracnose (Colletotrichum sp.), septoria leaf spot (Septoria sp.), black speck (Rhizoctonia solani), mildews (for example Bremia lactucae, Peronospora sp., Pseudoperonospora sp., Phytophthora sp.); - fruit trees, as regards diseases of the aerial parts: monilia disease (Monilia fructigenae, M. laxa), scab (Venturia inaequalis'), powdery mildew (Podosphaera leucotricha); - vine, as regards diseases of the foliage: in particular grey mould (Botrytis cinerea), powdery mildew (Uncinula necator), black rot (Guignardia biwelli) and mildew (Plasmopara viticola); - beetroot, as regards the following diseases of the aerial parts: cercospora blight (Cercospora beticold), powdery mildew (Eiysiphe beticold), leaf spot (Ramularia beticold). The fungicide composition according to the present invention may also be used against fungal diseases liable to grow on or inside timber. The term "timber" means all types of species of wood, and all types of working of this wood intended or construction, for example solid wood, high-density wood, laminated wood, and plywood. The method for treating timber according to the invention mainly consists in contacting one or more compounds of the present invention, or a composition according to the invention; this includes for example direct application, spraying, dipping, injection or any other suitable means. The dose of active material usually applied in the treatment according to the present invention is generally and advantageously between 10 and 800 g/ha, preferably between 50 and 300 g/ha for applications in foliar treatment. The dose of active substance applied is generally and advantageously between 2 and 200 g per 100 kg of seed, preferably between 3 and 150 g per 100 kg of seed in the case of seed treatment. It is clearly understood that the doses indicated above are given as illustrative examples of the invention. A person skilled in the art will know how to adapt the application doses according to the nature of the crop to be treated. The fungicidal composition according to the present invention may also be used in the treatment of genetically modified organisms with the compounds according to the invention or the agrochemical compositions according to the invention. Genetically modified plants are plants into whose genome a heterologous gene encoding a protein of interest has been stably integrated. The expression "heterologous gene encoding a protein of interest" essentially means genes which give the transformed plant new agronomic properties, or genes for improving the agronomic quality of the transformed plant. The compositions according to the present invention may also be used for the preparation of composition useful to curatively or preventively treat human and animal fungal diseases such as, for example, mycoses, dermatoses, trichophyton diseases and candidiases or diseases caused by Aspergillus spp., for example Aspergillus fumigatus. The aspects of the present invention will now be illustrated with reference to the following tables of compounds and examples. The following Table illustrates in a non-limiting manner examples of fungicidal compounds according to the present invention. In the following Examples, M+l (or M-l) means the molecular ion peak, plus or minus 1 a.m.u. (atomic mass units) respectively, as observed in mass spectroscopy and M (Apcl+) means the molecular ion peak as it was found via positive atmospheric pressure chemical ionisation in mass spectroscopy. (Table Removed) Examples of process for the preparation of the compound of general formula (I) Example of process A : Preparation of N-[2-(3,5-dichloro-2-pvridinvl)ethyll-2-(iodo)benzamide (compound 5) Step 1: Preparation ofter-butvl cvano(3,5-dichloro-2-pvndinvl)acerate To 50 ml of dimethoxyethane was slowly added portionwise at 0°C, 8.8 g (0.22 mol) of sodium hydride (60% dispersion in mineral oil). To this suspension, was further added dropwise at 5°C, 17 g (0.12 mol) of ter-butyl cyanoacetate in 50 ml of dimethoxyethane. The suspension was stirred for 45 mn at room temperature. To the suspension were successively added 20 g (0.11 mol) of 2,3,5-trichloropyridine, 0.59 g (1.1 mmol) of (S)-(+)-l-[(R)-2-(diphenylphosphino)ferrocenyl]ethyl-ter--butylphosphine, and l,2g (2.2 mmol) of bis(dibenzylideneacetone)palladium(0). The black mixture was heated at reflux for 5 houfs. After cooling, the reaction mixture was poured into 100 ml of IN hydrochloric acid. The aqueous phase was filtered on supersel and was extracted with ethyl acetate (3 x 200 ml). The organic phase was washed with brine and dried over magnesium sulphate. The solvent was evaporated under reduced pressure to give 38.5 g of the crude product as a brown oil. The crude product was purified by flash chromatography on silica gel (eluent: heptane/chloroforme : 6/4) to give ter-butyl cyano(3,5-dichloro-2-pyridinyl)acetate : 13 g (41%) as a yellow oil; mass spectrum: 287 (M+l). Step 2 : Preparation of(3,5-dichloro-2-pvridinvl)acetonitrile To a solution of 12 g (0.042 mol) of ter-butyl cyano(3,5-dichloro-2-pyridinyl)acetate in 50 ml of a 25/1 mixture of dimethylsulfoxide/water, was added 1.2 g (0.021 mol) of sodium chloride. The mixture was stirred for 3 hours at 130°C. After cooling, the reaction mixture was poured into ice water. The aqueous phase was extracted with ethyl acetate (3 x 250 ml) and the organic phase was washed with brine and dried over magnesium sulphate. The solvent was evaporated under reduced pressure to give 8.2 g of the crude product as a brown oil. The crude product was purified by flash chromatography on silica gel (eluent: heptane/ethyl acetate: 7/3) to give (3,5-dichloro-2-pyridinyl)acetonitrile: 5.9 g (76%) as an orange oil; mass spectrum: 185 (M-l). Step 3 : Preparation of ter-biitvl 2-(3,5-dichloro-2-vwldinvl)etlivlcarbamate To a solution of 2.8 g (0.015 mol) of (3,5-dichloro-2-pyridinyl)acetonitrile in 40 ml of methanol were rapidly added 3.9 g (0.0165 mol) of colbalt(II) chloride hexaliydrate and 6.5 g (0.03 mol) of di-ter--butyl dicarbonate. The dark solution was cooled to - 5°C and 3.96 g (0.1 mol) of sodium borohydride was added portion-wise at 0°C. The reaction mixture was stirred at room temperature for 18 hours. The reaction mixture was neutralized by 1 N hydrochloric acid and methanol was remove under reduced pressure. The aqueous phase was reextracted by dichloromethane and the organic phase was washed with brine and dried over magnesium sulphate. The solvent was evaporated under reduced pressure to give 4 g of the crude product as a brown oil. The crude product was purified by flash chromatography on silica gel (eluent: heptane/ethyl acetate: 5/1) to give ter -butyl 2-(3,5-dichloro-2-pyridinyl)ethylcarbamate: 2.0 g (46%) as a yellow oil; mass spectrum: 192 (M+l-101 (boc)). Step 4 : Preparation of hvdrochlorhide of2-(3,5-dichloro-2-pvridinvl)ethanamine To a solution of 2.4 g (8,2 mmol) of /er-butyl 2-(3,5-dichloro-2-pyridinyl)ethyl carbamate in 100 ml of dichloromethane were added 5 ml of trifluoroacetique acid. The mixture was stirred 1 hour at room temperature. The solvent was evaporated under reduced pressure to give 4.7 g of a crude yellow oil. The crude oil was redissolved in 10 ml of ethyl ether and 5.2 ml of 2N hydrochloric acid was added dropwise to precipitated the hydrochlorhide. The solid was collected by filtration, washed by ethyl ether and dried under vacuum to give 2-(3,5-dichloro-2-pyridinyl) ethanamine as its hydrochlorhide : 1.3 g (70%). Step 5: Preparation of N-f2-(3,5-dichloro-2-pwidinvl)ethvll-2-(iodo')benzamide^ fcompound 5) To a suspension of 60 mg (0.26 mmol) of the hydrochlorhide of 2-(3,5-dichloro-2-pyridinyl)ethanamine in 1 ml of dichloromethane was added successively 81 μ1 (0.58 mmol) of triethylamine and 85 mg (0.32 mmol) of 2-iodobenzoyl chloride. The mixture was stirred 18 hour at room temperature. The reaction mixture was poured into water and the pH brought to 4. The aqueous phase was extracted with ethyl acetate and the organic phase was washed with brine and dried over magnesium sulphate. The solvent was evaporated and the residue was purified by flash chromatography on silica gel (eluent: heptane/ethyl acetate: 8/2) to give N-[2-(3,5-dichloro-2-pyridinyl)ethyl]-2-(iodo)benzamide as a brown solid : 47 mg (43%) ; m.p. = 133°C. The following compounds of formula (I) are prepared according to a process identical to the one used for the preparation of compound 5, and illustrate as well the present invention: 2, 3,4,13, 16,17,21,22,23, 25 and 26. Example of process B: Preparation of N-[2-(3,5-dichIoro-2-pyridinvl)ethvll-2-(trifluoromethvltbenzamide (compound 1) Step 1: Preparation of methyl cyano(3,5-dichloro-2-pvridinvl)acetate To 100 ml of l-methyl-2-pyrrolidinone was slowly added portionwise at 0°C, 24.8 g (0.62 mol) of sodium hydride (60% dispersion in mineral oil). To this suspension, was further added dropwise at 5°C, 32.7 g (0.33 mol) of methyl cyanoacetate in 50 ml of l-methyl-2-pyrrolidinone. The suspension was stirred for 30 mn at 5°C. To the cooled suspension were then rapidly added 70 g (0.3 mol) of 2-bromo-3,5-dichloropyridine and the mixture was heated at 130°C for 5 hours. After cooling, the reaction mixture was poured into ice water. The aqueous phase was extracted with ethyl ether (3 x 300 ml) and the organic phase was washed with brine and dried over magnesium sulphate. The solvent was evaporated under reduced pressure and crude product was recrystallized in methanol to give methyl cyano(3,5-dichloro-2-pyridinyl)acetate : 24.8 g (34%) as brown crystals; m.p. = 109-110°C. Step 2 : Preparation of(3,5-dichloro-2-vvridinvl)acetomtrile To a solution of 14.45 g (0.06 mol) of methyl cyano(3,5-dichloro-2-pyridinyl)acetate in 70 ml of a 25/1 mixture of dimethylsulfoxide/water, was added 1.75 g (0.03 mol) of sodium chloride. The mixture was stirred for 4 hours at 130°C. After cooling, the reaction mixture was poured into ice water. The aqueous phase was extracted with ethyl ether (3 x 250 ml) and the organic phase was washed with brine and dried over magnesium sulphate. The solvent was evaporated under reduced pressure to give 11.2 g of the crude product as a brown oil. The crude product was purified by flash chromatography on silica gel (eluent: heptane/ethyl acetate: 7/3) to give (3,5-dichloro-2-pyridinyl)acetonitrile: 8.65 g (77%) as a yellow oil; mass spectrum: 185 (M-l). Step 3: Preparation of N-[2-(3,5-dichloro-2-pvridinyl)ethvl]-2-(trifluoromethyl)benzamide (compound 1) To a solution of 1 g (5.4 mniol) of (3,5-dichloro-2-pyridinyl)acetonitrile in 15 ml of methanol were rapidly added 1.3 g (5.9 nimbi) of colbalt(II) chloride hexahydrate and 3.9 g (10.S mmol) of 2-trifluoromethylbenzoic anhydride. The dark green solution was cooled to - 5°C and 1.4 g (37.4 mmol) of sodium borohydride was added portion-wise at 0°C. The reaction mixture was stirred at room temperature for 18 hours. The reaction mixture was neutralized by IN hydrochloric acid and methanol was remove under reduced pressure. The aqueous phase was reextracted by ethyl acetate and the organic phase was washed with brine and dried over magnesium sulphate. The solvent was evaporated under reduced pressure to give 2.6 g of the crude product as a brown oil. The crude product was purified by flash chromatography on silica gel (eluent: heptane/ethyl acetate: 7/3) to give N-[2-(3,5-dichloro-2-pyridinyl)ethyl]-2-(trifluoromethyl) benzamide: 0.80 g (41%) as white crystals; m.p. = 118°C. The following compounds of formula (I) are prepared according to a process identical to the one used for the preparation of compound 1, and illustrate as well the present invention : 10, 11,12 and 15. Example of process C/D ; Preparation of N-[2-(3-chloro-2-Dvridinvl)ethvn-2-( trifluoromethvDbenzamide (compound 6) Step 1: Preparation of (3-chloro-2-pvridinvl)acetonitrile To a solution of 55.5 ml (0.138 mol) of 2.5 M butyl lithium in 400 ml of anhydrous tetrahydrofurane at - 78°C, were added 6.22 g (0.153 mol) of acetonitrile. The reaction mixture was stirred 45 mn at - 78°C until formation of a suspension. To the resulting suspension, a solution of 3 g (0.02 mol) of 2,3-dichloropyridine in 50 ml of anhydrous tetrahydrofurane was slowly added at — 78°C and the reaction mixture was further stirred 2 hours at - 78°C. The reaction mixture was poured into 50 ml of water. The aqueous phase was extracted with dichloromethane and the organic phase was washed with water arid dried over magnesium sulphate. The solvent was evaporated under reduced pressure and the residue was purified by flash chromatography on silica gel (eluent: dichloromethane) to give (3-chloro-2-pyridinyl)acetonitrile as an oil: 1,2 g (40%); mass spectrum: 153 (M+l). Step 2: Preparation of N-[2-(3-chloro-2-pvridinvl)ethvll-2-( trifluoromethyl) benzamide (compound 6) To a solution of 0,152 g (1 mmol) of (3-chloro-2-pyridinyl)acetonitrile in 4 ml of methanol was successively added 0.238 g (1 mmol) of nickel(II) chloride hexahydrate, 0.724 g (2 mmol) of 2-trifluoromethylbenzoic anhydride and slowly added at 0°C, 0.265 g (7 mmol) of sodium borohydride. The reaction mixture was stirred at room temperature for 18 hours. The solvent was evaporated and the residue was purified by flash chromatography on silica gel (eluent: heptane/ethyl acetate: 9/1) to give N-[2-(3-chloro-2-pyridinyl)ethyl]-2-( trifluoromethyl) benzamide as an oil: 90 mg (27%); mass spectrum: 329 (M+l). The following compounds of formula (I) are prepared according to a process identical to the one used for the preparation of compound 6, and illustrate as well the present invention : 7, 8 and 9. Example of process G : Preparation of N-f2-(5-methvl-2-Pvridinvnethvll-2-(iodo)benzamide (compound 14) Step 1: Preparation of 5-methvl-2-vinylpwidine To a solution of 3 g (17.4 mmol) of 2-bromo-5-methylpyridine in 30 ml of dimethylformamide was successively added 2 g (1.7 mmol) of tetrakis (triphenylphosphine)palladium and 5.52 g (17.4 mmol) of tributyl(vinyl)tin. The reaction mixture was stirred at 120°C for IS hours. After cooling, the reaction mixture was poured into 50 ml of water saturated with potassium fluoride and stirred for 1 hour. The mixture was filtered on supersel and the aqueous phase was extracted with ethyl ether. The organic phase was washed twice with water saturated with A potassium fluoride, once with water and dried over magnesium sulphate. The solvent was evaporated under reduced pressure to give 3.5 g of a crude mixture as a yellow oil. The mixture was purified by flash chromatography on silica gel (eluent: heptane/ethyl acetate: 4/1) to give 5-methyl-2-vinyIpyridine as a yellow oil: 0.9 g (43%); mass spectrum: 120 (M+l). Step 2: Preparation of 2-[2-(5-methyl-2-pwidmyl)ethvl]-lH'isoindole-ll3(2H)-diorie 0.5 g (4.2 mmol) of 5-methyl-2-vinyJpyridine and 0.618 g (4.2 mmol) of phthalimide was added to 0.5 ml of benzyltrimethylammonium hydroxide (Triton B™) and the mixture was heated at 200°C for 3 hours. The mixture was allowed to cool to room temperature and was directly purified by flash chromatography on silica gel (eluent: heptane/ethyl acetate: 5/1) to give 2-[2-(5-methyl-2-pyridinyl)ethyl]-7/:/-isoindole-ls3(2/f)-dione as white crystals : 0.680 g (59%) ; mass spectrum: 267 (M+l). Step 3: Preparation of2-f5-methvl-2-pvridinvl)ethanamine To a solution of 0.5 g (1.88 mmol) of 2-[2-(5-methyl-2-pyridinyl)ethyl]-/H-isoindole-l,3(.2H)-dione in 5 ml of methanol, was added 0.45 g (7.5 mmol) of hydrazine hydrate. The reaction mixture was reflux for 1 hour until completion. The solvent was removed under vacuum and the residue was acidified with 1 N hydrochloric acid. The solid phthalhydrazide was removed by filtration. The filtrate was basified with sodium hydroxyde and extracted by chloroform. The organic phase was washed with water and dried over magnesium sulphate. The solvent was evaporated to give pure 2-(5-methyl-2-pyridinyl)ethanamine as a yellow oil: 0.240 g (94%); mass spectrum: 137 (M-H). Step 4: Preparation of N-[2-(5-methvl-2-pvridinvl)ethvll-2-(iodo)benzamide (compound 14) To 0.06 mg (0.44 mmol) of 2-(5-methyl-2-pyridinyl)ethanamine in solution in 3 ml of acetonitrile, was successfully added 0.117 mg (0.44 mmol) of 2-iodobenzoyl chloride and 0.078 mg (0.44 mmol) of potassium carbonate. The reaction mixture was stirred at room temperature for 18 hours. The reaction mixture was poured into aqueous potassiumcarbonate and the aqueous phase was extracted with ethyl acetate. The organic phase was washed with brine and dried over magnesium sulphate. The solvent was evaporated under reduced pressure to give pure N-[2-(5-methyl-2-pyridinyl)ethyl]-2-(iodo)benzamide as beige crystals : 0.08 g (53%); mass spectrum: 367 (M-H). The compounds 18, 19, 20 and 24 are prepared according to a process identical to the one used for the preparation of compound 14, and illustrate as well the present invention. Examples of biological activity of the compound of general formula (I) Example A : in vivo test onAlternaria brassicae (Leaf spot of crucifers') The active ingredient tested is prepared by potter homogenisation in a concentrated suspension type formulation at 100 g/1. This suspension is then diluted with water to obtain the desired active material concentration. Radish plants (Pernot variety) in starter cups, sown on a 50/50 peat soil-pozzolana substrate and grown at 18-20°C, are treated at the cotyledon stage by spraying with the aqueous suspension described above. Plants, used as controls, are treated with an aqueous solution not containing the active material. After 24 hours, the plants are contaminated by spraying them with an aqueous suspension of Alternaria brassicae spores (40,000 spores per cm3). The spores are collected from a 12 to 13 days-old culture. The contaminated radish plants are incubated for 6-7 days at about 18°C, under a humid atmosphere. Grading is carried out 6 to 7 days after the contamination, in comparison with the control plants. Under these conditions, good (at least 50%) or total protection is observed at a dose of 330ppm with the following compounds: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13,14, 15, 16, 17, 18, 19, 20, 21, 24, 25, 26, 27, 28, 30, 31, 32, 34, 35, 36, 37, 38, 40, 41, 43, 45, 47, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 67 and 68. Example B : in vivo test on Erysiphe graminis f. sp. tritici (powdery mildew of wheaf) The active ingredient tested is prepared by potter homogenisation in a concentrated suspension type formulation at 100 g/1. This suspension is then diluted with water to obtain the desired active material concentration. Wheat plants (Audace variety) in starter cups, sown on 50/50 peat soil-pozzolana substrate and grown at 12°C, are treated at the 1-leaf stage (10 cm tall) by spraying with the aqueous suspension described above. Plants, used as controls, are treated with an aqueous solution not containing the active material. After 24 hours, the plants are contaminated by dusting them with Eiysiphe graminis f. sp. tritici spores, the dusting being carried out using diseased plants. Grading is carried out 7 to 14 days after the contamination, in comparison with the control plants. Under these conditions, good (at least 50%) or total protection is observed at a dose of 330 ppm with the following compounds: 1, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 18,38,50, 43 and 45. Example C : in vivo test on Botrvtis cinerea (cucumber Grey mould) The active ingredient tested is prepared by potter homogenisation in a concentrated suspension type formulation at 100 g/1. This suspension is then diluted with water to obtain the desired active material concentration. Cucumber plants (Marketer variety) in starter cups, sown on a 50/50 peat soil-pozzolana substrate and grown at 18- 20°C, are treated at the cotyledon Zll stage by spraying with the aqueous suspension described above. Plants, used as controls, are treated with an aqueous solution not containing the active material. After 24 hours, the plants are contaminated by depositing drops of an aqueous suspension of Botrvtis cinerea spores (150,000 spores per ml) on upper surface of the leaves. The spores are collected from a 15-day-old culture and are suspended in a nutrient solution composed of: - 20 g/L of gelatin - 50 g/L of cane sugar - 2 g/L of NH4N03 -1 g/L of KH2P04 The contaminated cucumber plants are settled for 5/7 days in a climatic room at 15-11°C (day/night) and at 80% relative humidity. Grading is carried out 5/7 days after the contamination, in comparison with the control plants. Under these conditions, good (at least 50%) or total protection is observed at a dose of 330 ppm with the following compounds: 1, 2, 3, 4, 5, 6, 9, 10, 13, 18, 21, 22, 23, 25, 26, 27, 28, 29, 32, 34, 35, 38, 40, 43, 44, 45, 46, 47, 50, 51, 52, 53, 57 and 62. Example D: in vivo test on Pyrenophora teres (Barley Net blotch) The active ingredient tested is prepared by potter homogenisation in a concentrated suspension type formulation at 100 g/1. This suspension is then diluted with water to obtain the desired active material concentration. Barley plants (Express variety) in starter cups, sown on a 50/50 peat soil-pozzolana substrate and grown at 12°C, are treated at the 1-leaf stage (10cm tall) by spraying with the aqueous suspension described above. Plants, used as controls, are treated with an aqueous solution not containing the active material. After 24 hours, the plants are contaminated by spraying them with an aqueous suspension of Pyrenophora teres spores (12,000 spores per ml). The spores are collected from a 12-day-old culture .The contaminated barley plants are incubated for 24 hours at about 20°C and at 100% relative humidity, and then for 12 days'at 80% relative humidity. * Grading is carried out 12 days after the contamination, in comparison with the control plants. Under these conditions, good (at least 50%) or total protection is observed at a dose of 330 ppm with the following compounds: 1, 2, 3, 4, 5, 9, 10, 11, 12, 13, 16,18, 19, 21, 28, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 45, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 65, 67, and 68. The N- {1 -methylcarbamoyl-2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-ethyl}-4-phenylbenzamide disclosed by Patent Application WO 01/11965 (see compound 316 in Table D) showed poor effectiveness on Alternaria brassicae, and zero effectiveness on Botrytis cinerea at 330 ppm; the N-{l-ethylcarbamoyl-2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]ethyl}-3-nitrobenzamide also disclosed by Patent Application WO 01/11965 (see compound 307 in Table D) showed poor effectiveness on Alternaria brassicae and zero effectiveness on Botrytis cinerea at 330 ppm; the N-{l-ethylcarbamoyl-2-[3-chloro-5-(trifluoroniethyl)-2-pyridinyl]-ethyl}-benzamide and the N-{l-methylcarbamoyl-2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]ethyl}-benzamide also disclosed by Patent Application WO 01/11965 (see compounds 304 and 314 in Table D) showed zero effectiveness on Botrytis cinerea at 330 ppm; and the N-{l-ethylcarbamoyl-2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]ethyl}-4-chlorobenzamide, the N-{ l-ethylcarbamoyl-2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]ethyl}-2-bromobenzamide and the N-{1-methylcarbamoyl-2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]ethyl}-4-methoxybenzamide also disclosed by Patent Application WO 01/11965 (see compounds 306, 310 and 315 in Table D) showed zero effectiveness on Botrytis cinerea at 330 ppm. We claim: 1. 2-pyridinylethylbenzamide compounds of general formula (1) (Formula Removed) in which n is 1, 2 or 3; - X is the same or different and is a hydrogen atom, a halogen atom, a nitro group, a cyano group; a hydroxy group, an amino group, a sulfanyl group, a pentafiuoro-X6-sulfanyl group, a formyl group, a formyloxy group, a formylamino group, a carboxy group, a carbamoyl group, a N-hydroxycarbamoyl group, a carbamate group, a (hydroxyimino)-C1-C6-alkyl group, a C1-C8-alkyl, a C2-C8-alkenyl, a C2-C8-alkynyl, a C1-C3-alkylamino, a di-GrC3-aikylamino, a C1-C8-alkoxy, a C1-C8-halogenoalkoxy having 1 to 5 halogen atoms, a C1-C3-alkylsulfanyl, a C1-C8-halogenoalkylsulfanyl having 1 to 5 halogen atoms, a C2-C3-alkenyloxy, a C1-C3-halogenoalkenyloxy having 1 to 5 halogen atoms, a C3-C8-alkynyloxy, a C3-Cg-halogenoalkynyloxy having 1 to 5 halogen atoms, a C3-C8-cycloalkyl, a C3-C8-halogenocycloalkyl having 1 to 5 halogen atoms, a C1-C8-alkylcarbonyl, a C1-C3-halogenoalkylcarbonyl having 1 to 5 halogen atoms, a C1-C8-alkylcarbamoyl, a di-C1-C8-alkylcarbamoyl, a (N-C1-C8-alkyl)oxycarbamoyl, a C1-C3-alkoxycarbamoyl, a (N-C1-C8-alkyl)-C1-C8-aikoxycarbamoyl, a C1-C8-alkoxycarbonyl, a C1-C8-halogenoalkoxycarbonyl having 1 to 5 halogen atoms, a C1-C8-alkylcarbonyloxy, a C1-C8-halogenoalkylcarbonyloxy having 1 to 5 halogen atoms, a C1-C8-alkylcarbonylamino, a C1-C3-halogenoalkylcarbonylarnino having 1 to 5 halogen atoms, a C1-C8-alkylaminocarbonyloxy, a di-C1-C8-alkylaminocarbonyloxy, a C1-C8-alkyloxycarbonyloxy, a C1-C8-alkylsulphenyl, a C1-C8-halogenoalkylsulphenyl having 1 to 5 halogen atoms, a C1-C8-alkylsulphinyl, a C1-C8-halogenoalkylsulphmyl having 1 to 5 halogen atoms, a C1-C8-alkylsulphonyl, a C1-C8-halogenoalkyl-sulphonyl having 1 to 5 halogen atoms, a (C1-C6-alkoxyimino)-C1-C6-alkyl, a (C1-C6-alkenyloxyimino)-C1-C6-alkyI, a (C1-C6-alkynyloxyimino)-C1-C6-aIkyl, a (bewzyloxyimino)-C1-C6-alkyl, a benzyloxy, a benzylsulfanyl, a benzylamino, a phenoxy, a phenylsulfanyl or a phenylammo; - R is a hydrogen atom, a halogen atom, a nilro group, a cyano group, a hydroxy group, an amino group, a sulfanyl group, a pentafiuoro-6-suIfanyl group, a formyl group, a formyloxy group, a formylamino group, a carboxy group, a carbamoyl group, a N-hydroxycarbamoyl group, a carbamate group, a (hydroxyimko)-C1-C6-alkyl group, a C1-C8-alkyl, a C1-C8-alkenyl, a C2-C3-alkynyl, a C1-Cralkylamino, a di-C1-C8-alkylamino, a C1-C8-alkoxy, a C1-C3-halogenoalkoxy having 1 to 5 halogen atoms, a C1-C3-alkylsuifanyl, a C1-C8-halogenoalkylsulfanyl having 1 to 5 halogen atoms, a C2-C8-alkenyloxy, a C1-C3-halogenoalkenyloxy having 1 to 5 halogen atoms, a C1-C8-alkynyloxy, a C3-C8-halogenoalkynyloxy having 1 to 5 halogen atoms, a C3-C8-cycloalkyl, a C1-C3-halogenocycloalkyI having I to 5 halogen atoms, a C1-C8-alkylcarbonyl5 a C1-C1-halogenoalkylcarbonyl having 1 to 5 halogen atoms, a C1-C3-alkylcarbamoyl, a di-C1-C3-alkylcarbamoyl, a N-C1- Cg-alkyloxycarbamoyl, a C1-C8-alkoxycarbamoyl, a N-C1-C8-alkyl-C1-C8- alkoxycarbamoyi, a C1-C8-alkoxycarbonyl, a C1-C8-halogenoalkoxycarbonyl having 1 to 5 halogen atoms, a C1-C8-alkylcarbonyloxy, a C1-C8-halogenoalkylearbonyloxy having 1 to 5 halogen atoms, a C1-C8-alkylcarbonylamino, a C1-C8- halogenoalkylcarbonylamino having 1 to 5 halogen atoms, a C1-C8- alkyiaminocarbonyloxy, a di-C1-C8-alkylaminocarbonyloxy, a C1-C3- alkyloxycarbonyloxy, a C1-C8-alkylsulphenyl, a C1-C8-halogenoalkylsulphenyl having 1 to 5 halogen atoms, a C1-Cralkylsulphinyl, a C1-C8-halogenoalkylsulphinyl having 1 to 5 halogen atoms, a C1-C8-alkylsulphonyl, a C1-C8-halogenoalkyl- sulphonyl having 1 to 5 halogen atoms, a (C1-C6-alkoxyirnino)-C1-C6-alkyl, a (C1- C6-alkenyloxyimino)-C1-C6-alkyl, a (C1-C6-alkynyloxyimino)-C1-C6-alkyl, a (benzyloxyimino)-C1-C6-alkyi, a benzyloxy, a benzylsulfanyl optionally substituted with 1 to 5 halogen atoms, a benzylamino, a phenoxy, a phenylsulfanyl optionally substituted with 1 to 5 halogen atoms or a phenylamino; with the proviso that X and R1 are not both a hydrogen atom; - R2 and R3 are the same or different and are a hydrogen atom, a halogen atom, a cyano group, a hydroxy group, a C1-C8-alkyl, a C1-C8-halogenoalkyl having 1 to 5 halogen atoms, a C2-c8-alkenyl, a C1-C6-alkoxy, a C1-C3-alkylsulfanyl, a Cr C3-alkylsulfenyl, a C1-C8-alkyisulftnyl, a C1--aikoxycarbonyl, a C1-C8- alkylcarbonyloxy or a C1-C8-alkylcarbonylamino; or R2 and R3 may together form a 3-, 4-, 5- or 6-membered carbocycle; - R and R3 are the same or different and are a hydrogen atom, a halogen atom, a cyano group, a C1-C6-alkyl or a C1-C6-halogenoalkyI having 1 to 5 halogen atoms; or R4 and R5 may together form a 3-, 4-, 5- or 6-membered carbocycle; - R is a hydrogen atom, a cyano group, a formyl group, a hydroxy group, a C1-C3-alkyI, a C1-Cb-halogenoalkyl having 1 to 5 halogen atoms, a C1-C6-alkoxy, a C1-C6-halogenoalkoxy having 1 to 5 halogen atoms, a C3-C6-cycloalkyl, a C3-C6- halogenocycloalkyl having 1 to 5 halogen atoms, a C1-C3-alkenyl, a C2-C8-alkynyl, a C1-C8-alkoxy-C1-C6-alkyl, a C1-C6-cyanoalkyl, a C1-C3-aminoalkyl, a C1-C6- alkylamino-C1-C3-alkyl, a di-C1-C6-alkylamino-C1-C3-alkyl, a C1-C6-alkylcarbonyl, a C1-C6-halogenalkylcarbonyl having 1 to 5 halogen atoms, a C1-C6- alkyloxycarbonyl, a C1-C6-benzyloxycarbonyl, a C1-C6-alkoxy-C1-C6-alkylcarbonyl, a C1-C8-alkylsulfonyl or a C1-C3-halogenoalkylsulfonyl having 1 to 5 halogen atoms; - p is 1, 2, 3 or 4; - Y is a hydrogen atom; and - R is a halogen atom, a nitro group, a cyano group, an amino group, a sulfanyl group, a pentafluoro--sulfanyl group, a formyl group, a formyloxy group, a formylammo group, a carboxy group, a C1-C3-alkyl, a C1-C8-halogenoalkyl having 1 to 5 halogen atoms, a C2-C3-alkenyl, a C2-C8-alkynyl, a C1-C3-alkylamino, a di-C1-C1-alkylamino, a C1-C8-alkoxy, a C1-C3-halogenoalkoxy having 1 to 5 halogen atoms, a C1-C3-alkoxy-C2-C8-alkenyl, a C1-C8-alkylsulfanyl, a C1-C3-halogenoalkylsulfanyl having 1 to 5 halogen atoms, a C1-C8-alkoxycarbonyl, a C1-C8-halogenoalkoxycarbonyl having 1 to 5 halogen atoms, a C1-C8-alkylcarbonyloxy, a C1-C8-halogenoalkylcarbonyloxy having 1 to 5 halogen atoms, a C1-C8-alkylsulphenyl, a C1-C8-halogenoalkylsulphenyl having 1 to 5 halogen atoms, a C1-C8-alkylsulphinyl, a C1-C8-halogenoalkylsulphinyl having 1 to 5 halogen atoms, a C1-C8-alkylsulphonyI, a C1-C8-halogenoalkylsulphonyl having 1 to 5 halogen atoms or a C1-C8-alkylsulfonamide; as well as its salts, N-oxydes, metallic and metalloidic complexes. 2. A compound as claimed in claim 1, wherein R1 is a hydrogen atom or a halogen atom. 3. A compound as claimed in claim 1 or 2, wherein n is 1 or 2. 4. A compound as claimed in any of the claims 1 to 3, wherein X is a halogen atom or a C1-C3-alkyl. 5. A compound as claimed in any of the claims 1 to 4, wherein the 2-pyridyl is substituted by X in 3-and/or in 5-position. 6. A compound as claimed in any of the claims 1 to 5, wherein R7 is a halogen atom, a C1-C3-alkyl or a C1-C3-halogenoalkyl having 1 to 5 halogen atoms. 7. A compound as claimed in any of the claims 1 to 6, wherein p is 1 or 2. 8. A compound as claimed in claim 7, wherein p is 1. 9. A compound as claimed in any of the claims 1 to 8, wherein the phenyl is substituted by Y preferentially first in para position. 10. A process (A) for the preparation of compound of general formula (la) (Formula Removed) wherein R1, R2, R7, X, Y, n and p are as defined in claim 1; R3 is a C1-C6 alkyl; which comprises - a first step according to reaction scheme A-I: Scheme A-l (Scheme Removed) in which R1, R2, X and n are as defined in claim 1; R8 is a C1-C6 alkyl, a C1-C6 haloalkyl, a ben2yl, 4-methoxybenzyl or pentafluorophenyl; U is a leaving group chosen as being a halogen, a C1-C6 alkylsulfonate or a C1-C6 haloalkylsulfonate; comprising the arylation of a cyanoacetate derivative of general formula (III) by a pyridine derivative of general formula (II), to provide a 2-(pyridyl)cyanoacetate derivative of general formula (IV), in the presence of a base of the kind such as herein described at a temperature of from 0°C to 200°C; a second step according to reaction scheme A-2: Scheme A-2 (Scheme Removed) in which R1, R2, X, n are as defined in claim 1; R3 is a hydrogen atom; R8 is a C1-C6 alkyl, a C1-C6 haloalkyl, a benzyl, 4-methoxybenzyl or pentafluorophenyl; comprising a basic hydrolysis, an acidic hydrolysis or a displacement by an halide of a compound of general formula (IV) in the same or a different pot to provide, upon heating at a temperature of from 40°C to reflux, a 2-pyridylacetonitrile derivative of general formula (Va); a third step according to reaction scheme A-3: Scheme A-3 (Scheme Removed) in which R1, R2, X and n are as defined in claim 1; R3 is a C1-C6 alkyl; W is a halogen atom, a C1-C6 alkylsulfonate, a C1-C6 haloalkylsulfonate or a 4-methyl-phenylsulfonate, comprising the alkylation of a compound of general formula (Va) by a reagent of general formula (XVII) to provide a compound of general formula (Vb); a fourth step according to reaction scheme A-4: Scheme A-4 (Scheme Removed) in which R1, R2, X and n are as defined in claim 1; R3 is a hydrogen atom or a C1-C6 alkyl; L1 is a leaving group is a leaving group chosen as being a -OR8 group or a - OCOR8 group, R8 being a C1-C6 alkyl, a C1-C6 haloalkyl, a benzyl, 4-methoxybenzyl or pentafluorophenyl; PG represents a protecting group which may be a -COOR8 group or -COR8 group, R8 being a C1-C6 alkyl, a C1-C6 haloalkyl, a benzyl, 4-methoxybenzyl or pentafluorophenyl; comprising the reduction, by hydrogenation or by an hydride donor, of a compound, of general formula (Va) or (Vb), in the presence of a catalyst of the kind such as herein described and in the presence of a compound of general formula (VI) to produce a compound of general formula (VII), at a temperature of from 0°C to 150°C and under a pressure of from I bar and 100 bar; a fifth step according to reaction scheme A-5: Scheme A-5 (Scheme Removed) in which R1, R2, X and n are as defined in claim 1; R3 is a C1-C6 alkyl; PG represents a protecting group which may be a -COOR8 group or -COR8 group, R8 being a C1-C6 alkyl, a C1-C6 haloalkyl, a benzyl, 4-methoxybenzyl or pentafluorophenyl; comprising a deprotection reaction, in an acidic or in a basic medium, of a compound of general formula (VII) to provide an amine derivative of general formula (Villa) or one of its salt; a sixth step according to reaction scheme A-6: Scheme A-6 (Scheme Removed) in which R1, R2, R7, X, Y, n and p are as defined in claim 1; R3 is a C1-C6 alkyl; L2 is a leaving group chosen as being a halogen atom, a hydroxyl group, an OR8 group, an OCOR8 group, R8 being a C1-C6 alkyl, a C1-C6 haloalkyl, a benzyl, 4-methoxybenzyl or pentafluorophenyl: or a group of o (Formula Removed) formula comprising a coupling reaction of an amine derivative of general formual (Villa) or one of its salt, with a carboxylic, acid derivative of formula (IX) to provide a compound of general formula (la). LI. Fungicidal composition comprising 0.05 to 99%, by weight of a compound as claimed in claim 1 and an agriculturally acceptable support.

Documents:

5569-DELNP-2005-Abstract-(05-03-2009).pdf

5569-DELNP-2005-Abstract-(19-03-2009).pdf

5569-delnp-2005-abstract.pdf

5569-DELNP-2005-Claims-(05-03-2009).pdf

5569-DELNP-2005-Claims-(19-03-2009).pdf

5569-delnp-2005-claims.pdf

5569-DELNP-2005-Correspondence-Others-(05-03-2009).pdf

5569-delnp-2005-correspondence-others.pdf

5569-delnp-2005-description (complete).pdf

5569-DELNP-2005-Form-1-(05-03-2009).pdf

5569-DELNP-2005-Form-1-(19-03-2009).pdf

5569-delnp-2005-form-1.pdf

5569-delnp-2005-form-18.pdf

5569-DELNP-2005-Form-2-(05-03-2009).pdf

5569-DELNP-2005-Form-2-(19-03-2009).pdf

5569-delnp-2005-form-2.pdf

5569-DELNP-2005-Form-3-(05-03-2009).pdf

5569-delnp-2005-form-3.pdf

5569-delnp-2005-form-5.pdf

5569-DELNP-2005-GPA-(05-03-2009).pdf

5569-delnp-2005-gpa.pdf

5569-delnp-2005-pct-101.pdf

5569-delnp-2005-pct-210.pdf

5569-delnp-2005-pct-304.pdf

5569-DELNP-2005-Petition-137-(05-03-2009).pdf

5569-DELNP-2005-Petition-138-(05-03-2009).pdf

abstract.jpg