Title of Invention

BIPHENYL AMIDELACTAM DERIVATIVES AS INHIBITORS OF 11 - BETA - HYDROXYSTEROID DEHYDROGENASE 1

Abstract

The present invention discloses novel compounds of Formula: possessing I 1β-1 ISO type I antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia. metabolic syndrome, cognitive disorders, and other conditions associated with 11β-HSD

Full Text

FORM 2 THE PATENTS ACT, 1970 (39 of 1970) & THE PATENTS RULES, 2003 COMPLETE SPECIFICATION (Sec section 10, rule 13) "BIPHENYL AMIDELACTAM DERIVATIVES AS INHIBITORS OF 11 - BETA - HYDROXYSTEROID DEHYDROGENASE 1" ELI LILLY AND COMPANY, a corporation of the Stale of Indiana, having a principal place of business at Lilly Corporate Center. City of Indianapolis. Stale of Indiana 46285, United Slates of America. The following specification particularly describes the invention and the manner in which it is to be performed. WO 2007/124337 P BIPHENYL AMIDE LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 This application claims the benefit of U.S. Provisional Application No. 60/745,3 II, filed April 21, 2006. 5 This invention relates to compounds that are inhibitors of 11 -B-hydroxysteroid dehydrogenase type 1 ("11-β-HSD1"), and to pharmaceutical compositions thereof, and the uses of these compounds and compositions in the treatment of the human or animal body, and to novel intermediates useful in preparation of the inhibitors. The present compounds show potent and selective inhibition of 11-B-HSD1, and as such arc useful in 10 the treatment of disorders responsive to the modulation of 1 1-p-HSDl, such as diabetes, metabolic syndrome, cognitive disorders, and the like. Glucocorticoids acting in the liver, adipose tissue, and muscle, arc important regulators of glucose, lipid, and protein metabolism. Chronic glucocorticoid excess is associated with insulin resistance, visceral obesity, hypertension, and dyslipidemia, which !5 also represent the classical hallmarks of metabolic syndrome. 11-P-HSD1 catalyses the conversion of inactive cortisone to active Cortisol, and has been implicated in the development of metabolic syndrome. Evidence in rodents and humans links 11-B-HSDl to metabolic syndrome. Evidence suggests that a drug which specifically inhibits 11-β-HSD1 in type 2 diabetic patients will lower blood glucose by reducing hepatic 20 gluconeogenesis, reduce central obesity, improve atherogenic lipoprotein phenotypes. iower blood pressure, and reduce insulin resistance. Insulin effects in muscle will be enhanced, and insulin secretion from die beta cells of the islet may also be increased. Evidence from animal and human studies also indicates that an excess of glucocorticoids impair cognitive function. Recent results indicate that inactivation of 11-P-HSDt 25 enhances memory function in both men and mice. The 11-p-HSD inhibitor carbcnoxolonc was shown to improve cognitive function in healthy elderly men and type 2 diabetics, and inactivation of the 11-P-HSD1 gene prevented aging-induced impairment in mice. Selective inhibition of II-P-HSD1 with a pharmaceutical agent has recently been shown to improve memory retention in mice. 30 A number of publications have appeared in recent years reporting agents that inhibit 11-p-HSDl. Sec International Application WO2004/056744 which discloses WO 2007/124337 PCT/US2007/066921 adamantyl acetamidcs as inhibitors of 11-P-HSD, international Application WO2005/108360 which discloses pyrrol id in-2-one and piperidin-2-one derivatives as inhibitors of 11-p-HSD. and International Application WO2005/108361 which discloses adamantyl pyrrolidin-2-one derivatives as inhibitors of I I-β-HSD. In spite of the number 5 of treatments for diseases that involve 11-P-HSD I. the current therapies suffer from one or more inadequacies, including poor or incomplete efficacy, unacceptable side effects, and contraindications for certain patient populations. Thus, there remains a need for an improved treatment using alternative or improved pharmaceutical agents that inhibit 11-β-HSD1 and treat the diseases that could benefit from 11 -P-HSD ] inhibition. The present 10 invention provides such a contribution to the art based on the finding that a novel class of compounds has a potent and selective inhibitory activity on 11-P-HSDl. The present Invention is distinct in the particular structures and their activities. There is a continuing need for new methods of treaiing diabetes, metabolic syndrome, and cognitive disorders. and it is an object of this invention to meet these and other needs. 15 The present invention provides a compound structurally represented by formula I: (1) or a pharmaceutically acceptable sail (hereof, wherein Rl is 20 , wherein the dashed line represents the point of attachment to the R1 position in formula I; R2is -H, -halogen, -CHt {optionally substituted with I to 3 halogens), or -O-CH3 (optionally substituted with I to 3 halogens); 25 R+is WO 2007/124337 PCT/US2007/066921 ^H -halogen, -CH?(optionally substituted with 1 to 3 halogens), or -0-CH? (optionally substituted with 1 to 3 halogens); Rd Ls -H or -halogen; R5is (C1-C3)alkyl-N(R20XR20).-(C,-C3)alkyl-N+(O'KCH3)2, -(C1-C3)a]kyI-C(O)N(R42)(R43,),-CH(C(0)OH)(CH2OR20), -CH(C(O)OH)(CH2N(R20){R20)),-(C1-C3)alkyl-C(0)O-R20, attachment to the position indicated by R6; HET1 is position indicated by HET1; HET2 is WO 2007/12-J337 PCT/US200 7/066921 position indicated by HET2; R7is 5 -H, -(C1-C3)alkyl(optionally substituted with I to 3 halogens), or -(C1-C3)alkyl-0-R20; R8is -H. -OH. -(C1-C6)alkyl(optionally substituted with 1 to 3 halogens). (C1-C3))alkyl-0-R2u, -C(0)-(C3C4))alkyl(oplionaily substituted with ) to 3 10 halogens), -C(0)0-(C1-C4)alkyl(optionally substituted with i to 3 halogens), or -C(0)-N(Rz")(R2"); R9-is -H.-halogen. -CH3 (optionally substituted with 1 to 3 halogens), or -O-CH3(optionally substituted with 1 to 3 halogens); 15 R10 is independently at each occurrence -H, or -halogen; R11 is independently at each occurrence -H, -CH3 or -CH2-CH3; R 20is independently at each occurrence -H, or -(C) -C4)alkyl(optionally substituted with 1 to 3 halogens); R2' is independently at each occurrence -H, -halogen, or -(C1-C4)alkyl(optionally 20 substituted with I to 3 halogens); R22 is independently at each occurrence -H, or -(C1-C4)alkyl(optionally substituted with 1 to 3 halogens); R27 is independently at each occurrence -H. -(C1-C4)alkyl, or -C(0)0-(C1-C4))alky]; R24 is independently at each occurrence -H, -halogen, or (C1-C6)alkyl(optionally 25 substituted with 1 to 3 halogens); R41M is independently at each occurrence -H, -halogen, or -(C1-C6)alkyl(optionally substituted with 1 to 3 halogens); andi- WO 2007/124337 PCT/US2007/066921 R41 is independently ai each occurrence -H, or -(C1-C6)alkyl(optionally substituted with \ to 3 halogens); provided the compound is not {[3'-Ch1oro-4'-( I -cyclohexyl-2-oxo-pyrrohdin-3-ylmethyly biphcnyl-4-carbonyl]-arnino}-acetic acid, 4- {[3'-Chloro-4'-( I -cyclohexyl-2-oxo-5 pyrrolidin-3-ylmethyl)'biphenyi-4-caTbonyl]-amino}-butyric acid. 3'-Chloro-4'-{l- cyclohexyl-2-oxo-pyrrolidin-3-ylmethyl)-biphenyl-4-carboxylic acid piperidin-4-ylamide, or 3-(3-Chloro-4'-(4-methyl-piperazine-1 -carbonyl)-biphenyl-4-ylmethyl]-1 -cyclohexyl-pyrrolidin-2-one. The present invention provides compounds of formula 1 thai are useful as potent 10 and selective inhibition of 11-β-HSDl. The present invention further provides a pharmaceutical composition which comprises a compound of Formula ]. or a pharmaceutical sail thereof, and a pharmaceutically' acceptable carrier, diluent, or excipiem. In addition, the present invention provides a method for the treatment of metabolic syndrome, and related disorders, which comprise administering to a patient in 15 need thereof an effective amouni of a compound of formula 1 or a pharmaccuticaily acceptable salt thereof. In one embodiment, the present invention provides compounds of Formula I or a pharmaceulically acceptable salt thereof as described in detail above. While all of the compounds of the present invention are useful, certain of the compounds are particularly 20 interesting and arc preferred. The following listings set out several groups of preferred compounds. In another embodiment the invention provides a compound structurally represented by formula J, or a pharmaceutically acceptable salt thereof, wherein Rl is 25 , wherein the dashed line represents the point of attachment to the R1 position in formula I; R2 is -halogen: R3 is -halogen; R4 is -H or -halogen; 30 R5 is WO 2007/124337 PCT/US2007/066921 10 R6is or ; wherein the dashed line represents the point of attachment to the R position in formula I; -H, -(C1-C3)aIkyl(optionally substituted with 1 to 3 halogens), -((C1-C3)alkyl-0-R20 , -(C1-C3)alkyl-pyrrolidinyl, phenyl, -HET1, -HET2, -CH2-phenyl, -CH2-HET', -CH2-HET2, -((C1-C3)alkyl-NCR20)(R20)-(C1-C3)alkyl-N(O)(CH3)2, -(C,-C3)a]ky]-C(0)N(R4,)(R41), -CH(C(0)OH)(CH2OR20), -CH(C(0)OH)(CH2N(R20)(R20)),-{C1-C3)alkyl-C(O)O-R20T WO 2007/124337 PCT/US2007/066921 N , wherein the dashed line indicates the point of attachment to the position indicated by RET1; 10 HET2 is or , wherein the dashed line indicates the point of attachment to the position indicated by HET2; WO 2007/124337 PCT/US2007/066921 R7is -H, -(C1-C3)alkyl(optionally substituted with 1 to 3 halogens), or -(C1-C3)alkyl-O-R20; R8is 5 -H, -OH, -(C1-C6)alkyl(optioniilly substituted with 1 to 3 halogens), -(C1-C3))aIkyl-0-R2°, -C(0)-(C1-C4)alky](optionaIly substituted with I to 3 halogens), -C(0)0-(C1,-C4)alkyl(optionally substituted with 1 to 3 halogens), or -C(O)-N(R20)(R2°); R9is 10 -H,-halogen, -CH3 (optionally substituted with ] to 3 halogens), or -0-CH? (optionally substituted with 1 to 3 halogens); R'^is independently at each occurrence -H or-halogen: R1' is independently at each occurrence-H, -CH,or -CH2-CH3; R20is independently ai each occurrence -H or -(C1-C4)alkyl(optionally substituted with 1 15 to 3 halogens); R21 is independently at each occurrence -H, -halogen, or -(C1-C4)alkyl(optionally substituted with 1 to 3 halogens); R22 is independently at each occurrence -H, or -{C1-C6)alky(optionally substituted with I . 10 3 halogens); 20 R23 is independently at each occurrence -H, -(C1-C4)alkyl, or -C(O)0-(C1-C4))alkyl; R24 is independently at each occurrence -H, -halogen, or -(C1-C6alkyl(optionally substituted with 1 to 3 halogens); R31 is independently at each occurrence -H, -halogen, or -(Ct-C&)alkyl(optionaIly substituted with 1 to 3 halogens); and 25 R4i is independently at each occurrence -H or -(C1-C6)lkyKoptionally substituted with 1 to 3 halogens) In another embodiment the invention provides a compound structurally represented by formula 1, or a pharmaceutical^ acceptable salt thereof, wherein R1 is WO 2007/124337 PCT/US2007/066921 , wherein the dashed line represents the point of attachment to the R1 position in formula I; R2 is -halogen; R3 is -halogen; 5 R4 is -H or -halogen; R5is 10 or ; wherein the dashed line represents the point of attachment to the Rs position in formula 1; R6is WO 2007/124337 PCT/DS2007/066921 -H, -((C1-C3)alkylfoptionally substituted with I to 3 halogens), -((C1-C3)alkyl-O-R30 , -(C1-C3))a!kyI-pyrro1idinyl, phenyl, -HET1, -HET\-CHrphenyl -CH2-HET1. -CH2-HET2 -(C1-C3)alkyl-N(RM)(R2%-(C,-C.0alkyl-N,(O-)(CH3)2. ■ -(C,-C3)alkyl-aO)N(R4l)(R41),-CH(C(0)OH)(CH)OR20), -CH(C(O)OH ){CH3N(R30)(R20)).-(C1-C3)alkyl-CtOO-R20, wherein the dashed line indicates the point of attachment to the position indicated by R HET1 is "N , wherein the dashed line indicates the point of attachment to the position indicated by HET1: HET2 is WO 2007/124337 PCT/US2OO7/066921 wherein the dashed line indicates the point of attachment to the position indicated by HET ; R7is 5 -H, (C1-C3)alky](optionally substituted with 1 to 3 halogens), or -(C2-C3)alkyl-O-R20; R8is -H. -OH. -('C1-C4)alkyl(optionally substituted with 1 to 3 halogens), -(C2C.)aikyl-O-R3". -C(0)-(C1-C4)alky1. -C(0)0-(C1-C4)alkyi. or 10 -C(0)-N(R20)(R20); R9is -H,-halogen, -CHj (optionally substituted with 1 to 3 halogens), or -O-CHj (optionally substituted with 1 to 3 halogens); R10 is independently at each occurrence -H or -halogen; 15 R11is independently at each occurrence -H, -CHi, or -CH;2CH R20is independently at each occurrence -H or (C1-C3))alkyl(optionally substituted with 1 to 3 halogens); R2! is independently at each occurrence -H, -halogen, or -(C1-C3)alkyl; R22 is independently at each occurrence -H or (C1-C3))alkyl(optionally substituted with 1 20 to 3 halogens); R23 is independently at each occurrence -H, -(C1-C3)alkyl, or -C(0)0-(C1-C4)alkyl; R24is independently at each occurrence -H. -halogen, or -(C1-C3))alkyl{optionally substituted with 1 to 3 halogens); R~' is independently at each occurrence -H.-halogen, or (C1-C3)alkyl; and 25 R4 is independently at each occurrence -H or -CH3 In another embodiment the invention provides a compound structurally represented by formula 1, or a pharmaceutically acceptable salt thereof, wherein R1 is WO 2007/124337 PCT/US2007/066921 , wherin the dashed the point of tachment to the R1 position in formula 1; R2 is -halogen; R is -halogen: 5 R4 is -H or -halogen; R5is 10 wherein the dashed lithe point of attachment to the R5 position in formula I; R6is 0 2007/124337 PCT/US2007/066921 -H, -(C1-C3)alkyl(optiona]ly substituted with 1 to 3 halogens), (C1-C3))alkyl-O-R20, -(C1-C3)alkyl-pyrrolidinyI, phenyl, -HET1, -HET2,-CH3-phenyl, -CH2-HET!, -CHrHET3, -(Cl-C3)alkyl-N(R20XR20),-(C,-C,)alky]-N,(O')(CH3)2l 5 -(C1-C3))alkyl-C(0)N(R'^)(R4,), -CH(C(0)OH)(CH2OR20). -CH(C(O)OH)(CH2N(R20)(R2O)),-(Cl-C3)alkyl-C(O)O-R30, , wherein the dashed line indicates the point of attachment to the position indicated by R'; 10 HET1 is , wherein the dashed line indicates the point of attachment to the 15 position indicated by HET1: HET3 is WO 2007/124337 PCT/US2007/066921 or wherein the dashed line indicates the point of attachment to the position indicated by HET2; R7is 5 -H, -(C1-C3)alkyl(optionally substituted with 1 to 3 halogens), or -(C2-C3)alkyl-O-R20; R8is -H. -OH. -(C1-C4)alkyl(optioiially substituted with 1 to 3 halogens). -(CrCOalkyl-O-R20, -C(O)-(C1-C4)alkyl. -C(O)O-(C1-C4)alkyi, or 10 -C(O)-N(R20)(R2C); R'is -H,-halogen, -CHj (optionally substituted with 1 to 3 halogens), or -O-CH3 (optionally substituted with 1 to 3 halogens); RJ0is independently at each occurrence -H or-halogen; 15 R11 is independently at each occurrence-H, -CH1or-Chh-CH3 R20is independently at each occurrence -H or -(C1-C3))alkyl( optionally substituted with i to 3 halogens); R21 is independently al each occurrence -H, -halogen, or -(C1-C3)alkyl; R22 is independently at each occurrence -H. or -(C1-C3)alkyKoptionally substituted with I 20 to 3 halogens); R25is independently at each occurrence -H, -(C1-C3)alkyl, or -C(0)0-(C1-C3)alkyl; R24 is independently at each occurrence -H, -halogen, or -(C1-C3)alkyl(optionally substituted with I to 3 halogens); R31 is independently at each occurrence -H. -halogen, or -((C1-C3))alkyl; and 25 R41 is independently at each occurrence -H or -CH3 In another embodiment the invention provides a compound structurally represented by formula J. or a pharmaceutically acceptable salt thereof, wherein R'is WO 2007/124337 PCTAJS2007/066921 , wherein the dashed line represents the poim of attachment to the R1 position in formula I; R2 is -halogen; R3 is -halogen; 5 R 4 is -H or -halogen; R5is 10 , wherein the dashed line represents the point of attachment to the K' position in formula I; R"is WO 2007/124337 PCT/US2007/066921 -H, -(C1-C3)alkyl(optionally substituted with I to 3 halogens). -(C1-C3))a!kyl-O-R20, (C1-C3)alkyl-pyrroIidinyl, phenyl, -HET1, -HET2, -CH2-phenyl, -CH2-HET1, -CH2-HET2. -(C1-C3)a\kyl-H(R20)(R20),-(C1-C3)alky\-K(O')(CH3,)2, 5 -(C,-C1}alkyl-C(0)N(R40)(R41),-CH(C(0)0HXCH20R2y), -CH(C(O)OH)(CH3N(R20)(R20)),-(C1-C3))alkyl-C(0)0-R20, wherein the dashed line indicates the point of attachment to the position indicated by R°; 10 HEX1 is therein the dashed line indicates the point of attachment to the 15 position indicated by HET1; HET3 is WO 2007/124337 PCT/US2007/066921 , wherein the dashed line indicates the point of attachment to the position indicated by HEX2; R7is 5 -H, -(C1-C3))alkyI(optionally substituted with 1 to 3 halogens), or -(C1-C3))alky]-0-R20; R8is -H. -OH, -(C1-C3)aikyl(optionally substituted with l to 3 halogens), -(C1-C3))alkyl-0-R2f). -C(0)-(C1-C3)alkyl, -C(0)0-(C1-C3)alkyl. or ™ -C(0)-H(R20)(R20); R9is -H,-haIogen, -CH3 (optionally substituted with 1to3 halogens), or -O-CH3(optionally substituted with J to 3 halogens); R10is independently at each occurrence -H or -halogen; 15 R20is independently at each occurrence -H or (C1-C3)alkyi(optionally substituted with 1 to 3 halogens); R21 is independently at each occurrence -H, -halogen, or -(C1-C3)alkyl; R22 is independently at each occurrence -H or -(C1-C3))allcyi(optionally) substituted with 1 to 3 halogens); 20 R23 is independently at each occurrence -H, -(C1-C3)alkyl,or-C(0)0(C1-C3)alkcyl; R24 is independently at each occurrence -H, -halogen, or -(C1-C3)lkyl(optionally substituted with I to 3 halogens); R31 is independently at each occurrence -H, -halogen, or -(C1-C3)alkyl; and R i's mdependenffy at eacn occurrence ~H or -CH2 25 in another embodiment the invention provides a compund structurally represented by formula I, or a pharmaceutically acceptably said thereof, wherein R1 is wherein the dashed line represents the point ofatlaehment to the R position in formula I; R2 is -halogen; R3s -halogen; R4 is -I I or -halogen; R5 is or . whevcin the dashed line represents the point of attachment tu the R position in Ibrniula I: Rf5 is WO 2007/124337 PCT/US2007/06692I -H, -(C1-C3)aIky](oplionally substituted with I to 3 halogens), -((C1-C3)alkyl-O-R20 , -(C1-C3)a]kyl-pyrro]idinyl, phenyl, -HET1, -HET2,-CH2-phenyI, -CH2-HET\ -CH2-HET2. -(C1-C3)a]kyl-N(R20XR20),-(Ci-C3}alkyl-N,(O-)(CH3)2, 5 -(C1-C3)alkyl-C(0)N(R4i)(R41),-CH(C(OpH)CCH20R20), -CH(C(O)OH)(CH2N(R20)(R20))1-(C,-C3)alky]-C(O)O-R20, , wherein the dashed line indicates the point of attachment to the position indicated by R6; 10 HET1 is , wherein the dashed line indicates the point of attachment to the 15 position indicated by-HET1; HET2 is WO 2007/124337 PCT/US2007/066921 o wherein the dashed tine indicates the point of attachment to the position indicated by HEX2; R7is 5 -H, -(C1-C3)alkyl(oplionally substituted with 1 to 3 halogens), or -(C1-C3)alkyl-O-R20; R8is -H. -OH. -(C1-C3)alkyl(optionaIIy substituted with I to 3. halogens), -(C1-C3)alkyl-O-R20-CO)(C1-C3)alkyl, -(O)0-(C1-C3))alkyl, or 10 -C(O)-N(R20)(RZ0); R9is -H,-halogen, -CH.i (optionally substituted with 1 to 3 halogens), or -O-CH3 (optionally substituted with 1 to 3 halogens); R10 is independently at each occurrence -H or -halogen; 15 R~ is independently at each occuncncc -H or -(C1-C3)alkyl(optionally substituted with 1 to 3 halogens); R is independently at each occurrence -H, -halogen, or -(C1-C3)alkyl; R32 is independently at each occurrence -H or -(C1-C3)alkyl(optionally substituted with I to 3 halogens); 20 R" is independently ai each occurrence -H, -(C1-C3)alkyl, or -C(0)0-(C1-C3)alkyl; R24 is independently at each occurrence -H, -halogen, or -(C1-C3)alkyl( optionally ■substituted with 1 to 3 halogens); R31 is independently at each occurrence -H, -halogen, or -(Ci-Cj)alkyl; and R41 is independently at each occurrence -H or -CH3 25 In another embodiment the invention provides a compound structurally represented by formula 1. or a pharmaceutically acceptable salt thereof, wherein R'is WO 2007/124337 PCT/US2007/066921 , wherein the dashed line represents the point of attachment to the R1 position in formula I; -fluorine, -chlorine, or-bromine; -fluorine, -chlorine, or-bromine; 5 -H or -halogen; 10 0 ; wherein the dashed line represents the point of attachment to the R5 position in formula I; R6is WO 2007/124337 PCT/US2007/06692I ..alkyKoptionally substituted with 1 to 3 halogens), ilkyl-pyrrolidinyl, phenyl, -HET1, -HET2,-CH2-phenyl, -CHj-HET1, -CHi-HET2, 5 wherein the dashed line indicates the point of attachment IO the position indicated by R6: 10 HET1 is - .wherein the dashed line indicates the point of attachment to the 15 position indicated by HET1; HET2 is WO 2007/J24337 PCT/US2007/066921 . wherein the dashed line indicates the point of attachment to the position indicated by MET"; R7is 5 -H, -(C1-C3)alkyifoptionally substituted with I to 3 halogens), or -(C1-C3)alkyJ-0-R20; R8is -H. -((C1-C3)alkyl(optiona]ly substituted with 1 to 3 halogens). 10 R9is -H, -halogen. -CH3 (optionally substituted with 1 to 3 halogens), or -O-CH3 (optionally substituted with 1 to 3 halogens); R'0 is independently at each occurrence -H or -halogen; 15 Rn is independently at each occurrence -H or -CH3; R20is independently at each occurrence -H or -(C|-C_Oalky](optionally substituted with 1 to 3 halogens); R21 is independently at each occurrence -H. -halogen, oi R " is independently at each occurrence-H or -(Ci-Ci)alkyl(optionally substituted with 1 20 to 3 halogens); R2? is independently at each occurrence -H, R2J is independently at each occurrence -H; R3t is independently at each occurrence -H; and R41 is independently at each occurrence -H. 25 In another embodiment the invention provides a compound structurally represented by formula I, or a pharmaceutically acceptable salt thereof, wherein R'is WO 2007/124337 PCT/US2007/066921 , wherein the dashed line represents the point of attachment to the R1 position in formula I; R2 is -fluorine, -chlorine, or -bromine; R3 is -fluorine, -chlorine, or-bromine; 5 R4 is -H; R5is Rr\ wherein the dashed line represents the point of attachment to the R5 10 position in formula 1; R8is -H, -(C1-C3)alkyl(optionally substituted with 1 to 3 halogens), 15 R9is -H,-halogen, -CH3 (optionally substituted with I to 3 halogens), or -O-CH3 (optionally substituted with 1 to 3 halogens); R10 is independently at each occurrence -H or -halogen; R11 is independently at each occurrence -H; 20 R20is independently at each occurrence -H, or -(Ci-C?)alkyl(optionally substituted with 1 to 3 halogens); R3,is independently at each occurrence-H.-halogen, or-(0-C_i)alkyl; R22 is indcpendenily at each occurrence -H or (optionally subsiituled with to 3 halogens); and R2? is independently at each occurrence , wherein the dashed line represents the point of In another embodiment the invention provides a compound structurally represented by formula J, or a pharmaceutic ally acceptable salt thereof, wherein attachment to the R position in formula 1; R2 is -fluorine, -chlorine, or-bromine; R3 is -fluorine, -chlorine., or-bromine, R4is-H; R5is ; wherein the dashed line represents the point of attachment to the R5 position in formula 1; R6is 'optionally substituted with 1 to 3 halogens), WO 2007/124337 PCT/US2007/06692I alkyi-pyrrolidinyl, phenyl, -HET1, _ wherein the dashed line indicates the point of attachment to the position indicated by R6: HET1 is wherein the dashed line indicates the point of attachment to the position indicated by HET ; HET2 is WO 2007/124337 PCT/US2007/066921 or - , wherein the dashed line indicates the point of attachment to the position indicated by HET2; R7is 5 substituted with I to 3 halogens), or R11 is independently at each occurrence -H or -CH3; R20is independently at each occurrence -H or -(C1-C3)alkyl('optionally substiluted with 1 to 3 halogens); 10 R2iis independently at each occurrence -H, -halogen, or(C1-C3))aIkyl; R22 is independently at each occurrence -H or -(C1-C3))alkyl(optionally substituted with 1 to 3 halogens); R23 is independently at each occurrence -H, R24 is independently at each occurrence -H; 15 R31 is independently at each occurrence -H; and R41 is independently at each occurrence -H. Other embodiments of the invention are provided wherein each of the embodiments described herein above is further narrowed as described in the following preferences. Specifically, each of the preferences below is independently combined with 20 each of the embodiments above, and the particular combination provides another embodiment in which the variable indicated in the preference is narrowed according to the preference. Preferably embodiments of the invention are structurally represented by the WO 2007/124337 PCT/US2007/06692I 5 or -O-CH3 (optionally substituted with 1 to 3 halogens). Preferably R2 is -halogen. Preferably R~ is CH3 (optionally substituted with I to 3 halogens). Preferably R2 is -O-CH3 (optionally substituted with I to 3 halogens). Preferably R2 is-chlorine.-fluorine, or-bromine. Preferably R2 is -chlorine. Preferably R1 is -halogen, -CHj (optionally substituted with I 10 to 3 halogens'), or -O-CH? (optionally substituted with 1 to 3 halogens). Preferably R" is -halogen. Preferably R~ is -CHT (optionally substituted with 1 to 3 halogens). Preferably R2 is -O-CH.i (optionally substituted with 1 to 3 halogens). Preferably R" is -chlorine, -fluorine, or -bromine. Preferably R"' is -chlorine. Preferably R~ is -fluorine. Preferably R2 is -chlorine, -fluorine, or -bromine, and R"' is -chlorine, -fluorine, or -bromine. 15 Preferably R2 and R? are chlorine. Preferably R4 is -H. Preferably Rd is -halogen. Preferably R4 is-fluorine or-chlorine. Preferably R5 is R R , WO 2007/124337 PCT/US2007/066921 5 wherein R8 is -H, -(C1-C3)alkyl(optiona][y substituted with 1 to 3 halogens), -(C2-C3)alkyl-0-R2°, 10 (optionally substituted with 1 to 3 halogens), or -O-CH3 (optionally substituted with 1 to 3 halogens); R10 is independently at each occurrence -H or -halogen; R2U is independently at each occurrence -H_. or -(C1-C3))alkyl(optionairy substituted with 1 to 3 halogens); R21 is independently at each occurrence -H. -halogen, or -(C1-C3)alkyl; R22 is independently at WO 2007/124337 PCT/US2007/066921 each occurrence -H or -(C1-C3)alkyl(optionally substituted with 1 to 3 halogens); and R2? is independently at each occurrence -H, -(C|-C3)alkyl, or -C(0)0-(C1-C3))alkyl. Preferably R is wherein R" is -(C1-C3))alkyl(oplionally substituted with 1 to 3 halogens); R9 is -H-halogen, -CH3 5 (optionally substituted with I to 3 halogens; and Rluis independently at each occurrence Preferably Rb is -(Ci-Oalky(optionaliy substituted with 1 to 3 halogens), -(C1-C3)alkyl-10 O-R20 , -(C1-C3)alkyl-pyrrolidinyl, phenyl, -HET1, -HET2,-CH2-phcnyl; -CH2-HET 15 R6 is -(C1-C3)alkyKoptionaily substituted with 1 to 3 halogens), (C1-C3)alky l-O-R20 , -(C,-C3)alkyl-pyrroIidinyl, -(C,-C3)alkyI-N(R20)(R20). KC,-C3)alkyI-]s (0-)(CH3)2, -(C,-C3)alkyl-C(O)N(R'n)fR4'),-CHfC(0)OH)CCH20R20CH(C(0)OH)(CH2N(R20)(R2C)), WO 2007/124337 PCT/US2007/06692I Preferably R7 is -H. Preferably R7 is -(C1-C3)alkylfoptionally substituted with 1 to 3 halogens). Preferably R7 is -(C1-C3)alkyl-O-R20. 5 Preferably R8 is -H. Preferably R8 is -(C1-C3)alkyl(optionally substituted with 1 to 3 halogens), -C(O)-N(RZ0)fRZ0). Preferably R8 is -(C1-C4)alkyl(opiionally substituted with 1 to 3 halogens). Preferably Rs is -(C1-C3))alkyl-0-R20, -C(OMC,-Ca)alkyl -C(O)O-(C1-C3)alkyl. or-C(O)-N(R20XR2(Y Preferably R9 is -(CrC,)aIkyl-0-R20 !0 Preferably R* is -aO)-(C,-C4)aIkyl. Preferably Rs is -C(0)O-(C,-C.>)alkyl. Preferably R8 is -C(0)-HR7(i)(R'20) Preferably R9 is -H. Preferably R9 is -halogen. Preferably R9 is -CHi (optionally substituted with 1 to 3 halogens), or -O-CI-h (optionally substituted with 1 to 3 halogens). Preferably R'°is-H. Preferably R10 is-halogen. Preferably R9is-H and Rl0is-H. 15 Preferably R9is-halogen and Rl0is-halogen. Preferably R"is-H. Preferably R11 is -CH3or -CHrCH3. Preferably R11 is -CH?. Preferably R" is-CH2-CH3. In another embodiment the invention provides a compound structurally represented by formula I. or a pharmaceutical^ acceptable salt thereof, wherein 20 R1 is dashed line represents the point of attachment to the R1 position in formula I; R2 is -chlorine: R? is -chlorine; R4 is -H or -fluorine; Rsis WO 2007/124337 PCT/US2007/066921 k 5 or , therein the dashed line represents the point of attachment to the R5" position in formula 1; R6is 10 WO 2007/124337 PCT/US2007/066921 wherein the dashed line indicates the point of attachment to the position indicated by R6; 5 R9 is -H,-fluorine, or -CF3; R10 is -H or -fluorine; R1' is -H or -CH3 R20is independently at each occurrence -H or -CH3; R3' is independcntiy at each occurrence -H or-fluorine; 10 R22 is independently at each occurrence -H, -CH3. or -CF3, and R" is -H Embodiemnts of the invention include all steroisomeric forms and conformational forms of compounds of formula I and the narrower embodiments described above. A preferred embodiment of the invention arc compounds of the formula 15 l-cyclohexy!-3-{3.5-dichloro-4,-[4-(2-fluoro-ethyl)-pipcra2ine-l-carbonyl]-biphenyl-4-ylmethyl}-pyrrolidin-2-onc and (R)-3-[3,5-dichioro-4'-(4-trifluoromethyI-piperidine-1 -carbonyl)-biphenyl-4-y]mcthyl]-l-(tetrahydro-pyran-4-y])-pyrrolidin-2-one. A further embodiment of the invention are the novel intermediate preparations described herein which are useful for preparing the 1 l-fl-HSDl inhibitors according to formula I and the 20 embodiments described herein. A further embodiment of the invention are the novel intermediate preparations described herein which are useful for preparing 1 -cyclehexy 1-3-{3,5-dichloro-4'-[4-('2-fluoro-ethyI)-piperazine-l-carbonyl]-biphenyl-4-ylmethyl}-pyrrolidin-2-one and (R)-3-[3,5-dichloro-4'-(4-trifluoromethyl-piperidine-l -carbonyl)-biphcnyl-4-y!mcthyl]-l-(tctrahydro-pyran-4-yl)-pyrrolidin-2-onc or a pharmaceutically 25 acceptable salt thereof. Patients with type 2 diabetes often develop "insulin resistance" which results in abnormal glucose homeostasis and hyperglycemia leading to increased morbidity and premature mortality. Abnormal glucose homeostasis is associated with obesity, WO 2007/124337 PCIYUS2 hypertension, and alterations in lipid, lipoprotein, and apolipoprotein metabolism. Type 2 diabetics are at increased risk of developing cardiovascular complications, e.g., atherosclerosis, coronary heart disease, stroke, peripheral vascular disease, hypertension, nephropathy, neuropathy, and retinopathy. Therefore, therapeutic control of glucose 5 homeostasis, lipid metabolism, obesity, and hypertension are important in the management and treatment of diabetes mellitus. Many patients who have insulin resistance but have not developed type 2 diabetes are also at risk of developing "Syndrome X" or "Metabolic syndrome". Metabolic syndrome is characterized by insulin resistance along with abdominal obesity, hyperinsulinemia, high blood pressure, 10 low HDL. high VLDL, hypertension, atherosclerosis, coronary heart disease, and chronic renal failure. These patients are at increased risk of developing the cardiovascular complications listed above whether or not they develop overt diabetes mellitus. Due io their inhibition of M-β-HSDI the present compounds are useful in the treatment of a wide range of conditions and disorders in which inhibition of 11-p-HSDI 15 is beneficial. These disorders and conditions are defined herein as "diabetic disorders" and "metabolic syndrome disorders". One of skill in the an is able to identify "diabetic disorders'" and "metabolic syndrome disorders" by the involvement of 11-p-HSDl activity either in the pathophysiology of the disorder, or in the homeostatic response to the disorder. Thus, the compounds may find use for example to prevent, treat, or 20 alleviate, diseases or conditions or associated symptoms or sequelae, of "Diabetic disorders" and "metabolic syndrome disorders". "Diabetic disorders" and "metabolic syndrome disorders" include, but are not limited io. diabetes, type I diabetes, type 2 diabetes, hyperglycemia, hyper insulinemia, beta-cell rest, improved beta-ceil function by restoring first phase response, prandial 25 hyperglycemia, preventing apoptosis, impaired fasting glucose (IFG), metabolic syndrome, hypoglycemia, hyper-/hypokalemia, normalizing glucagon levels, improved LDL/HDL ratio, reducing snacking, eating disorders, weight loss, polycystic ovarian syndrome (PCOS), obesity as a consequence of diabetes, latent autoimmune diabetes in adults (LADAJ, insulitis, islet transplantation, pediatric diabetes, gestational diabetes. 30 diabetic late complications, micro-zmacroalbuminuria, nephropathy, retinopathy, neuropathy, diabetic foot ulcere, reduced intestinal motility due to glucagon administration, short bowel syndrome, antidiarrheic, increasing gastric secretion. WO 2007/124337 PCT/US2007/066921 decreased blood flow, erectile dysfunction, glaucoma, post surgical stress, ameliorating organ tissue injury caused by reperfusion of blood flow after ischemia, ischemic heart damage, heart insufficiency, congestive heart failure, stroke, myocardial infarction, arrhythmia, premature death, anti-apoptosis, wound healing, impaired glucose tolerance 5 OGT). insulin resistance syndromes, metabolic syndrome, syndrome X. hyperlipidemia, dyslipidcmia. hypertriglyceridemia, hyperlipoproteinemia, hypercholesterolemia, arteriosclerosis including atherosclerosis, glucagonomas, acute pancreatitis, cardiovascular diseases, hypertension, cardiac hypertrophy, gastrointestinal disorders, obesity, diabetes as a consequence of obesity, diabetic dyslipidemia, etc. Thus the 10 present invention also provides a method of treatment of "Diabetic disorders" and "'metabolic syndrome disorders" whiie reducing and or eliminating one or more of the unwanted side effects associated with the current treatments. In addition, the present invention provides a compound of Formula 1, or a pharmaceutical salt thereof, or a pharmaceutical composition which comprises a 1S compound of Formula 1, or a pharmaceutical salt thereof, and a pharmaceutically acceptable carrier, diluent, orexcipient: for use in inhibiting 1 !-p-HSDl activity; for use in inhibiting a 1 l-β-HSDl activity mediated cellular response in a mammal; for use in reducing the glycemic level in a mammal; for use in treating a disease arising from excessive 1 l-β-HSDI activity; for use in treating diabetic and other metabolic syndrome 20 disorders in a mammal; and for use in treating diabetes, metabolic syndrome, obesity, hyperglycemia, atherosclerosis, ischemic heart disease, stroke, neuropathy, and wound healing. Thus, the methods of this invention encompass a prophylactic and therapeutic administration of a compound of Formula 1. The present invention further provides the use of a compound of Formula I, or a 25 pharmaceutical salt thereof for the manufacture of a medicament for inhibiting 11-(5-HSD1 activity; for the manufacture of a medicament for inhibiting 11-β-HSDI activity mediated cellular response in a mammal; for the manufacture of a medicament for reducing the glycemic level in a mammal; for the manufacture of a medicament for treating a disease arising from excessive 11-β-HSD1 activity; for the manufacture of a 30 medicament for treating diabetic and other metabolic syndrome disorders in a mammal; and for the manufacture of a medicament for preventing or treating diabetes, metabolic WO 2007/124337 PCT/US2QG7/066921 syndrome, obesity, hyperglycemia, atherosclerosis, ischemic heart disease, stroke, neuropathy, and improper wound healing. The present invention further provides a method of treating conditions resulting from excessive 1 1-βHSDl activity in a mammal; a method of inhibiting \ 1 -β-HSDl activity in a mammal; a method of inhibiting a 11-β-HSDl activity mediated cellular response in a mammal; a method of reducing the glycemic level in a mammal; a method of treating diabetic and other metabolic syndrome disorders in a mammal; a method of preventing or treating diabetes, metabolic syndrome, obesity, hyperglycemia; atherosclerosis, ischemic heart disease, stroke, neuropathy, and improper wound healing; said methods comprising administering lo a mammal in need of such treatment a 1 1-β-HSDI activity inhibiting amount of a compound of Formula I, or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition which comprises a compound of Formula I, or a pharmaceutical salt thereof, and a pharmaceutically acceptable carrier, diluent, or excipicnt. In addition, the present invention provides a pharmaceutical composition which comprises a compound of Formula I, or a pharmaceutical salt thereof, and a pharmaceutically acceptable carrier, diluent, or excipient; adapted for use in inhibiting 11-β-HSDl activity; adapted for use in inhibiting 11-β-HSDl activity mediated cellular responses; adapted for use in reducing the glycemic level in a mammal; adapted for use in treating diabetic and other metabolic syndrome disorders in a mammal; and adapted for use in preventing or treating diabetes, metabolic syndrome, obesity, hyperglycemia, atherosclerosis, ischemic heart disease, stroke, neuropathy, and wound healing. A pharmaceutical composition of the present invention comprising a compound such as herein described, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier showed surprising and enhanced effects. Therefore, the said composition is synergistic in nature. In a further aspect of the invention the present compounds are administered in combination with one or more further active substances in any suitable ratios. Such further active substances may for example be selected from antidiabetics, antiobesity agents, antihypertensive agents, agents for the treatment of complications resulting from or associated with diabetes and agents for the treatment of complications and disorders resulting from or associated with obesity. The following listing sets out several groups of combinations. It will be understood that each of the agents named may be combined with other agents named to create additional combinations. Thus, in a further embodiment of the invention the present compounds may be administered in combination with one or more antidiabetics. WO 2007/124337 PCT/US2007/066921 Suitable antidiabetic agents include insulin, insulin analogues and derivatives such as those disclosed in EP 792 290 (Novo Nordisk A/S), for example N£B29-tetradecanoyl des (B30) human insulin, EP 214 826 and EP 705 275 (Novo Nordisk A/S), for example AspB2S human insulin, US 5,504,188 (Eli Lilly), for example LysB28 Pro-029 human insulin. 5 . EP 368 187 (Aventis), for example Lantus^. GLP-1 and GUM derivatives such as those disclosed in WO 98/08871 (Novo Nordisk A/S), as well as orally active hypoglycemic agents. The orally aclive hypoglycemic agents preferably comprise imidazolines, sulphonylureas. biguanides, meglitinides, oxadiazolidinediones, thiazolidinediones, 10 insulin sensitizers, insulin secretagogues, such as glimepiride, a-glucosidase inhibitors, agents acting on the ATP-dependent potassium channel of the 3-celis for example potassium channel openers such as those disclosed in WO 97/26265, WO 99/03861 and WO 00/37474 (Novo Nordisk A/S), or mitiglinidc, or a potassium channel blocker, such as BTS-67582, nateglinide, glucagon antagonists such as those disclosed in WO 99/01423 15 and WO 00/39088 (Novo Nordisk A/S and Agouron Pharmaceuticals, Inc.), GLP-1 antagonists, DPP-IV (dipeptidyl pcptidasc-IV) inhibitors, PTPase (protein tyrosine phosphatase) inhibitors, inhibitors of hepatic enzymes involved in stimulation of gluconeogcncsis and/or glycogenosis, glucose uptake modulators, activators of glucokinase (GK) such as those disclosed in WO 00/58293, WO 01/44216, WO 20 01/83465, WO 01/83478. WO 01/85706, WO 01/85707, and WO 02/08209 (Hoffman-La Roche) or those disclosed in WO 03/00262, WO 03/00267 and WO 03/15774 (AstraZeneea), GSK-3 (glycogen synthase kinase-3) inhibitors, compounds modifying the lipid metabolism such as antilipidemic agents such as HMG CoA inhibitors (statins), compounds lowering food intake, PPAR (Peroxisome proliferator-activated receptor) 25 ligands including the PPAR-alpha, PPAR-gamma and PPAR-delta subtypes, and RXR {retinoid X receptor) agonists, such as ALRT-268, LG-1268 or LG-1069. In another embodiment, the present compounds are administered in combination with insulin or an insulin analogue or derivative, such as N*829-tetrad ecanoy! des (B30) human insulin, AspB2S human insulin, LysBZS Pro829 human insulin, Lantus'S', or a mix- 30 preparation comprising one or more of these. WO 2007/124337 PCTAJS2007/066921 In a further embodiment of the invention the present compounds are administered in combination wilh a sulphonylurea such as giibenclamide, glipizide, tolbautamide. chloropamidem, tolazamide, glimepride, glicazide and glyburidc. In another embodiment of ihc invention the present compounds are administered 5 in combination with a biguanide, for example, metformin. In yet another embodiment of the invention the present compounds are administered in combination with a meglitinide, for example, rcpaglinidc or nateglinidc. In still another embodiment of the invention the present compounds are administered in combination with a thiazolidinedione insulin sensitizer, for example, 10 troglitazone, ciglitazone, pioglitazone, rosigiitazone, isaglitazone, darglitazone, englitazone, CS-OU/Cl-1037 orT 174 or the compounds disclosed in WO 97/41097, WO 97/41119. WO 97/41120. WO 00/41121 and WO 98/45292 (Dr. Rcddy's Research Foundation). In still another embodiment of the invention the present compounds may be 15 administered in combination with an insulin sensitizer, for example, such as GI 262570, YM-440, MCC-555. JTT-501, AR-H039242, KRP-297, GW-409544, CRE-I6336, AR-H049020, LY510929, MBX-102, CLX-0940, GW-501516 or the compounds disclosed in WO 99/19313, WO 00750414, WO 00/63191, WO 00/63192, WO 00/63193 such as ragagiitazar (NN 622 or (-)DRF 2725) (Dr. Reddy's Research Foundation) and WO 20 00/23425, WO 00/23415, WO 00/23451, WO 00/23445, WO 00/23417, WO 00/23416, WO 00/63153, WO 63196, WO 00/63209, WO 00/63190 and WO 00/63189 (Novo Nordisk A/S). In a further embodiment of the invention the present compounds are administered in combination with an a-glucosidase inhibitor, for example, voglibose, emiglitate, 25 miglitol or acarbose. In another embodiment of the invention the present compounds are administered in combination with an agent acting on the ATP-dependent potassium channel of the p- cells, for example, tolbutamide, giibenclamide, glipizide, glicazide, BTS-67582 or rcpaglinidc. 30 In yet another embodiment of the invention the present compounds may be administered in combination with nateglinidc WO 2007/124337 PCT/US2007/066921 In still another embodiment of the invention the present compounds are administered in combination with an antilipidemic agent or antihyperlipidemic agent for example cholestyramine, colestipol, clofibrate, gemfibrozil, lovastatin, pravastatin, simvastatin, pravastatin, rosuvastatin, probucol, dextrothyroxine, fenofibrate or 5 atorvaslin. In still another embodiment of the invention the present compounds are administered in combination with compounds lowering food intake. In another embodiment of the invention, the present compounds are administered in combination with more than one of the above-mentioned compounds for example in 10 combination with metformin and a sulphonylurea such as glyburide; a sulphonylurea and acarbose; nateglinide and metformin; repaglinide and metformin, acarbose and metformin; a sulfonylurea, metformin and troglitazone; insulin and a sulfonylurea; insulin and metformin; insulin, metformin and a sulfonylurea; insulin and iroglitazonc; insulin and lovastatin; etc. 15 General terms used in the description of compounds herein described bear their usual meanings. As used herein, the terms "(C1-C3)alky3", "(C1-C4)alkyr or "(C1-C6)alkyr refer to straight-chain or branched-chain saturated aliphatic groups of the indicated number of carbon atoms, such as methyl, ethyl, n-propyl, isopropyl, n-butyl, isoburyl, sec-butyl, t- 20 butyl, and the like. The term "(C1,-C6)alkoxy" represents a C1-C6 alkyl group attached through an oxygen and include moieties such as, for example, methoxy, ethoxy, n-propoxy, isopropoxy, and the like. The term "halogen" refers to fluoro, chloro, bromo. and iodo. The term "(C1-C8) cycloalkyl" refers to a saturated or partially saturated carbocycle ring of from 3 to 8 carbon atoms, typically 3 to 7 carbon atoms. Examples of 25 (C3-C8) cycloalkyl include but are not limited to cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and the like. The term "optionally substituted," or "optional substituents," as used herein, means thai the groups in question are either unsubstituted or substituted with one or more of the substituents specified. When the groups in question are substituted with more than 30 one substiluent, the substituents may be the same or different. Furthermore, when using the terms "independently," "independently are," and "independently selected from" mean that the groups in question may be the same or different. Certain of the herein defined WO 2007/124337 PCT/US2007/066921 terms may occur more lhan once in the structural formulae, and upon such occurrence each term shall be defined independently of the other. It is understood that guinea pigs, dogs, cats, rats, mice, hamsters, and primates, including humans, are examples of patients within the scope of the meaning of the term 5 "patient". Preferred patients include humans. The term "patient" includes livestock animals. Livestock animals are animals raised for food production. Ruminants or "cud-chewing" animals such as cows, bulls, heifers, steers, sheep, buffalo, bison, goats and antelopes are examples of livestock. Other examples of livestock include pigs and avians (poultry) such as chickens, ducks, turkeys and geese. The patient to be treated is 10 preferably a mammal, in particular a human being. The terms 'treatment", "treating" and "treat", as used herein, include their generally accepted meanings, i.e., the management and care of a patient for the purpose of preventing, reducing (he risk in incurring or developing a given condition or disease, prohibiting, restraining, alleviating, ameliorating, slowing, stopping, delaying, or 15 reversing the progression or severity, and holding in check and/or treating existing characteristics, of a disease, disorder, or pathological condition, described herein, including the alleviation or relief of symptoms or complications, or the cure or elimination of the disease, disorder, or condition. The present method includes both medical therapeutic and/or prophylactic treatment, as appropriate. 20 As used herein, the term "therapeutically effective amount" means an amount of compound of the present invention that is capable of alleviating the symptoms of the various pathological conditions herein described. The specific dose of a compound administered according to this invention will, of course, be determined by the particular circumstances surrounding the case including, for example, the compound administered, 25 the route of administration, the state of being of the patient, and the pathological condition being treated. "Composition" means a pharmaceutical composition and is intended to encompass a pharmaceutical product comprising the active ingredicm(s) including compound(s) of Formula 1, and the inert ingrcdicnt(s) that make up the carrier. Accordingly, the 30 pharmaceutical compositions of the present invention encompass any composition made by admixing a compound of the present invention and a pharmaceutical^ acceptable carrier. WO 2007/124337 PCT/US2D07/066921 The term "subsiantially pure" refers to pure crystalline form of a compound comprising greater than about 90% of the desired crystalline form, and preferably, greater than about 95% of the desired crystal form. The term "suitable solvent" refers to any solvent, or mixture of solvents, inert to 5 the ongoing reaction that sufficiently solubilizcs the rcactants to afford a medium within which to effect the desired reaction. The term "unit dosage form" means physically discrete units suitable as unitary dosages for human subjects and other non-human animals, each unit containing a predetermined quantity of active material calculated to produce the desired therapeutic 10 effect, in association with a suitable pharmaceutical carrier. The compounds of the present invention may have one or more chiral centers and may exist in a variety of stereoisomer^ configurations. As a consequence of these chiral centers the compounds of the present invention can occur as racematcs, as individual enantiomers or mixtures of enantiomers, as wel! as diastereomers and mixtures of 15 diastereomers. All such racemales, enantiomers, diastereomers and mixtures are within the scope of the present invention, whether pure, partially purified, orunpurified mixtures. For the examples provided herein, when a molecule which contains a chiral center or centers of known configuration is presented, its stereochemistry is designated in the name and in the structural representation of the molecule. If the stereochemistry is 20 unknown or undefined its stereochemistry is not designated in the name or in the structural representation of the molecule. Embodiments of the invention include the Examples provided herein, and although the Example provided may be of one chiral or conformational form, or a salt thereof, further embodiments of the invention include all other steroisomeric and or conformational forms of the examples described, as well as 25 pharmaceutical ly acceptable salts thereof. These embodiments include any isolated enantiomers. diastereomers, and or conformers of these structures, as well as any mixtures containing more than one form. Furthermore, when a double bond or a fully or partially saturated ring system or more than one center of asymmetry or a bond with restricted rotaiability is present in the 30 molecule diastereomers may be formed. It is intended that any diastereomers, as separated, pure or partially purified diastereomers or mixtures thereof are included within the scope of the invention. Furthermore, some of the compounds of the present invention WO 2007/124337 PCT/US2007/066921 may exist in different tautomeric forms and it is intended that any tautomeric forms which the compounds are able to form are included within the scope of the present invention. The term "enantiomeric enrichment" as used herein refers to the increase in the amount of one enantiomer as compared to the other. A convenient method of expressing 5 the enantiomeric enrichment achieved is the concept of enantiomeric excess, or "ec", which is found using the following equation: ee = E1' - E2 X 100 E1'+E2 wherein E1 is the amount of the first enantiomer and E2 is the amount of the second 10 enantiomer. Thus, if the initial ratio of the two enantiomers is 50:50, such as is present in a racemic mixture, and an enantiomeric enrichment sufficient to produce a final ratio of 70:30 is achieved, the cc with respect to the first enantiomer is 40%. However, if the final ratio is 90:10, the cc with respect to the first enantiomer is 80%. An cc of greater than 90% is preferred, an ee of greater than 95% is most preferred and an ee of greater 15 than 99% is most especially preferred. Enantiomeric enrichment is readily determined by one of ordinary skill in the an using standard techniques and procedures, such as gas or high performance liquid chromatography with a chiral column. Choice of the appropriate chiral column, clucnt and conditions necessary to effect separation of the enantiomeric pair is well within the knowledge of one of ordinary skill in the art. In addition, the 20 .specific stereoisomers and enantiomers of compounds of formula J can be prepared by one of ordinary skill in the art utilizing well known techniques and processes, such as those disclosed by J. Jacques, et al., "Enantiomers. Racemates, and Resolutions", John Wiley and Sons, Inc., 1981, and E.L. Eliel and S.H. Wilen," Stereochemistry of Organic Compounds", (Wiley-lnterscience 1994), and European Patent Application No. EP-A- 25 838448, published April 29, 1998. Examples of resolutions include recrysiallization techniques or chiral chromatography. The compounds of Formula I, can be prepared by one of ordinary skill in the art following a variety of procedures, some of which arc illustrated in the procedures and schemes set forth below. The particular order of steps required 10 produce the 30 compounds of Formula 1 is dependent upon the particular compound to being synthesized, the starting compound, and the relative lability of the substituted moieties. The reagents or starting materials are readily available to one of skill in the art, and to the WO 2007/124337 PCT/US2007/066921 extent not commercially available, are readily synthesized by one of ordinary skill in the art following standard procedures commonly employed in the art, along with the various procedures and schemes set forth below. The following Schemes, Preparations, Examples and Procedures are provided to 5 better elucidate the practice of the present invention and should not be interpreted in any way as to limit the scope of the same. Those skilled in the art will recognize that various modifications may be made while not departing from the spirit and scope of the invention. All publications mentioned in the specification are indicative of the level of those skilled in the art to which this invention pertains. 10 The optimal time for performing the reactions of the Schemes, Preparations, Examples and Procedures can be determined by monitoring the progress of the reaction via conventional chromatographic techniques. Furthermore, it is preferred to conduct the reactions of the invention under an incn atmosphere, such as. for example, argon, nitrogen. Choice of solvent is generally not critical so long as the solvent employed is 15 inert to the ongoing reaction and sufficiently solubilizes the reactants to effect the desired reaction. The compounds are preferably isolated and purified before their use in subsequent reactions. Some compounds may crystallize out of the reaction solution during their formation and then collected by filtration, or the reaction solvent may be removed by extraction, evaporation, or decantation. The intermediates and final products 20 of Formula I may be further purified, if desired by common techniques such as recrystallization or chromatography over solid supports such as silica gel or alumina. The skilled artisan will appreciate that not all substituents are compatible with all reaction conditions. These compounds may be protected or modified at a convenient point in the synthesis by methods well known in the art. 25 The terms and abbreviations used in the instant Schemes, Preparations, Examples and Procedures have their normal meanings unless otherwise designated. For example, as used herein, the following terms have the meanings indicated: "eq" refers to equivalents; "psi" refers to pounds per square inch; "min" refers to minutes; "h" or "hr" refers to hours. "TIX" refers to thin layer chromatography; "HPLC" refers to high performance liquid 30 chromatography; nRr" refers to retention factor; "R," refers to retention time; "5"refers to pan per million down-field from tctramethylsilane; "MS" refers to mass spectrometry. Observed Mass indicates [M+H] unless indicated otherwise. "MS(FD)" refers to field WO 2007/124337 PCT/US2007/066921 desorption mass spectrometry, *'MS(IS)" refers to ion spray mass spectrometry, "Mass spectrum (ion spray)" refers to ion-spray ionization mode. "MS(FIA)" refers to flow injection analysis mass spectrometry, "MS(FAB)" refers to fast atom bombardment mass spectrometry, "MS(EI)" refers to electron impact mass spectrometry, "MS(ES)" refers to 5 electron spray mass spectrometry, "MS (EI)" refers to electron impact mass spectrometry-electrospray ionization, "MS (ES+)'1 refers to mass spectrometry-electrospray ionization, "MS(APCi) refers to atmospheric pressure chemical ionization mass spectrometry, "UV" refers to ultraviolet spectrometry, "]H NMR" refers to proton nuclear magnetic resonance spectrometry. "LC-MS" refers to liquid chromatography-mass spectrometry, "GC/MS" 10 refers to gas chromatography/mass spectrometry. "IR" refers to infra red spectrometry, and the absorption maxima listed for the IR spectra arc only those of interest and not all of the maxima observed. "RT" refers to room temperature. "THF" refers to tctrahydrofuran, "LAH" refers to lithium aluminum hydride, "LDA" refers to lithium diisopropylamidc, "DMSO" refers to dimethylsutfoxide, "DMF" 15 refers to dimethylforamide, "EtOAc" refers to ethyl acetate, "Pd-C" refers to palladium on carbon, "DCM" refers to dichloromethane, "DMAP" refers to dimethylaminopyridine, "LiHMDS" refers to Lithium Hexamethyldisilisane, 'TFA" refers to trifluoroacetic acid, "EDAC" refers to /*/-Ethyl-A'-(3-dimcthylaminopropyl)carbodiimidc hydrochloride, "HOBT" refers to 1-Hydroxy benzotriazole, "Bn-9-BBN" refers to Benzyl -9- 20 borabicyclo(3.3.1]nonane, "Pd(dppf)Cl2" refers to [1,l'-Bis(diphenylphosphino)-ferrocene)dichloropalladium(Il), "EDCI" refers to ALEthyl-/V-(3-dimethylaminopropyl)carbodiimide hydrochloride, "DBU" refers to 1,8-Diazabicyclo[5.4.0]undecene-7, "TBSCI" refers to tert-butyl-dimethyl-silanyloxymethyl chloride, "NBS" refers to "N-Bromosuccimmide, "TsOH" refers to p-toluenesulfomc acid, 25 "DCE" refers to dichbroethane, "DAST" refers to (Diethylamino)sulfur trifluoride, "EA/'H" refers to ethyl acetate/hexanes mixture, "Pd2(dba)j" refers to BJs(dibcnzylideneacetone)palladium1 "BINAP" refers to 2,2'-Bis(diphcnylphospino-l,r-binaphthalene, "NMP" refers to N-Methylpyrrollidine, lTMSCN" refers toTrimethylsilyl cyanide, 'TBAF" refers to Tetrabutylammonium fluoride, "Tf20" refers to 30 trifluoromethanesulfontc anhydride, 'TBSO" refers to tert-butyl-dimethyl-silanyloxy, "OTf * refers to trifluoromethanesulfonate, MeTi(Oi-Pr)i refers to methyltitanium misopropoxide. "BBri" refers to boron tribromide, "PBri" refers to phosphorous WO 2007/124337 PCT/US2007/066921 tribromide, 'Pd(PPh3 )4 refers to tetrakis(triphehyIphoshine)palladium (0), "OAc" refers to acetate, "DME" refers to dimethylethanc, "Et20" refers to diethyl ether, "(Ph3P),iPd" refers to tetr^is(triphenylphoshine)palladium (0), "DMFDMA" refers to N.N-dimethyiforrnamide dimethyl acetal. "EtjN" refers to triethylamine, "tBu" refers to t-5 butyl, "DIPfiA" refers to diisopropylethyl amine, "EDC" refers to -(3- Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, "HOAc" refers to acetic acid, "boc" refers to t-butoxycarbonyl. In a structure, "Ph" refers to phenyl, "Me" refers to methyl, "Et" refers to ethyl, "Bn" refers to benzyl, "MeOH" refers to methanol, "OTf' refers to trifiuoromethanesulfonate, "TIPSO" refers to triisopropylsilanyloxy, 'TBSO" 10 refers to tert-butyl-dimethyl-silanyloxy. The Examples provided herein are illustrative of the invention claimed herein and are not intended to limit the scope of the claimed invention in any way. The preparations and examples arc named using AutoNom 2.2 in ChcmDraw Ultra, or AutoNom 2000 in MDL ISIS/Draw version 2.5 SP1 from MDL Information Systems, Inc., or are provided 15 by Chemical Abstracts Services. A Varian INOVA 400 MHz spectrometer is used to obtain 'H NMR Specta the in the solvent indicated. An Agilent HP1100 instrument equipped with a Mass Spectrometer (Agilent MSD SL) is used to obtain LCMS. A Waters Xterra CI8 (2.1 X 50 mm, 3.5 micron) is used as stationary phase and a standard method is a gradient of 5- 20 100 % acetoiiitrile/methanol (50:50) with 0.2 % ammonium formate over 3.5 minutes then held at \ 00 % B for 0.5 minutes at a column temperature of 50 °C and a flow rate of 1.0 mL/min. Another standard method is a gradient of 5-100 % acetonitrilc/methanol (50:50) with 0.2 % ammonium formate over 7.0 minutes then held at 100 % B for 1.0 minutes, at a column temperature of50°Cand a flow rate ofl.O mL/min. Additional MS 25 analysis via Agilent MSD (loop machine) is standard Flow injection Analysis (FIA), no column is present and flow is 0.5 ml/min of 80% MeOH with 6.5mM Ammonium Acetate for 30secs run time. WO 2007/124337 PCT/US2007/066921 In Scheme A, an optionally substituted phenol (1) is protected (e.g, with TBSC1) 5 to form compound 2, and then compound 2 is converted to the aldehyde (3). Compound 3 is reacted with a compound containing a protecting group (Pg) and leaving group (Lg) to give the ether compound 4. Pg can be -CH3 or -CH3-phenyl and Lg can be mesylate or halo. Preferably, the Lg-Pg compound is ICH3 orBr-CH2-phenyl. The aldehyde is reduced to form the alcohol (5) and then converted to compound 6, a suitable form which WO 2007/124337 PCT/US2007/066921 can be used for 10 react with compound 7. Preferably, compound 5 is halogenated with PBr3 to give the 2-bromo-methyl compound. The lactam (7) is reacted with a base such as LDA, n-Bull, or potassium tert-buloxide (preferably LDA) and then alkylated in a non-protic solvent (preferably THF) with compound 6 to form compound 8. Compound 8 5 is deprotectcd by a suitable method, such as using BBr3 or hydrogen with a catalyst; to form the phenol (9). Compound 9 is convened to (10) by reacting with triflic anhydride (trifluoromethanesulfonic anhydride) and a base, for example pyridine. A coupling reaction is performed on (10) using a phenylboronic acid reagent and a catalyst, such as palladium tetrakisiriphenylphosphine. The phenylboronic acid can be 10 p-carboxyphenyboronic acid or p-carboxymethylphenylboronic acid. If p-carboxyphenylboronic acid is used, compound 12 is formed. However, if p-carboxymethylphcnylboronic acid is used, compound 11 is obtained. Therefore. hydrolysis of the methyl ester is necessary using a suitable base such as potassium hydroxide. The amide (la) can be formed using a coupling procedure as described in 15 coupling procedure 1, 2, 3, or 4 as described in Preparations and Examples. Protection and deproiection of the compounds to form compounds of formula la and others are well known to the skilled artisan and are described in the literature. (For example, sec: Greene and Wuts, Protective Groups in Organic Synthesis. Third Edition, John Wiley and Sons Inc., 1999). 20 Scheme B R2 «. ' ^ 0 In Scheme B, the amide (lb) can be formed from compound 10 by reacting with an optionally substituted 4-cyanophenylboronic acid to form the compound 13. Compound 13 is then oxidized to form the amide Tb. WO 2007/124337 PCT/US20O7/066921 In Scheme C, compound 10 can be converted to Ic in one pot using a catalyst such as palladium, p-chlorocarbonylphenylboronic acid, a base and an amine in a suitable 5 solvent such as dimethoxyethane. Preparation 1 2,6-dichloro-4-hydroxy-benzaldehyde Dissolve 3.5 dichlorophenol (1 kg, 6.13 mol) in 3 L dimethylformamide (DMF) and cool to OX. Add imidazole (918.74 g, 6.75 mol), followed by tcrtbutyldimethyisilyi 10 chloride (J017.13g. 6.75 mol). Warm the mixture to room temperature and stir tor 15 minutes. Four into water (6 L) and extract with ether (4 L). Wash the organic layer with water 2 times, 10% aqueous lithium chloride solution then brine before drying over sodium sulfate. Filter and concentrate under vacuum to obtain tert-butyl-(3,5-dich!oro-phenoxy)-dimethyl-silane (1700 g) as an oil. 15 Dissolve tert-butyl(3,5-dichIoro-phenoxyl dimcthyl-silane (425 g, 1.5 mol) in 4 L dry tetrahydrofuran and cool to -68°C. Slowly add 1.1 equivalents of sec-butyl lithium (103.1 g, 1.61 mol) at-68°C(-1.75hr). After addition is complete stir the reaction at -70°C for 30 min. Add dimethylformamide (168.5 g, 2.3 mol) and stir the reaction at -70°C for I hr. Add 1 M hydrochloric acid in water (3.5 L) and allow the reaction to warm 20 to room temperature. Pour the reaction mixture into ether (5 L), wash with water then brine. Dry over sodium sulfate and concentrate under vacuum to an orange solid. Triturate with cold dichloromethane and filter to recover 250 g (80 %) pale yellow solid. Preparation 2 25 2,6-dichloro-4-methoxy-benzaldehyde Combine 2,6-dichloro-4-hydroxy-bcnzaldehyde(120 g, 628.24 mmol) and potassium carbonate (173.65 g, 1256.5 mmol) in 900 mL dimethylformamide and treat with iodomethane (107 g, 753.9 mmol). Stir the reaction at room temperature for 3 hours. WO 2007/124337 PCT/US2U07/06692I Filter off sol'ds and pour into 6 L of water. Filter solids, wash several times with water, air dry and dissolve in ethyl acetate. Wash with water, followed by brine and then dry over sodium sulfate. Filter and concentrate under vacuum to~100 mL volume, at which point, solids start to crash out. Filter then concentrate down the filtrate to yield a second 5 crop. Wash with hexane, combine all solids and vacuum dry to yield 112.3 g of off-white, solid: 'H NMR (400 MHz, CDC1,) S 10.41 (s, 1H), 6.90 (s, 2H), 3.87 (s, 3H). Preparation 3 2,6-dichloro-4-benzyloxy-benzaldchydc Treat a mixture of 2,6-dichloro-4-hydroxy-benzaldehyde (250 g, 1.3 mol) and 10 potassium carbonate (361.8 g, 2.62 mol) in 2 L dimethylformamide with benzyl bromide (268.64 g. 1.57 mol). Stir the reaction at room temperature for 1 hour. Filter off solids and pour inio i2 L of water. Filter off solid, wash several times with water, air dry and dissolve in ethyl acetate. Dry over magnesium sulfate, filter and concentrate under vacuum to -1 -5 L. Allow to sit overnight then filter. Wash solid with minimal amount of ] 5 hcxanc and vacuum dry. Concentrate the Filtrate under vacuum and triturate with hcxanc to yield a second crop of product which when combined with the first crop equals 245 g white crystals. Repeat to obtain a 3rd crop of 80 g as a light-tan powder (88% overall yield): 1H NMR (400 MHz, DMSO-d6) 6 10.26 (s, 1H), 7.43 (m. 5H), 7.28 (s, 2H), 5.25 (s, 2H). 20 Preparation 4 (2,6-dichloro-4-methoxy-phenyl)-mcthanol Suspend 2.6-dichloro-4-methoxy-benzaldehyde (112 g, 546 mmol) in 1500 mL ethano! and cool in an ice bath to 7°C. Add sodium borohydride (20.67, 546 mmol) portionwise to obtain a solution. Remove the ice bath and stir Sorl hours. Carefully add 25 reaction mixture to saturated ammonium chloride solution (~ 4L) and stir until fully quenched. Extract with dichloromeihane (3 x 1L) and dry the combined organic extracts over sodium sulfate. Filter and concentrate under vacuum to yield 113 g ofa light-tan solid: 1H NMR (400 MHz, CDC13) 8 6.86 (s, 2H), 4.86 (s, 2H), 3.78 (s, 3H), 2.07 (s, 1H). Preparation 5 30 (2,6-dichloro-4-benzyloxy-phenyl)-methanol WO 2007/124337 PCT/US2007/066921 Prepare the title compound essentially as prepared by the method of Preparation 4. NMR (DMSO-d6) 6 7.38 (m, 4H), 7.33 (m, IH), 7.12 (s, 2H), 5.14 (s, 2H), 5.05 (t, 1H), 4.59 (d,2H). Preparation 6 5 2-bromomethyl-l,3-dichloro-5-methoxy-benzene Dissolve (2,6-dichloro^-methoxy-phenyl)-rnethanol (113 g. 545.76 mmol) in 1200 mL dry THF and cool to 0 deg under nitrogen. Add PBr3 (59.1 g, 218.3 mmol) under nitrogen and stir at 0°C for 30 minutes. Pour into saturated aqueous NaHCCh and extract with EtOAc. Dry and concentrate under vacuum to obtain 129.4 g product as an 10 off-white solid. NMR (CDCh) 8 6.88 (s, 2H), 4.73 (s, 2H), 3.79 (s, 3H). Preparation 7 2-bromomcthyl-1,3-dichloro-5-bcnzyloxy-bcnzclic Prepare the title compound essentially as prepared by the method of Preparation in an 89% yield. ES MS (m/z): 347 (M + I). 15 Preparation 8 l-cyclohexyl-3-(2,6-dichloro-4-methoxy-bcnzyl)-pyrrolidin-2-one Dissolve commercially available 1 -cyclohexyl-pyrrolidin-2-onc (88.2 g, 527.9 mmol) in 2500 mL tetrahydrofuran and cool to -78°C. Add 176 mL 2 M LDA and stir for ~5 min. Add 2-bromomethyl-1.3-dichIoro-5-methoxy-benzene (95 g, 351.9 mmol) and 20 allow the reaciion to warm to room temperature. Pour the mixture into saturated ammonium chloride and extract twice with dichloromethane. Dry over sodium sulfate, filter and concentrate under vacuum to obtain a tan solid. Add hexanes and stir rapidly before filtering. Wash the filter cake several times with cold hexane to obtain 86 g (69%) of a light-tan solid: MS (m/z): 356 (M+). 25 Preparation 9 l-cyciohcxyl-3-(2,6-dichloro-4-hydroxy-benzyl)-pyrrolidin-2-one Dissolve l-cyclohcxyI-3-(2,6-dichloro-4-methoxy-benzyl)-pyrrolid\n-2-one (86 g, 241.4 mmol) in 1300 mL dichloromcthanc then cool to 0°C under nitrogen. Slowly add BBr3 (120.9 g, 482.75 mmoL) to the stirring cold solution keeping the internal 30 temperature below 3.5°C. Stir the solution cold for -1 hours, then pour into 4 L of saturated sodium bicarbonate and stir rapidly for~20 minutes. Filter and wash the solid WO 2007/124337 PCT/US2007/066921 with water, then air dry on the funnel. Separate the organic portion of the filtrate and wash with water then brine. Dry over sodium sulfate, filter and concentrate under vacuum. Suspend the resultant tan solid in dichloromethane, filter, wash the solid with dichloromethane and dry to yield 10.5 g of off-white solid. Combine all solids and dry 5 over night in a vacuum oven at 45°C to yield 78.6 g (95%) of a light-tan solid: MS: (m/z) 342 (M+). Preparation 10 Trifluoro-methanesulfonic acid 3,5-dichloro-4-(l-cyclohexyl-2-oxo-pyrrolidin-3- ylmethyl)-phenyl ester 10 Suspend l-cyclohexyl-3-(2,6-dichloro-4-hydroxy-benzyl)-pyrrolidin-2-one 73.5 g, 214.75 mmol) in 1200 mL dichloromethane and cool to 0°C. Add pyridine (169.9 g 2U7.5 mmol) followed by triflic anhydride (90.9 g, 322.12 mmol). Pour mixture into 2 L of water, and separate layers. Wash with saturated CUSOJ to obtain an emulsion. Add solid NaCI to get a solid blue precipitate with the emulsion. 15 Add water to make the mixture fluid and filter off the solid. Rinse the solid with water then with dichloromethane and separate the blue aqueous layer from the red organic layer. Dry over sodium sulfate, filter and concentrate under vacuum to yield a viscous red oil. Purify by silica gel chromatography using 2 kg of silica gel and 25% ethyl acetate /hexane to obtain 78.4 g (77%) of an off-white solid: 'H NMR (400 MHz, DMSO-d6) 6 20 7.8 (s, 2H),3.7(m, IH), 3.3 (m, 2H), 3.15 (m, lH),2.85(m, lH),2.67(m, IH), 1.95 (m. IH), 1.7(m,3H), I.58(m,3H), 1.4- 1.2(m,4H), 1.15(m. IH). Preparation 11 3', 5'-dichloro-4'-(l-cyclohexyl-2-oxo-pyrrolidin-3-ylmcthyl)-biphenyl-4-carboxylic acid methyl ester 25 Dissolve trifluoro-methanesulfonic acid 3,5-dichloro-4-(l-cycIohexyI-2-oxo- pyrrolidin-3-y[mcthyl)-phcnyl ester (5 g, 10.54 mmol) in 50 mL toluene, add aqueous 2 M sodium carbonate and evacuate/purge with nitrogen 3 times. Add p-carboxymethylphenylboronic acid (2.85 g, 15.81 mmol), degas again, then add Pd(PPh?)j (1.22 g, i .05 mmol). Degass/purge one more time then reflux overnight. 30 Separate layers, wash the organic layer with water twice, then wash with brine. Dry over sodium sulfate, filter and concentrate under vacuum to yield a brown foam. Add ethyl WO 2007/124337 PCT/DS2007/066921 acetate to get a tan solid and filter to get 3.8 g product. Concentrate the filtrate to recover 0.4 g more product after purification via silica gel chromatography using 25% ethyl acetate: MS (m/z): 460 (M+). Preparation 12 5 3*, 5'-dichloro-4-(I-cyclohexy]-2-oxo-pyrrolidin-3-ylmethyl)-biphenyI-4-carboxylic acid Place 3', S'-dichloro^'-fl-cyclohexyl-2oxo-pyrrolidinO-ylmethylJ-biphenyl-4-carboxylic acid methyl ester (45 g, 97.74 mmol) in 2 L of cthanol and add KOH (27.42 g, 488.7 mmol). Heat the mixture to 50°C for -4 hours. Filter the dark mixture through Ceiite® while stil! hot. Dilute with ~3 L of water and allow to cool to room temperature. 10 Acidify with IN hydrochloric acid to pH of 2, while rapidly stirring. Filter, rinse with water and vacuum dry to yield 42 g (96%) of a light-tan solid: MS (m/z): 446 (M+). Synthesis of 3'.5'-dichloro-4,-(l-cyclohexyl-2-oxo-pyrrolidin-3-ylmethyl)-3-(luoro-biphenyl-4-carbonitrile. Preparation 13 15 Combine Preparation 10 (trifluoro-methancsulfonic acid 3,5-dichloro-4-(l- cycIohexyl-2-oxo-pyrrolidin-3-ylmcthyl)-phci)yl ester) (1.85 g, 3.90 mmoi). THF (40 mL), 4-cyano-3-fluorophenylboronic acid (0.77 g, 4.68 mmol), sodium carbonate (1.24 g, 11.70 mmol) and water (10 mL) in a round bottom flask. Stir the mixture at 60°C for 5 minutes and then add palladium tetrakistriphcnylphosphine (0.225 g, 0.20 mmol). Warm 20 the mixture at 80°C and stir for 3 hours. Cool and partition between ethyl acetate and aqueous hydrochloric acid (1 N). Separate the organic phase, wash with water then brine. Dry the liquid over sodium sulfate, filter, and concentrate under vacuum. Purify by silica gel (25% ethyl acctatc/hcxanc) to afford 1.07 g (62%) of product: MS (m/z): 445.0 (M+). WO 2007/124337 PCTAJS2007/066921 In Scheme D, the lactam (15) is formed by reading the lactone with cis or trans 4-aminocyclohcxanoI. Then, the nitro-benzoic acid 4-(2-oxo-pyrrolidin-l-yl)-cyclohexyl 5 ester (16) is formed by reacting (15) with 4-nitrobcnzoic acid. In this reaction, if 15 is the cis hydroxy compound, then 16 is the trans nitro-benzoic acid 4-(2-oxo-pyrrolidin-l-y3)-cyclohexyt ester and the 4-hydroxy in compound Id is trans. If 15 is the trans hydroxy compound, then 16 is the cis nitro-benzoic acid 4-(2-oxo-pyrroiidin-l -yl)-cyclohexyl ester and the 4-hydroxy in compound Id is cis. The 4-hydroxy compound (17) is suitably 10 protected (See Greene), preferably with TBSCI, and the protected lactam (18) is alkylated with 6 (see Scheme A) to form the compound 19. The ether (19) is deprotected to form 20 and reacted with triflic anhydride to form 21. The carboxylic acid (22) is formed by a boronic acid coupling reaction. The amide (23) is formed and then deprotected to form the compound of formula Ic. WO 2007/124337 PCT/US2007/066921 Preparation 14 Add trans-4-aminocyclohexanol (230 g, 2.0 mol) to y-butyrolactone (140 mL, 1.82 mol) in a 1L round-bottom flask equipped with large magnetic stirrer, thermometer 5 and condenser/nitrogen bubbler. Heat the mixture at 190°C for 68 hours. Cool to ambient temperature and mix with water (IL). Extract into dichloromethane (10 x 1.5L). Dry the extracts over magnesium sulfate, filter and evaporate to a brown solid. Triturate with diethyl ether to afford 344.7 g (43%) of the title compound: MS(m/z): 184 (M+l). Preparation 15 10 Cis-4-nitrQ-benzoic acid 4-(2-oxo-pyrrolidin- 1-yl)-cyclohexyl ester Dissolve l-(tran.v-4-hydroxy-cyclohexyl}-pyrrolidin-2-one (144 g, 0.79 mol) in dry tetrahydrofuran (5L) and cool to -5°C under nitrogen. Add triphenylphosphtne (3 10 g, 1.185 mol) and 4-nitrobenzoic acid (198 g, 1.185 mol). Add diisopropyl azodicarboxylatc (230 mL, 1.185 mol) drop-wise and stir at room temperature overnight. 15 Add saturated aqueous sodium bicarbonate (1L) and extract into dichloromethane (2 x 2.5L) in a 20L separating funnel. Dry the combined organic layers over magnesium sulfate, filter and concentrate. Purify over silica gel (iso-hexane/ethyl acetate 50-100% then 10% methanol in ethyl acetate) to afford 163 g (62%) of the title compound. Preparation 16 20 cis-\ -(4-hydroxy-cyclohcxyl)-pyrrolidin-2-onc Dissolve m-4-nitro-benzoic acid 4-(2-oxo-pyrrolidin-i-yl)-cyclohexyl ester (87.9 g, 264 mmo!) in methanol (i.35 L) and water (150 mL)and treat with potassium carbonate (109.5 g, 800 mmol). Stir at room temperature overnight to give a white precipitate. Evaporate to dryness. Remove excess water by mixing with ethanol and 25 concentrating to dryness under vacuum. Repeat this procedure. Stir in tetrahydrofuran (1L) for 1 hour then filter. Evaporate the filtrate to an oil and crystallize from diethyl ether (100 mL) to afford 40 g (83%) of the title compound. Preparation 17 cisl-[4-(terr-butyl-dimethyl-silanyloxy)-cyclohexyl]-pyrTo[idin-2-one 30 Dissolve as-1 -(4-hydroxy-cyclohexyl)-pyrrolidin-2-one (40 g, 220 mmol) in dry dichloromethane (1 L). Add imidazole (22.5 g. 330 mmol) followed by ten-butyldimethylsilyi chloride (50 g, 330 mmol). Stir under nitrogen at room temperature WO 2007/124337 PCT/US2007/066921 overnight. Wash with water (250 mL) and saturated aqueous sodium bicarbonate (250 mL). Dry over magnesium sulfate, filter and evaporate to an oil. Pass through a silica gel pad with iso-hexanc/cthyl acetate (0-50%) to afford 51 g (79%) the title compound as a clear, pale-yellow oil: MS(m/z): 298 (M+l). 5 Preparation 18 3-(4-bcnzyloxy-2,6-dichloro-benzyl)-c/s-l-[4-(tert-butyl-dimethyl-si]anyloxy)-cyclohexyI]-pyrroIidin-2-one Prepare the title compound essentially by the method of Preparation 8(1-cyclohexyI-3-(2,6-dichIoro-4-methoxy-benzyl)-pyrrolidin-2-one) in a 53% yield starling 10 from 2-bromomethyl-l ,3-dichloro-5-benzyloxy-benzene and C/A-1 [4-(tert-butyl-dimcthyl-silanyloxy)-cyc1ohexyl]-pyrrolidin-2-one. Preparation 19 Cis-I-[4-(tcn-butyl-dimcthyl-silany]oxy)-cyclohcxyl]-3-(2,6-dichloro-4-hydroxy-benzyl)- pyrrol id in-2-one 15 Add a solution of 3-(4-benzyloxy-2,6-dichloro-benzyl)-c7.s-l-[4-(tert-butyI- dimethyl-silanyloxy)-cycIohexyl]-pynrolidin-2-one(8.5 g 15.1 mmol) in 25 mL tctrahydrofuran to 0.5 g Pearlman's catalyst and hydrogenate the resulting mixture under a balloon of hydrogen gas 2 hr. Filter through Cclitc© and concentrate to get a solid. Purify by silica gel chromatography using hexanes/ ethyl acetate to recover4.4 g (61%) 20 of product. Preparation 20 Trifluoro-methanesulfonic acid 4-{cis-l-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]- 2-oxo-pyrrolidin-3-ylmethyI}-3,5-dichloro-phenyl ester Prepare the title compound essentially by the method of Preparation 10 in an 88% 25 yield starting from m-l-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-3-(2,6-dichloro-4-hydroxy-benzyl)-pyrrolidin-2-one. Preparation 21 4'-{cis-l-[4-(tert-butyl-dimcthyl-silanyloxy)-cyclohexyl]-2-oxo-pyrrolidin-3-yImethyl}- 3',5'-dichloro-biphcnyl-4-carboxylic acid 30 Prepare the title compound essentially by the method of making Preparation 11 in an 88% yield starting from trifluoro-methanesulfonic acid 4-{cis-l-[4-(tert-butyl- WO 2007/124337 PCT/US2007/06692J dimethyl-silanyloxy)-cyclohcxyl]-2-oxo-pyrrolidin-3-ylmethyl)-3,5-dichloro-phenyI ester and 4-carboxyphenyl boronic acid. Table 1: The Preparations in Table I may be prepared essentially as described in Example 5 3 except for the amine is replaced with the amine as indicated. WO 2007/124337 PCT/US2007W66921 * 'H NMR (400 MHz, DMSO-d6> 5 7.8-7.75 (m. 4H), 7.45 (d, 2H), 3.85 (s, 4H), 3.6-3.55 (m, 2H), 3.4-3.2 (m. 5H), 3.15 (q, 1H), 2.9-2.8 (m, IH), 2.75-2.65 (m, 1H), 1.95-1.85 (m.lH), 1.75-1.5 (m, 10H), 1.45- 1.15 (m,4H), LUl.0(m, IH). Scheme E 10 Scheme E shows the stereo selective synthesis to form the intermediate compound 26. Compound 24 is formed by acylating commercially available (R)-4-benzyl-oxazoIidin-2-one with 4-pentenoyl chloride. It is then alkylated with an optionally substituted compound 6 (sec Scheme A) to give compound of 25. Compound 25 is oxidized to form the aldehyde intermediate compound 26 using ozone and triphenylphosphine or osmium tetroxide and an oxidant such as sodium metaperiodate. WO 2007/124337 PCT/US2007/066921 Scheme F In Scheme F, the intermediate (27) is converted to the lactam compound 28 which 5 is in the "R" configuration. The alcohol on the cyclohcxyl is protected (see Greene) with a suitable protecting group, for example by reacting with TBSCl or WO 2007/124337 PCT/US2007/066921 triisopropylsilyhrifluoromethane sulfonate to form compound 29. A deprotection is performed to give compound 30 which is then trfiiated to form compound 3 ]. The carboxylic ester compound (32) is formed and converted to the acid (33) via a hydrolysis. Optionally, compound 31 can be converted to the carboxylic acid 33 directly by using A-carboxyphenylboronic acid. The amide (34) is formed by reacting the acid with an appropriated amino containing compound and then deprotected to form the compound of formula Id. Scheme G 10 WO 2007/124337 PCT/US2007/066921 In Scheme G, the aldehyde (27) is converted into the lactam (35) with the stereo designation of "R." The benzyl is removed to form 36 and then 36 is inflated to form 37. The carboxylic acid ester (38) is formed and then the acid is formed. The amide (Ic) is formed by reacting the appropriate amine containing compound with the acid (39). Scheme H R [f O In Scheme H, the tetrahydropyran lactam (40) is formed by reacting the aldehyde of 27 with 4-aminotetrahydropyran. The reaction results in compound 40 to be in the "Rv stereo configuration. The benzyl group on 40 is removed to form the alcohol of 41. 10 Compound 41 is inflated to form 42, and then the carboxylic acid ester (43) is formed by reacting with 4-methoxycarbonylphenylboronic acid. The acid (44) is formed and then the appropriated amine containing compound is reacted with the acid (44) to form the amide of compound If. WO 2007/124337 PCTVUS2007/066921 Scheme 1 10 In Scheme I, the mcthoxy compound (46) is formed by reacting the hydroxy compound (45) with iodomethane. Then, compound 46 is deprotected to form compound 47 which is triflated to form compound 48. The carboxylic acid esier (49) is formed by reacting with 4-meihoxycarboiiylphenylboronic acid. The acid (50) is formed and then the appropriate amine containing compound is reacted with the acid (50) to form the compound Ig. Preparation 25 (R)-4-benzyl-3-pent-4-enoyl-oxazolidin-2-one Flush with nitrogen a 12 L 3-neck round bottom flask equipped with a mechanical stirrer, internal temperature probe/N2 inlet, and 1L addition funnel for 20 min and then add (R)-4-bcnzyl-2-oxazoiidinone(250 g, 1.41 mol). Dilute with tctrahydrofuran (THF) (1.8 L) and cool in a dry ice/acetone bam until the internal temperature is -74°C. Transfer WO 2007/124337 PCT/US2007/066921 a 1.6M hexanes solution of n-butyllithium (970 mL, 1.552 mol) to the addition funnel via cannula, and add to the oxazolidinone solution at a rate such that the internal temperature does not reach above -65°C. After the addition is complete, allow the reaction to stir in the cooling bath 30min. Transfer 4-pentenoyl chloride (175 mL, 1.585 mol) to the 5 addition funnel and add dropwise to the anion solution over a 25 min period. Stir the reaction for 45 min in the cooling bath. Remove the cooling bath and stir the reaction 18 hr as it slowly reaches room temperature. Dilute the mixture with IN aqueous hydrochloric acid (1.5L) and diethyl ether (1 L). Separate the layers and wash the organic phase with water (2X 1L) then brine (1 L). Extract the combined aqueous washes with 10 ether(l L). Dry the combined organic phases over anhydrous magnesium sulfate, filter, and concentrate to 390 g of a light tan oil. Purify this material by silica gel chromatography using hexanes:ethy] acetate to obtain 345 g (94.5%) of a clear. yellow oil. Preparation 26 (5 (R)-4-benzyl-3-[244-benzyloxy-2,6^dichloro-benzyl)-pent-4-cnoyl]-oxazolidin-2-one Stir a mixture of (R)-4-bcnzyl-3-pcnt-4-enoyl-oxazolidin-2-one (345 g, 1.33 mol) and THP (1.8 L) in a 12 L 3-neck round bottom flask, with internal temperature probc/nitrogen inlet and addition funnel, under a nitrogen atmosphere and cool to -75°C. Transfer 1 M LiHMDS (1.6 L) to the addition funnel and add at a rate such that the 20 internal temperature does not reach above -60°C. After the addition is complete, allow the reaction to stir at -25°C for 30 min then cool to about -60°C. At this point add solid 2-bromomcthyl-l,3-dichloro-5-benzyloxy-bcnzeneportionwiscover5 min. After the addition is complete, transfer the reaction vessel to a -10°C acetone bath and maintain the in\ema\ reaction temperature below 1G°C for 1 hr. Coo\ Vhe rmixture\o 0°C \heti quench 25 with 2 L aqueous IN hydrochloric acid. Transfer the mixture to a 22 L separatory funnel and dilute with 2.5 L water and 2 L ether. Separate the layers and extract the aqueous layer with ether. Dry the combined organic phase over anhydrous magnesium sulfate, filter and concentrate to 800 g of a thick oil. Purify by silica gel chromatography using hexanes:ethyl acetate to obtain 597 g, (86 %) of a colorless oil. WO 2007/124337 PCT/US2n07/066921 Preparation 27 4-(4-(R)-benzyl-2-oxo-oxazolidin-3-yl)-3-(4-benzyloxy-2,6-dichloro-ben2yl)-4-oxo- butyraldehyde Cool a mixture of (R)-4-benzyl-3-[2-(4-benzyloxy-2,6-dichloro-benzyl)-pent-4-5 enoyl]-oxazolidin-2-one (100 g, 190.68 mmol) and dichloromethane (800 ml) to -74°C. Bubble ozone, produced via the A-113 ozone generator at a rate of 75%, through the reaction via carrier air at a rate of 5 CFM until the solution takes on a blue color (approx 3 hr). Add triphenylphosphine (60 g, 228.8 mmol) as a solution in 200 mL dichloromethane and allow the reaction to stir while reaching room temperature over 10 night. Concentrate the solution under vacuum and purify by silica gel chromatography using a gradient of 20-50% ethyl acetate in hexanes to obtain 82.1 g (82 %) of the product as a white foam: MS (m/z): 526 (M+). Alternate procedure for making 4-(4-(R)-benzyl-2-oxo-oxazolidin-3-yl)-3-(4-benzyloxy-2,6-dichlgro-benzyl)-4-oxo-butyraldehyde: 15 Treat a mixture of (R)-4-benzyl-3-[2-(4-bcnzyloxy-2;6-dichloro-bcnzyl)-pent-4- cnoyl]-oxazolidin-2-onc (0.96 g, 1.8 mmol). THF (21 mL) and waier (7 mL) with 2.5% osmium tetroxide in t-butanol (46 mg, 0.18 mmol). Add sodium periodate (1.17 g, 5.5 mmol) and stir the reaction 4 hr at room temperature. Quench the reaction with water and extract with ethyl acetate. Wash the organic phase with aqueous IN sodium thiosulfate 20 then brine. Dry the organic layer over magnesium sulfate, filter, and concentrate under vacuum. Purify the crude material by silica gel chromatography using hexanes: ethyl acetate to elute the pure product. Concentrate the fractions containing product under vacuum to afford 0.46 g (48%) of desired product. MS (m/z): 526 (M+). Preparation 28 25 3-(R)-3-(4-ben2yloxy-2,6-dichIoro-benzyl)-m-l-(4-hydroxy-cyclohexyI)-pyrrolidin-2- one Stir a mixture of dlcbloroethane (600 mL), magnesium sulfate (100 g), diisopropylethylamine (20.26 g, 156.7 mmol), cis-4-amino-cyclohexanol (1 lg, 95.5 mmol), and4-(4-(R)-benzyl-2-oxo-oxazo!idin-3-yl)-3-(4-benzyloxy-2,6-dichloro-benzyl)-30 4-oxo-butyraIdehyde (32 g. 62.69 mmol) a( room temperature in a nitrogen purged flask for 24 hn under a nitrogen bubbler. Add sodium triacetoxyborohydride (80 g) and stir 1 WO 2U07/124337 PCT/US2007/OG6921 hr. Add 50 mL diisopropylethylamine and 20 g sodium triacetoxyborohydride before heating the mixture to 50°C on rotavap while rotating at ambient pressure. Afterl hr heat the mixture to an interna! temperature of 70°C. Cool the reaction to 35°C, add water and filter. Dilute the filtrate with ether and separate the layers. Wash the organic layer with 5 1: i water:brine, then extract the combined aqueous layers with ether. Dry the combined organic phases over sodium sulfate, and concentrate to about 48 g of a an oil. Purify via silica column using a stepwise gradient of 9:1, then 9:5 ethyl acetate:methanol to obtain 22 g (78%) of the product as a white foam: MS (m/z): 448 (M+). Preparation 29 10 3-(R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4-hydroxy-cycIohexyl)- pyrrolidin-2-one Prepare the title compound essentially by the method of Preparation 28 in an 54% yield starting from jrans-aminocyclohexanol and 4-(4-(R)-benzyl-2-oxo-oxazolidin-3-yl)-3-(4-benzyloxy-2,6-dichloro-benzyl)-4-oxo-butyraldehyde: MS (m/z): 448 (M+). 15 Preparation 30 3-(R)-3-(4-benzyloxy-2.6-dichloro-benzyI)-I-cis-(4-triisopropylsilanyloxy-cyclohexylV pyrrolidin-2-one Stir a mixture of 3-(R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-cj5'-l-(4-hydroxy-cyclohexyl)-pyrrolidin-2-one (20.3 g. 45.27 mmo!) and 30 mL dichloromcthane in an 20 ice/acetone bath. Add pyridine (4.3 g, 54.33 mmol) followed by triisopropylsilyltrifluoromethane sulfonate (15.3, 49.8 mmol). Remove the cold bath and stir the reaction 30 min. Pour into 500 mL water, separate the layers and extract the aqueous phase with 50 mL dichloromcthane. Dry the combined organic phase over sodium sulfate, filter, and concentrate. Purify the residue by silica gel chromatography by 25 eluting with 9:1 to 7:3 hexanes:ethyl acetate to give 24.3 g (88.8%) of the product as a pale ivory foam: MS (m/z): 604 (M+). Preparation 31 3-{R)-3-(4-Bcnzy!oxy-2,6-dichloro-benzyl)-l-(4-triisopropylsilanyloxy- cyclohexyl)-pyrrolidin-2-one WO 2007/124337 PCT/US2007/066921 Prepare the title compound essentially by the method of Preparation 31 in an 99% yield starting from 3-(R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-tran4,-l-(4-hydroxy-cyclohexyl)-pyrrolid'n-2-onc: MS (m/z): 604 fM+). Preparation 32 5 (R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-c/s-I-[4-(tert-butyl-dimcthyl-silanyloxy)- cyclohexyl]-pyrrolidin-2-one Combine 10.8 g (R)-3-(4-bcnzyIoxy-2,6-dichloro-benzyl)-c/i-l-(4-hydroxy-cvclohexyl)-pyrrolidin-2-one, 5.4 g tert-butyldimethylsilylchloride, and 2.7 g imidazole in 50 mL dry dimethylformamide and stir at ambient temperature over night. Pour into 10 300 mL brine an|d extract twice with 200 mL diethyl ether. Wash the combined extracts with brine, dry over magnesium sulfate and concentrate to dryness under vacuum. Purify by silica gel chromatography using 10-15% ethyl acetate in hexancs to recover 11.5 g of the product an oil. Preparation 33 15 (R)-3_(2,6-dichloro-4-hydroxy-benzyl)--cis-l-(4 triisopropylsilanyloxy-cyclohcxyl)- pyrrolidin-2-one Add a solution of 3-(R)-3-(4-benzyIoxy-2,6-dichIoro-benzyl)-l-c/s-(4-triisopropylsilanyloxy-cyclohexyl)-pyn'olidin-2-one (24.3 g, 40.18 mmol) in 250 mL ethyl acetate to 5 g Pearlman's catalyst and hydrogenate the resulting mixture under a 20 balloon of Hydrogen gas 2 hr. Filter through Celite® and concentrate to 20.7 g (100%) of a foam: MS (m/z): 515 (M+l). Preparation 34 (.R.)-3-4-benzyol-2,6-dichloro-benzyl)-trans-1-(4-(tert-butyl-dimethyl silnyloxy) cyclohexyl]-pyrrolidin-2-one 25 Prepare the title compound essentially by the method of Preparation 32 in an starting from 3-(R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-rmns-l-(4-hydroxy-cyclohcxyl)-pyrrodin-2-one (Preparation 29) and tcrt-butyldimethylsilyl chloride. Preparation 35 (R)-/ran5'-l-[4-(tert-Butyl-dimethyl-silanyloxy)-cyclohexyl]-3-f2I6-dichloro-4-hydroxy- 30 benzyl )-pyrro!idin-2-one WO 2007/12-1337 PCT/US2007/066921 Prepare the title compound essentially by the method of Preparation 34 starting from(R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-/ranA-l-[4-(tert-butyl-dimethyl-silanyloxy}-cyclohexyl]-pyrrolidin-2-one. Preparation 36 5 (R)-Cis-l-[4-Ctert-ButyI-dimethyi-silanyloxy)-cyclohexyI]-3-(2,6-dichloro-4-hydroxy- benzyl)-pyrrolidin-2-onc prepare the title compound essentially by the method of Preparation 34 starting from(R)-344-benzyloxy-2,6dichloro-benzyl)-cis/.v-l-[4-(tert-butyI-dirnethy1-silany1oxyV cyclohexy]J-pyrrolidin-2-one. 10 Preparation 37 (R)-trans5-l-[4-(triisopropyl-silanyloxy)-cyclohcxyl]-3-(2.6-dichIoro-4-hydroxy-bcn2yl)- pyrrolidin-2-onc Prepare the title compound essentially by the mctnod of Preparation 35 in a 91% yield starting from (R)-3-(44>enzyloxy'2,6-dichloro-benzy])-'transf-l-[4-(triisopropyl-15 silanyloxy)-cyclohexyl]-pyrrolidin-2-one: MS (m/z): 5!4 f.M+). Preparation 38 Trifiuoro-methanesulfonic acid 3,5-dichloro-4-[(R}-2-oxo-di-l-(4-triisopropylsilanyloxy-cyclohexylVpyrro!idin-3'ylmethy']-phenyl ester Stir a solution of (R)-3-(2,6-dichloro-4-hydroxy-bcnzyl)-c/.s-1-(4 20 triisopropylsilanyloxy-cyclohcxyl)-pyrrolidin-2-one (20.7 g. 40.22 mmol) in 150 mL pyridine in an ice/water bath 10 min, then add triflic anhydride (12.48 g, 44.25 mmol) over 5 min via syringe. Remove the cooling bath and stir the reaction 18 hr at room temp. Cool to 0°C in an icc/brinc bath and add 500 mL waicr slowly so that internal temp does not rise above 5°C. Transfer to separatory funnel, dilute with 300 mL ether, separate 25 the layers and then extract the aqueous layer with 150 mb ether. Wash the combined organic layer with water, dry over sodium sulfate, filter and concentrate under vacuum. Purify via silica gel chromatography by eluting with 40-50% ethyl acctate/hexanes to recover 25 g (96 %) of the product: MS (m/z); 646 (M+), Preparation 39 30 Trifiuoro-methanesulfonic acid 3,5-dichloro-4-[(R)-2-oxo-transl-(4- triisopropylsilanyloxy-cyclohexyl)-pyrrolidin-3-ylmethy]j-phenyl ester WO 2007/124337 PCT/US2007/06692I Prepare the title compound essentially by the method of Preparation 38 starting from (R)-/ran5-l-[4-(triisopropyl-silanyloxy)-cyclohexyl]-3-(2,6-dichloro-4-hydroxy-benzyl)-pyrrolidin-2-one. Preparation 40 5 Trifhjoro-methanesulfonic acid 4-{(R)-c/.?-l-[4-(tert-butyl-dimethyl-silanyloxy)- cyclohexyl]-2-oxo-pyrrolidin-3-ylmethyl}-3,5-dichloro-phenyl ester Prepare the title compound essentially by the method of Preparation 38 starting from(R)-c/.?-l-[4-(tert-butyl-dimethyl-RUanyIoxy)-cyclohexyl]-3-(2,6-dichloro-4' hydroxy-benzyl)-pyrrolidin-2-one. 10 Preparation 41 Trifluoro-methanesulfonic acid 4-{(R)-/rarts-l-[4-(tert-butyl-dimcthyl-silanyloxy)-cyclohcxylj-2-oxo-pyrrolidin-3-ylmcthyI}-3,5-dichloro-phenyl ester Stira solution of (R)-3-(2,6-dichloro-4-hydroxy-benzyl)-/ra/tf-]-(4 ten-butyIdimethylsilanyloxy-cyclohexyl)-pyrrolidin-2-one (4.2 g, 8.9 mmol) and N-phenyi-1.5 bis-uifluoromcthancsulfonimidc (3.2 g, 8.9 mmol) in 50 mL dichloro methane. Add tricthylamine (1.8 g, 17.8 mmol) and stir the reaction 18 hrat room temp. Wash the mixture with a solution of 5% citric acid in water, dry over magnesium sulfate, filter and concentrate under vacuum. Purify via silica gel chromatography by eluting with hex-30% ethyl acetate to recover 4.3 g (79 %) of the product. 20 Preparation 42 4'-{(R)-/trans-l-[4-(tcrt-Butyl-dimethyl-silanyloxy)-cyciohcxyl]-2-oxo-pyrTotidin-3-ylmethyl}-3',5'-dichloro-biphcnyl-4-carboxylic acid Prepare the title compound essentially by the method of Preparation 44 in a starting from trifluoro-methanesulfonic acid 4-{(R)trans-l-[4-{tert-butyl-dinicthyl-25 silanyloxy)-cyclohexyl]-2-oxo-pyrrolidin-3-ylmethyl}-3,5-dichloro-phenyl ester and 4-carboxyphenylboronic acid. Preparation 43 3',5'-dichloro-4'-[(R)-2-oxo-ds-l-(4-triisopropylsilanyIoxy-cyclohexyl)-pyiTolidin-3- ylmethyl]-biphenyl-4-carboxylic acid methyl ester 30 Bubble nitrogen through a mixture of trifluoro-methanesulfonic acid 3,5-dichloro- 4-[(R)-2-oxocis-l-(4-triisopropylsiianyloxy-cyclohexyl)-pyrrolidin-3-ylmethyl]-phenyl WO 2007/124337 PCT/US2007/06692I ester (12.2 g, 18.87 mmol), 4-methoxycarbonylphenylboronic acid (4.1 g, 22.64 mmol), sodium carbonate (6 g, 56.6 mmol), 50 mL water, and 150 mL letrahydrofuran for 30 min at room temperature. Add tctrakis(triphenylphosphine)palladium (1.7 g, 1.47 mmol) by weighing into a nitrogen Filled vial and transferring the material as a dry solid to the 5 reaction flask. Sparge an additional 5 min, then heat at 80°C 1 hr. Dilute with 50 mL each of water and ethyi acetate, separate layers and extract the aqueous layer with 25 mL ethyl acetate. After combining the organic layers, wash with 50 mL brine, dry over magnesium sulfate and concentrate under vacuum. Purify on silica by eluting with 10-30% ethyl acetate in hexancs to give 11.1 g (93 %) of product as an ivory foam: MS 10 (m/z): 632 (M+). Preparation 44 3',5'-dichloro-4'-[(R)-2-oxo-trans-I-(4-triisopropyisi!anyioxy-cyclohexyl)-pyrrofidin-3-ylmethy!]-biphenyl-4-carboxylic acid methyl ester Prepare the title compound essentially by the method of Preparation 43 in an 80% 15 yield starting from trifluoro-methanesulfonic acid 3,5-dichloro-4-[(R)-2-oxo-trans-l-(4-triisopropylsilanyloxy-cyclohexyl)-pyrrolidin-3-ylmelhyl]-phcnyl ester: MS (m/z): 632 (M-). Preparation 45 3',5'-dichloro-4'-[(R)-2-oxo-cis-1-(4-triisopropylsilanyloxy cycIohexyl)-pyrrolidin-3- 20 ylmethyl]-bipheny]-4-carboxylic acid Stir a mixture of 3,,5'-dichloro-4'-[(R)-2-oxo-cis-l-(4-triisopropylsilanyloxy-cyclohexyl)'pyrrolidin-3-ylmethy!]-biphcnyl-4-carboxylic acid methyl ester (35.6 g, 56.26 mmol), 150 mL THF and 100 mL methanol under nitrogen in an ice/water bath. Add a solution of lithium hydroxide (4.04 g, 168.79 mmol) in 100 mL water. Stir the 25 mixture 4 hr at RT. Cool the solution to about 1 °C in an ice/acetone bath, dilute with 500 mL water, then adjust the pH to about 2-3 with 0.5 M aqueous hydrochloric acid. Extract with ethyl acetate (3 X 150 mL), wash with 100 mL each, water and brine then dry over magnesium sulfate. Filter, and concentrate to 34.6 g (99%) of a foam. Preparation 46 30 3',5'-dichloro-4'-[(R)-2-oxo-/trans-l-(4-triisopropylsilanyloxy cyclohexyl)-pyrrolidin-3- ylmethyl]-biphenyl-4-carboxylic acid WO 2007/124337 PCTYUS2007/066921 Prepare the title compound essentially by the method of Preparation 42 in a 74% yield starting from 3',5'-dichloro-4'-{(R)-2-oxo-rmn5-l-(4-triisopropylsilanyloxy- cyclohexyl)-pyrrolidin-3-ylmethyl]-biphenyl-4-carboxylic acid methyl ester and sodium hydroxide: MS(m/z): 617 (M-H). 5 Preparation 47 4'-J{R)-iri5-l-I4-(ten-Butyl-dimethyl-si!anyloxy)-cyclohexyl]-2-oxo-pyrrolidin-3-ylmethy]}-3',5'-dich]oro-biphenyl-4-carboxylic acid Treat a solution of trifluoro-methanesulfonic acid 4- {(R)-cis- 1 -[4-(tert-buty 1-dimethyl-silanyloxy)-cyclohexyl]-2-oxo-pyrro!idin-3-ylmethyl}-3,5-dichloro-phenyl ester 10 (3 g, 4.96 mmol) in 90 mL dimethoxyeihane with inphenylphosphine (525 mg, 2 mmol). Degas by placing under vacuum and replacing atmosphere with nitrogen several times. Add Pd(OAc)2 (150 mg7 0.67 mmol), 4-phcnylboronic acid (0.82 g. 4.96 mmol), 15 mL methanol and then 12 mL 2 N sodium carbonate. Reflux for 2 hrs. Concentrate under vacuum and dilute the residue with 100 mL 5% aqueous citric acid and 100 mL ethyl 15 acetate. Separate the layers, dry the organic layer over magnesium sulfate and concentrate under vacuum. Purify by silica gel chromatography using 70% (hexanes/ethyl acetate 90/10) in chloroform to recover 2.62 g solid. Preparation 48 (R)-3-{3,5-dichloro-4'-[4-(2-fluoro-cthyl)-pipcra2inc-l-carbonyl]-biphcnyI-4-ylmethyl}- 20 c/s-l-(4-triisopropylsilanyloxy-cyclohexyl)-pyrrolidin-2-one Treat a mixture of 3',5'-dichloro-4'-E(R)-2-oxo-m-l-(4-triisopropylsilany!oxy-cyclohexyl)-pyrrolidin-3-ylmethyl]-biphenyl-4-carboxylic acid (4 g, 5.46 mmol), l-{2-fluoro-ethyl)-piperazine (2.97 g, 12.12 mmol) and diisopropylethylamine(3.13 g, 24.24 mmol) inl25 mL dichloromethane with l-(3-dimethylaminopropyl)-3-ethyIcarbodiimide 25 hydrochloride (3.1 g, 16.16 mmol) and stir at room temperature overnight. Dilutewith 150 mL saturated sodium bicarbonate and separate layers. Wash the organic layer with 150 mL water then 100 mL brine. Extract me combined aqueous layers with 100 mL dichloromethane and combine with original organic layer. Dry over sodium sulfate, filter, concentrate, and purify via silica chromatography to give 4 g (67%) product as a 30 foam: MS (m/z): 732 (M+). WO 2007/124337 PCT/US2007/06692] Preparation 49 (Racemic)-cis-l-[4.(tert-Butyl-dimethyl-silanyloxy)cyclohexyl]-3-[3,5-dichloro-4'-(thiomorpholine-4-carbonyI)-biphcnyl-4-ylmcthyl]-pyrrolidin-2-one The title compound may be prepared essentially as described in Preparation 8a 5 except for using 4'- {cis-l-[4-(tcrt-Butyl-dimcthyI-silanyloxy)-cyclohexyl]-2-oxo-pyrroid'in-}'y}metby}}-3\5'-dichloro-biphcny}-4-carboxyiic acid and thiomorphotine. Table I: The preparations in Tabic 1 may be prepared essentially as described in Preparation 6a except for using4'-{(R)cis-I-[4-(tcrt-Butyl-dimethyl-silanyloxy)-10 cyclohexyl]-2-oxo-pyrrolidin-3-ylmethyl}-3',5'-dichloro-biphenyl-4-carboxylie acid (Preparation 44) and the amine is replaced with the amine as indicated. WO 2007/124337 PCT/US2007/066921 WO 2007/124337 PCT/US2007/066921 Preparation 6 i CisI-[4-(tert-butyl-dimethyl-siIanyloxy)-cycIohexyl]-3-[3,5-dichIoro-4'-(l,l-dioxo- llambda*6*-thiomorpholinc-4-carbonyl)biphcnyl-4-ylmcthyI]-pyrrolidin-2-onc 5 Mix raccmic c/.v-l-[4-ften-butyl-dimethyl-silanyloxy)-cyc!ohexyl]-3-[3,5- dichloro-4'-(ihion]orpholine-4-carbonyl)-biphenyl-4-ylmethyl]-pyrrofidin-2-one(320 mg, 0.5 mmol) with 25 mL dichloromethane and treat with meta-chloroperbenzoic acid (2 equivalents). Stir the mixture 3 hours then purify by ion exchange chromaiography using and SAX cartridge and dichloromethane to recover 310 mg (92%) of a solid. 10 Table 2: The Preparation in Table 2 may be prepared essentially as described in Example 3 except for using the 3 \5'-dichlofQ-4'-[(R)-2'OxO~trans-1 -(4-trrisopropylsilanyIoxy cyciohexyl)-pyrrolidin-3-ylmethyl)-biphenyl~4-carboxylic acid and the amine is replaced with the amine as indicated. 15 Tabic 3: The Preparations in Tabic 3 may be prepared essentially as described in Preparation 8a except using 4'-((R)trans-l-[4-(tcn-Butyl-dimethyl-.silanyloxy)-cyclohexyl]-2-oxo-pyrro]idin-3-ylmethyl}-3',5'-dichloro-biphenyl-4-carboxylic acid (Preparation 19b) and the amine is replaced with the amine as indicated. WO 2007/124337 PCT/US2007/06692I Preparation 68 Trans-methanes ulfonic acid 4- {(R)-3-(3,5-dkh{oro-4 -(4-trifluoromethyI-piperidine-1 - carbonyl)-biphenyl-4-ylmethyl]-2-oxo-pyrrolidin-l-yl}-cyciohexyl ester 5 Dissolve (R)-3-{3,5-dichloro-4'-(4-tnfluoromethyl-piperidine-l-carbonyl)- biphenyl-4-ylme[hylJ-tfran5-l-(4-hydroxy-cyclohexyl)-pyrrolidin-2-one (0.419 g, 0.70 mmol) in 10 ml of dry dichloromethane at 0DC. Add triethylamine (0.18 ml, 1.41 mmol) WO 2007/124337 PCT/US2007/066921 followed by methanesulfonic anhydride (0.06ml, 0.77 mmol). Stir at room temperature for 5 hours. Quench with aqueous 1N hydrochloric acid and extract with ethyl acetate. Wash the extract with aqueous IN hydrochloric acid, saturated aqueous sodium bicarbonate then brine. Dry over magnesium sulfate, filter, and concentrate under 5 vacuum. Filter through a shon silica plug to recover 0.45 g (95%) of the title compound: MS (m/z): 675 (M+). Preparation 69 (R)-3-(2,6-dichioro-4-hydroxy-benzyl)-l-(tetrahydro-pyran-4-yl)-pyrroIidin-2-one Treat a solution of 4-(4-(R)-benzyl-2-oxo-oxazolidin-3-yl)-3-(4-benzyloxy-2,6-10 dichloro-benzyl)-4-oxo-butyraldehyde (Preparation 27) (10.4 g, 20 mmol) and 4- ami not etrahyd ropy ran (2 g, 20 mmol) in dichloromethanc (100 mL) with acetic acid (1 mL, 20 mmol). Stir the reaction I hr at room temperature then add sodium triacctoxyborohydridc (12.6 g, 60 mmol) and stir for an additional 4 hr at room temperature. Quench with water and separate the organic layer. Wash with brine, dry 15 over magnesium sulfate, filter, and remove the solvent under vacuum. Purify by silica gel column chromatography using hcxanes: ethyl acetate to afford 4.93 g (57%) of desired product: MS (m/z): 434 (M+). Preparation 70 (R)-3-(2,6-dichIoro-4-hydroxy-benzyl)-l-(tetrahydro-pyran-4-yl)-pyrrolidin-2-one 20 Hydrogenate a solution of (R)-3-(2,6-dichloro-4-hydroxy-benzyl)-l-(tetrdhydro- pyran-4-yl)-pyrrolidin-2-one (4.9 g, 11 mmol) in ethyl acetate (50 mL) with 20% by weight palladium hydroxide on carbon (0.5 g) and 1 atm of hydrogen. Filter through Celite® to remove the catalyst and concentrate under vacuum to afford 3.8 g (97%) of desired product. MS (m/z): 344 (M+). 25 Preparation 71 Trifluoro-methanesulfonic acid 3,5-dichloro-4-[(R)-2-oxo-I-(tetrahydro-pyran^4-yl)-pyrrol id in-3-ylmcthyl]-phenyl ester Cool a solution of (R)-3-(2,6-dich!oro-4-hydroxy-benzyI)-l-(tetrdhydro-pyran-4-y])-pyrrolidin-2-one (3.8 g, 11 mmol) in pyridine (50 mL) to 0°C and treat with 30 trifluoromeihanesulfonic anhydride (2.8 mL. 16.6 mmol). Allow the reaction to stir for 2 hr at room temperature then quench with IN hydrochloric acid and extract with ethyl acetate. Wash the organic layer with brine, dry over magnesium sulfate, and filter. WO 2007/124337 PCT/US2007/066921 Concentrate under vacuum to afford 4.58 g (87%) of desired produce MS (m/z): 475 (M+-). Preparation 72 3',5'-dichIoro-4'-[(R)-2-oxo-]-(tetrahydro-pyran-4-yl)-pyrrolidin-3'ylmethyl]-btphcnyl-4- 5 carboxylic acid methyl ester Treat a solution of trifluoro-methanesulfonic acid 3,5-dichloro-4-[(R)-2-oxo-l-(tetrahydro-pyrdn-4-yl)-pyrrolidin-3-ylmethyl]-phenyl ester (3.0 g, 6.3 mmol), 4-methoxycarbonylphenylboronic acid (2.3 g, 13 mmol), and letrakis(triphenylphosphine)palladium(0) (0.73 g, 0.63 mmol) in dirnethoxyethane (40 10 mL) with 2M aqueous potassium carbonate (9.5 mL). Heat the mixture to 80°C overnight. Cool to room temperature, quench with IN hydrochloric acid and extract with ethyl acetate- Wash the organic layer with brine, dry over magnesium sulfate, and filter. Purify the crude material by silica gel chromatography using hcxancs: ethyl acetate to afford 2.56 g (88%) of desired product: MS (m/z): 462 (M+). 15 Preparation 73 3',5'-dichloro-4,-[(R)-2-oxo-i-(tetrahydro-pyran-4-yl)-pyiTo]idin-3-ytmethyl]-biphenyl-4- carboxylic acid Treat a solution of 3',5'-dich!oro-4,-[(R)-2-oxo-l-(tctrahydro-pyran-4-yl)- pyrrolidin-3-ylmethyl]-biphenyl-4-carboxyIic acid methyl ester (2.56 g, 5.5 mmol) in 20 methanol (25 mL) with 5N aqueous sodium hydroxide (5.5 mL). Heat the reaction to 60°C and stir for 1 hr. Cool to room temperature, quench with IN hydrochloric acid and extract the aqueous with ethyl acetate. Wash the organic layer with brine, dry over magnesium sulfate, and filter. Remove the solvent under vacuum to afford 2.48 g(I00%) of desired product: MS (m/z): 448 (M+). 25 Preparation 74 (R)-3-[3,5-dichloro-4'-(44--difluoro-piperidine-l-carbonyl)-biphenyl-4-ylmethyl]-trans-l-{4-triisopropylsilanyloxy-cyclohcxyl)-pyrrolidin-2-one Prepare the title compound in a quantitative yield by coupling procedure 1 starting from 3,.5'-dichloro-4'-[(R)-2-oxo-trans-l-(4-triisopropylsitanyloxy-cyclohcxyl)-30 pyrrolidin-3-ylmeuiyl]-biphenyl-4-carboxylic acid and 4-difluoropiperidine hydrochloride. WO 2007/12-1337 PCT/US2007/066921 Mix 3',5'-dichIoro-4'-[(R)-2-oxo-trans-l-(4-TriisopropylsiIany!oxy-cyclohexyl)- pyrrolidin-3-ylmethyl]-biphenyl-4-carboxylic acid (0.15 g, 0.24 mmol), N-ethyl-N'-(3- dimethylaminopropyl)carbodiimide hydrochloride (0.058 g, 0.3mmol), N- methylrnorpholine (0.1 mL, 0.9 mmol), hydroxy benzotriazole (0.041 g, 0.3 mmol) and 4- 5 diftuoropipcridine hydrochloride (0.08 g. 0.49 mmol) in CH2CI2 (15 mL) . Stir the reaction for 12 hours at room temperature then quench with IN aqueous hydrochloric acid and extract with ethyl acetate. Wash Ihe extract with saturated aqueous sodium bicarbonate then brine. Dry over magnesium sulfate, filter, and concentrate. Purify by silica gel chromatography to recover 0.175 g (100%) of the title compound. 10 Preparation 75 (RV3-[3,5-dichloro-4'-(4-trifluoromethyI-piperidine-l-carbonyl)-biphenyl-4-ylmethyl]-trans-l-(4-triisopropylsiIany]oxy-cyclohcxyl)-pyrrolidin-2-one Prepare the litlc compound in a 51% yield by coupling procedure 1 starling from 3',5'-dichloro-4'-[(R)-2-oxo-trans-l-(4-triisopropyIsilanyloxy-cyclohexyl)-pyTToiidin-3-15 ylmethyi]-biphenyl-4-carboxylic acid and 4-trifluoromethyl-piperidine hydrochloride. Mix 3',5'-dichloro-4'-[(R)-2-oxo-trans-1 -(4-triisopropylsilanyloxy-cyclohexyl)-pyrrolidin-3-ylmethyi]-biphcnyl-4-carboxylic acid (0.94 g, 1.52 mmol). N-ethyl-N'-(3-dimcthylaminopropyl)carbodiimidc hydrochloride (0.358 g. 1.83mmo!), N-methylmorpholine (0.50 mL, 4.57 mmol), hydroxy benzotriazole (0.511 g, 1.52 mmol) 20 and 4-trifluoromethyl-piperidine hydrochloride (0.466 g, 3.05 mmol) in CH2O2 (15 mL) . Stir the reaction for 12 hours at room temperature then quench with IN aqueous hydrochloric acid and extract with ethyl acetate. Wash the extract with saturated aqueous sodium bicarbonate then brine. Dry over magnesium sulfate, filter, and concentrate. Purify by silica gel chromatography to recover 0.586 g(5l%) of the title compound: MS 25 (m/z): 753 (M+). Preparation 76 3-[3-Chloro-2'-(4-mcthyl-pipcrazinc-l-carbonyl)-biphenyl-4-yImethyl]-l-cyclohexyl- pyrrolidin-2-one hydrochloride salt Charge a vial with 3'-chloro-4'-(l-cyclohcxyl-2-oxo-pyrrolidin-3-ylmethyl)-30 biphcnyl-2-carboxylic acid (70 mg, 0. i 7 mmol), EDCI (65 mg, 0.34 mmol) and HOBt (23 mg, 0.17 mmol). Dissolve in DMF (0.1 M) and add trielhylamine (95 uL, 0.68 mmol) WO 2007/124337 PCT/US2007/066921 and N-methyl pipcrazinc (34 mg, 0.34 mmol). Stir at room temperature overnight. Pour into water and extract with ether. Dry over sodium sulfate, filter and concentrate. Purify over silica gel. Dissolve the residue in methylene chloride and acidify with 4N HC1 in dioxane. Concentrate in vacuo which affords 57 mg (63%) of the title compound: Mass 5 spectrum m/z = 494.3 (M+H-HCI). Preparation 77 4-Bromo-2-lrifluoromclhoxy-benzaIdchydc Add 4-bromo-1 -iodo-2-(trifluoromethoxy)benzene (22.04 g, 60 mmol) to a 1000 mL 3-neck flask equipped with a magnetic stir bar, thermocouple, addition funnel, and N2 10 inlet and replace the atmosphere in the flask with nitrogen. After adding anhydrous THF (300 mL), cool the mixture to -74°C and treat dropwisc with a solution of/-butyllithium (70 mL of 1.7 M solution. 120 mmol). Stir the resulting solution for y0 minutes and then treated dropwise with a solution of /V-formyl morpholine (14.52 g, 126 mmol) in THF (15 mL). Stir the mixture an additional 15 minutes at -74°C and then allow to warm,to 0°C 15 over 1 hour. Quench the reaction by the adding 0.25 M citric acid (200 mL) and extract with ethyl acetate (1 * 300 mL). Wash the organic layer with saturated sodium chloride solution (1 * 200 mL), dry over anhydrous magnesium sulfate, filter through Celite€'. and concentrate to an oil. Purify the crude product via silica gel chromatography eluting with hcxanes to afford 8.24 g (51%) of the product as white crystals: !H NMR (300 20 MHzpCDCb) S 10.32 (s. 1H), 7.85 (d, .7=8.3 Hz, 1H),'7.63-7.53 (m, 2H). Preparation 78 (4-Bromo-2-trifluoromethoxy-phenyl)-methanol Prepare the title compound essentially by the method of Preparation 4 in a 98 % yield starting from 4-bromo-2-trifluoromethoxy-benzaldehyde: 'H NMR (300 25 MHz,CDCb) 6 7.50-7.44 (m, 2H). 7.43-7.39 (m, 1H), 7.74 (d,7=5.8 Hz, 2H), 1.79 (t 7=6.1 Hz, IH). Preparation 79 4-Bromo-1 -bromomethyl-2-trifluoromethoxy-benzene Add (4-bromo-2-(trifluorornethoxy)phenyl)mcthanol (9.757 g, 36 mmol) and 30 dichloromethanc (180 mL) to a 500 mL flask equipped with a magnetic stir bar and N2 inlet. Cool the solution to 0°C and then treat with triphenylphosphme (11.33 g, 43 mmol) WO 2007/124337 PCT/US2007/066921 and carbon telrabromidc (14.26 g, 43 mmol). Stir the reaction at 0°C for 45 minutes, warm to room temperature and stir an additional 1 hour. Wash the reaction with water (2 * 180 mL) and saturated sodium chloride solution (I * 180 mL), then dry over anhydrous magnesium sulfate. Filter through Celite® and concentrate under vacuum to dryness. 5 Dissolve the residue in hexanes, filter to remove the triphenyl phosphine oxide, and concentrate to a colorless oil. Purify the crude product via silica gel chromatography cluiing wilh hexanes to afford 10.5 g (88%) of the product as a colorless oil: lHNMR (300 MHz,CDCh) 8 7.46-7.40 (m, 2H), 7.38-7.33 (m, 1H), 4.46 (s, 3H). Preparation 80 10 4-Bromo-l-dibromomethyl-2-trifluoromethyl-benzene Add 4-methyI-3(trif!uoromclhyl) bromo benzene (5.0 g, 20.9 mmol), N-bromosuccinimide (9.308 g, 52.3 mmol), benzoyl peroxide (200 mg. 0.84 mmol), and carbon tetrachloride (100 mL) to a 500 mL flask equipped with a magnetic stir bar, reflux condenser, and N2 inlet. Reflux the reaction with stirring for 16 hours then cool to room 15 temperature- Concentrate the mixture under vacuum to an orange residue and add hexanes. Filter through a small plug of silica gel and concentrate the filtrate under vacuum to give 7.6 g (92%) of the product as a white solid: 'H NMR (300 MHz,CDCh) o 8.08 (d, IH,.7=8.3 Hz), 7.80 (dd, 1H, .7=1.8 Hz,.7=8.6Hz), 7.70 (d, 1H, J= 1.9 Hz), 7.91 (s. IH). 20 Preparation 81 4-Bromo-2-trifluoromethyl-benzaldehyde Combine 4-bromo-l-(dibromomcthyl)-2-(trifluoromethyl)benzene (6.66 g, 16.8 mmol), silver nitrate (14.8 g, 87.3 mmol), THF (250 mL), and water (35 mL) in a 500 mL flask equipped with a magnetic stir bar, reflux condenser, and N2 inlet. Reflux the 25 mixture while stirring for 2.5 hours then cool to room temperature. Filter the reaction through Celite®, add ethyl acetate (250 mL) and wash with water'(2 * 200 mL) then saturated aqueous sodium chloride solution (1 * 200 mL). Dry over anhydrous magnesium sulfate, concentrate to an orange oil, and purify the crude product via silica gel chromatography cluting with hexanes to afford 3.46 g (81%) of the product as a clear 30 oil: 'H NMR (300 MHz,CDCh) 6 10.35-10.33 (m. lH),8.0(d, lH.7=8.3Hz), 7.93 (d. 1H,.7=1.4 Hz), 7.86(dd. lH,y=L2Hz, J=8.3Hz). WO 2007/124337 PCT/US2007/066921 Preparation 82 4-Bromo-l-bromomethyl-2-trifluoromethyl-benzene Treat a mixture of 4-bromo-2-(trifluoromethyl) benzaldehyde (6.52 g, 25.8 mmol) and methanol (250 mL) in a 500 mL flask with sodium borohydride (778 mg, 20.6 5 mmol). Stir the reaction at room temperature for 1 hour then dilute with ethyl acetate (300 mL). Wash wilh water (2 * 200 mL) and saturated sodium chloride solution (1 * 200 mL), then dry over anhydrous magnesium sulfate. After filtering, concentrate the solution under vacuum to dryness. Add dimethylformamide (250 mL) to the residue and cool in an ice bath before treating widi carbon tetrabromide (12.78 g, 38.5 mmol) and 10 triphenylphosphine (10.11 gf 38.5 mmol) for 3 hours. Add ethyl acetate (300 mL) and wash with water (2 * 200 mL) then saturated sodium chloride solution (1 * 200 mL). Dry over anhydrous magnesium sulfate and concentrate under vacuum. Purity the crude product via silica gel chromatography cluting with hcxanc^ to afford 6.02 g (74%) of the product as ariear oiV. 'H"NMR (300MHz,CDaj)S 11%{&, 1H, J=\1.9Hz),7.68166, m. 15 y=1.9Hz,y^8.3Hz), 7.47 (d, 1H, 7=8.3 Hz), 4.57 (s, 2H). Table 4: The Preparations in Table 4 are prepared essentially by the method of Preparation 8 except for the substitution of the 2-bromomethyl-I,3-dichIoro-5-methoxy-benzene wtUi the reagent as shown in column 3. Preparation Chemical name Reagent used Physical data 83 3-(4-Bromo-2-trifluoromethoxy-benzy 1)-1 -cydohexyl-pyrrolidin-2-one Preparation 79 MS (m/z): 421 (M+I) 84 3-(4-Bromo-2-trifluoromethyl-benzyl)-l -cyclohexyl-pyrroiidin-2-one Preparation 82 MS (m/z): 404 (M+I). 20 Preparation 85 4,_(l-_Cyclohexyl-2-oxo-pyrrolidin-3-ylmethyl)-3'-trifluoromethoxy-biphenyl-4- carboxylic acid methyl ester WO 2007/124337 PCT/US2007/066921 Combine 3-(4-bromo-2-(trifIuoroniethoxy)benzy])-l-cyclohexylpyrrolidin-2-one (9.68 g, 23.0 mmol), 4-(methoxycarbonyl)phenylboronic acid (8.29 g, 46.1 mmol), dichloro[ 1 ,r-bis(diphcnylphosphino)ferrocene]palladium (II) (2.87 g, 3.9 mmol), dioxanc (400 mL) and DMSO (8 mL) in a 1 L flask equipped with a magnetic stir bar, 5 reflux condenser, and N2 inlet. Add potassium acetate (9.04 g, 92.1 mmol) and heat to 80°C while stirring for 2 hours. Cool to room temperature, filter through silica gel and rinse with ethyl acetate (400 mL). Wash with water (2 * 400 mL) and saturated sodium chloride solution (1 * 400 mL), then dry over anhydrous magnesium sulfate and concentrate to an oil. Purify the crude product via silica gel chromatography eluting with 10 10% to 20% ethyl acetate in hexancs to afford 9.86 g (90%) of the product as a white solid. MS(m/z):476(M+l). Preparation 86 4'-(l-Cyclohexyl-2-oxo-pyrTolidi(i-3-ylmcthyl)-3'-trifiuoromcthyl-biphcnyl-4-carboxylic acid methyl ester 15 Prepare the title compound essentially by the method described for Preparation 85 except use 3-(4-Bromo-2-trifluoromethyl-benzyl)-l-cyclohexyl-pyrroIidin-2-one {Preparation 84). MS (m/z): 460 (M+l). Preparation 87 4'-(l-Cyclohexyl-2-oxo-pyrrolidin-3-ylmethyl)-3'-trifluoromethoxy-biphenyl-4' 20 carboxylic acid Combine methyl 4'-((l-cyclohexyl-2-oxopyrrolidin-3-yl) methyl)-3'-(trifluoromethoxy)biphenyl-4-carboxylate (9.15 g, 19.2 mmol),THF (175 mL) and water (175 mL) in a 500 mL flask equipped with a magnetic stir bar. While stirring in an ice bath treat the mixture with lithium hydroxide monohydratc (2.42 g, 57.7 mmol). Stir the 25 reaction for 30 minutes, warm to room temperature and stir an additional 16 hours. Dilute with ethyl acetate (250 mL) and wash with water (250 mL). Add hydrochloric acid (2N) to the aqueous layer until it is acidic then extract with ethyl acetate (2 x 300 mL). Wash the extracts with aqueous saturated sodium chloride solution (1 * 250 mL), dry over anhydrous magnesium sulfate and concentrate to afford 6.98 g (79%) of the 30 product as a white solid: MS (m/z): 462 (M+t). WO 2007/124337 PCT/US2007/066921 Preparation 88 4'-(l-CyclohexyI-2-oxo-pyrro]idin-3-ylmethy!)-3'-trifluoromethyl-biphenyl-4-carboxylic acid Prepare the title compound essentially by the method described for Preparation 87 5 except use 4'-( I -Cyclohexy]-2-oxo-pyrrolidin-3-ylmethyl)-3,'trifluoromethyI-biphenyl-4-carboxylic acid methyl ester. MS (m/z): 446 (M+l). Table 5: The Preparations in Table 5 are prepared essentially by the method of Preparation 74 except for the substitution of 4-difluoropiperidine hydrochloride with the 10 reagent as shown in column 3. WO 2007/124337 PCT/US2007/066921 Preparation 93 (R)-c/s-l-[4-(tert-Butyl-dimethyl-silanyloxy)-cyclohexyl]-3-{3,5-dichloro-4'-[4-(2-fluoro- ethyl)-piperazine-l-carbonyl]-biphenyl-4-ylmethyl}-pyrrolidin-2-one 5 Prepare the titled compound by the procedure in Preparation 6a using 4'-{(R)-c/s- l-[4-(tcrt-ButyI-dimethyl-silanyloxy)-cyclohexyl]-2-oxO'pyrrolidin-3-ylmethyl}-3',5'-dichloro-biphenyl-4-carboxylic acid and l-(2-fIuoro-ethyl)-piperazine. Preparation 94 (R)-3-(4-Benzyloxy-2,6-dichloro-benzyl)-wafl5-l-(4-methoxy-cyclohexyl)-pyiTolidin-2- 10 one Suspend sodium hydride (0.45 g. 11.15 mmol) in 10 ml of dry dimethylformamidc atO°C. After stirring for 10 minutes, add the solution of (R)-3-(4-bcnzyloxy-2.6 dichloro-bcnzyl)-trans-l-{4-hydroxy-cyc]ohexyI)-pyrro]idin-2-one (2.50 g, 5.58 mmol) in 5 ml of dry dimethylformamide. Stir the resulting mixture for 15 minutes at 0°C. Add 15 iodomethane (1.40 ml, 22.32 mmol) and allow the mixture to warm to room temperature. Stir the reaction at room temperature for an additional 12 hours then quench with water and filter the white precipitate. Dry under vacuum to recover 2.59 g of the title compound: MS (m/z): 462 (M+). Preparation 95 20 (R)-3-(2,6-Dichloro-4-hydroxy-benzyl)-trans-l-(4-methoxy-cyclohexyl)-pyrrolidin-2-one Stir(R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-trans-l-(4-mcthoxy-cycIohexyl)-pyrrolidin-2-one (2.59 g, 5.61 mmol) and palladium hydroxide (20% on carbon) (0.300g, 10% by weight) in 100 ml of ethyl acetate. Bubble hydrogen gas through the solution whiie stirring at room temperature for 5 minutes. Stir the mixture under the hydrogen gas 25 atmosphere for 5 hours. Filter through Celite® and concentrate under vacuum to recover 2.08 g of the title compound (99%). MS (m/z): 372 (M+). Preparation 96 Trifluoro-methanesulfonic acid 3,5-dichloro-4-[(R)-trans-l-(4-methoxy-cyclohexyl}-2- oxo-pyrrolidin-3-ylmethyl)-phenyl ester 30 Dissolve (R)-3-{2,6-dichloro-4-hydroxy-benzyl)-trans-1 -(4-methoxy-cyclohexyi)- pyrrolidin-2-one (2.08 g, 5.63 mmol) in 15 ml of dry pyridine at 0°C. Add WO 20(17/124337 PCT/US2G07/066921 trifluoromethanesulfonic anhydride (1.42 ml, 8.45 mmol) dropwise. Stir at room temperature for 2 hours. Quench with IN HCI and cxtracl with ethyl acetate. Wash the extract with 1N HCi, saturated aqueous sodium bicarbonate then brine. Dry over magnesium sulfate, filter, and concentrate under vacuum. Purify by flash column 5 chromatography recover 2.134 g (76%) of the title compound: MS (m/z): 504 (M+). Preparation 97 3,,5'-Dichloro-4,-[(R)-trans-l-(4-mcthoxy-cycIohcxy!)-2-oxo-pyrrolidin-3-ylmcthyl]- biphenyl-4-carboxylic acid methyl ester Mix trifluoro-methanesulfonic acid 3,5-dichloro-4-[(R)-trans-l-(4-methoxy- 10 cyclohexyl)-2-oxo-pyrroIidin-3-ylmelhyl]-phenyl ester (2.134 g, 4.24 mmol). (4- mefhoxycarbonylphenyDboronic acid (0.926 g, 5.09 mmol), tetrakis(triphenylphosphine)palladium(0) (0.490 g, 0.42 mmol) and 6.36 ml of 2M solution of K2CO3in DME (10 mL). Stir for 12 hours at 80°C. Quench the reaction with water and extract with ethyl acetate. Wash the extract with brine and dry over 15 magnesium sulfate. Purify by flash chromatography to recover 1.68 g(8l%) of the title compound: MS (m/z): 490 (M+). Preparation 98 3',5'-Dichloro-4'-[{R)-trans-l-(4-mcthoxy-cyclohcxyl)-2-oxo-pyrrolidin-3-ylmethyl]- biphenyl-4-carboxylic acid 20 Combine 3',5'-dichloro-4'-[(R)-trans-l-(4-methoxy-cyclohexyl)-2-oxo-pyiTolidin- 3-y1methyl]-biphenyl-4-carboxylicacid methyl ester (1.60 g, 3.3 mmol), MeOH (15 mL) and 1N NaOH solution (15mL). Stir for 3 hours at 70°C. Concentrate under vacuum and quench with IN HCI. Filter the white precipitate and rinse the solid with water. Dry under vacuum to recover 1.32 g (86%) of the title compound: MS (m/z): 476 (M+). 25 Example I 3',5'-dichloro-4'-(l-cyclohexyl-2-oxo-pyrrolidin-3-yImethyl)-3-fluoro-biphcnyl-4- carboxylic acid amide WO 2007/124337 PCT/US2007/066921 Add potassium carbonate (83 mg, 0.6 mmol) and hydrogen peroxide (30% in water, 0.5 mL) to a solution of Preparation 13 (3',5'-dich]oro-4,-(l-cyclohcxyl-2-oxo- pyrrolidin-3-yimethyl)-3-fluoro-biphenyl-4-carbonitrile) (88 mg, 0.2 mmol) in DMSO (3 mL). Stir the reaction at room temperature for 12 h. Partition the mixture between ethyl 5 acetate (20 mL) and water (20 mL). Separate the organic layer, wash three times with water (15 mL each) then brine (15 mL). After drying the organic layer over sodium sulfate, filter and concentrate under vacuum. Purify the residue by silica gel chromatography with 1:1 ethyl acetate/hexane to afford the title compound: MS (m/z): 463 (M+). 10 Example 2 l-Cyclohexyl-3-{3.5-dichloro-4'-[4-(2-hydroxy-cthyl)-piperdzine-l-carbonyl)-biphenyl-4-ylmethyI}-pyrrolidin-2-one hydrochloride salt o I 0 Combine Preparation 10 (trifluoro-mcthanesulfonic acid 3,5-dichloro-4-(l-15 cyclohexyl-2-oxo-pyrrolidin-3-ylmelhyl)-phenyl ester) (250 mg, 0.53 mmol), 4-chlorocarbonylphenylboronic anhydride (263 mg, 0.53 mmol) and Pd(PPhj)4 (61 mg, 0.053 mmol) and purge with nitrogen. Add 2-(pipcrazin-l-yl)ethanol (0.32 mL, 2.6 mmol) followed quickly by dimethoxyethane (5 mL) and 2M sodium carbonate (1 mL) and heat to 80°C for 1 hour. Cool to room temperature and pour into IN sodium 20 hydroxide. Extract with ethyl acetate and wash the organic layer twice with water, followed by brine. Dry over sodium sulfate and concentrate in vacuo. Purify on SCX column (load and wash with methanol, elute with 2M ammonia in methanol). Dissolve resultant oil in methylene chloride. Add 2M hydrochloric acid in ether (1 mL) and concentrate under vacuum. Re-dissolve in small amount of methylene chloride and add 25 dropwisc to vigorously stirred ether. Filter precipitate and dry in vacuum oven to afford 231 mg (74%) of the title compound: MS (m/z): 558 (M+). Example 3 l-cyclohexyl-3-[3,5-dichloro-4*-(piperidine-l-carbonyl)-biphenyl-4-ylmethyl]-pyrrolidin- 2-onc WO 2007/124337 PCT/US2007/066921 Coupling Procedure 1 Dissolve 3',5'-dichloro-4(1-cyc!ohcxyl-2-oxo-pyrrolidin-3-ylmethy!)-biphenyl-4- carboxylic acid (0.200g, 0.448 mmol) in dichloromethane (5 mL) and add piperidine (50 mg., 0.582 mmol) as well as diisopropylcthylamine (0.26 rnL, 1.48 mmol) under inert atmosphere. Chill reaction on ice bath (0°C) and add (N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydrochloride (0.112 g, 0.582 mmol). Allow reaction to rise to room temperature over 2 hours, dilute with dichloromethane (50 mL) and wash with 1.0 N sodium hydroxide (30 mL) and brine (30 mL). Collect organic phase, dry over anhydrous magnesium sulfate and concentrate under reduced pressure. Purify by silica gel chromatography to obtain 109 mg (47%) of the product as an off white solid: MS (m/z): 513 (M+). Table 6: The Examples in Tabic 6 may be prepared essentially as described by the coupling procedure I in Example 3 except for the amine is replaced with the amine as indicated. WO 2007/124337 PCT/US2OO7/066921 pyrrolidin-3-ylmethyl)-bipheny[-4-carboxylic acid bis-(2-hydroxy-ethyl)-amide Preparation 6a l-cyclohexyl-3-[3,5-dichloro-4'-(4-methyI-pipenizine-l-carbonyl)-biphenyl-4-y]mcthyl]- pynrolidin-2-one .CH, Coupling Procedure 2 Dissolve 3'. 5,-dichloro-4'-(l-cyclohexyl-2'Oxo-pyrrolidin-3-yimethyi)-biphenyl-4-carboxylic acid (10 g, 22.40 mmol) in dichloromethane (100 mL) and add 1,1'-carbonyl-diimidazole (3.81 g, 23.5 mmol). Stir under argon atmosphere at room temperature 1 hour then add N-methylpiperazine (2.36 g, 23.5 mmol). Stir I hour, dilute reaction with water, separate layers then wash sequentially with 1.0 N sodium hydroxide, water and brine. Collect organic phase, dry over anhydrous magnesium sulfate and concentrate under reduced pressure. Purify via flash chromatography using 5% methanol in dichloromethane to recover 10.8 g (78%) of the product as a white solid: MS (m/z): 528 (M+). Tabic 7: The Examples or preparations in Table 7 may be prepared essentially as described by coupling procedure 2 in Preparation 6a except for the amine is replaced with the amine as indicated. Example or Prepara¬tion Structure and name Amine Mass Spec WO 2007/124337 PCT/US2007/U66921 WO 2007/124337 PCTAJS2007/066921 WO 2007/124337 PCT/US2007/066921 Jfr*\l WO 2007/124337 PCT/US2007/066921 jK-'fr- WO 2007/12433* PCT/US2OO7/066921 ^3 WO 2007/124337 PCT/WS2007/066921 jx*H WO 2007/124337 PCT/US2007/II66921 WO 2007/124337 PCT/US2007/066921 PCT/US2007/066921 Alternate procedure to make Example 7 and the HCi salt thereof: Place 3',5'-dichloro-4'-( 1 -cyclohexyl-2-oxo-pyrrolidin-3-yimethyl)-biphenyl-4-carboxylic acid (2,277 g. 5.1 mniol) in dry dichloromclhanc (50 mL.i and add oxalyl chloride (647 mg, 5.1 mmol). and s.t\r for one hour. Concentrate »o give 3\5'-dichtoro-4'-(l-cydohexy 1-2-oxo-pyrrolidin-3-y|mcthyl)-biphenyl-4-acid chloride. Dissolve in THF (20 mL) and add l-meihytpiperazine (1.2 g, 12.4 mmol) and stir for 16 hours. Add dichloromethane and wash with IM NaOH and water. Dry over sodium sulfate, filter, and concentrate. Dissolve in dichloromethane (10 mL) and add HCI in ether (2M, 1 mL) and concentrate to give 67 mg (36%) of the title compound as a tan solid. Mass spectrum (apci) m/z=556.2 (M+H). Example 39 {[3,,5'-dichloro-4'-(l-cyclohexyl-2-oxo-pyrTolidin-3-y!methyl)-biphenyl-4-carbonyl]- aminoj-acclicacid Coupling Procedure ~? Suspend 3',5'-dichIoro-4'-(l-cyclohcxyI-2-oxo-pynrolidin-3-ylmcthyl)-biphenyl-4-carboxylic acid (0.25g, .56 mmol) and N-hydroxysuccinimide (0.078g, .67 mmol) in anhydrous dioxane (5 mL). Stir at room temperature and add N,N2 dicyclohexylcarbodiimide (0.138g, .67 mmol) dissolved in anhydrous dioxane (5 mL). WO 2007/124337 PCT/US2007/066921 drop-wise, over 20 minutes. Stir reaction overnight. Filter off white precipitant (urea) and wash with cold dioxane (10 mL). Add glycine (0.057g, 0.75 mmol) and sodium bicarbonate (0.063g, 0.75 mmol) to the solution (lOmL, 0.56 mmol). Stir the reaction sealed, at room temperature overnight. 5 Concentrate the volume of the reaction mixture by 2/3 under reduced vacuum, acidify with concentrated hydrochloric acid at 0°C and collect the resultant white solid via filtration. Purify via flash chromatography by eluding with gradient of 5% ' isopropanol/93% dichloromethane/2% acetic acid to 20% isopropanol/78% dichloromethane/2% acetic acid to recover 0.097g (35%) product as a white solid: MS 10 (m/z): 503 (M+). Table 8: The Examples in Table 8 may be prepared essentially as described by coupling procedure 3 in Example 39 except for the amine is replaced with the amine as indicated WO 2007/124337 PCT/US2007/066921 Example 43 .5'-Dichioro- 4'-( !-cyclolicxy!-2-oxo-pyrTOlidin-3-ylincihy!)-biplieuyl-4-carboxyiic acid melhyl-f IH-ietrazoi-5-y])-amidc CI Coupling Procedure 4 Treat a solution of 3',5'-dichloro-4,-(l-cyclohexyl-2-oxo-pyrrolidin-3-ylmethyl)-biphcnyI-4-carboxylic acid ("0.50 g, i.12 mmo!) in dichloromcihanc (15 mL)with 3 drops ofdirnethylformamidethen oxalyl chloride (0.14 g, 1.14 mmol) and stir for 1 hour at 10 room temperature. Add this solution dropwisc to another solution of methyl-(lH-tctrazol-5-y])-amine [Finnegan.W.G. el. al.JOC. 1953, 18, 770] (0.166 g. 1.67 mmol), triethylamine(0.34 g, 3.36 mmol) and DMAP (0.014 g, 0.114 mmol) in tctrahydrofuran (10 mL) at 0°C. Warm the reaction to room temperature and stir for 16 hours under N3. Quench the reaction with I N hydrochloric acid, dilute with water and extract with 15 dichloromethane. Dry the organic layer with sodium sulfate and purify the crude product by HPLC to afford 188 mg (32%) of the title compound: MS (m/z): 527 (M +). Tabic 9: The Examples in Table 9 may be prepared essentially as described by coupling procedure 4 in Example 43 except for the amine is replaced with the amine as indicated. Example Structure and name Amine Mass Spec WO 2007/124337 PCT/US2007/066921 Example 46 l-cyclohexyl-3-[3,5-dichloro-4'-(4-methyl-piperazine-l-carbonyl)-bLphenyl-4-ylmethyl]- pyrrolidin-2-one hydrochloride HClO Dissolve 10.6 g (20.07 mmoi) racemic 1 -cyclohexyl-3-[3,5-dichioro~4'-(4-methyl-piperazine-l-carbonyl)-biphenyM-ylmethyl]-pyrrolidin-2-oiie in dichiorometliane (-20 rnL)and, while rapidly stirring, slowly add 21 mL of IN hydrochloric acid in diethyl ether. Stir rapidly for-15 minmes, filter and rinse the solid with diethyl ether. Vacuum 10 dry to yield 11.2 g (100%) of a white solid: MS (m/z): 528. WO 2007/124337 PCT/US2007/06692I Alternative procedure to prepare Example 46: Using the procedure to synthesize Preparation 76 and using reagents 3',5'-dichIoro-4'-{l-cyclohexy!-2-oxo-pyrrolidin-3-ylmethyl)-biphenyl-4-carboxylic acid (350 mg, 0.78 mmol) and ^-methyl piperazine (157 mg, 1.6 mmol) affords 103 mg (23%) of the title compound: Mass spectrum (apci) 5 m/z=528.2 (M+H-HCI). Example 47 3,5'-dichloro-4(-cyclohexyl^-oxo-pyrrolidin-3-ylmcthyll-biphcnyl^-carboxylic acid azetidin-3-ylamide 10 Dissolve racemic 3', 5'-dichloro-4(l-cyclohexyl^-oxo-pyrrolidin-3-ylmethyl)- biphenyl-4-carboxylic acid (0.200g, 0.448mmol) in dichloromethane (5 mL) and add 1,1 '-carbonyl-diimidazole (0.1 lOg, 0.670 mmol). Stir under argon atmosphere at room temperature and check reaction progress via TLC. Add 3-amino-azetidine-l-carboxylic acid tcrt-buiyl ester (O.093g, 0.538 mmol) and continue to stir, checking progress via 15 LC/MS. Once starting material has been fully consumed, dilute reaction with dichloromethane (50 mL) and wash with 1.0 N sodium hydroxide (30 mL) then brine (30 mL). Collect the organic phase, dry over anhydrous magnesium sulfate and concentrate under reduced pressure. Dissolve the residue in dioxane (20 mL), add 4N hydrochloric acid -dioxane (10 mL) and stir 1/2 hour to obtain an oily residue in reaction vessel. 20 Concentrate and then dilute with dichloromethane (100 mL). Quench with saturated sodium bicarbonate solution (50 mL), dry organic phase of magnesium sulfate and concentrate to foam. Purify via flash chromatography, elude with gradient of 100% dichloromethane to 10% ammonia methanol/90% dichloromethane to obtain 0.014g (7.6%) of a white foam: MS (m/z): 500 (M+). 25 Example 48 3',5'-dichloro-4'-(l-cyclohexyl-2-oxo-pyrrolidin-3-ylmcthyl)-biphenyl-4-carboxylicacid (3-amino-cyclohexyl)-amidc WO 2007/124337 PCT/US2007/066921 Dissolve racemic 3', 5*-dichloro-4(1-cyclohexyI-2-oxo-pyrrolidm-3-ylmethyl)-biphenyI-4-carboxylic acid (1.00 eq.) in dichloromethane (5-10 mL) and add 1,1'-carbonyI-diimidazole (1.50 eq.)- Stir under argon atmosphere at room temperature and 5 check reaction progress via TLC. Add (3-amino-cyclohexyi)-carbamic acid tert-butyl ester (1.05-2.0 eq.) and continue to stir, checking progress via LC/MS. Once starting material has been fully consumed, dilute reaction with dichloromethane (50 mL) and wash with 1.0 N sodium hydroxide (30 mL) and brine (30 mL). Collect the organic phase, dry over anhydrous magnesium sulfate and concentrate under reduced pressure. 10 Purify via flash chromatography by eluding with gradient of 100% dichloromethane to 10% ammonia methano!/90% dichloromethane to recover {l-[3',5'-dichloro-4,-{l-cyclohcxyl-2-oxo-pyrrolidin-3-ylmclhyl)-biphcnyI-4-carbonyl]-piperidin-3-yl}-carbamic acid tert-butyl ester. Dissolve the {l-[3',5'-dichtoro-4'-(l-cyclohexyl-2-oxo-pyrroIidLn-3-ylmethy0-biphenyl-4-carbonyl]-piperidin-3-yl} -carbamic acid tert-butyl ester (0.40. 15 0.65mmol) in dioxane (20 mL), add 4N hydrochloric acid -dioxane (10 mL) and stir 30 min. Concentrate under vacuum, dilute in dichloromethane (100 mL) and add saturated aqueous sodium bicarbonate (50 mL). Dry the organic phase with magnesium sulfate and concentrate to a foam: MS (m/z): 528 (M+). Example 49 20 l-cyc]ohexyl-3-[3,5-dichloro-4'-(piperazine-l-carbonyl)-biphenyl-4-ylmethyl]- pyrrolidin-2-one Dissolve racemic 4-[3',5'-dichloro-4'-(l-cyclohexyl-2-oxo-pyrrolidin-3-ylmethyl)-biphcnyl-4-carbonyl]-piperazine-l-carboxylic acid tert-butyl ester (0.843g, 1.37 mmol) in 25 dichloromethane (25 mL) and cool in ice bath to 0°C while stirring under an inert WO 2007/124337 PCT/US2007/06692J atmosphere. Add triethylsilane (0.5 mL) and trifluoroaceiic acid (5.0 mL) lo the mixture and allow the tcmpcraiurc to rise (o room temperature. Monitor the reaction via TLC. Once starting material is consumed, dilute the reaction with dichloromethane and quench with saturated sodium bicarbonate. Collect the organic phase and the extract aqueous phase with dichloromethane (2x50 mL). Combine organic phases and dry over magnesium sulfate. Extract desired material with resin bound acidic media (SCX) to obtain 0.656 g (93%) of white solid: MS (m/z): 514.0 (M+l). Example 50 3\5'-dichloro-4(1-yc!ohexy!-2-oxo-pyrrolidin-3-ylmethyl)-biphenyl-carboxylic acid (4-amino-cyclohexyl)-amide Dissolve racemic l-[3\5'-dichloro-4'-(l-cyclohexyl-2-oxo-pyrrolidin-3-ylmethyl)-biphcnyl-4-carbonyl]-piperidin^-yl}-carbamic acid tert-butyl ester (1.2lg. 1.92 mmoH in dichloromethane (25 mL) and cool in an ice bath (0°C) while stirring under inert atmosphere. Add triethylsilane (0.5 mL) and trifluoroacetic acid (5.0 mL) to the mixture and allow the temperature to rise to room temperature. Once starting material is consumed, dilute the reaclion with dichloromethane and quench with saturated aqueous sodium bicarbonate. Separate the layers and extract the aqueous phase with dichloromethane (2x50 mL). Combine the organic phases and dry over magnesium sulfate. Exiract desired material with resin bound acidic media (SCX) to obiain 0.945 g (93%) of a foam (93%): MS (m/z) 528 (M+). Example 51 3\5'-dich]oro-4'-( 1 -cycluhexyl-2-oxo-pyrrolidin-3-ylmethyl)-biphenyl-4-carboxyIic acid (2-dimethylamino-ethyl)-amideN-oxide WO 2007/124337 PCT/US20O7/0r>6921 Dissolve racemic 3',5'-dichloro-4'-(l-cyclohexyl-2-oxo-pyrToIidin-3-y]methyl)-biphenyl-4-carboxylic acid (2-dimethylamino-ethyI)-methyl-amide (0.097g, 0.183 mmol) in dichloromeihane (5 mL) under argon atmosphere. Add 3-chloropcroxybcnzoic acid (0.045g, 0.200 mmol) and stir at room temperature for I hour. Concentrate under reduced 5 pressure and purify via flash chromatography by eluding with gradient (100%) dichloromeihane to 25% methanol/ 75% dichloromethane to obtain 0.086g (87%) of a white solid: MS (m/z): 546 (M+). Example 52 3',5'-dichloro-4'-(l-cyc!ohexyl-2-oxo-pyrTolidin-3-y]methy!)-biphenyl-4-carboxylic acid 10 (l-oxy-pyridin-4-y]methyl)-amide CI o Dissolve racemic 3',5'-dichloro-4'-(l-cyclohexyI-2-oxo-pyrrolidin-3-ylmethyl)-biphcnyl-4-carboxyIic acid (pyridin-4-ylmethyl)-amidc (0. lOOg, 0.186 mmol) in dichloromethane (5 mL) under argon atmosphere. Add 3-chloroperoxybenzoic acid 15 (0.055g, 0.233 mmol) and stir at room temperature for 1 hour. Concentrate under reduced pressure. Purify via flash chromatography by eluding with a gradient of 100% dichloromethane to 25% methanol /dichloromethane to obtain 0.089 g (86%) of product as a while solid: MS (m/z): 552 (M+). Example 53 20 3-(4'-(4-acetyl--piperazine-l-carbonyl)-3,5-dichloro-biphenyl-4-ylmcthyl]-l-cyclohexyI- pyrrolidin-2-one O Dissolve racemic l-cyclohexyl-3-[3,5-dichloro-4'-(piperazine-l-carbony!)-biphenyl-4-ylmethyl]-pyrrolidin-2-one(0.082g, 0.158 mmol) in dichloromethane (5 mL), 25 add 1.0 N sodium hydroxide solution (0.5 mL) and acetyl chloride (0.020 mL, 0.281 WO 2007/124337 PCT/US2007/066921 mmol). Stir the mixture, scaled, overnight at room temperature. Dilute reaction with dichloromethane (20 mL) and wash with 1.0 N sodium hydroxide (10 mL) then brine (5 mL). Collect ihe organic phase, dry over anhydrous magnesium sulfate and concentrate under reduced pressure. Purify via flash chromatography by eluding with a gradient (100%) dichloromethane to 5% ammonia methanol/95% dichloromethane to obtain 0.065 g (74%) of product as a white foam: MS (m/z): 556 (M+-). Example 54 4-[3\5'-dichloro-4-cyclohexyl-2-oxo-pyrro!Tdin-3-ylmcthyl)-biphenyl-4-carbonyl]- piperazine-1-carboxylic acid amide Q CI O 10 ° Dissolve racemic 4-[3',5'-dichloro-4'-(l-cyclohexyl-2-oxo-pyTrolidin-3-yImethyl)- biphenyl-4-carbonyI]-pipcrazine-I-carboxylic acid tert-butyl ester (0.40, 0.65mmol) in dioxane (20 mL), add 4N hydrochloric acid in dioxane (10 mL) and stir 30 min to obtain an orange residue in reaction vessel. Concentrate under vacuum, dilute residue with 15 water (10 mL) and add potassium cyanate (0.55g, 0.68 mmol). Stir the reaction at room temperature to obtain a white precipitate. Filter off solid and wash with water. Dissolve the solid in dichloromethane and concentrate under vacuum to yield a clear foam. Use resin bound solid phase acidic media (SCX) to remove residual starting material and obtain 0.168 g (46%) of product as a white solid: MS (m/z): 557 (M+). 20 Example 55 l-cyclohexyl-3-[3,5-dichloro-4'-(l,l-dioxo-llambda*6*-thiomorphoIine-4-carbonyl)- bipheny!-4-ylmethyl]-pyrrolidin-2-one O Cl WO 2007/124337 PCT/US2007/06692I Dissolve racemic 1 -cyclohexyl-3-[3,-5-dichloro-4'-(thiomorphoIine-4-carbonyl)-biphenyl-4-ylmethyi]-pyrrolidin-2-one (0.185g, 0.349 mmol) in THF (10 mL) and add meta-chloro-perbenzoic acid (0.135 g, 0.785 mmol). Add additional meta-chloro-perbenzoic acid as needed to drive reaction to completion. Dilute the reaction with ethyl 5 acetate, wash twice with 1.0 N sodium hydroxide, dry organic phase over magnesium sulfate and concentrate under reduced pressure to yield a white foam. Purify the crude material via flash chromatography by eluding with a gradient of 100% dichloromethane to 10% isopropanol/dichloromethane to obtain 0.21 g (94%) of product as a white foam: MS (m/z): 563 (M+). 10 Example 56 3'.5'-dichloro-4'-(]-cyclohexyl-2-oxo-pyrTolidin-3-ylmethyl)-biphcnyt-4-carboxylic acid (2-amino-cthyl)-amidc Dissolve racemic 3', 5*-dichloro4-ccyctohexyl-2-oxo-pyrrolidm-3-ylmethyl)-15 biphenyl-4-carboxylic acid (0.200g, 0.448mmol) in dichloromethane (5 mL) and add l.T-carbonyl-diimidazole (0.125g, 0.760 mmol). Stir the mixture under an argon atmosphere at room temperature and check reaction progress via TLC. Add tert-butyl N-(2-aminoethyl)carbamate (0.140 mL, 0.896 mmol) and continue to stir, checking progress via LC/MS. Once the starting material has been fully consumed, dilute the reaction with 20 dichloromethane (50 mL) and wash with 1.0 N sodium hydroxide (30 mL) then brine (30 mL). Collect the organic phase, dry over anhydrous magnesium sulfate and concentrate under reduced pressure. Purify via flash chromatography by eluding with gradient dichloromethane to 10% ammonia methanol/90% dichloromethane. Dissolve recovered material (0.40, 0.65mmol) in dioxanc (20 mL), add 4N hydrochloric acid -dioxanc (10 25 mL) and stir 30 min to obtain an oily residue in the reaction vessel. Concentrate the mixture under vacuum then dilute with dichloromethane (100 mL). Quench with saturated aqueous sodium bicarbonate solution (50 mL), separate the layers, dry organic phase with magnesium sulfate and concentrate to 0.155 g(7I%) of product as a white foam: MS (m/z): 490 (M+2). WO 2007/124337 PCT/US2007/066921 25 Example 57 3',5'-dichIoro-4'-( I -cyclohexyl-2-oxo-pyrrolidin-3-ylmethy!)-biphenyl-4-carboxy)ic acid piperidin-4-ylamide Dissolve racemic 3', 5'-dichloro-4'-(l-cyclohexyl-2-oxo-pyrrolidin-3-ylmethyl)-biphenyI-4-carboxylic acid (0.200g, 0.448mmol) in dichloromethane (5 mL) and add l,l*-carbonyl-diimidazole (0.125g, 0.760 mmol). Stir under argon atmosphere at room temperature and check reaction progress via TLC. Add 4-ammo-piperidine-l-carboxylic acid ten-butyl ester (0.180g, 0.90 mmol) and continue to stir until the starting material has been fully consumed. Dilute the reaction with dichloromethane (50 mL) and wash with 1.0 N sodium hydroxide (30 mL) then brine (30 mL). Collect the organic phase, dry-over anhydrous magnesium sulfate and concentrate under reduced pressure. Purify via flash chromatography by eluding with gradient (0-100%) dichloromethane to 15% ammonia methanol/85% dichloromethane. After concentrating, dissolve the 4-{[3\5'-dichloro-4'-(l-cyclohcxyl-2-oxo-pyiToIidin-3-ylmcthyl)-biphcnyl-4-carbonyl]-amino}-piperidine-1 -carboxylic acid tert-butyl ester in dioxane (20 mL), add 4N hydrochloric acid -dioxane (10 mL) and stir '/j hour to obtain an oily residue in reaction vessel. Concentrate the mixture under vacuum then dilute in dichloromethane (100 mL). Quench with saturated aqueous sodium bicarbonate solution (50 mL), dry the organic phase over magnesium sulfate and concentrate to obtain 0.195g (82%) of a yellow foam: MS (m/z): 530 (M+2). Example 58 4-[3',5'-dichloro-4'-{l-cyclohexyl-2-oxo-pyrTolidin-3-y!methyl)-biphenyl-4-carbonyl]-l- mcthyl-pipcrazin-2-onc Treat a solution of racemic l-cyclohexyI-3-[3,5-dichloro-4'-(hexahydro-pyrrolo[ 1,2-a]pyrazinc-2-carbony])-biphenyl-4-ylmethyl]-pyTTOlidin-2-on (0.245 g, 0.46 mmol) in dimethylformamide (6 mL) with 60% sodium hydride (0.037 g. 0.93 mmol) and stir for 15 minutes at room temperature under a nitrogen atmosphere. Cool the reaction to 5 0°C. treat with iodomethane (0.25 g, 1.76 mmol) and then stir at room temperature for 16 hours under a nitrogen atmosphere. Quench the reaction with IN hydrochloric acid, dilute with ethyl acetaic and wash with water. Dry the organic layer with sodium sulfate and purify by silica gel chromalography using a gradient of 0 to 10% methanol in dichloromethane to afford product. Re-crystallizc from acetone/diethyl ether to afford 81 10 mg (32%) of the title compound: MS (m/'z) 542 (M+). Preparation 59a 1 -cyclohexyl-3-[3.5-dicliloro-4'-(2,5-diaza-bicyciof2.2.1]hepiane-2-carbonyl)-biplieny]-4- ylmctliyl]-pyrrolidii)-2-onc 15 Dissolve chiral 5-[3'.5'-dichloro-4'-(]-cycloIicxyl-2-oxo-pyrrolidin-3-ylmcthyl)- biphenyl-4-carbonyi]-2,5-diaza-bicyclo[2.2.1]heptane-2-carboxylic acid ten-butyl ester (0.119 g, 0.19 mmol) in dichloromethane (3 mL), treat with trifiuoroacetic acid (I mL) and stir for I hour at room temperature. Remove (he solvent under vacuum, dissolve the residue in ethyl acetate and wash with saturated aqueous sodium bicarbonate then water. 20 Dry the organic layer with sodium sulfate, concentrate under vacuum and purify the crude product by silica gel chromatography using a gradient of 0 to 10% methanol in dichloromethane to afford 100 mg (100%) of the title compound: MS (m/z): 526 (M+). Example 60 1 -cyclohcxyl-3-[3,5-dichloro-4'-(( 1 S.4S)-5-isopropyl-2,5-diaza-bicyclo[2.2.1 Jhcptanc-2- 25 carbonyl)-biphenyl-4-ylmethy[]-pyrrolidin-2-one WO 2007/124337 PCT/US2007/U66921 Treat a solution of chiral l-cyclohexyl-3-[3,5-dich!oro-4'-(2.5-diaza-bicyclo[2.2.1 ]heptane-2-carbonyI)-biphenyl-4-ylmethyl]-pyrrolidin-2-one (0.096 g, 0.18 mmol) in methanol (3 mL) and acetone (0,105 g, 1.81 mmol) with sodium 5 cyanoborohydride (0.055 g, 0.88 mmol) and then acetic acid (0.057 g. 0.94 mmol). Stir the mixture for 3 hours at room temperature under a nitrogen atmosphere, dilute with ethyl acetate and wash with saturated sodium bicarbonate then water. Dry the organic layer with sodium sulfate and purify the crude product by silica gel chromatography using a gradient of 0 to 10% methanol in dichloromethane to afford 71 mg (68%) of the title 10 compound: MS (m/z): 568 (M +). Preparation 61a and Example 62 l-cyclohexyl-3-{3,5-dichloro-4'-[4-(2-fluoro-ethyl)-piperazine-l-carbony[]-biphenyl-4- ylmethyl} -pyrrolidin-2-one 15 Treat a solution of I -cyclohexyl-3-[3,5-dichloro-4'-(pipcrazinc-l -carbonyl)- biphenyl-4-ylmethyl]-pyrrolidin-2-one (0.67 g, 1.30 mmol) in dimelhylformamide (7 mL) with I-bromo-2-fluoroethane (0.99 g, 7.80 mmol)and heat to 55°C for 16 hours undera nitrogen atmosphere. Cool the reaction, dilute with ethyl acetate and wash with saturated aqueous sodium bicarbonate then water. Dry the organic layer with sodium sulfate and 20 purify the crude product by silica gel chromatography using a gradient of 0 to 10% methanol in dichloromethane to afford 0.47 g (64%) of the title compound in its racemic form. Separate into the enantiomers by chiral HPLC (Chiralpak AD 8 x 33 cm column, isocratic 90:10 3A cthanolracetonitrilc with 0.2% dimethylelhylaminc, 400 mL/min, 300 nM UV) to afford 286 mg of Isomer 1 (>99% ee) and 283 mg of Isomer 2 (98.9% ee): 25 MS (m/z): 560. Check the purity of each isomer using chiral HPLC (Chiralpak AD-H 4.6 WO 2007/124337 PCT/US2007/066921 x 150 mm column, isocratic 90:10 3A cthanol:acetonitrile with 0.2% dimethytethylaminc. 0.6 mL/min, 270 nM). Preparation 61a; Isomer 1 elutes ai 8.2 minutes Example 62: Isomer 2 elutes at 12.6 minutes. 5 Examples 63 and 64 I-cycIohexyl-3-f3,5-dichIoro-4'-{morpholine-4-carbony]Vbiphenyl-4-y]methyI]- pyrrolidin-2-one Separate 1.2 g of the racemic title compound (Example 4) into its enantiomers by 10 chiral HPLC (Chiralpak AD 8 x33 cm column, isocratic 90:10 3A cthanol:acetonitrilc with 0.2% dimethylethylamine, 400 mL/min, 300 nM UV) to afford 528 mg of enantiomer 1 (98.8% ee) and 560 mg of cnantiomer 2 (98.7% ee): MS (m/z): 515 (M +). Check the purity of each isomer by chiral HPLC (Chiralpak AD-H 4.6 x 150 mm column. isocratic 90:10 3A ethanol:acetonitrile with 0.2% dimethylcthylamine. 0.6 mL/min. 270 15 nM). Example 63 Isomer 1 elutes at 8.5 minutes, Example 64 Isomer 2 elutes at 11.7 minutes. Examples 65 and 66 l-cyclohexyl-3-[3,5-dichIoro-4'-(4-methyl-piperazine-l-carbonyl)-biphenyl-4-ylmcthyl]- 20 pyrrolidin-2-one hydrochloride Separate 5.5 g of racemic compound hydrochloride salt (Example 46) into the enantiomers by chiral HPLC (Chiralpak AD 8 x 33 cm column, isocratic 90:10 3A ethanokacetonitrile with 0.2% dimethylcthylamine, 400 mL/min, 300 nM UV) to afford 25 2.57 g of enantiomer i (>99%ee) and 2.85 g of enantiomer 2 (99% ee): MS (m/z): 528 WO 2007/124337 PCT/US2007/06692I (M +). Check the purity using chiral HPLC (Chiraipak AD-H 4.6 x 150 mm column, isocratic 90:10 3A ethanol.acetonitrile with 0.2% dimethylethylamine, 0.6 mL/min, 270 nM). Example 65 Isomer 1 elutes at 8.8 minutes. Example 66 Isomer 2 elutes al 13.5 minutes. Examples 67 and 68 l-cyclohcxyI-3-[3,5-dichloro-4'-(4-isopropyl-piperazine-l-carbonyl)-biphenyl-4- ylmethyl]-pyrrol idin-2-one hydrochloride Separate 8.06 g of the racemic compound hydrochloride salt into its cnantiomers by chiral HPLC (Chiraipak AD-H 4.6 x 150 mm column, isocratic 90:10 3A ethanol:acetonitrile with 0.2% dimethylethylamine, 0.6 mL/min, 270 nM UV) to afford 2.56 g of enantiomer 1 (>94% ec) and 3.6 g of enantiomer 2 (99% ee): MS (m/z): 556 (M +). Check the purity using chiral HPLC (Chiraipak AD-H 4.6 x 150 mm column, isocratic 90:10 3A ethanol:acetonitrile with 0.2% dimethylethylamine, 0.6 mL/min, 270 nM). Isomer 1 elutes al 6.6 minutes. Isomer 2 elutes at 8.9 minutes. Convert each isomer to its hydrochloric acid salt by dissolving in EtOH. treating with one equivalent of acetyl chloride and concentrating to dryness under vacuum. Example 67 is the HC1 salt of Isomer 1. Example 68 is the HCI salt of Isomer 2. Example 69 l-cyclohexyl-3-[3,5-dichloro-4'-(4-methyl-4-oxy-piperazine-l-carboiiyl)-biphenyl-4- ylmethyl}-pyrrolidm-2-one WO 2007/124337 PCT7US2G07/066921 Prepare the title compound essentially by the method of Example 51 in an 56% yield starting from racemic l-cyclohexyl-3-[3,5-dlichloro-4'-(4-methyl-piperazine-l-carbonyl)-biphenyl-4-ylmelhy!]-pyrrolidin-2-one: MS (m/z): 544 (M +). Example 70 5 l-cyclohexyl-3-[3,5-dichloro-4'-(4-methyl-4-oxy-piperazine-l-carbonyl)-biphenyl-4- ylmethyl]-pyrrolidin-2-one Prepare the title compound essentially by the method of Example 51 in a 95% yield starting from l-cyclohexyl-3-[3,5-dichloro-4'-(4-mcthyl-piperazine-t-carbonyl)- 10 biphenyl-4-ylmethyl]-pyrrolidin-2-onc(Isomer 2T Example 66): MS (m/z): 544 (M +). Example 71 l-cyclohexyl-3-[3,5-dichIoro-4'-(4-isopropyl-4-oxy-pipcrazine-l-carbonyl)-biphenyI-4- ylmethyl]-pyrrolidin-2-one o 15 Prepare the title compound essentially by the method of Example 51 starting from racemic l-cyclohexyl-3-[3,5-dichloro-4'-(4-isopropyl-piperazine-I-carbonyl)-biphenyi-4-ylmethyl]-pyrrolidin-2-one (Example 7): MS (m/z): 572 (M +). Example 72 l-cyclohexyl-3-{3,5-dichloro-4'-[4-(2,2,2-trifluoro-ethyl)-piperazine-l-carbonyl]- 20 biphenyl-4-yImethyI}-pyiTolidin-2-one WO 2007/124337 PCT/US2007/066921 Treat a solution of l-cyclohexyl-3-[3,5-dichloro-4'-(piperazine-l-carbonyI)-biphenyl-4-ylmethyl]-pyrrolidin-2-one (0.182 g, 0.35 mmol) and N,N-diisopropyI ethyl amine (0.32 g, 2.47 mmol) in THF (10 mL) with trifluoromethane sulfonic acid 2,2,2-trifluoroethyl ester (0.41 g, 1.77 mmol) and heat to reflux for 3 hours under N2. Add 5 more N.N-diisopropyl ethyl amine (0.13 g, 1.03 mmol) and trifluoromethane sulfonic acid 2.2.2-trifluoroehtyl ester (0.24 g, 1.03 mmol) and continue to heat at reflux for 2 more hours. Cool the reaction to room lemperature, dilute with ethyl acetate and wash with saturated sodium bicarbonate then water. Dry the organic layer with sodium sulfate and purify the crude product by reverse phase HPLC to afford 91 mg (43%) of the title 10 compound: MS (m/z): 596 (M+). Example 73 3- U.5-Dichloro-4'-[4-(2-fluoro-ethyl)-piperazine- l-carbonyl]-biphenyM-ylmeihyl} -cis- i -(4-hydroxy-cyclohexyI)-pyrrolidin-2-one Hydrochloride salt 15 Deprotection Procedure I: Stir a mixture of3-{3,5-dichloro-4'-[4-(2-fluoro-ethy!)-piperazine-l-carbonyI]-biphenyl-4-ylmethyl}-m-l-(4-triisopropylsilanyIoxy-cyclohexyl)-pyrrolidin-2-one (26.2 g, 35.75 mmol), 100 mL tctrahydrofuran and 71.5 mL I M tctrabutyt ammonium floridc at room temperature overnight. Concentrate under vacuum and dilute with 500 mL 20 saturated sodium bicarbonate, 500 mL water, 250 mL hexanes and 250 mL ethyl acetate. After separating the layers, wash the organic 300 mL 1:1 saturated bicarbonate:water, 250 mL water then 100 mL brine. Dry over magnesium sulfate, filter and concentrate to 20.5 g of a foam. Dissolve in a mixture of 100 mL 3:1 ethanolxthyl acetate, and treat with 45 mL IN hydrochloric acid in ether. Concentrate under vacuum and dilute with 150 mL 25 ethyl acetate. Filter the solid and dry under vacuum 1 hr. Mix with 150 mL ethyl acetate, wash, and filter to obtain a white solid. Dry for 72 hrs at 35-37°C under vacuum to recover 19.2 g (87%) of product: MS Deprotection Procedure 2: WO 2007/124337 PCT/US2007/06692I Alternatively, mix 250 mg of cis-l-[4-{iert-butyl-dimethyl-silanyloxy)-cyclohexyl]-3-[3,5-dichloro-4'-(4-isopropyl-pipera2ine-l-carbonyl)-biphenyl-4-ylmethyl]-pyrrolidin-2-one with 15 mL methanol and 0.8 mL 1 N hydrochloric acid. Then, warm to 40°C 4 hrs. Concentrate to dryness under vacuum and puriry by silica gel 5 chromatography using 10 % methanol in chloroform to recover ] 05 mg solid. Optionally, to make the HC1 salt, dissolve in 20 mL dichloromethanc and add 1 equivalent of 1 N hydrochloric acid in diethyl ether. Concentrate to dryness under vacuum: MS (m/z); 576 (M+). 10 Table 10: The Examples in Table 10 may be prepared essentially as described by the Deprotection Procedure 2 in Example 73 except for the Preparation that is deprotected is indicated in column 3. WO 2007/1243." PCT/US2007/06692I WO 2007/124337 PCTA3S2007/066921 WO 2007/124337 PCT/US2007/066921 WO 2007/124337 PCTAJS2007/066921 Examples 76, 78 and 84 are HCI salts, Example 87 (R)3-[3,5-Dich]oro-4'-(4-trifluoromethyl-piperidine-l-carbonyl)-biphenyI-4-ylmethyl]-trans-1 -(4-hydroxy-cyclohexyl)-pyrrolidin-2-onc Prepare (he title compound by using the Dcprotcction Procedure 1 as described in Example 73 and using Preparation 62 to deprotect. MS (m/z) 596 (M+). Treat a solution of 3-[3.5-dichloro-4'-(4-trifluoromethyl-piperidine-l-carbonyl)-biplienyl-4-ylmethyl]-trans-l-(4-triisopropylsilanyloxy-cyclohexyt>pyiTo\idiii-2-one (0.548 g, 0.78 mmol) in 15 mL dry tctrahydrofuran with a 1M tetrahydrofuran solution of tctrabutylammonium fluoride (1.55 ml, 1.55 mmol) and stir at room temperature for 2 hours. Quench the reaction with saturated aqueous sodium bicarbonate and extract with ethyl acetate. Wash the extract with brine, dry over magnesium sulfate, filter, and concentrate to dryness under vacuum. Purify the residue by silica gel chromatography to recover 0.448 g (97%) of the title compound: MS (m/z): 596 (M+). Table 11: The Examples in Table 11 may be prepared essentially as described by the Deproiection Procedure 2 in Example 73 except for the Preparation that is deprotected is indicated in column 3. WO 2007/124337 PCT/US2007/066921 WO 2007/124337 PCT/US2007/06G921 10 15 Examples 90 and 91 ate HCl sahs. Example 92 (R)-l-cyclohex-3-enyl-3-[3,5-dichloro-4'-(4-trifluoroniethyl-piperidine-l-carbonyl)- biphcnyl-4-ylmethyl]-pyrro!idin-2-one Dissolve letrabutylammonium fluoride trihydrale (0.436g, 1.36 mmol) in 5 ml of" aceronitrile. Add water (0.05ml. 2.72mmol) and stir for 10 minutes. Addtrans-methancsulfonic acid4-{(R)-3-t3,5-dichtoro-4'-(4-trifIuoromethyI-piperidine-l-carbonyl)-biphenyM-ylmethyl]-2-oxo-pyrrolidin-l-yl}-cyclohexyl ester (0.458 g, 0.68 mmol). Stir at 80°C for 12 hours. Quench with saturated aqueous sodium bicarbonate and extract with ethyl acetate. Wash the extract with brine. Dry the organic layer over magnesium sulfate, filter, and concentrate under vacuum. Purify by silica gel chromatography recover 0.036 g (9%) of the title compound: MS (m/z): 579 (M+). Example 93 (R)-3-(3.5-dichlorO'4'-[4-(2-fluoro-ethyl)-4-oxy-pipera2ine-l-carbonyl]-biphenyl-4- ylmethyl}-c/s-l-(4-hydroxy-cyclohexyl)-pyrrolidin-2-one Add(R)cis-l-[4-(tert-butyl-dimethyl-silanyloxy)-cycIohexyl]-3-{3,5-dichloro-4'-[4-(2-fluoro-ethyl)-piperazines'-canhonyl]-bipheny!-4-yJmeihyl}-pyrrofidin-2-one (Preparation 93) (0.193 g, 0.28 mmol) to 10 ml of dry dichloromcthanc, cool in an ice WO 2007/12-1337 PCT/US2007/066921 bath and treat with m-chloroperoxybenzoic acid (0.075 g of 77% commercial grade, 0.335 mmol). Stir foT 30 minutes and concentrate the reaction to dryness. Purify on silica with 10% methanol in chloroform to afford 0.171 g of (R)-1 -[4-(tcrt-butyl-dime(hyl-silanyloxy)-cyclohexyl]-3-j3,5-dichloro-4'-[4-(2-fluoro-ethyl)-4-oxy-5 piperazine-l-carbonyl]-biphenyl-4-ylmethyl}-pyrrolidin-2-one: MS (m/e): 707 (M+l). Dissolve the (R)-l-[4-(lcrt-butyl-dimcthyl-silanyloxy)-cyclohexyll-3-{3,5-dichloro-4'-[4-(2-fluoro-ethyl)-4-oxy-piperazine-l-carbonyl]-biphenyl-4-ylmcthyl}-pyrrolidin-2-one in 15 ml of elhanot and treat with aqueous 1 N hydrochloric acid solution. Heat the reaction overnight at 40UC then concentrate under vacuum to afford a 10 quantitative yield of the title compound: MS (m/z): 592 (M+). Example 94 (R)-3-p.5-dichloro-4'-(!, i -dioxo-1 -lambda*6*-thiomorpholine-4*carbonyl)-biphenyl-4- ylmciliyl]-.trans-{4-hydroxy-cyclohcxy!)-pyrrolidin-2-onc O 15 Dissolve (R)-irans-\-[4-(tcrt-butyl-dimcthyl-silanyloxy)-cyclohexyIJ-3-[3.5- dichIoro-4'-(thiomorpholine-4-carbonyI)-biphenyl-4-ylme(hyl]-pyrrolidin-2-one (Preparation 65) (0.366 g. 0.55 mmol) in 25 mi of methanol and cool it in an ice bath. Treat the solution with potassium peroxymonosulfate (0.694 g, 1.13 mmol) dissolved in 5 ml of water. Stir the reaction for 16 hrs at room temperature and then heat to45°C for 2 20 hrs. Remove the solvent under vacuum, dilute with water and extract twice with ethyl acetate. Wash the organic layers with brine, combine and dry over magnesium sulfate. Concentrate under vacuum to afford a quantitative yield of product: MS (m/z): 579 (M+). Example 95 (R)-3-[3,5-dichloro-41-(4-trifluoromethyI-piperidine-l-carbonyl)-biphenyI-4-ylmethyl]-i- 25 (tetrahydro-pyran-4-yl)-pyrrolidin-2-one WO 2007/124337 PCT/US2007/066921 Treat a solution of 3',5'-dichloro-4'-[(R)-2-oxo-l-(tetrahydro-pyran-4-yl) pyrrolidin-3-ylmcthyl]-biphcnyl-4-carboxylic acid (0.25 g, 0.56 mmol), 4-(trifluoromethyl)piperidine hydrochloride (0.13 g, 0.67 mmol), 1-hydroxybenzotriazole 5 (0.23 g, 0.67 mmol), and 4-methylmorpholine (0.18 mL, 1.67 mmol) in dichloromethane (10 mL) with N-(3-dimethyIaminopropyl)-N-etliylcait)odiimide hydrochloride (0.13 g,' 0.67 mmol) and stir at room temperature for 6 hr. Quench the reaction with IN hydrochloric acid and extract with ethyl acetate. Wash the organic layer with brine, dry over magnesium sulfate, and filter. Purify the crude material by silica gc! column 10 chromatography using hcxancs: ethyl acetate to afford 0.23 g (72%) of desired product: MS (m/z): 583 (M+). Table 12: The Examples in Table 12 may be prepared essentially as described in Example 95 except for me amine is replaced with (he amine as indicated. WO 2007/i 24337 PCTYUS2007/066921 WO 2007/124337 PCT/US2007/06692I Example 104 (R)-3-[3,5-dichloro^'-(4,4-difluoro-piperidine-I-carbony]).biphenyl-4-ylmethyl]-tanst5-l- (4-hydroxy -cyclohexy l)-pyTroUilin-2-one cl WO 2007/124337 PCT/US2007/066921 Prepare the title compound in 97 % yield by deprotection procedure I starling from (R)-3-[3,5-dichloro-4'-(4,4-difluoro-piperidine-1 -carbonyl)-biphenyl-4-ylmethyl]-trans-1 -C4-triisopropylsilanyloxy-cyclohexyl)-pyrrolidin-2-one. Treat a solution of (R)-3-[3,5-dichloro-4'-(4,4-difluoro-piperidine-l-carbonyl)-5 biphenyl-4'ylmethyl]-trans-l-(4-triisopropylsilany!oxy-cyclohexyl)-pyrrolidin-2-one (0.175 g, 0.24 mmol) in 15 mL dry tetrahydrofuran with a 1M tetrahydrofuran solution of tctrabutylammonium fluoride (0.7 mL 0.7 mmol) and stir at room temperature for 2 hours. Quench the reaction with saturated aqueous sodium bicarbonate and extract with ethyl acetate. Wash the extract with brine, dry over magnesium sulfate, filter, and concentrate 10 to dryness under vacuum. Purify the residue by silica gel chromatography to recover 0.097 g (71%) of the title compound: MS (m/z): 565 (M+l Table 13: The Examples in Table 13 may be prepared essentially as described in Example 3 except use 4'-(l-Cyclohexyl-2-oxo-pyrrolidin-3-ylmethyl)-3'-trifluoromethoxy-15 biphenyl-4-carboxy]ic acid (Preparation 87) and replace the amine with the amine as indicated. WO 20U7/124337 PCT/US2OO7/06692I WO 2007/124337 PCT/US2007/06692I WO 2007/124337 Table 14; The Examples in Table 14 may be prepared essentially as described in Example 3 except use 4'-(l-Cyclohcxyl-2-oxo-pyrrolidin-3-ylmethy])-3'-trifluoromcthyl-biphcnyl-4-carboxylic acid (Preparation 88) and replace ihc amine with the amine as indicated. PCT/US2007/066921 WO 2007/J 24337 PCT/US20O7/066921 Examples 116-120 are the TFA salts- because TFA is used in purification by reverse phase HPLC. Table 15: The Examples in Tabic 15 may be prepared essentially as described in Example 5 3 except use 4,-(I-Cyclohexyl-2-oxo-pyrrolidin-3-yImethyl)-3,-trifluoromethyl-biphenyl-4-carboxyIic acid (Preparation 88) and replace the amine with the amine as indicated. WO 2007/124337 PCT/US2007/066921 Example 125 (R)-3-[3,5-Dichloro-4'-(4-trifluoromethyl-piperidine-l-carbonyl)-biphenyl-4-ylmethyI]-trans-1 -(4-methoxy-cyclohexyl)-pyrrolidin-2-one 5 WO 2007/124337 PCTAJS2007/066921 Mix 3\5,-dichIoro-'-[(R)-/ra/?A--1 -(4-methoxy-cyclohexyl)-2-oxo-pyrroIidin-3-y)mcthyl]-biphcnyl-4-carboxylic acid (0.350 g, 0.74 mmc(l), l-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.216 g, 1.11 mmol), N-mcthylmorpholine (0.33 mL, 5 2.95 mmol), hydroxybenzotriazole (0.247 g, 0.74 mmol) and 4-trifluoromethyl-piperidine hydrochloride (0.226 g, 1.47 mmol) in CH2CI2 (10 mL). Stir for 12 hours at room temperature. Quench with IN HC1 and extract with ethyl acetate. Wash the extract with saturated aqueous sodium bicarbonate brine. Dry over magnesium sulfate, filter, and concentrate under vacuum. Purify by flash column chromatography to recover 0.350 g "10 P%%) of me wile compound: MS Im/z* 611 {M+). Example 126 (R)-3-[3.5-Dichloro-4'-f4,4-difluoro-piperidine-l-carbonyl)-biphenyl-4-ylmethyl]-/rani- l-(4-methoxy-cyclohexyl)-pyrrolidin-2-one 15 Prepare the title compound essentially as described in Preparation 48 starting from 3',5'-dichloro-4'-[(R)trans-4--(4-methoxy-cyclohexyl)-2-oxo-pyrro]idin-3-ylmethyl]-biphcnyl-4-carboxylic acid and 4,4-difluoropipcrazinc. MS (m/z): 580 (M+). 20 In the following section enzyme and functional assays are described which are useful for evaluating the compounds of the invention. llp-HSD type 1 enzyme assay Human I lp-HSD type 1 activity is measured by assaying NADPH production by fluorescence assay. Solid compounds are dissolved in DMSO to a concentration of 10 WO 2007/124331 PCT7US2007/06G921 mM. Twenty microliters of each are then transferred to a column of a 96-well polypropylene Nunc plate where they are further diluted 50-fold followed by subsequent two-fold titration, ten times across the plate with additional DMSO using a Tecan Genesis 200 automated system. Plates are then transferred to a Tecan Freedom 200 system with 5 an attached Tecan Temo 96-well head and an Ultra 384 plate reader. Reagents are supplied in 96-well polypropylene Nunc plates and are dispensed individually into black 96-well Molecular Devices High Efficiency assay plates (40 µL/ well capacity) in the following fashion: 9 µLwell of substrate (2.22 mM NADP, 55.5 µM Cortisol, 10 mM Tris, 0.25% Prionex, 0.1% Triton X100), 3 fiL/well of water to compound wells or 3µL 10 to control and standard wells, 6µL/well recombinant human 1 Iβ-HSD type 1 enzyme, 2 µL/well of compound dilutions. For ultimate calculation of percent inhibition, a series of wells are added that represent assay minimum and maximum: one set containing substrate with 667 MM carbenoxoione (background), and another set containing substrate and enzyme without compound (maximum signal). Final DMSO concentration is 0.5% for all 15 compounds controls and standards. Plates are then placed on a shaker by the robotic arm of the Tecan for 15 seconds before being covered and stacked for a three hour incubation period at room temperature. Upon completion of this incubation, the Tecan robotic arm removes each plate individually from the stacker and places them in position for addition of 5 µL/well of a 250 µM carbenoxoione solution to stop the enzymatic reaction. Plates 20 are then shaken once more for 15 seconds then placed into an Ultra 384 microplate reader (355EX/460EM) for detection of NADPH fluorescence. Data for example compounds in the 11-βHSDl assay are shown below: WO 2007/124337 PCT/US2007/06692J WO 2007/124337 PCT/US2007/066921 Human aortic smooth muscle cell assay Primary human aortic smooth muscle cells (AoSMC) are cultured in 5% FBS growth medium to a passage number of 6, then pelleted by centrifugation and resuspended at a density of9x10" cel!s/mL in 0.5% FBS assay medium containing 12 5 ng/mL hTNFa to induce expression of 1 lp-HSDI. Cells are seeded into 96-wcIl tissue culture assay plates at 100 uX/well (9xl03cells/well) and incubated for 48 hours ai 37'C, 5% C02- Following induction, cells are incubated for 4 hours at 37"c, 5% CO2 in assay medium containing test compounds then treated with 10 uLAvell 0f 10 u.M cortisone solubilized in assay medium, and incubated for 16 hours at 37 C, 5% CO2. Medium from 10 each well is transferred to a plate for subsequent analysis of Cortisol using a competitive fluorescence resonance time resolved immunoassay. In solution, an allophycocyanin (APC)-cortisoi conjugate and free Cortisol analytc compete for binding to a mouse anti-cortisol antibody/Europium (£u)-anti mouse lgG complex, Higher levels of free Cortisol result in dimmv?.hwig energy \ranrfer from \he Europium-lgG to the APC control complex 15 resulting in less APC fluorescence. Fluorescent intensities for Europium and APC are measured using a LJL Analyst AD. Europium and APC excitation is measured using 360 nm excitation and 615 nm and 650 nm emission filters respectively. Time resolved parameters for Europuium were 1000 us integration time \vith a 200 us delay. APC parameters are set at 150 us integration time with a 50 us delay. Fluorescent intensities 20 measured for APC are modified by dividing by the Eu fluorescence (APC/Eu). This ratio is then used to determine the unknown Cortisol concentration by interpolation using a Cortisol standard curve fitted with a 4-parameter logistic equation. These concentrations arc then used to determine compound activity by plotting concentration versus % inhibition, fitting with a 4-parameter curve and reporting the IC50. 25 Examples disclosed herein possess activity in the human aortic smooth muscle cell assay with an 1C50 of less than 300 nM. Data for example compounds in the human aortic smooth muscle cell assay are shown below: WO 2007/124337 PCT/US2007/066921 Acute In Vivo Cortisone Conversion Assay In general, compounds are dosed orally into mice, (he mice are challenged with a subcutaneous injection of cortisone at a set limepoint after compound injection, and the 5 blood of each animal is collected some time later. Separated serum is then isolated and analyzed for levels of cortisone and Cortisol by LC-MS/MS. followed by calculation of WO 2007/124337 PCT/US2007/066921 mean Cortisol and percent inhibition of each dosing group- Specifically, male C57BL/6 mice are obtained from Harlan Spraguc Dawley at average weight of 25 grams. Exact weights are taken upon arrival and the mice randomized into groups of similar weights. Compounds are prepared in 1% w-w HEC, 0.25% w-w polysorbale 80, 0.05% w-w Dow 5 Corning antifoam #1510-US at various doses based on assumed average weight of 25 grams. Compounds are dosed orally, 200 µ1 per animal, followed by a subcutaneous dose, 200µl per animal, of 30 mg/kg cortisone at 1 to 24 hours post compound dose. At 10 minutes post cortisone challenge, each animal is euthanized for 1 minute in a C02 chamber, followed by blood collection via cardiac puncture into scrum separator tubes. 10 Once fully clotted, rubes are spun at 2500 x g, 4°C for 15 minutes, the serum transferred to wells of 96-well plates (Coming Inc, Costar #4410, cluster tubes, 1.2 ml. polypropylene), and the plates are frozen at -20°C until analysis by LC-MS/MS. For analysis, serum samples arc thawed and the proteins are precipitated by the addition of acetonrtrile containing d4-Cortisol "internal standard. Samples are vortex mixed and ] 5 centrifuged. The supernatant is removed and dried under a stream of warm nitrogen. Extracts are reconstituted in methanol/water (1:1) and injected onto the LC-MS/MS system. The levels of cortisone and Cortisol are assayed t?y selective reaction monitoring mode following positive ACPI ionization on a triple quadrupolc mass spectrophotometer. Data for example compounds in the acute in vivo cortisone conversion assay arc 20 shown below. WO 2007/124337 PCT/US2007/066921 Pharmaceutically acceptable salts and common methodology for preparing them are well known in the art. See. e.g., P. Stahl, ei at, HANDBOOK OF PHARMACEUTICAL SALTS: PROPERTIES, SELECTION AND USE, (VCHA/Wiley-VCH, 2002); S.M. Berge, et al.,. "Pharmaceutical Salts," Journal of 5 Pharmaceutical Sciences, Vol. 66, No. 1, January 1977. The compounds of the present invention are preferably formulated as pharmaceutical compositions administered by a variety of routes. Most preferably, such compositions are for oral administration. Such pharmaceutical compositions and processes for preparing same are well known in the art. See, e.g., REMINGTON: THE SCIENCE AND PRACTICE OF PHARMACY (A. 10 Gennaro, et a!., eds., 19 cd.. Mack Publishing Co., 1995). The particular dosage of a compound of formula (I) or a pharmaceutically acceptable salt thereof required to constitute an effective amount according to this invention will depend upon the particular circumstances of the conditions to be treated. Considerations such as dosage, route of administration, and frequency of dosing are best 15 decided by the attending physician. Generally, accepted and effective dose rdnges for oral or parenteral administration will be from about 0.1 mg/kg/day to about 10 mg/kg/day which translates into about 6 mg to 600 mg, and more typically between 30 mg and 200 mg for human patients. Such dosages will be administered to a patient in need of treatment from one to three times each day or as often as needed to effectively treat a 20 disease selected from those described herein. One skilled in the art of preparing formulations can readily select the proper form and mode of administration depending upon the particular characteristics of the compound selected, the disorder or condition to be treated, the stage of the disorder or condition, and other relevant circumstances. (Remington's Pharmaceutical Sciences, 18th 25 Edition, Mack Publishing Co. (1990)). The compounds claimed herein can be administered by a variety of routes. In effecting treatment of a patient afflicted with or at risk of developing the disorders described herein, a compound of formula (I) or a pharmaceutically acceptable salt thereof can be administered in any form or mode that makes the compound bioavailable in an effective amount, including oral and parenteral 30 routes. For example, the active compounds can be administered rectally, orally, by inhalation, or by the subcutaneous, intramuscular, intravenous, transdermal, intranasal, rectal, occular, topical, sublingual, buccal, or other routes. Oral administration may be WO 2007/124337 PCT/US2007/066921 preferred for treatment of the disorders described herein. In those instances where oral administration is impossible or not preferred, the composition may be made available in a form suitable for parenteral administration, e.g., intravenous, intraperitoneal or intramuscular. WE CLAIM: 1. A compound structurally represented by the formula: ,2 is represents ihc point of attachment lo the R position: -11, -halogen. -CH3 (optionally substituted with I to 3 halogens), or -O-CII3 (optionally substituted with 1 to 3 halogens): -halogen, -CH3 (oplionally substituted with I lo 3 halogens), or -O-CH3; (optionally substituted vvilh 1 to 3 halogens); R is -M or -halogen; R5is the point of attachment to the R3 position; Rh is wherein n is 0. 1, or 2. and wherein when n is 0. then "(CH2) n" is a bond: wherein m is 1 or 2; s -H, -(C|-C3)alkyl(optionai]y substituted with 1 to 3 halogens). -(C|-C3)alkyl-0-R2° . -(C1C3)alkyl-pyrrolidinyl, phenyl. -HETl'. -HEX2. -CH2-phcnyl. -CH2-HET', -CH2-HHT2, -(C|-Q)alkyi-N(R2(,)(R2n),-(C,-C3)alkyl-Nl(0-)(Cn;1)2. -(C1-C3)alkyl-C(0)N(R4I)(R41), -CH(C(0)01I)(CH2OR20). -CH(C(O)OH)(CH2N(R20)(R20)),-(Ci-C3)alkyl-C(O)O-R20. of attachment to the position indicated by R'; XI7254 KP and OUS amendments DLW 9.8.08 H^ point ofattachmcnt to the position indicated by I HIT2 IU-Tis R?is R8 is point ofattachmcnt to the position indicated by HKT~: -H. -(C1-C3)alkyl(oplionally substituted with 1 to 3 halogens), or -(C1-C3)alkyl-O-R20; -II, -OH -(C1-C6l)alkyI(optionally substituted wilh I to 3 halogens). -(C1-C3)alkyl-0-R20, -C(0)-(C1|-C4)alkyl(oplionally substituted with I to 3 halogens), -C(0)0-(C1-C4)alkyl(optionally subslilulcd with 1 lo 3 halogens), or -C(O)-N(R20)(R20): R9 is -I I,--halogcn, -CH3 (optionally substituted with 1 lo 3 halogens), or -O-CH3 (optionally subslilulcd with 1 to 3 halogens); Rl(l is independently al each occurrence -II, or -halogen; R11 is independently al each occurrence -H. -CH3or--CH2-CII.;; R2()is independently al each occurrence -H, or -(C1-C3)alkyl(optionally substituted with 1 to 3 halogens); R21 is independently at each occurrence -H, -halogen, or -(C1-G4)alkyl(oplionally substituted with 1 to 3 halogens); R22 is independently al each occurrence -1-L or -(C1-C6)alkyl(optionally subslilulcd with I to 3 halogens): R23 is independently al each occurrence -H, -(C1-C2)alkyl. or -C(0)0-(C1-C4,)alkyI; R31 is independently at each occurrence -H, -halogen, or -(C1-C6)alkyl(optionally substituted with 1 lo 3 halogens); R41is independently at each occurrence -H. -halogen, or -(C1-C6)alkyl(oplionaily substituted with 1 to 3 halogens); and R42 is independently at each occurrence -H. or -(C1-C6))alkyl(oplionally substituted with 1 to 3 halogens); provided the compound is not {[3'-Chloro-4'-(l -cyclohcxyl-2-oxo-pyrrolidin-3-ylmcthyl)-biphenyl-4-carbonyl]-amino}-accticacid, 4-{|3'-Chloro-4'-(l-cyclohexyl-2-oxo-pyrro!idin-3-ylmelhyl)-biphenyl-4-carbonyl|-amino}-butyric acid. 3,-Chloro-4'-(l-cyclohexyl-2-oxo-pyrrolidin-3-ylmclhyl)-biphcnyl-4-carboxylic acid piperidin-4-ylamidc, or 3-|3-Chloro-4'-(4-mcthyl-pipcray.ine-l -carbonyl)-biphcnyl-4-ylmcthyl]-lrcyclohcxyl-pyrrolidin-2-onc; or a pharmaceutical ly acceptable salt thereof. X17254 HP and OUS amendments DIw 9.8.08 „ , 2. A compound of Claim 1 wherein R is , or a pharmaceutically acceptable salt thereof. 3. A compound of Claim 1 or Claim 2 wherein R and IV arc chlorine, or a pharmaceutically' acceptable salt thereof. 4. A compound as claimed by any one of Claims 1 through 3 wherein R1 is hydrogen, or a pharmaceutically acceptable salt thereof. 5. A compound as claimed by any one of Claims 1 through 4 wherein R1 is . or a pharmaceutically acceptable salt thereof 6. A compound as claimed by any one of Claims 1 through 4 wherein R is . or a pharmaceutically acceptable salt thereof. 7. A compound as claimed by any one of Claims 1 through 4 wherein R1 or a pharmaceutically acceptable salt (hereof 8. A compound as claimed by any one of Claims 1 through 7 wherein \V is XI7254 HP and OUS amendments DLW 9.8.08 R's is -H, -(C1-C6)alkyl(optionally substituted with 1 to 3 halogens). -(C2-C3)alkyl-0-R2°, -C(0)-(C1-C4,)alkyI, -C(0)0-(C1,-C4,)alkyf, or -C(O)-N(R20)(R20); R9is -H,-halogen, -CH3 (optionally substituted with 1 to 3 halogens), or -O-CH3 (optionally substituted with 1 to 3 halogens); R is independently at each oceurrencc -11 or halogen: R"n is independently al each occurrence -I I. or -(C1|-C3)alkyl(oplionally substituted with 1 to 3 halogens); R21 is independently at each occurrence -II, -halogen, or -(C1-C3)alkyl: R22, is independently at each occurrence -H or -(C|-C3)alkyl(oplionally substituted with 1 to 3 halogens); and R23is independently at each occurrence -H. -(C1-C.3)alkyl. or-C(0)0-(C1,-C4)alkyl: or a pharmaceutically acceptable salt thereof. 9. A compound as claimed by any one of Claims 1 through 8 wherein \V is R is -(C1-C4)alkyl(oplionaily substituted with I to 3 halogens); R9is -M,-halogcn, -CH3 (optionally substituted with 1 to 3 halogens: and R is independently at each occurrence -H or—halogen; or a pharmaceutically acceptable salt thereof. X17254 HP and OUS amendments DLW 9.8.08 ., , 10. A compound as claimed by any one of Claims J through 9 wherein R5 wherein R is -(C1-C3)alkyl (optionally substituted with 1 to 3 halogens), or a pharmaceutical^ acceptable salt thereof. 11. A compound as claimed by any one of Claims 1 through 9 wherein R6 , or a pharmaceutically acceptable salt thereof 12. A compound as claimed by any one of Claims 1 through 9 wherein R7 is or a pharmaceutical!)' acceptable salt thereof. 13. A compound as claimed by any one ol Claims 1 through 9 wherein R5 is or a pharmaceutical^ acceptable salt thereof. 14. A compound of Claim I that is l-cyclohexyl-3-{3.5-dichloro-4'-|4-(2-fluoro-cthyl)-pipcra/.inc-l-carbonyl]-biphenyl-4-ylmethyl}-pyrrolidin-2-onc or a pharmaceutical ly acceptable salt thereof. 15. A compound of Claim 1 that is (R)-3-|3,5-dichloro-4'-(4-lrinuoromethyl-piperidinc-l-carbonyl)-biphcnyl-4-ylmcthyl]-l-(tctrahydro-pyran-4-yl)-pyrrolidin-2-onc or a pharmaceutical^ acceptable salt thereof. 16. A compound of Claim 1 selected from the group consisting of: 3',5'-dichloro-4'-(l-cyclohcxyl-2-oxo-pyrrolidin-3-ylmclhyl)-3-fluoro~biphcnyl-4-carboxylic acid amide; l-Cyclohexyl-3-{3.5-dichloro-4,-J4-(2-hydroxy-cthyl)-pipcra/.inc-l-carbonyl|-biphcnyl-4-ylmclhyl}-pyrrolidin-2-onc; l-cyclohcxyl-3-|3.5-dichloro-4;-(pipendinc-l-carbonyl)-biphcnyl-4-ylmclhyl)-pyrrolidin-2-onc; X17254 KP and OUS amendments DI,W 9.8.08 . l-Cyclohcxyl-3-|335-dichloro-4'-(morpholinc-4-carbonyl)-biphenyi-4-ylmethyl|- pyrrolidin-2-one; 3'75'-Dichloro-4,-(]-cyciohcxyl-2-oxo-pyrrolidin-3-yImclhyl)-biphcnyl-4- carboxylic acid bis-(2-hydroxy-clhyl)-amide; l-Cyclohcxyl-3-[3,5-dichloro-4'-(4-isopropyl-pipcrazinc-l-carbonyl)-biphcnyl-4- ylmethy]]-pyrrolidin-2-onc; 3,,5'-Dichloro-4,-(l-cyclohexyl-2-oxo-pyrrolidin-3-ylmcthyl)-biphcnyl-4- carboxylic acid (2-dimclhylamino-cthyl)-amidc; 3',5'-Dichloro-4'-(l-cyclohexyl-2-oxo-pyrrolidin-3-ylmethyl)-biphcnyl-4- carboxylic acid (2-dimethylamino-ethyl)-methyl-amidc; l-CycIohexyl-3-j3,5-dichloro-4'-(4-trifluoromethyI-piperidine-l-carbonyI)- biphcnyl-4-ylmclhyl]-pyrrolidin-2-onc; l-CycloliexylO-|3.5-dichloro-4'-(4-hydroxy-piperidinc-1-carbonyl)-biphcnyi-4- ylmclhyl [-pyrrol idin-2-onc; 3'T5'-l)ichloro-4,-(l-cyclohexyl-2-oxo-pyrrolidin-3-y!mcthyl)-biphenyi-4- carboxylic acid (2-hydroxy-elhyl)-mclhyl-amidc; l-CycIohexyl-3-|'3,5-dichIoro-4r-(thiomorpholine-4-carbonyl)-biphcnyl-4- ylmelhyi ]-pyrrolidin-2-one; 3',5'-Dichloro-4'-(l-cyc]ohexyl-2-oxo-py!Tolidin-3-ylmclhyl)-biphcnyi-4- carboxylic acid (2.2,2-trifluoro-ethyl)-amide; l-Cyclohcxy]-3-{3,5-dichloro-4,-[4-(2-fluoro-ethyl)-pipcra/.inc-l-carbonyl|- biphcnyl-4-ylmethyl}-pyrrolidin-2-one; 3',5'-Oichloro-4'-(l-cyclohexyl-2-oxo-pyrrolidm-3-ylmcthyl)-b\pbcnyl-4- carboxylic acid mcthylamide; 3',5'-Oichloro-4'-(!-cyclohexyl-2-oxo-pyrrolidin-3-ylmelbyl)-biphcnyl-4- carboxylic acid dimelhylamide; 3'-5'-I)ichloio-4'-(]-cyclohexyl-2-oxo-pyrrolidin-3-ylmclhyI)-biphcnyI-4- carboxylic acid isopropylamidc; 3,,5'-I)ichloro-4'-(l-cyclohcxyl-2-oxo-pyrroIidin-3-ylmclhyi)-biphcnyl-4- carboxylic acid cthylamide; XI7254 M? and OUS amendmcnls DLW 9.8.08 3'?5'-Dichloro-4'-(1-cyclohexyl-2-oxo-pyrrolidin-3-ylmcthyI)-biphcnyI-4- carboxylic acid (pyridin-4-ylmethyl)-amide; 3,.5'-Oichloro-4'-(1-cyclohexyl)-oxo-pyrrolidin-P-ylmcthylJ-biphenyl)-4- carboxylic acid cyclopropylamidc; 3',5,-Dichloro-4,-(I-cyciohexyl-2-oxo-pyrroiidin-3-yImclhyI)-biphcny]-4- carboxylic acid cyclobutylamide; 3-[ 4'-(A/.elidine-1-carbonyI)-3,5-dichioro-biphenyi-4-ylmcthyl |-1-cyclohcxy 1- pyrrolidin-2-onc; 3';5'-Dichloro-4'-(l-cyclohexyI-2-oxo-pyrroIidin-3-ylmcthyl)-biphcnyl-4- carboxylic acid bis-(2-hydroxy-ethyl)-amide; l-[3'.5,-Dich]oro-4'-(l-cyclohcxyl-2-oxo-pyiTolidin-3-ylmethyl)-biphcnyI-4- carbony]]-piperidin-4-one; 3^5'-Dichloro-4-(l-cyclolecxyl-2-oxo-pyrrolidin-3-ylmethyl)-biphcnvl-4- carboxylic acid (4-amino-cyclohcxyl)-amidc: 4-[3,,5,-Dichloro-4'-(l-cyclohexyl-2-oxo-pyrrolidin-3-ylmethyl)-biphcnyl-4- carbonyi|-pipcrazine-]-carboxylic acid dimcthylamidc; ]-Cyclohcxy]-3-i3,5-dichloro-4,-(hexahydro-pyrrolol 1.2 a|pyra/.ine-2-carbonyl)- biphcnyl-4-y]mcthyl]-pyrrolidin-2-onc; I -Cyclohcxyl-3-| 3,5-dichIoro-4'-(hexahydro-pyra7.ino| 2.1 -cj| 1,4|oxa/.inc-8- carbonyl)-biphcnyl-4-ylmethyI]-pyrrolidin-2-onc: l-CycIohexyl-3-[3,5-dichloro-4'-(l,4,67-letrahydro-imida/,o|4,5"C|pyridinc-5- carbonyl)-biphenyl-4-ylmelhyi]-pyrrolidin-2-one; l-Cyclohexyl-3-[3,5-dichloro-4'-(bexahydro-pyrrolidin-,2-a|pyrazmc-2-carbonyl)- biphcnyl-4-ylmethyl]-pyrrolidin-2-one; 5-3,5-'-Dichloro-4'-(l-cyclohexyl^-oxo-pyrrolidin^-ylmcthylJ-biphcnyl-4-carbonyr|-2,5-diaza-bicyclo[2.2.1]heptane-2-carboxylic acid Icrt-bulyl ester: 1 -Cyclohexyi-3-| 3,5-dichIoro-4'-(pyrrolidine-1 -carbonyl)-biphcnyl-4-ylmcthyl |-pyrrolidin-2-onc: {[3,.5'-dichloro-4'-(l-cyclohexyl-2-oxo-pyrrolidin-3-ylmclhyl)-biphcnyl-4' carbonyl(-amino}-acclic acid; X17254 HP and OUS amendments DLW 9.8.08 (S)-2-{|31,5'-Dichloro-4'-(l-cycIohexyl-2-oxo-pyrro]idin-3-ylmcthyi)-biphenyl-4- carbonyl]-amino}-3-hydroxy-propionic acid; (R)-2-{ 13l,5'-Oichloro-4'-( 1 -cyclohcxyl-2-oxo-pyrrolidin-3-ylmelhyl)-bipheny 1-4- carbonyl|-amino}-3-hydroxy-propionic acid; 2-{|3',5'-Dichloro-4'-(l-cyclohcxyl-2-oxo-pyrrolidin-3-ylmcthy])-biphcnyl-4- carbonyl|-amino}-3-dimelhylamino-propionic acid; 3',5'-Dichloro-4'-(l-cyc]ohexyl-2-oxo-pyrrolidin-3-ylmcthyl)-biphcnyl-4- carboxylic acid mcthyl-(lH-lelrazol-5-yI)-amide; 3-[ 4'-(4-tcrl-Buly l-pipcrazine-1-carbony l)-3,5-dichloro-biphcny 1-4-ylmcthy 11-1- cyclohexyl-pyrrolidin-2-one; l-Cyciohcxyl-3-[3,5-dichloro-4'-(3-trifIuoromethyl-5,6-dihydro-8H- 11.2,4[riazolo|4,3-a]pyrazine-7-carbonyl)-biphenyl-4-ylmelhyl]-pyrrolidin-2-onc: l-cyclohcxyl-3-|3.5-dichloro-4'-(4-mclhyi-pipcra/.inc-l -carbonyl )-biphenyl-4- ylmclhy] |-pynolidin-2-onc; 3',5'-dichioro-4'-(l-cyclohexyl-2-oxo-pyrrolidin-3-ylmelhyl)-biphcnyi-4- carboxylic acid azelidin-3-ylamidc; 3'.5'-dichloro-4'-(l-cyclohcxyl-2-oxo-pyrrolidin-3-yImcthy!)-biphcnyl-4- carboxylic acid (3-amino-cyclohcxyl)-amidc; l-cyclohcxyl-3-|3,5-dichloro-4r-(piperazine-l-carbonyl)-biphcnyl-4-ylmeihyl|- . pyrrolidin-2-onc; 3',5'-diehloro-4'-(l-cyclohexyl-2-oxo-pyrrolidin-3-ylmelhy!)-biphcnyl-4- carboxylic acid (4-amino-cyclobexyl)-amide; 3\5'-dichloro-4'-(I-cyclohexyl-2-oxo-pyrrolidin-3-ylmcthyl)-biphenyl-4- carboxylic acid (2-dimethylamino-ethyl)-amide N-oxidc; 3',5'-dichloro-4'-(l-cyclohexyl-2-oxo-pyrrolidin-3-y!mclhyl)-biphciiyl-4- carboxylic acid (l-oxy-pyridin-4-ylmethyl)-amidc: 3-j4'-(4-acelyl-pipcrazine-l-carbonyl)-3,5-dichloro-biphenyI-4-ylmcthyl|-]- cyclohcxyl-pyrrolidin-2-one; 4-[3'.5'-dichloro-4'-(l-cyclohexyl-2-oxo-pyrrolidin-3-y!mcthyI)-biphcnyi-4- carbonyl|-pipcra/.inc-l-carboxylic acid amide: X17254 HP and OUS amendments DLW -9.8.08 l-cyclohcxyl-3-|3,5-dichloro-4'-(l,l-dioxo-llambda*6*-thiomorphoIinc-4- carbonyl)-biphcnyl-4-ylmcthyl]-pyrrolidin-2-onc; 3,,5'-dichloro-4'-(l-cyc]ohcxyl-2-oxo-pyrrolidin-3-yImclhyl)-biphcnyl-4- carboxylic acid (2-amino-ethyl)-amide; 3',5'-dichloro-4'-(l-cyclohexyl-2-oxo-pyrroIidin-3-ylmclhyl)-biphenyl-4- carboxyltc acid pipcridin-4-ylamide; 4-|"3,,5'-dichloro-4l-(l-cyclohexyl-2-oxo-pyrrolidin-3-ylmethyl)-biphcnyl-4- carbonylj-l-mcthyl-pipcvazin-2-onc; l-cyclohcxyl-3-[3,5-dichloro-4'-((lS,4S)-5-isopropyl-2,5-dia/a- bicyclo| 2.2.1 |hcptane-2-carbonyl)-biphenyl-4-ylmcthyl]-pyrrolidin-2-onc; l-cycIohcxyl-3-{3,5-dichloro-4'-[4-(2-fluoro-cthyl)-pipcrazinc-l-carbonyl|- biphcnyl-4-ylmcthyl}-pyrrolidin-2-one; ]-cyclohexyl-3-|3,5-dic]iloro-4'-(morpholino-4-carbonyl)-biphcnyl-4-y]meihyl|- pyrroIidin-2-onc; l-cyclohexyl-3-|3,5-dichloro-4'-C4-methyl-piperazine-l-carbonyl)-biphcnyl-4- ylmcthyl |-pyrrolidin-2-onc; I -cyclohexyl-3-| 3,5-dichloro-4'-(4-isopropyl-pipera/ine-1 -carbonyl)-biphcnyl-4- ylmcihyl |-pyrrolidin-2-onc; 1 -cyclohcxyl-3-| 3,5-dichloro-4'-(4-melhyl-4-oxy-pipera/.inc-1 -carbony I)- biphcnyl-4-yImelhyl|-pyrrolidin-2-onc; l-cyclohexyl-3-|'3,5-dichloro-4'-(4-meVhy!-4-oxy-pipcrayjnc-l-carbony 1)- biphcnyl-4-ylmcthyl]-pyrrolidin-2-one; I -cyclohcxyl-3-[3,5-dichloro-4'-(4-isopropyl-4-oxy-pipcra/inc-l -carbony 1)- biphenyl-4-ylmethyl]-pyrrolidin-2-one; l-cyclohexyl-3-{3,5-dichloro-4'-[4-(232f2-trifluoro-ethyl)-pipcrazinc-i -carbony! |- biphcnyI-4-ylmcthyl}-pyrrolidin-2-one; 3-{3,5-I)ichloro-4'-|4-(2-nuoro-ethyl)-piperazine-l-carbonyl|-biphcnyl-4- ylmclhyl) -cis-1 -(4-hydroxy-cyclohcxyl)-pyrrolidin-2-onc; 3-|3)5-Dichloro-4'-(1,1-dioxo-l-lambda*6*-thiomorpholinc-4-carbonyl)- biphcnyl-4-ylmcthyl|-cis-I-(4-hydroxy-cyclohcxy])-pyrrolidin-2-onc; XI7254 IT and OUS amcndmcnls DLW 9.8.08 (R)-3-|3,5-Dichloro-4'-(morpho]ine-4-carbonyl)-biphcnyl-4-ylmclhyl[-cis-l-(4- hydroxy-cyclohcxyI)-pyrrolidin-2-one; (R)-3-{3,5-Dichioro-4'-[4-(2-fluoro-ethyl)-pipcrazinc-1-carbony!|-biphcnyl-4- ylmcthy!}-c/.v-l-(4-hydroxy-cyclohexyl)-pyrrolidin-2-onc; (R)-3-|3,5-Dichloro-4,-(4-trinuoromcthyl-pipcridinc-i-carbonyl)-biphcnyl-4- ylmcthyl]-fi.v-l-(4-hydroxy-cyclohexyl)-pyrrolidin-2-onc; (R)-3- [4,-(4-tcrt-Iiutyi-piperazine-l-carbonyl)-3,5-dichloro-biphcnyl-4- ylmclhyl|-cis-l-(4-hydroxy-cycIohexyl)-pyrrolidin-2-onc; (R)-3-|3,5-DichIoro-4'-(| l,4]oxazcpane-4-carbonyl)-biphcnyl-4-ylmclhyl|-cis-]- (4-hydroxy-cyclohexyI)-pyrroIidin-2-onc; (R)-3-|3,5-Dichloro-4;-(4,4-difluoro-piperidine-l-carbonyl)-biphcnyl-4- ylmcthyll-c7.v-l-(4-hydroxy-cyclohexyl)-pyrrolidin-2-onc; (R)-3-| 3.5-1 )ichloro-4'-(3.3-difluoio-pyrrolidinc-l -carbonyl )-biphcny 1-4- ylmclhyi |-cis-l-f4-hydroxy-cyclohcxyl)-pyrrolidin-2-onc: (R)-3-|3.5-I)ichloro-4:-(4-methoxy-pipcridine-l-carbonyl)-biphenyl-4-ylmclhylj- cis-1 -(4-hydroxy-cyclohcxyl)-pyrrolidin-2-onc; (R)-3-|3.5-Oichloro-4'-(2.6-c/.v-dimcthy]-morpho]inc-4-carbonyl)-biphcnyl-4- yImethyi|-cis-l-(4-hydroxy-cyclohcxyl)-pyrrolidin-2-onc; (R)-3-|3.5-Dichloro-4,-(piperazine-]-carbonyl)-biphenyI-4-ylmcthyl-cisv-I-(4- hydroxy-cyclohcxy])-pyrrolidin-2-onc; (R)-3- {3.5-Dichloro-4'-| 4-(2,2,2-trifluoro-ethy l)-pipcrazinc-1 -carbonyl j-biphcnyl- 4-y!mcthyl}-cis-l-(4-hydroxy-cyclohcxyl)-pyrro!idin-2-onc; (R)-3-(3.5-Dichloro-4'-(2-oxa-5-aza-bicyclol2.2.r|hcptanc-5-carbony])-biphcnyl- 4-ylmethyl]-c/.v-l-(4-hydroxy-cyclohexyl)-pyrrolidin-2-one; (R)-3-|3.5-Dichioro-4'-(4-trifluoromethyl-piperidine-l-carbonyl)-biphcnyl-4- ylmcthyl|-trans-l-(4-hydroxy-cyclohcxyl)-pyrrolidin-2-onc; (R)-3-{ 3.5-l)ichloro-4'-|4-(2.2.2-trifluoro-ethyl)-pipcrazinc-l -carbonyl[-biphcny I- 4-ylmcthy]}-/rt/m-l-(4-hydroxy-cyclohexyl)-pyrrolidin-2-onc: (R)-3-|3.5-l)ichloro-4'-(morpholine-4-carbonyl)-biphcnyl-4-ylmcthyl|-trans.-1- (4-hydroxy-cyclohcxyl)-pyrroIidin-2-onc: XI7254 1-P and OUS amendmcnls DLW 9.8.08 (R)-3-{3.5-Dichloro-4'-|4-(2-fluoro-ethyl)-pipcrazinc-l-carbonyI|-biphcny]-4- ylincthyl}-trans--l-(4-hydroxy-cyclohexyI)-pyrrolidin-2-onc; (R)-3-|4'-(4-tcrt-Butyi-piperazine-l-carbonyI)-3.5-dichloro-biphcnyl-4- y!mcthyI|-trans-]-(4-hydroxy-cyclohexyI)-pyrroiidin-2-onc; (R)-l-cyclohcx-3-enyl-3-[3,5-dichloro-4'-(4-trinuoromcthyl-pipcridinc-l- carbonyl)-biphenyl-4-yImethyl]-pyrrolidin-2-one; (r^)-3-{3,5-dichloro-4'-|4-(2-fluoro-elhyl)-4-oxy-pipcra/inc-l-carbonyl] biphcnyl-4-yimcthyl}-c/".v-l-(4-hydroxy-cyclohexyI)-pyrro]idin-2-onc; (R)-3-|3,5-dichloro-4'-(l,l-dioxo-l-Iambda*6*-thiomorphoIine-4-carbonyl)- biphcnyl-4-ylmcthyI]-trans.v-l-(4-hydroxy-cyclohexyl)-pyrrolidin-2-one; (R)-3-)3,5-dich]oro-4'-(4-trinuoromethyl-piperidine-]-carbonyl)-biphcnyl-4- ylmcthy]|-l-(tctrahydro-pyran-4-yl)-pyrrolidin-2~one; (R)-3-j3,5-!)ichIon)-4'-(4-mcthyI-pipcra/inc-l-carbonyl)-biphcnyl-4-ylmcthvl|-l (iclrahydro-pyran-4-yl)-pyrrolidin-2-onc: (R)-3-|3,5-I)ichloro-4,-(4-isopropyl-piperazinc-l-carbonyl)-biphcnyI-4-ylmclhyl| l-(tctrahydro-pyran-4-y!)-pyrrolidin-2-one; (R)-3-|3.5-Dichloro~4'-(morpholinc-4-carbonyl)-biphcnyI-4-ylmcthylj-l- (lctrahydro-pyran-4-yl)-pyrrolidin-2-one; (R)-3-j3,5-Dichloro-4'-(l3]-dioxo-116-thiomorpholinc-4-carbonyl)-biphcnyI-4- ylmelhy]|-I-(tetrahydro-pyran-4-yl)-pyrrolidin-2~one; (R)-3-{3.5-Dichloro-4'-[4-(2-fluoro-clhyl)-piperazine-]-carbonyl|-biphcriyl-4- ylmethyl}-l-(telrahydro-pyran-4-yl)-pyrrolidin-2-onc; (R)-3-{3.5-Dicbloro-4'-|4-(2,2,24nfluoro-elhyl)-pipera/ine-l-carbonyI|-biphcnyl 4-ylmcthyl} -1 -(letrahydro-pyran-4-yl)-pyrrolidin-2-onc; (R)-3-|4,-(4-Adamantan-2-yl-pipcrazine-l-carbonyI)-3,5-dichloro-biphcnyl-4- ylmclhyl]-1 -(lclrahydro-pyran-4-yl)-pyrrolidin-2-one; (R)-3-| 3,5-l)ichloro-4'-(4,4-diiluoro-piperidine-!-carbonyl)-biphcnyl-4- ylnicthylj-l-(lclrahydro-pyran-4-yI)-pyrrolidin-2-onc; (R)-3-|3.5-dichioro-4'-(4.4-dinuoro-piperidine-l-carbonyl)-biphcny]-4-ylmclhyl[ trans-l-(4-hydroxy-cyclohexyl)-pyrroIidin-2-onc: XI7254 HP and OUS amendments DLW 9.8.08 l-Cyclohcxyl-3-|41-(4-melhyl-pipera'/ine-l-carbony])-3-trinuoromc(hoxy- biphcnyl-4-ylmclhyl]-pyrrolidin-2-onc; l-Cyclohcxyl-3-|4'-(4-isopropy]-pipcrazinc-l-carbonyl)-3-trilluoromelhoxy- biphenyl-4-ylmelhyi|-pyrrolidin-2-onc; l-Cyclohexy]-3-|4'-(morpholine-4-carbonyl)-3-trinuoromelhoxy-biphcnyl-4- ylmcthyl j-pyrrolidin-2-onc; l-Cyclohexyl-3-|3~trif]uoromclhoxy-4'-(4-trifluoromcthyl-pipcridinc-l-carbonyl)- biphcnyl-4-ylmclhyr|-pyrrolidin-2-onc; 1 -Cyclohcxy 1—3—J 4'-( 1,1 -dioxo-1 i6-lhiomorpholine-4-carbony l)-3- trifluoromcthoxy-biphenyl-4-ylmethyl]-pyrrolidin-2-one; 3-| 4'-(4-tert-Buty 1-piperazinc-1 -carbony l)-3-trifluoromcthoxy-biphcny 1-4- ylmethyl |-1 -cyclohexyl-pyrrolidin-2-one; 1 -Cyclohcxy l-3-| 4'-(4.4-difluoro-pipcridinc-l -carbony l )-3-lii lluoromcihoxy- biphcnyl-4-ylmethyl|-pyrrolidin-2-onc; 1 -Cyclohcxy 1-3- {4'-| 4-(2-fluoro-elhyl)-piperazine- l-carbonyl |-3- lrifluoromclhoxy-biphenyl-4-ylmethyl}-pyrrolidin-2-onc; 1-Cyclohcxy l-3-{4'-|4-(2.2,2-lrifluoro-clhyl)-pipcrazinc-1-carbonyl |-3- lrinuoromclhoxy-biphenyl-4-ylmethylj-pyrrolidin-2-onc; 3-|4'-(4-Adamantan-2-yl-piperazine-l-carbony l)-3-(riiluoromelhoxy-biphcny 1-4- ylrncthy!|-l-cyclohexyl-pyrrolidin-2-one; 1-Cyclohcxy l-3-[4'-( 1,1-dioxo-llambda*6*-thiomorpholinc-4-carbonyl)-3- lrinuoromcthyl-biphenyl-4-ylmelhyrj-pyrrolidin-2-onc; 3-| 4'-(4-lert-3utyl-pipcrazine-l-carbony l)-3-trifluoromclhyI-biphcny 1-4- ylmethyl |-1 -cyclohexyl-pyrrolidin-2-one; l-Cyciohexyl-3-[4'-(piperazine-l-carbonyl)-3-trifluoromethyl-biphcnyl-4- ylmethyl]-pyrrolidin-2-one; 1-Cyclohcxy 1-3-[4'-|4-(2-fluoro-cthyl)-pipcrazinc-l -carbony! |-3-lrif1uoromclhy I- biphcnyl-4-ylmethyl}-pyrrolidin-2-onc; 1-Cyclohcxy l-3-|3-trinuoromethyl-4'-(4-trifluoromclhyl-pipcridinc-l -carbonyl )- biphcnyl-4-ylmclhyr|-pyrro!idin-2-one; l-CycIohexyI-3-[4'-(4-methyl-piperazine-l-carbonyi)-3-trifluoromethyl-biphenyl-4-ylmethyl]-pyrrolidin-2-one; 3',5'-Dichloro-4'-[(R)-trans-l-(4-hydroxy-cyclohexyI)-2-oxo-pyrrolidin-3-yjmethyl]-biphenyl-4-carboxylic acid methylcarbamoylmethyl-amide; (R)-3-[3,5-Dichloro-4'-(4-methy]-piperidine-l-carbonyl)-biphenyl-4-ylmclhyl]-trans-1 -(4-hydroxy-cycIohexyl)-pyrrolidin-2-one; 3',5,-Dichloro-4'-[(R)-trans-l-(4-hydroxy-cycIohexyl)-2-oxo-pyrrolidinr3-ylmethyl]-biphenyl-4-carboxylic acid dimethylcarbamoyl methyl-amide; 3,,5'-Dichloro-4'-[(R)-trans-l-(4-hydroxy-cyclohexyl)-2-oxo-pyrrolidin-3-. ylmethyl]-biphenyl-4-carboxylic acid carbamoylmethyl-amide; (R)-3-[3i5-Dichloro-4,-(4-trifluoromethyl-piperidine-l-carbonyi)-biphenyI-4- ylmemyl]-trans-l-(4--memoxy-cyclohexyI)-pyrrolidin-2-\one; and (R)-3-[3,5-Dichloro-4'-(4)diflu6ro-piperidine-l-carbonyI)-biphenyI-4--ylmethyl]-trans-l-(4-methoxy-cyclohexyI)-pyrrolidin-2-one; ' or a pharmaceutical ly acceptable salt thereof. 17. A pharmaceutical composition which comprises a compound as claimed by any .. one .of Claims :through 16 or a pharmaceutically acceptable saltthereof and, a- pharmaceutically acceptable carrier. 18. A compound as claimed by any one of Claims 1 through 16, or a pharmaceutically acceptable salt thereof, for use in the preparation of a medicament. Dated this the 30th day of September, 2008. [Amrish Tiwari] Of K&S Partners Agent for the Applicant(s)

Documents:

2104-MUMNP-2008-ABSTRACT(2-9-2011).pdf

2104-MUMNP-2008-ABSTRACT(30-9-2008).pdf

2104-MUMNP-2008-ABSTRACT(GRANTED)-(21-3-2012).pdf

2104-mumnp-2008-abstract.doc

2104-mumnp-2008-abstract.pdf

2104-MUMNP-2008-ASSIGNMENT(17-2-2011).pdf

2104-MUMNP-2008-ASSIGNMENT(2-9-2011).pdf

2104-MUMNP-2008-CANCELLED PAGES(2-3-2012).pdf

2104-MUMNP-2008-CANCELLED PAGES(2-9-2011).pdf

2104-MUMNP-2008-CLAIMS(30-9-2008).pdf

2104-MUMNP-2008-CLAIMS(AMENDED)-(2-3-2012).pdf

2104-MUMNP-2008-CLAIMS(AMENDED)-(2-9-2011).pdf

2104-MUMNP-2008-CLAIMS(GRANTED)-(21-3-2012).pdf

2104-MUMNP-2008-CLAIMS(MARKED COPY)-(2-9-2011).pdf

2104-mumnp-2008-claims.doc

2104-mumnp-2008-claims.pdf

2104-MUMNP-2008-CORRESPONDENCE(15-12-2011).pdf

2104-MUMNP-2008-CORRESPONDENCE(17-11-2008).pdf

2104-MUMNP-2008-CORRESPONDENCE(17-2-2011).pdf

2104-MUMNP-2008-CORRESPONDENCE(2-3-2012).pdf

2104-MUMNP-2008-CORRESPONDENCE(22-12-2011).pdf

2104-MUMNP-2008-CORRESPONDENCE(8-4-2009).pdf

2104-MUMNP-2008-CORRESPONDENCE(IPO)-(21-3-2012).pdf

2104-mumnp-2008-correspondence.pdf

2104-MUMNP-2008-DESCRIPTION(COMPLETE)-(30-9-2008).pdf

2104-mumnp-2008-description(complete).doc

2104-mumnp-2008-description(complete).pdf

2104-MUMNP-2008-DESCRIPTION(GRANTED)-(21-3-2012).pdf

2104-MUMNP-2008-FORM 1(2-3-2012).pdf

2104-MUMNP-2008-FORM 1(2-9-2011).pdf

2104-mumnp-2008-form 1.pdf

2104-mumnp-2008-form 13(30-09-2008).pdf

2104-mumnp-2008-form 13.pdf

2104-mumnp-2008-form 18.pdf

2104-MUMNP-2008-FORM 2(COMPLETE)-(30-9-2008).pdf

2104-MUMNP-2008-FORM 2(GRANTED)-(21-3-2012).pdf

2104-MUMNP-2008-FORM 2(TITLE PAGE)-(2-9-2011).pdf

2104-MUMNP-2008-FORM 2(TITLE PAGE)-(30-9-2008).pdf

2104-MUMNP-2008-FORM 2(TITLE PAGE)-(GRANTED)-(21-3-2012).pdf

2104-mumnp-2008-form 2(title page).pdf

2104-mumnp-2008-form 2.doc

2104-mumnp-2008-form 2.pdf

2104-MUMNP-2008-FORM 26(2-9-2011).pdf

2104-MUMNP-2008-FORM 3(15-12-2011).pdf

2104-MUMNP-2008-FORM 3(2-9-2011).pdf

2104-MUMNP-2008-FORM 3(22-12-2011).pdf

2104-mumnp-2008-form 3(30-9-2008).pdf

2104-MUMNP-2008-FORM 3(8-4-2009).pdf

2104-mumnp-2008-form 3.pdf

2104-mumnp-2008-form 5.pdf

2104-mumnp-2008-international publication report a1.pdf

2104-MUMNP-2008-OTHER DOCUMENT(2-9-2011).pdf

2104-mumnp-2008-pct request.pdf

2104-mumnp-2008-pct-ib-304.pdf

2104-mumnp-2008-pct-ib-311.pdf

2104-mumnp-2008-pct-isa-210.pdf

2104-mumnp-2008-pct-isa-220.pdf

2104-MUMNP-2008-PCT-ISA-237(17-11-2008).pdf

2104-mumnp-2008-pct-isa-237.pdf

2104-MUMNP-2008-PETITION UNDER RULE 137(2-9-2011).pdf

2104-MUMNP-2008-PETITION UNDER RULE 137(22-12-2011).pdf

2104-MUMNP-2008-PETITION UNDER RULE-137(2-3-2012).pdf

2104-MUMNP-2008-REPLY TO EXAMINATION REPORT(2-9-2011).pdf

2104-MUMNP-2008-US DOCUMENT(15-12-2011).pdf

2104-MUMNP-2008-WO INTERNATIONAL PUBLICATION REPORT(30-9-2008).pdf

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